-- dump date 20140619_041823 -- class Genbank::misc_feature -- table misc_feature_note -- id note 251229000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 251229000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 251229000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229000004 Walker A motif; other site 251229000005 ATP binding site [chemical binding]; other site 251229000006 Walker B motif; other site 251229000007 arginine finger; other site 251229000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 251229000009 DnaA box-binding interface [nucleotide binding]; other site 251229000010 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 251229000011 ABC1 family; Region: ABC1; cl17513 251229000012 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 251229000013 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 251229000014 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 251229000015 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 251229000016 active site 251229000017 intersubunit interface [polypeptide binding]; other site 251229000018 catalytic residue [active] 251229000019 PRC-barrel domain; Region: PRC; pfam05239 251229000020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 251229000021 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 251229000022 ATP-sulfurylase; Region: ATPS; cd00517 251229000023 active site 251229000024 HXXH motif; other site 251229000025 flexible loop; other site 251229000026 Caspase domain; Region: Peptidase_C14; pfam00656 251229000027 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 251229000028 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 251229000029 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 251229000030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229000031 S-adenosylmethionine binding site [chemical binding]; other site 251229000032 Tetratricopeptide repeat; Region: TPR_16; pfam13432 251229000033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229000034 binding surface 251229000035 Tetratricopeptide repeat; Region: TPR_16; pfam13432 251229000036 TPR motif; other site 251229000037 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251229000038 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 251229000039 Response regulator receiver domain; Region: Response_reg; pfam00072 251229000040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229000041 active site 251229000042 phosphorylation site [posttranslational modification] 251229000043 intermolecular recognition site; other site 251229000044 dimerization interface [polypeptide binding]; other site 251229000045 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 251229000046 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 251229000047 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 251229000048 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 251229000049 putative binding surface; other site 251229000050 active site 251229000051 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 251229000052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229000053 ATP binding site [chemical binding]; other site 251229000054 Mg2+ binding site [ion binding]; other site 251229000055 G-X-G motif; other site 251229000056 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 251229000057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229000058 Response regulator receiver domain; Region: Response_reg; pfam00072 251229000059 active site 251229000060 phosphorylation site [posttranslational modification] 251229000061 intermolecular recognition site; other site 251229000062 dimerization interface [polypeptide binding]; other site 251229000063 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 251229000064 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 251229000065 dimer interface [polypeptide binding]; other site 251229000066 putative CheW interface [polypeptide binding]; other site 251229000067 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229000068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229000069 active site 251229000070 phosphorylation site [posttranslational modification] 251229000071 intermolecular recognition site; other site 251229000072 dimerization interface [polypeptide binding]; other site 251229000073 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 251229000074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229000075 active site 251229000076 phosphorylation site [posttranslational modification] 251229000077 intermolecular recognition site; other site 251229000078 dimerization interface [polypeptide binding]; other site 251229000079 CheB methylesterase; Region: CheB_methylest; pfam01339 251229000080 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 251229000081 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 251229000082 PAS fold; Region: PAS_4; pfam08448 251229000083 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 251229000084 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 251229000085 OstA-like protein; Region: OstA; cl00844 251229000086 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 251229000087 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 251229000088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229000089 Walker A/P-loop; other site 251229000090 ATP binding site [chemical binding]; other site 251229000091 Q-loop/lid; other site 251229000092 ABC transporter signature motif; other site 251229000093 Walker B; other site 251229000094 D-loop; other site 251229000095 H-loop/switch region; other site 251229000096 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 251229000097 DNA protecting protein DprA; Region: dprA; TIGR00732 251229000098 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 251229000099 classical (c) SDRs; Region: SDR_c; cd05233 251229000100 NAD(P) binding site [chemical binding]; other site 251229000101 active site 251229000102 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 251229000103 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 251229000104 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 251229000105 motif 1; other site 251229000106 active site 251229000107 motif 2; other site 251229000108 motif 3; other site 251229000109 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 251229000110 FeoC like transcriptional regulator; Region: FeoC; pfam09012 251229000111 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 251229000112 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 251229000113 G1 box; other site 251229000114 GTP/Mg2+ binding site [chemical binding]; other site 251229000115 Switch I region; other site 251229000116 G2 box; other site 251229000117 G3 box; other site 251229000118 Switch II region; other site 251229000119 G4 box; other site 251229000120 G5 box; other site 251229000121 Nucleoside recognition; Region: Gate; pfam07670 251229000122 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 251229000123 Nucleoside recognition; Region: Gate; pfam07670 251229000124 FeoA domain; Region: FeoA; pfam04023 251229000125 FeoA domain; Region: FeoA; pfam04023 251229000126 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 251229000127 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 251229000128 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 251229000129 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 251229000130 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 251229000131 active site 251229000132 catalytic residues [active] 251229000133 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229000134 putative active site [active] 251229000135 NAD synthetase; Provisional; Region: PRK13981 251229000136 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 251229000137 multimer interface [polypeptide binding]; other site 251229000138 active site 251229000139 catalytic triad [active] 251229000140 protein interface 1 [polypeptide binding]; other site 251229000141 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 251229000142 homodimer interface [polypeptide binding]; other site 251229000143 NAD binding pocket [chemical binding]; other site 251229000144 ATP binding pocket [chemical binding]; other site 251229000145 Mg binding site [ion binding]; other site 251229000146 active-site loop [active] 251229000147 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 251229000148 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 251229000149 active site 251229000150 substrate binding site [chemical binding]; other site 251229000151 FMN binding site [chemical binding]; other site 251229000152 putative catalytic residues [active] 251229000153 Chorismate mutase type II; Region: CM_2; cl00693 251229000154 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 251229000155 nudix motif; other site 251229000156 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 251229000157 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 251229000158 active site 251229000159 (T/H)XGH motif; other site 251229000160 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 251229000161 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 251229000162 active site 251229000163 hypothetical protein; Reviewed; Region: PRK00024 251229000164 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 251229000165 MPN+ (JAMM) motif; other site 251229000166 Zinc-binding site [ion binding]; other site 251229000167 phosphoribulokinase; Provisional; Region: PRK07429 251229000168 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 251229000169 active site 251229000170 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 251229000171 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 251229000172 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 251229000173 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 251229000174 ERF superfamily; Region: ERF; pfam04404 251229000175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229000176 Coenzyme A binding pocket [chemical binding]; other site 251229000177 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 251229000178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229000179 motif II; other site 251229000180 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 251229000181 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 251229000182 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 251229000183 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 251229000184 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 251229000185 ATP-grasp ribosomal peptide maturase, MvdD family; Region: ATPgraspMvdD; TIGR04184 251229000186 ATP-grasp domain; Region: ATP-grasp_4; cl17255 251229000187 Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559 251229000188 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 251229000189 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 251229000190 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 251229000191 putative active site [active] 251229000192 catalytic site [active] 251229000193 NifU-like domain; Region: NifU; pfam01106 251229000194 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 251229000195 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229000196 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229000197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229000198 dimer interface [polypeptide binding]; other site 251229000199 phosphorylation site [posttranslational modification] 251229000200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229000201 ATP binding site [chemical binding]; other site 251229000202 Mg2+ binding site [ion binding]; other site 251229000203 G-X-G motif; other site 251229000204 GTP-binding protein LepA; Provisional; Region: PRK05433 251229000205 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 251229000206 G1 box; other site 251229000207 putative GEF interaction site [polypeptide binding]; other site 251229000208 GTP/Mg2+ binding site [chemical binding]; other site 251229000209 Switch I region; other site 251229000210 G2 box; other site 251229000211 G3 box; other site 251229000212 Switch II region; other site 251229000213 G4 box; other site 251229000214 G5 box; other site 251229000215 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 251229000216 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 251229000217 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 251229000218 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 251229000219 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 251229000220 Ligand Binding Site [chemical binding]; other site 251229000221 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 251229000222 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 251229000223 G1 box; other site 251229000224 putative GEF interaction site [polypeptide binding]; other site 251229000225 GTP/Mg2+ binding site [chemical binding]; other site 251229000226 Switch I region; other site 251229000227 G2 box; other site 251229000228 G3 box; other site 251229000229 Switch II region; other site 251229000230 G4 box; other site 251229000231 G5 box; other site 251229000232 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 251229000233 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 251229000234 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 251229000235 non-specific DNA binding site [nucleotide binding]; other site 251229000236 salt bridge; other site 251229000237 sequence-specific DNA binding site [nucleotide binding]; other site 251229000238 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 251229000239 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 251229000240 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 251229000241 HD domain; Region: HD_4; pfam13328 251229000242 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 251229000243 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 251229000244 Walker A/P-loop; other site 251229000245 ATP binding site [chemical binding]; other site 251229000246 Q-loop/lid; other site 251229000247 ABC transporter signature motif; other site 251229000248 Walker B; other site 251229000249 D-loop; other site 251229000250 H-loop/switch region; other site 251229000251 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251229000252 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229000253 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 251229000254 Walker A/P-loop; other site 251229000255 ATP binding site [chemical binding]; other site 251229000256 Q-loop/lid; other site 251229000257 ABC transporter signature motif; other site 251229000258 Walker B; other site 251229000259 D-loop; other site 251229000260 H-loop/switch region; other site 251229000261 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 251229000262 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 251229000263 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 251229000264 acyl-activating enzyme (AAE) consensus motif; other site 251229000265 AMP binding site [chemical binding]; other site 251229000266 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229000267 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 251229000268 EamA-like transporter family; Region: EamA; pfam00892 251229000269 EamA-like transporter family; Region: EamA; pfam00892 251229000270 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 251229000271 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 251229000272 protein binding site [polypeptide binding]; other site 251229000273 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 251229000274 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 251229000275 protein binding site [polypeptide binding]; other site 251229000276 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251229000277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 251229000278 active site 251229000279 phosphorylation site [posttranslational modification] 251229000280 intermolecular recognition site; other site 251229000281 dimerization interface [polypeptide binding]; other site 251229000282 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251229000283 DNA binding residues [nucleotide binding] 251229000284 dimerization interface [polypeptide binding]; other site 251229000285 CP12 domain; Region: CP12; pfam02672 251229000286 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 251229000287 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229000288 Coenzyme A binding pocket [chemical binding]; other site 251229000289 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251229000290 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 251229000291 active site 251229000292 catalytic tetrad [active] 251229000293 Protein of unknown function DUF91; Region: DUF91; cl00709 251229000294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229000295 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 251229000296 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 251229000297 P loop; other site 251229000298 Nucleotide binding site [chemical binding]; other site 251229000299 DTAP/Switch II; other site 251229000300 Switch I; other site 251229000301 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 251229000302 DNA polymerase III subunit beta; Validated; Region: PRK05643 251229000303 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 251229000304 putative DNA binding surface [nucleotide binding]; other site 251229000305 dimer interface [polypeptide binding]; other site 251229000306 beta-clamp/clamp loader binding surface; other site 251229000307 beta-clamp/translesion DNA polymerase binding surface; other site 251229000308 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 251229000309 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 251229000310 homodimer interface [polypeptide binding]; other site 251229000311 substrate-cofactor binding pocket; other site 251229000312 catalytic residue [active] 251229000313 FAD dependent oxidoreductase; Region: DAO; pfam01266 251229000314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229000315 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 251229000316 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 251229000317 trimer interface [polypeptide binding]; other site 251229000318 active site 251229000319 substrate binding site [chemical binding]; other site 251229000320 CoA binding site [chemical binding]; other site 251229000321 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229000322 GAF domain; Region: GAF; pfam01590 251229000323 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251229000324 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 251229000325 putative NAD(P) binding site [chemical binding]; other site 251229000326 active site 251229000327 putative substrate binding site [chemical binding]; other site 251229000328 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229000329 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229000330 dimerization interface [polypeptide binding]; other site 251229000331 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229000332 dimer interface [polypeptide binding]; other site 251229000333 phosphorylation site [posttranslational modification] 251229000334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229000335 ATP binding site [chemical binding]; other site 251229000336 Mg2+ binding site [ion binding]; other site 251229000337 G-X-G motif; other site 251229000338 Response regulator receiver domain; Region: Response_reg; pfam00072 251229000339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229000340 active site 251229000341 phosphorylation site [posttranslational modification] 251229000342 intermolecular recognition site; other site 251229000343 dimerization interface [polypeptide binding]; other site 251229000344 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 251229000345 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229000346 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229000347 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 251229000348 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 251229000349 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251229000350 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229000351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229000352 Walker A/P-loop; other site 251229000353 ATP binding site [chemical binding]; other site 251229000354 Q-loop/lid; other site 251229000355 ABC transporter signature motif; other site 251229000356 Walker B; other site 251229000357 D-loop; other site 251229000358 H-loop/switch region; other site 251229000359 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 251229000360 catalytic core [active] 251229000361 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 251229000362 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 251229000363 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 251229000364 putative ADP-binding pocket [chemical binding]; other site 251229000365 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 251229000366 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 251229000367 putative ADP-binding pocket [chemical binding]; other site 251229000368 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 251229000369 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 251229000370 active site 251229000371 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229000372 Protein of unknown function (DUF938); Region: DUF938; pfam06080 251229000373 D-xylulose kinase; Region: XylB; TIGR01312 251229000374 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 251229000375 nucleotide binding site [chemical binding]; other site 251229000376 Photosystem I protein M (PsaM); Region: PsaM; cl15374 251229000377 TPR repeat; Region: TPR_11; pfam13414 251229000378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229000379 binding surface 251229000380 TPR motif; other site 251229000381 TPR repeat; Region: TPR_11; pfam13414 251229000382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 251229000383 TPR repeat; Region: TPR_11; pfam13414 251229000384 binding surface 251229000385 TPR motif; other site 251229000386 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 251229000387 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 251229000388 putative C-terminal domain interface [polypeptide binding]; other site 251229000389 putative GSH binding site (G-site) [chemical binding]; other site 251229000390 putative dimer interface [polypeptide binding]; other site 251229000391 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 251229000392 N-terminal domain interface [polypeptide binding]; other site 251229000393 dimer interface [polypeptide binding]; other site 251229000394 substrate binding pocket (H-site) [chemical binding]; other site 251229000395 Photosystem II 4 kDa reaction centre component; Region: PsbK; pfam02533 251229000396 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 251229000397 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 251229000398 putative di-iron ligands [ion binding]; other site 251229000399 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 251229000400 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229000401 Coenzyme A binding pocket [chemical binding]; other site 251229000402 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 251229000403 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 251229000404 Walker A/P-loop; other site 251229000405 ATP binding site [chemical binding]; other site 251229000406 Q-loop/lid; other site 251229000407 ABC transporter signature motif; other site 251229000408 Walker B; other site 251229000409 D-loop; other site 251229000410 H-loop/switch region; other site 251229000411 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 251229000412 Walker A/P-loop; other site 251229000413 ATP binding site [chemical binding]; other site 251229000414 Q-loop/lid; other site 251229000415 ABC transporter signature motif; other site 251229000416 Walker B; other site 251229000417 D-loop; other site 251229000418 H-loop/switch region; other site 251229000419 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 251229000420 Predicted dehydrogenase [General function prediction only]; Region: COG0579 251229000421 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 251229000422 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 251229000423 putative binding surface; other site 251229000424 active site 251229000425 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 251229000426 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 251229000427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229000428 ATP binding site [chemical binding]; other site 251229000429 Mg2+ binding site [ion binding]; other site 251229000430 G-X-G motif; other site 251229000431 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 251229000432 Response regulator receiver domain; Region: Response_reg; pfam00072 251229000433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229000434 active site 251229000435 phosphorylation site [posttranslational modification] 251229000436 intermolecular recognition site; other site 251229000437 dimerization interface [polypeptide binding]; other site 251229000438 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229000439 TPR motif; other site 251229000440 binding surface 251229000441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229000442 dimerization interface [polypeptide binding]; other site 251229000443 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 251229000444 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 251229000445 dimer interface [polypeptide binding]; other site 251229000446 putative CheW interface [polypeptide binding]; other site 251229000447 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 251229000448 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229000449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229000450 active site 251229000451 phosphorylation site [posttranslational modification] 251229000452 intermolecular recognition site; other site 251229000453 dimerization interface [polypeptide binding]; other site 251229000454 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 251229000455 Response regulator receiver domain; Region: Response_reg; pfam00072 251229000456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229000457 active site 251229000458 phosphorylation site [posttranslational modification] 251229000459 intermolecular recognition site; other site 251229000460 dimerization interface [polypeptide binding]; other site 251229000461 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 251229000462 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 251229000463 Ligand Binding Site [chemical binding]; other site 251229000464 cytochrome c biogenesis protein; Region: ccsA; CHL00045 251229000465 cytochrome c biogenesis protein; Region: ccsA; CHL00045 251229000466 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 251229000467 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 251229000468 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 251229000469 Walker A/P-loop; other site 251229000470 ATP binding site [chemical binding]; other site 251229000471 Q-loop/lid; other site 251229000472 ABC transporter signature motif; other site 251229000473 Walker B; other site 251229000474 D-loop; other site 251229000475 H-loop/switch region; other site 251229000476 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 251229000477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229000478 dimer interface [polypeptide binding]; other site 251229000479 conserved gate region; other site 251229000480 putative PBP binding loops; other site 251229000481 ABC-ATPase subunit interface; other site 251229000482 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 251229000483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229000484 dimer interface [polypeptide binding]; other site 251229000485 conserved gate region; other site 251229000486 putative PBP binding loops; other site 251229000487 ABC-ATPase subunit interface; other site 251229000488 phosphate binding protein; Region: ptsS_2; TIGR02136 251229000489 BioY family; Region: BioY; pfam02632 251229000490 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 251229000491 lipoprotein signal peptidase; Provisional; Region: PRK14787 251229000492 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251229000493 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 251229000494 phosphopeptide binding site; other site 251229000495 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 251229000496 Transglycosylase; Region: Transgly; pfam00912 251229000497 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 251229000498 Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935 251229000499 TIGR02588 family protein; Region: TIGR02588 251229000500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229000501 TPR motif; other site 251229000502 TPR repeat; Region: TPR_11; pfam13414 251229000503 binding surface 251229000504 TPR repeat; Region: TPR_11; pfam13414 251229000505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229000506 binding surface 251229000507 TPR motif; other site 251229000508 TPR repeat; Region: TPR_11; pfam13414 251229000509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229000510 binding surface 251229000511 TPR motif; other site 251229000512 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251229000513 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 251229000514 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229000515 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251229000516 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 251229000517 FtsX-like permease family; Region: FtsX; pfam02687 251229000518 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251229000519 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 251229000520 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229000521 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251229000522 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 251229000523 FtsX-like permease family; Region: FtsX; pfam02687 251229000524 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 251229000525 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 251229000526 Walker A/P-loop; other site 251229000527 ATP binding site [chemical binding]; other site 251229000528 Q-loop/lid; other site 251229000529 ABC transporter signature motif; other site 251229000530 Walker B; other site 251229000531 D-loop; other site 251229000532 H-loop/switch region; other site 251229000533 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 251229000534 H+ Antiporter protein; Region: 2A0121; TIGR00900 251229000535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229000536 putative substrate translocation pore; other site 251229000537 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 251229000538 MarR family; Region: MarR_2; cl17246 251229000539 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 251229000540 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229000541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229000542 S-adenosylmethionine binding site [chemical binding]; other site 251229000543 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229000544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229000545 S-adenosylmethionine binding site [chemical binding]; other site 251229000546 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 251229000547 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 251229000548 putative ADP-binding pocket [chemical binding]; other site 251229000549 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 251229000550 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 251229000551 Ligand binding site; other site 251229000552 Putative Catalytic site; other site 251229000553 DXD motif; other site 251229000554 Predicted membrane protein [Function unknown]; Region: COG2246 251229000555 GtrA-like protein; Region: GtrA; pfam04138 251229000556 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 251229000557 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 251229000558 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 251229000559 catalytic residue [active] 251229000560 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 251229000561 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 251229000562 cofactor binding site; other site 251229000563 DNA binding site [nucleotide binding] 251229000564 substrate interaction site [chemical binding]; other site 251229000565 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 251229000566 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 251229000567 intersubunit interface [polypeptide binding]; other site 251229000568 active site 251229000569 catalytic residue [active] 251229000570 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 251229000571 Recombination protein O N terminal; Region: RecO_N; pfam11967 251229000572 Recombination protein O C terminal; Region: RecO_C; pfam02565 251229000573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229000574 H+ Antiporter protein; Region: 2A0121; TIGR00900 251229000575 putative substrate translocation pore; other site 251229000576 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229000577 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229000578 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 251229000579 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 251229000580 phosphoglyceromutase; Provisional; Region: PRK05434 251229000581 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 251229000582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229000583 Walker A/P-loop; other site 251229000584 ATP binding site [chemical binding]; other site 251229000585 Q-loop/lid; other site 251229000586 ABC transporter signature motif; other site 251229000587 Walker B; other site 251229000588 D-loop; other site 251229000589 H-loop/switch region; other site 251229000590 ABC transporter; Region: ABC_tran_2; pfam12848 251229000591 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 251229000592 putrescine aminotransferase; Region: putres_am_tran; TIGR03372 251229000593 peptide chain release factor 1; Validated; Region: prfA; PRK00591 251229000594 This domain is found in peptide chain release factors; Region: PCRF; smart00937 251229000595 RF-1 domain; Region: RF-1; pfam00472 251229000596 ribosomal protein L31; Validated; Region: rpl31; CHL00136 251229000597 ribosomal protein S9; Region: rps9; CHL00079 251229000598 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 251229000599 23S rRNA interface [nucleotide binding]; other site 251229000600 L3 interface [polypeptide binding]; other site 251229000601 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 251229000602 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 251229000603 dimerization interface 3.5A [polypeptide binding]; other site 251229000604 active site 251229000605 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 251229000606 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 251229000607 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 251229000608 alphaNTD homodimer interface [polypeptide binding]; other site 251229000609 alphaNTD - beta interaction site [polypeptide binding]; other site 251229000610 alphaNTD - beta' interaction site [polypeptide binding]; other site 251229000611 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 251229000612 30S ribosomal protein S11; Validated; Region: PRK05309 251229000613 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 251229000614 30S ribosomal protein S13; Region: bact_S13; TIGR03631 251229000615 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 251229000616 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 251229000617 rRNA binding site [nucleotide binding]; other site 251229000618 predicted 30S ribosome binding site; other site 251229000619 adenylate kinase; Provisional; Region: adk; PRK02496 251229000620 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 251229000621 AMP-binding site [chemical binding]; other site 251229000622 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 251229000623 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 251229000624 SecY translocase; Region: SecY; pfam00344 251229000625 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 251229000626 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 251229000627 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 251229000628 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 251229000629 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 251229000630 23S rRNA interface [nucleotide binding]; other site 251229000631 L21e interface [polypeptide binding]; other site 251229000632 5S rRNA interface [nucleotide binding]; other site 251229000633 L27 interface [polypeptide binding]; other site 251229000634 L5 interface [polypeptide binding]; other site 251229000635 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 251229000636 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 251229000637 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 251229000638 ribosomal protein S8; Region: rps8; CHL00042 251229000639 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 251229000640 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 251229000641 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 251229000642 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 251229000643 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 251229000644 RNA binding site [nucleotide binding]; other site 251229000645 ribosomal protein L14; Region: rpl14; CHL00057 251229000646 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 251229000647 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 251229000648 23S rRNA interface [nucleotide binding]; other site 251229000649 putative translocon interaction site; other site 251229000650 signal recognition particle (SRP54) interaction site; other site 251229000651 L23 interface [polypeptide binding]; other site 251229000652 trigger factor interaction site; other site 251229000653 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 251229000654 23S rRNA interface [nucleotide binding]; other site 251229000655 5S rRNA interface [nucleotide binding]; other site 251229000656 putative antibiotic binding site [chemical binding]; other site 251229000657 L25 interface [polypeptide binding]; other site 251229000658 L27 interface [polypeptide binding]; other site 251229000659 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 251229000660 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 251229000661 G-X-X-G motif; other site 251229000662 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 251229000663 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 251229000664 putative translocon binding site; other site 251229000665 protein-rRNA interface [nucleotide binding]; other site 251229000666 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 251229000667 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 251229000668 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 251229000669 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 251229000670 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 251229000671 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 251229000672 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 251229000673 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 251229000674 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 251229000675 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 251229000676 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 251229000677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229000678 Walker A motif; other site 251229000679 ATP binding site [chemical binding]; other site 251229000680 Walker B motif; other site 251229000681 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 251229000682 RxxxH motif; other site 251229000683 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 251229000684 conserved cys residue [active] 251229000685 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 251229000686 NurA nuclease; Region: NurA; smart00933 251229000687 short chain dehydrogenase; Provisional; Region: PRK07454 251229000688 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 251229000689 NADP binding site [chemical binding]; other site 251229000690 substrate binding site [chemical binding]; other site 251229000691 active site 251229000692 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 251229000693 Helix-turn-helix domain; Region: HTH_25; pfam13413 251229000694 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 251229000695 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 251229000696 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 251229000697 RNA binding surface [nucleotide binding]; other site 251229000698 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 251229000699 active site 251229000700 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 251229000701 phosphatidate cytidylyltransferase; Region: PLN02953 251229000702 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 251229000703 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 251229000704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229000705 S-adenosylmethionine binding site [chemical binding]; other site 251229000706 Ion channel; Region: Ion_trans_2; pfam07885 251229000707 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 251229000708 TrkA-N domain; Region: TrkA_N; pfam02254 251229000709 TrkA-C domain; Region: TrkA_C; pfam02080 251229000710 acetylornithine aminotransferase; Provisional; Region: PRK02627 251229000711 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 251229000712 inhibitor-cofactor binding pocket; inhibition site 251229000713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229000714 catalytic residue [active] 251229000715 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 251229000716 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 251229000717 active site 251229000718 Zn binding site [ion binding]; other site 251229000719 CheW-like domain; Region: CheW; pfam01584 251229000720 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 251229000721 putative binding surface; other site 251229000722 active site 251229000723 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 251229000724 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 251229000725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229000726 ATP binding site [chemical binding]; other site 251229000727 Mg2+ binding site [ion binding]; other site 251229000728 G-X-G motif; other site 251229000729 Two component signalling adaptor domain; Region: CheW; smart00260 251229000730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229000731 Response regulator receiver domain; Region: Response_reg; pfam00072 251229000732 active site 251229000733 phosphorylation site [posttranslational modification] 251229000734 intermolecular recognition site; other site 251229000735 dimerization interface [polypeptide binding]; other site 251229000736 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229000737 dimerization interface [polypeptide binding]; other site 251229000738 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229000739 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229000740 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229000741 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229000742 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 251229000743 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 251229000744 dimer interface [polypeptide binding]; other site 251229000745 putative CheW interface [polypeptide binding]; other site 251229000746 Cache domain; Region: Cache_1; pfam02743 251229000747 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229000748 dimerization interface [polypeptide binding]; other site 251229000749 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229000750 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229000751 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229000752 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229000753 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 251229000754 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 251229000755 dimer interface [polypeptide binding]; other site 251229000756 putative CheW interface [polypeptide binding]; other site 251229000757 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 251229000758 Response regulator receiver domain; Region: Response_reg; pfam00072 251229000759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229000760 active site 251229000761 phosphorylation site [posttranslational modification] 251229000762 intermolecular recognition site; other site 251229000763 dimerization interface [polypeptide binding]; other site 251229000764 Response regulator receiver domain; Region: Response_reg; pfam00072 251229000765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229000766 active site 251229000767 phosphorylation site [posttranslational modification] 251229000768 intermolecular recognition site; other site 251229000769 dimerization interface [polypeptide binding]; other site 251229000770 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 251229000771 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 251229000772 substrate binding site; other site 251229000773 Predicted dehydrogenase [General function prediction only]; Region: COG0579 251229000774 hydroxyglutarate oxidase; Provisional; Region: PRK11728 251229000775 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 251229000776 extended (e) SDRs; Region: SDR_e; cd08946 251229000777 NAD(P) binding site [chemical binding]; other site 251229000778 active site 251229000779 substrate binding site [chemical binding]; other site 251229000780 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 251229000781 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229000782 Methyltransferase domain; Region: Methyltransf_12; pfam08242 251229000783 S-adenosylmethionine binding site [chemical binding]; other site 251229000784 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 251229000785 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 251229000786 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229000787 active site 251229000788 M28 Zn-Peptidases; Region: M28_like_3; cd05644 251229000789 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 251229000790 active site 251229000791 metal binding site [ion binding]; metal-binding site 251229000792 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251229000793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229000794 NAD(P) binding site [chemical binding]; other site 251229000795 active site 251229000796 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 251229000797 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229000798 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229000799 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229000800 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229000801 Bacterial sugar transferase; Region: Bac_transf; cl00939 251229000802 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 251229000803 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 251229000804 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 251229000805 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 251229000806 active site 251229000807 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 251229000808 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 251229000809 DXD motif; other site 251229000810 O-Antigen ligase; Region: Wzy_C; pfam04932 251229000811 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229000812 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 251229000813 putative ADP-binding pocket [chemical binding]; other site 251229000814 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 251229000815 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 251229000816 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 251229000817 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 251229000818 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 251229000819 YcfA-like protein; Region: YcfA; pfam07927 251229000820 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 251229000821 ribonuclease PH; Reviewed; Region: rph; PRK00173 251229000822 Ribonuclease PH; Region: RNase_PH_bact; cd11362 251229000823 hexamer interface [polypeptide binding]; other site 251229000824 active site 251229000825 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 251229000826 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 251229000827 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 251229000828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229000829 S-adenosylmethionine binding site [chemical binding]; other site 251229000830 PAS domain; Region: PAS_10; pfam13596 251229000831 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 251229000832 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 251229000833 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 251229000834 RNA polymerase sigma factor SigC; Validated; Region: PRK07598 251229000835 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 251229000836 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251229000837 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 251229000838 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251229000839 DNA binding residues [nucleotide binding] 251229000840 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 251229000841 metal binding site 2 [ion binding]; metal-binding site 251229000842 putative DNA binding helix; other site 251229000843 metal binding site 1 [ion binding]; metal-binding site 251229000844 dimer interface [polypeptide binding]; other site 251229000845 structural Zn2+ binding site [ion binding]; other site 251229000846 Ycf46; Provisional; Region: ycf46; CHL00195 251229000847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229000848 Walker A motif; other site 251229000849 ATP binding site [chemical binding]; other site 251229000850 Walker B motif; other site 251229000851 arginine finger; other site 251229000852 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 251229000853 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 251229000854 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 251229000855 G-X-X-G motif; other site 251229000856 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 251229000857 RxxxH motif; other site 251229000858 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 251229000859 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 251229000860 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 251229000861 Bacterial PH domain; Region: DUF304; pfam03703 251229000862 ribonuclease P; Reviewed; Region: rnpA; PRK03031 251229000863 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 251229000864 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 251229000865 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 251229000866 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 251229000867 ligand binding site [chemical binding]; other site 251229000868 homodimer interface [polypeptide binding]; other site 251229000869 NAD(P) binding site [chemical binding]; other site 251229000870 trimer interface B [polypeptide binding]; other site 251229000871 trimer interface A [polypeptide binding]; other site 251229000872 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 251229000873 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 251229000874 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 251229000875 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 251229000876 dimer interface [polypeptide binding]; other site 251229000877 [2Fe-2S] cluster binding site [ion binding]; other site 251229000878 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 251229000879 active site 251229000880 ATP binding site [chemical binding]; other site 251229000881 substrate binding site [chemical binding]; other site 251229000882 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 251229000883 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 251229000884 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229000885 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229000886 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229000887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229000888 dimer interface [polypeptide binding]; other site 251229000889 phosphorylation site [posttranslational modification] 251229000890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229000891 ATP binding site [chemical binding]; other site 251229000892 Mg2+ binding site [ion binding]; other site 251229000893 G-X-G motif; other site 251229000894 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 251229000895 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 251229000896 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 251229000897 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 251229000898 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 251229000899 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251229000900 active site 251229000901 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 251229000902 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229000903 Walker A/P-loop; other site 251229000904 ATP binding site [chemical binding]; other site 251229000905 Q-loop/lid; other site 251229000906 ABC transporter signature motif; other site 251229000907 Walker B; other site 251229000908 D-loop; other site 251229000909 H-loop/switch region; other site 251229000910 TOBE domain; Region: TOBE_2; pfam08402 251229000911 DNA gyrase subunit A; Validated; Region: PRK05560 251229000912 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 251229000913 CAP-like domain; other site 251229000914 active site 251229000915 primary dimer interface [polypeptide binding]; other site 251229000916 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 251229000917 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 251229000918 Response regulator receiver domain; Region: Response_reg; pfam00072 251229000919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229000920 active site 251229000921 phosphorylation site [posttranslational modification] 251229000922 intermolecular recognition site; other site 251229000923 dimerization interface [polypeptide binding]; other site 251229000924 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 251229000925 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 251229000926 inhibitor-cofactor binding pocket; inhibition site 251229000927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229000928 catalytic residue [active] 251229000929 ChaB; Region: ChaB; cl01887 251229000930 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 251229000931 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 251229000932 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 251229000933 metal binding site [ion binding]; metal-binding site 251229000934 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 251229000935 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 251229000936 catalytic triad [active] 251229000937 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 251229000938 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 251229000939 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 251229000940 putative dimer interface [polypeptide binding]; other site 251229000941 putative anticodon binding site; other site 251229000942 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 251229000943 homodimer interface [polypeptide binding]; other site 251229000944 motif 1; other site 251229000945 motif 2; other site 251229000946 active site 251229000947 motif 3; other site 251229000948 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 251229000949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 251229000950 Mg2+ binding site [ion binding]; other site 251229000951 G-X-G motif; other site 251229000952 TRAM domain; Region: TRAM; pfam01938 251229000953 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 251229000954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229000955 S-adenosylmethionine binding site [chemical binding]; other site 251229000956 Phycobilisome protein; Region: Phycobilisome; cl08227 251229000957 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 251229000958 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 251229000959 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 251229000960 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251229000961 active site 251229000962 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 251229000963 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 251229000964 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251229000965 FeS/SAM binding site; other site 251229000966 TRAM domain; Region: TRAM; pfam01938 251229000967 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 251229000968 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 251229000969 active site 251229000970 metal binding site [ion binding]; metal-binding site 251229000971 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229000972 short chain dehydrogenase; Provisional; Region: PRK06180 251229000973 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 251229000974 NADP binding site [chemical binding]; other site 251229000975 active site 251229000976 steroid binding site; other site 251229000977 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 251229000978 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 251229000979 putative NAD(P) binding site [chemical binding]; other site 251229000980 tellurium resistance terB-like protein; Region: terB_like; cd07177 251229000981 metal binding site [ion binding]; metal-binding site 251229000982 tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887 251229000983 UbiA prenyltransferase family; Region: UbiA; pfam01040 251229000984 tocopherol O-methyltransferase; Region: PLN02244 251229000985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229000986 S-adenosylmethionine binding site [chemical binding]; other site 251229000987 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 251229000988 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 251229000989 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 251229000990 TrkA-N domain; Region: TrkA_N; pfam02254 251229000991 TrkA-C domain; Region: TrkA_C; pfam02080 251229000992 lipoyl synthase; Provisional; Region: PRK05481 251229000993 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; pfam05430 251229000994 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 251229000995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229000996 Mg2+ binding site [ion binding]; other site 251229000997 G-X-G motif; other site 251229000998 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 251229000999 anchoring element; other site 251229001000 dimer interface [polypeptide binding]; other site 251229001001 ATP binding site [chemical binding]; other site 251229001002 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 251229001003 active site 251229001004 putative metal-binding site [ion binding]; other site 251229001005 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 251229001006 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 251229001007 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 251229001008 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 251229001009 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 251229001010 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 251229001011 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 251229001012 active site 251229001013 Ion channel; Region: Ion_trans_2; pfam07885 251229001014 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 251229001015 active site 251229001016 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 251229001017 active site 251229001018 Creatinine amidohydrolase; Region: Creatininase; pfam02633 251229001019 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 251229001020 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 251229001021 nucleotide binding site [chemical binding]; other site 251229001022 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 251229001023 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 251229001024 dimer interface [polypeptide binding]; other site 251229001025 motif 1; other site 251229001026 active site 251229001027 motif 2; other site 251229001028 motif 3; other site 251229001029 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 251229001030 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 251229001031 HSP70 interaction site [polypeptide binding]; other site 251229001032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229001033 binding surface 251229001034 TPR motif; other site 251229001035 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 251229001036 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 251229001037 active site 251229001038 dimerization interface [polypeptide binding]; other site 251229001039 Staphylococcal nuclease homologues; Region: SNc; smart00318 251229001040 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 251229001041 Catalytic site; other site 251229001042 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 251229001043 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251229001044 catalytic loop [active] 251229001045 iron binding site [ion binding]; other site 251229001046 Hemerythrin-like domain; Region: Hr-like; cd12108 251229001047 Fe binding site [ion binding]; other site 251229001048 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 251229001049 Predicted membrane protein [Function unknown]; Region: COG4244 251229001050 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 251229001051 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 251229001052 V4R domain; Region: V4R; pfam02830 251229001053 Phycobilisome protein; Region: Phycobilisome; cl08227 251229001054 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 251229001055 V4R domain; Region: V4R; pfam02830 251229001056 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 251229001057 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251229001058 catalytic loop [active] 251229001059 iron binding site [ion binding]; other site 251229001060 Phycobilisome protein; Region: Phycobilisome; cl08227 251229001061 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229001062 TPR motif; other site 251229001063 TPR repeat; Region: TPR_11; pfam13414 251229001064 binding surface 251229001065 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229001066 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229001067 active site 251229001068 ATP binding site [chemical binding]; other site 251229001069 substrate binding site [chemical binding]; other site 251229001070 activation loop (A-loop); other site 251229001071 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 251229001072 dimer interface [polypeptide binding]; other site 251229001073 ADP-ribose binding site [chemical binding]; other site 251229001074 active site 251229001075 nudix motif; other site 251229001076 metal binding site [ion binding]; metal-binding site 251229001077 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 251229001078 catalytic center binding site [active] 251229001079 ATP binding site [chemical binding]; other site 251229001080 Transglycosylase; Region: Transgly; pfam00912 251229001081 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 251229001082 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 251229001083 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 251229001084 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 251229001085 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 251229001086 EamA-like transporter family; Region: EamA; pfam00892 251229001087 EamA-like transporter family; Region: EamA; pfam00892 251229001088 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 251229001089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229001090 active site 251229001091 motif I; other site 251229001092 motif II; other site 251229001093 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 251229001094 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 251229001095 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 251229001096 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 251229001097 putative active site [active] 251229001098 putative NTP binding site [chemical binding]; other site 251229001099 putative nucleic acid binding site [nucleotide binding]; other site 251229001100 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 251229001101 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 251229001102 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 251229001103 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 251229001104 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 251229001105 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 251229001106 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229001107 TPR motif; other site 251229001108 binding surface 251229001109 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 251229001110 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 251229001111 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229001112 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 251229001113 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229001114 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 251229001115 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 251229001116 Ligand binding site; other site 251229001117 Putative Catalytic site; other site 251229001118 DXD motif; other site 251229001119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 251229001120 conserved repeat domain; Region: B_ant_repeat; TIGR01451 251229001121 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 251229001122 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 251229001123 Domain of unknown function DUF11; Region: DUF11; cl17728 251229001124 conserved repeat domain; Region: B_ant_repeat; TIGR01451 251229001125 Domain of unknown function DUF11; Region: DUF11; cl17728 251229001126 Domain of unknown function DUF11; Region: DUF11; pfam01345 251229001127 Right handed beta helix region; Region: Beta_helix; pfam13229 251229001128 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229001129 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229001130 active site 251229001131 ATP binding site [chemical binding]; other site 251229001132 substrate binding site [chemical binding]; other site 251229001133 activation loop (A-loop); other site 251229001134 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229001135 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229001136 structural tetrad; other site 251229001137 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 251229001138 Transposase IS200 like; Region: Y1_Tnp; cl00848 251229001139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229001140 TPR repeat; Region: TPR_11; pfam13414 251229001141 TPR motif; other site 251229001142 GUN4-like; Region: GUN4; pfam05419 251229001143 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 251229001144 HSP70 interaction site [polypeptide binding]; other site 251229001145 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 251229001146 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 251229001147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251229001148 FeS/SAM binding site; other site 251229001149 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 251229001150 Zn2+ binding site [ion binding]; other site 251229001151 Mg2+ binding site [ion binding]; other site 251229001152 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 251229001153 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 251229001154 L-asparaginase II; Region: Asparaginase_II; cl01842 251229001155 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 251229001156 G1 box; other site 251229001157 GTP/Mg2+ binding site [chemical binding]; other site 251229001158 G2 box; other site 251229001159 Switch I region; other site 251229001160 G3 box; other site 251229001161 Switch II region; other site 251229001162 G4 box; other site 251229001163 G5 box; other site 251229001164 Domain of unknown function (DUF697); Region: DUF697; pfam05128 251229001165 FG-GAP repeat; Region: FG-GAP_2; pfam14312 251229001166 FG-GAP repeat; Region: FG-GAP_2; pfam14312 251229001167 FG-GAP repeat; Region: FG-GAP_2; pfam14312 251229001168 PIN domain; Region: PIN; pfam01850 251229001169 putative active site [active] 251229001170 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 251229001171 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 251229001172 active site 251229001173 dimer interface [polypeptide binding]; other site 251229001174 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 251229001175 Ligand Binding Site [chemical binding]; other site 251229001176 Molecular Tunnel; other site 251229001177 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 251229001178 aspartate racemase; Region: asp_race; TIGR00035 251229001179 hypothetical protein; Provisional; Region: PRK06185 251229001180 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 251229001181 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 251229001182 putative phosphoketolase; Provisional; Region: PRK05261 251229001183 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 251229001184 TPP-binding site; other site 251229001185 XFP C-terminal domain; Region: XFP_C; pfam09363 251229001186 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 251229001187 homodimer interface [polypeptide binding]; other site 251229001188 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 251229001189 active site pocket [active] 251229001190 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 251229001191 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 251229001192 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 251229001193 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 251229001194 catalytic core [active] 251229001195 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229001196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229001197 S-adenosylmethionine binding site [chemical binding]; other site 251229001198 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 251229001199 propionate/acetate kinase; Provisional; Region: PRK12379 251229001200 TPR repeat; Region: TPR_11; pfam13414 251229001201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229001202 binding surface 251229001203 TPR motif; other site 251229001204 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 251229001205 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 251229001206 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 251229001207 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 251229001208 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 251229001209 metal binding site [ion binding]; metal-binding site 251229001210 S-layer homology domain; Region: SLH; pfam00395 251229001211 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251229001212 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 251229001213 dimer interface [polypeptide binding]; other site 251229001214 active site 251229001215 Schiff base residues; other site 251229001216 Tic20-like protein; Region: Tic20; pfam09685 251229001217 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 251229001218 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 251229001219 G1 box; other site 251229001220 putative GEF interaction site [polypeptide binding]; other site 251229001221 GTP/Mg2+ binding site [chemical binding]; other site 251229001222 Switch I region; other site 251229001223 G2 box; other site 251229001224 G3 box; other site 251229001225 Switch II region; other site 251229001226 G4 box; other site 251229001227 G5 box; other site 251229001228 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 251229001229 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251229001230 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 251229001231 active site 251229001232 catalytic tetrad [active] 251229001233 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 251229001234 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 251229001235 active site residue [active] 251229001236 light-harvesting-like protein 3; Provisional; Region: PLN00014 251229001237 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229001238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 251229001239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229001240 ATP binding site [chemical binding]; other site 251229001241 Mg2+ binding site [ion binding]; other site 251229001242 G-X-G motif; other site 251229001243 cyclase homology domain; Region: CHD; cd07302 251229001244 nucleotidyl binding site; other site 251229001245 metal binding site [ion binding]; metal-binding site 251229001246 dimer interface [polypeptide binding]; other site 251229001247 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 251229001248 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 251229001249 Rab subfamily motif 1 (RabSF1); other site 251229001250 G1 box; other site 251229001251 GTP/Mg2+ binding site [chemical binding]; other site 251229001252 Rab subfamily motif 2 (RabSF2); other site 251229001253 Switch I region; other site 251229001254 G2 box; other site 251229001255 effector interaction site; other site 251229001256 GDI interaction site; other site 251229001257 Rab family motif 1 (RabF1); other site 251229001258 GEF interaction site [polypeptide binding]; other site 251229001259 Rab family motif 2 (RabF2); other site 251229001260 G3 box; other site 251229001261 Switch II region; other site 251229001262 Rab family motif 3 (RabF3); other site 251229001263 Rab family motif 4 (RabF4); other site 251229001264 Rab family motif 5 (RabF5); other site 251229001265 Rab subfamily motif 3 (RabSF3); other site 251229001266 G4 box; other site 251229001267 G5 box; other site 251229001268 Rab subfamily motif 4 (RabSF4); other site 251229001269 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 251229001270 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 251229001271 ligand binding site [chemical binding]; other site 251229001272 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 251229001273 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 251229001274 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 251229001275 substrate binding site [chemical binding]; other site 251229001276 glutamase interaction surface [polypeptide binding]; other site 251229001277 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 251229001278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229001279 Walker A motif; other site 251229001280 ATP binding site [chemical binding]; other site 251229001281 Walker B motif; other site 251229001282 arginine finger; other site 251229001283 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 251229001284 TPR repeat; Region: TPR_11; pfam13414 251229001285 TPR repeat; Region: TPR_11; pfam13414 251229001286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229001287 binding surface 251229001288 TPR motif; other site 251229001289 TPR repeat; Region: TPR_11; pfam13414 251229001290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229001291 binding surface 251229001292 TPR motif; other site 251229001293 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 251229001294 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 251229001295 Walker A/P-loop; other site 251229001296 ATP binding site [chemical binding]; other site 251229001297 Q-loop/lid; other site 251229001298 ABC transporter signature motif; other site 251229001299 Walker B; other site 251229001300 D-loop; other site 251229001301 H-loop/switch region; other site 251229001302 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 251229001303 putative active site [active] 251229001304 AMIN domain; Region: AMIN; pfam11741 251229001305 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251229001306 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229001307 N-terminal plug; other site 251229001308 ligand-binding site [chemical binding]; other site 251229001309 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251229001310 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229001311 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 251229001312 tartrate dehydrogenase; Region: TTC; TIGR02089 251229001313 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 251229001314 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 251229001315 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 251229001316 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 251229001317 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 251229001318 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 251229001319 cytochrome c-550; Provisional; Region: psbV; PRK13618 251229001320 cytochrome c-550; Provisional; Region: psbV; PRK13621 251229001321 cytochrome c-550; Provisional; Region: psbV; cl17239 251229001322 Putative cyclase; Region: Cyclase; pfam04199 251229001323 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 251229001324 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 251229001325 RNA binding site [nucleotide binding]; other site 251229001326 active site 251229001327 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 251229001328 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251229001329 Ligand Binding Site [chemical binding]; other site 251229001330 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 251229001331 histidinol dehydrogenase; Region: hisD; TIGR00069 251229001332 NAD binding site [chemical binding]; other site 251229001333 dimerization interface [polypeptide binding]; other site 251229001334 product binding site; other site 251229001335 substrate binding site [chemical binding]; other site 251229001336 zinc binding site [ion binding]; other site 251229001337 catalytic residues [active] 251229001338 ribosomal protein S20; Region: rps20; CHL00102 251229001339 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 251229001340 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 251229001341 active site 251229001342 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 251229001343 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 251229001344 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 251229001345 RPB1 interaction site [polypeptide binding]; other site 251229001346 RPB10 interaction site [polypeptide binding]; other site 251229001347 RPB11 interaction site [polypeptide binding]; other site 251229001348 RPB3 interaction site [polypeptide binding]; other site 251229001349 RPB12 interaction site [polypeptide binding]; other site 251229001350 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 251229001351 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 251229001352 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 251229001353 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 251229001354 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 251229001355 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 251229001356 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 251229001357 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 251229001358 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 251229001359 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 251229001360 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 251229001361 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 251229001362 DNA binding site [nucleotide binding] 251229001363 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 251229001364 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 251229001365 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 251229001366 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 251229001367 protein binding site [polypeptide binding]; other site 251229001368 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 251229001369 putative homodimer interface [polypeptide binding]; other site 251229001370 putative homotetramer interface [polypeptide binding]; other site 251229001371 putative metal binding site [ion binding]; other site 251229001372 putative homodimer-homodimer interface [polypeptide binding]; other site 251229001373 putative allosteric switch controlling residues; other site 251229001374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229001375 S-adenosylmethionine binding site [chemical binding]; other site 251229001376 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 251229001377 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 251229001378 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 251229001379 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 251229001380 active site 251229001381 SAM binding site [chemical binding]; other site 251229001382 homodimer interface [polypeptide binding]; other site 251229001383 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 251229001384 ABC1 family; Region: ABC1; cl17513 251229001385 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 251229001386 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 251229001387 Zn binding site [ion binding]; other site 251229001388 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 251229001389 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 251229001390 cofactor binding site; other site 251229001391 DNA binding site [nucleotide binding] 251229001392 substrate interaction site [chemical binding]; other site 251229001393 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 251229001394 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 251229001395 TPP-binding site [chemical binding]; other site 251229001396 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 251229001397 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 251229001398 Cytochrome P450; Region: p450; pfam00067 251229001399 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 251229001400 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 251229001401 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 251229001402 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 251229001403 putative active site [active] 251229001404 putative substrate binding site [chemical binding]; other site 251229001405 putative cosubstrate binding site; other site 251229001406 catalytic site [active] 251229001407 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 251229001408 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 251229001409 catalytic residues [active] 251229001410 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 251229001411 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 251229001412 NAD(P) binding site [chemical binding]; other site 251229001413 homotetramer interface [polypeptide binding]; other site 251229001414 homodimer interface [polypeptide binding]; other site 251229001415 active site 251229001416 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 251229001417 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 251229001418 ring oligomerisation interface [polypeptide binding]; other site 251229001419 ATP/Mg binding site [chemical binding]; other site 251229001420 stacking interactions; other site 251229001421 hinge regions; other site 251229001422 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 251229001423 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 251229001424 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 251229001425 dimerization interface [polypeptide binding]; other site 251229001426 putative ATP binding site [chemical binding]; other site 251229001427 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 251229001428 EamA-like transporter family; Region: EamA; pfam00892 251229001429 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 251229001430 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 251229001431 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 251229001432 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 251229001433 DNA binding site [nucleotide binding] 251229001434 active site 251229001435 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 251229001436 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 251229001437 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 251229001438 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 251229001439 active site 251229001440 substrate binding site [chemical binding]; other site 251229001441 metal binding site [ion binding]; metal-binding site 251229001442 Predicted membrane protein [Function unknown]; Region: COG3431 251229001443 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 251229001444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229001445 Tetratricopeptide repeat; Region: TPR_16; pfam13432 251229001446 binding surface 251229001447 TPR motif; other site 251229001448 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251229001449 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229001450 binding surface 251229001451 TPR motif; other site 251229001452 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251229001453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 251229001454 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 251229001455 haemagglutination activity domain; Region: Haemagg_act; pfam05860 251229001456 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 251229001457 haemagglutination activity domain; Region: Haemagg_act; pfam05860 251229001458 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 251229001459 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 251229001460 CHASE2 domain; Region: CHASE2; pfam05226 251229001461 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229001462 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229001463 active site 251229001464 ATP binding site [chemical binding]; other site 251229001465 substrate binding site [chemical binding]; other site 251229001466 activation loop (A-loop); other site 251229001467 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 251229001468 5'-3' exonuclease; Region: 53EXOc; smart00475 251229001469 active site 251229001470 metal binding site 1 [ion binding]; metal-binding site 251229001471 putative 5' ssDNA interaction site; other site 251229001472 metal binding site 3; metal-binding site 251229001473 metal binding site 2 [ion binding]; metal-binding site 251229001474 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 251229001475 putative DNA binding site [nucleotide binding]; other site 251229001476 putative metal binding site [ion binding]; other site 251229001477 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 251229001478 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 251229001479 active site 251229001480 catalytic site [active] 251229001481 substrate binding site [chemical binding]; other site 251229001482 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 251229001483 active site 251229001484 DNA binding site [nucleotide binding] 251229001485 catalytic site [active] 251229001486 Epoxide hydrolase N terminus; Region: EHN; pfam06441 251229001487 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251229001488 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 251229001489 4-alpha-glucanotransferase; Provisional; Region: PRK14508 251229001490 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 251229001491 active site lid residues [active] 251229001492 substrate binding pocket [chemical binding]; other site 251229001493 catalytic residues [active] 251229001494 substrate-Mg2+ binding site; other site 251229001495 aspartate-rich region 1; other site 251229001496 aspartate-rich region 2; other site 251229001497 phytoene desaturase; Region: phytoene_desat; TIGR02731 251229001498 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229001499 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 251229001500 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 251229001501 metal ion-dependent adhesion site (MIDAS); other site 251229001502 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 251229001503 catalytic residues [active] 251229001504 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 251229001505 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 251229001506 RNA/DNA hybrid binding site [nucleotide binding]; other site 251229001507 active site 251229001508 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 251229001509 active site 251229001510 Predicted membrane protein [Function unknown]; Region: COG2324 251229001511 YcfA-like protein; Region: YcfA; pfam07927 251229001512 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 251229001513 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229001514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229001515 S-adenosylmethionine binding site [chemical binding]; other site 251229001516 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 251229001517 AAA domain; Region: AAA_26; pfam13500 251229001518 Protein kinase domain; Region: Pkinase; pfam00069 251229001519 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229001520 active site 251229001521 ATP binding site [chemical binding]; other site 251229001522 substrate binding site [chemical binding]; other site 251229001523 activation loop (A-loop); other site 251229001524 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 251229001525 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 251229001526 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 251229001527 active site 251229001528 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 251229001529 nudix motif; other site 251229001530 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 251229001531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229001532 TPR repeat; Region: TPR_11; pfam13414 251229001533 binding surface 251229001534 TPR motif; other site 251229001535 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 251229001536 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 251229001537 Walker A/P-loop; other site 251229001538 ATP binding site [chemical binding]; other site 251229001539 Q-loop/lid; other site 251229001540 ABC transporter signature motif; other site 251229001541 Walker B; other site 251229001542 D-loop; other site 251229001543 H-loop/switch region; other site 251229001544 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 251229001545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229001546 S-adenosylmethionine binding site [chemical binding]; other site 251229001547 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229001548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229001549 S-adenosylmethionine binding site [chemical binding]; other site 251229001550 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229001551 active site 251229001552 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 251229001553 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 251229001554 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 251229001555 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 251229001556 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251229001557 active site 251229001558 catalytic tetrad [active] 251229001559 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 251229001560 tetramer (dimer of dimers) interface [polypeptide binding]; other site 251229001561 active site 251229001562 dimer interface [polypeptide binding]; other site 251229001563 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 251229001564 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229001565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229001566 active site 251229001567 phosphorylation site [posttranslational modification] 251229001568 intermolecular recognition site; other site 251229001569 dimerization interface [polypeptide binding]; other site 251229001570 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229001571 DNA binding site [nucleotide binding] 251229001572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229001573 dimer interface [polypeptide binding]; other site 251229001574 phosphorylation site [posttranslational modification] 251229001575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229001576 ATP binding site [chemical binding]; other site 251229001577 Mg2+ binding site [ion binding]; other site 251229001578 G-X-G motif; other site 251229001579 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 251229001580 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229001581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229001582 S-adenosylmethionine binding site [chemical binding]; other site 251229001583 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 251229001584 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 251229001585 putative integrin binding motif; other site 251229001586 PA/protease domain interface [polypeptide binding]; other site 251229001587 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 251229001588 Peptidase family M28; Region: Peptidase_M28; pfam04389 251229001589 metal binding site [ion binding]; metal-binding site 251229001590 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 251229001591 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 251229001592 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 251229001593 protein binding site [polypeptide binding]; other site 251229001594 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 251229001595 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 251229001596 HSP70 interaction site [polypeptide binding]; other site 251229001597 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 251229001598 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 251229001599 oligomer interface [polypeptide binding]; other site 251229001600 metal binding site [ion binding]; metal-binding site 251229001601 metal binding site [ion binding]; metal-binding site 251229001602 Cl binding site [ion binding]; other site 251229001603 aspartate ring; other site 251229001604 basic sphincter; other site 251229001605 putative hydrophobic gate; other site 251229001606 periplasmic entrance; other site 251229001607 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 251229001608 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229001609 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229001610 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229001611 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229001612 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229001613 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229001614 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 251229001615 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 251229001616 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 251229001617 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 251229001618 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 251229001619 ChaB; Region: ChaB; pfam06150 251229001620 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 251229001621 Rubredoxin; Region: Rubredoxin; pfam00301 251229001622 iron binding site [ion binding]; other site 251229001623 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 251229001624 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 251229001625 Walker A/P-loop; other site 251229001626 ATP binding site [chemical binding]; other site 251229001627 Q-loop/lid; other site 251229001628 ABC transporter signature motif; other site 251229001629 Walker B; other site 251229001630 D-loop; other site 251229001631 H-loop/switch region; other site 251229001632 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 251229001633 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 251229001634 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 251229001635 putative ligand binding site [chemical binding]; other site 251229001636 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 251229001637 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 251229001638 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 251229001639 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 251229001640 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 251229001641 adenylosuccinate lyase; Provisional; Region: PRK07380 251229001642 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 251229001643 tetramer interface [polypeptide binding]; other site 251229001644 active site 251229001645 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 251229001646 short chain dehydrogenase; Provisional; Region: PRK06701 251229001647 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 251229001648 NAD binding site [chemical binding]; other site 251229001649 metal binding site [ion binding]; metal-binding site 251229001650 active site 251229001651 ATP-grasp domain; Region: ATP-grasp_4; cl17255 251229001652 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 251229001653 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 251229001654 NAD binding site [chemical binding]; other site 251229001655 homotetramer interface [polypeptide binding]; other site 251229001656 homodimer interface [polypeptide binding]; other site 251229001657 substrate binding site [chemical binding]; other site 251229001658 active site 251229001659 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251229001660 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 251229001661 ligand binding site [chemical binding]; other site 251229001662 flexible hinge region; other site 251229001663 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 251229001664 putative switch regulator; other site 251229001665 non-specific DNA interactions [nucleotide binding]; other site 251229001666 DNA binding site [nucleotide binding] 251229001667 sequence specific DNA binding site [nucleotide binding]; other site 251229001668 putative cAMP binding site [chemical binding]; other site 251229001669 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 251229001670 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 251229001671 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 251229001672 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 251229001673 Dynamin family; Region: Dynamin_N; pfam00350 251229001674 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 251229001675 G1 box; other site 251229001676 GTP/Mg2+ binding site [chemical binding]; other site 251229001677 Switch I region; other site 251229001678 G2 box; other site 251229001679 Switch II region; other site 251229001680 G3 box; other site 251229001681 G4 box; other site 251229001682 G5 box; other site 251229001683 Domain of unknown function (DUF697); Region: DUF697; pfam05128 251229001684 Conserved TM helix; Region: TM_helix; pfam05552 251229001685 Conserved TM helix; Region: TM_helix; pfam05552 251229001686 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 251229001687 hydrophobic ligand binding site; other site 251229001688 Uncharacterized conserved protein [Function unknown]; Region: COG2912 251229001689 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 251229001690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229001691 binding surface 251229001692 TPR motif; other site 251229001693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229001694 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229001695 dimerization interface [polypeptide binding]; other site 251229001696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229001697 dimer interface [polypeptide binding]; other site 251229001698 phosphorylation site [posttranslational modification] 251229001699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229001700 ATP binding site [chemical binding]; other site 251229001701 Mg2+ binding site [ion binding]; other site 251229001702 G-X-G motif; other site 251229001703 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229001704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229001705 active site 251229001706 phosphorylation site [posttranslational modification] 251229001707 intermolecular recognition site; other site 251229001708 dimerization interface [polypeptide binding]; other site 251229001709 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229001710 DNA binding site [nucleotide binding] 251229001711 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 251229001712 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 251229001713 Ligand binding site; other site 251229001714 Putative Catalytic site; other site 251229001715 DXD motif; other site 251229001716 Pectic acid lyase; Region: Pec_lyase; pfam09492 251229001717 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 251229001718 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251229001719 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 251229001720 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251229001721 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 251229001722 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 251229001723 Uncharacterized conserved protein [Function unknown]; Region: COG0432 251229001724 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 251229001725 Domain of unknown function DUF20; Region: UPF0118; pfam01594 251229001726 Predicted integral membrane protein [Function unknown]; Region: COG0762 251229001727 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 251229001728 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 251229001729 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 251229001730 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 251229001731 Protein of unknown function (DUF98); Region: DUF98; pfam01947 251229001732 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 251229001733 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229001734 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 251229001735 Walker A/P-loop; other site 251229001736 ATP binding site [chemical binding]; other site 251229001737 Q-loop/lid; other site 251229001738 ABC transporter signature motif; other site 251229001739 Walker B; other site 251229001740 D-loop; other site 251229001741 H-loop/switch region; other site 251229001742 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 251229001743 FAD binding domain; Region: FAD_binding_4; pfam01565 251229001744 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 251229001745 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 251229001746 homooctamer interface [polypeptide binding]; other site 251229001747 active site 251229001748 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 251229001749 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 251229001750 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 251229001751 ring oligomerisation interface [polypeptide binding]; other site 251229001752 ATP/Mg binding site [chemical binding]; other site 251229001753 stacking interactions; other site 251229001754 hinge regions; other site 251229001755 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 251229001756 oligomerisation interface [polypeptide binding]; other site 251229001757 mobile loop; other site 251229001758 roof hairpin; other site 251229001759 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 251229001760 dimer interface [polypeptide binding]; other site 251229001761 [2Fe-2S] cluster binding site [ion binding]; other site 251229001762 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251229001763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229001764 active site 251229001765 phosphorylation site [posttranslational modification] 251229001766 intermolecular recognition site; other site 251229001767 dimerization interface [polypeptide binding]; other site 251229001768 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251229001769 DNA binding residues [nucleotide binding] 251229001770 dimerization interface [polypeptide binding]; other site 251229001771 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 251229001772 HSP70 interaction site [polypeptide binding]; other site 251229001773 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229001774 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229001775 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229001776 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229001777 Uncharacterized conserved protein [Function unknown]; Region: COG1801 251229001778 CHD5-like protein; Region: CHD5; pfam04420 251229001779 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 251229001780 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 251229001781 FMN binding site [chemical binding]; other site 251229001782 active site 251229001783 substrate binding site [chemical binding]; other site 251229001784 catalytic residue [active] 251229001785 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 251229001786 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 251229001787 catalytic residues [active] 251229001788 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251229001789 dimerization interface [polypeptide binding]; other site 251229001790 putative DNA binding site [nucleotide binding]; other site 251229001791 putative Zn2+ binding site [ion binding]; other site 251229001792 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 251229001793 elongation factor G; Reviewed; Region: PRK12740 251229001794 G1 box; other site 251229001795 putative GEF interaction site [polypeptide binding]; other site 251229001796 GTP/Mg2+ binding site [chemical binding]; other site 251229001797 Switch I region; other site 251229001798 G2 box; other site 251229001799 G3 box; other site 251229001800 Switch II region; other site 251229001801 G4 box; other site 251229001802 G5 box; other site 251229001803 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 251229001804 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 251229001805 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 251229001806 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 251229001807 C-terminal peptidase (prc); Region: prc; TIGR00225 251229001808 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 251229001809 protein binding site [polypeptide binding]; other site 251229001810 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 251229001811 Catalytic dyad [active] 251229001812 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 251229001813 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 251229001814 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 251229001815 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 251229001816 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 251229001817 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229001818 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 251229001819 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229001820 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229001821 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229001822 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 251229001823 putative ADP-binding pocket [chemical binding]; other site 251229001824 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229001825 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229001826 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 251229001827 putative active site [active] 251229001828 Uncharacterized integral membrane protein [Function unknown]; Region: COG5413 251229001829 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 251229001830 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 251229001831 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 251229001832 arogenate dehydrogenase; Reviewed; Region: PRK07417 251229001833 prephenate dehydrogenase; Validated; Region: PRK08507 251229001834 Uncharacterized conserved protein [Function unknown]; Region: COG1434 251229001835 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 251229001836 putative active site [active] 251229001837 PAS domain; Region: PAS; smart00091 251229001838 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251229001839 putative active site [active] 251229001840 heme pocket [chemical binding]; other site 251229001841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229001842 dimer interface [polypeptide binding]; other site 251229001843 phosphorylation site [posttranslational modification] 251229001844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229001845 ATP binding site [chemical binding]; other site 251229001846 Mg2+ binding site [ion binding]; other site 251229001847 G-X-G motif; other site 251229001848 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 251229001849 Chemotaxis phosphatase CheX; Region: CheX; cl15816 251229001850 Response regulator receiver domain; Region: Response_reg; pfam00072 251229001851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229001852 active site 251229001853 phosphorylation site [posttranslational modification] 251229001854 intermolecular recognition site; other site 251229001855 dimerization interface [polypeptide binding]; other site 251229001856 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 251229001857 putative binding surface; other site 251229001858 active site 251229001859 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 251229001860 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 251229001861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229001862 ATP binding site [chemical binding]; other site 251229001863 Mg2+ binding site [ion binding]; other site 251229001864 G-X-G motif; other site 251229001865 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 251229001866 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 251229001867 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 251229001868 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229001869 dimerization interface [polypeptide binding]; other site 251229001870 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 251229001871 dimer interface [polypeptide binding]; other site 251229001872 putative CheW interface [polypeptide binding]; other site 251229001873 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 251229001874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229001875 active site 251229001876 phosphorylation site [posttranslational modification] 251229001877 intermolecular recognition site; other site 251229001878 dimerization interface [polypeptide binding]; other site 251229001879 CheB methylesterase; Region: CheB_methylest; pfam01339 251229001880 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 251229001881 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 251229001882 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 251229001883 proton extrusion protein PcxA; Provisional; Region: PRK02507 251229001884 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 251229001885 FAD binding site [chemical binding]; other site 251229001886 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 251229001887 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 251229001888 active site 251229001889 HIGH motif; other site 251229001890 dimer interface [polypeptide binding]; other site 251229001891 KMSKS motif; other site 251229001892 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 251229001893 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 251229001894 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 251229001895 Walker A/P-loop; other site 251229001896 ATP binding site [chemical binding]; other site 251229001897 Q-loop/lid; other site 251229001898 ABC transporter signature motif; other site 251229001899 Walker B; other site 251229001900 D-loop; other site 251229001901 H-loop/switch region; other site 251229001902 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 251229001903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229001904 dimer interface [polypeptide binding]; other site 251229001905 conserved gate region; other site 251229001906 putative PBP binding loops; other site 251229001907 ABC-ATPase subunit interface; other site 251229001908 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 251229001909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229001910 dimer interface [polypeptide binding]; other site 251229001911 conserved gate region; other site 251229001912 putative PBP binding loops; other site 251229001913 ABC-ATPase subunit interface; other site 251229001914 PBP superfamily domain; Region: PBP_like_2; cl17296 251229001915 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 251229001916 L-aspartate oxidase; Provisional; Region: PRK06175 251229001917 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 251229001918 Predicted membrane protein [Function unknown]; Region: COG2119 251229001919 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 251229001920 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 251229001921 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229001922 putative active site [active] 251229001923 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 251229001924 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229001925 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251229001926 Ligand Binding Site [chemical binding]; other site 251229001927 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 251229001928 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 251229001929 active site 251229001930 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 251229001931 hypothetical protein; Reviewed; Region: PRK12497 251229001932 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229001933 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229001934 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229001935 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229001936 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 251229001937 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 251229001938 putative NAD(P) binding site [chemical binding]; other site 251229001939 putative substrate binding site [chemical binding]; other site 251229001940 catalytic Zn binding site [ion binding]; other site 251229001941 structural Zn binding site [ion binding]; other site 251229001942 dimer interface [polypeptide binding]; other site 251229001943 DNA primase; Validated; Region: dnaG; PRK05667 251229001944 CHC2 zinc finger; Region: zf-CHC2; pfam01807 251229001945 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 251229001946 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 251229001947 active site 251229001948 metal binding site [ion binding]; metal-binding site 251229001949 interdomain interaction site; other site 251229001950 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 251229001951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229001952 S-adenosylmethionine binding site [chemical binding]; other site 251229001953 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 251229001954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229001955 Walker A motif; other site 251229001956 ATP binding site [chemical binding]; other site 251229001957 Walker B motif; other site 251229001958 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251229001959 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251229001960 ligand binding site [chemical binding]; other site 251229001961 flexible hinge region; other site 251229001962 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 251229001963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 251229001964 Walker A motif; other site 251229001965 ATP binding site [chemical binding]; other site 251229001966 Walker B motif; other site 251229001967 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 251229001968 4Fe-4S binding domain; Region: Fer4_5; pfam12801 251229001969 4Fe-4S binding domain; Region: Fer4_5; pfam12801 251229001970 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 251229001971 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 251229001972 substrate binding pocket [chemical binding]; other site 251229001973 chain length determination region; other site 251229001974 substrate-Mg2+ binding site; other site 251229001975 catalytic residues [active] 251229001976 aspartate-rich region 1; other site 251229001977 active site lid residues [active] 251229001978 aspartate-rich region 2; other site 251229001979 glutamate racemase; Provisional; Region: PRK00865 251229001980 AMIN domain; Region: AMIN; pfam11741 251229001981 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 251229001982 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 251229001983 active site 251229001984 metal binding site [ion binding]; metal-binding site 251229001985 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 251229001986 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 251229001987 Response regulator receiver domain; Region: Response_reg; pfam00072 251229001988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229001989 active site 251229001990 phosphorylation site [posttranslational modification] 251229001991 intermolecular recognition site; other site 251229001992 dimerization interface [polypeptide binding]; other site 251229001993 lipoyl synthase; Provisional; Region: PRK12928 251229001994 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251229001995 FeS/SAM binding site; other site 251229001996 PsaX family; Region: PsaX; pfam08078 251229001997 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 251229001998 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 251229001999 TM-ABC transporter signature motif; other site 251229002000 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229002001 putative active site [active] 251229002002 PAS fold; Region: PAS_3; pfam08447 251229002003 heme pocket [chemical binding]; other site 251229002004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229002005 putative active site [active] 251229002006 heme pocket [chemical binding]; other site 251229002007 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229002008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229002009 dimer interface [polypeptide binding]; other site 251229002010 phosphorylation site [posttranslational modification] 251229002011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229002012 ATP binding site [chemical binding]; other site 251229002013 Mg2+ binding site [ion binding]; other site 251229002014 G-X-G motif; other site 251229002015 Response regulator receiver domain; Region: Response_reg; pfam00072 251229002016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229002017 active site 251229002018 phosphorylation site [posttranslational modification] 251229002019 intermolecular recognition site; other site 251229002020 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229002021 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229002022 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229002023 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229002024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229002025 dimer interface [polypeptide binding]; other site 251229002026 phosphorylation site [posttranslational modification] 251229002027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229002028 ATP binding site [chemical binding]; other site 251229002029 Mg2+ binding site [ion binding]; other site 251229002030 G-X-G motif; other site 251229002031 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 251229002032 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 251229002033 Ligand Binding Site [chemical binding]; other site 251229002034 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229002035 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229002036 Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335 251229002037 catalytic triad [active] 251229002038 conserved cis-peptide bond; other site 251229002039 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 251229002040 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 251229002041 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 251229002042 short chain dehydrogenase; Provisional; Region: PRK12367 251229002043 NAD(P) binding site [chemical binding]; other site 251229002044 Predicted methyltransferases [General function prediction only]; Region: COG0313 251229002045 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 251229002046 putative SAM binding site [chemical binding]; other site 251229002047 putative homodimer interface [polypeptide binding]; other site 251229002048 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 251229002049 pheophytin binding site; other site 251229002050 chlorophyll binding site; other site 251229002051 quinone binding site; other site 251229002052 Fe binding site [ion binding]; other site 251229002053 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 251229002054 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 251229002055 mce related protein; Region: MCE; pfam02470 251229002056 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 251229002057 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 251229002058 Walker A/P-loop; other site 251229002059 ATP binding site [chemical binding]; other site 251229002060 Q-loop/lid; other site 251229002061 ABC transporter signature motif; other site 251229002062 Walker B; other site 251229002063 D-loop; other site 251229002064 H-loop/switch region; other site 251229002065 carotene isomerase; Region: carot_isom; TIGR02730 251229002066 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229002067 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 251229002068 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 251229002069 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229002070 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 251229002071 homotrimer interaction site [polypeptide binding]; other site 251229002072 putative active site [active] 251229002073 Caspase domain; Region: Peptidase_C14; pfam00656 251229002074 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229002075 structural tetrad; other site 251229002076 PQQ-like domain; Region: PQQ_2; pfam13360 251229002077 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 251229002078 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 251229002079 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 251229002080 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 251229002081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 251229002082 active site 251229002083 motif I; other site 251229002084 motif II; other site 251229002085 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 251229002086 RuvA N terminal domain; Region: RuvA_N; pfam01330 251229002087 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 251229002088 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 251229002089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229002090 dimer interface [polypeptide binding]; other site 251229002091 conserved gate region; other site 251229002092 ABC-ATPase subunit interface; other site 251229002093 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 251229002094 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 251229002095 nucleotide binding site [chemical binding]; other site 251229002096 Predicted integral membrane protein [Function unknown]; Region: COG5542 251229002097 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 251229002098 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 251229002099 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 251229002100 putative phosphate acyltransferase; Provisional; Region: PRK05331 251229002101 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 251229002102 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 251229002103 dimer interface [polypeptide binding]; other site 251229002104 active site 251229002105 CoA binding pocket [chemical binding]; other site 251229002106 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 251229002107 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 251229002108 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 251229002109 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 251229002110 putative acyl-acceptor binding pocket; other site 251229002111 Uncharacterized small conserved protein [Function unknown]; Region: COG5626 251229002112 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 251229002113 Domain of unknown function DUF20; Region: UPF0118; pfam01594 251229002114 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 251229002115 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 251229002116 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251229002117 extended (e) SDRs; Region: SDR_e; cd08946 251229002118 NAD(P) binding site [chemical binding]; other site 251229002119 substrate binding site [chemical binding]; other site 251229002120 active site 251229002121 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 251229002122 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 251229002123 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 251229002124 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 251229002125 active site 251229002126 catalytic triad [active] 251229002127 oxyanion hole [active] 251229002128 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 251229002129 active site 251229002130 catalytic triad [active] 251229002131 oxyanion hole [active] 251229002132 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 251229002133 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 251229002134 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 251229002135 trimer interface [polypeptide binding]; other site 251229002136 active site 251229002137 substrate binding site [chemical binding]; other site 251229002138 CoA binding site [chemical binding]; other site 251229002139 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229002140 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229002141 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229002142 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 251229002143 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 251229002144 Walker A/P-loop; other site 251229002145 ATP binding site [chemical binding]; other site 251229002146 Q-loop/lid; other site 251229002147 ABC transporter signature motif; other site 251229002148 Walker B; other site 251229002149 D-loop; other site 251229002150 H-loop/switch region; other site 251229002151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229002152 S-adenosylmethionine binding site [chemical binding]; other site 251229002153 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 251229002154 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229002155 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 251229002156 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 251229002157 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 251229002158 trimer interface [polypeptide binding]; other site 251229002159 active site 251229002160 substrate binding site [chemical binding]; other site 251229002161 CoA binding site [chemical binding]; other site 251229002162 Core-2/I-Branching enzyme; Region: Branch; pfam02485 251229002163 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 251229002164 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229002165 active site 251229002166 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 251229002167 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 251229002168 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 251229002169 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229002170 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 251229002171 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 251229002172 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 251229002173 acyl-activating enzyme (AAE) consensus motif; other site 251229002174 putative AMP binding site [chemical binding]; other site 251229002175 putative active site [active] 251229002176 putative CoA binding site [chemical binding]; other site 251229002177 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 251229002178 active sites [active] 251229002179 tetramer interface [polypeptide binding]; other site 251229002180 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 251229002181 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 251229002182 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 251229002183 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229002184 motif II; other site 251229002185 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 251229002186 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 251229002187 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 251229002188 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 251229002189 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 251229002190 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 251229002191 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 251229002192 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 251229002193 Ligand binding site; other site 251229002194 oligomer interface; other site 251229002195 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 251229002196 KpsF/GutQ family protein; Region: kpsF; TIGR00393 251229002197 putative active site [active] 251229002198 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 251229002199 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229002200 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 251229002201 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 251229002202 Protein of unknown function (DUF563); Region: DUF563; pfam04577 251229002203 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 251229002204 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 251229002205 active site 251229002206 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 251229002207 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 251229002208 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 251229002209 extended (e) SDRs; Region: SDR_e; cd08946 251229002210 NAD(P) binding site [chemical binding]; other site 251229002211 active site 251229002212 substrate binding site [chemical binding]; other site 251229002213 Protein of unknown function (DUF563); Region: DUF563; pfam04577 251229002214 Protein of unknown function (DUF563); Region: DUF563; pfam04577 251229002215 Protein of unknown function (DUF563); Region: DUF563; pfam04577 251229002216 Protein of unknown function (DUF563); Region: DUF563; pfam04577 251229002217 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 251229002218 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 251229002219 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 251229002220 substrate binding site; other site 251229002221 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 251229002222 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 251229002223 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 251229002224 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229002225 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 251229002226 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 251229002227 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229002228 active site 251229002229 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229002230 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229002231 Chain length determinant protein; Region: Wzz; cl15801 251229002232 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 251229002233 Chain length determinant protein; Region: Wzz; cl15801 251229002234 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 251229002235 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 251229002236 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229002237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229002238 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 251229002239 Dynamin family; Region: Dynamin_N; pfam00350 251229002240 G1 box; other site 251229002241 GTP/Mg2+ binding site [chemical binding]; other site 251229002242 G2 box; other site 251229002243 Switch I region; other site 251229002244 G3 box; other site 251229002245 Switch II region; other site 251229002246 G4 box; other site 251229002247 G5 box; other site 251229002248 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229002249 putative active site [active] 251229002250 Peptidase family M41; Region: Peptidase_M41; pfam01434 251229002251 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 251229002252 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 251229002253 catalytic triad [active] 251229002254 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 251229002255 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 251229002256 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 251229002257 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 251229002258 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 251229002259 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 251229002260 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 251229002261 putative active site [active] 251229002262 transaldolase; Provisional; Region: PRK03903 251229002263 catalytic residue [active] 251229002264 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 251229002265 AMP binding site [chemical binding]; other site 251229002266 metal binding site [ion binding]; metal-binding site 251229002267 active site 251229002268 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 251229002269 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 251229002270 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 251229002271 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 251229002272 protein-splicing catalytic site; other site 251229002273 thioester formation/cholesterol transfer; other site 251229002274 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 251229002275 Homing endonuclease; Region: Hom_end; pfam05204 251229002276 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 251229002277 hypothetical protein; Provisional; Region: PRK06185 251229002278 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 251229002279 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 251229002280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251229002281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 251229002282 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 251229002283 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 251229002284 HIGH motif; other site 251229002285 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 251229002286 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 251229002287 active site 251229002288 KMSKS motif; other site 251229002289 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 251229002290 tRNA binding surface [nucleotide binding]; other site 251229002291 anticodon binding site; other site 251229002292 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 251229002293 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 251229002294 ABC1 family; Region: ABC1; pfam03109 251229002295 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 251229002296 active site 251229002297 ATP binding site [chemical binding]; other site 251229002298 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 251229002299 TrkA-N domain; Region: TrkA_N; pfam02254 251229002300 TrkA-C domain; Region: TrkA_C; pfam02080 251229002301 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 251229002302 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 251229002303 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 251229002304 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 251229002305 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 251229002306 Walker A/P-loop; other site 251229002307 ATP binding site [chemical binding]; other site 251229002308 Q-loop/lid; other site 251229002309 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 251229002310 ABC transporter signature motif; other site 251229002311 Walker B; other site 251229002312 D-loop; other site 251229002313 H-loop/switch region; other site 251229002314 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 251229002315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229002316 Coenzyme A binding pocket [chemical binding]; other site 251229002317 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251229002318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229002319 active site 251229002320 phosphorylation site [posttranslational modification] 251229002321 intermolecular recognition site; other site 251229002322 dimerization interface [polypeptide binding]; other site 251229002323 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251229002324 DNA binding residues [nucleotide binding] 251229002325 dimerization interface [polypeptide binding]; other site 251229002326 Transcriptional regulator; Region: Rrf2; cl17282 251229002327 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 251229002328 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 251229002329 glutaminase active site [active] 251229002330 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 251229002331 dimer interface [polypeptide binding]; other site 251229002332 active site 251229002333 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 251229002334 dimer interface [polypeptide binding]; other site 251229002335 active site 251229002336 photosystem I subunit VII; Region: psaC; CHL00065 251229002337 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 251229002338 2-epi-5-epi-valiolone synthase (EEVS); Region: EEVS; cd08199 251229002339 active site 251229002340 metal binding site [ion binding]; metal-binding site 251229002341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 251229002342 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 251229002343 S-adenosylmethionine binding site [chemical binding]; other site 251229002344 hypothetical protein; Provisional; Region: PRK06849 251229002345 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 251229002346 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 251229002347 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 251229002348 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 251229002349 active site 251229002350 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 251229002351 dimer interface [polypeptide binding]; other site 251229002352 catalytic triad [active] 251229002353 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 251229002354 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229002355 motif II; other site 251229002356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 251229002357 Probable transposase; Region: OrfB_IS605; pfam01385 251229002358 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 251229002359 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 251229002360 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 251229002361 catalytic triad [active] 251229002362 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 251229002363 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 251229002364 Right handed beta helix region; Region: Beta_helix; pfam13229 251229002365 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229002366 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 251229002367 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229002368 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229002369 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 251229002370 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 251229002371 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229002372 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 251229002373 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229002374 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 251229002375 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229002376 active site 251229002377 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229002378 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229002379 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229002380 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229002381 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 251229002382 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 251229002383 inhibitor-cofactor binding pocket; inhibition site 251229002384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229002385 catalytic residue [active] 251229002386 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251229002387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229002388 NAD(P) binding site [chemical binding]; other site 251229002389 active site 251229002390 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 251229002391 trimer interface [polypeptide binding]; other site 251229002392 active site 251229002393 substrate binding site [chemical binding]; other site 251229002394 CoA binding site [chemical binding]; other site 251229002395 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 251229002396 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 251229002397 inhibitor-cofactor binding pocket; inhibition site 251229002398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229002399 catalytic residue [active] 251229002400 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 251229002401 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 251229002402 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 251229002403 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 251229002404 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 251229002405 putative trimer interface [polypeptide binding]; other site 251229002406 putative active site [active] 251229002407 putative substrate binding site [chemical binding]; other site 251229002408 putative CoA binding site [chemical binding]; other site 251229002409 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 251229002410 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 251229002411 Walker A/P-loop; other site 251229002412 ATP binding site [chemical binding]; other site 251229002413 Q-loop/lid; other site 251229002414 ABC transporter signature motif; other site 251229002415 Walker B; other site 251229002416 D-loop; other site 251229002417 H-loop/switch region; other site 251229002418 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 251229002419 putative carbohydrate binding site [chemical binding]; other site 251229002420 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 251229002421 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 251229002422 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 251229002423 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 251229002424 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 251229002425 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 251229002426 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 251229002427 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 251229002428 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 251229002429 active site 251229002430 HIGH motif; other site 251229002431 nucleotide binding site [chemical binding]; other site 251229002432 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 251229002433 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 251229002434 active site 251229002435 KMSKS motif; other site 251229002436 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 251229002437 tRNA binding surface [nucleotide binding]; other site 251229002438 anticodon binding site; other site 251229002439 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 251229002440 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 251229002441 haemagglutination activity domain; Region: Haemagg_act; pfam05860 251229002442 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 251229002443 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 251229002444 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 251229002445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229002446 S-adenosylmethionine binding site [chemical binding]; other site 251229002447 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 251229002448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229002449 S-adenosylmethionine binding site [chemical binding]; other site 251229002450 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 251229002451 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 251229002452 ligand binding site [chemical binding]; other site 251229002453 NAD binding site [chemical binding]; other site 251229002454 dimerization interface [polypeptide binding]; other site 251229002455 catalytic site [active] 251229002456 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 251229002457 putative L-serine binding site [chemical binding]; other site 251229002458 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229002459 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229002460 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 251229002461 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 251229002462 RNA binding surface [nucleotide binding]; other site 251229002463 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 251229002464 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229002465 NAD(P) binding site [chemical binding]; other site 251229002466 active site 251229002467 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 251229002468 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 251229002469 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251229002470 Ligand Binding Site [chemical binding]; other site 251229002471 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 251229002472 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 251229002473 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 251229002474 Subunit I/III interface [polypeptide binding]; other site 251229002475 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 251229002476 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 251229002477 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 251229002478 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 251229002479 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 251229002480 Predicted membrane protein [Function unknown]; Region: COG4244 251229002481 Predicted membrane protein [Function unknown]; Region: COG4244 251229002482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 251229002483 Probable transposase; Region: OrfB_IS605; pfam01385 251229002484 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 251229002485 Transposase IS200 like; Region: Y1_Tnp; pfam01797 251229002486 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 251229002487 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 251229002488 active site 251229002489 NTP binding site [chemical binding]; other site 251229002490 metal binding triad [ion binding]; metal-binding site 251229002491 antibiotic binding site [chemical binding]; other site 251229002492 Transcriptional regulator; Region: Rrf2; pfam02082 251229002493 Predicted transcriptional regulator [Transcription]; Region: COG1959 251229002494 methionine aminotransferase; Validated; Region: PRK09082 251229002495 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 251229002496 MgtC family; Region: MgtC; pfam02308 251229002497 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 251229002498 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 251229002499 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 251229002500 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 251229002501 N-terminal domain interface [polypeptide binding]; other site 251229002502 dimer interface [polypeptide binding]; other site 251229002503 substrate binding pocket (H-site) [chemical binding]; other site 251229002504 Putative phosphatase (DUF442); Region: DUF442; cl17385 251229002505 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 251229002506 Cytochrome P450; Region: p450; pfam00067 251229002507 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251229002508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 251229002509 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 251229002510 dimer interface [polypeptide binding]; other site 251229002511 FMN binding site [chemical binding]; other site 251229002512 NADPH bind site [chemical binding]; other site 251229002513 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 251229002514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229002515 Walker A/P-loop; other site 251229002516 ATP binding site [chemical binding]; other site 251229002517 Q-loop/lid; other site 251229002518 ABC transporter signature motif; other site 251229002519 Walker B; other site 251229002520 D-loop; other site 251229002521 H-loop/switch region; other site 251229002522 ABC-2 type transporter; Region: ABC2_membrane; cl17235 251229002523 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 251229002524 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 251229002525 MarR family; Region: MarR_2; pfam12802 251229002526 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251229002527 putative active site [active] 251229002528 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 251229002529 Uncharacterized conserved protein [Function unknown]; Region: COG2128 251229002530 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 251229002531 AIPR protein; Region: AIPR; pfam10592 251229002532 HEAT repeats; Region: HEAT_2; pfam13646 251229002533 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 251229002534 protein binding surface [polypeptide binding]; other site 251229002535 HEAT repeats; Region: HEAT_2; pfam13646 251229002536 HEAT repeats; Region: HEAT_2; pfam13646 251229002537 HEAT repeats; Region: HEAT_2; pfam13646 251229002538 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 251229002539 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 251229002540 active site 251229002541 catalytic triad [active] 251229002542 oxyanion hole [active] 251229002543 Peptidase family M48; Region: Peptidase_M48; pfam01435 251229002544 trehalose synthase; Region: treS_nterm; TIGR02456 251229002545 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 251229002546 active site 251229002547 catalytic site [active] 251229002548 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229002549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229002550 active site 251229002551 phosphorylation site [posttranslational modification] 251229002552 intermolecular recognition site; other site 251229002553 dimerization interface [polypeptide binding]; other site 251229002554 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229002555 DNA binding site [nucleotide binding] 251229002556 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229002557 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229002558 dimerization interface [polypeptide binding]; other site 251229002559 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229002560 dimer interface [polypeptide binding]; other site 251229002561 phosphorylation site [posttranslational modification] 251229002562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229002563 ATP binding site [chemical binding]; other site 251229002564 Mg2+ binding site [ion binding]; other site 251229002565 G-X-G motif; other site 251229002566 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 251229002567 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 251229002568 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229002569 active site 251229002570 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 251229002571 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229002572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229002573 Walker A/P-loop; other site 251229002574 ATP binding site [chemical binding]; other site 251229002575 Q-loop/lid; other site 251229002576 ABC transporter signature motif; other site 251229002577 Walker B; other site 251229002578 D-loop; other site 251229002579 H-loop/switch region; other site 251229002580 Phosphotransferase enzyme family; Region: APH; pfam01636 251229002581 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 251229002582 substrate binding site [chemical binding]; other site 251229002583 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 251229002584 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229002585 putative ADP-binding pocket [chemical binding]; other site 251229002586 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229002587 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 251229002588 trimer interface [polypeptide binding]; other site 251229002589 active site 251229002590 CoA binding site [chemical binding]; other site 251229002591 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 251229002592 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 251229002593 putative trimer interface [polypeptide binding]; other site 251229002594 putative CoA binding site [chemical binding]; other site 251229002595 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251229002596 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229002597 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251229002598 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 251229002599 FtsX-like permease family; Region: FtsX; pfam02687 251229002600 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 251229002601 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 251229002602 PemK-like protein; Region: PemK; pfam02452 251229002603 GUN4-like; Region: GUN4; pfam05419 251229002604 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 251229002605 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 251229002606 N- and C-terminal domain interface [polypeptide binding]; other site 251229002607 active site 251229002608 MgATP binding site [chemical binding]; other site 251229002609 catalytic site [active] 251229002610 metal binding site [ion binding]; metal-binding site 251229002611 glycerol binding site [chemical binding]; other site 251229002612 homotetramer interface [polypeptide binding]; other site 251229002613 homodimer interface [polypeptide binding]; other site 251229002614 FBP binding site [chemical binding]; other site 251229002615 protein IIAGlc interface [polypeptide binding]; other site 251229002616 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; cl01562 251229002617 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 251229002618 Cadmium resistance transporter; Region: Cad; pfam03596 251229002619 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 251229002620 active site 251229002621 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 251229002622 Domain of unknown function DUF21; Region: DUF21; pfam01595 251229002623 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 251229002624 Transporter associated domain; Region: CorC_HlyC; smart01091 251229002625 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 251229002626 Ligand Binding Site [chemical binding]; other site 251229002627 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 251229002628 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 251229002629 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 251229002630 phosphoenolpyruvate synthase; Validated; Region: PRK06241 251229002631 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 251229002632 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 251229002633 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 251229002634 NMT1-like family; Region: NMT1_2; pfam13379 251229002635 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 251229002636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229002637 dimer interface [polypeptide binding]; other site 251229002638 conserved gate region; other site 251229002639 putative PBP binding loops; other site 251229002640 ABC-ATPase subunit interface; other site 251229002641 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 251229002642 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 251229002643 Walker A/P-loop; other site 251229002644 ATP binding site [chemical binding]; other site 251229002645 Q-loop/lid; other site 251229002646 ABC transporter signature motif; other site 251229002647 Walker B; other site 251229002648 D-loop; other site 251229002649 H-loop/switch region; other site 251229002650 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 251229002651 NMT1-like family; Region: NMT1_2; pfam13379 251229002652 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 251229002653 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 251229002654 Walker A/P-loop; other site 251229002655 ATP binding site [chemical binding]; other site 251229002656 Q-loop/lid; other site 251229002657 ABC transporter signature motif; other site 251229002658 Walker B; other site 251229002659 D-loop; other site 251229002660 H-loop/switch region; other site 251229002661 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 251229002662 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 251229002663 Sulfate transporter family; Region: Sulfate_transp; pfam00916 251229002664 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 251229002665 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 251229002666 Predicted membrane protein [Function unknown]; Region: COG3431 251229002667 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08389 251229002668 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 251229002669 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 251229002670 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 251229002671 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 251229002672 hypothetical protein; Provisional; Region: PRK07377 251229002673 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 251229002674 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 251229002675 putative lipid kinase; Reviewed; Region: PRK13057 251229002676 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 251229002677 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 251229002678 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 251229002679 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 251229002680 active site 251229002681 homodimer interface [polypeptide binding]; other site 251229002682 catalytic site [active] 251229002683 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 251229002684 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 251229002685 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 251229002686 ligand binding site; other site 251229002687 oligomer interface; other site 251229002688 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 251229002689 dimer interface [polypeptide binding]; other site 251229002690 N-terminal domain interface [polypeptide binding]; other site 251229002691 sulfate 1 binding site; other site 251229002692 AAA domain; Region: AAA_33; pfam13671 251229002693 AAA domain; Region: AAA_17; pfam13207 251229002694 L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575 251229002695 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 251229002696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229002697 dimer interface [polypeptide binding]; other site 251229002698 conserved gate region; other site 251229002699 putative PBP binding loops; other site 251229002700 ABC-ATPase subunit interface; other site 251229002701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229002702 ABC-ATPase subunit interface; other site 251229002703 putative PBP binding loops; other site 251229002704 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 251229002705 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 251229002706 substrate binding pocket [chemical binding]; other site 251229002707 membrane-bound complex binding site; other site 251229002708 hinge residues; other site 251229002709 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 251229002710 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 251229002711 Walker A/P-loop; other site 251229002712 ATP binding site [chemical binding]; other site 251229002713 Q-loop/lid; other site 251229002714 ABC transporter signature motif; other site 251229002715 Walker B; other site 251229002716 D-loop; other site 251229002717 H-loop/switch region; other site 251229002718 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 251229002719 active site 251229002720 homotetramer interface [polypeptide binding]; other site 251229002721 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 251229002722 S-layer homology domain; Region: SLH; pfam00395 251229002723 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251229002724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 251229002725 xanthine permease; Region: pbuX; TIGR03173 251229002726 hypothetical protein; Provisional; Region: PRK06847 251229002727 hypothetical protein; Provisional; Region: PRK07236 251229002728 Uncharacterized conserved protein [Function unknown]; Region: COG3391 251229002729 C factor cell-cell signaling protein; Provisional; Region: PRK09009 251229002730 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 251229002731 NADP binding site [chemical binding]; other site 251229002732 homodimer interface [polypeptide binding]; other site 251229002733 active site 251229002734 allantoate amidohydrolase; Reviewed; Region: PRK09290 251229002735 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 251229002736 active site 251229002737 metal binding site [ion binding]; metal-binding site 251229002738 dimer interface [polypeptide binding]; other site 251229002739 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 251229002740 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 251229002741 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251229002742 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251229002743 ligand binding site [chemical binding]; other site 251229002744 flexible hinge region; other site 251229002745 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 251229002746 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 251229002747 putative active site [active] 251229002748 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229002749 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 251229002750 Walker A/P-loop; other site 251229002751 ATP binding site [chemical binding]; other site 251229002752 Q-loop/lid; other site 251229002753 ABC transporter signature motif; other site 251229002754 Walker B; other site 251229002755 D-loop; other site 251229002756 H-loop/switch region; other site 251229002757 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 251229002758 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 251229002759 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229002760 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 251229002761 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 251229002762 active site residue [active] 251229002763 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 251229002764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229002765 S-adenosylmethionine binding site [chemical binding]; other site 251229002766 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 251229002767 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 251229002768 putative active site [active] 251229002769 putative metal binding site [ion binding]; other site 251229002770 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251229002771 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251229002772 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 251229002773 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 251229002774 C-terminal domain interface [polypeptide binding]; other site 251229002775 GSH binding site (G-site) [chemical binding]; other site 251229002776 dimer interface [polypeptide binding]; other site 251229002777 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 251229002778 N-terminal domain interface [polypeptide binding]; other site 251229002779 putative dimer interface [polypeptide binding]; other site 251229002780 active site 251229002781 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 251229002782 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 251229002783 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 251229002784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251229002785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 251229002786 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 251229002787 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 251229002788 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 251229002789 active site 251229002790 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 251229002791 NADH(P)-binding; Region: NAD_binding_10; pfam13460 251229002792 NAD(P) binding site [chemical binding]; other site 251229002793 putative active site [active] 251229002794 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 251229002795 MgtE intracellular N domain; Region: MgtE_N; smart00924 251229002796 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 251229002797 Divalent cation transporter; Region: MgtE; pfam01769 251229002798 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 251229002799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229002800 dimer interface [polypeptide binding]; other site 251229002801 conserved gate region; other site 251229002802 putative PBP binding loops; other site 251229002803 ABC-ATPase subunit interface; other site 251229002804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229002805 dimer interface [polypeptide binding]; other site 251229002806 conserved gate region; other site 251229002807 putative PBP binding loops; other site 251229002808 ABC-ATPase subunit interface; other site 251229002809 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 251229002810 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 251229002811 four helix bundle protein; Region: TIGR02436 251229002812 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 251229002813 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229002814 Walker A/P-loop; other site 251229002815 ATP binding site [chemical binding]; other site 251229002816 Q-loop/lid; other site 251229002817 ABC transporter signature motif; other site 251229002818 Walker B; other site 251229002819 D-loop; other site 251229002820 H-loop/switch region; other site 251229002821 TOBE domain; Region: TOBE; pfam03459 251229002822 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 251229002823 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 251229002824 DNA-binding site [nucleotide binding]; DNA binding site 251229002825 FCD domain; Region: FCD; pfam07729 251229002826 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 251229002827 putative active site pocket [active] 251229002828 dimerization interface [polypeptide binding]; other site 251229002829 putative catalytic residue [active] 251229002830 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 251229002831 PAS fold; Region: PAS; pfam00989 251229002832 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229002833 putative active site [active] 251229002834 heme pocket [chemical binding]; other site 251229002835 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 251229002836 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 251229002837 Uncharacterized conserved protein [Function unknown]; Region: COG1565 251229002838 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 251229002839 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 251229002840 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 251229002841 putative ligand binding site [chemical binding]; other site 251229002842 putative NAD binding site [chemical binding]; other site 251229002843 catalytic site [active] 251229002844 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 251229002845 S-layer homology domain; Region: SLH; pfam00395 251229002846 S-layer homology domain; Region: SLH; pfam00395 251229002847 homoserine dehydrogenase; Provisional; Region: PRK06349 251229002848 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 251229002849 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 251229002850 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 251229002851 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 251229002852 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 251229002853 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 251229002854 dimerization interface [polypeptide binding]; other site 251229002855 FAD binding pocket [chemical binding]; other site 251229002856 FAD binding motif [chemical binding]; other site 251229002857 catalytic residues [active] 251229002858 NAD binding pocket [chemical binding]; other site 251229002859 phosphate binding motif [ion binding]; other site 251229002860 beta-alpha-beta structure motif; other site 251229002861 phosphoribulokinase; Provisional; Region: PRK07429 251229002862 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 251229002863 active site 251229002864 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 251229002865 Bifunctional nuclease; Region: DNase-RNase; pfam02577 251229002866 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 251229002867 Lumazine binding domain; Region: Lum_binding; pfam00677 251229002868 Lumazine binding domain; Region: Lum_binding; pfam00677 251229002869 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 251229002870 Peptidase family M23; Region: Peptidase_M23; pfam01551 251229002871 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 251229002872 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 251229002873 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 251229002874 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 251229002875 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 251229002876 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 251229002877 AAA ATPase domain; Region: AAA_16; pfam13191 251229002878 Walker A motif; other site 251229002879 ATP binding site [chemical binding]; other site 251229002880 Domain of unknown function (DUF309); Region: DUF309; pfam03745 251229002881 ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165 251229002882 HEAT repeats; Region: HEAT_2; pfam13646 251229002883 HEAT repeats; Region: HEAT_2; pfam13646 251229002884 FOG: CBS domain [General function prediction only]; Region: COG0517 251229002885 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 251229002886 Response regulator receiver domain; Region: Response_reg; pfam00072 251229002887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229002888 active site 251229002889 phosphorylation site [posttranslational modification] 251229002890 intermolecular recognition site; other site 251229002891 dimerization interface [polypeptide binding]; other site 251229002892 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229002893 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229002894 metal binding site [ion binding]; metal-binding site 251229002895 active site 251229002896 I-site; other site 251229002897 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 251229002898 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 251229002899 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 251229002900 hypothetical protein; Validated; Region: PRK00110 251229002901 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 251229002902 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 251229002903 cyanate hydratase; Validated; Region: PRK02866 251229002904 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 251229002905 oligomer interface [polypeptide binding]; other site 251229002906 active site 251229002907 Uncharacterized conserved protein [Function unknown]; Region: COG1543 251229002908 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 251229002909 active site 251229002910 substrate binding site [chemical binding]; other site 251229002911 catalytic site [active] 251229002912 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 251229002913 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 251229002914 Transcriptional regulator [Transcription]; Region: LysR; COG0583 251229002915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 251229002916 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 251229002917 putative dimerization interface [polypeptide binding]; other site 251229002918 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 251229002919 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 251229002920 Hexamer interface [polypeptide binding]; other site 251229002921 Hexagonal pore residue; other site 251229002922 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 251229002923 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 251229002924 Hexamer interface [polypeptide binding]; other site 251229002925 Hexagonal pore residue; other site 251229002926 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 251229002927 putative trimer interface [polypeptide binding]; other site 251229002928 putative CoA binding site [chemical binding]; other site 251229002929 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 251229002930 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 251229002931 trimer interface [polypeptide binding]; other site 251229002932 active site 251229002933 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 251229002934 putative multimerization interface [polypeptide binding]; other site 251229002935 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 251229002936 putative multimerization interface [polypeptide binding]; other site 251229002937 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 251229002938 putative multimerization interface [polypeptide binding]; other site 251229002939 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 251229002940 Hexamer/Pentamer interface [polypeptide binding]; other site 251229002941 central pore; other site 251229002942 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 251229002943 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 251229002944 Hexamer interface [polypeptide binding]; other site 251229002945 Hexagonal pore residue; other site 251229002946 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 251229002947 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 251229002948 Hexamer interface [polypeptide binding]; other site 251229002949 Hexagonal pore residue; other site 251229002950 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 251229002951 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 251229002952 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 251229002953 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 251229002954 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 251229002955 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 251229002956 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 251229002957 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 251229002958 photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056 251229002959 Helix-turn-helix domain; Region: HTH_28; pfam13518 251229002960 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251229002961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229002962 active site 251229002963 phosphorylation site [posttranslational modification] 251229002964 intermolecular recognition site; other site 251229002965 dimerization interface [polypeptide binding]; other site 251229002966 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251229002967 DNA binding residues [nucleotide binding] 251229002968 dimerization interface [polypeptide binding]; other site 251229002969 Response regulator receiver domain; Region: Response_reg; pfam00072 251229002970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229002971 active site 251229002972 phosphorylation site [posttranslational modification] 251229002973 intermolecular recognition site; other site 251229002974 dimerization interface [polypeptide binding]; other site 251229002975 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 251229002976 Histidine kinase; Region: HisKA_3; pfam07730 251229002977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229002978 ATP binding site [chemical binding]; other site 251229002979 Mg2+ binding site [ion binding]; other site 251229002980 G-X-G motif; other site 251229002981 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 251229002982 PAS domain S-box; Region: sensory_box; TIGR00229 251229002983 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229002984 putative active site [active] 251229002985 heme pocket [chemical binding]; other site 251229002986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229002987 dimer interface [polypeptide binding]; other site 251229002988 phosphorylation site [posttranslational modification] 251229002989 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 251229002990 Mg2+ binding site [ion binding]; other site 251229002991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229002992 ATP binding site [chemical binding]; other site 251229002993 G-X-G motif; other site 251229002994 Response regulator receiver domain; Region: Response_reg; pfam00072 251229002995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229002996 active site 251229002997 phosphorylation site [posttranslational modification] 251229002998 intermolecular recognition site; other site 251229002999 dimerization interface [polypeptide binding]; other site 251229003000 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229003001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229003002 active site 251229003003 phosphorylation site [posttranslational modification] 251229003004 intermolecular recognition site; other site 251229003005 dimerization interface [polypeptide binding]; other site 251229003006 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229003007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229003008 active site 251229003009 phosphorylation site [posttranslational modification] 251229003010 intermolecular recognition site; other site 251229003011 dimerization interface [polypeptide binding]; other site 251229003012 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229003013 GAF domain; Region: GAF; pfam01590 251229003014 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229003015 Phytochrome region; Region: PHY; pfam00360 251229003016 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 251229003017 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229003018 putative active site [active] 251229003019 heme pocket [chemical binding]; other site 251229003020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229003021 dimer interface [polypeptide binding]; other site 251229003022 phosphorylation site [posttranslational modification] 251229003023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229003024 ATP binding site [chemical binding]; other site 251229003025 Mg2+ binding site [ion binding]; other site 251229003026 G-X-G motif; other site 251229003027 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229003028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229003029 active site 251229003030 phosphorylation site [posttranslational modification] 251229003031 intermolecular recognition site; other site 251229003032 dimerization interface [polypeptide binding]; other site 251229003033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229003034 DNA binding site [nucleotide binding] 251229003035 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 251229003036 putative binding surface; other site 251229003037 active site 251229003038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229003039 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229003040 active site 251229003041 phosphorylation site [posttranslational modification] 251229003042 intermolecular recognition site; other site 251229003043 dimerization interface [polypeptide binding]; other site 251229003044 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229003045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229003046 active site 251229003047 phosphorylation site [posttranslational modification] 251229003048 intermolecular recognition site; other site 251229003049 dimerization interface [polypeptide binding]; other site 251229003050 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 251229003051 pheophytin binding site; other site 251229003052 chlorophyll binding site; other site 251229003053 quinone binding site; other site 251229003054 Fe binding site [ion binding]; other site 251229003055 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 251229003056 protein I interface; other site 251229003057 D2 interface; other site 251229003058 protein T interface; other site 251229003059 chlorophyll binding site; other site 251229003060 beta carotene binding site; other site 251229003061 pheophytin binding site; other site 251229003062 manganese-stabilizing polypeptide interface; other site 251229003063 CP43 interface; other site 251229003064 protein L interface; other site 251229003065 oxygen evolving complex binding site; other site 251229003066 bromide binding site; other site 251229003067 quinone binding site; other site 251229003068 Fe binding site [ion binding]; other site 251229003069 core light harvesting interface; other site 251229003070 cytochrome b559 alpha subunit interface; other site 251229003071 cytochrome c-550 interface; other site 251229003072 protein J interface; other site 251229003073 Phycobilisome protein; Region: Phycobilisome; cl08227 251229003074 Phycobilisome protein; Region: Phycobilisome; cl08227 251229003075 Phycobilisome protein; Region: Phycobilisome; cl08227 251229003076 Phycobilisome protein; Region: Phycobilisome; cl08227 251229003077 Phycobilisome protein; Region: Phycobilisome; cl08227 251229003078 Phycobilisome protein; Region: Phycobilisome; cl08227 251229003079 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251229003080 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251229003081 Phycobilisome protein; Region: Phycobilisome; cl08227 251229003082 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 251229003083 pheophytin binding site; other site 251229003084 chlorophyll binding site; other site 251229003085 quinone binding site; other site 251229003086 Fe binding site [ion binding]; other site 251229003087 Photosystem II protein; Region: PSII; cl08223 251229003088 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 251229003089 photosystem II 47 kDa protein; Region: psbB; CHL00062 251229003090 Photosystem II 10 kDa phosphoprotein; Region: PsbH; cl02951 251229003091 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 251229003092 Helix-turn-helix domain; Region: HTH_18; pfam12833 251229003093 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229003094 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 251229003095 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 251229003096 Catalytic site [active] 251229003097 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229003098 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229003099 active site 251229003100 ATP binding site [chemical binding]; other site 251229003101 substrate binding site [chemical binding]; other site 251229003102 activation loop (A-loop); other site 251229003103 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 251229003104 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 251229003105 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 251229003106 putative active site [active] 251229003107 catalytic site [active] 251229003108 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 251229003109 putative active site [active] 251229003110 catalytic site [active] 251229003111 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 251229003112 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 251229003113 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 251229003114 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 251229003115 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 251229003116 GIY-YIG motif/motif A; other site 251229003117 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 251229003118 D5 N terminal like; Region: D5_N; smart00885 251229003119 Phage associated DNA primase [General function prediction only]; Region: COG3378 251229003120 Helix-turn-helix domain; Region: HTH_17; cl17695 251229003121 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 251229003122 active site 251229003123 catalytic residues [active] 251229003124 DNA binding site [nucleotide binding] 251229003125 Int/Topo IB signature motif; other site 251229003126 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 251229003127 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251229003128 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251229003129 short chain dehydrogenase; Provisional; Region: PRK06914 251229003130 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 251229003131 NADP binding site [chemical binding]; other site 251229003132 active site 251229003133 steroid binding site; other site 251229003134 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 251229003135 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 251229003136 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 251229003137 proposed catalytic triad [active] 251229003138 active site nucleophile [active] 251229003139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229003140 S-adenosylmethionine binding site [chemical binding]; other site 251229003141 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 251229003142 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 251229003143 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 251229003144 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 251229003145 Predicted membrane protein [Function unknown]; Region: COG3431 251229003146 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 251229003147 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 251229003148 Cytochrome P450; Region: p450; pfam00067 251229003149 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 251229003150 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 251229003151 Short C-terminal domain; Region: SHOCT; pfam09851 251229003152 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 251229003153 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 251229003154 active site 251229003155 dimer interface [polypeptide binding]; other site 251229003156 catalytic nucleophile [active] 251229003157 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 251229003158 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 251229003159 Substrate binding site; other site 251229003160 Mg++ binding site; other site 251229003161 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 251229003162 active site 251229003163 substrate binding site [chemical binding]; other site 251229003164 CoA binding site [chemical binding]; other site 251229003165 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 251229003166 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 251229003167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229003168 motif II; other site 251229003169 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 251229003170 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 251229003171 Walker A/P-loop; other site 251229003172 ATP binding site [chemical binding]; other site 251229003173 Q-loop/lid; other site 251229003174 ABC transporter signature motif; other site 251229003175 Walker B; other site 251229003176 D-loop; other site 251229003177 H-loop/switch region; other site 251229003178 DevC protein; Region: devC; TIGR01185 251229003179 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251229003180 FtsX-like permease family; Region: FtsX; pfam02687 251229003181 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 251229003182 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 251229003183 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 251229003184 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229003185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251229003186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 251229003187 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 251229003188 Phosphoglycerate kinase; Region: PGK; pfam00162 251229003189 substrate binding site [chemical binding]; other site 251229003190 hinge regions; other site 251229003191 ADP binding site [chemical binding]; other site 251229003192 catalytic site [active] 251229003193 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251229003194 Ligand Binding Site [chemical binding]; other site 251229003195 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 251229003196 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 251229003197 GTP/Mg2+ binding site [chemical binding]; other site 251229003198 G4 box; other site 251229003199 G5 box; other site 251229003200 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 251229003201 G1 box; other site 251229003202 G1 box; other site 251229003203 GTP/Mg2+ binding site [chemical binding]; other site 251229003204 Switch I region; other site 251229003205 G2 box; other site 251229003206 G2 box; other site 251229003207 G3 box; other site 251229003208 G3 box; other site 251229003209 Switch II region; other site 251229003210 Switch II region; other site 251229003211 hypothetical protein; Provisional; Region: PRK13686 251229003212 Flagellin N-methylase; Region: FliB; pfam03692 251229003213 Predicted membrane protein [Function unknown]; Region: COG2119 251229003214 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 251229003215 Predicted membrane protein [Function unknown]; Region: COG2119 251229003216 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 251229003217 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 251229003218 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 251229003219 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 251229003220 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 251229003221 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 251229003222 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 251229003223 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251229003224 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 251229003225 NAD binding site [chemical binding]; other site 251229003226 homotetramer interface [polypeptide binding]; other site 251229003227 homodimer interface [polypeptide binding]; other site 251229003228 active site 251229003229 substrate binding site [chemical binding]; other site 251229003230 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229003231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229003232 S-adenosylmethionine binding site [chemical binding]; other site 251229003233 Predicted membrane protein [Function unknown]; Region: COG2246 251229003234 GtrA-like protein; Region: GtrA; pfam04138 251229003235 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 251229003236 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 251229003237 Ligand binding site; other site 251229003238 Putative Catalytic site; other site 251229003239 DXD motif; other site 251229003240 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 251229003241 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251229003242 NAD binding site [chemical binding]; other site 251229003243 homotetramer interface [polypeptide binding]; other site 251229003244 homodimer interface [polypeptide binding]; other site 251229003245 active site 251229003246 substrate binding site [chemical binding]; other site 251229003247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 251229003248 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 251229003249 Probable transposase; Region: OrfB_IS605; pfam01385 251229003250 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 251229003251 Transposase IS200 like; Region: Y1_Tnp; pfam01797 251229003252 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 251229003253 MarR family; Region: MarR_2; pfam12802 251229003254 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229003255 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229003256 structural tetrad; other site 251229003257 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229003258 structural tetrad; other site 251229003259 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229003260 structural tetrad; other site 251229003261 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229003262 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 251229003263 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 251229003264 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 251229003265 catalytic site [active] 251229003266 active site 251229003267 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 251229003268 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251229003269 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 251229003270 active site 251229003271 catalytic tetrad [active] 251229003272 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 251229003273 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 251229003274 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 251229003275 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 251229003276 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 251229003277 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 251229003278 choline dehydrogenase; Validated; Region: PRK02106 251229003279 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 251229003280 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 251229003281 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 251229003282 EthD domain; Region: EthD; pfam07110 251229003283 EthD domain; Region: EthD; pfam07110 251229003284 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 251229003285 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 251229003286 PYR/PP interface [polypeptide binding]; other site 251229003287 dimer interface [polypeptide binding]; other site 251229003288 TPP binding site [chemical binding]; other site 251229003289 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 251229003290 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 251229003291 TPP-binding site [chemical binding]; other site 251229003292 dimer interface [polypeptide binding]; other site 251229003293 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 251229003294 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 251229003295 potential catalytic triad [active] 251229003296 conserved cys residue [active] 251229003297 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 251229003298 intracellular protease, PfpI family; Region: PfpI; TIGR01382 251229003299 conserved cys residue [active] 251229003300 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 251229003301 putative active cleft [active] 251229003302 dimerization interface [polypeptide binding]; other site 251229003303 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 251229003304 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251229003305 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229003306 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 251229003307 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 251229003308 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 251229003309 deoxyhypusine synthase-like protein; Provisional; Region: PRK00770 251229003310 deoxyhypusine synthase; Region: dhys; TIGR00321 251229003311 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 251229003312 putative ADP-ribose binding site [chemical binding]; other site 251229003313 putative active site [active] 251229003314 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 251229003315 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 251229003316 putative catalytic cysteine [active] 251229003317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 251229003318 Calcium binding; Region: Calci_bind_CcbP; pfam11535 251229003319 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 251229003320 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 251229003321 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 251229003322 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 251229003323 protein I interface; other site 251229003324 D2 interface; other site 251229003325 protein T interface; other site 251229003326 chlorophyll binding site; other site 251229003327 beta carotene binding site; other site 251229003328 pheophytin binding site; other site 251229003329 manganese-stabilizing polypeptide interface; other site 251229003330 CP43 interface; other site 251229003331 protein L interface; other site 251229003332 oxygen evolving complex binding site; other site 251229003333 bromide binding site; other site 251229003334 quinone binding site; other site 251229003335 Fe binding site [ion binding]; other site 251229003336 core light harvesting interface; other site 251229003337 cytochrome b559 alpha subunit interface; other site 251229003338 cytochrome c-550 interface; other site 251229003339 protein J interface; other site 251229003340 glycogen branching enzyme; Provisional; Region: PRK05402 251229003341 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 251229003342 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 251229003343 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 251229003344 active site 251229003345 catalytic site [active] 251229003346 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 251229003347 Pleckstrin homology-like domain; Region: PH-like; cl17171 251229003348 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 251229003349 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 251229003350 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 251229003351 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 251229003352 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 251229003353 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 251229003354 oligomeric interface; other site 251229003355 putative active site [active] 251229003356 homodimer interface [polypeptide binding]; other site 251229003357 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 251229003358 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251229003359 catalytic loop [active] 251229003360 iron binding site [ion binding]; other site 251229003361 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 251229003362 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 251229003363 dimer interface [polypeptide binding]; other site 251229003364 [2Fe-2S] cluster binding site [ion binding]; other site 251229003365 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 251229003366 SLBB domain; Region: SLBB; pfam10531 251229003367 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 251229003368 bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571 251229003369 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 251229003370 putative dimer interface [polypeptide binding]; other site 251229003371 [2Fe-2S] cluster binding site [ion binding]; other site 251229003372 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 251229003373 phosphoenolpyruvate synthase; Validated; Region: PRK06464 251229003374 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 251229003375 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 251229003376 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 251229003377 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 251229003378 HSP70 interaction site [polypeptide binding]; other site 251229003379 Protein of unknown function (DUF972); Region: DUF972; pfam06156 251229003380 L,D-transpeptidase; Provisional; Region: PRK10190 251229003381 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 251229003382 Virulence-associated protein E; Region: VirE; pfam05272 251229003383 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 251229003384 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 251229003385 active site 251229003386 DNA binding site [nucleotide binding] 251229003387 Int/Topo IB signature motif; other site 251229003388 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 251229003389 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 251229003390 active site 251229003391 catalytic site [active] 251229003392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 251229003393 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 251229003394 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 251229003395 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 251229003396 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251229003397 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 251229003398 active site 251229003399 catalytic tetrad [active] 251229003400 SnoaL-like domain; Region: SnoaL_3; pfam13474 251229003401 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 251229003402 Chain length determinant protein; Region: Wzz; cl15801 251229003403 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 251229003404 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 251229003405 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 251229003406 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 251229003407 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 251229003408 inhibitor-cofactor binding pocket; inhibition site 251229003409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229003410 catalytic residue [active] 251229003411 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229003412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229003413 S-adenosylmethionine binding site [chemical binding]; other site 251229003414 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 251229003415 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 251229003416 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 251229003417 Bacterial sugar transferase; Region: Bac_transf; pfam02397 251229003418 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251229003419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229003420 NAD(P) binding site [chemical binding]; other site 251229003421 active site 251229003422 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 251229003423 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 251229003424 Mg++ binding site [ion binding]; other site 251229003425 putative catalytic motif [active] 251229003426 putative substrate binding site [chemical binding]; other site 251229003427 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 251229003428 putative ADP-binding pocket [chemical binding]; other site 251229003429 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229003430 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251229003431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229003432 NAD(P) binding site [chemical binding]; other site 251229003433 active site 251229003434 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 251229003435 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 251229003436 active site 251229003437 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229003438 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 251229003439 putative ADP-binding pocket [chemical binding]; other site 251229003440 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 251229003441 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 251229003442 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 251229003443 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 251229003444 photosystem II 44 kDa protein; Region: psbC; CHL00035 251229003445 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 251229003446 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 251229003447 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 251229003448 active site 251229003449 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 251229003450 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 251229003451 dimer interface [polypeptide binding]; other site 251229003452 active site 251229003453 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 251229003454 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 251229003455 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 251229003456 Amidase; Region: Amidase; pfam01425 251229003457 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251229003458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229003459 TPR motif; other site 251229003460 binding surface 251229003461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229003462 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 251229003463 Walker A motif; other site 251229003464 ATP binding site [chemical binding]; other site 251229003465 Walker B motif; other site 251229003466 arginine finger; other site 251229003467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229003468 binding surface 251229003469 TPR motif; other site 251229003470 TPR repeat; Region: TPR_11; pfam13414 251229003471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229003472 binding surface 251229003473 TPR motif; other site 251229003474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 251229003475 TPR motif; other site 251229003476 binding surface 251229003477 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 251229003478 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 251229003479 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 251229003480 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 251229003481 TIGR03943 family protein; Region: TIGR03943 251229003482 Predicted permeases [General function prediction only]; Region: COG0701 251229003483 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 251229003484 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 251229003485 catalytic residues [active] 251229003486 Domain of unknown function (DUF202); Region: DUF202; pfam02656 251229003487 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 251229003488 transmembrane helices; other site 251229003489 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 251229003490 TrkA-C domain; Region: TrkA_C; pfam02080 251229003491 TrkA-C domain; Region: TrkA_C; pfam02080 251229003492 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 251229003493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229003494 Coenzyme A binding pocket [chemical binding]; other site 251229003495 S-layer homology domain; Region: SLH; pfam00395 251229003496 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 251229003497 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 251229003498 dihydrodipicolinate reductase; Provisional; Region: PRK00048 251229003499 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 251229003500 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 251229003501 precorrin-8X methylmutase; Validated; Region: PRK05953 251229003502 Precorrin-8X methylmutase; Region: CbiC; pfam02570 251229003503 Repair protein; Region: Repair_PSII; pfam04536 251229003504 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 251229003505 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 251229003506 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 251229003507 trimer interface [polypeptide binding]; other site 251229003508 active site 251229003509 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 251229003510 catalytic site [active] 251229003511 PAS fold; Region: PAS; pfam00989 251229003512 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229003513 putative active site [active] 251229003514 heme pocket [chemical binding]; other site 251229003515 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251229003516 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 251229003517 putative switch regulator; other site 251229003518 non-specific DNA interactions [nucleotide binding]; other site 251229003519 DNA binding site [nucleotide binding] 251229003520 sequence specific DNA binding site [nucleotide binding]; other site 251229003521 putative cAMP binding site [chemical binding]; other site 251229003522 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 251229003523 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 251229003524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229003525 catalytic residue [active] 251229003526 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229003527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229003528 S-adenosylmethionine binding site [chemical binding]; other site 251229003529 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 251229003530 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 251229003531 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 251229003532 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 251229003533 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 251229003534 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 251229003535 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 251229003536 Cytochrome P450; Region: p450; pfam00067 251229003537 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 251229003538 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 251229003539 Probable Catalytic site; other site 251229003540 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 251229003541 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 251229003542 Hexamer interface [polypeptide binding]; other site 251229003543 Hexagonal pore residue; other site 251229003544 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 251229003545 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 251229003546 Hexamer interface [polypeptide binding]; other site 251229003547 Hexagonal pore residue; other site 251229003548 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 251229003549 active site residue [active] 251229003550 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 251229003551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229003552 ATP binding site [chemical binding]; other site 251229003553 Mg2+ binding site [ion binding]; other site 251229003554 G-X-G motif; other site 251229003555 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 251229003556 ATP binding site [chemical binding]; other site 251229003557 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 251229003558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229003559 Coenzyme A binding pocket [chemical binding]; other site 251229003560 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229003561 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229003562 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229003563 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 251229003564 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229003565 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 251229003566 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 251229003567 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 251229003568 Transcriptional regulator [Transcription]; Region: LysR; COG0583 251229003569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 251229003570 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 251229003571 dimerization interface [polypeptide binding]; other site 251229003572 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 251229003573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229003574 S-adenosylmethionine binding site [chemical binding]; other site 251229003575 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229003576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229003577 S-adenosylmethionine binding site [chemical binding]; other site 251229003578 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 251229003579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 251229003580 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 251229003581 Strictosidine synthase; Region: Str_synth; pfam03088 251229003582 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 251229003583 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 251229003584 active site 251229003585 Response regulator receiver domain; Region: Response_reg; pfam00072 251229003586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229003587 active site 251229003588 phosphorylation site [posttranslational modification] 251229003589 intermolecular recognition site; other site 251229003590 dimerization interface [polypeptide binding]; other site 251229003591 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 251229003592 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229003593 dimer interface [polypeptide binding]; other site 251229003594 phosphorylation site [posttranslational modification] 251229003595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229003596 ATP binding site [chemical binding]; other site 251229003597 Mg2+ binding site [ion binding]; other site 251229003598 G-X-G motif; other site 251229003599 RibD C-terminal domain; Region: RibD_C; cl17279 251229003600 RibD C-terminal domain; Region: RibD_C; cl17279 251229003601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 251229003602 Protein of unknown function, DUF482; Region: DUF482; pfam04339 251229003603 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 251229003604 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229003605 UDP-galactopyranose mutase; Region: GLF; pfam03275 251229003606 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 251229003607 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 251229003608 Probable Catalytic site; other site 251229003609 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 251229003610 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229003611 active site 251229003612 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229003613 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 251229003614 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 251229003615 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 251229003616 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 251229003617 Walker A/P-loop; other site 251229003618 ATP binding site [chemical binding]; other site 251229003619 Q-loop/lid; other site 251229003620 ABC transporter signature motif; other site 251229003621 Walker B; other site 251229003622 D-loop; other site 251229003623 H-loop/switch region; other site 251229003624 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 251229003625 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229003626 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229003627 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229003628 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229003629 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229003630 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 251229003631 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 251229003632 Repair protein; Region: Repair_PSII; pfam04536 251229003633 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 251229003634 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 251229003635 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 251229003636 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251229003637 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 251229003638 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229003639 molecular chaperone DnaK; Provisional; Region: PRK13410 251229003640 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 251229003641 nucleotide binding site [chemical binding]; other site 251229003642 NEF interaction site [polypeptide binding]; other site 251229003643 SBD interface [polypeptide binding]; other site 251229003644 chaperone protein DnaJ; Provisional; Region: PRK14277 251229003645 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 251229003646 HSP70 interaction site [polypeptide binding]; other site 251229003647 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 251229003648 substrate binding site [polypeptide binding]; other site 251229003649 dimer interface [polypeptide binding]; other site 251229003650 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 251229003651 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 251229003652 active site 251229003653 Protein of unknown function, DUF479; Region: DUF479; cl01203 251229003654 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 251229003655 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 251229003656 trimerization site [polypeptide binding]; other site 251229003657 active site 251229003658 Protein of function (DUF2518); Region: DUF2518; pfam10726 251229003659 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 251229003660 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 251229003661 putative active site [active] 251229003662 metal binding site [ion binding]; metal-binding site 251229003663 aspartate aminotransferase; Provisional; Region: PRK05942 251229003664 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 251229003665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229003666 homodimer interface [polypeptide binding]; other site 251229003667 catalytic residue [active] 251229003668 DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052 251229003669 Ferritin-like domain; Region: Ferritin; pfam00210 251229003670 diiron binding motif [ion binding]; other site 251229003671 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 251229003672 iron-sulfur cluster [ion binding]; other site 251229003673 [2Fe-2S] cluster binding site [ion binding]; other site 251229003674 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229003675 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229003676 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229003677 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229003678 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 251229003679 Uncharacterized conserved protein [Function unknown]; Region: COG2836 251229003680 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 251229003681 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 251229003682 Polyphenol oxidase middle domain; Region: PPO1_DWL; pfam12142 251229003683 Protein of unknown function (DUF_B2219); Region: PPO1_KFDV; pfam12143 251229003684 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251229003685 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 251229003686 active site 251229003687 catalytic tetrad [active] 251229003688 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 251229003689 diiron binding motif [ion binding]; other site 251229003690 TM2 domain; Region: TM2; cl00984 251229003691 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 251229003692 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 251229003693 MoaE interaction surface [polypeptide binding]; other site 251229003694 MoeB interaction surface [polypeptide binding]; other site 251229003695 thiocarboxylated glycine; other site 251229003696 threonine synthase; Validated; Region: PRK07591 251229003697 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 251229003698 homodimer interface [polypeptide binding]; other site 251229003699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229003700 catalytic residue [active] 251229003701 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 251229003702 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 251229003703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229003704 S-adenosylmethionine binding site [chemical binding]; other site 251229003705 Response regulator receiver domain; Region: Response_reg; pfam00072 251229003706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229003707 active site 251229003708 phosphorylation site [posttranslational modification] 251229003709 intermolecular recognition site; other site 251229003710 dimerization interface [polypeptide binding]; other site 251229003711 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229003712 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229003713 metal binding site [ion binding]; metal-binding site 251229003714 active site 251229003715 I-site; other site 251229003716 Cache domain; Region: Cache_1; pfam02743 251229003717 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229003718 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229003719 dimerization interface [polypeptide binding]; other site 251229003720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229003721 dimer interface [polypeptide binding]; other site 251229003722 phosphorylation site [posttranslational modification] 251229003723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229003724 ATP binding site [chemical binding]; other site 251229003725 Mg2+ binding site [ion binding]; other site 251229003726 G-X-G motif; other site 251229003727 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229003728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229003729 active site 251229003730 phosphorylation site [posttranslational modification] 251229003731 intermolecular recognition site; other site 251229003732 dimerization interface [polypeptide binding]; other site 251229003733 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 251229003734 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 251229003735 ABC-ATPase subunit interface; other site 251229003736 dimer interface [polypeptide binding]; other site 251229003737 putative PBP binding regions; other site 251229003738 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 251229003739 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 251229003740 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 251229003741 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 251229003742 intersubunit interface [polypeptide binding]; other site 251229003743 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 251229003744 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 251229003745 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 251229003746 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 251229003747 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229003748 putative active site [active] 251229003749 AMIN domain; Region: AMIN; pfam11741 251229003750 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251229003751 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229003752 N-terminal plug; other site 251229003753 ligand-binding site [chemical binding]; other site 251229003754 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229003755 putative active site [active] 251229003756 Helix-turn-helix domain; Region: HTH_18; pfam12833 251229003757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229003758 cytochrome c6; Provisional; Region: PRK13697 251229003759 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 251229003760 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 251229003761 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 251229003762 nucleotide binding site [chemical binding]; other site 251229003763 putative NEF/HSP70 interaction site [polypeptide binding]; other site 251229003764 SBD interface [polypeptide binding]; other site 251229003765 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 251229003766 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 251229003767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229003768 S-adenosylmethionine binding site [chemical binding]; other site 251229003769 Tic22-like family; Region: Tic22; pfam04278 251229003770 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 251229003771 active site 251229003772 catalytic residues [active] 251229003773 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 251229003774 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 251229003775 tetramer interface [polypeptide binding]; other site 251229003776 TPP-binding site [chemical binding]; other site 251229003777 heterodimer interface [polypeptide binding]; other site 251229003778 phosphorylation loop region [posttranslational modification] 251229003779 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 251229003780 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 251229003781 HSP70 interaction site [polypeptide binding]; other site 251229003782 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 251229003783 Predicted permeases [General function prediction only]; Region: COG0679 251229003784 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 251229003785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 251229003786 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 251229003787 aromatic arch; other site 251229003788 DCoH dimer interaction site [polypeptide binding]; other site 251229003789 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 251229003790 DCoH tetramer interaction site [polypeptide binding]; other site 251229003791 substrate binding site [chemical binding]; other site 251229003792 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 251229003793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229003794 putative substrate translocation pore; other site 251229003795 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 251229003796 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 251229003797 active site 251229003798 multidrug efflux protein; Reviewed; Region: PRK01766 251229003799 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 251229003800 cation binding site [ion binding]; other site 251229003801 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 251229003802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229003803 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251229003804 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229003805 Predicted permeases [General function prediction only]; Region: COG0679 251229003806 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 251229003807 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 251229003808 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 251229003809 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 251229003810 putative active site [active] 251229003811 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 251229003812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229003813 Coenzyme A binding pocket [chemical binding]; other site 251229003814 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229003815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229003816 S-adenosylmethionine binding site [chemical binding]; other site 251229003817 Transglycosylase; Region: Transgly; pfam00912 251229003818 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 251229003819 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 251229003820 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 251229003821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229003822 dimer interface [polypeptide binding]; other site 251229003823 conserved gate region; other site 251229003824 putative PBP binding loops; other site 251229003825 ABC-ATPase subunit interface; other site 251229003826 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 251229003827 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 251229003828 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 251229003829 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 251229003830 Walker A/P-loop; other site 251229003831 ATP binding site [chemical binding]; other site 251229003832 Q-loop/lid; other site 251229003833 ABC transporter signature motif; other site 251229003834 Walker B; other site 251229003835 D-loop; other site 251229003836 H-loop/switch region; other site 251229003837 TOBE domain; Region: TOBE_2; pfam08402 251229003838 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 251229003839 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 251229003840 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 251229003841 TPR repeat; Region: TPR_11; pfam13414 251229003842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229003843 binding surface 251229003844 TPR motif; other site 251229003845 Bacterial transcriptional activator domain; Region: BTAD; smart01043 251229003846 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 251229003847 Cache domain; Region: Cache_1; pfam02743 251229003848 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 251229003849 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229003850 dimerization interface [polypeptide binding]; other site 251229003851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229003852 dimer interface [polypeptide binding]; other site 251229003853 phosphorylation site [posttranslational modification] 251229003854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229003855 ATP binding site [chemical binding]; other site 251229003856 Mg2+ binding site [ion binding]; other site 251229003857 G-X-G motif; other site 251229003858 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229003859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229003860 active site 251229003861 phosphorylation site [posttranslational modification] 251229003862 intermolecular recognition site; other site 251229003863 dimerization interface [polypeptide binding]; other site 251229003864 Response regulator receiver domain; Region: Response_reg; pfam00072 251229003865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229003866 active site 251229003867 phosphorylation site [posttranslational modification] 251229003868 intermolecular recognition site; other site 251229003869 dimerization interface [polypeptide binding]; other site 251229003870 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229003871 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229003872 metal binding site [ion binding]; metal-binding site 251229003873 active site 251229003874 I-site; other site 251229003875 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 251229003876 Uncharacterized conserved protein [Function unknown]; Region: COG1479 251229003877 Protein of unknown function DUF262; Region: DUF262; pfam03235 251229003878 threonine dehydratase; Reviewed; Region: PRK09224 251229003879 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 251229003880 tetramer interface [polypeptide binding]; other site 251229003881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229003882 catalytic residue [active] 251229003883 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 251229003884 putative Ile/Val binding site [chemical binding]; other site 251229003885 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 251229003886 putative Ile/Val binding site [chemical binding]; other site 251229003887 Bacterial Ig-like domain; Region: Big_5; pfam13205 251229003888 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 251229003889 MG2 domain; Region: A2M_N; pfam01835 251229003890 Alpha-2-macroglobulin family; Region: A2M; pfam00207 251229003891 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 251229003892 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 251229003893 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 251229003894 putative ligand binding site [chemical binding]; other site 251229003895 Protein of unknown function (DUF433); Region: DUF433; cl01030 251229003896 Protein of unknown function (DUF433); Region: DUF433; cl01030 251229003897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 251229003898 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 251229003899 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 251229003900 active site 251229003901 interdomain interaction site; other site 251229003902 putative metal-binding site [ion binding]; other site 251229003903 nucleotide binding site [chemical binding]; other site 251229003904 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 251229003905 domain I; other site 251229003906 phosphate binding site [ion binding]; other site 251229003907 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 251229003908 domain II; other site 251229003909 domain III; other site 251229003910 nucleotide binding site [chemical binding]; other site 251229003911 DNA binding groove [nucleotide binding] 251229003912 catalytic site [active] 251229003913 domain IV; other site 251229003914 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 251229003915 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 251229003916 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 251229003917 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 251229003918 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 251229003919 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229003920 dimerization interface [polypeptide binding]; other site 251229003921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229003922 putative active site [active] 251229003923 heme pocket [chemical binding]; other site 251229003924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229003925 dimer interface [polypeptide binding]; other site 251229003926 phosphorylation site [posttranslational modification] 251229003927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229003928 ATP binding site [chemical binding]; other site 251229003929 Mg2+ binding site [ion binding]; other site 251229003930 G-X-G motif; other site 251229003931 Predicted membrane protein [Function unknown]; Region: COG2259 251229003932 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 251229003933 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229003934 active site 251229003935 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229003936 TPR motif; other site 251229003937 binding surface 251229003938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229003939 binding surface 251229003940 TPR motif; other site 251229003941 Peptidase family M48; Region: Peptidase_M48; cl12018 251229003942 Circadian oscillating protein COP23; Region: COP23; pfam14218 251229003943 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229003944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229003945 S-adenosylmethionine binding site [chemical binding]; other site 251229003946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229003947 Coenzyme A binding pocket [chemical binding]; other site 251229003948 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229003949 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229003950 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229003951 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229003952 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229003953 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 251229003954 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 251229003955 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 251229003956 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 251229003957 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 251229003958 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 251229003959 dimer interface [polypeptide binding]; other site 251229003960 decamer (pentamer of dimers) interface [polypeptide binding]; other site 251229003961 catalytic triad [active] 251229003962 peroxidatic and resolving cysteines [active] 251229003963 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 251229003964 Caspase domain; Region: Peptidase_C14; pfam00656 251229003965 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 251229003966 active site 251229003967 hydrophilic channel; other site 251229003968 dimerization interface [polypeptide binding]; other site 251229003969 catalytic residues [active] 251229003970 active site lid [active] 251229003971 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 251229003972 Divergent PAP2 family; Region: DUF212; pfam02681 251229003973 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 251229003974 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 251229003975 substrate binding pocket [chemical binding]; other site 251229003976 chain length determination region; other site 251229003977 substrate-Mg2+ binding site; other site 251229003978 catalytic residues [active] 251229003979 aspartate-rich region 1; other site 251229003980 active site lid residues [active] 251229003981 aspartate-rich region 2; other site 251229003982 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 251229003983 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 251229003984 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 251229003985 homodimer interface [polypeptide binding]; other site 251229003986 NADP binding site [chemical binding]; other site 251229003987 substrate binding site [chemical binding]; other site 251229003988 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 251229003989 nudix motif; other site 251229003990 EamA-like transporter family; Region: EamA; pfam00892 251229003991 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 251229003992 EamA-like transporter family; Region: EamA; pfam00892 251229003993 Predicted ATPase [General function prediction only]; Region: COG4637 251229003994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229003995 Walker A/P-loop; other site 251229003996 ATP binding site [chemical binding]; other site 251229003997 Q-loop/lid; other site 251229003998 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 251229003999 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 251229004000 MutS domain I; Region: MutS_I; pfam01624 251229004001 MutS domain II; Region: MutS_II; pfam05188 251229004002 MutS domain III; Region: MutS_III; pfam05192 251229004003 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 251229004004 Walker A/P-loop; other site 251229004005 ATP binding site [chemical binding]; other site 251229004006 Q-loop/lid; other site 251229004007 ABC transporter signature motif; other site 251229004008 Walker B; other site 251229004009 D-loop; other site 251229004010 H-loop/switch region; other site 251229004011 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251229004012 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 251229004013 active site 251229004014 metal binding site [ion binding]; metal-binding site 251229004015 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 251229004016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229004017 Coenzyme A binding pocket [chemical binding]; other site 251229004018 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 251229004019 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 251229004020 YceG-like family; Region: YceG; pfam02618 251229004021 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 251229004022 dimerization interface [polypeptide binding]; other site 251229004023 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716 251229004024 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 251229004025 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251229004026 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 251229004027 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251229004028 DNA binding residues [nucleotide binding] 251229004029 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 251229004030 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 251229004031 dimer interface [polypeptide binding]; other site 251229004032 motif 1; other site 251229004033 active site 251229004034 motif 2; other site 251229004035 motif 3; other site 251229004036 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 251229004037 anticodon binding site; other site 251229004038 gamma-glutamyl kinase; Provisional; Region: PRK05429 251229004039 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 251229004040 nucleotide binding site [chemical binding]; other site 251229004041 homotetrameric interface [polypeptide binding]; other site 251229004042 putative phosphate binding site [ion binding]; other site 251229004043 putative allosteric binding site; other site 251229004044 PUA domain; Region: PUA; pfam01472 251229004045 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 251229004046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229004047 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 251229004048 active site 251229004049 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 251229004050 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 251229004051 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 251229004052 Peptidase family M50; Region: Peptidase_M50; pfam02163 251229004053 active site 251229004054 putative substrate binding region [chemical binding]; other site 251229004055 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 251229004056 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 251229004057 active site pocket [active] 251229004058 oxyanion hole [active] 251229004059 catalytic triad [active] 251229004060 active site nucleophile [active] 251229004061 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 251229004062 substrate binding site; other site 251229004063 dimer interface; other site 251229004064 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 251229004065 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 251229004066 putative active site [active] 251229004067 Domain of unknown function (DUF1817); Region: DUF1817; pfam08847 251229004068 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 251229004069 Fasciclin domain; Region: Fasciclin; pfam02469 251229004070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 251229004071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229004072 TPR motif; other site 251229004073 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251229004074 binding surface 251229004075 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 251229004076 Surface antigen; Region: Bac_surface_Ag; pfam01103 251229004077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229004078 binding surface 251229004079 TPR motif; other site 251229004080 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 251229004081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229004082 binding surface 251229004083 TPR motif; other site 251229004084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229004085 binding surface 251229004086 TPR motif; other site 251229004087 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 251229004088 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 251229004089 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 251229004090 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 251229004091 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792 251229004092 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229004093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229004094 active site 251229004095 phosphorylation site [posttranslational modification] 251229004096 intermolecular recognition site; other site 251229004097 dimerization interface [polypeptide binding]; other site 251229004098 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229004099 DNA binding site [nucleotide binding] 251229004100 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251229004101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 251229004102 putative active site [active] 251229004103 heme pocket [chemical binding]; other site 251229004104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229004105 dimer interface [polypeptide binding]; other site 251229004106 phosphorylation site [posttranslational modification] 251229004107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229004108 ATP binding site [chemical binding]; other site 251229004109 Mg2+ binding site [ion binding]; other site 251229004110 G-X-G motif; other site 251229004111 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 251229004112 PhoU domain; Region: PhoU; pfam01895 251229004113 PhoU domain; Region: PhoU; pfam01895 251229004114 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251229004115 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 251229004116 putative switch regulator; other site 251229004117 non-specific DNA interactions [nucleotide binding]; other site 251229004118 DNA binding site [nucleotide binding] 251229004119 sequence specific DNA binding site [nucleotide binding]; other site 251229004120 putative cAMP binding site [chemical binding]; other site 251229004121 S-layer homology domain; Region: SLH; pfam00395 251229004122 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251229004123 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 251229004124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 251229004125 Uncharacterized conserved protein [Function unknown]; Region: COG1432 251229004126 LabA_like proteins; Region: LabA; cd10911 251229004127 putative metal binding site [ion binding]; other site 251229004128 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 251229004129 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 251229004130 active site 251229004131 HIGH motif; other site 251229004132 KMSKS motif; other site 251229004133 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 251229004134 anticodon binding site; other site 251229004135 tRNA binding surface [nucleotide binding]; other site 251229004136 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 251229004137 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 251229004138 putative acyl-acceptor binding pocket; other site 251229004139 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251229004140 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 251229004141 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 251229004142 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 251229004143 NAD(P) binding site [chemical binding]; other site 251229004144 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251229004145 active site 251229004146 metal binding site [ion binding]; metal-binding site 251229004147 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 251229004148 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 251229004149 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 251229004150 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229004151 Zn binding site [ion binding]; other site 251229004152 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 251229004153 Zn binding site [ion binding]; other site 251229004154 Predicted esterase [General function prediction only]; Region: COG0400 251229004155 putative hydrolase; Provisional; Region: PRK11460 251229004156 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229004157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229004158 active site 251229004159 phosphorylation site [posttranslational modification] 251229004160 intermolecular recognition site; other site 251229004161 dimerization interface [polypeptide binding]; other site 251229004162 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 251229004163 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 251229004164 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 251229004165 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 251229004166 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 251229004167 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251229004168 putative active site [active] 251229004169 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251229004170 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251229004171 ligand binding site [chemical binding]; other site 251229004172 flexible hinge region; other site 251229004173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229004174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229004175 ATP binding site [chemical binding]; other site 251229004176 Mg2+ binding site [ion binding]; other site 251229004177 G-X-G motif; other site 251229004178 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 251229004179 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 251229004180 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251229004181 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251229004182 ligand binding site [chemical binding]; other site 251229004183 flexible hinge region; other site 251229004184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229004185 ATP binding site [chemical binding]; other site 251229004186 Mg2+ binding site [ion binding]; other site 251229004187 G-X-G motif; other site 251229004188 cell division protein; Validated; Region: ftsH; CHL00176 251229004189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229004190 Walker A motif; other site 251229004191 ATP binding site [chemical binding]; other site 251229004192 Walker B motif; other site 251229004193 arginine finger; other site 251229004194 Peptidase family M41; Region: Peptidase_M41; pfam01434 251229004195 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 251229004196 classical (c) SDRs; Region: SDR_c; cd05233 251229004197 NAD(P) binding site [chemical binding]; other site 251229004198 active site 251229004199 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 251229004200 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 251229004201 dimer interface [polypeptide binding]; other site 251229004202 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 251229004203 active site 251229004204 Fe binding site [ion binding]; other site 251229004205 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 251229004206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229004207 motif II; other site 251229004208 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 251229004209 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 251229004210 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229004211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229004212 active site 251229004213 phosphorylation site [posttranslational modification] 251229004214 intermolecular recognition site; other site 251229004215 dimerization interface [polypeptide binding]; other site 251229004216 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229004217 DNA binding site [nucleotide binding] 251229004218 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 251229004219 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 251229004220 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 251229004221 alpha subunit interface [polypeptide binding]; other site 251229004222 TPP binding site [chemical binding]; other site 251229004223 heterodimer interface [polypeptide binding]; other site 251229004224 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 251229004225 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 251229004226 protein-export membrane protein SecD; Region: secD; TIGR01129 251229004227 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 251229004228 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 251229004229 Protein export membrane protein; Region: SecD_SecF; pfam02355 251229004230 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229004231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229004232 dimer interface [polypeptide binding]; other site 251229004233 phosphorylation site [posttranslational modification] 251229004234 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 251229004235 membrane protein; Provisional; Region: PRK14419 251229004236 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 251229004237 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 251229004238 Permease; Region: Permease; cl00510 251229004239 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 251229004240 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 251229004241 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 251229004242 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 251229004243 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 251229004244 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 251229004245 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 251229004246 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 251229004247 ATP-grasp domain; Region: ATP-grasp; pfam02222 251229004248 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229004249 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229004250 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229004251 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229004252 Membrane protein of unknown function; Region: DUF360; cl00850 251229004253 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 251229004254 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 251229004255 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 251229004256 classical (c) SDRs; Region: SDR_c; cd05233 251229004257 NAD(P) binding site [chemical binding]; other site 251229004258 active site 251229004259 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 251229004260 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 251229004261 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 251229004262 trimer interface [polypeptide binding]; other site 251229004263 active site 251229004264 UDP-GlcNAc binding site [chemical binding]; other site 251229004265 lipid binding site [chemical binding]; lipid-binding site 251229004266 flavoprotein, HI0933 family; Region: TIGR00275 251229004267 excinuclease ABC subunit B; Provisional; Region: PRK05298 251229004268 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251229004269 ATP binding site [chemical binding]; other site 251229004270 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251229004271 nucleotide binding region [chemical binding]; other site 251229004272 ATP-binding site [chemical binding]; other site 251229004273 Ultra-violet resistance protein B; Region: UvrB; pfam12344 251229004274 UvrB/uvrC motif; Region: UVR; pfam02151 251229004275 CsbD-like; Region: CsbD; pfam05532 251229004276 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251229004277 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251229004278 ligand binding site [chemical binding]; other site 251229004279 flexible hinge region; other site 251229004280 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 251229004281 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251229004282 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251229004283 ligand binding site [chemical binding]; other site 251229004284 flexible hinge region; other site 251229004285 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 251229004286 ChaB; Region: ChaB; pfam06150 251229004287 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 251229004288 ribosomal protein S14; Region: rps14; CHL00074 251229004289 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 251229004290 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 251229004291 minor groove reading motif; other site 251229004292 helix-hairpin-helix signature motif; other site 251229004293 substrate binding pocket [chemical binding]; other site 251229004294 active site 251229004295 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 251229004296 RIP metalloprotease RseP; Region: TIGR00054 251229004297 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 251229004298 active site 251229004299 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 251229004300 protein binding site [polypeptide binding]; other site 251229004301 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 251229004302 seryl-tRNA synthetase; Provisional; Region: PRK05431 251229004303 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 251229004304 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 251229004305 dimer interface [polypeptide binding]; other site 251229004306 active site 251229004307 motif 1; other site 251229004308 motif 2; other site 251229004309 motif 3; other site 251229004310 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 251229004311 Predicted transcriptional regulators [Transcription]; Region: COG1695 251229004312 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 251229004313 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 251229004314 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 251229004315 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229004316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229004317 dimer interface [polypeptide binding]; other site 251229004318 phosphorylation site [posttranslational modification] 251229004319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229004320 ATP binding site [chemical binding]; other site 251229004321 Mg2+ binding site [ion binding]; other site 251229004322 G-X-G motif; other site 251229004323 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 251229004324 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 251229004325 Predicted membrane protein [Function unknown]; Region: COG3431 251229004326 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 251229004327 RimM N-terminal domain; Region: RimM; pfam01782 251229004328 PRC-barrel domain; Region: PRC; pfam05239 251229004329 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 251229004330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229004331 Coenzyme A binding pocket [chemical binding]; other site 251229004332 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 251229004333 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 251229004334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229004335 homodimer interface [polypeptide binding]; other site 251229004336 catalytic residue [active] 251229004337 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 251229004338 putative homodimer interface [polypeptide binding]; other site 251229004339 putative active site pocket [active] 251229004340 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 251229004341 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 251229004342 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 251229004343 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 251229004344 active site 251229004345 catalytic site [active] 251229004346 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 251229004347 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 251229004348 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 251229004349 catalytic site [active] 251229004350 active site 251229004351 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 251229004352 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 251229004353 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 251229004354 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 251229004355 active site 251229004356 catalytic site [active] 251229004357 4-alpha-glucanotransferase; Provisional; Region: PRK14508 251229004358 trehalose synthase; Region: treS_nterm; TIGR02456 251229004359 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 251229004360 active site 251229004361 catalytic site [active] 251229004362 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 251229004363 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 251229004364 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 251229004365 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 251229004366 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 251229004367 inhibitor-cofactor binding pocket; inhibition site 251229004368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229004369 catalytic residue [active] 251229004370 Protein of unknown function (DUF561); Region: DUF561; pfam04481 251229004371 TPR repeat; Region: TPR_11; pfam13414 251229004372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229004373 binding surface 251229004374 TPR motif; other site 251229004375 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 251229004376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229004377 binding surface 251229004378 TPR motif; other site 251229004379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229004380 binding surface 251229004381 TPR motif; other site 251229004382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229004383 binding surface 251229004384 TPR motif; other site 251229004385 TPR repeat; Region: TPR_11; pfam13414 251229004386 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 251229004387 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 251229004388 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 251229004389 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 251229004390 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 251229004391 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 251229004392 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 251229004393 Catalytic site [active] 251229004394 S-layer homology domain; Region: SLH; pfam00395 251229004395 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251229004396 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 251229004397 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 251229004398 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 251229004399 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 251229004400 Protein of unknown function DUF58; Region: DUF58; pfam01882 251229004401 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 251229004402 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_8; cd06905 251229004403 putative active site [active] 251229004404 Zn binding site [ion binding]; other site 251229004405 Uncharacterized conserved protein [Function unknown]; Region: COG3379 251229004406 murein hydrolase B; Provisional; Region: PRK10760; cl17906 251229004407 GTP-binding protein YchF; Reviewed; Region: PRK09601 251229004408 YchF GTPase; Region: YchF; cd01900 251229004409 G1 box; other site 251229004410 GTP/Mg2+ binding site [chemical binding]; other site 251229004411 Switch I region; other site 251229004412 G2 box; other site 251229004413 Switch II region; other site 251229004414 G3 box; other site 251229004415 G4 box; other site 251229004416 G5 box; other site 251229004417 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 251229004418 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 251229004419 SmpB-tmRNA interface; other site 251229004420 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251229004421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229004422 active site 251229004423 phosphorylation site [posttranslational modification] 251229004424 intermolecular recognition site; other site 251229004425 dimerization interface [polypeptide binding]; other site 251229004426 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251229004427 DNA binding residues [nucleotide binding] 251229004428 dimerization interface [polypeptide binding]; other site 251229004429 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 251229004430 Low molecular weight phosphatase family; Region: LMWPc; cd00115 251229004431 active site 251229004432 hypothetical protein; Validated; Region: PRK00153 251229004433 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 251229004434 FAD binding domain; Region: FAD_binding_4; pfam01565 251229004435 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 251229004436 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 251229004437 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 251229004438 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 251229004439 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 251229004440 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 251229004441 homodecamer interface [polypeptide binding]; other site 251229004442 GTP cyclohydrolase I; Provisional; Region: PLN03044 251229004443 active site 251229004444 putative catalytic site residues [active] 251229004445 zinc binding site [ion binding]; other site 251229004446 GTP-CH-I/GFRP interaction surface; other site 251229004447 short chain dehydrogenase; Provisional; Region: PRK07454 251229004448 classical (c) SDRs; Region: SDR_c; cd05233 251229004449 NAD(P) binding site [chemical binding]; other site 251229004450 active site 251229004451 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 251229004452 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 251229004453 acyl-ACP reductase; Provisional; Region: PRK14982 251229004454 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 251229004455 NAD(P) binding pocket [chemical binding]; other site 251229004456 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 251229004457 dinuclear metal binding motif [ion binding]; other site 251229004458 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 251229004459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229004460 dimer interface [polypeptide binding]; other site 251229004461 conserved gate region; other site 251229004462 putative PBP binding loops; other site 251229004463 ABC-ATPase subunit interface; other site 251229004464 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 251229004465 MgtE intracellular N domain; Region: MgtE_N; smart00924 251229004466 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 251229004467 Divalent cation transporter; Region: MgtE; pfam01769 251229004468 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 251229004469 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 251229004470 metal binding site [ion binding]; metal-binding site 251229004471 dimer interface [polypeptide binding]; other site 251229004472 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 251229004473 Protein of unknown function (DUF751); Region: DUF751; pfam05421 251229004474 DNA adenine methylase (dam); Region: dam; TIGR00571 251229004475 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 251229004476 active site 251229004477 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 251229004478 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 251229004479 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 251229004480 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 251229004481 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 251229004482 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 251229004483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229004484 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229004485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229004486 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251229004487 Ligand Binding Site [chemical binding]; other site 251229004488 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 251229004489 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229004490 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229004491 dimer interface [polypeptide binding]; other site 251229004492 phosphorylation site [posttranslational modification] 251229004493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229004494 ATP binding site [chemical binding]; other site 251229004495 Mg2+ binding site [ion binding]; other site 251229004496 G-X-G motif; other site 251229004497 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 251229004498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229004499 Walker A motif; other site 251229004500 ATP binding site [chemical binding]; other site 251229004501 Walker B motif; other site 251229004502 arginine finger; other site 251229004503 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 251229004504 metal ion-dependent adhesion site (MIDAS); other site 251229004505 PBP superfamily domain; Region: PBP_like_2; pfam12849 251229004506 PBP superfamily domain; Region: PBP_like_2; pfam12849 251229004507 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 251229004508 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 251229004509 Moco binding site; other site 251229004510 metal coordination site [ion binding]; other site 251229004511 dimerization interface [polypeptide binding]; other site 251229004512 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251229004513 dimerization interface [polypeptide binding]; other site 251229004514 putative DNA binding site [nucleotide binding]; other site 251229004515 putative Zn2+ binding site [ion binding]; other site 251229004516 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 251229004517 putative hydrophobic ligand binding site [chemical binding]; other site 251229004518 Clp protease; Region: CLP_protease; pfam00574 251229004519 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 251229004520 oligomer interface [polypeptide binding]; other site 251229004521 active site residues [active] 251229004522 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251229004523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229004524 NAD(P) binding site [chemical binding]; other site 251229004525 active site 251229004526 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 251229004527 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229004528 Walker A/P-loop; other site 251229004529 ATP binding site [chemical binding]; other site 251229004530 Q-loop/lid; other site 251229004531 ABC transporter signature motif; other site 251229004532 Walker B; other site 251229004533 D-loop; other site 251229004534 H-loop/switch region; other site 251229004535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229004536 active site 251229004537 phosphorylation site [posttranslational modification] 251229004538 intermolecular recognition site; other site 251229004539 dimerization interface [polypeptide binding]; other site 251229004540 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 251229004541 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229004542 putative active site [active] 251229004543 heme pocket [chemical binding]; other site 251229004544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229004545 dimer interface [polypeptide binding]; other site 251229004546 phosphorylation site [posttranslational modification] 251229004547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229004548 ATP binding site [chemical binding]; other site 251229004549 Mg2+ binding site [ion binding]; other site 251229004550 G-X-G motif; other site 251229004551 Response regulator receiver domain; Region: Response_reg; pfam00072 251229004552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229004553 active site 251229004554 phosphorylation site [posttranslational modification] 251229004555 intermolecular recognition site; other site 251229004556 dimerization interface [polypeptide binding]; other site 251229004557 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229004558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229004559 active site 251229004560 phosphorylation site [posttranslational modification] 251229004561 intermolecular recognition site; other site 251229004562 dimerization interface [polypeptide binding]; other site 251229004563 Response regulator receiver domain; Region: Response_reg; pfam00072 251229004564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229004565 active site 251229004566 phosphorylation site [posttranslational modification] 251229004567 intermolecular recognition site; other site 251229004568 dimerization interface [polypeptide binding]; other site 251229004569 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229004570 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 251229004571 putative active site [active] 251229004572 heme pocket [chemical binding]; other site 251229004573 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 251229004574 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229004575 putative active site [active] 251229004576 heme pocket [chemical binding]; other site 251229004577 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229004578 putative active site [active] 251229004579 heme pocket [chemical binding]; other site 251229004580 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229004581 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229004582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229004583 dimer interface [polypeptide binding]; other site 251229004584 phosphorylation site [posttranslational modification] 251229004585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229004586 ATP binding site [chemical binding]; other site 251229004587 Mg2+ binding site [ion binding]; other site 251229004588 G-X-G motif; other site 251229004589 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 251229004590 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 251229004591 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 251229004592 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 251229004593 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 251229004594 substrate binding site [chemical binding]; other site 251229004595 catalytic Zn binding site [ion binding]; other site 251229004596 NAD binding site [chemical binding]; other site 251229004597 structural Zn binding site [ion binding]; other site 251229004598 dimer interface [polypeptide binding]; other site 251229004599 carotene isomerase; Region: carot_isom; TIGR02730 251229004600 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229004601 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 251229004602 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229004603 dimerization interface [polypeptide binding]; other site 251229004604 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229004605 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229004606 metal binding site [ion binding]; metal-binding site 251229004607 active site 251229004608 I-site; other site 251229004609 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 251229004610 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 251229004611 homotetramer interface [polypeptide binding]; other site 251229004612 FMN binding site [chemical binding]; other site 251229004613 homodimer contacts [polypeptide binding]; other site 251229004614 putative active site [active] 251229004615 putative substrate binding site [chemical binding]; other site 251229004616 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 251229004617 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 251229004618 tandem repeat interface [polypeptide binding]; other site 251229004619 oligomer interface [polypeptide binding]; other site 251229004620 active site residues [active] 251229004621 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 251229004622 tandem repeat interface [polypeptide binding]; other site 251229004623 oligomer interface [polypeptide binding]; other site 251229004624 active site residues [active] 251229004625 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 251229004626 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 251229004627 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 251229004628 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 251229004629 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 251229004630 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 251229004631 putative NAD(P) binding site [chemical binding]; other site 251229004632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 251229004633 DinB superfamily; Region: DinB_2; pfam12867 251229004634 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 251229004635 classical (c) SDRs; Region: SDR_c; cd05233 251229004636 NAD(P) binding site [chemical binding]; other site 251229004637 active site 251229004638 fumarate hydratase; Reviewed; Region: fumC; PRK00485 251229004639 Class II fumarases; Region: Fumarase_classII; cd01362 251229004640 active site 251229004641 tetramer interface [polypeptide binding]; other site 251229004642 MAPEG family; Region: MAPEG; pfam01124 251229004643 Uncharacterized conserved protein [Function unknown]; Region: COG0062 251229004644 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 251229004645 putative substrate binding site [chemical binding]; other site 251229004646 putative ATP binding site [chemical binding]; other site 251229004647 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 251229004648 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 251229004649 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 251229004650 PAS domain S-box; Region: sensory_box; TIGR00229 251229004651 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229004652 putative active site [active] 251229004653 heme pocket [chemical binding]; other site 251229004654 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229004655 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229004656 metal binding site [ion binding]; metal-binding site 251229004657 active site 251229004658 I-site; other site 251229004659 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 251229004660 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 251229004661 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229004662 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 251229004663 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229004664 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 251229004665 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 251229004666 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 251229004667 putative hydrophobic ligand binding site [chemical binding]; other site 251229004668 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 251229004669 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 251229004670 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 251229004671 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 251229004672 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 251229004673 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 251229004674 catalytic residues [active] 251229004675 Cache domain; Region: Cache_1; pfam02743 251229004676 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229004677 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229004678 dimerization interface [polypeptide binding]; other site 251229004679 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229004680 dimer interface [polypeptide binding]; other site 251229004681 phosphorylation site [posttranslational modification] 251229004682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229004683 ATP binding site [chemical binding]; other site 251229004684 Mg2+ binding site [ion binding]; other site 251229004685 G-X-G motif; other site 251229004686 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229004687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229004688 active site 251229004689 phosphorylation site [posttranslational modification] 251229004690 intermolecular recognition site; other site 251229004691 dimerization interface [polypeptide binding]; other site 251229004692 Response regulator receiver domain; Region: Response_reg; pfam00072 251229004693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229004694 active site 251229004695 phosphorylation site [posttranslational modification] 251229004696 intermolecular recognition site; other site 251229004697 dimerization interface [polypeptide binding]; other site 251229004698 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229004699 PAS fold; Region: PAS_3; pfam08447 251229004700 putative active site [active] 251229004701 heme pocket [chemical binding]; other site 251229004702 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229004703 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229004704 metal binding site [ion binding]; metal-binding site 251229004705 active site 251229004706 I-site; other site 251229004707 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 251229004708 phosphoenolpyruvate synthase; Validated; Region: PRK06464 251229004709 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 251229004710 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 251229004711 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 251229004712 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 251229004713 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 251229004714 generic binding surface II; other site 251229004715 ssDNA binding site; other site 251229004716 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251229004717 ATP binding site [chemical binding]; other site 251229004718 putative Mg++ binding site [ion binding]; other site 251229004719 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251229004720 nucleotide binding region [chemical binding]; other site 251229004721 ATP-binding site [chemical binding]; other site 251229004722 elongation factor Ts; Reviewed; Region: tsf; PRK12332 251229004723 UBA/TS-N domain; Region: UBA; pfam00627 251229004724 Elongation factor TS; Region: EF_TS; pfam00889 251229004725 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 251229004726 rRNA interaction site [nucleotide binding]; other site 251229004727 S8 interaction site; other site 251229004728 putative laminin-1 binding site; other site 251229004729 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 251229004730 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 251229004731 Probable Catalytic site; other site 251229004732 metal-binding site 251229004733 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 251229004734 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 251229004735 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 251229004736 anti sigma factor interaction site; other site 251229004737 regulatory phosphorylation site [posttranslational modification]; other site 251229004738 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 251229004739 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 251229004740 Peptidase family M23; Region: Peptidase_M23; pfam01551 251229004741 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 251229004742 magnesium chelatase subunit H; Provisional; Region: PRK12493 251229004743 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 251229004744 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 251229004745 Transposase IS200 like; Region: Y1_Tnp; cl00848 251229004746 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 251229004747 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 251229004748 HSP70 interaction site [polypeptide binding]; other site 251229004749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229004750 TPR repeat; Region: TPR_11; pfam13414 251229004751 binding surface 251229004752 TPR motif; other site 251229004753 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229004754 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229004755 structural tetrad; other site 251229004756 Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249 251229004757 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 251229004758 catalytic motif [active] 251229004759 Zn binding site [ion binding]; other site 251229004760 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 251229004761 dimerization interface [polypeptide binding]; other site 251229004762 active site 251229004763 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 251229004764 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 251229004765 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 251229004766 Walker A/P-loop; other site 251229004767 ATP binding site [chemical binding]; other site 251229004768 Q-loop/lid; other site 251229004769 ABC transporter signature motif; other site 251229004770 Walker B; other site 251229004771 D-loop; other site 251229004772 H-loop/switch region; other site 251229004773 TOBE-like domain; Region: TOBE_3; pfam12857 251229004774 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 251229004775 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 251229004776 AzlC protein; Region: AzlC; pfam03591 251229004777 PemK-like protein; Region: PemK; cl00995 251229004778 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 251229004779 Domain of unknown function (DUF202); Region: DUF202; cl09954 251229004780 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 251229004781 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 251229004782 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 251229004783 sugar binding site [chemical binding]; other site 251229004784 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 251229004785 Imelysin; Region: Peptidase_M75; cl09159 251229004786 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 251229004787 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 251229004788 Protein of unknown function (DUF512); Region: DUF512; pfam04459 251229004789 Bacitracin resistance protein BacA; Region: BacA; pfam02673 251229004790 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 251229004791 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 251229004792 HD domain; Region: HD; pfam01966 251229004793 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 251229004794 UbiA prenyltransferase family; Region: UbiA; pfam01040 251229004795 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229004796 putative active site [active] 251229004797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 251229004798 Uncharacterized conserved protein [Function unknown]; Region: COG2442 251229004799 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251229004800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229004801 active site 251229004802 phosphorylation site [posttranslational modification] 251229004803 intermolecular recognition site; other site 251229004804 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 251229004805 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 251229004806 metal binding site 2 [ion binding]; metal-binding site 251229004807 putative DNA binding helix; other site 251229004808 metal binding site 1 [ion binding]; metal-binding site 251229004809 dimer interface [polypeptide binding]; other site 251229004810 structural Zn2+ binding site [ion binding]; other site 251229004811 GTPase CgtA; Reviewed; Region: obgE; PRK12299 251229004812 GTP1/OBG; Region: GTP1_OBG; pfam01018 251229004813 Obg GTPase; Region: Obg; cd01898 251229004814 G1 box; other site 251229004815 GTP/Mg2+ binding site [chemical binding]; other site 251229004816 Switch I region; other site 251229004817 G2 box; other site 251229004818 G3 box; other site 251229004819 Switch II region; other site 251229004820 G4 box; other site 251229004821 G5 box; other site 251229004822 tellurium resistance terB-like protein; Region: terB_like; cd07177 251229004823 metal binding site [ion binding]; metal-binding site 251229004824 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 251229004825 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 251229004826 CpeS-like protein; Region: CpeS; pfam09367 251229004827 HEAT repeats; Region: HEAT_2; pfam13646 251229004828 HEAT repeats; Region: HEAT_2; pfam13646 251229004829 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 251229004830 HEAT repeats; Region: HEAT_2; pfam13646 251229004831 Photosystem II, DII subunit (also called Q(A)); Region: psbD; TIGR01152 251229004832 pheophytin binding site; other site 251229004833 chlorophyll binding site; other site 251229004834 quinone binding site; other site 251229004835 Fe binding site [ion binding]; other site 251229004836 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 251229004837 Domain of unknown function DUF20; Region: UPF0118; pfam01594 251229004838 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 251229004839 Domain of unknown function DUF20; Region: UPF0118; pfam01594 251229004840 hypothetical protein; Provisional; Region: PRK13683 251229004841 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 251229004842 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 251229004843 Walker A/P-loop; other site 251229004844 ATP binding site [chemical binding]; other site 251229004845 Q-loop/lid; other site 251229004846 ABC transporter signature motif; other site 251229004847 Walker B; other site 251229004848 D-loop; other site 251229004849 H-loop/switch region; other site 251229004850 YacP-like NYN domain; Region: NYN_YacP; cl01491 251229004851 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 251229004852 metal ion-dependent adhesion site (MIDAS); other site 251229004853 DEAD-like helicases superfamily; Region: DEXDc; smart00487 251229004854 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251229004855 ATP binding site [chemical binding]; other site 251229004856 putative Mg++ binding site [ion binding]; other site 251229004857 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251229004858 nucleotide binding region [chemical binding]; other site 251229004859 ATP-binding site [chemical binding]; other site 251229004860 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 251229004861 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 251229004862 pyrroline-5-carboxylate reductase; Region: PLN02688 251229004863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 251229004864 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 251229004865 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 251229004866 catalytic residue [active] 251229004867 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 251229004868 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 251229004869 anthranilate synthase component I-like protein; Validated; Region: PRK05940 251229004870 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 251229004871 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 251229004872 chorismate binding enzyme; Region: Chorismate_bind; cl10555 251229004873 Cobalt transport protein; Region: CbiQ; cl00463 251229004874 GTP-binding protein Der; Reviewed; Region: PRK00093 251229004875 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 251229004876 G1 box; other site 251229004877 GTP/Mg2+ binding site [chemical binding]; other site 251229004878 Switch I region; other site 251229004879 G2 box; other site 251229004880 Switch II region; other site 251229004881 G3 box; other site 251229004882 G4 box; other site 251229004883 G5 box; other site 251229004884 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 251229004885 G1 box; other site 251229004886 GTP/Mg2+ binding site [chemical binding]; other site 251229004887 Switch I region; other site 251229004888 G2 box; other site 251229004889 G3 box; other site 251229004890 Switch II region; other site 251229004891 G4 box; other site 251229004892 G5 box; other site 251229004893 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 251229004894 Galactose oxidase, central domain; Region: Kelch_3; cl02701 251229004895 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 251229004896 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 251229004897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229004898 S-adenosylmethionine binding site [chemical binding]; other site 251229004899 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 251229004900 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229004901 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 251229004902 putative catalytic residues [active] 251229004903 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 251229004904 HSP70 interaction site [polypeptide binding]; other site 251229004905 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 251229004906 substrate binding site [polypeptide binding]; other site 251229004907 dimer interface [polypeptide binding]; other site 251229004908 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 251229004909 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 251229004910 dimer interface [polypeptide binding]; other site 251229004911 anticodon binding site; other site 251229004912 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 251229004913 homodimer interface [polypeptide binding]; other site 251229004914 motif 1; other site 251229004915 active site 251229004916 motif 2; other site 251229004917 GAD domain; Region: GAD; pfam02938 251229004918 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 251229004919 active site 251229004920 motif 3; other site 251229004921 PsbP; Region: PsbP; pfam01789 251229004922 agmatinase; Region: agmatinase; TIGR01230 251229004923 Agmatinase-like family; Region: Agmatinase-like; cd09990 251229004924 active site 251229004925 oligomer interface [polypeptide binding]; other site 251229004926 Mn binding site [ion binding]; other site 251229004927 hydrogenase nickel insertion protein HypA; Region: hypA; TIGR00100 251229004928 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 251229004929 zinc-finger; Region: zf-RING_3; pfam14369 251229004930 hydrogenase accessory protein HypB; Region: hypB; TIGR00073 251229004931 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 251229004932 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 251229004933 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 251229004934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229004935 dimer interface [polypeptide binding]; other site 251229004936 conserved gate region; other site 251229004937 putative PBP binding loops; other site 251229004938 ABC-ATPase subunit interface; other site 251229004939 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 251229004940 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 251229004941 Walker A/P-loop; other site 251229004942 ATP binding site [chemical binding]; other site 251229004943 Q-loop/lid; other site 251229004944 ABC transporter signature motif; other site 251229004945 Walker B; other site 251229004946 D-loop; other site 251229004947 H-loop/switch region; other site 251229004948 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229004949 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 251229004950 active site 251229004951 metal binding site [ion binding]; metal-binding site 251229004952 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 251229004953 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 251229004954 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 251229004955 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 251229004956 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 251229004957 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229004958 N-terminal plug; other site 251229004959 ligand-binding site [chemical binding]; other site 251229004960 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 251229004961 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 251229004962 catalytic residue [active] 251229004963 putative FPP diphosphate binding site; other site 251229004964 putative FPP binding hydrophobic cleft; other site 251229004965 dimer interface [polypeptide binding]; other site 251229004966 putative IPP diphosphate binding site; other site 251229004967 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 251229004968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229004969 Coenzyme A binding pocket [chemical binding]; other site 251229004970 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 251229004971 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 251229004972 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 251229004973 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 251229004974 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 251229004975 Walker A motif; other site 251229004976 ATP binding site [chemical binding]; other site 251229004977 Walker B motif; other site 251229004978 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 251229004979 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 251229004980 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 251229004981 Walker A motif; other site 251229004982 ATP binding site [chemical binding]; other site 251229004983 Walker B motif; other site 251229004984 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 251229004985 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 251229004986 dimer interface [polypeptide binding]; other site 251229004987 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 251229004988 molecular chaperone DnaK; Provisional; Region: PRK13411 251229004989 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 251229004990 nucleotide binding site [chemical binding]; other site 251229004991 NEF interaction site [polypeptide binding]; other site 251229004992 SBD interface [polypeptide binding]; other site 251229004993 chaperone protein DnaJ; Provisional; Region: PRK14293 251229004994 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 251229004995 HSP70 interaction site [polypeptide binding]; other site 251229004996 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 251229004997 Zn binding sites [ion binding]; other site 251229004998 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 251229004999 dimer interface [polypeptide binding]; other site 251229005000 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 251229005001 CPxP motif; other site 251229005002 GTPase RsgA; Reviewed; Region: PRK12289 251229005003 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 251229005004 RNA binding site [nucleotide binding]; other site 251229005005 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 251229005006 GTPase/Zn-binding domain interface [polypeptide binding]; other site 251229005007 GTP/Mg2+ binding site [chemical binding]; other site 251229005008 G4 box; other site 251229005009 G5 box; other site 251229005010 G1 box; other site 251229005011 Switch I region; other site 251229005012 G2 box; other site 251229005013 G3 box; other site 251229005014 Switch II region; other site 251229005015 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 251229005016 GSH binding site [chemical binding]; other site 251229005017 catalytic residues [active] 251229005018 glutathione synthetase; Provisional; Region: PRK05246 251229005019 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 251229005020 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 251229005021 recombinase A; Provisional; Region: recA; PRK09354 251229005022 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 251229005023 hexamer interface [polypeptide binding]; other site 251229005024 Walker A motif; other site 251229005025 ATP binding site [chemical binding]; other site 251229005026 Walker B motif; other site 251229005027 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 251229005028 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 251229005029 generic binding surface II; other site 251229005030 generic binding surface I; other site 251229005031 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 251229005032 Exonuclease VII small subunit [DNA replication, recombination, and repair]; Region: XseB; COG1722 251229005033 glutaminase; Provisional; Region: PRK00971 251229005034 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 251229005035 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 251229005036 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 251229005037 diaminopimelate epimerase; Provisional; Region: PRK13577 251229005038 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 251229005039 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 251229005040 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 251229005041 Cysteine-rich domain; Region: CCG; pfam02754 251229005042 Cysteine-rich domain; Region: CCG; pfam02754 251229005043 acyl carrier protein; Provisional; Region: acpP; PRK00982 251229005044 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 251229005045 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 251229005046 dimer interface [polypeptide binding]; other site 251229005047 active site 251229005048 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 251229005049 transketolase; Region: PLN02790 251229005050 TPP-binding site [chemical binding]; other site 251229005051 dimer interface [polypeptide binding]; other site 251229005052 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 251229005053 PYR/PP interface [polypeptide binding]; other site 251229005054 dimer interface [polypeptide binding]; other site 251229005055 TPP binding site [chemical binding]; other site 251229005056 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 251229005057 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 251229005058 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 251229005059 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 251229005060 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 251229005061 TPP-binding site [chemical binding]; other site 251229005062 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 251229005063 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 251229005064 PYR/PP interface [polypeptide binding]; other site 251229005065 dimer interface [polypeptide binding]; other site 251229005066 TPP binding site [chemical binding]; other site 251229005067 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 251229005068 diaminopimelate epimerase; Provisional; Region: PRK13577 251229005069 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 251229005070 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 251229005071 SnoaL-like domain; Region: SnoaL_2; pfam12680 251229005072 Predicted permease [General function prediction only]; Region: COG3329 251229005073 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 251229005074 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 251229005075 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 251229005076 Response regulator receiver domain; Region: Response_reg; pfam00072 251229005077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 251229005078 active site 251229005079 phosphorylation site [posttranslational modification] 251229005080 intermolecular recognition site; other site 251229005081 dimerization interface [polypeptide binding]; other site 251229005082 PAS domain S-box; Region: sensory_box; TIGR00229 251229005083 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229005084 putative active site [active] 251229005085 heme pocket [chemical binding]; other site 251229005086 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 251229005087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229005088 dimer interface [polypeptide binding]; other site 251229005089 phosphorylation site [posttranslational modification] 251229005090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229005091 ATP binding site [chemical binding]; other site 251229005092 Mg2+ binding site [ion binding]; other site 251229005093 G-X-G motif; other site 251229005094 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229005095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229005096 active site 251229005097 phosphorylation site [posttranslational modification] 251229005098 dimerization interface [polypeptide binding]; other site 251229005099 circadian clock protein KaiC; Reviewed; Region: PRK09302 251229005100 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 251229005101 Walker A motif; other site 251229005102 ATP binding site [chemical binding]; other site 251229005103 Walker B motif; other site 251229005104 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 251229005105 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 251229005106 Walker A motif; other site 251229005107 Walker A motif; other site 251229005108 ATP binding site [chemical binding]; other site 251229005109 Walker B motif; other site 251229005110 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 251229005111 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 251229005112 P-loop, Walker A motif; other site 251229005113 Base recognition motif; other site 251229005114 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 251229005115 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 251229005116 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229005117 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229005118 structural tetrad; other site 251229005119 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 251229005120 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 251229005121 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 251229005122 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 251229005123 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 251229005124 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 251229005125 active site 251229005126 dimer interface [polypeptide binding]; other site 251229005127 motif 1; other site 251229005128 motif 2; other site 251229005129 motif 3; other site 251229005130 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 251229005131 anticodon binding site; other site 251229005132 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 251229005133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229005134 S-adenosylmethionine binding site [chemical binding]; other site 251229005135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 251229005136 Phycobilisome protein; Region: Phycobilisome; cl08227 251229005137 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 251229005138 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 251229005139 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 251229005140 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251229005141 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 251229005142 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 251229005143 nucleophilic elbow; other site 251229005144 catalytic site [active] 251229005145 catalytic triad; other site 251229005146 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 251229005147 Domain of unknown function DUF20; Region: UPF0118; pfam01594 251229005148 septum formation inhibitor; Reviewed; Region: minC; PRK00513 251229005149 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 251229005150 septum site-determining protein MinD; Region: minD_bact; TIGR01968 251229005151 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 251229005152 Switch I; other site 251229005153 Switch II; other site 251229005154 cell division topological specificity factor MinE; Provisional; Region: PRK13988 251229005155 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 251229005156 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 251229005157 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 251229005158 alpha subunit interaction interface [polypeptide binding]; other site 251229005159 Walker A motif; other site 251229005160 ATP binding site [chemical binding]; other site 251229005161 Walker B motif; other site 251229005162 inhibitor binding site; inhibition site 251229005163 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 251229005164 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 251229005165 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 251229005166 gamma subunit interface [polypeptide binding]; other site 251229005167 epsilon subunit interface [polypeptide binding]; other site 251229005168 LBP interface [polypeptide binding]; other site 251229005169 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 251229005170 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 251229005171 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 251229005172 hypothetical protein; Provisional; Region: PRK02724 251229005173 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 251229005174 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 251229005175 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 251229005176 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 251229005177 active site 251229005178 TDP-binding site; other site 251229005179 acceptor substrate-binding pocket; other site 251229005180 homodimer interface [polypeptide binding]; other site 251229005181 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 251229005182 dimanganese center [ion binding]; other site 251229005183 Cupin domain; Region: Cupin_2; pfam07883 251229005184 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 251229005185 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 251229005186 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 251229005187 Major royal jelly protein; Region: MRJP; pfam03022 251229005188 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 251229005189 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 251229005190 NAD binding site [chemical binding]; other site 251229005191 catalytic Zn binding site [ion binding]; other site 251229005192 structural Zn binding site [ion binding]; other site 251229005193 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 251229005194 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 251229005195 NAD binding site [chemical binding]; other site 251229005196 catalytic Zn binding site [ion binding]; other site 251229005197 structural Zn binding site [ion binding]; other site 251229005198 Predicted integral membrane protein [Function unknown]; Region: COG5637 251229005199 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 251229005200 putative hydrophobic ligand binding site [chemical binding]; other site 251229005201 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 251229005202 intracellular protease, PfpI family; Region: PfpI; TIGR01382 251229005203 proposed catalytic triad [active] 251229005204 conserved cys residue [active] 251229005205 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 251229005206 dinuclear metal binding motif [ion binding]; other site 251229005207 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 251229005208 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 251229005209 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 251229005210 Moco binding site; other site 251229005211 metal coordination site [ion binding]; other site 251229005212 ribosomal protein L32; Validated; Region: rpl32; CHL00152 251229005213 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 251229005214 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 251229005215 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 251229005216 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 251229005217 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 251229005218 dihydrodipicolinate synthase; Region: dapA; TIGR00674 251229005219 dimer interface [polypeptide binding]; other site 251229005220 active site 251229005221 catalytic residue [active] 251229005222 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 251229005223 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 251229005224 trigger factor; Provisional; Region: tig; PRK01490 251229005225 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 251229005226 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 251229005227 Clp protease; Region: CLP_protease; pfam00574 251229005228 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 251229005229 oligomer interface [polypeptide binding]; other site 251229005230 active site residues [active] 251229005231 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 251229005232 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 251229005233 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 251229005234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229005235 Walker A motif; other site 251229005236 ATP binding site [chemical binding]; other site 251229005237 Walker B motif; other site 251229005238 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 251229005239 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 251229005240 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 251229005241 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 251229005242 dimer interface [polypeptide binding]; other site 251229005243 FMN binding site [chemical binding]; other site 251229005244 Predicted transcriptional regulators [Transcription]; Region: COG1725 251229005245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 251229005246 DNA-binding site [nucleotide binding]; DNA binding site 251229005247 Dienelactone hydrolase family; Region: DLH; pfam01738 251229005248 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 251229005249 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 251229005250 RNA binding site [nucleotide binding]; other site 251229005251 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 251229005252 RNA binding site [nucleotide binding]; other site 251229005253 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 251229005254 RNA binding site [nucleotide binding]; other site 251229005255 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 251229005256 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 251229005257 Walker A/P-loop; other site 251229005258 ATP binding site [chemical binding]; other site 251229005259 Q-loop/lid; other site 251229005260 ABC transporter signature motif; other site 251229005261 Walker B; other site 251229005262 D-loop; other site 251229005263 H-loop/switch region; other site 251229005264 TOBE domain; Region: TOBE_2; pfam08402 251229005265 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 251229005266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229005267 dimer interface [polypeptide binding]; other site 251229005268 conserved gate region; other site 251229005269 putative PBP binding loops; other site 251229005270 ABC-ATPase subunit interface; other site 251229005271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229005272 dimer interface [polypeptide binding]; other site 251229005273 conserved gate region; other site 251229005274 putative PBP binding loops; other site 251229005275 ABC-ATPase subunit interface; other site 251229005276 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 251229005277 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 251229005278 fructuronate transporter; Provisional; Region: PRK10034; cl15264 251229005279 GntP family permease; Region: GntP_permease; pfam02447 251229005280 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229005281 putative active site [active] 251229005282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229005283 Coenzyme A binding pocket [chemical binding]; other site 251229005284 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 251229005285 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 251229005286 N- and C-terminal domain interface [polypeptide binding]; other site 251229005287 active site 251229005288 catalytic site [active] 251229005289 metal binding site [ion binding]; metal-binding site 251229005290 carbohydrate binding site [chemical binding]; other site 251229005291 ATP binding site [chemical binding]; other site 251229005292 Response regulator receiver domain; Region: Response_reg; pfam00072 251229005293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229005294 active site 251229005295 phosphorylation site [posttranslational modification] 251229005296 intermolecular recognition site; other site 251229005297 dimerization interface [polypeptide binding]; other site 251229005298 PAS domain S-box; Region: sensory_box; TIGR00229 251229005299 PAS domain S-box; Region: sensory_box; TIGR00229 251229005300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229005301 putative active site [active] 251229005302 heme pocket [chemical binding]; other site 251229005303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229005304 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 251229005305 putative active site [active] 251229005306 heme pocket [chemical binding]; other site 251229005307 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229005308 putative active site [active] 251229005309 heme pocket [chemical binding]; other site 251229005310 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229005311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229005312 dimer interface [polypeptide binding]; other site 251229005313 phosphorylation site [posttranslational modification] 251229005314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229005315 ATP binding site [chemical binding]; other site 251229005316 Mg2+ binding site [ion binding]; other site 251229005317 G-X-G motif; other site 251229005318 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229005319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229005320 active site 251229005321 phosphorylation site [posttranslational modification] 251229005322 intermolecular recognition site; other site 251229005323 dimerization interface [polypeptide binding]; other site 251229005324 S-layer homology domain; Region: SLH; pfam00395 251229005325 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251229005326 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 251229005327 Domain of unknown function (DUF814); Region: DUF814; pfam05670 251229005328 hypothetical protein; Provisional; Region: PRK04323 251229005329 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 251229005330 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 251229005331 catalytic site [active] 251229005332 G-X2-G-X-G-K; other site 251229005333 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 251229005334 Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320 251229005335 Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320 251229005336 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 251229005337 UGMP family protein; Validated; Region: PRK09604 251229005338 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 251229005339 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 251229005340 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 251229005341 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 251229005342 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 251229005343 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 251229005344 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 251229005345 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 251229005346 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 251229005347 nickel binding site [ion binding]; other site 251229005348 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 251229005349 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 251229005350 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 251229005351 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 251229005352 CHAT domain; Region: CHAT; cl17868 251229005353 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 251229005354 CHASE2 domain; Region: CHASE2; pfam05226 251229005355 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 251229005356 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 251229005357 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 251229005358 active site 251229005359 catalytic residues [active] 251229005360 DNA binding site [nucleotide binding] 251229005361 Int/Topo IB signature motif; other site 251229005362 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 251229005363 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 251229005364 Mg++ binding site [ion binding]; other site 251229005365 putative catalytic motif [active] 251229005366 substrate binding site [chemical binding]; other site 251229005367 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 251229005368 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 251229005369 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 251229005370 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 251229005371 Peptidase family M23; Region: Peptidase_M23; pfam01551 251229005372 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 251229005373 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 251229005374 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 251229005375 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 251229005376 TM-ABC transporter signature motif; other site 251229005377 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 251229005378 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 251229005379 Walker A/P-loop; other site 251229005380 ATP binding site [chemical binding]; other site 251229005381 Q-loop/lid; other site 251229005382 ABC transporter signature motif; other site 251229005383 Walker B; other site 251229005384 D-loop; other site 251229005385 H-loop/switch region; other site 251229005386 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 251229005387 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 251229005388 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 251229005389 putative ligand binding site [chemical binding]; other site 251229005390 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 251229005391 PhoH-like protein; Region: PhoH; pfam02562 251229005392 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 251229005393 KH domain; Region: KH_4; pfam13083 251229005394 G-X-X-G motif; other site 251229005395 ribosomal protein S16; Region: rps16; CHL00005 251229005396 signal recognition particle protein; Provisional; Region: PRK10867 251229005397 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 251229005398 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 251229005399 GTP binding site [chemical binding]; other site 251229005400 Signal peptide binding domain; Region: SRP_SPB; pfam02978 251229005401 Alpha amylase catalytic domain found in maltogenic amylases, cyclodextrin glycosyltransferase, and related proteins; Region: AmyAc_AmyMalt_CGTase_like; cd11320 251229005402 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 251229005403 Ca binding site [ion binding]; other site 251229005404 active site 251229005405 catalytic site [active] 251229005406 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 251229005407 starch-binding site 2 [chemical binding]; other site 251229005408 starch-binding site 1 [chemical binding]; other site 251229005409 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229005410 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 251229005411 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 251229005412 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 251229005413 AMIN domain; Region: AMIN; pfam11741 251229005414 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251229005415 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229005416 N-terminal plug; other site 251229005417 ligand-binding site [chemical binding]; other site 251229005418 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251229005419 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229005420 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 251229005421 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229005422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229005423 dimer interface [polypeptide binding]; other site 251229005424 phosphorylation site [posttranslational modification] 251229005425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229005426 ATP binding site [chemical binding]; other site 251229005427 Mg2+ binding site [ion binding]; other site 251229005428 G-X-G motif; other site 251229005429 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 251229005430 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 251229005431 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 251229005432 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 251229005433 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 251229005434 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 251229005435 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 251229005436 Active Sites [active] 251229005437 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 251229005438 four helix bundle protein; Region: TIGR02436 251229005439 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 251229005440 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 251229005441 active site 251229005442 metal binding site [ion binding]; metal-binding site 251229005443 DNA binding site [nucleotide binding] 251229005444 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 251229005445 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 251229005446 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 251229005447 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 251229005448 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 251229005449 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 251229005450 catalytic residues [active] 251229005451 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 251229005452 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 251229005453 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 251229005454 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 251229005455 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 251229005456 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 251229005457 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 251229005458 AIR carboxylase; Region: AIRC; smart01001 251229005459 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 251229005460 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 251229005461 Ligand binding site; other site 251229005462 Putative Catalytic site; other site 251229005463 DXD motif; other site 251229005464 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 251229005465 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 251229005466 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 251229005467 Response regulator receiver domain; Region: Response_reg; pfam00072 251229005468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229005469 active site 251229005470 phosphorylation site [posttranslational modification] 251229005471 intermolecular recognition site; other site 251229005472 dimerization interface [polypeptide binding]; other site 251229005473 Cache domain; Region: Cache_1; pfam02743 251229005474 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 251229005475 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251229005476 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229005477 putative active site [active] 251229005478 heme pocket [chemical binding]; other site 251229005479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229005480 dimer interface [polypeptide binding]; other site 251229005481 phosphorylation site [posttranslational modification] 251229005482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229005483 ATP binding site [chemical binding]; other site 251229005484 Mg2+ binding site [ion binding]; other site 251229005485 G-X-G motif; other site 251229005486 Response regulator receiver domain; Region: Response_reg; pfam00072 251229005487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229005488 active site 251229005489 phosphorylation site [posttranslational modification] 251229005490 intermolecular recognition site; other site 251229005491 dimerization interface [polypeptide binding]; other site 251229005492 cheY-homologous receiver domain; Region: REC; smart00448 251229005493 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 251229005494 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 251229005495 acyl-activating enzyme (AAE) consensus motif; other site 251229005496 AMP binding site [chemical binding]; other site 251229005497 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229005498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229005499 S-adenosylmethionine binding site [chemical binding]; other site 251229005500 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 251229005501 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229005502 thioester reductase domain; Region: Thioester-redct; TIGR01746 251229005503 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 251229005504 putative NAD(P) binding site [chemical binding]; other site 251229005505 active site 251229005506 putative substrate binding site [chemical binding]; other site 251229005507 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229005508 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229005509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229005510 ATP binding site [chemical binding]; other site 251229005511 Mg2+ binding site [ion binding]; other site 251229005512 G-X-G motif; other site 251229005513 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229005514 PAS fold; Region: PAS_3; pfam08447 251229005515 putative active site [active] 251229005516 heme pocket [chemical binding]; other site 251229005517 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229005518 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229005519 metal binding site [ion binding]; metal-binding site 251229005520 active site 251229005521 I-site; other site 251229005522 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 251229005523 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 251229005524 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 251229005525 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 251229005526 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 251229005527 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 251229005528 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 251229005529 AMIN domain; Region: AMIN; pfam11741 251229005530 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251229005531 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229005532 N-terminal plug; other site 251229005533 ligand-binding site [chemical binding]; other site 251229005534 AMIN domain; Region: AMIN; pfam11741 251229005535 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251229005536 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229005537 N-terminal plug; other site 251229005538 ligand-binding site [chemical binding]; other site 251229005539 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 251229005540 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 251229005541 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 251229005542 putative catalytic site [active] 251229005543 putative phosphate binding site [ion binding]; other site 251229005544 active site 251229005545 metal binding site A [ion binding]; metal-binding site 251229005546 DNA binding site [nucleotide binding] 251229005547 putative AP binding site [nucleotide binding]; other site 251229005548 putative metal binding site B [ion binding]; other site 251229005549 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 251229005550 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 251229005551 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 251229005552 acetolactate synthase; Reviewed; Region: PRK08322 251229005553 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 251229005554 PYR/PP interface [polypeptide binding]; other site 251229005555 dimer interface [polypeptide binding]; other site 251229005556 TPP binding site [chemical binding]; other site 251229005557 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 251229005558 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 251229005559 TPP-binding site [chemical binding]; other site 251229005560 dimer interface [polypeptide binding]; other site 251229005561 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 251229005562 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 251229005563 NAD(P) binding site [chemical binding]; other site 251229005564 catalytic residues [active] 251229005565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229005566 active site 251229005567 phosphorylation site [posttranslational modification] 251229005568 intermolecular recognition site; other site 251229005569 dimerization interface [polypeptide binding]; other site 251229005570 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 251229005571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229005572 active site 251229005573 phosphorylation site [posttranslational modification] 251229005574 intermolecular recognition site; other site 251229005575 dimerization interface [polypeptide binding]; other site 251229005576 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 251229005577 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 251229005578 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 251229005579 putative NAD(P) binding site [chemical binding]; other site 251229005580 catalytic Zn binding site [ion binding]; other site 251229005581 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229005582 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229005583 active site 251229005584 ATP binding site [chemical binding]; other site 251229005585 substrate binding site [chemical binding]; other site 251229005586 activation loop (A-loop); other site 251229005587 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229005588 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229005589 structural tetrad; other site 251229005590 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 251229005591 Integral membrane protein DUF92; Region: DUF92; pfam01940 251229005592 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229005593 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 251229005594 active site 251229005595 metal binding site [ion binding]; metal-binding site 251229005596 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 251229005597 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229005598 putative metal binding site [ion binding]; other site 251229005599 TPR repeat; Region: TPR_11; pfam13414 251229005600 TPR repeat; Region: TPR_11; pfam13414 251229005601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229005602 binding surface 251229005603 TPR motif; other site 251229005604 TPR repeat; Region: TPR_11; pfam13414 251229005605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229005606 TPR repeat; Region: TPR_11; pfam13414 251229005607 TPR motif; other site 251229005608 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 251229005609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 251229005610 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229005611 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229005612 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 251229005613 Ferritin-like domain; Region: Ferritin; pfam00210 251229005614 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 251229005615 dinuclear metal binding motif [ion binding]; other site 251229005616 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 251229005617 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 251229005618 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 251229005619 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 251229005620 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 251229005621 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 251229005622 Walker A/P-loop; other site 251229005623 ATP binding site [chemical binding]; other site 251229005624 Q-loop/lid; other site 251229005625 ABC transporter signature motif; other site 251229005626 Walker B; other site 251229005627 D-loop; other site 251229005628 H-loop/switch region; other site 251229005629 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 251229005630 PDGLE domain; Region: PDGLE; pfam13190 251229005631 cobalt transport protein CbiM; Validated; Region: PRK06265 251229005632 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 251229005633 Condensation domain; Region: Condensation; pfam00668 251229005634 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 251229005635 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229005636 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 251229005637 Uncharacterized conserved protein [Function unknown]; Region: COG2006 251229005638 Domain of unknown function (DUF362); Region: DUF362; pfam04015 251229005639 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 251229005640 active site 251229005641 substrate binding site [chemical binding]; other site 251229005642 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 251229005643 cosubstrate binding site; other site 251229005644 catalytic site [active] 251229005645 C-terminal subdomain of the Formyltransferase-like domain found in OzmH-like proteins; Region: FMT_C_OzmH_like; cd08700 251229005646 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 251229005647 acyl-activating enzyme (AAE) consensus motif; other site 251229005648 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 251229005649 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 251229005650 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 251229005651 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 251229005652 AMP binding site [chemical binding]; other site 251229005653 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229005654 Condensation domain; Region: Condensation; pfam00668 251229005655 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229005656 Nonribosomal peptide synthase; Region: NRPS; pfam08415 251229005657 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 251229005658 acyl-activating enzyme (AAE) consensus motif; other site 251229005659 AMP binding site [chemical binding]; other site 251229005660 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229005661 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 251229005662 putative FMN binding site [chemical binding]; other site 251229005663 NADPH bind site [chemical binding]; other site 251229005664 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 251229005665 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 251229005666 hinge; other site 251229005667 active site 251229005668 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229005669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229005670 S-adenosylmethionine binding site [chemical binding]; other site 251229005671 HEAT repeats; Region: HEAT_2; pfam13646 251229005672 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 251229005673 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 251229005674 FO synthase subunit 2; Reviewed; Region: PRK07360 251229005675 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251229005676 FeS/SAM binding site; other site 251229005677 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 251229005678 dimer interface [polypeptide binding]; other site 251229005679 catalytic triad [active] 251229005680 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 251229005681 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229005682 putative ADP-binding pocket [chemical binding]; other site 251229005683 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 251229005684 EamA-like transporter family; Region: EamA; pfam00892 251229005685 EamA-like transporter family; Region: EamA; pfam00892 251229005686 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 251229005687 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 251229005688 tandem repeat interface [polypeptide binding]; other site 251229005689 oligomer interface [polypeptide binding]; other site 251229005690 active site residues [active] 251229005691 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 251229005692 homotrimer interaction site [polypeptide binding]; other site 251229005693 active site 251229005694 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 251229005695 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 251229005696 metal binding site [ion binding]; metal-binding site 251229005697 dimer interface [polypeptide binding]; other site 251229005698 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229005699 putative active site [active] 251229005700 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 251229005701 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 251229005702 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 251229005703 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251229005704 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 251229005705 catalytic loop [active] 251229005706 iron binding site [ion binding]; other site 251229005707 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 251229005708 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 251229005709 photosystem I subunit VIII; Validated; Region: psaI; CHL00186 251229005710 photosystem II reaction center protein J; Provisional; Region: PRK02565 251229005711 photosystem II reaction center L; Provisional; Region: psbL; PRK00753 251229005712 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 251229005713 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 251229005714 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 251229005715 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 251229005716 Ycf48-like protein; Provisional; Region: PRK13684 251229005717 Rubredoxin [Energy production and conversion]; Region: COG1773 251229005718 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 251229005719 iron binding site [ion binding]; other site 251229005720 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 251229005721 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 251229005722 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 251229005723 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 251229005724 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 251229005725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229005726 Coenzyme A binding pocket [chemical binding]; other site 251229005727 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 251229005728 active site 251229005729 dinuclear metal binding site [ion binding]; other site 251229005730 dimerization interface [polypeptide binding]; other site 251229005731 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 251229005732 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 251229005733 active site 251229005734 metal binding site [ion binding]; metal-binding site 251229005735 Peptidase family M48; Region: Peptidase_M48; pfam01435 251229005736 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 251229005737 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 251229005738 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 251229005739 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 251229005740 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 251229005741 NodB motif; other site 251229005742 active site 251229005743 catalytic site [active] 251229005744 metal binding site [ion binding]; metal-binding site 251229005745 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 251229005746 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 251229005747 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251229005748 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 251229005749 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251229005750 DNA binding residues [nucleotide binding] 251229005751 putative high light inducible protein; Region: PHA02337 251229005752 light-harvesting-like protein 3; Provisional; Region: PLN00014 251229005753 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 251229005754 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 251229005755 Walker A/P-loop; other site 251229005756 ATP binding site [chemical binding]; other site 251229005757 Q-loop/lid; other site 251229005758 ABC transporter signature motif; other site 251229005759 Walker B; other site 251229005760 D-loop; other site 251229005761 H-loop/switch region; other site 251229005762 TOBE domain; Region: TOBE_2; pfam08402 251229005763 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 251229005764 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 251229005765 NAD(P) binding site [chemical binding]; other site 251229005766 catalytic residues [active] 251229005767 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 251229005768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229005769 dimer interface [polypeptide binding]; other site 251229005770 conserved gate region; other site 251229005771 putative PBP binding loops; other site 251229005772 ABC-ATPase subunit interface; other site 251229005773 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 251229005774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229005775 dimer interface [polypeptide binding]; other site 251229005776 conserved gate region; other site 251229005777 putative PBP binding loops; other site 251229005778 ABC-ATPase subunit interface; other site 251229005779 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 251229005780 thiS-thiF/thiG interaction site; other site 251229005781 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 251229005782 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 251229005783 thiamine phosphate binding site [chemical binding]; other site 251229005784 active site 251229005785 pyrophosphate binding site [ion binding]; other site 251229005786 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 251229005787 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 251229005788 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 251229005789 Malic enzyme, N-terminal domain; Region: malic; pfam00390 251229005790 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 251229005791 NAD(P) binding pocket [chemical binding]; other site 251229005792 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 251229005793 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 251229005794 Catalytic site [active] 251229005795 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 251229005796 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 251229005797 acyl-activating enzyme (AAE) consensus motif; other site 251229005798 putative AMP binding site [chemical binding]; other site 251229005799 putative active site [active] 251229005800 putative CoA binding site [chemical binding]; other site 251229005801 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 251229005802 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 251229005803 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 251229005804 E3 interaction surface; other site 251229005805 lipoyl attachment site [posttranslational modification]; other site 251229005806 e3 binding domain; Region: E3_binding; pfam02817 251229005807 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 251229005808 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 251229005809 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 251229005810 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229005811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229005812 active site 251229005813 phosphorylation site [posttranslational modification] 251229005814 intermolecular recognition site; other site 251229005815 dimerization interface [polypeptide binding]; other site 251229005816 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229005817 DNA binding site [nucleotide binding] 251229005818 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 251229005819 putative binding surface; other site 251229005820 active site 251229005821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229005822 active site 251229005823 phosphorylation site [posttranslational modification] 251229005824 dimerization interface [polypeptide binding]; other site 251229005825 Response regulator receiver domain; Region: Response_reg; pfam00072 251229005826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229005827 active site 251229005828 phosphorylation site [posttranslational modification] 251229005829 intermolecular recognition site; other site 251229005830 dimerization interface [polypeptide binding]; other site 251229005831 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229005832 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229005833 metal binding site [ion binding]; metal-binding site 251229005834 active site 251229005835 I-site; other site 251229005836 Response regulator receiver domain; Region: Response_reg; pfam00072 251229005837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229005838 active site 251229005839 phosphorylation site [posttranslational modification] 251229005840 intermolecular recognition site; other site 251229005841 dimerization interface [polypeptide binding]; other site 251229005842 Uncharacterized conserved protein [Function unknown]; Region: COG1432 251229005843 LabA_like proteins; Region: LabA; cd10911 251229005844 putative metal binding site [ion binding]; other site 251229005845 ribonuclease E; Reviewed; Region: rne; PRK10811 251229005846 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 251229005847 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 251229005848 active site 251229005849 metal binding site [ion binding]; metal-binding site 251229005850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251229005851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 251229005852 WHG domain; Region: WHG; pfam13305 251229005853 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 251229005854 Amidase; Region: Amidase; pfam01425 251229005855 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 251229005856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229005857 dimer interface [polypeptide binding]; other site 251229005858 conserved gate region; other site 251229005859 putative PBP binding loops; other site 251229005860 ABC-ATPase subunit interface; other site 251229005861 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 251229005862 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 251229005863 active site 251229005864 ATP binding site [chemical binding]; other site 251229005865 substrate binding site [chemical binding]; other site 251229005866 activation loop (A-loop); other site 251229005867 TPR repeat; Region: TPR_11; pfam13414 251229005868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229005869 binding surface 251229005870 TPR motif; other site 251229005871 TPR repeat; Region: TPR_11; pfam13414 251229005872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229005873 binding surface 251229005874 TPR motif; other site 251229005875 Protein phosphatase 2C; Region: PP2C_2; pfam13672 251229005876 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 251229005877 metal ion-dependent adhesion site (MIDAS); other site 251229005878 Response regulator receiver domain; Region: Response_reg; pfam00072 251229005879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229005880 active site 251229005881 phosphorylation site [posttranslational modification] 251229005882 intermolecular recognition site; other site 251229005883 dimerization interface [polypeptide binding]; other site 251229005884 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229005885 putative active site [active] 251229005886 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 251229005887 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 251229005888 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 251229005889 catalytic residue [active] 251229005890 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 251229005891 FeS assembly protein SufD; Region: sufD; TIGR01981 251229005892 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 251229005893 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 251229005894 Walker A/P-loop; other site 251229005895 ATP binding site [chemical binding]; other site 251229005896 Q-loop/lid; other site 251229005897 ABC transporter signature motif; other site 251229005898 Walker B; other site 251229005899 D-loop; other site 251229005900 H-loop/switch region; other site 251229005901 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 251229005902 putative ABC transporter; Region: ycf24; CHL00085 251229005903 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 251229005904 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251229005905 putative DNA binding site [nucleotide binding]; other site 251229005906 putative Zn2+ binding site [ion binding]; other site 251229005907 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 251229005908 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 251229005909 DXD motif; other site 251229005910 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 251229005911 EamA-like transporter family; Region: EamA; pfam00892 251229005912 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 251229005913 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 251229005914 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 251229005915 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229005916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229005917 Walker A/P-loop; other site 251229005918 ATP binding site [chemical binding]; other site 251229005919 Q-loop/lid; other site 251229005920 ABC transporter signature motif; other site 251229005921 Walker B; other site 251229005922 D-loop; other site 251229005923 H-loop/switch region; other site 251229005924 glutathione reductase; Validated; Region: PRK06116 251229005925 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 251229005926 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 251229005927 glutathione reductase; Validated; Region: PRK06116 251229005928 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 251229005929 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 251229005930 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 251229005931 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 251229005932 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251229005933 histidinol-phosphate aminotransferase; Provisional; Region: PRK02610 251229005934 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 251229005935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229005936 homodimer interface [polypeptide binding]; other site 251229005937 catalytic residue [active] 251229005938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229005939 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 251229005940 Coenzyme A binding pocket [chemical binding]; other site 251229005941 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 251229005942 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 251229005943 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 251229005944 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229005945 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229005946 PAS fold; Region: PAS_4; pfam08448 251229005947 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229005948 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229005949 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229005950 putative active site [active] 251229005951 PAS domain; Region: PAS_9; pfam13426 251229005952 heme pocket [chemical binding]; other site 251229005953 PAS domain; Region: PAS_8; pfam13188 251229005954 PAS domain S-box; Region: sensory_box; TIGR00229 251229005955 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229005956 GAF domain; Region: GAF; pfam01590 251229005957 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229005958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229005959 dimer interface [polypeptide binding]; other site 251229005960 phosphorylation site [posttranslational modification] 251229005961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229005962 ATP binding site [chemical binding]; other site 251229005963 Mg2+ binding site [ion binding]; other site 251229005964 G-X-G motif; other site 251229005965 Response regulator receiver domain; Region: Response_reg; pfam00072 251229005966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229005967 active site 251229005968 phosphorylation site [posttranslational modification] 251229005969 intermolecular recognition site; other site 251229005970 dimerization interface [polypeptide binding]; other site 251229005971 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229005972 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229005973 dimer interface [polypeptide binding]; other site 251229005974 phosphorylation site [posttranslational modification] 251229005975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229005976 ATP binding site [chemical binding]; other site 251229005977 Mg2+ binding site [ion binding]; other site 251229005978 G-X-G motif; other site 251229005979 XisI protein; Region: XisI; pfam08869 251229005980 XisH protein; Region: XisH; pfam08814 251229005981 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229005982 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229005983 dimer interface [polypeptide binding]; other site 251229005984 phosphorylation site [posttranslational modification] 251229005985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229005986 ATP binding site [chemical binding]; other site 251229005987 Mg2+ binding site [ion binding]; other site 251229005988 G-X-G motif; other site 251229005989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229005990 active site 251229005991 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229005992 phosphorylation site [posttranslational modification] 251229005993 intermolecular recognition site; other site 251229005994 dimerization interface [polypeptide binding]; other site 251229005995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229005996 dimer interface [polypeptide binding]; other site 251229005997 phosphorylation site [posttranslational modification] 251229005998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229005999 ATP binding site [chemical binding]; other site 251229006000 Mg2+ binding site [ion binding]; other site 251229006001 G-X-G motif; other site 251229006002 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229006003 PAS fold; Region: PAS; pfam00989 251229006004 putative active site [active] 251229006005 heme pocket [chemical binding]; other site 251229006006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229006007 Response regulator receiver domain; Region: Response_reg; pfam00072 251229006008 active site 251229006009 phosphorylation site [posttranslational modification] 251229006010 intermolecular recognition site; other site 251229006011 dimerization interface [polypeptide binding]; other site 251229006012 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900 251229006013 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 251229006014 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229006015 WD domain, G-beta repeat; Region: WD40; pfam00400 251229006016 WD domain, G-beta repeat; Region: WD40; pfam00400 251229006017 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229006018 WD domain, G-beta repeat; Region: WD40; pfam00400 251229006019 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229006020 structural tetrad; other site 251229006021 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229006022 structural tetrad; other site 251229006023 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229006024 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 251229006025 MltA specific insert domain; Region: MltA; pfam03562 251229006026 3D domain; Region: 3D; pfam06725 251229006027 apocytochrome f; Reviewed; Region: PRK02693 251229006028 cytochrome f; Region: petA; CHL00037 251229006029 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 251229006030 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 251229006031 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 251229006032 cytochrome b subunit interaction site [polypeptide binding]; other site 251229006033 [2Fe-2S] cluster binding site [ion binding]; other site 251229006034 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 251229006035 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 251229006036 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 251229006037 threonine synthase; Reviewed; Region: PRK06721 251229006038 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 251229006039 homodimer interface [polypeptide binding]; other site 251229006040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229006041 catalytic residue [active] 251229006042 Domain of unknown function DUF39; Region: DUF39; pfam01837 251229006043 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 251229006044 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 251229006045 PetM family of cytochrome b6f complex subunit 7; Region: PetM; pfam08041 251229006046 Ycf39; Provisional; Region: ycf39; CHL00194 251229006047 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 251229006048 NAD(P) binding site [chemical binding]; other site 251229006049 putative active site [active] 251229006050 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 251229006051 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 251229006052 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229006053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229006054 active site 251229006055 phosphorylation site [posttranslational modification] 251229006056 intermolecular recognition site; other site 251229006057 dimerization interface [polypeptide binding]; other site 251229006058 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229006059 DNA binding site [nucleotide binding] 251229006060 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 251229006061 RNA polymerase sigma factor; Validated; Region: PRK05949 251229006062 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 251229006063 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251229006064 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 251229006065 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251229006066 DNA binding residues [nucleotide binding] 251229006067 HAS barrel domain; Region: HAS-barrel; pfam09378 251229006068 HerA helicase [Replication, recombination, and repair]; Region: COG0433 251229006069 Domain of unknown function DUF87; Region: DUF87; pfam01935 251229006070 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 251229006071 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 251229006072 C-terminal domain interface [polypeptide binding]; other site 251229006073 GSH binding site (G-site) [chemical binding]; other site 251229006074 dimer interface [polypeptide binding]; other site 251229006075 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 251229006076 N-terminal domain interface [polypeptide binding]; other site 251229006077 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 251229006078 Fasciclin domain; Region: Fasciclin; pfam02469 251229006079 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 251229006080 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 251229006081 putative metal binding site; other site 251229006082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229006083 binding surface 251229006084 TPR motif; other site 251229006085 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251229006086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229006087 binding surface 251229006088 TPR repeat; Region: TPR_11; pfam13414 251229006089 TPR motif; other site 251229006090 TPR repeat; Region: TPR_11; pfam13414 251229006091 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 251229006092 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 251229006093 Catalytic site; other site 251229006094 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 251229006095 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 251229006096 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 251229006097 dimer interface [polypeptide binding]; other site 251229006098 motif 1; other site 251229006099 active site 251229006100 motif 2; other site 251229006101 motif 3; other site 251229006102 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 251229006103 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 251229006104 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 251229006105 active site 251229006106 Riboflavin kinase; Region: Flavokinase; pfam01687 251229006107 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 251229006108 16S/18S rRNA binding site [nucleotide binding]; other site 251229006109 S13e-L30e interaction site [polypeptide binding]; other site 251229006110 25S rRNA binding site [nucleotide binding]; other site 251229006111 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 251229006112 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 251229006113 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 251229006114 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251229006115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229006116 active site 251229006117 phosphorylation site [posttranslational modification] 251229006118 intermolecular recognition site; other site 251229006119 dimerization interface [polypeptide binding]; other site 251229006120 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251229006121 DNA binding residues [nucleotide binding] 251229006122 dimerization interface [polypeptide binding]; other site 251229006123 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 251229006124 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 251229006125 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 251229006126 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 251229006127 Clp protease ATP binding subunit; Region: clpC; CHL00095 251229006128 Clp amino terminal domain; Region: Clp_N; pfam02861 251229006129 Clp amino terminal domain; Region: Clp_N; pfam02861 251229006130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229006131 Walker A motif; other site 251229006132 ATP binding site [chemical binding]; other site 251229006133 Walker B motif; other site 251229006134 arginine finger; other site 251229006135 UvrB/uvrC motif; Region: UVR; pfam02151 251229006136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229006137 Walker A motif; other site 251229006138 ATP binding site [chemical binding]; other site 251229006139 Walker B motif; other site 251229006140 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 251229006141 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 251229006142 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251229006143 phosphopeptide binding site; other site 251229006144 PAS fold; Region: PAS_4; pfam08448 251229006145 PAS domain; Region: PAS; smart00091 251229006146 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251229006147 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229006148 dimer interface [polypeptide binding]; other site 251229006149 phosphorylation site [posttranslational modification] 251229006150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229006151 ATP binding site [chemical binding]; other site 251229006152 Mg2+ binding site [ion binding]; other site 251229006153 G-X-G motif; other site 251229006154 short chain dehydrogenase; Provisional; Region: PRK07109 251229006155 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 251229006156 putative NAD(P) binding site [chemical binding]; other site 251229006157 active site 251229006158 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 251229006159 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 251229006160 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 251229006161 putative NAD(P) binding site [chemical binding]; other site 251229006162 putative substrate binding site [chemical binding]; other site 251229006163 catalytic Zn binding site [ion binding]; other site 251229006164 structural Zn binding site [ion binding]; other site 251229006165 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 251229006166 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 251229006167 nucleotide binding site [chemical binding]; other site 251229006168 NEF interaction site [polypeptide binding]; other site 251229006169 SBD interface [polypeptide binding]; other site 251229006170 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 251229006171 Response regulator receiver domain; Region: Response_reg; pfam00072 251229006172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229006173 active site 251229006174 phosphorylation site [posttranslational modification] 251229006175 intermolecular recognition site; other site 251229006176 dimerization interface [polypeptide binding]; other site 251229006177 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 251229006178 Exoribonuclease R [Transcription]; Region: VacB; COG0557 251229006179 RNB domain; Region: RNB; pfam00773 251229006180 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 251229006181 ribosomal protein L33; Region: rpl33; CHL00104 251229006182 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 251229006183 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 251229006184 dimer interface [polypeptide binding]; other site 251229006185 putative functional site; other site 251229006186 putative MPT binding site; other site 251229006187 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251229006188 metal binding site [ion binding]; metal-binding site 251229006189 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 251229006190 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251229006191 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 251229006192 homodimer interface [polypeptide binding]; other site 251229006193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229006194 catalytic residue [active] 251229006195 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 251229006196 Domain of unknown function DUF20; Region: UPF0118; pfam01594 251229006197 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 251229006198 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 251229006199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229006200 Walker A motif; other site 251229006201 ATP binding site [chemical binding]; other site 251229006202 Walker B motif; other site 251229006203 arginine finger; other site 251229006204 Peptidase family M41; Region: Peptidase_M41; pfam01434 251229006205 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 251229006206 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 251229006207 TPR repeat; Region: TPR_11; pfam13414 251229006208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229006209 binding surface 251229006210 TPR motif; other site 251229006211 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251229006212 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 251229006213 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 251229006214 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229006215 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 251229006216 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 251229006217 putative active site [active] 251229006218 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229006219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229006220 Walker A/P-loop; other site 251229006221 ATP binding site [chemical binding]; other site 251229006222 Q-loop/lid; other site 251229006223 ABC transporter signature motif; other site 251229006224 Walker B; other site 251229006225 D-loop; other site 251229006226 H-loop/switch region; other site 251229006227 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 251229006228 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 251229006229 substrate binding site [chemical binding]; other site 251229006230 ligand binding site [chemical binding]; other site 251229006231 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 251229006232 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 251229006233 putative substrate binding site [chemical binding]; other site 251229006234 putative ATP binding site [chemical binding]; other site 251229006235 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251229006236 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251229006237 DNA binding residues [nucleotide binding] 251229006238 dimerization interface [polypeptide binding]; other site 251229006239 Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; pfam02427 251229006240 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 251229006241 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 251229006242 DNA binding site [nucleotide binding] 251229006243 catalytic residue [active] 251229006244 H2TH interface [polypeptide binding]; other site 251229006245 putative catalytic residues [active] 251229006246 turnover-facilitating residue; other site 251229006247 intercalation triad [nucleotide binding]; other site 251229006248 8OG recognition residue [nucleotide binding]; other site 251229006249 putative reading head residues; other site 251229006250 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 251229006251 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 251229006252 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 251229006253 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229006254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229006255 S-adenosylmethionine binding site [chemical binding]; other site 251229006256 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 251229006257 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251229006258 FeS/SAM binding site; other site 251229006259 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 251229006260 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 251229006261 homotrimer interaction site [polypeptide binding]; other site 251229006262 zinc binding site [ion binding]; other site 251229006263 CDP-binding sites; other site 251229006264 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 251229006265 metal ion-dependent adhesion site (MIDAS); other site 251229006266 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 251229006267 active site 251229006268 ATP binding site [chemical binding]; other site 251229006269 substrate binding site [chemical binding]; other site 251229006270 activation loop (A-loop); other site 251229006271 Response regulator receiver domain; Region: Response_reg; pfam00072 251229006272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229006273 active site 251229006274 phosphorylation site [posttranslational modification] 251229006275 intermolecular recognition site; other site 251229006276 dimerization interface [polypeptide binding]; other site 251229006277 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 251229006278 Phosphate acyltransferases; Region: PlsC; smart00563 251229006279 putative acyl-acceptor binding pocket; other site 251229006280 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 251229006281 Bacterial sugar transferase; Region: Bac_transf; pfam02397 251229006282 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229006283 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 251229006284 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 251229006285 acyl-activating enzyme (AAE) consensus motif; other site 251229006286 AMP binding site [chemical binding]; other site 251229006287 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229006288 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 251229006289 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 251229006290 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 251229006291 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 251229006292 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251229006293 active site 251229006294 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 251229006295 O-Antigen ligase; Region: Wzy_C; pfam04932 251229006296 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229006297 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 251229006298 putative ADP-binding pocket [chemical binding]; other site 251229006299 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 251229006300 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 251229006301 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 251229006302 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 251229006303 Chain length determinant protein; Region: Wzz; cl15801 251229006304 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 251229006305 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 251229006306 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 251229006307 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 251229006308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229006309 Walker A motif; other site 251229006310 ATP binding site [chemical binding]; other site 251229006311 Walker B motif; other site 251229006312 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 251229006313 Protein export membrane protein; Region: SecD_SecF; cl14618 251229006314 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251229006315 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 251229006316 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229006317 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 251229006318 NmrA-like family; Region: NmrA; pfam05368 251229006319 NADP binding site [chemical binding]; other site 251229006320 active site 251229006321 regulatory binding site [polypeptide binding]; other site 251229006322 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 251229006323 fumarylacetoacetase; Region: PLN02856 251229006324 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 251229006325 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 251229006326 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 251229006327 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 251229006328 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 251229006329 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 251229006330 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 251229006331 NADP binding site [chemical binding]; other site 251229006332 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 251229006333 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 251229006334 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229006335 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229006336 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 251229006337 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 251229006338 putative ADP-binding pocket [chemical binding]; other site 251229006339 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229006340 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 251229006341 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 251229006342 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251229006343 active site 251229006344 colanic acid exporter; Provisional; Region: PRK10459 251229006345 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 251229006346 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 251229006347 aspartate racemase; Region: asp_race; TIGR00035 251229006348 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 251229006349 Chain length determinant protein; Region: Wzz; pfam02706 251229006350 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 251229006351 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 251229006352 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 251229006353 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 251229006354 Bacterial sugar transferase; Region: Bac_transf; pfam02397 251229006355 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 251229006356 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 251229006357 Ligand binding site; other site 251229006358 metal-binding site 251229006359 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 251229006360 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 251229006361 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 251229006362 XdhC Rossmann domain; Region: XdhC_C; pfam13478 251229006363 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 251229006364 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251229006365 catalytic loop [active] 251229006366 iron binding site [ion binding]; other site 251229006367 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 251229006368 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 251229006369 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 251229006370 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 251229006371 classical (c) SDRs; Region: SDR_c; cd05233 251229006372 NAD(P) binding site [chemical binding]; other site 251229006373 active site 251229006374 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229006375 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 251229006376 active site 251229006377 SnoaL-like domain; Region: SnoaL_2; pfam12680 251229006378 SnoaL-like domain; Region: SnoaL_2; pfam12680 251229006379 hypothetical protein; Provisional; Region: PHA02977 251229006380 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 251229006381 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 251229006382 PYR/PP interface [polypeptide binding]; other site 251229006383 dimer interface [polypeptide binding]; other site 251229006384 TPP binding site [chemical binding]; other site 251229006385 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 251229006386 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 251229006387 TPP-binding site [chemical binding]; other site 251229006388 dimer interface [polypeptide binding]; other site 251229006389 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 251229006390 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 251229006391 potential catalytic triad [active] 251229006392 conserved cys residue [active] 251229006393 intracellular protease, PfpI family; Region: PfpI; TIGR01382 251229006394 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 251229006395 conserved cys residue [active] 251229006396 4-alpha-glucanotransferase; Provisional; Region: PRK14508 251229006397 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 251229006398 Strictosidine synthase; Region: Str_synth; pfam03088 251229006399 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 251229006400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229006401 NAD(P) binding site [chemical binding]; other site 251229006402 active site 251229006403 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 251229006404 amphipathic channel; other site 251229006405 Asn-Pro-Ala signature motifs; other site 251229006406 alpha-glucosidase; Provisional; Region: PRK10137 251229006407 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 251229006408 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 251229006409 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 251229006410 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 251229006411 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 251229006412 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 251229006413 active site 251229006414 catalytic site [active] 251229006415 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 251229006416 dimerization interface [polypeptide binding]; other site 251229006417 putative active cleft [active] 251229006418 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 251229006419 anti sigma factor interaction site; other site 251229006420 regulatory phosphorylation site [posttranslational modification]; other site 251229006421 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229006422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229006423 active site 251229006424 phosphorylation site [posttranslational modification] 251229006425 intermolecular recognition site; other site 251229006426 dimerization interface [polypeptide binding]; other site 251229006427 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 251229006428 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 251229006429 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 251229006430 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 251229006431 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251229006432 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251229006433 ligand binding site [chemical binding]; other site 251229006434 flexible hinge region; other site 251229006435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229006436 ATP binding site [chemical binding]; other site 251229006437 Mg2+ binding site [ion binding]; other site 251229006438 G-X-G motif; other site 251229006439 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 251229006440 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 251229006441 dimer interface [polypeptide binding]; other site 251229006442 putative PBP binding regions; other site 251229006443 ABC-ATPase subunit interface; other site 251229006444 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251229006445 dimerization interface [polypeptide binding]; other site 251229006446 putative DNA binding site [nucleotide binding]; other site 251229006447 putative Zn2+ binding site [ion binding]; other site 251229006448 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 251229006449 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 251229006450 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 251229006451 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 251229006452 putative ADP-binding pocket [chemical binding]; other site 251229006453 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229006454 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 251229006455 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 251229006456 putative active site [active] 251229006457 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229006458 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229006459 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 251229006460 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 251229006461 putative ADP-binding pocket [chemical binding]; other site 251229006462 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 251229006463 dimer interface [polypeptide binding]; other site 251229006464 active site 251229006465 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 251229006466 classical (c) SDRs; Region: SDR_c; cd05233 251229006467 NAD(P) binding site [chemical binding]; other site 251229006468 active site 251229006469 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 251229006470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229006471 active site 251229006472 motif I; other site 251229006473 motif II; other site 251229006474 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 251229006475 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 251229006476 substrate binding site [chemical binding]; other site 251229006477 ATP binding site [chemical binding]; other site 251229006478 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 251229006479 active site 251229006480 nucleotide binding site [chemical binding]; other site 251229006481 HIGH motif; other site 251229006482 KMSKS motif; other site 251229006483 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 251229006484 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 251229006485 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 251229006486 putative active site [active] 251229006487 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251229006488 active site 251229006489 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229006490 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 251229006491 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 251229006492 putative active site [active] 251229006493 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 251229006494 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 251229006495 putative active site [active] 251229006496 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229006497 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229006498 dimer interface [polypeptide binding]; other site 251229006499 phosphorylation site [posttranslational modification] 251229006500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229006501 ATP binding site [chemical binding]; other site 251229006502 Mg2+ binding site [ion binding]; other site 251229006503 G-X-G motif; other site 251229006504 Response regulator receiver domain; Region: Response_reg; pfam00072 251229006505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229006506 active site 251229006507 phosphorylation site [posttranslational modification] 251229006508 intermolecular recognition site; other site 251229006509 dimerization interface [polypeptide binding]; other site 251229006510 PAS domain S-box; Region: sensory_box; TIGR00229 251229006511 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229006512 putative active site [active] 251229006513 heme pocket [chemical binding]; other site 251229006514 PAS fold; Region: PAS_4; pfam08448 251229006515 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229006516 putative active site [active] 251229006517 heme pocket [chemical binding]; other site 251229006518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229006519 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229006520 dimer interface [polypeptide binding]; other site 251229006521 phosphorylation site [posttranslational modification] 251229006522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229006523 ATP binding site [chemical binding]; other site 251229006524 Mg2+ binding site [ion binding]; other site 251229006525 G-X-G motif; other site 251229006526 Response regulator receiver domain; Region: Response_reg; pfam00072 251229006527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229006528 active site 251229006529 phosphorylation site [posttranslational modification] 251229006530 intermolecular recognition site; other site 251229006531 dimerization interface [polypeptide binding]; other site 251229006532 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 251229006533 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 251229006534 amphipathic channel; other site 251229006535 Asn-Pro-Ala signature motifs; other site 251229006536 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 251229006537 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 251229006538 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 251229006539 B12 binding site [chemical binding]; other site 251229006540 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251229006541 FeS/SAM binding site; other site 251229006542 Predicted transcriptional regulator [Transcription]; Region: COG2345 251229006543 HTH domain; Region: HTH_11; cl17392 251229006544 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 251229006545 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 251229006546 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 251229006547 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 251229006548 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 251229006549 membrane-bound complex binding site; other site 251229006550 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 251229006551 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229006552 dimerization interface [polypeptide binding]; other site 251229006553 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 251229006554 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 251229006555 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251229006556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229006557 active site 251229006558 phosphorylation site [posttranslational modification] 251229006559 intermolecular recognition site; other site 251229006560 dimerization interface [polypeptide binding]; other site 251229006561 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251229006562 DNA binding residues [nucleotide binding] 251229006563 dimerization interface [polypeptide binding]; other site 251229006564 CHASE3 domain; Region: CHASE3; pfam05227 251229006565 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229006566 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229006567 dimerization interface [polypeptide binding]; other site 251229006568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229006569 dimer interface [polypeptide binding]; other site 251229006570 phosphorylation site [posttranslational modification] 251229006571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229006572 ATP binding site [chemical binding]; other site 251229006573 Mg2+ binding site [ion binding]; other site 251229006574 G-X-G motif; other site 251229006575 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 251229006576 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 251229006577 active site 251229006578 dimer interface [polypeptide binding]; other site 251229006579 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 251229006580 active site 251229006581 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 251229006582 catalytic core [active] 251229006583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229006584 S-adenosylmethionine binding site [chemical binding]; other site 251229006585 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 251229006586 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 251229006587 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 251229006588 substrate binding pocket [chemical binding]; other site 251229006589 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 251229006590 B12 binding site [chemical binding]; other site 251229006591 cobalt ligand [ion binding]; other site 251229006592 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 251229006593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 251229006594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229006595 S-adenosylmethionine binding site [chemical binding]; other site 251229006596 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 251229006597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229006598 dimer interface [polypeptide binding]; other site 251229006599 conserved gate region; other site 251229006600 putative PBP binding loops; other site 251229006601 ABC-ATPase subunit interface; other site 251229006602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229006603 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 251229006604 Walker A/P-loop; other site 251229006605 ATP binding site [chemical binding]; other site 251229006606 Q-loop/lid; other site 251229006607 ABC transporter signature motif; other site 251229006608 Walker B; other site 251229006609 D-loop; other site 251229006610 H-loop/switch region; other site 251229006611 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 251229006612 dimer interface [polypeptide binding]; other site 251229006613 putative tRNA-binding site [nucleotide binding]; other site 251229006614 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 251229006615 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 251229006616 DNA binding residues [nucleotide binding] 251229006617 drug binding residues [chemical binding]; other site 251229006618 homoserine kinase; Provisional; Region: PRK01212 251229006619 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 251229006620 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 251229006621 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 251229006622 DNA primase large subunit; Validated; Region: PRK02249 251229006623 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251229006624 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229006625 Walker A/P-loop; other site 251229006626 ATP binding site [chemical binding]; other site 251229006627 Q-loop/lid; other site 251229006628 ABC transporter signature motif; other site 251229006629 Walker B; other site 251229006630 D-loop; other site 251229006631 H-loop/switch region; other site 251229006632 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 251229006633 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 251229006634 P-loop; other site 251229006635 Magnesium ion binding site [ion binding]; other site 251229006636 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229006637 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229006638 active site 251229006639 ATP binding site [chemical binding]; other site 251229006640 substrate binding site [chemical binding]; other site 251229006641 activation loop (A-loop); other site 251229006642 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229006643 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229006644 structural tetrad; other site 251229006645 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 251229006646 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 251229006647 ATP-NAD kinase; Region: NAD_kinase; pfam01513 251229006648 NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015 251229006649 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 251229006650 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 251229006651 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 251229006652 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 251229006653 NADH dehydrogenase; Region: NADHdh; cl00469 251229006654 citrate synthase; Provisional; Region: PRK14036 251229006655 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 251229006656 oxalacetate binding site [chemical binding]; other site 251229006657 citrylCoA binding site [chemical binding]; other site 251229006658 coenzyme A binding site [chemical binding]; other site 251229006659 catalytic triad [active] 251229006660 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 251229006661 catalytic core [active] 251229006662 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 251229006663 DHH family; Region: DHH; pfam01368 251229006664 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 251229006665 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 251229006666 active site 251229006667 alanine racemase; Reviewed; Region: alr; PRK00053 251229006668 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 251229006669 active site 251229006670 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 251229006671 dimer interface [polypeptide binding]; other site 251229006672 substrate binding site [chemical binding]; other site 251229006673 catalytic residues [active] 251229006674 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 251229006675 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 251229006676 putative ADP-binding pocket [chemical binding]; other site 251229006677 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 251229006678 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 251229006679 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 251229006680 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 251229006681 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 251229006682 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 251229006683 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 251229006684 active site 251229006685 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 251229006686 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 251229006687 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 251229006688 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 251229006689 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 251229006690 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 251229006691 Surface antigen; Region: Bac_surface_Ag; pfam01103 251229006692 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 251229006693 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 251229006694 ATP binding site [chemical binding]; other site 251229006695 active site 251229006696 substrate binding site [chemical binding]; other site 251229006697 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 251229006698 putative active site [active] 251229006699 putative metal binding site [ion binding]; other site 251229006700 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 251229006701 metal ion-dependent adhesion site (MIDAS); other site 251229006702 Uncharacterized conserved protein [Function unknown]; Region: COG4279 251229006703 SWIM zinc finger; Region: SWIM; pfam04434 251229006704 SNF2 Helicase protein; Region: DUF3670; pfam12419 251229006705 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 251229006706 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251229006707 ATP binding site [chemical binding]; other site 251229006708 putative Mg++ binding site [ion binding]; other site 251229006709 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251229006710 nucleotide binding region [chemical binding]; other site 251229006711 ATP-binding site [chemical binding]; other site 251229006712 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 251229006713 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 251229006714 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 251229006715 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 251229006716 oligomeric interface; other site 251229006717 putative active site [active] 251229006718 homodimer interface [polypeptide binding]; other site 251229006719 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 251229006720 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 251229006721 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 251229006722 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 251229006723 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 251229006724 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 251229006725 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 251229006726 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251229006727 putative active site [active] 251229006728 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 251229006729 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229006730 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229006731 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 251229006732 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229006733 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 251229006734 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229006735 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 251229006736 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 251229006737 NADP-binding site; other site 251229006738 homotetramer interface [polypeptide binding]; other site 251229006739 substrate binding site [chemical binding]; other site 251229006740 homodimer interface [polypeptide binding]; other site 251229006741 active site 251229006742 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 251229006743 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229006744 putative active site [active] 251229006745 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 251229006746 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 251229006747 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251229006748 phosphopeptide binding site; other site 251229006749 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229006750 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229006751 active site 251229006752 ATP binding site [chemical binding]; other site 251229006753 substrate binding site [chemical binding]; other site 251229006754 activation loop (A-loop); other site 251229006755 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 251229006756 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 251229006757 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 251229006758 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 251229006759 active site 251229006760 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 251229006761 pseudouridine synthase; Region: TIGR00093 251229006762 active site 251229006763 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 251229006764 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229006765 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 251229006766 putative ADP-binding pocket [chemical binding]; other site 251229006767 Chain length determinant protein; Region: Wzz; pfam02706 251229006768 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 251229006769 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 251229006770 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229006771 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229006772 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 251229006773 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 251229006774 putative binding surface; other site 251229006775 active site 251229006776 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 251229006777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229006778 ATP binding site [chemical binding]; other site 251229006779 Mg2+ binding site [ion binding]; other site 251229006780 G-X-G motif; other site 251229006781 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 251229006782 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229006783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229006784 active site 251229006785 phosphorylation site [posttranslational modification] 251229006786 intermolecular recognition site; other site 251229006787 dimerization interface [polypeptide binding]; other site 251229006788 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229006789 dimerization interface [polypeptide binding]; other site 251229006790 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229006791 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229006792 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 251229006793 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 251229006794 dimer interface [polypeptide binding]; other site 251229006795 putative CheW interface [polypeptide binding]; other site 251229006796 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 251229006797 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 251229006798 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 251229006799 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 251229006800 hydrolase, alpha/beta fold family protein; Region: PLN02824 251229006801 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 251229006802 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 251229006803 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 251229006804 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 251229006805 shikimate binding site; other site 251229006806 NAD(P) binding site [chemical binding]; other site 251229006807 AMIN domain; Region: AMIN; pfam11741 251229006808 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 251229006809 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229006810 N-terminal plug; other site 251229006811 ligand-binding site [chemical binding]; other site 251229006812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229006813 NADH(P)-binding; Region: NAD_binding_10; pfam13460 251229006814 NAD(P) binding site [chemical binding]; other site 251229006815 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 251229006816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229006817 NADH(P)-binding; Region: NAD_binding_10; pfam13460 251229006818 active site 251229006819 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 251229006820 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251229006821 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 251229006822 putative NAD(P) binding site [chemical binding]; other site 251229006823 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251229006824 Uncharacterized conserved protein [Function unknown]; Region: COG2928 251229006825 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 251229006826 putative RNA binding site [nucleotide binding]; other site 251229006827 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 251229006828 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 251229006829 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 251229006830 P loop; other site 251229006831 GTP binding site [chemical binding]; other site 251229006832 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229006833 GAF domain; Region: GAF; cl17456 251229006834 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 251229006835 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 251229006836 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 251229006837 nudix motif; other site 251229006838 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 251229006839 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 251229006840 putative valine binding site [chemical binding]; other site 251229006841 dimer interface [polypeptide binding]; other site 251229006842 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 251229006843 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 251229006844 hydrolase, alpha/beta fold family protein; Region: PLN02824 251229006845 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 251229006846 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 251229006847 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 251229006848 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 251229006849 EamA-like transporter family; Region: EamA; pfam00892 251229006850 EamA-like transporter family; Region: EamA; pfam00892 251229006851 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 251229006852 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 251229006853 putative NAD(P) binding site [chemical binding]; other site 251229006854 putative lipid kinase; Reviewed; Region: PRK00861 251229006855 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 251229006856 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 251229006857 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 251229006858 protein-splicing catalytic site; other site 251229006859 thioester formation/cholesterol transfer; other site 251229006860 Pretoxin HINT domain; Region: PT-HINT; pfam07591 251229006861 Tim44-like domain; Region: Tim44; cl09208 251229006862 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 251229006863 Protein of unknown function DUF104; Region: DUF104; pfam01954 251229006864 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 251229006865 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 251229006866 substrate binding site [chemical binding]; other site 251229006867 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 251229006868 substrate binding site [chemical binding]; other site 251229006869 ligand binding site [chemical binding]; other site 251229006870 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251229006871 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 251229006872 catalytic loop [active] 251229006873 iron binding site [ion binding]; other site 251229006874 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 251229006875 CAAX protease self-immunity; Region: Abi; pfam02517 251229006876 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 251229006877 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 251229006878 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229006879 active site 251229006880 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 251229006881 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 251229006882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229006883 S-adenosylmethionine binding site [chemical binding]; other site 251229006884 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 251229006885 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 251229006886 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 251229006887 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229006888 active site 251229006889 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251229006890 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229006891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229006892 Walker A/P-loop; other site 251229006893 ATP binding site [chemical binding]; other site 251229006894 Q-loop/lid; other site 251229006895 ABC transporter signature motif; other site 251229006896 Walker B; other site 251229006897 D-loop; other site 251229006898 H-loop/switch region; other site 251229006899 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 251229006900 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 251229006901 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251229006902 active site 251229006903 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251229006904 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 251229006905 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229006906 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251229006907 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 251229006908 FtsX-like permease family; Region: FtsX; pfam02687 251229006909 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 251229006910 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229006911 Coenzyme A binding pocket [chemical binding]; other site 251229006912 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251229006913 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 251229006914 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; pfam01036 251229006915 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 251229006916 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 251229006917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229006918 dimer interface [polypeptide binding]; other site 251229006919 conserved gate region; other site 251229006920 putative PBP binding loops; other site 251229006921 ABC-ATPase subunit interface; other site 251229006922 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 251229006923 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 251229006924 active site 251229006925 substrate binding site [chemical binding]; other site 251229006926 cosubstrate binding site; other site 251229006927 catalytic site [active] 251229006928 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 251229006929 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 251229006930 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251229006931 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 251229006932 NAD binding site [chemical binding]; other site 251229006933 homotetramer interface [polypeptide binding]; other site 251229006934 homodimer interface [polypeptide binding]; other site 251229006935 active site 251229006936 substrate binding site [chemical binding]; other site 251229006937 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 251229006938 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 251229006939 Chain length determinant protein; Region: Wzz; pfam02706 251229006940 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 251229006941 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 251229006942 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 251229006943 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 251229006944 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 251229006945 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 251229006946 Walker A/P-loop; other site 251229006947 ATP binding site [chemical binding]; other site 251229006948 Q-loop/lid; other site 251229006949 ABC transporter signature motif; other site 251229006950 Walker B; other site 251229006951 D-loop; other site 251229006952 H-loop/switch region; other site 251229006953 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 251229006954 putative carbohydrate binding site [chemical binding]; other site 251229006955 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 251229006956 hypothetical protein; Validated; Region: PRK07080 251229006957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229006958 S-adenosylmethionine binding site [chemical binding]; other site 251229006959 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251229006960 active site 251229006961 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229006962 Methyltransferase domain; Region: Methyltransf_11; pfam08241 251229006963 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 251229006964 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 251229006965 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 251229006966 putative active site [active] 251229006967 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251229006968 active site 251229006969 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229006970 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229006971 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229006972 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229006973 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 251229006974 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 251229006975 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 251229006976 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251229006977 active site 251229006978 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 251229006979 O-Antigen ligase; Region: Wzy_C; pfam04932 251229006980 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229006981 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 251229006982 putative ADP-binding pocket [chemical binding]; other site 251229006983 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229006984 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229006985 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 251229006986 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 251229006987 hypothetical protein; Validated; Region: PRK07413 251229006988 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 251229006989 Walker A motif; other site 251229006990 homodimer interface [polypeptide binding]; other site 251229006991 ATP binding site [chemical binding]; other site 251229006992 hydroxycobalamin binding site [chemical binding]; other site 251229006993 Walker B motif; other site 251229006994 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 251229006995 Walker A motif; other site 251229006996 homodimer interface [polypeptide binding]; other site 251229006997 ATP binding site [chemical binding]; other site 251229006998 hydroxycobalamin binding site [chemical binding]; other site 251229006999 Walker B motif; other site 251229007000 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 251229007001 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229007002 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 251229007003 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 251229007004 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 251229007005 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 251229007006 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 251229007007 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 251229007008 Drosophila melanogaster CG11883 and related proteins, N-terminal metallophosphatase domain; Region: MPP_CG11883_N; cd07406 251229007009 putative active site [active] 251229007010 putative metal binding site [ion binding]; other site 251229007011 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 251229007012 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 251229007013 active site residue [active] 251229007014 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 251229007015 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251229007016 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 251229007017 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251229007018 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 251229007019 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 251229007020 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 251229007021 Phytochelatin synthase; Region: Phytochelatin; pfam05023 251229007022 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 251229007023 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251229007024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229007025 binding surface 251229007026 TPR motif; other site 251229007027 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251229007028 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 251229007029 active site 251229007030 catalytic triad [active] 251229007031 oxyanion hole [active] 251229007032 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 251229007033 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 251229007034 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 251229007035 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229007036 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229007037 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229007038 dimer interface [polypeptide binding]; other site 251229007039 phosphorylation site [posttranslational modification] 251229007040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229007041 ATP binding site [chemical binding]; other site 251229007042 G-X-G motif; other site 251229007043 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229007044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229007045 active site 251229007046 phosphorylation site [posttranslational modification] 251229007047 intermolecular recognition site; other site 251229007048 dimerization interface [polypeptide binding]; other site 251229007049 Response regulator receiver domain; Region: Response_reg; pfam00072 251229007050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229007051 active site 251229007052 phosphorylation site [posttranslational modification] 251229007053 intermolecular recognition site; other site 251229007054 dimerization interface [polypeptide binding]; other site 251229007055 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 251229007056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229007057 putative active site [active] 251229007058 heme pocket [chemical binding]; other site 251229007059 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229007060 dimer interface [polypeptide binding]; other site 251229007061 phosphorylation site [posttranslational modification] 251229007062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229007063 ATP binding site [chemical binding]; other site 251229007064 Mg2+ binding site [ion binding]; other site 251229007065 G-X-G motif; other site 251229007066 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229007067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229007068 active site 251229007069 phosphorylation site [posttranslational modification] 251229007070 intermolecular recognition site; other site 251229007071 dimerization interface [polypeptide binding]; other site 251229007072 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 251229007073 CoA binding domain; Region: CoA_binding_2; pfam13380 251229007074 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 251229007075 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 251229007076 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 251229007077 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 251229007078 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 251229007079 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 251229007080 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 251229007081 dimerization interface [polypeptide binding]; other site 251229007082 substrate binding pocket [chemical binding]; other site 251229007083 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 251229007084 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229007085 Coenzyme A binding pocket [chemical binding]; other site 251229007086 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 251229007087 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 251229007088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229007089 homodimer interface [polypeptide binding]; other site 251229007090 catalytic residue [active] 251229007091 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229007092 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229007093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 251229007094 S-adenosylmethionine binding site [chemical binding]; other site 251229007095 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 251229007096 catalytic triad [active] 251229007097 dimer interface [polypeptide binding]; other site 251229007098 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 251229007099 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 251229007100 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 251229007101 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 251229007102 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 251229007103 Walker A/P-loop; other site 251229007104 ATP binding site [chemical binding]; other site 251229007105 Q-loop/lid; other site 251229007106 ABC transporter signature motif; other site 251229007107 Walker B; other site 251229007108 D-loop; other site 251229007109 H-loop/switch region; other site 251229007110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229007111 dimer interface [polypeptide binding]; other site 251229007112 conserved gate region; other site 251229007113 ABC-ATPase subunit interface; other site 251229007114 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 251229007115 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 251229007116 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229007117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229007118 active site 251229007119 phosphorylation site [posttranslational modification] 251229007120 intermolecular recognition site; other site 251229007121 dimerization interface [polypeptide binding]; other site 251229007122 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229007123 DNA binding site [nucleotide binding] 251229007124 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 251229007125 biotin synthase; Validated; Region: PRK06256 251229007126 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251229007127 FeS/SAM binding site; other site 251229007128 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 251229007129 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 251229007130 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 251229007131 inhibitor-cofactor binding pocket; inhibition site 251229007132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229007133 catalytic residue [active] 251229007134 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 251229007135 Ycf35; Provisional; Region: ycf35; CHL00193 251229007136 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 251229007137 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 251229007138 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 251229007139 MutS domain III; Region: MutS_III; pfam05192 251229007140 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 251229007141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229007142 Walker A/P-loop; other site 251229007143 ATP binding site [chemical binding]; other site 251229007144 Q-loop/lid; other site 251229007145 ABC transporter signature motif; other site 251229007146 D-loop; other site 251229007147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229007148 Walker B; other site 251229007149 D-loop; other site 251229007150 H-loop/switch region; other site 251229007151 Smr domain; Region: Smr; pfam01713 251229007152 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 251229007153 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 251229007154 active site 251229007155 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 251229007156 catalytic residues [active] 251229007157 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 251229007158 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 251229007159 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 251229007160 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 251229007161 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251229007162 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229007163 AMIN domain; Region: AMIN; pfam11741 251229007164 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 251229007165 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229007166 N-terminal plug; other site 251229007167 ligand-binding site [chemical binding]; other site 251229007168 AMIN domain; Region: AMIN; pfam11741 251229007169 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251229007170 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229007171 N-terminal plug; other site 251229007172 ligand-binding site [chemical binding]; other site 251229007173 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 251229007174 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 251229007175 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 251229007176 Cytochrome P450; Region: p450; pfam00067 251229007177 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 251229007178 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 251229007179 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 251229007180 active site 251229007181 catalytic site [active] 251229007182 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229007183 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229007184 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 251229007185 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 251229007186 NADP-binding site; other site 251229007187 homotetramer interface [polypeptide binding]; other site 251229007188 substrate binding site [chemical binding]; other site 251229007189 homodimer interface [polypeptide binding]; other site 251229007190 active site 251229007191 Right handed beta helix region; Region: Beta_helix; pfam13229 251229007192 Response regulator receiver domain; Region: Response_reg; pfam00072 251229007193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229007194 active site 251229007195 phosphorylation site [posttranslational modification] 251229007196 intermolecular recognition site; other site 251229007197 dimerization interface [polypeptide binding]; other site 251229007198 Bacterial sugar transferase; Region: Bac_transf; cl00939 251229007199 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229007200 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 251229007201 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251229007202 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229007203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229007204 Walker A/P-loop; other site 251229007205 ATP binding site [chemical binding]; other site 251229007206 Q-loop/lid; other site 251229007207 ABC transporter signature motif; other site 251229007208 Walker B; other site 251229007209 D-loop; other site 251229007210 H-loop/switch region; other site 251229007211 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 251229007212 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229007213 active site 251229007214 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229007215 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 251229007216 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 251229007217 NAD binding site [chemical binding]; other site 251229007218 substrate binding site [chemical binding]; other site 251229007219 homodimer interface [polypeptide binding]; other site 251229007220 active site 251229007221 S-adenosylmethionine synthetase; Validated; Region: PRK05250 251229007222 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 251229007223 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 251229007224 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 251229007225 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 251229007226 FAD binding site [chemical binding]; other site 251229007227 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229007228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229007229 S-adenosylmethionine binding site [chemical binding]; other site 251229007230 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 251229007231 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 251229007232 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229007233 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 251229007234 active site 251229007235 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 251229007236 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 251229007237 putative active site [active] 251229007238 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 251229007239 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 251229007240 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 251229007241 Ligand binding site; other site 251229007242 oligomer interface; other site 251229007243 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 251229007244 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 251229007245 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 251229007246 Ligand binding site; other site 251229007247 metal-binding site 251229007248 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 251229007249 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 251229007250 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 251229007251 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229007252 active site 251229007253 motif I; other site 251229007254 motif II; other site 251229007255 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 251229007256 metal-binding site 251229007257 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 251229007258 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 251229007259 TPR repeat; Region: TPR_11; pfam13414 251229007260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229007261 binding surface 251229007262 TPR motif; other site 251229007263 TPR repeat; Region: TPR_11; pfam13414 251229007264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229007265 binding surface 251229007266 TPR motif; other site 251229007267 TPR repeat; Region: TPR_11; pfam13414 251229007268 TPR repeat; Region: TPR_11; pfam13414 251229007269 TPR repeat; Region: TPR_11; pfam13414 251229007270 TPR repeat; Region: TPR_11; pfam13414 251229007271 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229007272 binding surface 251229007273 TPR motif; other site 251229007274 TPR repeat; Region: TPR_11; pfam13414 251229007275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229007276 binding surface 251229007277 TPR motif; other site 251229007278 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229007279 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229007280 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229007281 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229007282 Predicted transcriptional regulators [Transcription]; Region: COG1695 251229007283 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 251229007284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 251229007285 non-specific DNA binding site [nucleotide binding]; other site 251229007286 salt bridge; other site 251229007287 sequence-specific DNA binding site [nucleotide binding]; other site 251229007288 PRC-barrel domain; Region: PRC; pfam05239 251229007289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 251229007290 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 251229007291 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 251229007292 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 251229007293 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 251229007294 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 251229007295 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 251229007296 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 251229007297 B12 binding site [chemical binding]; other site 251229007298 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251229007299 FeS/SAM binding site; other site 251229007300 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 251229007301 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 251229007302 Fatty acid desaturase; Region: FA_desaturase; pfam00487 251229007303 Di-iron ligands [ion binding]; other site 251229007304 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 251229007305 RNA recognition motif; Region: RRM; smart00360 251229007306 Phycobilisome protein; Region: Phycobilisome; cl08227 251229007307 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 251229007308 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 251229007309 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 251229007310 Fasciclin domain; Region: Fasciclin; pfam02469 251229007311 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 251229007312 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251229007313 Ligand Binding Site [chemical binding]; other site 251229007314 PqqA family; Region: PqqA; cl15372 251229007315 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 251229007316 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 251229007317 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251229007318 FeS/SAM binding site; other site 251229007319 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 251229007320 PRC-barrel domain; Region: PRC; pfam05239 251229007321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 251229007322 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 251229007323 homotrimer interaction site [polypeptide binding]; other site 251229007324 putative active site [active] 251229007325 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 251229007326 nudix motif; other site 251229007327 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 251229007328 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 251229007329 putative ligand binding site [chemical binding]; other site 251229007330 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 251229007331 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 251229007332 NlpC/P60 family; Region: NLPC_P60; pfam00877 251229007333 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 251229007334 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 251229007335 Putative Catalytic site; other site 251229007336 DXD motif; other site 251229007337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229007338 Major Facilitator Superfamily; Region: MFS_1; pfam07690 251229007339 putative substrate translocation pore; other site 251229007340 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 251229007341 trimer interface [polypeptide binding]; other site 251229007342 dimer interface [polypeptide binding]; other site 251229007343 putative active site [active] 251229007344 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 251229007345 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 251229007346 ligand binding site [chemical binding]; other site 251229007347 hypothetical protein; Provisional; Region: PRK02509 251229007348 Uncharacterized conserved protein [Function unknown]; Region: COG1615 251229007349 Response regulator receiver domain; Region: Response_reg; pfam00072 251229007350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229007351 active site 251229007352 phosphorylation site [posttranslational modification] 251229007353 intermolecular recognition site; other site 251229007354 dimerization interface [polypeptide binding]; other site 251229007355 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229007356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229007357 active site 251229007358 phosphorylation site [posttranslational modification] 251229007359 intermolecular recognition site; other site 251229007360 dimerization interface [polypeptide binding]; other site 251229007361 CheW-like domain; Region: CheW; pfam01584 251229007362 Cache domain; Region: Cache_1; pfam02743 251229007363 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 251229007364 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 251229007365 dimer interface [polypeptide binding]; other site 251229007366 putative CheW interface [polypeptide binding]; other site 251229007367 Cache domain; Region: Cache_1; pfam02743 251229007368 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 251229007369 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229007370 dimerization interface [polypeptide binding]; other site 251229007371 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 251229007372 dimer interface [polypeptide binding]; other site 251229007373 putative CheW interface [polypeptide binding]; other site 251229007374 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 251229007375 putative binding surface; other site 251229007376 active site 251229007377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229007378 ATP binding site [chemical binding]; other site 251229007379 Mg2+ binding site [ion binding]; other site 251229007380 G-X-G motif; other site 251229007381 Response regulator receiver domain; Region: Response_reg; pfam00072 251229007382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229007383 active site 251229007384 phosphorylation site [posttranslational modification] 251229007385 intermolecular recognition site; other site 251229007386 dimerization interface [polypeptide binding]; other site 251229007387 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 251229007388 catalytic site [active] 251229007389 putative active site [active] 251229007390 putative substrate binding site [chemical binding]; other site 251229007391 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 251229007392 amidase catalytic site [active] 251229007393 Zn binding residues [ion binding]; other site 251229007394 substrate binding site [chemical binding]; other site 251229007395 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 251229007396 putative rRNA binding site [nucleotide binding]; other site 251229007397 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 251229007398 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 251229007399 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 251229007400 homodimer interface [polypeptide binding]; other site 251229007401 Walker A motif; other site 251229007402 ATP binding site [chemical binding]; other site 251229007403 hydroxycobalamin binding site [chemical binding]; other site 251229007404 Walker B motif; other site 251229007405 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 251229007406 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 251229007407 putative active site [active] 251229007408 Zn binding site [ion binding]; other site 251229007409 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 251229007410 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 251229007411 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 251229007412 putative dimer interface [polypeptide binding]; other site 251229007413 N-terminal domain interface [polypeptide binding]; other site 251229007414 putative substrate binding pocket (H-site) [chemical binding]; other site 251229007415 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251229007416 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229007417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229007418 Walker A/P-loop; other site 251229007419 ATP binding site [chemical binding]; other site 251229007420 Q-loop/lid; other site 251229007421 ABC transporter signature motif; other site 251229007422 Walker B; other site 251229007423 D-loop; other site 251229007424 H-loop/switch region; other site 251229007425 XisI protein; Region: XisI; pfam08869 251229007426 Protein of unknown function (DUF433); Region: DUF433; cl01030 251229007427 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 251229007428 putative active site [active] 251229007429 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 251229007430 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 251229007431 siderophore binding site; other site 251229007432 AMIN domain; Region: AMIN; pfam11741 251229007433 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251229007434 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229007435 N-terminal plug; other site 251229007436 ligand-binding site [chemical binding]; other site 251229007437 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 251229007438 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229007439 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251229007440 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229007441 AMIN domain; Region: AMIN; pfam11741 251229007442 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 251229007443 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229007444 N-terminal plug; other site 251229007445 ligand-binding site [chemical binding]; other site 251229007446 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 251229007447 putative dimer interface [polypeptide binding]; other site 251229007448 putative [2Fe-2S] cluster binding site [ion binding]; other site 251229007449 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 251229007450 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 251229007451 siderophore binding site; other site 251229007452 Uncharacterized conserved protein [Function unknown]; Region: COG5464 251229007453 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 251229007454 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 251229007455 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 251229007456 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 251229007457 siderophore binding site; other site 251229007458 AMIN domain; Region: AMIN; pfam11741 251229007459 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251229007460 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229007461 N-terminal plug; other site 251229007462 ligand-binding site [chemical binding]; other site 251229007463 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 251229007464 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229007465 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 251229007466 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 251229007467 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 251229007468 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251229007469 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 251229007470 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251229007471 DNA binding residues [nucleotide binding] 251229007472 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251229007473 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 251229007474 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 251229007475 putative switch regulator; other site 251229007476 non-specific DNA interactions [nucleotide binding]; other site 251229007477 DNA binding site [nucleotide binding] 251229007478 sequence specific DNA binding site [nucleotide binding]; other site 251229007479 putative cAMP binding site [chemical binding]; other site 251229007480 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 251229007481 CoA binding site [chemical binding]; other site 251229007482 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229007483 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 251229007484 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 251229007485 Condensation domain; Region: Condensation; pfam00668 251229007486 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229007487 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 251229007488 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 251229007489 acyl-activating enzyme (AAE) consensus motif; other site 251229007490 active site 251229007491 AMP binding site [chemical binding]; other site 251229007492 CoA binding site [chemical binding]; other site 251229007493 Condensation domain; Region: Condensation; pfam00668 251229007494 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229007495 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 251229007496 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 251229007497 acyl-activating enzyme (AAE) consensus motif; other site 251229007498 active site 251229007499 AMP binding site [chemical binding]; other site 251229007500 CoA binding site [chemical binding]; other site 251229007501 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229007502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229007503 S-adenosylmethionine binding site [chemical binding]; other site 251229007504 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 251229007505 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229007506 Condensation domain; Region: Condensation; pfam00668 251229007507 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229007508 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 251229007509 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 251229007510 acyl-activating enzyme (AAE) consensus motif; other site 251229007511 AMP binding site [chemical binding]; other site 251229007512 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229007513 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 251229007514 putative active site [active] 251229007515 redox center [active] 251229007516 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 251229007517 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 251229007518 Tetramer interface [polypeptide binding]; other site 251229007519 active site 251229007520 FMN-binding site [chemical binding]; other site 251229007521 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 251229007522 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 251229007523 cell division protein FtsZ; Validated; Region: PRK09330 251229007524 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 251229007525 nucleotide binding site [chemical binding]; other site 251229007526 SulA interaction site; other site 251229007527 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 251229007528 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 251229007529 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 251229007530 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 251229007531 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 251229007532 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 251229007533 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 251229007534 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 251229007535 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 251229007536 dimer interface [polypeptide binding]; other site 251229007537 putative anticodon binding site; other site 251229007538 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 251229007539 motif 1; other site 251229007540 active site 251229007541 motif 2; other site 251229007542 motif 3; other site 251229007543 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 251229007544 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 251229007545 Walker A/P-loop; other site 251229007546 ATP binding site [chemical binding]; other site 251229007547 Q-loop/lid; other site 251229007548 ABC transporter signature motif; other site 251229007549 Walker B; other site 251229007550 D-loop; other site 251229007551 H-loop/switch region; other site 251229007552 intracellular protease, PfpI family; Region: PfpI; TIGR01382 251229007553 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 251229007554 conserved cys residue [active] 251229007555 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 251229007556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229007557 Walker A/P-loop; other site 251229007558 ATP binding site [chemical binding]; other site 251229007559 Q-loop/lid; other site 251229007560 exonuclease SbcC; Region: sbcc; TIGR00618 251229007561 Rad50 zinc hook motif; Region: Rad50_zn_hook; pfam04423 251229007562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229007563 ABC transporter signature motif; other site 251229007564 Walker B; other site 251229007565 D-loop; other site 251229007566 H-loop/switch region; other site 251229007567 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 251229007568 putative active site pocket [active] 251229007569 dimerization interface [polypeptide binding]; other site 251229007570 putative catalytic residue [active] 251229007571 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 251229007572 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 251229007573 active site residue [active] 251229007574 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 251229007575 active site residue [active] 251229007576 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 251229007577 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 251229007578 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 251229007579 Active_site [active] 251229007580 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229007581 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229007582 active site 251229007583 ATP binding site [chemical binding]; other site 251229007584 substrate binding site [chemical binding]; other site 251229007585 activation loop (A-loop); other site 251229007586 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229007587 structural tetrad; other site 251229007588 PQQ-like domain; Region: PQQ_2; pfam13360 251229007589 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 251229007590 CoA binding domain; Region: CoA_binding; smart00881 251229007591 CoA-ligase; Region: Ligase_CoA; pfam00549 251229007592 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 251229007593 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 251229007594 CoA-ligase; Region: Ligase_CoA; pfam00549 251229007595 short chain dehydrogenase; Validated; Region: PRK06182 251229007596 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 251229007597 NADP binding site [chemical binding]; other site 251229007598 active site 251229007599 steroid binding site; other site 251229007600 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 251229007601 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 251229007602 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229007603 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229007604 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229007605 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229007606 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 251229007607 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 251229007608 30S subunit binding site; other site 251229007609 TPR repeat; Region: TPR_11; pfam13414 251229007610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229007611 binding surface 251229007612 TPR motif; other site 251229007613 TPR repeat; Region: TPR_11; pfam13414 251229007614 Tetratricopeptide repeat; Region: TPR_16; pfam13432 251229007615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 251229007616 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 251229007617 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 251229007618 PAS domain S-box; Region: sensory_box; TIGR00229 251229007619 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229007620 putative active site [active] 251229007621 heme pocket [chemical binding]; other site 251229007622 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229007623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229007624 dimer interface [polypeptide binding]; other site 251229007625 phosphorylation site [posttranslational modification] 251229007626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229007627 ATP binding site [chemical binding]; other site 251229007628 Mg2+ binding site [ion binding]; other site 251229007629 G-X-G motif; other site 251229007630 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 251229007631 FAD binding domain; Region: FAD_binding_4; pfam01565 251229007632 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 251229007633 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 251229007634 Cysteine-rich domain; Region: CCG; pfam02754 251229007635 Cysteine-rich domain; Region: CCG; pfam02754 251229007636 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 251229007637 putative active site [active] 251229007638 dimerization interface [polypeptide binding]; other site 251229007639 putative tRNAtyr binding site [nucleotide binding]; other site 251229007640 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229007641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229007642 active site 251229007643 phosphorylation site [posttranslational modification] 251229007644 intermolecular recognition site; other site 251229007645 dimerization interface [polypeptide binding]; other site 251229007646 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229007647 DNA binding site [nucleotide binding] 251229007648 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 251229007649 putative binding surface; other site 251229007650 active site 251229007651 Response regulator receiver domain; Region: Response_reg; pfam00072 251229007652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229007653 active site 251229007654 phosphorylation site [posttranslational modification] 251229007655 intermolecular recognition site; other site 251229007656 dimerization interface [polypeptide binding]; other site 251229007657 Response regulator receiver domain; Region: Response_reg; pfam00072 251229007658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229007659 active site 251229007660 phosphorylation site [posttranslational modification] 251229007661 intermolecular recognition site; other site 251229007662 dimerization interface [polypeptide binding]; other site 251229007663 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229007664 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251229007665 putative active site [active] 251229007666 heme pocket [chemical binding]; other site 251229007667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229007668 dimer interface [polypeptide binding]; other site 251229007669 phosphorylation site [posttranslational modification] 251229007670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229007671 ATP binding site [chemical binding]; other site 251229007672 Mg2+ binding site [ion binding]; other site 251229007673 G-X-G motif; other site 251229007674 Response regulator receiver domain; Region: Response_reg; pfam00072 251229007675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229007676 active site 251229007677 phosphorylation site [posttranslational modification] 251229007678 intermolecular recognition site; other site 251229007679 dimerization interface [polypeptide binding]; other site 251229007680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229007681 active site 251229007682 phosphorylation site [posttranslational modification] 251229007683 intermolecular recognition site; other site 251229007684 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229007685 dimerization interface [polypeptide binding]; other site 251229007686 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251229007687 Ligand Binding Site [chemical binding]; other site 251229007688 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 251229007689 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 251229007690 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 251229007691 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 251229007692 Mechanosensitive ion channel; Region: MS_channel; pfam00924 251229007693 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 251229007694 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 251229007695 homotetramer interface [polypeptide binding]; other site 251229007696 ligand binding site [chemical binding]; other site 251229007697 catalytic site [active] 251229007698 NAD binding site [chemical binding]; other site 251229007699 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 251229007700 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 251229007701 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251229007702 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229007703 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 251229007704 Walker A/P-loop; other site 251229007705 ATP binding site [chemical binding]; other site 251229007706 Q-loop/lid; other site 251229007707 ABC transporter signature motif; other site 251229007708 Walker B; other site 251229007709 D-loop; other site 251229007710 H-loop/switch region; other site 251229007711 HicB family; Region: HicB; pfam05534 251229007712 PIN domain; Region: PIN_3; pfam13470 251229007713 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 251229007714 Cytochrome c; Region: Cytochrom_C; pfam00034 251229007715 cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665 251229007716 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 251229007717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229007718 S-adenosylmethionine binding site [chemical binding]; other site 251229007719 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 251229007720 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 251229007721 putative active site [active] 251229007722 oxyanion strand; other site 251229007723 catalytic triad [active] 251229007724 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 251229007725 putative substrate binding pocket [chemical binding]; other site 251229007726 AC domain interface; other site 251229007727 catalytic triad [active] 251229007728 AB domain interface; other site 251229007729 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 251229007730 Beta-lactamase; Region: Beta-lactamase; pfam00144 251229007731 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 251229007732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229007733 Coenzyme A binding pocket [chemical binding]; other site 251229007734 muropeptide transporter; Validated; Region: ampG; cl17669 251229007735 muropeptide transporter; Validated; Region: ampG; cl17669 251229007736 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 251229007737 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 251229007738 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 251229007739 Protein kinase domain; Region: Pkinase; pfam00069 251229007740 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229007741 active site 251229007742 ATP binding site [chemical binding]; other site 251229007743 substrate binding site [chemical binding]; other site 251229007744 activation loop (A-loop); other site 251229007745 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229007746 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229007747 structural tetrad; other site 251229007748 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251229007749 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 251229007750 putative switch regulator; other site 251229007751 non-specific DNA interactions [nucleotide binding]; other site 251229007752 DNA binding site [nucleotide binding] 251229007753 sequence specific DNA binding site [nucleotide binding]; other site 251229007754 putative cAMP binding site [chemical binding]; other site 251229007755 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 251229007756 active site 251229007757 catalytic site [active] 251229007758 substrate binding site [chemical binding]; other site 251229007759 TPR repeat; Region: TPR_11; pfam13414 251229007760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229007761 binding surface 251229007762 TPR motif; other site 251229007763 TPR repeat; Region: TPR_11; pfam13414 251229007764 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 251229007765 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 251229007766 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 251229007767 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 251229007768 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229007769 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251229007770 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229007771 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 251229007772 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 251229007773 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 251229007774 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 251229007775 active site 251229007776 Zn binding site [ion binding]; other site 251229007777 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 251229007778 DNA gyrase subunit A; Validated; Region: PRK05560 251229007779 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 251229007780 CAP-like domain; other site 251229007781 active site 251229007782 primary dimer interface [polypeptide binding]; other site 251229007783 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 251229007784 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 251229007785 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 251229007786 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 251229007787 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 251229007788 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 251229007789 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 251229007790 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 251229007791 putative active site [active] 251229007792 catalytic triad [active] 251229007793 putative dimer interface [polypeptide binding]; other site 251229007794 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229007795 putative active site [active] 251229007796 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 251229007797 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 251229007798 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 251229007799 active site 251229007800 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 251229007801 Maf-like protein; Region: Maf; pfam02545 251229007802 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 251229007803 active site 251229007804 dimer interface [polypeptide binding]; other site 251229007805 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 251229007806 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 251229007807 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 251229007808 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 251229007809 minor groove reading motif; other site 251229007810 helix-hairpin-helix signature motif; other site 251229007811 substrate binding pocket [chemical binding]; other site 251229007812 active site 251229007813 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 251229007814 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 251229007815 2TM domain; Region: 2TM; pfam13239 251229007816 TPR repeat; Region: TPR_11; pfam13414 251229007817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229007818 binding surface 251229007819 TPR motif; other site 251229007820 Tetratricopeptide repeat; Region: TPR_9; pfam13371 251229007821 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 251229007822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229007823 Walker A/P-loop; other site 251229007824 ATP binding site [chemical binding]; other site 251229007825 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229007826 putative active site [active] 251229007827 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229007828 putative active site [active] 251229007829 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 251229007830 DNA-sulfur modification-associated; Region: DndB; cl17621 251229007831 DGQHR domain; Region: DGQHR; TIGR03187 251229007832 DNA-sulfur modification-associated; Region: DndB; cl17621 251229007833 hypothetical protein; Provisional; Region: PRK06850 251229007834 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 251229007835 Active Sites [active] 251229007836 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 251229007837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229007838 Walker A/P-loop; other site 251229007839 ATP binding site [chemical binding]; other site 251229007840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229007841 ABC transporter signature motif; other site 251229007842 Walker B; other site 251229007843 D-loop; other site 251229007844 H-loop/switch region; other site 251229007845 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 251229007846 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 251229007847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251229007848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 251229007849 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 251229007850 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 251229007851 Fatty acid desaturase; Region: FA_desaturase; pfam00487 251229007852 Di-iron ligands [ion binding]; other site 251229007853 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 251229007854 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 251229007855 active site 251229007856 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 251229007857 CHASE4 domain; Region: CHASE4; cl01308 251229007858 PAS domain S-box; Region: sensory_box; TIGR00229 251229007859 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229007860 putative active site [active] 251229007861 heme pocket [chemical binding]; other site 251229007862 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229007863 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229007864 metal binding site [ion binding]; metal-binding site 251229007865 active site 251229007866 I-site; other site 251229007867 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 251229007868 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 251229007869 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229007870 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 251229007871 putative active site [active] 251229007872 heme pocket [chemical binding]; other site 251229007873 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229007874 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 251229007875 putative active site [active] 251229007876 heme pocket [chemical binding]; other site 251229007877 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229007878 putative active site [active] 251229007879 heme pocket [chemical binding]; other site 251229007880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229007881 dimer interface [polypeptide binding]; other site 251229007882 phosphorylation site [posttranslational modification] 251229007883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229007884 ATP binding site [chemical binding]; other site 251229007885 Mg2+ binding site [ion binding]; other site 251229007886 G-X-G motif; other site 251229007887 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229007888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229007889 active site 251229007890 phosphorylation site [posttranslational modification] 251229007891 intermolecular recognition site; other site 251229007892 dimerization interface [polypeptide binding]; other site 251229007893 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229007894 DNA binding site [nucleotide binding] 251229007895 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 251229007896 putative binding surface; other site 251229007897 active site 251229007898 Response regulator receiver domain; Region: Response_reg; pfam00072 251229007899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229007900 active site 251229007901 phosphorylation site [posttranslational modification] 251229007902 intermolecular recognition site; other site 251229007903 Response regulator receiver domain; Region: Response_reg; pfam00072 251229007904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229007905 active site 251229007906 phosphorylation site [posttranslational modification] 251229007907 intermolecular recognition site; other site 251229007908 dimerization interface [polypeptide binding]; other site 251229007909 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 251229007910 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 251229007911 Malic enzyme, N-terminal domain; Region: malic; pfam00390 251229007912 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 251229007913 putative NAD(P) binding site [chemical binding]; other site 251229007914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229007915 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 251229007916 Coenzyme A binding pocket [chemical binding]; other site 251229007917 argininosuccinate synthase; Provisional; Region: PRK13820 251229007918 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 251229007919 ANP binding site [chemical binding]; other site 251229007920 Substrate Binding Site II [chemical binding]; other site 251229007921 Substrate Binding Site I [chemical binding]; other site 251229007922 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 251229007923 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 251229007924 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 251229007925 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 251229007926 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 251229007927 ATP-grasp domain; Region: ATP-grasp_4; cl17255 251229007928 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 251229007929 IMP binding site; other site 251229007930 dimer interface [polypeptide binding]; other site 251229007931 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229007932 putative active site [active] 251229007933 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 251229007934 catalytic core [active] 251229007935 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 251229007936 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 251229007937 MoaE interaction surface [polypeptide binding]; other site 251229007938 MoeB interaction surface [polypeptide binding]; other site 251229007939 thiocarboxylated glycine; other site 251229007940 Clp protease; Region: CLP_protease; pfam00574 251229007941 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 251229007942 oligomer interface [polypeptide binding]; other site 251229007943 active site residues [active] 251229007944 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 251229007945 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 251229007946 oligomer interface [polypeptide binding]; other site 251229007947 active site residues [active] 251229007948 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 251229007949 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 251229007950 metal ion-dependent adhesion site (MIDAS); other site 251229007951 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 251229007952 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251229007953 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 251229007954 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 251229007955 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 251229007956 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 251229007957 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 251229007958 iron-sulfur cluster [ion binding]; other site 251229007959 [2Fe-2S] cluster binding site [ion binding]; other site 251229007960 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 251229007961 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 251229007962 OsmC-like protein; Region: OsmC; pfam02566 251229007963 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 251229007964 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 251229007965 active site 251229007966 NMT1-like family; Region: NMT1_2; pfam13379 251229007967 NMT1/THI5 like; Region: NMT1; pfam09084 251229007968 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 251229007969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229007970 dimer interface [polypeptide binding]; other site 251229007971 conserved gate region; other site 251229007972 putative PBP binding loops; other site 251229007973 ABC-ATPase subunit interface; other site 251229007974 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 251229007975 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 251229007976 Walker A/P-loop; other site 251229007977 ATP binding site [chemical binding]; other site 251229007978 Q-loop/lid; other site 251229007979 ABC transporter signature motif; other site 251229007980 Walker B; other site 251229007981 D-loop; other site 251229007982 H-loop/switch region; other site 251229007983 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251229007984 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 251229007985 light-harvesting-like protein 3; Provisional; Region: PLN00014 251229007986 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 251229007987 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 251229007988 hexamer interface [polypeptide binding]; other site 251229007989 ligand binding site [chemical binding]; other site 251229007990 putative active site [active] 251229007991 NAD(P) binding site [chemical binding]; other site 251229007992 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 251229007993 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 251229007994 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 251229007995 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 251229007996 nudix motif; other site 251229007997 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 251229007998 Phosphotransferase enzyme family; Region: APH; pfam01636 251229007999 active site 251229008000 substrate binding site [chemical binding]; other site 251229008001 ATP binding site [chemical binding]; other site 251229008002 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 251229008003 putative heme binding site [chemical binding]; other site 251229008004 Helix-turn-helix domain; Region: HTH_39; pfam14090 251229008005 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 251229008006 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 251229008007 Predicted membrane protein [Function unknown]; Region: COG4325 251229008008 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 251229008009 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 251229008010 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 251229008011 Ligand Binding Site [chemical binding]; other site 251229008012 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 251229008013 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 251229008014 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 251229008015 Ligand Binding Site [chemical binding]; other site 251229008016 Response regulator receiver domain; Region: Response_reg; pfam00072 251229008017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229008018 active site 251229008019 phosphorylation site [posttranslational modification] 251229008020 intermolecular recognition site; other site 251229008021 dimerization interface [polypeptide binding]; other site 251229008022 polyphosphate kinase; Provisional; Region: PRK05443 251229008023 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 251229008024 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 251229008025 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 251229008026 putative domain interface [polypeptide binding]; other site 251229008027 putative active site [active] 251229008028 catalytic site [active] 251229008029 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 251229008030 putative domain interface [polypeptide binding]; other site 251229008031 putative active site [active] 251229008032 catalytic site [active] 251229008033 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 251229008034 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 251229008035 SLBB domain; Region: SLBB; pfam10531 251229008036 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 251229008037 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 251229008038 putative active site pocket [active] 251229008039 4-fold oligomerization interface [polypeptide binding]; other site 251229008040 metal binding residues [ion binding]; metal-binding site 251229008041 3-fold/trimer interface [polypeptide binding]; other site 251229008042 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 251229008043 Mechanosensitive ion channel; Region: MS_channel; pfam00924 251229008044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229008045 BT1 family; Region: BT1; pfam03092 251229008046 putative substrate translocation pore; other site 251229008047 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 251229008048 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 251229008049 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 251229008050 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229008051 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229008052 active site 251229008053 ATP binding site [chemical binding]; other site 251229008054 substrate binding site [chemical binding]; other site 251229008055 activation loop (A-loop); other site 251229008056 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 251229008057 peripheral dimer interface [polypeptide binding]; other site 251229008058 core dimer interface [polypeptide binding]; other site 251229008059 L10 interface [polypeptide binding]; other site 251229008060 L11 interface [polypeptide binding]; other site 251229008061 putative EF-Tu interaction site [polypeptide binding]; other site 251229008062 putative EF-G interaction site [polypeptide binding]; other site 251229008063 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 251229008064 23S rRNA interface [nucleotide binding]; other site 251229008065 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 251229008066 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 251229008067 mRNA/rRNA interface [nucleotide binding]; other site 251229008068 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 251229008069 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 251229008070 23S rRNA interface [nucleotide binding]; other site 251229008071 L7/L12 interface [polypeptide binding]; other site 251229008072 putative thiostrepton binding site; other site 251229008073 L25 interface [polypeptide binding]; other site 251229008074 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 251229008075 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 251229008076 putative homodimer interface [polypeptide binding]; other site 251229008077 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 251229008078 heterodimer interface [polypeptide binding]; other site 251229008079 homodimer interface [polypeptide binding]; other site 251229008080 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 251229008081 ribosomal protein L19; Region: rpl19; CHL00084 251229008082 CpeS-like protein; Region: CpeS; pfam09367 251229008083 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 251229008084 Domain of unknown function (DUF3474); Region: DUF3474; pfam11960 251229008085 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 251229008086 putative di-iron ligands [ion binding]; other site 251229008087 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 251229008088 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 251229008089 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 251229008090 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 251229008091 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 251229008092 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 251229008093 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 251229008094 pantothenate kinase; Reviewed; Region: PRK13331 251229008095 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 251229008096 PemK-like protein; Region: PemK; pfam02452 251229008097 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 251229008098 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 251229008099 substrate binding site [chemical binding]; other site 251229008100 ATP binding site [chemical binding]; other site 251229008101 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229008102 putative active site [active] 251229008103 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 251229008104 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 251229008105 active site 251229008106 homodimer interface [polypeptide binding]; other site 251229008107 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 251229008108 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 251229008109 putative NAD(P) binding site [chemical binding]; other site 251229008110 homodimer interface [polypeptide binding]; other site 251229008111 homotetramer interface [polypeptide binding]; other site 251229008112 active site 251229008113 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 251229008114 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251229008115 dimerization interface [polypeptide binding]; other site 251229008116 putative DNA binding site [nucleotide binding]; other site 251229008117 putative Zn2+ binding site [ion binding]; other site 251229008118 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251229008119 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 251229008120 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229008121 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 251229008122 Protein export membrane protein; Region: SecD_SecF; cl14618 251229008123 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 251229008124 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 251229008125 inhibitor-cofactor binding pocket; inhibition site 251229008126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229008127 catalytic residue [active] 251229008128 recombination protein RecR; Reviewed; Region: recR; PRK00076 251229008129 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 251229008130 RecR protein; Region: RecR; pfam02132 251229008131 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 251229008132 putative active site [active] 251229008133 putative metal-binding site [ion binding]; other site 251229008134 tetramer interface [polypeptide binding]; other site 251229008135 PBP superfamily domain; Region: PBP_like_2; cl17296 251229008136 GTPase Era; Reviewed; Region: era; PRK00089 251229008137 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 251229008138 G1 box; other site 251229008139 GTP/Mg2+ binding site [chemical binding]; other site 251229008140 Switch I region; other site 251229008141 G2 box; other site 251229008142 Switch II region; other site 251229008143 G3 box; other site 251229008144 G4 box; other site 251229008145 G5 box; other site 251229008146 KH domain; Region: KH_2; pfam07650 251229008147 6-phosphofructokinase; Provisional; Region: PRK14071 251229008148 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 251229008149 active site 251229008150 ADP/pyrophosphate binding site [chemical binding]; other site 251229008151 dimerization interface [polypeptide binding]; other site 251229008152 allosteric effector site; other site 251229008153 fructose-1,6-bisphosphate binding site; other site 251229008154 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 251229008155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229008156 active site 251229008157 phosphorylation site [posttranslational modification] 251229008158 intermolecular recognition site; other site 251229008159 dimerization interface [polypeptide binding]; other site 251229008160 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 251229008161 Zn2+ binding site [ion binding]; other site 251229008162 Mg2+ binding site [ion binding]; other site 251229008163 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 251229008164 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 251229008165 enolase; Provisional; Region: eno; PRK00077 251229008166 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 251229008167 dimer interface [polypeptide binding]; other site 251229008168 metal binding site [ion binding]; metal-binding site 251229008169 substrate binding pocket [chemical binding]; other site 251229008170 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229008171 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 251229008172 dimer interface [polypeptide binding]; other site 251229008173 active site 251229008174 metal binding site [ion binding]; metal-binding site 251229008175 glutathione binding site [chemical binding]; other site 251229008176 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 251229008177 Clp amino terminal domain; Region: Clp_N; pfam02861 251229008178 Clp amino terminal domain; Region: Clp_N; pfam02861 251229008179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229008180 Walker A motif; other site 251229008181 ATP binding site [chemical binding]; other site 251229008182 Walker B motif; other site 251229008183 arginine finger; other site 251229008184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229008185 Walker A motif; other site 251229008186 ATP binding site [chemical binding]; other site 251229008187 Walker B motif; other site 251229008188 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 251229008189 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 251229008190 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 251229008191 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 251229008192 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 251229008193 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251229008194 active site 251229008195 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 251229008196 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 251229008197 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251229008198 active site 251229008199 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 251229008200 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251229008201 active site 251229008202 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 251229008203 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 251229008204 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 251229008205 active site 251229008206 catalytic residues [active] 251229008207 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 251229008208 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 251229008209 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229008210 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229008211 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229008212 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229008213 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 251229008214 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 251229008215 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 251229008216 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 251229008217 active site 251229008218 catalytic residues [active] 251229008219 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 251229008220 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 251229008221 MarR family; Region: MarR; pfam01047 251229008222 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 251229008223 dimer interface [polypeptide binding]; other site 251229008224 substrate binding site [chemical binding]; other site 251229008225 metal binding sites [ion binding]; metal-binding site 251229008226 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 251229008227 tetramerization interface [polypeptide binding]; other site 251229008228 active site 251229008229 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 251229008230 active site clefts [active] 251229008231 zinc binding site [ion binding]; other site 251229008232 dimer interface [polypeptide binding]; other site 251229008233 hypothetical protein; Provisional; Region: PRK07394 251229008234 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 251229008235 Transcriptional regulator [Transcription]; Region: LysR; COG0583 251229008236 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 251229008237 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 251229008238 dimerization interface [polypeptide binding]; other site 251229008239 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 251229008240 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 251229008241 nucleotide binding pocket [chemical binding]; other site 251229008242 K-X-D-G motif; other site 251229008243 catalytic site [active] 251229008244 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 251229008245 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 251229008246 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 251229008247 Dimer interface [polypeptide binding]; other site 251229008248 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 251229008249 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 251229008250 putative active site [active] 251229008251 catalytic site [active] 251229008252 putative metal binding site [ion binding]; other site 251229008253 Cache domain; Region: Cache_1; pfam02743 251229008254 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229008255 dimerization interface [polypeptide binding]; other site 251229008256 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251229008257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229008258 putative active site [active] 251229008259 heme pocket [chemical binding]; other site 251229008260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229008261 dimer interface [polypeptide binding]; other site 251229008262 phosphorylation site [posttranslational modification] 251229008263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229008264 ATP binding site [chemical binding]; other site 251229008265 Mg2+ binding site [ion binding]; other site 251229008266 G-X-G motif; other site 251229008267 YtpI-like protein; Region: YtpI; pfam14007 251229008268 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 251229008269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 251229008270 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 251229008271 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 251229008272 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 251229008273 Transcriptional regulators [Transcription]; Region: FadR; COG2186 251229008274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 251229008275 DNA-binding site [nucleotide binding]; DNA binding site 251229008276 FCD domain; Region: FCD; pfam07729 251229008277 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 251229008278 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229008279 motif II; other site 251229008280 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 251229008281 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 251229008282 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 251229008283 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 251229008284 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 251229008285 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229008286 Coenzyme A binding pocket [chemical binding]; other site 251229008287 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 251229008288 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 251229008289 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 251229008290 active site 251229008291 substrate binding site [chemical binding]; other site 251229008292 metal binding site [ion binding]; metal-binding site 251229008293 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 251229008294 active site 251229008295 dimerization interface [polypeptide binding]; other site 251229008296 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 251229008297 Nitrogen regulatory protein P-II; Region: P-II; smart00938 251229008298 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 251229008299 dimer interface [polypeptide binding]; other site 251229008300 substrate binding site [chemical binding]; other site 251229008301 ATP binding site [chemical binding]; other site 251229008302 Fatty acid desaturase; Region: FA_desaturase; pfam00487 251229008303 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 251229008304 putative di-iron ligands [ion binding]; other site 251229008305 methionine sulfoxide reductase A; Provisional; Region: PRK00058 251229008306 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 251229008307 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 251229008308 acyl-activating enzyme (AAE) consensus motif; other site 251229008309 CoA binding site [chemical binding]; other site 251229008310 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 251229008311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 251229008312 NAD-dependent deacetylase; Provisional; Region: PRK00481 251229008313 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 251229008314 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229008315 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229008316 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229008317 TPR repeat; Region: TPR_11; pfam13414 251229008318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229008319 TPR motif; other site 251229008320 Putative transcription activator [Transcription]; Region: TenA; COG0819 251229008321 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251229008322 putative DNA binding site [nucleotide binding]; other site 251229008323 PBP superfamily domain; Region: PBP_like_2; cl17296 251229008324 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 251229008325 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 251229008326 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 251229008327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229008328 putative substrate translocation pore; other site 251229008329 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 251229008330 arsenical-resistance protein; Region: acr3; TIGR00832 251229008331 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 251229008332 Low molecular weight phosphatase family; Region: LMWPc; cd00115 251229008333 active site 251229008334 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251229008335 dimerization interface [polypeptide binding]; other site 251229008336 putative DNA binding site [nucleotide binding]; other site 251229008337 putative Zn2+ binding site [ion binding]; other site 251229008338 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229008339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229008340 S-adenosylmethionine binding site [chemical binding]; other site 251229008341 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 251229008342 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229008343 active site 251229008344 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229008345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229008346 S-adenosylmethionine binding site [chemical binding]; other site 251229008347 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 251229008348 Methyltransferase domain; Region: Methyltransf_26; pfam13659 251229008349 muropeptide transporter; Reviewed; Region: ampG; PRK11902 251229008350 muropeptide transporter; Validated; Region: ampG; cl17669 251229008351 AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478 251229008352 [2Fe-2S] cluster binding site [ion binding]; other site 251229008353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 251229008354 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 251229008355 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 251229008356 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 251229008357 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 251229008358 putative active site [active] 251229008359 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 251229008360 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251229008361 FeS/SAM binding site; other site 251229008362 HemN C-terminal domain; Region: HemN_C; pfam06969 251229008363 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229008364 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 251229008365 putative ADP-binding pocket [chemical binding]; other site 251229008366 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 251229008367 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 251229008368 NAD(P) binding site [chemical binding]; other site 251229008369 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 251229008370 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 251229008371 dimerization interface [polypeptide binding]; other site 251229008372 DPS ferroxidase diiron center [ion binding]; other site 251229008373 ion pore; other site 251229008374 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 251229008375 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 251229008376 dimer interface [polypeptide binding]; other site 251229008377 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 251229008378 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 251229008379 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 251229008380 dimerization interface [polypeptide binding]; other site 251229008381 DPS ferroxidase diiron center [ion binding]; other site 251229008382 ion pore; other site 251229008383 ParB-like nuclease domain; Region: ParBc; cl02129 251229008384 Stage II sporulation protein; Region: SpoIID; pfam08486 251229008385 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 251229008386 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 251229008387 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251229008388 catalytic loop [active] 251229008389 iron binding site [ion binding]; other site 251229008390 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 251229008391 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 251229008392 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 251229008393 active site 251229008394 catalytic triad [active] 251229008395 oxyanion hole [active] 251229008396 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 251229008397 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 251229008398 Cl- selectivity filter; other site 251229008399 Cl- binding residues [ion binding]; other site 251229008400 pore gating glutamate residue; other site 251229008401 dimer interface [polypeptide binding]; other site 251229008402 H+/Cl- coupling transport residue; other site 251229008403 FOG: CBS domain [General function prediction only]; Region: COG0517 251229008404 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 251229008405 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 251229008406 Ligand Binding Site [chemical binding]; other site 251229008407 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251229008408 Ligand Binding Site [chemical binding]; other site 251229008409 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 251229008410 active site 251229008411 ribulose/triose binding site [chemical binding]; other site 251229008412 phosphate binding site [ion binding]; other site 251229008413 substrate (anthranilate) binding pocket [chemical binding]; other site 251229008414 product (indole) binding pocket [chemical binding]; other site 251229008415 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 251229008416 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 251229008417 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 251229008418 AMIN domain; Region: AMIN; pfam11741 251229008419 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251229008420 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229008421 N-terminal plug; other site 251229008422 ligand-binding site [chemical binding]; other site 251229008423 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 251229008424 putative active site [active] 251229008425 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 251229008426 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 251229008427 AAA ATPase domain; Region: AAA_16; pfam13191 251229008428 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251229008429 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 251229008430 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 251229008431 AAA ATPase domain; Region: AAA_16; pfam13191 251229008432 NACHT domain; Region: NACHT; pfam05729 251229008433 WD40 repeats; Region: WD40; smart00320 251229008434 WD40 repeats; Region: WD40; smart00320 251229008435 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229008436 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229008437 structural tetrad; other site 251229008438 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229008439 structural tetrad; other site 251229008440 SnoaL-like domain; Region: SnoaL_2; pfam12680 251229008441 TPR repeat; Region: TPR_11; pfam13414 251229008442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229008443 binding surface 251229008444 TPR motif; other site 251229008445 TPR repeat; Region: TPR_11; pfam13414 251229008446 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229008447 binding surface 251229008448 TPR motif; other site 251229008449 Cytochrome c; Region: Cytochrom_C; cl11414 251229008450 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 251229008451 Predicted transcriptional regulator [Transcription]; Region: COG3682 251229008452 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 251229008453 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 251229008454 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 251229008455 CoA-binding site [chemical binding]; other site 251229008456 ATP-binding [chemical binding]; other site 251229008457 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 251229008458 active site 251229008459 SAM binding site [chemical binding]; other site 251229008460 homodimer interface [polypeptide binding]; other site 251229008461 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 251229008462 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 251229008463 active site 251229008464 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229008465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229008466 S-adenosylmethionine binding site [chemical binding]; other site 251229008467 ferrochelatase; Reviewed; Region: hemH; PRK00035 251229008468 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 251229008469 active site 251229008470 C-terminal domain interface [polypeptide binding]; other site 251229008471 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 251229008472 active site 251229008473 N-terminal domain interface [polypeptide binding]; other site 251229008474 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 251229008475 RNA binding surface [nucleotide binding]; other site 251229008476 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229008477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229008478 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 251229008479 Protein of unknown function (DUF983); Region: DUF983; cl02211 251229008480 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 251229008481 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 251229008482 active site 251229008483 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 251229008484 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 251229008485 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 251229008486 dimer interface [polypeptide binding]; other site 251229008487 active site 251229008488 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 251229008489 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 251229008490 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 251229008491 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 251229008492 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 251229008493 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 251229008494 substrate binding site [chemical binding]; other site 251229008495 oxyanion hole (OAH) forming residues; other site 251229008496 trimer interface [polypeptide binding]; other site 251229008497 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 251229008498 acyl-activating enzyme (AAE) consensus motif; other site 251229008499 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 251229008500 putative AMP binding site [chemical binding]; other site 251229008501 putative active site [active] 251229008502 putative CoA binding site [chemical binding]; other site 251229008503 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 251229008504 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 251229008505 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 251229008506 proteobacterial sortase system OmpA family protein; Region: pdsO; TIGR03789 251229008507 aspartate aminotransferase; Provisional; Region: PRK05764 251229008508 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 251229008509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229008510 homodimer interface [polypeptide binding]; other site 251229008511 catalytic residue [active] 251229008512 Biofilm formation and stress response factor; Region: BsmA; pfam10014 251229008513 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251229008514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229008515 NAD(P) binding site [chemical binding]; other site 251229008516 active site 251229008517 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 251229008518 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 251229008519 substrate-cofactor binding pocket; other site 251229008520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229008521 catalytic residue [active] 251229008522 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 251229008523 ligand-binding site [chemical binding]; other site 251229008524 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 251229008525 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229008526 Coenzyme A binding pocket [chemical binding]; other site 251229008527 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 251229008528 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 251229008529 intersubunit interface [polypeptide binding]; other site 251229008530 active site 251229008531 Zn2+ binding site [ion binding]; other site 251229008532 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 251229008533 Cupin domain; Region: Cupin_2; cl17218 251229008534 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 251229008535 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251229008536 catalytic loop [active] 251229008537 iron binding site [ion binding]; other site 251229008538 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 251229008539 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 251229008540 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 251229008541 putative ADP-binding pocket [chemical binding]; other site 251229008542 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229008543 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 251229008544 active site 251229008545 metal binding site [ion binding]; metal-binding site 251229008546 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 251229008547 EamA-like transporter family; Region: EamA; pfam00892 251229008548 EamA-like transporter family; Region: EamA; pfam00892 251229008549 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 251229008550 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 251229008551 Sulfate transporter family; Region: Sulfate_transp; pfam00916 251229008552 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 251229008553 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251229008554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229008555 NAD(P) binding site [chemical binding]; other site 251229008556 active site 251229008557 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 251229008558 substrate binding site [chemical binding]; other site 251229008559 active site 251229008560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229008561 Major Facilitator Superfamily; Region: MFS_1; pfam07690 251229008562 putative substrate translocation pore; other site 251229008563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229008564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 251229008565 putative substrate translocation pore; other site 251229008566 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 251229008567 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 251229008568 active site 251229008569 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 251229008570 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251229008571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 251229008572 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 251229008573 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 251229008574 active site 251229008575 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 251229008576 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 251229008577 N-acetyl-D-glucosamine binding site [chemical binding]; other site 251229008578 catalytic residue [active] 251229008579 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 251229008580 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 251229008581 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 251229008582 active site 251229008583 DNA binding site [nucleotide binding] 251229008584 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 251229008585 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 251229008586 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 251229008587 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 251229008588 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 251229008589 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 251229008590 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 251229008591 DXD motif; other site 251229008592 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 251229008593 dimer interface [polypeptide binding]; other site 251229008594 substrate binding site [chemical binding]; other site 251229008595 catalytic triad [active] 251229008596 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 251229008597 dihydropteroate synthase; Region: DHPS; TIGR01496 251229008598 substrate binding pocket [chemical binding]; other site 251229008599 dimer interface [polypeptide binding]; other site 251229008600 inhibitor binding site; inhibition site 251229008601 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 251229008602 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 251229008603 CpeS-like protein; Region: CpeS; pfam09367 251229008604 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 251229008605 active site pocket [active] 251229008606 putative dimer interface [polypeptide binding]; other site 251229008607 putative cataytic base [active] 251229008608 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 251229008609 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 251229008610 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 251229008611 NADPH bind site [chemical binding]; other site 251229008612 putative FMN binding site [chemical binding]; other site 251229008613 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 251229008614 putative FMN binding site [chemical binding]; other site 251229008615 NADPH bind site [chemical binding]; other site 251229008616 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 251229008617 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 251229008618 trmE is a tRNA modification GTPase; Region: trmE; cd04164 251229008619 G1 box; other site 251229008620 GTP/Mg2+ binding site [chemical binding]; other site 251229008621 Switch I region; other site 251229008622 G2 box; other site 251229008623 Switch II region; other site 251229008624 G3 box; other site 251229008625 G4 box; other site 251229008626 G5 box; other site 251229008627 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 251229008628 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 251229008629 Chain length determinant protein; Region: Wzz; pfam02706 251229008630 Chain length determinant protein; Region: Wzz; cl15801 251229008631 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 251229008632 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 251229008633 Magnesium ion binding site [ion binding]; other site 251229008634 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 251229008635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229008636 dimer interface [polypeptide binding]; other site 251229008637 phosphorylation site [posttranslational modification] 251229008638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229008639 ATP binding site [chemical binding]; other site 251229008640 Mg2+ binding site [ion binding]; other site 251229008641 G-X-G motif; other site 251229008642 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 251229008643 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229008644 DevC protein; Region: devC; TIGR01185 251229008645 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251229008646 FtsX-like permease family; Region: FtsX; pfam02687 251229008647 DevC protein; Region: devC; TIGR01185 251229008648 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251229008649 FtsX-like permease family; Region: FtsX; pfam02687 251229008650 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 251229008651 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 251229008652 Walker A/P-loop; other site 251229008653 ATP binding site [chemical binding]; other site 251229008654 Q-loop/lid; other site 251229008655 ABC transporter signature motif; other site 251229008656 Walker B; other site 251229008657 D-loop; other site 251229008658 H-loop/switch region; other site 251229008659 acetyl-CoA synthetase; Provisional; Region: PRK00174 251229008660 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 251229008661 active site 251229008662 CoA binding site [chemical binding]; other site 251229008663 acyl-activating enzyme (AAE) consensus motif; other site 251229008664 AMP binding site [chemical binding]; other site 251229008665 acetate binding site [chemical binding]; other site 251229008666 Integral membrane protein TerC family; Region: TerC; cl10468 251229008667 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 251229008668 active site 251229008669 multimer interface [polypeptide binding]; other site 251229008670 arginine decarboxylase; Provisional; Region: PRK05354 251229008671 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 251229008672 dimer interface [polypeptide binding]; other site 251229008673 active site 251229008674 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 251229008675 catalytic residues [active] 251229008676 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 251229008677 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 251229008678 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 251229008679 active site 251229008680 Substrate binding site; other site 251229008681 Mg++ binding site; other site 251229008682 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 251229008683 putative trimer interface [polypeptide binding]; other site 251229008684 putative CoA binding site [chemical binding]; other site 251229008685 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 251229008686 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 251229008687 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 251229008688 G1 box; other site 251229008689 GTP/Mg2+ binding site [chemical binding]; other site 251229008690 Switch I region; other site 251229008691 G2 box; other site 251229008692 Switch II region; other site 251229008693 G3 box; other site 251229008694 G4 box; other site 251229008695 Domain of unknown function (DUF697); Region: DUF697; pfam05128 251229008696 Predicted esterase [General function prediction only]; Region: COG0400 251229008697 putative hydrolase; Provisional; Region: PRK11460 251229008698 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 251229008699 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 251229008700 Flavoprotein; Region: Flavoprotein; pfam02441 251229008701 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 251229008702 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251229008703 flavodoxin FldA; Validated; Region: PRK09267 251229008704 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 251229008705 Photosystem I reaction centre subunit XI; Region: PsaL; cl03651 251229008706 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 251229008707 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 251229008708 active site 251229008709 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 251229008710 Fe-S cluster binding site [ion binding]; other site 251229008711 active site 251229008712 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 251229008713 active site 251229008714 dimer interface [polypeptide binding]; other site 251229008715 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 251229008716 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 251229008717 active site 251229008718 HIGH motif; other site 251229008719 dimer interface [polypeptide binding]; other site 251229008720 KMSKS motif; other site 251229008721 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 251229008722 Transglycosylase; Region: Transgly; pfam00912 251229008723 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 251229008724 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 251229008725 Pirin-related protein [General function prediction only]; Region: COG1741 251229008726 Pirin; Region: Pirin; pfam02678 251229008727 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 251229008728 PLD-like domain; Region: PLDc_2; pfam13091 251229008729 putative active site [active] 251229008730 catalytic site [active] 251229008731 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 251229008732 PLD-like domain; Region: PLDc_2; pfam13091 251229008733 putative active site [active] 251229008734 catalytic site [active] 251229008735 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 251229008736 metal ion-dependent adhesion site (MIDAS); other site 251229008737 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 251229008738 MltA specific insert domain; Region: MltA; pfam03562 251229008739 3D domain; Region: 3D; pfam06725 251229008740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229008741 ATP binding site [chemical binding]; other site 251229008742 G-X-G motif; other site 251229008743 Biofilm formation and stress response factor; Region: BsmA; cl01794 251229008744 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 251229008745 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 251229008746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251229008747 ATP binding site [chemical binding]; other site 251229008748 putative Mg++ binding site [ion binding]; other site 251229008749 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251229008750 nucleotide binding region [chemical binding]; other site 251229008751 ATP-binding site [chemical binding]; other site 251229008752 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 251229008753 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 251229008754 Domain of unknown function DUF21; Region: DUF21; pfam01595 251229008755 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 251229008756 Transporter associated domain; Region: CorC_HlyC; smart01091 251229008757 glycogen synthase; Provisional; Region: glgA; PRK00654 251229008758 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 251229008759 ADP-binding pocket [chemical binding]; other site 251229008760 homodimer interface [polypeptide binding]; other site 251229008761 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 251229008762 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 251229008763 domain interfaces; other site 251229008764 active site 251229008765 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 251229008766 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 251229008767 putative active site [active] 251229008768 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 251229008769 putative active site [active] 251229008770 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 251229008771 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 251229008772 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 251229008773 catalytic triad [active] 251229008774 Type IV secretion system proteins; Region: T4SS; pfam07996 251229008775 cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153 251229008776 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 251229008777 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 251229008778 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 251229008779 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251229008780 active site 251229008781 catalytic tetrad [active] 251229008782 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 251229008783 toxin-antitoxin system, toxin component, Txe/YoeB family; Region: toxin_Txe_YoeB; TIGR02116 251229008784 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 251229008785 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 251229008786 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 251229008787 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 251229008788 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 251229008789 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 251229008790 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 251229008791 WYL domain; Region: WYL; pfam13280 251229008792 Transcriptional regulator; Region: Rrf2; pfam02082 251229008793 Predicted transcriptional regulator [Transcription]; Region: COG1959 251229008794 Response regulator receiver domain; Region: Response_reg; pfam00072 251229008795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229008796 active site 251229008797 phosphorylation site [posttranslational modification] 251229008798 intermolecular recognition site; other site 251229008799 dimerization interface [polypeptide binding]; other site 251229008800 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229008801 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229008802 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229008803 dimer interface [polypeptide binding]; other site 251229008804 phosphorylation site [posttranslational modification] 251229008805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229008806 ATP binding site [chemical binding]; other site 251229008807 Mg2+ binding site [ion binding]; other site 251229008808 G-X-G motif; other site 251229008809 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229008810 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229008811 active site 251229008812 ATP binding site [chemical binding]; other site 251229008813 substrate binding site [chemical binding]; other site 251229008814 activation loop (A-loop); other site 251229008815 AAA ATPase domain; Region: AAA_16; pfam13191 251229008816 Predicted ATPase [General function prediction only]; Region: COG3899 251229008817 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229008818 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229008819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229008820 dimer interface [polypeptide binding]; other site 251229008821 phosphorylation site [posttranslational modification] 251229008822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229008823 ATP binding site [chemical binding]; other site 251229008824 Mg2+ binding site [ion binding]; other site 251229008825 G-X-G motif; other site 251229008826 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229008827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229008828 active site 251229008829 phosphorylation site [posttranslational modification] 251229008830 intermolecular recognition site; other site 251229008831 dimerization interface [polypeptide binding]; other site 251229008832 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 251229008833 Mechanosensitive ion channel; Region: MS_channel; pfam00924 251229008834 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 251229008835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229008836 dimer interface [polypeptide binding]; other site 251229008837 phosphorylation site [posttranslational modification] 251229008838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229008839 ATP binding site [chemical binding]; other site 251229008840 Mg2+ binding site [ion binding]; other site 251229008841 G-X-G motif; other site 251229008842 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229008843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229008844 active site 251229008845 phosphorylation site [posttranslational modification] 251229008846 intermolecular recognition site; other site 251229008847 dimerization interface [polypeptide binding]; other site 251229008848 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229008849 DNA binding site [nucleotide binding] 251229008850 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 251229008851 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251229008852 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 251229008853 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229008854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 251229008855 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 251229008856 dimerization interface [polypeptide binding]; other site 251229008857 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 251229008858 DNA binding residues [nucleotide binding] 251229008859 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 251229008860 dimer interface [polypeptide binding]; other site 251229008861 metal binding site [ion binding]; metal-binding site 251229008862 Phosphotransferase enzyme family; Region: APH; pfam01636 251229008863 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 251229008864 active site 251229008865 ATP binding site [chemical binding]; other site 251229008866 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 251229008867 substrate binding site [chemical binding]; other site 251229008868 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 251229008869 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 251229008870 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 251229008871 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 251229008872 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 251229008873 ligand binding site [chemical binding]; other site 251229008874 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 251229008875 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 251229008876 TrkA-N domain; Region: TrkA_N; pfam02254 251229008877 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 251229008878 heme bH binding site [chemical binding]; other site 251229008879 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 251229008880 intrachain domain interface; other site 251229008881 heme bL binding site [chemical binding]; other site 251229008882 interchain domain interface [polypeptide binding]; other site 251229008883 Qo binding site; other site 251229008884 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 251229008885 PGAP1-like protein; Region: PGAP1; pfam07819 251229008886 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 251229008887 active site 251229008888 SAM binding site [chemical binding]; other site 251229008889 homodimer interface [polypeptide binding]; other site 251229008890 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229008891 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229008892 PAS fold; Region: PAS_4; pfam08448 251229008893 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229008894 putative active site [active] 251229008895 heme pocket [chemical binding]; other site 251229008896 PAS domain; Region: PAS; smart00091 251229008897 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251229008898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229008899 dimer interface [polypeptide binding]; other site 251229008900 phosphorylation site [posttranslational modification] 251229008901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229008902 ATP binding site [chemical binding]; other site 251229008903 Mg2+ binding site [ion binding]; other site 251229008904 G-X-G motif; other site 251229008905 Response regulator receiver domain; Region: Response_reg; pfam00072 251229008906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229008907 active site 251229008908 phosphorylation site [posttranslational modification] 251229008909 intermolecular recognition site; other site 251229008910 dimerization interface [polypeptide binding]; other site 251229008911 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251229008912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229008913 active site 251229008914 phosphorylation site [posttranslational modification] 251229008915 intermolecular recognition site; other site 251229008916 dimerization interface [polypeptide binding]; other site 251229008917 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251229008918 DNA binding residues [nucleotide binding] 251229008919 dimerization interface [polypeptide binding]; other site 251229008920 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 251229008921 nucleoside/Zn binding site; other site 251229008922 dimer interface [polypeptide binding]; other site 251229008923 catalytic motif [active] 251229008924 Ion channel; Region: Ion_trans_2; pfam07885 251229008925 Double zinc ribbon; Region: DZR; pfam12773 251229008926 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 251229008927 GAF domain; Region: GAF; pfam01590 251229008928 GAF domain; Region: GAF_2; pfam13185 251229008929 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 251229008930 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 251229008931 active site 251229008932 dimer interface [polypeptide binding]; other site 251229008933 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 251229008934 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 251229008935 active site 251229008936 FMN binding site [chemical binding]; other site 251229008937 substrate binding site [chemical binding]; other site 251229008938 3Fe-4S cluster binding site [ion binding]; other site 251229008939 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 251229008940 domain interface; other site 251229008941 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 251229008942 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229008943 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 251229008944 classical (c) SDRs; Region: SDR_c; cd05233 251229008945 NAD(P) binding site [chemical binding]; other site 251229008946 active site 251229008947 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229008948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229008949 S-adenosylmethionine binding site [chemical binding]; other site 251229008950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 251229008951 Coenzyme A binding pocket [chemical binding]; other site 251229008952 KTSC domain; Region: KTSC; pfam13619 251229008953 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 251229008954 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 251229008955 dimer interface [polypeptide binding]; other site 251229008956 tetramer interface [polypeptide binding]; other site 251229008957 PYR/PP interface [polypeptide binding]; other site 251229008958 TPP binding site [chemical binding]; other site 251229008959 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 251229008960 TPP-binding site; other site 251229008961 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 251229008962 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 251229008963 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 251229008964 chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994 251229008965 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 251229008966 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 251229008967 dimer interface [polypeptide binding]; other site 251229008968 active site 251229008969 glycine-pyridoxal phosphate binding site [chemical binding]; other site 251229008970 folate binding site [chemical binding]; other site 251229008971 competence damage-inducible protein A; Provisional; Region: PRK00549 251229008972 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 251229008973 putative MPT binding site; other site 251229008974 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 251229008975 Dehydroquinase class II; Region: DHquinase_II; pfam01220 251229008976 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 251229008977 trimer interface [polypeptide binding]; other site 251229008978 active site 251229008979 dimer interface [polypeptide binding]; other site 251229008980 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 251229008981 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 251229008982 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 251229008983 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 251229008984 Zn2+ binding site [ion binding]; other site 251229008985 Mg2+ binding site [ion binding]; other site 251229008986 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 251229008987 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 251229008988 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 251229008989 Inward rectifier potassium channel; Region: IRK; pfam01007 251229008990 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 251229008991 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 251229008992 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229008993 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229008994 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 251229008995 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 251229008996 NADP binding site [chemical binding]; other site 251229008997 active site 251229008998 putative substrate binding site [chemical binding]; other site 251229008999 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 251229009000 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 251229009001 NADP-binding site; other site 251229009002 homotetramer interface [polypeptide binding]; other site 251229009003 substrate binding site [chemical binding]; other site 251229009004 homodimer interface [polypeptide binding]; other site 251229009005 active site 251229009006 Bacterial sugar transferase; Region: Bac_transf; pfam02397 251229009007 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229009008 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 251229009009 putative ADP-binding pocket [chemical binding]; other site 251229009010 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251229009011 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 251229009012 putative NAD(P) binding site [chemical binding]; other site 251229009013 active site 251229009014 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 251229009015 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 251229009016 Bacterial sugar transferase; Region: Bac_transf; pfam02397 251229009017 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229009018 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229009019 Predicted membrane protein [Function unknown]; Region: COG3463 251229009020 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 251229009021 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 251229009022 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 251229009023 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229009024 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229009025 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 251229009026 C-terminal peptidase (prc); Region: prc; TIGR00225 251229009027 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 251229009028 protein binding site [polypeptide binding]; other site 251229009029 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 251229009030 Catalytic dyad [active] 251229009031 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 251229009032 DHH family; Region: DHH; pfam01368 251229009033 DHHA1 domain; Region: DHHA1; pfam02272 251229009034 Response regulator receiver domain; Region: Response_reg; pfam00072 251229009035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229009036 active site 251229009037 phosphorylation site [posttranslational modification] 251229009038 intermolecular recognition site; other site 251229009039 dimerization interface [polypeptide binding]; other site 251229009040 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 251229009041 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229009042 Zn binding site [ion binding]; other site 251229009043 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 251229009044 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229009045 active site 251229009046 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 251229009047 aromatic arch; other site 251229009048 DCoH dimer interaction site [polypeptide binding]; other site 251229009049 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 251229009050 DCoH tetramer interaction site [polypeptide binding]; other site 251229009051 substrate binding site [chemical binding]; other site 251229009052 Transcriptional regulators [Transcription]; Region: PurR; COG1609 251229009053 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 251229009054 DNA binding site [nucleotide binding] 251229009055 domain linker motif; other site 251229009056 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 251229009057 putative dimerization interface [polypeptide binding]; other site 251229009058 putative ligand binding site [chemical binding]; other site 251229009059 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251229009060 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251229009061 ligand binding site [chemical binding]; other site 251229009062 flexible hinge region; other site 251229009063 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 251229009064 trimer interface [polypeptide binding]; other site 251229009065 putative Zn binding site [ion binding]; other site 251229009066 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 251229009067 Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480 251229009068 Pheophorbide a oxygenase; Region: PaO; pfam08417 251229009069 OstA-like protein; Region: OstA; cl00844 251229009070 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 251229009071 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 251229009072 Walker A/P-loop; other site 251229009073 ATP binding site [chemical binding]; other site 251229009074 Q-loop/lid; other site 251229009075 ABC transporter signature motif; other site 251229009076 Walker B; other site 251229009077 D-loop; other site 251229009078 H-loop/switch region; other site 251229009079 Predicted permeases [General function prediction only]; Region: COG0795 251229009080 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 251229009081 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 251229009082 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 251229009083 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229009084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229009085 active site 251229009086 phosphorylation site [posttranslational modification] 251229009087 intermolecular recognition site; other site 251229009088 dimerization interface [polypeptide binding]; other site 251229009089 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229009090 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251229009091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229009092 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 251229009093 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 251229009094 PYR/PP interface [polypeptide binding]; other site 251229009095 dimer interface [polypeptide binding]; other site 251229009096 TPP binding site [chemical binding]; other site 251229009097 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 251229009098 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 251229009099 TPP-binding site [chemical binding]; other site 251229009100 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 251229009101 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 251229009102 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 251229009103 NAD binding site [chemical binding]; other site 251229009104 Phe binding site; other site 251229009105 Uncharacterized conserved protein [Function unknown]; Region: COG3391 251229009106 NHL repeat; Region: NHL; pfam01436 251229009107 NHL repeat; Region: NHL; pfam01436 251229009108 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 251229009109 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 251229009110 active site 251229009111 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; COG0382 251229009112 UbiA prenyltransferase family; Region: UbiA; pfam01040 251229009113 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 251229009114 prephenate dehydrogenase; Provisional; Region: PRK06444 251229009115 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 251229009116 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 251229009117 catalytic residues [active] 251229009118 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 251229009119 active site 251229009120 metal binding site [ion binding]; metal-binding site 251229009121 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 251229009122 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 251229009123 putative C-terminal domain interface [polypeptide binding]; other site 251229009124 putative GSH binding site (G-site) [chemical binding]; other site 251229009125 putative dimer interface [polypeptide binding]; other site 251229009126 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 251229009127 N-terminal domain interface [polypeptide binding]; other site 251229009128 Uncharacterized conserved protein [Function unknown]; Region: COG3379 251229009129 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 251229009130 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 251229009131 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 251229009132 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229009133 UDP-galactopyranose mutase; Region: GLF; pfam03275 251229009134 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 251229009135 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229009136 active site 251229009137 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 251229009138 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229009139 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229009140 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 251229009141 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 251229009142 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 251229009143 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 251229009144 Walker A/P-loop; other site 251229009145 ATP binding site [chemical binding]; other site 251229009146 Q-loop/lid; other site 251229009147 ABC transporter signature motif; other site 251229009148 Walker B; other site 251229009149 D-loop; other site 251229009150 H-loop/switch region; other site 251229009151 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 251229009152 putative carbohydrate binding site [chemical binding]; other site 251229009153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229009154 S-adenosylmethionine binding site [chemical binding]; other site 251229009155 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 251229009156 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 251229009157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229009158 Coenzyme A binding pocket [chemical binding]; other site 251229009159 anthranilate synthase; Provisional; Region: PRK13566 251229009160 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 251229009161 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 251229009162 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 251229009163 glutamine binding [chemical binding]; other site 251229009164 catalytic triad [active] 251229009165 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 251229009166 active site 251229009167 ribulose/triose binding site [chemical binding]; other site 251229009168 phosphate binding site [ion binding]; other site 251229009169 substrate (anthranilate) binding pocket [chemical binding]; other site 251229009170 product (indole) binding pocket [chemical binding]; other site 251229009171 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 251229009172 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 251229009173 substrate binding site [chemical binding]; other site 251229009174 active site 251229009175 catalytic residues [active] 251229009176 heterodimer interface [polypeptide binding]; other site 251229009177 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 251229009178 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 251229009179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229009180 catalytic residue [active] 251229009181 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 251229009182 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 251229009183 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 251229009184 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 251229009185 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 251229009186 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 251229009187 putative [4Fe-4S] binding site [ion binding]; other site 251229009188 putative molybdopterin cofactor binding site [chemical binding]; other site 251229009189 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 251229009190 molybdopterin cofactor binding site; other site 251229009191 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 251229009192 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 251229009193 active site 251229009194 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 251229009195 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 251229009196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 251229009197 Protein of unknown function (DUF433); Region: DUF433; cl01030 251229009198 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 251229009199 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 251229009200 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 251229009201 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 251229009202 endonuclease III; Region: ENDO3c; smart00478 251229009203 minor groove reading motif; other site 251229009204 helix-hairpin-helix signature motif; other site 251229009205 substrate binding pocket [chemical binding]; other site 251229009206 active site 251229009207 prolyl-tRNA synthetase; Provisional; Region: PRK08661 251229009208 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 251229009209 dimer interface [polypeptide binding]; other site 251229009210 motif 1; other site 251229009211 active site 251229009212 motif 2; other site 251229009213 motif 3; other site 251229009214 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 251229009215 anticodon binding site; other site 251229009216 zinc-binding site [ion binding]; other site 251229009217 phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418 251229009218 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 251229009219 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 251229009220 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 251229009221 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 251229009222 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 251229009223 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 251229009224 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 251229009225 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 251229009226 RNA binding site [nucleotide binding]; other site 251229009227 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 251229009228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229009229 Coenzyme A binding pocket [chemical binding]; other site 251229009230 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 251229009231 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 251229009232 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 251229009233 substrate-cofactor binding pocket; other site 251229009234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229009235 catalytic residue [active] 251229009236 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 251229009237 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 251229009238 P-loop; other site 251229009239 Magnesium ion binding site [ion binding]; other site 251229009240 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 251229009241 Magnesium ion binding site [ion binding]; other site 251229009242 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251229009243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229009244 active site 251229009245 phosphorylation site [posttranslational modification] 251229009246 intermolecular recognition site; other site 251229009247 dimerization interface [polypeptide binding]; other site 251229009248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251229009249 DNA binding residues [nucleotide binding] 251229009250 dimerization interface [polypeptide binding]; other site 251229009251 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229009252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229009253 dimer interface [polypeptide binding]; other site 251229009254 phosphorylation site [posttranslational modification] 251229009255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229009256 ATP binding site [chemical binding]; other site 251229009257 Mg2+ binding site [ion binding]; other site 251229009258 G-X-G motif; other site 251229009259 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 251229009260 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 251229009261 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 251229009262 Soluble P-type ATPase [General function prediction only]; Region: COG4087 251229009263 K+-transporting ATPase, c chain; Region: KdpC; cl00944 251229009264 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 251229009265 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 251229009266 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 251229009267 Ligand Binding Site [chemical binding]; other site 251229009268 Uncharacterized conserved protein [Function unknown]; Region: COG0327 251229009269 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 251229009270 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 251229009271 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 251229009272 Walker A motif; other site 251229009273 ATP binding site [chemical binding]; other site 251229009274 Walker B motif; other site 251229009275 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 251229009276 glycogen synthase; Provisional; Region: glgA; PRK00654 251229009277 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 251229009278 ADP-binding pocket [chemical binding]; other site 251229009279 homodimer interface [polypeptide binding]; other site 251229009280 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 251229009281 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 251229009282 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 251229009283 active site 251229009284 homodimer interface [polypeptide binding]; other site 251229009285 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 251229009286 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 251229009287 Walker A motif; other site 251229009288 ATP binding site [chemical binding]; other site 251229009289 Walker B motif; other site 251229009290 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 251229009291 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 251229009292 tetramer interface [polypeptide binding]; other site 251229009293 dimer interface [polypeptide binding]; other site 251229009294 ABC-2 type transporter; Region: ABC2_membrane; cl17235 251229009295 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 251229009296 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 251229009297 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 251229009298 Double zinc ribbon; Region: DZR; pfam12773 251229009299 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 251229009300 hypothetical protein; Provisional; Region: PRK06208 251229009301 intersubunit interface [polypeptide binding]; other site 251229009302 active site 251229009303 Zn2+ binding site [ion binding]; other site 251229009304 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 251229009305 GAF domain; Region: GAF; cl17456 251229009306 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251229009307 DNA binding residues [nucleotide binding] 251229009308 dimerization interface [polypeptide binding]; other site 251229009309 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 251229009310 Putative phosphatase (DUF442); Region: DUF442; cl17385 251229009311 magnesium chelatase subunit H; Provisional; Region: PLN03241 251229009312 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 251229009313 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 251229009314 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 251229009315 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 251229009316 active site 251229009317 catalytic site [active] 251229009318 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 251229009319 calcium/proton exchanger (cax); Region: cax; TIGR00378 251229009320 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 251229009321 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 251229009322 calcium/proton exchanger (cax); Region: cax; TIGR00378 251229009323 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 251229009324 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 251229009325 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 251229009326 heme-binding site [chemical binding]; other site 251229009327 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 251229009328 pyruvate kinase; Provisional; Region: PRK06354 251229009329 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 251229009330 domain interfaces; other site 251229009331 active site 251229009332 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 251229009333 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 251229009334 Fatty acid desaturase; Region: FA_desaturase; pfam00487 251229009335 putative di-iron ligands [ion binding]; other site 251229009336 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 251229009337 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 251229009338 Peptidase family M50; Region: Peptidase_M50; pfam02163 251229009339 active site 251229009340 putative substrate binding region [chemical binding]; other site 251229009341 Glucose inhibited division protein A; Region: GIDA; pfam01134 251229009342 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 251229009343 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 251229009344 Histidine kinase; Region: HisKA_3; pfam07730 251229009345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229009346 ATP binding site [chemical binding]; other site 251229009347 Mg2+ binding site [ion binding]; other site 251229009348 G-X-G motif; other site 251229009349 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251229009350 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 251229009351 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229009352 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251229009353 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 251229009354 FtsX-like permease family; Region: FtsX; pfam02687 251229009355 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229009356 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251229009357 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229009358 SnoaL-like domain; Region: SnoaL_2; pfam12680 251229009359 Uncharacterized conserved protein [Function unknown]; Region: COG3268 251229009360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229009361 NAD(P) binding site [chemical binding]; other site 251229009362 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229009363 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229009364 active site 251229009365 ATP binding site [chemical binding]; other site 251229009366 substrate binding site [chemical binding]; other site 251229009367 activation loop (A-loop); other site 251229009368 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229009369 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229009370 structural tetrad; other site 251229009371 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 251229009372 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229009373 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229009374 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 251229009375 classical (c) SDRs; Region: SDR_c; cd05233 251229009376 NAD(P) binding site [chemical binding]; other site 251229009377 active site 251229009378 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 251229009379 nucleotide binding site [chemical binding]; other site 251229009380 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 251229009381 nucleotide binding site [chemical binding]; other site 251229009382 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 251229009383 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 251229009384 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 251229009385 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 251229009386 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 251229009387 putative acyl-acceptor binding pocket; other site 251229009388 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 251229009389 Acyltransferase family; Region: Acyl_transf_3; pfam01757 251229009390 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229009391 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229009392 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229009393 dimer interface [polypeptide binding]; other site 251229009394 phosphorylation site [posttranslational modification] 251229009395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229009396 ATP binding site [chemical binding]; other site 251229009397 Mg2+ binding site [ion binding]; other site 251229009398 G-X-G motif; other site 251229009399 Ferredoxin [Energy production and conversion]; Region: COG1146 251229009400 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 251229009401 Ceramidase; Region: Ceramidase; pfam05875 251229009402 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 251229009403 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 251229009404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229009405 active site 251229009406 phosphorylation site [posttranslational modification] 251229009407 intermolecular recognition site; other site 251229009408 dimerization interface [polypeptide binding]; other site 251229009409 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229009410 GAF domain; Region: GAF; pfam01590 251229009411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229009412 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 251229009413 putative active site [active] 251229009414 heme pocket [chemical binding]; other site 251229009415 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229009416 putative active site [active] 251229009417 heme pocket [chemical binding]; other site 251229009418 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229009419 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229009420 PAS domain S-box; Region: sensory_box; TIGR00229 251229009421 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229009422 putative active site [active] 251229009423 heme pocket [chemical binding]; other site 251229009424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229009425 dimer interface [polypeptide binding]; other site 251229009426 phosphorylation site [posttranslational modification] 251229009427 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 251229009428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229009429 ATP binding site [chemical binding]; other site 251229009430 G-X-G motif; other site 251229009431 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229009432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229009433 active site 251229009434 phosphorylation site [posttranslational modification] 251229009435 intermolecular recognition site; other site 251229009436 dimerization interface [polypeptide binding]; other site 251229009437 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229009438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229009439 active site 251229009440 phosphorylation site [posttranslational modification] 251229009441 intermolecular recognition site; other site 251229009442 dimerization interface [polypeptide binding]; other site 251229009443 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229009444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229009445 active site 251229009446 phosphorylation site [posttranslational modification] 251229009447 intermolecular recognition site; other site 251229009448 dimerization interface [polypeptide binding]; other site 251229009449 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229009450 DNA binding site [nucleotide binding] 251229009451 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 251229009452 putative binding surface; other site 251229009453 active site 251229009454 Response regulator receiver domain; Region: Response_reg; pfam00072 251229009455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229009456 active site 251229009457 phosphorylation site [posttranslational modification] 251229009458 intermolecular recognition site; other site 251229009459 dimerization interface [polypeptide binding]; other site 251229009460 Response regulator receiver domain; Region: Response_reg; pfam00072 251229009461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229009462 active site 251229009463 phosphorylation site [posttranslational modification] 251229009464 intermolecular recognition site; other site 251229009465 dimerization interface [polypeptide binding]; other site 251229009466 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229009467 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229009468 metal binding site [ion binding]; metal-binding site 251229009469 active site 251229009470 I-site; other site 251229009471 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 251229009472 Fatty acid desaturase; Region: FA_desaturase; pfam00487 251229009473 putative di-iron ligands [ion binding]; other site 251229009474 ParB-like nuclease domain; Region: ParB; smart00470 251229009475 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 251229009476 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 251229009477 non-specific DNA binding site [nucleotide binding]; other site 251229009478 salt bridge; other site 251229009479 sequence-specific DNA binding site [nucleotide binding]; other site 251229009480 Homeodomain-like domain; Region: HTH_23; pfam13384 251229009481 Winged helix-turn helix; Region: HTH_29; pfam13551 251229009482 Winged helix-turn helix; Region: HTH_33; pfam13592 251229009483 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251229009484 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251229009485 ligand binding site [chemical binding]; other site 251229009486 flexible hinge region; other site 251229009487 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 251229009488 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 251229009489 putative active site [active] 251229009490 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229009491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229009492 Walker A/P-loop; other site 251229009493 ATP binding site [chemical binding]; other site 251229009494 Q-loop/lid; other site 251229009495 ABC transporter signature motif; other site 251229009496 Walker B; other site 251229009497 D-loop; other site 251229009498 H-loop/switch region; other site 251229009499 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 251229009500 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 251229009501 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229009502 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 251229009503 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 251229009504 Phosphotransferase enzyme family; Region: APH; pfam01636 251229009505 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 251229009506 active site 251229009507 ATP binding site [chemical binding]; other site 251229009508 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 251229009509 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 251229009510 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 251229009511 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 251229009512 Response regulator receiver domain; Region: Response_reg; pfam00072 251229009513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229009514 active site 251229009515 phosphorylation site [posttranslational modification] 251229009516 intermolecular recognition site; other site 251229009517 dimerization interface [polypeptide binding]; other site 251229009518 PAS domain S-box; Region: sensory_box; TIGR00229 251229009519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229009520 putative active site [active] 251229009521 heme pocket [chemical binding]; other site 251229009522 PAS domain S-box; Region: sensory_box; TIGR00229 251229009523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229009524 putative active site [active] 251229009525 heme pocket [chemical binding]; other site 251229009526 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229009527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229009528 dimer interface [polypeptide binding]; other site 251229009529 phosphorylation site [posttranslational modification] 251229009530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229009531 ATP binding site [chemical binding]; other site 251229009532 Mg2+ binding site [ion binding]; other site 251229009533 G-X-G motif; other site 251229009534 Response regulator receiver domain; Region: Response_reg; pfam00072 251229009535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229009536 active site 251229009537 phosphorylation site [posttranslational modification] 251229009538 intermolecular recognition site; other site 251229009539 dimerization interface [polypeptide binding]; other site 251229009540 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 251229009541 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 251229009542 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 251229009543 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 251229009544 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 251229009545 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 251229009546 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 251229009547 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 251229009548 catalytic core [active] 251229009549 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 251229009550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229009551 dimer interface [polypeptide binding]; other site 251229009552 conserved gate region; other site 251229009553 putative PBP binding loops; other site 251229009554 ABC-ATPase subunit interface; other site 251229009555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 251229009556 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 251229009557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229009558 ATP binding site [chemical binding]; other site 251229009559 Walker A/P-loop; other site 251229009560 Q-loop/lid; other site 251229009561 ABC transporter signature motif; other site 251229009562 Walker B; other site 251229009563 D-loop; other site 251229009564 H-loop/switch region; other site 251229009565 TOBE domain; Region: TOBE_2; pfam08402 251229009566 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 251229009567 multiple promoter invertase; Provisional; Region: mpi; PRK13413 251229009568 catalytic residues [active] 251229009569 catalytic nucleophile [active] 251229009570 Presynaptic Site I dimer interface [polypeptide binding]; other site 251229009571 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 251229009572 Synaptic Flat tetramer interface [polypeptide binding]; other site 251229009573 Synaptic Site I dimer interface [polypeptide binding]; other site 251229009574 DNA binding site [nucleotide binding] 251229009575 Homeodomain-like domain; Region: HTH_23; pfam13384 251229009576 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 251229009577 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 251229009578 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 251229009579 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251229009580 active site 251229009581 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 251229009582 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 251229009583 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 251229009584 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 251229009585 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 251229009586 short chain dehydrogenase; Provisional; Region: PRK06172 251229009587 classical (c) SDRs; Region: SDR_c; cd05233 251229009588 NAD(P) binding site [chemical binding]; other site 251229009589 active site 251229009590 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 251229009591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229009592 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 251229009593 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 251229009594 potential catalytic triad [active] 251229009595 conserved cys residue [active] 251229009596 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 251229009597 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229009598 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 251229009599 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 251229009600 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 251229009601 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251229009602 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 251229009603 E3 interaction surface; other site 251229009604 lipoyl attachment site [posttranslational modification]; other site 251229009605 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229009606 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 251229009607 Protein export membrane protein; Region: SecD_SecF; cl14618 251229009608 GUN4-like; Region: GUN4; pfam05419 251229009609 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 251229009610 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 251229009611 active site clefts [active] 251229009612 zinc binding site [ion binding]; other site 251229009613 dimer interface [polypeptide binding]; other site 251229009614 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 251229009615 Putative mono-oxygenase ydhR; Region: ydhR; cl07420 251229009616 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 251229009617 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229009618 AAA ATPase domain; Region: AAA_16; pfam13191 251229009619 Walker A motif; other site 251229009620 ATP binding site [chemical binding]; other site 251229009621 Walker B motif; other site 251229009622 WD domain, G-beta repeat; Region: WD40; pfam00400 251229009623 WD40 repeats; Region: WD40; smart00320 251229009624 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229009625 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229009626 structural tetrad; other site 251229009627 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229009628 structural tetrad; other site 251229009629 AAA ATPase domain; Region: AAA_16; pfam13191 251229009630 NACHT domain; Region: NACHT; pfam05729 251229009631 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229009632 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229009633 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229009634 structural tetrad; other site 251229009635 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229009636 structural tetrad; other site 251229009637 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229009638 glyoxylate reductase; Reviewed; Region: PRK13243 251229009639 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 251229009640 dimerization interface [polypeptide binding]; other site 251229009641 ligand binding site [chemical binding]; other site 251229009642 NADP binding site [chemical binding]; other site 251229009643 catalytic site [active] 251229009644 acetate--CoA ligase; Provisional; Region: PLN03052 251229009645 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 251229009646 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 251229009647 acyl-activating enzyme (AAE) consensus motif; other site 251229009648 AMP binding site [chemical binding]; other site 251229009649 active site 251229009650 CoA binding site [chemical binding]; other site 251229009651 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 251229009652 UbiA prenyltransferase family; Region: UbiA; pfam01040 251229009653 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 251229009654 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 251229009655 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 251229009656 dimer interface [polypeptide binding]; other site 251229009657 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 251229009658 active site 251229009659 Fe binding site [ion binding]; other site 251229009660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229009661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229009662 dimer interface [polypeptide binding]; other site 251229009663 phosphorylation site [posttranslational modification] 251229009664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229009665 ATP binding site [chemical binding]; other site 251229009666 Mg2+ binding site [ion binding]; other site 251229009667 G-X-G motif; other site 251229009668 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229009669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229009670 active site 251229009671 phosphorylation site [posttranslational modification] 251229009672 intermolecular recognition site; other site 251229009673 dimerization interface [polypeptide binding]; other site 251229009674 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229009675 DNA binding site [nucleotide binding] 251229009676 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 251229009677 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 251229009678 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 251229009679 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 251229009680 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 251229009681 active site 251229009682 phosphodiesterase YaeI; Provisional; Region: PRK11340 251229009683 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 251229009684 putative active site [active] 251229009685 putative metal binding site [ion binding]; other site 251229009686 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 251229009687 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 251229009688 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 251229009689 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 251229009690 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 251229009691 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 251229009692 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 251229009693 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 251229009694 putative active site [active] 251229009695 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229009696 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229009697 Walker A/P-loop; other site 251229009698 ATP binding site [chemical binding]; other site 251229009699 Q-loop/lid; other site 251229009700 ABC transporter signature motif; other site 251229009701 Walker B; other site 251229009702 D-loop; other site 251229009703 H-loop/switch region; other site 251229009704 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 251229009705 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229009706 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251229009707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229009708 active site 251229009709 phosphorylation site [posttranslational modification] 251229009710 intermolecular recognition site; other site 251229009711 dimerization interface [polypeptide binding]; other site 251229009712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251229009713 DNA binding residues [nucleotide binding] 251229009714 dimerization interface [polypeptide binding]; other site 251229009715 Restriction endonuclease; Region: Mrr_cat; pfam04471 251229009716 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 251229009717 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 251229009718 P-loop; other site 251229009719 Magnesium ion binding site [ion binding]; other site 251229009720 Uncharacterized conserved protein [Function unknown]; Region: COG4095 251229009721 Transmembrane proteins 14C; Region: Tmemb_14; cl02346 251229009722 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 251229009723 dimer interface [polypeptide binding]; other site 251229009724 [2Fe-2S] cluster binding site [ion binding]; other site 251229009725 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 251229009726 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 251229009727 dimerization interface [polypeptide binding]; other site 251229009728 DPS ferroxidase diiron center [ion binding]; other site 251229009729 ion pore; other site 251229009730 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 251229009731 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 251229009732 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251229009733 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 251229009734 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251229009735 DNA binding residues [nucleotide binding] 251229009736 Protein of unknown function (DUF760); Region: DUF760; pfam05542 251229009737 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 251229009738 active site 251229009739 8-oxo-dGMP binding site [chemical binding]; other site 251229009740 nudix motif; other site 251229009741 metal binding site [ion binding]; metal-binding site 251229009742 adaptive-response sensory kinase; Validated; Region: PRK09303 251229009743 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 251229009744 tetramer interface [polypeptide binding]; other site 251229009745 dimer interface [polypeptide binding]; other site 251229009746 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229009747 dimer interface [polypeptide binding]; other site 251229009748 phosphorylation site [posttranslational modification] 251229009749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229009750 ATP binding site [chemical binding]; other site 251229009751 Mg2+ binding site [ion binding]; other site 251229009752 G-X-G motif; other site 251229009753 S-layer homology domain; Region: SLH; pfam00395 251229009754 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 251229009755 putative catalytic residue [active] 251229009756 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 251229009757 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229009758 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229009759 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 251229009760 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 251229009761 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 251229009762 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 251229009763 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 251229009764 sulfate transport protein; Provisional; Region: cysT; CHL00187 251229009765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229009766 dimer interface [polypeptide binding]; other site 251229009767 conserved gate region; other site 251229009768 putative PBP binding loops; other site 251229009769 ABC-ATPase subunit interface; other site 251229009770 sulfate transport protein; Provisional; Region: cysT; CHL00187 251229009771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229009772 dimer interface [polypeptide binding]; other site 251229009773 conserved gate region; other site 251229009774 putative PBP binding loops; other site 251229009775 ABC-ATPase subunit interface; other site 251229009776 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 251229009777 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 251229009778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229009779 dimer interface [polypeptide binding]; other site 251229009780 conserved gate region; other site 251229009781 putative PBP binding loops; other site 251229009782 ABC-ATPase subunit interface; other site 251229009783 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 251229009784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229009785 putative active site [active] 251229009786 heme pocket [chemical binding]; other site 251229009787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229009788 dimer interface [polypeptide binding]; other site 251229009789 phosphorylation site [posttranslational modification] 251229009790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229009791 ATP binding site [chemical binding]; other site 251229009792 Mg2+ binding site [ion binding]; other site 251229009793 G-X-G motif; other site 251229009794 Response regulator receiver domain; Region: Response_reg; pfam00072 251229009795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229009796 active site 251229009797 phosphorylation site [posttranslational modification] 251229009798 intermolecular recognition site; other site 251229009799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229009800 PAS fold; Region: PAS_3; pfam08447 251229009801 putative active site [active] 251229009802 heme pocket [chemical binding]; other site 251229009803 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229009804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229009805 dimer interface [polypeptide binding]; other site 251229009806 phosphorylation site [posttranslational modification] 251229009807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229009808 ATP binding site [chemical binding]; other site 251229009809 Mg2+ binding site [ion binding]; other site 251229009810 G-X-G motif; other site 251229009811 Response regulator receiver domain; Region: Response_reg; pfam00072 251229009812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229009813 active site 251229009814 phosphorylation site [posttranslational modification] 251229009815 intermolecular recognition site; other site 251229009816 dimerization interface [polypeptide binding]; other site 251229009817 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 251229009818 Glycoprotease family; Region: Peptidase_M22; pfam00814 251229009819 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 251229009820 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 251229009821 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 251229009822 active site 251229009823 NTP binding site [chemical binding]; other site 251229009824 metal binding triad [ion binding]; metal-binding site 251229009825 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 251229009826 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 251229009827 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 251229009828 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 251229009829 proposed catalytic triad [active] 251229009830 active site nucleophile [active] 251229009831 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 251229009832 ATP-grasp domain; Region: ATP-grasp_4; cl17255 251229009833 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 251229009834 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 251229009835 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 251229009836 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229009837 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229009838 active site 251229009839 ATP binding site [chemical binding]; other site 251229009840 substrate binding site [chemical binding]; other site 251229009841 activation loop (A-loop); other site 251229009842 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 251229009843 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 251229009844 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251229009845 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 251229009846 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251229009847 DNA binding residues [nucleotide binding] 251229009848 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 251229009849 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251229009850 ATP binding site [chemical binding]; other site 251229009851 putative Mg++ binding site [ion binding]; other site 251229009852 helicase superfamily c-terminal domain; Region: HELICc; smart00490 251229009853 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 251229009854 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229009855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229009856 dimer interface [polypeptide binding]; other site 251229009857 phosphorylation site [posttranslational modification] 251229009858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229009859 ATP binding site [chemical binding]; other site 251229009860 Mg2+ binding site [ion binding]; other site 251229009861 G-X-G motif; other site 251229009862 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229009863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229009864 active site 251229009865 phosphorylation site [posttranslational modification] 251229009866 intermolecular recognition site; other site 251229009867 dimerization interface [polypeptide binding]; other site 251229009868 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229009869 DNA binding site [nucleotide binding] 251229009870 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 251229009871 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 251229009872 Walker A/P-loop; other site 251229009873 ATP binding site [chemical binding]; other site 251229009874 Q-loop/lid; other site 251229009875 ABC transporter signature motif; other site 251229009876 Walker B; other site 251229009877 D-loop; other site 251229009878 H-loop/switch region; other site 251229009879 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 251229009880 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 251229009881 Walker A/P-loop; other site 251229009882 ATP binding site [chemical binding]; other site 251229009883 Q-loop/lid; other site 251229009884 ABC transporter signature motif; other site 251229009885 Walker B; other site 251229009886 D-loop; other site 251229009887 H-loop/switch region; other site 251229009888 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 251229009889 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 251229009890 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 251229009891 dimer interface [polypeptide binding]; other site 251229009892 ssDNA binding site [nucleotide binding]; other site 251229009893 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 251229009894 tetramer (dimer of dimers) interface [polypeptide binding]; other site 251229009895 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 251229009896 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 251229009897 active site 251229009898 Substrate binding site; other site 251229009899 Mg++ binding site; other site 251229009900 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 251229009901 putative trimer interface [polypeptide binding]; other site 251229009902 putative CoA binding site [chemical binding]; other site 251229009903 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 251229009904 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 251229009905 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 251229009906 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 251229009907 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251229009908 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 251229009909 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 251229009910 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 251229009911 PemK-like protein; Region: PemK; pfam02452 251229009912 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 251229009913 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 251229009914 putative active site [active] 251229009915 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 251229009916 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 251229009917 active site 251229009918 DNA binding site [nucleotide binding] 251229009919 Int/Topo IB signature motif; other site 251229009920 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 251229009921 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 251229009922 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 251229009923 active site 251229009924 DNA binding site [nucleotide binding] 251229009925 Int/Topo IB signature motif; other site 251229009926 Protein of unknown function DUF99; Region: DUF99; pfam01949 251229009927 hypothetical protein; Provisional; Region: PRK00766 251229009928 Protein of unknown function (DUF998); Region: DUF998; pfam06197 251229009929 XisI protein; Region: XisI; pfam08869 251229009930 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 251229009931 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 251229009932 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 251229009933 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 251229009934 catalytic residue [active] 251229009935 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 251229009936 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 251229009937 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 251229009938 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 251229009939 RNA binding surface [nucleotide binding]; other site 251229009940 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 251229009941 active site 251229009942 Phycobilisome protein; Region: Phycobilisome; cl08227 251229009943 Phycobilisome protein; Region: Phycobilisome; cl08227 251229009944 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251229009945 CpcD/allophycocyanin linker domain; Region: CpcD; smart01094 251229009946 HEAT repeats; Region: HEAT_2; pfam13646 251229009947 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 251229009948 HEAT repeats; Region: HEAT_2; pfam13646 251229009949 HEAT repeats; Region: HEAT_2; pfam13646 251229009950 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 251229009951 phycocyanin beta subunit; Reviewed; Region: cpcB; CHL00171 251229009952 phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338 251229009953 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251229009954 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 251229009955 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 251229009956 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 251229009957 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 251229009958 PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130 251229009959 HEAT repeats; Region: HEAT_2; pfam13646 251229009960 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251229009961 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251229009962 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251229009963 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 251229009964 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 251229009965 NADP binding site [chemical binding]; other site 251229009966 active site 251229009967 putative substrate binding site [chemical binding]; other site 251229009968 ribosomal protein L21; Region: rpl21; CHL00075 251229009969 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 251229009970 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 251229009971 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 251229009972 PemK-like protein; Region: PemK; pfam02452 251229009973 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 251229009974 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 251229009975 XdhC Rossmann domain; Region: XdhC_C; pfam13478 251229009976 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 251229009977 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 251229009978 active site 251229009979 proline aminopeptidase P II; Provisional; Region: PRK10879 251229009980 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 251229009981 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 251229009982 active site 251229009983 AMIN domain; Region: AMIN; pfam11741 251229009984 Secretin and TonB N terminus short domain; Region: STN; pfam07660 251229009985 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 251229009986 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 251229009987 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 251229009988 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 251229009989 Cell division protein FtsA; Region: FtsA; cl17206 251229009990 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 251229009991 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 251229009992 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 251229009993 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 251229009994 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 251229009995 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 251229009996 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 251229009997 active site residue [active] 251229009998 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 251229009999 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229010000 putative active site [active] 251229010001 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 251229010002 HEAT repeats; Region: HEAT_2; pfam13646 251229010003 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 251229010004 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229010005 binding surface 251229010006 Tetratricopeptide repeat; Region: TPR_16; pfam13432 251229010007 TPR motif; other site 251229010008 PBP superfamily domain; Region: PBP_like_2; pfam12849 251229010009 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229010010 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229010011 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229010012 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229010013 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 251229010014 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229010015 motif II; other site 251229010016 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 251229010017 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 251229010018 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 251229010019 SnoaL-like domain; Region: SnoaL_2; pfam12680 251229010020 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251229010021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229010022 active site 251229010023 phosphorylation site [posttranslational modification] 251229010024 intermolecular recognition site; other site 251229010025 dimerization interface [polypeptide binding]; other site 251229010026 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251229010027 DNA binding residues [nucleotide binding] 251229010028 dimerization interface [polypeptide binding]; other site 251229010029 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229010030 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 251229010031 putative active site [active] 251229010032 heme pocket [chemical binding]; other site 251229010033 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229010034 putative active site [active] 251229010035 heme pocket [chemical binding]; other site 251229010036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229010037 dimer interface [polypeptide binding]; other site 251229010038 phosphorylation site [posttranslational modification] 251229010039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229010040 ATP binding site [chemical binding]; other site 251229010041 Mg2+ binding site [ion binding]; other site 251229010042 G-X-G motif; other site 251229010043 Response regulator receiver domain; Region: Response_reg; pfam00072 251229010044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229010045 active site 251229010046 phosphorylation site [posttranslational modification] 251229010047 intermolecular recognition site; other site 251229010048 dimerization interface [polypeptide binding]; other site 251229010049 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229010050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229010051 active site 251229010052 phosphorylation site [posttranslational modification] 251229010053 intermolecular recognition site; other site 251229010054 dimerization interface [polypeptide binding]; other site 251229010055 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229010056 PAS fold; Region: PAS_3; pfam08447 251229010057 putative active site [active] 251229010058 heme pocket [chemical binding]; other site 251229010059 PAS domain S-box; Region: sensory_box; TIGR00229 251229010060 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229010061 putative active site [active] 251229010062 heme pocket [chemical binding]; other site 251229010063 PAS domain; Region: PAS_9; pfam13426 251229010064 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229010065 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229010066 GAF domain; Region: GAF_3; pfam13492 251229010067 GAF domain; Region: GAF_2; pfam13185 251229010068 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229010069 dimer interface [polypeptide binding]; other site 251229010070 phosphorylation site [posttranslational modification] 251229010071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229010072 ATP binding site [chemical binding]; other site 251229010073 Mg2+ binding site [ion binding]; other site 251229010074 G-X-G motif; other site 251229010075 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 251229010076 CheB methylesterase; Region: CheB_methylest; pfam01339 251229010077 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 251229010078 CheB methylesterase; Region: CheB_methylest; pfam01339 251229010079 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 251229010080 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 251229010081 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 251229010082 PAS fold; Region: PAS; pfam00989 251229010083 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229010084 putative active site [active] 251229010085 heme pocket [chemical binding]; other site 251229010086 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 251229010087 PAS domain; Region: PAS_9; pfam13426 251229010088 putative active site [active] 251229010089 heme pocket [chemical binding]; other site 251229010090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229010091 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251229010092 putative active site [active] 251229010093 heme pocket [chemical binding]; other site 251229010094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229010095 dimer interface [polypeptide binding]; other site 251229010096 phosphorylation site [posttranslational modification] 251229010097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229010098 ATP binding site [chemical binding]; other site 251229010099 Mg2+ binding site [ion binding]; other site 251229010100 G-X-G motif; other site 251229010101 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 251229010102 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 251229010103 active site 251229010104 dimer interface [polypeptide binding]; other site 251229010105 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 251229010106 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 251229010107 active site 251229010108 FMN binding site [chemical binding]; other site 251229010109 substrate binding site [chemical binding]; other site 251229010110 3Fe-4S cluster binding site [ion binding]; other site 251229010111 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 251229010112 domain interface; other site 251229010113 argininosuccinate lyase; Provisional; Region: PRK00855 251229010114 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 251229010115 active sites [active] 251229010116 tetramer interface [polypeptide binding]; other site 251229010117 Predicted transcriptional regulator [Transcription]; Region: COG2345 251229010118 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251229010119 putative DNA binding site [nucleotide binding]; other site 251229010120 putative Zn2+ binding site [ion binding]; other site 251229010121 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 251229010122 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 251229010123 Response regulator receiver domain; Region: Response_reg; pfam00072 251229010124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229010125 active site 251229010126 phosphorylation site [posttranslational modification] 251229010127 intermolecular recognition site; other site 251229010128 dimerization interface [polypeptide binding]; other site 251229010129 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 251229010130 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 251229010131 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 251229010132 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251229010133 dimerization interface [polypeptide binding]; other site 251229010134 putative DNA binding site [nucleotide binding]; other site 251229010135 putative Zn2+ binding site [ion binding]; other site 251229010136 Clp amino terminal domain; Region: Clp_N; pfam02861 251229010137 Clp amino terminal domain; Region: Clp_N; pfam02861 251229010138 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229010139 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229010140 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229010141 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229010142 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229010143 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229010144 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 251229010145 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 251229010146 dimer interface [polypeptide binding]; other site 251229010147 putative CheW interface [polypeptide binding]; other site 251229010148 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 251229010149 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 251229010150 Walker A/P-loop; other site 251229010151 ATP binding site [chemical binding]; other site 251229010152 Q-loop/lid; other site 251229010153 ABC transporter signature motif; other site 251229010154 Walker B; other site 251229010155 D-loop; other site 251229010156 H-loop/switch region; other site 251229010157 DevC protein; Region: devC; TIGR01185 251229010158 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251229010159 FtsX-like permease family; Region: FtsX; pfam02687 251229010160 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 251229010161 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229010162 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 251229010163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229010164 S-adenosylmethionine binding site [chemical binding]; other site 251229010165 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 251229010166 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 251229010167 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 251229010168 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 251229010169 Zn2+ binding site [ion binding]; other site 251229010170 Mg2+ binding site [ion binding]; other site 251229010171 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 251229010172 synthetase active site [active] 251229010173 NTP binding site [chemical binding]; other site 251229010174 metal binding site [ion binding]; metal-binding site 251229010175 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 251229010176 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 251229010177 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 251229010178 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 251229010179 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 251229010180 putative acyl-acceptor binding pocket; other site 251229010181 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 251229010182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229010183 dimer interface [polypeptide binding]; other site 251229010184 conserved gate region; other site 251229010185 putative PBP binding loops; other site 251229010186 ABC-ATPase subunit interface; other site 251229010187 RNA methyltransferase, RsmE family; Region: TIGR00046 251229010188 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 251229010189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229010190 S-adenosylmethionine binding site [chemical binding]; other site 251229010191 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 251229010192 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229010193 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251229010194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229010195 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 251229010196 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 251229010197 putative NAD(P) binding site [chemical binding]; other site 251229010198 catalytic Zn binding site [ion binding]; other site 251229010199 structural Zn binding site [ion binding]; other site 251229010200 Protein of unknown function, DUF399; Region: DUF399; pfam04187 251229010201 VanZ like family; Region: VanZ; pfam04892 251229010202 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 251229010203 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 251229010204 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 251229010205 active site 251229010206 PUCC protein; Region: PUCC; pfam03209 251229010207 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251229010208 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 251229010209 active site 251229010210 catalytic tetrad [active] 251229010211 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 251229010212 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 251229010213 ATP binding site [chemical binding]; other site 251229010214 Mg++ binding site [ion binding]; other site 251229010215 motif III; other site 251229010216 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251229010217 nucleotide binding region [chemical binding]; other site 251229010218 ATP-binding site [chemical binding]; other site 251229010219 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 251229010220 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 251229010221 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251229010222 FeS/SAM binding site; other site 251229010223 TRAM domain; Region: TRAM; pfam01938 251229010224 Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434 251229010225 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 251229010226 putative active site [active] 251229010227 substrate binding site [chemical binding]; other site 251229010228 redox center [active] 251229010229 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 251229010230 CHASE2 domain; Region: CHASE2; pfam05226 251229010231 PAS domain S-box; Region: sensory_box; TIGR00229 251229010232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229010233 putative active site [active] 251229010234 heme pocket [chemical binding]; other site 251229010235 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229010236 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229010237 metal binding site [ion binding]; metal-binding site 251229010238 active site 251229010239 I-site; other site 251229010240 L-aspartate oxidase; Provisional; Region: PRK07395 251229010241 L-aspartate oxidase; Provisional; Region: PRK06175 251229010242 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 251229010243 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 251229010244 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 251229010245 Uncharacterized conserved protein [Function unknown]; Region: COG5607 251229010246 Esterase/lipase [General function prediction only]; Region: COG1647 251229010247 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 251229010248 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 251229010249 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 251229010250 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 251229010251 amidophosphoribosyltransferase; Region: purF; TIGR01134 251229010252 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229010253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229010254 dimer interface [polypeptide binding]; other site 251229010255 phosphorylation site [posttranslational modification] 251229010256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229010257 ATP binding site [chemical binding]; other site 251229010258 Mg2+ binding site [ion binding]; other site 251229010259 G-X-G motif; other site 251229010260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229010261 active site 251229010262 phosphorylation site [posttranslational modification] 251229010263 intermolecular recognition site; other site 251229010264 dimerization interface [polypeptide binding]; other site 251229010265 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 251229010266 tetramer interface [polypeptide binding]; other site 251229010267 dimer interface [polypeptide binding]; other site 251229010268 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 251229010269 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 251229010270 Walker A motif; other site 251229010271 ATP binding site [chemical binding]; other site 251229010272 Walker B motif; other site 251229010273 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 251229010274 ATP binding site [chemical binding]; other site 251229010275 Walker B motif; other site 251229010276 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 251229010277 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229010278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 251229010279 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 251229010280 O-Antigen ligase; Region: Wzy_C; pfam04932 251229010281 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 251229010282 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 251229010283 putative ligand binding site [chemical binding]; other site 251229010284 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 251229010285 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 251229010286 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 251229010287 TM-ABC transporter signature motif; other site 251229010288 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 251229010289 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 251229010290 TM-ABC transporter signature motif; other site 251229010291 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 251229010292 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 251229010293 Walker A/P-loop; other site 251229010294 ATP binding site [chemical binding]; other site 251229010295 Q-loop/lid; other site 251229010296 ABC transporter signature motif; other site 251229010297 Walker B; other site 251229010298 D-loop; other site 251229010299 H-loop/switch region; other site 251229010300 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 251229010301 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 251229010302 Walker A/P-loop; other site 251229010303 ATP binding site [chemical binding]; other site 251229010304 Q-loop/lid; other site 251229010305 ABC transporter signature motif; other site 251229010306 Walker B; other site 251229010307 D-loop; other site 251229010308 H-loop/switch region; other site 251229010309 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 251229010310 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 251229010311 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 251229010312 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229010313 active site 251229010314 Trm112p-like protein; Region: Trm112p; cl01066 251229010315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229010316 hypothetical protein; Provisional; Region: PRK08317 251229010317 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 251229010318 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 251229010319 Chain length determinant protein; Region: Wzz; pfam02706 251229010320 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 251229010321 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 251229010322 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229010323 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 251229010324 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229010325 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229010326 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 251229010327 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 251229010328 conserved cys residue [active] 251229010329 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229010330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229010331 S-adenosylmethionine binding site [chemical binding]; other site 251229010332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 251229010333 FIST N domain; Region: FIST; pfam08495 251229010334 FIST C domain; Region: FIST_C; pfam10442 251229010335 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 251229010336 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 251229010337 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 251229010338 Protein of unknown function (DUF565); Region: DUF565; pfam04483 251229010339 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 251229010340 active site 251229010341 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229010342 putative active site [active] 251229010343 Uncharacterized conserved protein [Function unknown]; Region: COG0397 251229010344 hypothetical protein; Validated; Region: PRK00029 251229010345 CP12 domain; Region: CP12; pfam02672 251229010346 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 251229010347 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 251229010348 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 251229010349 active site 251229010350 substrate binding site [chemical binding]; other site 251229010351 metal binding site [ion binding]; metal-binding site 251229010352 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251229010353 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 251229010354 active site 251229010355 catalytic tetrad [active] 251229010356 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 251229010357 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 251229010358 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 251229010359 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 251229010360 NADH(P)-binding; Region: NAD_binding_10; pfam13460 251229010361 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 251229010362 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 251229010363 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 251229010364 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251229010365 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229010366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229010367 Walker A/P-loop; other site 251229010368 ATP binding site [chemical binding]; other site 251229010369 Q-loop/lid; other site 251229010370 ABC transporter signature motif; other site 251229010371 Walker B; other site 251229010372 D-loop; other site 251229010373 H-loop/switch region; other site 251229010374 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251229010375 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 251229010376 active site 251229010377 metal binding site [ion binding]; metal-binding site 251229010378 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251229010379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 251229010380 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 251229010381 Uncharacterized conserved protein [Function unknown]; Region: COG2308 251229010382 Predicted metal-binding protein [Function unknown]; Region: COG5469 251229010383 light-harvesting-like protein 3; Provisional; Region: PLN00014 251229010384 tyramine oxidase; Provisional; Region: tynA; PRK11504 251229010385 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 251229010386 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 251229010387 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 251229010388 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 251229010389 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 251229010390 putative trimer interface [polypeptide binding]; other site 251229010391 putative CoA binding site [chemical binding]; other site 251229010392 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 251229010393 putative trimer interface [polypeptide binding]; other site 251229010394 putative CoA binding site [chemical binding]; other site 251229010395 phosphoglucomutase; Region: PLN02307 251229010396 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 251229010397 substrate binding site [chemical binding]; other site 251229010398 dimer interface [polypeptide binding]; other site 251229010399 active site 251229010400 metal binding site [ion binding]; metal-binding site 251229010401 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 251229010402 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 251229010403 HEAT repeats; Region: HEAT_2; pfam13646 251229010404 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 251229010405 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 251229010406 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 251229010407 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 251229010408 NMT1-like family; Region: NMT1_2; pfam13379 251229010409 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 251229010410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229010411 dimer interface [polypeptide binding]; other site 251229010412 conserved gate region; other site 251229010413 putative PBP binding loops; other site 251229010414 ABC-ATPase subunit interface; other site 251229010415 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 251229010416 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 251229010417 Walker A/P-loop; other site 251229010418 ATP binding site [chemical binding]; other site 251229010419 Q-loop/lid; other site 251229010420 ABC transporter signature motif; other site 251229010421 Walker B; other site 251229010422 D-loop; other site 251229010423 H-loop/switch region; other site 251229010424 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 251229010425 NMT1-like family; Region: NMT1_2; pfam13379 251229010426 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 251229010427 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 251229010428 Walker A/P-loop; other site 251229010429 ATP binding site [chemical binding]; other site 251229010430 Q-loop/lid; other site 251229010431 ABC transporter signature motif; other site 251229010432 Walker B; other site 251229010433 D-loop; other site 251229010434 H-loop/switch region; other site 251229010435 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 251229010436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229010437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229010438 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 251229010439 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 251229010440 [4Fe-4S] binding site [ion binding]; other site 251229010441 molybdopterin cofactor binding site; other site 251229010442 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 251229010443 molybdopterin cofactor binding site; other site 251229010444 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 251229010445 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 251229010446 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229010447 binding surface 251229010448 TPR motif; other site 251229010449 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 251229010450 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 251229010451 Na binding site [ion binding]; other site 251229010452 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 251229010453 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 251229010454 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 251229010455 putative dimer interface [polypeptide binding]; other site 251229010456 N-terminal domain interface [polypeptide binding]; other site 251229010457 putative substrate binding pocket (H-site) [chemical binding]; other site 251229010458 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 251229010459 hypothetical protein; Reviewed; Region: PRK09588 251229010460 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 251229010461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 251229010462 putative phosphatase; Provisional; Region: PRK11587 251229010463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229010464 active site 251229010465 motif I; other site 251229010466 motif II; other site 251229010467 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 251229010468 non-specific DNA interactions [nucleotide binding]; other site 251229010469 DNA binding site [nucleotide binding] 251229010470 sequence specific DNA binding site [nucleotide binding]; other site 251229010471 putative cAMP binding site [chemical binding]; other site 251229010472 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 251229010473 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 251229010474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229010475 S-adenosylmethionine binding site [chemical binding]; other site 251229010476 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 251229010477 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229010478 motif II; other site 251229010479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 251229010480 non-specific DNA binding site [nucleotide binding]; other site 251229010481 salt bridge; other site 251229010482 sequence-specific DNA binding site [nucleotide binding]; other site 251229010483 Predicted helicase [General function prediction only]; Region: COG4889 251229010484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 251229010485 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 251229010486 oligomeric interface; other site 251229010487 putative active site [active] 251229010488 homodimer interface [polypeptide binding]; other site 251229010489 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 251229010490 PLD-like domain; Region: PLDc_2; pfam13091 251229010491 putative active site [active] 251229010492 catalytic site [active] 251229010493 DEAD-like helicases superfamily; Region: DEXDc; smart00487 251229010494 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 251229010495 ATP binding site [chemical binding]; other site 251229010496 putative Mg++ binding site [ion binding]; other site 251229010497 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251229010498 nucleotide binding region [chemical binding]; other site 251229010499 ATP-binding site [chemical binding]; other site 251229010500 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 251229010501 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 251229010502 Sodium Bile acid symporter family; Region: SBF; pfam01758 251229010503 Cupin domain; Region: Cupin_2; pfam07883 251229010504 Domain of unknown function (DUF305); Region: DUF305; cl17794 251229010505 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229010506 HAMP domain; Region: HAMP; pfam00672 251229010507 dimerization interface [polypeptide binding]; other site 251229010508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229010509 dimer interface [polypeptide binding]; other site 251229010510 phosphorylation site [posttranslational modification] 251229010511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229010512 ATP binding site [chemical binding]; other site 251229010513 Mg2+ binding site [ion binding]; other site 251229010514 G-X-G motif; other site 251229010515 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 251229010516 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 251229010517 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229010518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229010519 active site 251229010520 phosphorylation site [posttranslational modification] 251229010521 intermolecular recognition site; other site 251229010522 dimerization interface [polypeptide binding]; other site 251229010523 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229010524 DNA binding site [nucleotide binding] 251229010525 alpha-glucosidase; Provisional; Region: PRK10137 251229010526 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 251229010527 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 251229010528 active site 251229010529 metal binding site [ion binding]; metal-binding site 251229010530 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229010531 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229010532 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 251229010533 active site 251229010534 metal binding site [ion binding]; metal-binding site 251229010535 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 251229010536 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 251229010537 FAD binding pocket [chemical binding]; other site 251229010538 FAD binding motif [chemical binding]; other site 251229010539 phosphate binding motif [ion binding]; other site 251229010540 beta-alpha-beta structure motif; other site 251229010541 NAD binding pocket [chemical binding]; other site 251229010542 Heme binding pocket [chemical binding]; other site 251229010543 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251229010544 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 251229010545 catalytic loop [active] 251229010546 iron binding site [ion binding]; other site 251229010547 MIP family channel proteins; Region: MIP; TIGR00861 251229010548 amphipathic channel; other site 251229010549 Asn-Pro-Ala signature motifs; other site 251229010550 Predicted flavoprotein [General function prediction only]; Region: COG0431 251229010551 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 251229010552 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 251229010553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229010554 NAD(P) binding site [chemical binding]; other site 251229010555 active site 251229010556 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 251229010557 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251229010558 ligand binding site [chemical binding]; other site 251229010559 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 251229010560 putative switch regulator; other site 251229010561 non-specific DNA interactions [nucleotide binding]; other site 251229010562 DNA binding site [nucleotide binding] 251229010563 sequence specific DNA binding site [nucleotide binding]; other site 251229010564 putative cAMP binding site [chemical binding]; other site 251229010565 SnoaL-like domain; Region: SnoaL_3; pfam13474 251229010566 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 251229010567 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251229010568 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229010569 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 251229010570 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 251229010571 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 251229010572 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 251229010573 siderophore binding site; other site 251229010574 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251229010575 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229010576 AMIN domain; Region: AMIN; pfam11741 251229010577 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251229010578 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229010579 N-terminal plug; other site 251229010580 ligand-binding site [chemical binding]; other site 251229010581 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 251229010582 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 251229010583 siderophore binding site; other site 251229010584 Protein of unknown function (DUF1636); Region: DUF1636; cl17843 251229010585 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251229010586 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229010587 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 251229010588 Walker A/P-loop; other site 251229010589 ATP binding site [chemical binding]; other site 251229010590 Q-loop/lid; other site 251229010591 ABC transporter signature motif; other site 251229010592 Walker B; other site 251229010593 D-loop; other site 251229010594 H-loop/switch region; other site 251229010595 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251229010596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229010597 AMIN domain; Region: AMIN; pfam11741 251229010598 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251229010599 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229010600 N-terminal plug; other site 251229010601 ligand-binding site [chemical binding]; other site 251229010602 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 251229010603 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 251229010604 siderophore binding site; other site 251229010605 XisI protein; Region: XisI; pfam08869 251229010606 XisH protein; Region: XisH; pfam08814 251229010607 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 251229010608 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 251229010609 ABC-ATPase subunit interface; other site 251229010610 dimer interface [polypeptide binding]; other site 251229010611 putative PBP binding regions; other site 251229010612 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 251229010613 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 251229010614 ABC-ATPase subunit interface; other site 251229010615 dimer interface [polypeptide binding]; other site 251229010616 putative PBP binding regions; other site 251229010617 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 251229010618 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 251229010619 Walker A/P-loop; other site 251229010620 ATP binding site [chemical binding]; other site 251229010621 Q-loop/lid; other site 251229010622 ABC transporter signature motif; other site 251229010623 Walker B; other site 251229010624 D-loop; other site 251229010625 H-loop/switch region; other site 251229010626 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 251229010627 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229010628 H+ Antiporter protein; Region: 2A0121; TIGR00900 251229010629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229010630 putative substrate translocation pore; other site 251229010631 AMIN domain; Region: AMIN; pfam11741 251229010632 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251229010633 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229010634 N-terminal plug; other site 251229010635 ligand-binding site [chemical binding]; other site 251229010636 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 251229010637 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 251229010638 siderophore binding site; other site 251229010639 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 251229010640 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251229010641 active site 251229010642 metal binding site [ion binding]; metal-binding site 251229010643 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251229010644 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229010645 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229010646 Walker A/P-loop; other site 251229010647 ATP binding site [chemical binding]; other site 251229010648 Q-loop/lid; other site 251229010649 ABC transporter signature motif; other site 251229010650 Walker B; other site 251229010651 D-loop; other site 251229010652 H-loop/switch region; other site 251229010653 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251229010654 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229010655 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 251229010656 Walker A/P-loop; other site 251229010657 ATP binding site [chemical binding]; other site 251229010658 Q-loop/lid; other site 251229010659 ABC transporter signature motif; other site 251229010660 Walker B; other site 251229010661 D-loop; other site 251229010662 H-loop/switch region; other site 251229010663 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 251229010664 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 251229010665 AMIN domain; Region: AMIN; pfam11741 251229010666 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 251229010667 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229010668 N-terminal plug; other site 251229010669 ligand-binding site [chemical binding]; other site 251229010670 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 251229010671 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 251229010672 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 251229010673 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 251229010674 acyl-activating enzyme (AAE) consensus motif; other site 251229010675 AMP binding site [chemical binding]; other site 251229010676 active site 251229010677 CoA binding site [chemical binding]; other site 251229010678 salicylate synthase; Region: salicyl_syn; TIGR03494 251229010679 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 251229010680 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 251229010681 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 251229010682 serine O-acetyltransferase; Region: cysE; TIGR01172 251229010683 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 251229010684 trimer interface [polypeptide binding]; other site 251229010685 active site 251229010686 substrate binding site [chemical binding]; other site 251229010687 CoA binding site [chemical binding]; other site 251229010688 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 251229010689 dimer interface [polypeptide binding]; other site 251229010690 active site 251229010691 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 251229010692 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229010693 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 251229010694 Condensation domain; Region: Condensation; pfam00668 251229010695 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229010696 Nonribosomal peptide synthase; Region: NRPS; pfam08415 251229010697 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 251229010698 acyl-activating enzyme (AAE) consensus motif; other site 251229010699 AMP binding site [chemical binding]; other site 251229010700 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229010701 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 251229010702 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 251229010703 active site 251229010704 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 251229010705 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 251229010706 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 251229010707 putative NADP binding site [chemical binding]; other site 251229010708 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 251229010709 active site 251229010710 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 251229010711 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 251229010712 Enoylreductase; Region: PKS_ER; smart00829 251229010713 NAD(P) binding site [chemical binding]; other site 251229010714 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229010715 Condensation domain; Region: Condensation; pfam00668 251229010716 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229010717 Nonribosomal peptide synthase; Region: NRPS; pfam08415 251229010718 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 251229010719 acyl-activating enzyme (AAE) consensus motif; other site 251229010720 AMP binding site [chemical binding]; other site 251229010721 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 251229010722 putative FMN binding site [chemical binding]; other site 251229010723 NADPH bind site [chemical binding]; other site 251229010724 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 251229010725 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229010726 Condensation domain; Region: Condensation; pfam00668 251229010727 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229010728 Nonribosomal peptide synthase; Region: NRPS; pfam08415 251229010729 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 251229010730 acyl-activating enzyme (AAE) consensus motif; other site 251229010731 AMP binding site [chemical binding]; other site 251229010732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229010733 S-adenosylmethionine binding site [chemical binding]; other site 251229010734 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 251229010735 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229010736 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 251229010737 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229010738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229010739 S-adenosylmethionine binding site [chemical binding]; other site 251229010740 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 251229010741 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 251229010742 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 251229010743 active site 251229010744 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 251229010745 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 251229010746 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 251229010747 putative NADP binding site [chemical binding]; other site 251229010748 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 251229010749 active site 251229010750 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229010751 Condensation domain; Region: Condensation; pfam00668 251229010752 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229010753 Nonribosomal peptide synthase; Region: NRPS; pfam08415 251229010754 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 251229010755 acyl-activating enzyme (AAE) consensus motif; other site 251229010756 AMP binding site [chemical binding]; other site 251229010757 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229010758 Condensation domain; Region: Condensation; pfam00668 251229010759 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229010760 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 251229010761 acyltransferase PapA5; Provisional; Region: PRK09294 251229010762 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 251229010763 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 251229010764 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 251229010765 putative NADP binding site [chemical binding]; other site 251229010766 active site 251229010767 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229010768 AMIN domain; Region: AMIN; pfam11741 251229010769 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 251229010770 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229010771 N-terminal plug; other site 251229010772 ligand-binding site [chemical binding]; other site 251229010773 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 251229010774 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 251229010775 siderophore binding site; other site 251229010776 H+ Antiporter protein; Region: 2A0121; TIGR00900 251229010777 H+ Antiporter protein; Region: 2A0121; TIGR00900 251229010778 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229010779 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229010780 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229010781 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229010782 prefoldin subunit beta; Provisional; Region: PRK09343 251229010783 Uncharacterized conserved protein [Function unknown]; Region: COG1262 251229010784 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 251229010785 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 251229010786 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 251229010787 Soluble P-type ATPase [General function prediction only]; Region: COG4087 251229010788 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 251229010789 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 251229010790 Soluble P-type ATPase [General function prediction only]; Region: COG4087 251229010791 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 251229010792 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 251229010793 Soluble P-type ATPase [General function prediction only]; Region: COG4087 251229010794 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 251229010795 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 251229010796 calcium/proton exchanger (cax); Region: cax; TIGR00378 251229010797 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 251229010798 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 251229010799 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 251229010800 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 251229010801 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 251229010802 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 251229010803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229010804 motif II; other site 251229010805 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 251229010806 Protein of unknown function (DUF454); Region: DUF454; cl01063 251229010807 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 251229010808 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 251229010809 Switch I; other site 251229010810 cytokinin dehydrogenase; Region: PLN02441 251229010811 FAD binding domain; Region: FAD_binding_4; pfam01565 251229010812 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 251229010813 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 251229010814 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 251229010815 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 251229010816 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 251229010817 metal-binding site [ion binding] 251229010818 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 251229010819 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 251229010820 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 251229010821 metal-binding site [ion binding] 251229010822 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 251229010823 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 251229010824 ABC-ATPase subunit interface; other site 251229010825 dimer interface [polypeptide binding]; other site 251229010826 putative PBP binding regions; other site 251229010827 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 251229010828 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 251229010829 ABC-ATPase subunit interface; other site 251229010830 dimer interface [polypeptide binding]; other site 251229010831 putative PBP binding regions; other site 251229010832 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 251229010833 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 251229010834 siderophore binding site; other site 251229010835 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 251229010836 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251229010837 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229010838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229010839 Walker A/P-loop; other site 251229010840 ATP binding site [chemical binding]; other site 251229010841 Q-loop/lid; other site 251229010842 ABC transporter signature motif; other site 251229010843 Walker B; other site 251229010844 D-loop; other site 251229010845 H-loop/switch region; other site 251229010846 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229010847 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 251229010848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229010849 Walker A/P-loop; other site 251229010850 ATP binding site [chemical binding]; other site 251229010851 Q-loop/lid; other site 251229010852 ABC transporter signature motif; other site 251229010853 Walker B; other site 251229010854 D-loop; other site 251229010855 H-loop/switch region; other site 251229010856 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 251229010857 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 251229010858 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 251229010859 siderophore binding site; other site 251229010860 AMIN domain; Region: AMIN; pfam11741 251229010861 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251229010862 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229010863 N-terminal plug; other site 251229010864 ligand-binding site [chemical binding]; other site 251229010865 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 251229010866 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 251229010867 acyl-activating enzyme (AAE) consensus motif; other site 251229010868 active site 251229010869 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 251229010870 Condensation domain; Region: Condensation; pfam00668 251229010871 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229010872 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 251229010873 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 251229010874 acyl-activating enzyme (AAE) consensus motif; other site 251229010875 AMP binding site [chemical binding]; other site 251229010876 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229010877 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 251229010878 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 251229010879 active site 251229010880 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 251229010881 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 251229010882 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 251229010883 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 251229010884 putative NADP binding site [chemical binding]; other site 251229010885 active site 251229010886 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229010887 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 251229010888 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 251229010889 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 251229010890 Condensation domain; Region: Condensation; pfam00668 251229010891 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229010892 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 251229010893 Condensation domain; Region: Condensation; pfam00668 251229010894 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 251229010895 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 251229010896 acyl-activating enzyme (AAE) consensus motif; other site 251229010897 AMP binding site [chemical binding]; other site 251229010898 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229010899 Condensation domain; Region: Condensation; pfam00668 251229010900 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229010901 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 251229010902 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 251229010903 Condensation domain; Region: Condensation; pfam00668 251229010904 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 251229010905 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 251229010906 acyl-activating enzyme (AAE) consensus motif; other site 251229010907 AMP binding site [chemical binding]; other site 251229010908 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229010909 Condensation domain; Region: Condensation; pfam00668 251229010910 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229010911 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 251229010912 Condensation domain; Region: Condensation; pfam00668 251229010913 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229010914 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 251229010915 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 251229010916 acyl-activating enzyme (AAE) consensus motif; other site 251229010917 AMP binding site [chemical binding]; other site 251229010918 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229010919 Condensation domain; Region: Condensation; pfam00668 251229010920 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229010921 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 251229010922 Condensation domain; Region: Condensation; pfam00668 251229010923 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229010924 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 251229010925 acyl-activating enzyme (AAE) consensus motif; other site 251229010926 AMP binding site [chemical binding]; other site 251229010927 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229010928 Condensation domain; Region: Condensation; pfam00668 251229010929 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229010930 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 251229010931 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 251229010932 acyl-activating enzyme (AAE) consensus motif; other site 251229010933 AMP binding site [chemical binding]; other site 251229010934 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229010935 Condensation domain; Region: Condensation; pfam00668 251229010936 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229010937 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 251229010938 Condensation domain; Region: Condensation; pfam00668 251229010939 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229010940 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229010941 Condensation domain; Region: Condensation; pfam00668 251229010942 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229010943 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 251229010944 Condensation domain; Region: Condensation; pfam00668 251229010945 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 251229010946 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 251229010947 acyl-activating enzyme (AAE) consensus motif; other site 251229010948 AMP binding site [chemical binding]; other site 251229010949 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229010950 Condensation domain; Region: Condensation; pfam00668 251229010951 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 251229010952 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 251229010953 Condensation domain; Region: Condensation; pfam00668 251229010954 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 251229010955 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 251229010956 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 251229010957 acyl-activating enzyme (AAE) consensus motif; other site 251229010958 AMP binding site [chemical binding]; other site 251229010959 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 251229010960 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 251229010961 putative NAD(P) binding site [chemical binding]; other site 251229010962 active site 251229010963 putative substrate binding site [chemical binding]; other site 251229010964 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 251229010965 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 251229010966 inhibitor-cofactor binding pocket; inhibition site 251229010967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229010968 catalytic residue [active] 251229010969 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 251229010970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229010971 S-adenosylmethionine binding site [chemical binding]; other site 251229010972 MbtH-like protein; Region: MbtH; cl01279 251229010973 Penicillin amidase; Region: Penicil_amidase; pfam01804 251229010974 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 251229010975 active site 251229010976 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 251229010977 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 251229010978 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 251229010979 active site 251229010980 catalytic residues [active] 251229010981 DNA binding site [nucleotide binding] 251229010982 Int/Topo IB signature motif; other site 251229010983 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 251229010984 CHAT domain; Region: CHAT; cl17868 251229010985 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 251229010986 CHASE2 domain; Region: CHASE2; pfam05226 251229010987 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 251229010988 TPR repeat; Region: TPR_11; pfam13414 251229010989 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251229010990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 251229010991 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 251229010992 haemagglutination activity domain; Region: Haemagg_act; pfam05860 251229010993 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 251229010994 haemagglutination activity domain; Region: Haemagg_act; pfam05860 251229010995 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 251229010996 HlyD family secretion protein; Region: HlyD; pfam00529 251229010997 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 251229010998 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229010999 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 251229011000 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 251229011001 putative active site [active] 251229011002 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229011003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229011004 Walker A/P-loop; other site 251229011005 ATP binding site [chemical binding]; other site 251229011006 Q-loop/lid; other site 251229011007 ABC transporter signature motif; other site 251229011008 Walker B; other site 251229011009 D-loop; other site 251229011010 H-loop/switch region; other site 251229011011 Beta/Gamma crystallin; Region: Crystall; cl02528 251229011012 Homeodomain-like domain; Region: HTH_23; pfam13384 251229011013 Winged helix-turn helix; Region: HTH_29; pfam13551 251229011014 Winged helix-turn helix; Region: HTH_33; pfam13592 251229011015 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 251229011016 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 251229011017 Helix-turn-helix domain; Region: HTH_28; pfam13518 251229011018 Winged helix-turn helix; Region: HTH_33; pfam13592 251229011019 DDE superfamily endonuclease; Region: DDE_3; pfam13358 251229011020 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 251229011021 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 251229011022 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 251229011023 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 251229011024 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251229011025 ATP binding site [chemical binding]; other site 251229011026 putative Mg++ binding site [ion binding]; other site 251229011027 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 251229011028 nucleotide binding region [chemical binding]; other site 251229011029 ATP-binding site [chemical binding]; other site 251229011030 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 251229011031 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 251229011032 HsdM N-terminal domain; Region: HsdM_N; pfam12161 251229011033 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 251229011034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229011035 S-adenosylmethionine binding site [chemical binding]; other site 251229011036 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 251229011037 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 251229011038 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 251229011039 active site 251229011040 NTP binding site [chemical binding]; other site 251229011041 metal binding triad [ion binding]; metal-binding site 251229011042 antibiotic binding site [chemical binding]; other site 251229011043 Uncharacterized conserved protein [Function unknown]; Region: COG2361 251229011044 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 251229011045 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 251229011046 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 251229011047 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 251229011048 oligomeric interface; other site 251229011049 putative active site [active] 251229011050 homodimer interface [polypeptide binding]; other site 251229011051 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 251229011052 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 251229011053 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 251229011054 active site 251229011055 dimer interface [polypeptide binding]; other site 251229011056 motif 1; other site 251229011057 motif 2; other site 251229011058 motif 3; other site 251229011059 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 251229011060 anticodon binding site; other site 251229011061 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 251229011062 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 251229011063 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 251229011064 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 251229011065 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 251229011066 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 251229011067 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 251229011068 homodecamer interface [polypeptide binding]; other site 251229011069 GTP cyclohydrolase I; Provisional; Region: PLN03044 251229011070 active site 251229011071 putative catalytic site residues [active] 251229011072 zinc binding site [ion binding]; other site 251229011073 GTP-CH-I/GFRP interaction surface; other site 251229011074 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 251229011075 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 251229011076 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 251229011077 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 251229011078 PIN domain; Region: PIN_3; pfam13470 251229011079 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 251229011080 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 251229011081 active site 251229011082 Int/Topo IB signature motif; other site 251229011083 DNA binding site [nucleotide binding] 251229011084 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 251229011085 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 251229011086 active site 251229011087 catalytic residues [active] 251229011088 DNA binding site [nucleotide binding] 251229011089 Int/Topo IB signature motif; other site 251229011090 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 251229011091 Protein of unknown function (DUF499); Region: DUF499; pfam04465 251229011092 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 251229011093 four helix bundle protein; Region: TIGR02436 251229011094 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 251229011095 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 251229011096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 251229011097 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229011098 putative active site [active] 251229011099 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 251229011100 putative active site [active] 251229011101 DEAD-like helicases superfamily; Region: DEXDc; smart00487 251229011102 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251229011103 ATP binding site [chemical binding]; other site 251229011104 putative Mg++ binding site [ion binding]; other site 251229011105 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251229011106 nucleotide binding region [chemical binding]; other site 251229011107 ATP-binding site [chemical binding]; other site 251229011108 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 251229011109 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 251229011110 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 251229011111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 251229011112 Family of unknown function (DUF490); Region: DUF490; pfam04357 251229011113 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 251229011114 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 251229011115 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 251229011116 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 251229011117 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 251229011118 Beta-lactamase; Region: Beta-lactamase; pfam00144 251229011119 Protein of unknown function (DUF460); Region: DUF460; pfam04312 251229011120 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 251229011121 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 251229011122 PRC-barrel domain; Region: PRC; pfam05239 251229011123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 251229011124 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 251229011125 Fasciclin domain; Region: Fasciclin; pfam02469 251229011126 S-layer homology domain; Region: SLH; pfam00395 251229011127 S-layer homology domain; Region: SLH; pfam00395 251229011128 S-layer homology domain; Region: SLH; pfam00395 251229011129 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229011130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229011131 active site 251229011132 phosphorylation site [posttranslational modification] 251229011133 intermolecular recognition site; other site 251229011134 dimerization interface [polypeptide binding]; other site 251229011135 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229011136 DNA binding site [nucleotide binding] 251229011137 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 251229011138 putative binding surface; other site 251229011139 active site 251229011140 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 251229011141 PAS domain S-box; Region: sensory_box; TIGR00229 251229011142 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229011143 putative active site [active] 251229011144 heme pocket [chemical binding]; other site 251229011145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229011146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229011147 dimer interface [polypeptide binding]; other site 251229011148 phosphorylation site [posttranslational modification] 251229011149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229011150 ATP binding site [chemical binding]; other site 251229011151 Mg2+ binding site [ion binding]; other site 251229011152 G-X-G motif; other site 251229011153 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229011154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229011155 active site 251229011156 phosphorylation site [posttranslational modification] 251229011157 intermolecular recognition site; other site 251229011158 dimerization interface [polypeptide binding]; other site 251229011159 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 251229011160 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229011161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229011162 active site 251229011163 phosphorylation site [posttranslational modification] 251229011164 intermolecular recognition site; other site 251229011165 dimerization interface [polypeptide binding]; other site 251229011166 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 251229011167 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 251229011168 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 251229011169 protein binding site [polypeptide binding]; other site 251229011170 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 251229011171 PRC-barrel domain; Region: PRC; pfam05239 251229011172 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 251229011173 Heat induced stress protein YflT; Region: YflT; pfam11181 251229011174 Peptidase family M48; Region: Peptidase_M48; pfam01435 251229011175 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 251229011176 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 251229011177 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 251229011178 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 251229011179 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 251229011180 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 251229011181 putative active site [active] 251229011182 putative metal binding site [ion binding]; other site 251229011183 Bacterial SH3 domain; Region: SH3_3; cl17532 251229011184 Bacterial SH3 domain; Region: SH3_3; cl17532 251229011185 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 251229011186 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 251229011187 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 251229011188 trimer interface [polypeptide binding]; other site 251229011189 active site 251229011190 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 251229011191 catalytic site [active] 251229011192 Ion transport protein; Region: Ion_trans; pfam00520 251229011193 Ion channel; Region: Ion_trans_2; pfam07885 251229011194 Predicted membrane protein [Function unknown]; Region: COG1808 251229011195 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 251229011196 Mechanosensitive ion channel; Region: MS_channel; pfam00924 251229011197 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 251229011198 Mechanosensitive ion channel; Region: MS_channel; pfam00924 251229011199 Predicted membrane protein [Function unknown]; Region: COG4325 251229011200 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 251229011201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229011202 S-adenosylmethionine binding site [chemical binding]; other site 251229011203 AAA ATPase domain; Region: AAA_16; pfam13191 251229011204 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 251229011205 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 251229011206 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 251229011207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 251229011208 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 251229011209 Cytochrome P450; Region: p450; pfam00067 251229011210 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 251229011211 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 251229011212 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 251229011213 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 251229011214 putative active site [active] 251229011215 catalytic site [active] 251229011216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229011217 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 251229011218 Walker A motif; other site 251229011219 ATP binding site [chemical binding]; other site 251229011220 Walker B motif; other site 251229011221 arginine finger; other site 251229011222 Predicted metal-binding protein [General function prediction only]; Region: COG3019 251229011223 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251229011224 active site 251229011225 catalytic tetrad [active] 251229011226 cytokinin dehydrogenase; Region: PLN02441 251229011227 FAD binding domain; Region: FAD_binding_4; pfam01565 251229011228 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 251229011229 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229011230 Walker A/P-loop; other site 251229011231 ATP binding site [chemical binding]; other site 251229011232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229011233 ABC transporter signature motif; other site 251229011234 Walker B; other site 251229011235 D-loop; other site 251229011236 H-loop/switch region; other site 251229011237 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 251229011238 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 251229011239 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 251229011240 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 251229011241 XisI protein; Region: XisI; pfam08869 251229011242 Methyltransferase domain; Region: Methyltransf_26; pfam13659 251229011243 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 251229011244 Methyltransferase domain; Region: Methyltransf_26; pfam13659 251229011245 DNA polymerase III subunit delta; Validated; Region: PRK07452 251229011246 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 251229011247 DNA polymerase III subunit delta'; Validated; Region: PRK07399 251229011248 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 251229011249 oligomeric interface; other site 251229011250 putative active site [active] 251229011251 homodimer interface [polypeptide binding]; other site 251229011252 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 251229011253 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 251229011254 dimer interface [polypeptide binding]; other site 251229011255 ssDNA binding site [nucleotide binding]; other site 251229011256 tetramer (dimer of dimers) interface [polypeptide binding]; other site 251229011257 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 251229011258 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 251229011259 short chain dehydrogenase; Provisional; Region: PRK06500 251229011260 classical (c) SDRs; Region: SDR_c; cd05233 251229011261 NAD(P) binding site [chemical binding]; other site 251229011262 active site 251229011263 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 251229011264 homotrimer interaction site [polypeptide binding]; other site 251229011265 putative active site [active] 251229011266 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229011267 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 251229011268 active site 251229011269 choline dehydrogenase; Validated; Region: PRK02106 251229011270 hydroxyglutarate oxidase; Provisional; Region: PRK11728 251229011271 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 251229011272 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251229011273 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 251229011274 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 251229011275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229011276 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251229011277 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 251229011278 catalytic site [active] 251229011279 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 251229011280 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 251229011281 putative NAD(P) binding site [chemical binding]; other site 251229011282 Predicted transcriptional regulators [Transcription]; Region: COG1733 251229011283 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 251229011284 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 251229011285 Winged helix-turn helix; Region: HTH_29; pfam13551 251229011286 Helix-turn-helix domain; Region: HTH_28; pfam13518 251229011287 Winged helix-turn helix; Region: HTH_33; pfam13592 251229011288 DDE superfamily endonuclease; Region: DDE_3; pfam13358 251229011289 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 251229011290 transcriptional regulator NarL; Provisional; Region: PRK10651 251229011291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229011292 active site 251229011293 phosphorylation site [posttranslational modification] 251229011294 intermolecular recognition site; other site 251229011295 dimerization interface [polypeptide binding]; other site 251229011296 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251229011297 DNA binding residues [nucleotide binding] 251229011298 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229011299 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229011300 active site 251229011301 ATP binding site [chemical binding]; other site 251229011302 substrate binding site [chemical binding]; other site 251229011303 activation loop (A-loop); other site 251229011304 AAA ATPase domain; Region: AAA_16; pfam13191 251229011305 Predicted ATPase [General function prediction only]; Region: COG3899 251229011306 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229011307 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229011308 PAS fold; Region: PAS_4; pfam08448 251229011309 PAS domain S-box; Region: sensory_box; TIGR00229 251229011310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229011311 putative active site [active] 251229011312 heme pocket [chemical binding]; other site 251229011313 PAS fold; Region: PAS_4; pfam08448 251229011314 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 251229011315 Histidine kinase; Region: HisKA_3; pfam07730 251229011316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229011317 ATP binding site [chemical binding]; other site 251229011318 Mg2+ binding site [ion binding]; other site 251229011319 G-X-G motif; other site 251229011320 Beta/gamma crystallins; Region: XTALbg; smart00247 251229011321 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 251229011322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229011323 NAD(P) binding site [chemical binding]; other site 251229011324 active site 251229011325 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 251229011326 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 251229011327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229011328 phosphoenolpyruvate synthase; Validated; Region: PRK06241 251229011329 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 251229011330 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 251229011331 metal ion-dependent adhesion site (MIDAS); other site 251229011332 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 251229011333 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 251229011334 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 251229011335 metal ion-dependent adhesion site (MIDAS); other site 251229011336 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 251229011337 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251229011338 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 251229011339 phosphopeptide binding site; other site 251229011340 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 251229011341 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 251229011342 Protein phosphatase 2C; Region: PP2C; pfam00481 251229011343 active site 251229011344 Ribosomal protein S27; Region: Ribosomal_S27e; cl00897 251229011345 Protein kinase domain; Region: Pkinase; pfam00069 251229011346 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229011347 active site 251229011348 ATP binding site [chemical binding]; other site 251229011349 substrate binding site [chemical binding]; other site 251229011350 activation loop (A-loop); other site 251229011351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229011352 TPR motif; other site 251229011353 binding surface 251229011354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229011355 binding surface 251229011356 TPR motif; other site 251229011357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229011358 binding surface 251229011359 TPR motif; other site 251229011360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229011361 binding surface 251229011362 TPR repeat; Region: TPR_11; pfam13414 251229011363 TPR motif; other site 251229011364 TPR repeat; Region: TPR_11; pfam13414 251229011365 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 251229011366 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 251229011367 four helix bundle protein; Region: TIGR02436 251229011368 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 251229011369 Mg binding site [ion binding]; other site 251229011370 nucleotide binding site [chemical binding]; other site 251229011371 putative protofilament interface [polypeptide binding]; other site 251229011372 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 251229011373 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 251229011374 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 251229011375 Cupin domain; Region: Cupin_2; pfam07883 251229011376 ornithine carbamoyltransferase; Provisional; Region: PRK00779 251229011377 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 251229011378 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 251229011379 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 251229011380 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 251229011381 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 251229011382 Catalytic site [active] 251229011383 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229011384 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 251229011385 active site 251229011386 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 251229011387 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251229011388 ATP binding site [chemical binding]; other site 251229011389 putative Mg++ binding site [ion binding]; other site 251229011390 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251229011391 nucleotide binding region [chemical binding]; other site 251229011392 ATP-binding site [chemical binding]; other site 251229011393 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 251229011394 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229011395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229011396 active site 251229011397 phosphorylation site [posttranslational modification] 251229011398 intermolecular recognition site; other site 251229011399 dimerization interface [polypeptide binding]; other site 251229011400 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229011401 DNA binding site [nucleotide binding] 251229011402 geranylgeranyl reductase; Region: ChlP; TIGR02028 251229011403 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 251229011404 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 251229011405 Sporulation and spore germination; Region: Germane; pfam10646 251229011406 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251229011407 dimerization interface [polypeptide binding]; other site 251229011408 putative DNA binding site [nucleotide binding]; other site 251229011409 putative Zn2+ binding site [ion binding]; other site 251229011410 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 251229011411 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 251229011412 carboxyltransferase (CT) interaction site; other site 251229011413 biotinylation site [posttranslational modification]; other site 251229011414 elongation factor P; Validated; Region: PRK00529 251229011415 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 251229011416 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 251229011417 RNA binding site [nucleotide binding]; other site 251229011418 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 251229011419 RNA binding site [nucleotide binding]; other site 251229011420 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 251229011421 active site 251229011422 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 251229011423 Protein of unknown function (DUF760); Region: DUF760; pfam05542 251229011424 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 251229011425 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 251229011426 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 251229011427 protein binding site [polypeptide binding]; other site 251229011428 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 251229011429 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 251229011430 Peptidase family M23; Region: Peptidase_M23; pfam01551 251229011431 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 251229011432 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 251229011433 active site 251229011434 dimer interface [polypeptide binding]; other site 251229011435 metal binding site [ion binding]; metal-binding site 251229011436 BON domain; Region: BON; pfam04972 251229011437 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 251229011438 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 251229011439 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 251229011440 Ligand Binding Site [chemical binding]; other site 251229011441 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251229011442 Ligand Binding Site [chemical binding]; other site 251229011443 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251229011444 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 251229011445 NAD binding site [chemical binding]; other site 251229011446 putative substrate binding site 2 [chemical binding]; other site 251229011447 putative substrate binding site 1 [chemical binding]; other site 251229011448 active site 251229011449 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 251229011450 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 251229011451 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 251229011452 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 251229011453 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 251229011454 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 251229011455 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 251229011456 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 251229011457 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 251229011458 MoxR-like ATPases [General function prediction only]; Region: COG0714 251229011459 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 251229011460 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 251229011461 four helix bundle protein; Region: TIGR02436 251229011462 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 251229011463 hydrophobic ligand binding site; other site 251229011464 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 251229011465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229011466 S-adenosylmethionine binding site [chemical binding]; other site 251229011467 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 251229011468 2-isopropylmalate synthase; Validated; Region: PRK00915 251229011469 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 251229011470 active site 251229011471 catalytic residues [active] 251229011472 metal binding site [ion binding]; metal-binding site 251229011473 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 251229011474 Uncharacterized conserved protein [Function unknown]; Region: COG1432 251229011475 LabA_like proteins; Region: LabA; cd10911 251229011476 putative metal binding site [ion binding]; other site 251229011477 CHASE2 domain; Region: CHASE2; pfam05226 251229011478 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229011479 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229011480 active site 251229011481 ATP binding site [chemical binding]; other site 251229011482 substrate binding site [chemical binding]; other site 251229011483 activation loop (A-loop); other site 251229011484 FecR protein; Region: FecR; pfam04773 251229011485 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 251229011486 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 251229011487 active site residue [active] 251229011488 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 251229011489 active site residue [active] 251229011490 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 251229011491 heme binding pocket [chemical binding]; other site 251229011492 heme ligand [chemical binding]; other site 251229011493 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 251229011494 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 251229011495 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 251229011496 putative C-terminal domain interface [polypeptide binding]; other site 251229011497 putative GSH binding site (G-site) [chemical binding]; other site 251229011498 putative dimer interface [polypeptide binding]; other site 251229011499 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 251229011500 N-terminal domain interface [polypeptide binding]; other site 251229011501 dimer interface [polypeptide binding]; other site 251229011502 substrate binding pocket (H-site) [chemical binding]; other site 251229011503 S-layer homology domain; Region: SLH; pfam00395 251229011504 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 251229011505 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 251229011506 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 251229011507 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 251229011508 Circadian oscillating protein COP23; Region: COP23; pfam14218 251229011509 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229011510 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229011511 active site 251229011512 ATP binding site [chemical binding]; other site 251229011513 substrate binding site [chemical binding]; other site 251229011514 activation loop (A-loop); other site 251229011515 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 251229011516 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229011517 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229011518 active site 251229011519 ATP binding site [chemical binding]; other site 251229011520 substrate binding site [chemical binding]; other site 251229011521 activation loop (A-loop); other site 251229011522 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 251229011523 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251229011524 phosphopeptide binding site; other site 251229011525 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 251229011526 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251229011527 phosphopeptide binding site; other site 251229011528 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251229011529 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 251229011530 phosphopeptide binding site; other site 251229011531 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 251229011532 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 251229011533 Walker A/P-loop; other site 251229011534 ATP binding site [chemical binding]; other site 251229011535 Q-loop/lid; other site 251229011536 ABC transporter signature motif; other site 251229011537 Walker B; other site 251229011538 D-loop; other site 251229011539 H-loop/switch region; other site 251229011540 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 251229011541 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 251229011542 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 251229011543 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 251229011544 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 251229011545 active site flap/lid [active] 251229011546 nucleophilic elbow; other site 251229011547 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229011548 putative active site [active] 251229011549 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 251229011550 DNA photolyase; Region: DNA_photolyase; pfam00875 251229011551 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 251229011552 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 251229011553 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 251229011554 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 251229011555 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229011556 dimerization interface [polypeptide binding]; other site 251229011557 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251229011558 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229011559 putative active site [active] 251229011560 heme pocket [chemical binding]; other site 251229011561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229011562 dimer interface [polypeptide binding]; other site 251229011563 phosphorylation site [posttranslational modification] 251229011564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229011565 ATP binding site [chemical binding]; other site 251229011566 Mg2+ binding site [ion binding]; other site 251229011567 G-X-G motif; other site 251229011568 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 251229011569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229011570 Coenzyme A binding pocket [chemical binding]; other site 251229011571 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 251229011572 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 251229011573 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 251229011574 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 251229011575 tetramer interface [polypeptide binding]; other site 251229011576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229011577 catalytic residue [active] 251229011578 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 251229011579 Uncharacterized conserved protein [Function unknown]; Region: COG3937 251229011580 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 251229011581 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 251229011582 replicative DNA helicase; Region: DnaB; TIGR00665 251229011583 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 251229011584 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 251229011585 Walker A motif; other site 251229011586 ATP binding site [chemical binding]; other site 251229011587 Walker B motif; other site 251229011588 DNA binding loops [nucleotide binding] 251229011589 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 251229011590 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 251229011591 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 251229011592 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 251229011593 protein I interface; other site 251229011594 D2 interface; other site 251229011595 protein T interface; other site 251229011596 chlorophyll binding site; other site 251229011597 beta carotene binding site; other site 251229011598 pheophytin binding site; other site 251229011599 manganese-stabilizing polypeptide interface; other site 251229011600 CP43 interface; other site 251229011601 protein L interface; other site 251229011602 oxygen evolving complex binding site; other site 251229011603 bromide binding site; other site 251229011604 quinone binding site; other site 251229011605 Fe binding site [ion binding]; other site 251229011606 core light harvesting interface; other site 251229011607 cytochrome b559 alpha subunit interface; other site 251229011608 cytochrome c-550 interface; other site 251229011609 protein J interface; other site 251229011610 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 251229011611 nucleotide binding site/active site [active] 251229011612 HIT family signature motif; other site 251229011613 catalytic residue [active] 251229011614 Mg chelatase-related protein; Region: TIGR00368 251229011615 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 251229011616 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 251229011617 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 251229011618 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 251229011619 DHH family; Region: DHH; pfam01368 251229011620 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 251229011621 YciI-like protein; Reviewed; Region: PRK12864 251229011622 Predicted GTPase [General function prediction only]; Region: COG3596 251229011623 YfjP GTPase; Region: YfjP; cd11383 251229011624 G1 box; other site 251229011625 GTP/Mg2+ binding site [chemical binding]; other site 251229011626 Switch I region; other site 251229011627 G2 box; other site 251229011628 Switch II region; other site 251229011629 G3 box; other site 251229011630 G4 box; other site 251229011631 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 251229011632 anti sigma factor interaction site; other site 251229011633 regulatory phosphorylation site [posttranslational modification]; other site 251229011634 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 251229011635 active site 251229011636 metal binding site [ion binding]; metal-binding site 251229011637 dimerization interface [polypeptide binding]; other site 251229011638 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 251229011639 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 251229011640 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 251229011641 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 251229011642 Stage II sporulation protein; Region: SpoIID; pfam08486 251229011643 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 251229011644 RNase_H superfamily; Region: RNase_H_2; pfam13482 251229011645 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 251229011646 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229011647 active site 251229011648 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229011649 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 251229011650 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 251229011651 putative ADP-binding pocket [chemical binding]; other site 251229011652 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 251229011653 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 251229011654 catalytic triad [active] 251229011655 ABC-2 type transporter; Region: ABC2_membrane; cl17235 251229011656 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 251229011657 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 251229011658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229011659 Walker A/P-loop; other site 251229011660 ATP binding site [chemical binding]; other site 251229011661 Q-loop/lid; other site 251229011662 ABC transporter signature motif; other site 251229011663 Walker B; other site 251229011664 D-loop; other site 251229011665 H-loop/switch region; other site 251229011666 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 251229011667 UbiA prenyltransferase family; Region: UbiA; pfam01040 251229011668 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 251229011669 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 251229011670 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 251229011671 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 251229011672 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 251229011673 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 251229011674 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 251229011675 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 251229011676 D-pathway; other site 251229011677 Putative ubiquinol binding site [chemical binding]; other site 251229011678 Low-spin heme (heme b) binding site [chemical binding]; other site 251229011679 Putative water exit pathway; other site 251229011680 Binuclear center (heme o3/CuB) [ion binding]; other site 251229011681 K-pathway; other site 251229011682 Putative proton exit pathway; other site 251229011683 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 251229011684 Subunit I/III interface [polypeptide binding]; other site 251229011685 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 251229011686 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 251229011687 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 251229011688 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 251229011689 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 251229011690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229011691 homodimer interface [polypeptide binding]; other site 251229011692 catalytic residue [active] 251229011693 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 251229011694 IHF dimer interface [polypeptide binding]; other site 251229011695 IHF - DNA interface [nucleotide binding]; other site 251229011696 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 251229011697 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 251229011698 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 251229011699 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 251229011700 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 251229011701 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 251229011702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229011703 Walker A/P-loop; other site 251229011704 ATP binding site [chemical binding]; other site 251229011705 Q-loop/lid; other site 251229011706 ABC transporter signature motif; other site 251229011707 Walker B; other site 251229011708 D-loop; other site 251229011709 H-loop/switch region; other site 251229011710 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 251229011711 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 251229011712 catalytic motif [active] 251229011713 Zn binding site [ion binding]; other site 251229011714 RibD C-terminal domain; Region: RibD_C; cl17279 251229011715 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 251229011716 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 251229011717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229011718 homodimer interface [polypeptide binding]; other site 251229011719 catalytic residue [active] 251229011720 rod shape-determining protein MreD; Region: MreD; cl01087 251229011721 rod shape-determining protein MreC; Provisional; Region: PRK13922 251229011722 rod shape-determining protein MreC; Region: MreC; pfam04085 251229011723 rod shape-determining protein MreB; Provisional; Region: PRK13927 251229011724 MreB and similar proteins; Region: MreB_like; cd10225 251229011725 nucleotide binding site [chemical binding]; other site 251229011726 Mg binding site [ion binding]; other site 251229011727 putative protofilament interaction site [polypeptide binding]; other site 251229011728 RodZ interaction site [polypeptide binding]; other site 251229011729 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 251229011730 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 251229011731 dimer interface [polypeptide binding]; other site 251229011732 ssDNA binding site [nucleotide binding]; other site 251229011733 tetramer (dimer of dimers) interface [polypeptide binding]; other site 251229011734 Uncharacterized conserved protein [Function unknown]; Region: COG2968 251229011735 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 251229011736 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 251229011737 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 251229011738 transmembrane helices; other site 251229011739 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 251229011740 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 251229011741 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 251229011742 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 251229011743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229011744 motif II; other site 251229011745 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 251229011746 recombination protein F; Reviewed; Region: recF; PRK00064 251229011747 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 251229011748 Walker A/P-loop; other site 251229011749 ATP binding site [chemical binding]; other site 251229011750 Q-loop/lid; other site 251229011751 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229011752 ABC transporter signature motif; other site 251229011753 Walker B; other site 251229011754 D-loop; other site 251229011755 H-loop/switch region; other site 251229011756 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 251229011757 MgtC family; Region: MgtC; pfam02308 251229011758 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 251229011759 active site 251229011760 catalytic residues [active] 251229011761 Family of unknown function (DUF490); Region: DUF490; pfam04357 251229011762 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 251229011763 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 251229011764 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 251229011765 putative active site [active] 251229011766 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 251229011767 Peptidase family M50; Region: Peptidase_M50; pfam02163 251229011768 active site 251229011769 putative substrate binding region [chemical binding]; other site 251229011770 Predicted helicase [General function prediction only]; Region: COG4889 251229011771 Methyltransferase domain; Region: Methyltransf_26; pfam13659 251229011772 Dynamin family; Region: Dynamin_N; pfam00350 251229011773 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 251229011774 G1 box; other site 251229011775 GTP/Mg2+ binding site [chemical binding]; other site 251229011776 G2 box; other site 251229011777 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 251229011778 G3 box; other site 251229011779 Switch II region; other site 251229011780 GTP/Mg2+ binding site [chemical binding]; other site 251229011781 G4 box; other site 251229011782 G5 box; other site 251229011783 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 251229011784 Bacterial Ig-like domain; Region: Big_5; pfam13205 251229011785 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 251229011786 four helix bundle protein; Region: TIGR02436 251229011787 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 251229011788 chorismate binding enzyme; Region: Chorismate_bind; cl10555 251229011789 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 251229011790 UbiA prenyltransferase family; Region: UbiA; pfam01040 251229011791 O-succinylbenzoate synthase; Provisional; Region: PRK02714 251229011792 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 251229011793 active site 251229011794 O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445 251229011795 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 251229011796 acyl-activating enzyme (AAE) consensus motif; other site 251229011797 putative AMP binding site [chemical binding]; other site 251229011798 putative active site [active] 251229011799 putative CoA binding site [chemical binding]; other site 251229011800 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 251229011801 active site 251229011802 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 251229011803 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 251229011804 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229011805 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 251229011806 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 251229011807 iron-sulfur cluster [ion binding]; other site 251229011808 [2Fe-2S] cluster binding site [ion binding]; other site 251229011809 Uncharacterized conserved protein [Function unknown]; Region: COG3349 251229011810 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 251229011811 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 251229011812 iron-sulfur cluster [ion binding]; other site 251229011813 [2Fe-2S] cluster binding site [ion binding]; other site 251229011814 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 251229011815 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 251229011816 dimer interface [polypeptide binding]; other site 251229011817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229011818 catalytic residue [active] 251229011819 HEAT repeats; Region: HEAT_2; pfam13646 251229011820 HEAT repeats; Region: HEAT_2; pfam13646 251229011821 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229011822 PAS fold; Region: PAS_3; pfam08447 251229011823 putative active site [active] 251229011824 heme pocket [chemical binding]; other site 251229011825 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229011826 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229011827 metal binding site [ion binding]; metal-binding site 251229011828 active site 251229011829 I-site; other site 251229011830 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 251229011831 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 251229011832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229011833 putative substrate translocation pore; other site 251229011834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229011835 TPR repeat; Region: TPR_11; pfam13414 251229011836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229011837 binding surface 251229011838 TPR motif; other site 251229011839 TPR repeat; Region: TPR_11; pfam13414 251229011840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229011841 TPR motif; other site 251229011842 TPR repeat; Region: TPR_11; pfam13414 251229011843 binding surface 251229011844 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 251229011845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229011846 Walker A/P-loop; other site 251229011847 ATP binding site [chemical binding]; other site 251229011848 Q-loop/lid; other site 251229011849 ABC transporter signature motif; other site 251229011850 Walker B; other site 251229011851 D-loop; other site 251229011852 H-loop/switch region; other site 251229011853 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 251229011854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229011855 putative substrate translocation pore; other site 251229011856 Response regulator receiver domain; Region: Response_reg; pfam00072 251229011857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229011858 active site 251229011859 phosphorylation site [posttranslational modification] 251229011860 intermolecular recognition site; other site 251229011861 dimerization interface [polypeptide binding]; other site 251229011862 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229011863 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229011864 metal binding site [ion binding]; metal-binding site 251229011865 active site 251229011866 I-site; other site 251229011867 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 251229011868 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 251229011869 N-acetyl-D-glucosamine binding site [chemical binding]; other site 251229011870 catalytic residue [active] 251229011871 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 251229011872 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 251229011873 ATP binding site [chemical binding]; other site 251229011874 putative Mg++ binding site [ion binding]; other site 251229011875 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 251229011876 Dihaem cytochrome c; Region: DHC; pfam09626 251229011877 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 251229011878 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 251229011879 4Fe-4S binding domain; Region: Fer4; pfam00037 251229011880 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 251229011881 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 251229011882 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 251229011883 catalytic residues [active] 251229011884 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 251229011885 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 251229011886 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 251229011887 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 251229011888 putative C-terminal domain interface [polypeptide binding]; other site 251229011889 putative GSH binding site (G-site) [chemical binding]; other site 251229011890 putative dimer interface [polypeptide binding]; other site 251229011891 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 251229011892 putative N-terminal domain interface [polypeptide binding]; other site 251229011893 putative dimer interface [polypeptide binding]; other site 251229011894 putative substrate binding pocket (H-site) [chemical binding]; other site 251229011895 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251229011896 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 251229011897 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 251229011898 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 251229011899 dimerization interface [polypeptide binding]; other site 251229011900 active site 251229011901 metal binding site [ion binding]; metal-binding site 251229011902 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 251229011903 dsRNA binding site [nucleotide binding]; other site 251229011904 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 251229011905 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 251229011906 catalytic site [active] 251229011907 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 251229011908 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 251229011909 heme bL binding site [chemical binding]; other site 251229011910 interchain domain interface [polypeptide binding]; other site 251229011911 intrachain domain interface; other site 251229011912 heme bH binding site [chemical binding]; other site 251229011913 Qo binding site; other site 251229011914 S-formylglutathione hydrolase; Region: PLN02442 251229011915 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 251229011916 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 251229011917 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 251229011918 inhibitor-cofactor binding pocket; inhibition site 251229011919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229011920 catalytic residue [active] 251229011921 Domain of unknown function DUF21; Region: DUF21; pfam01595 251229011922 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 251229011923 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 251229011924 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 251229011925 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 251229011926 NAD binding site [chemical binding]; other site 251229011927 catalytic residues [active] 251229011928 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229011929 RDD family; Region: RDD; pfam06271 251229011930 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 251229011931 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229011932 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229011933 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229011934 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229011935 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229011936 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229011937 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 251229011938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 251229011939 ATP binding site [chemical binding]; other site 251229011940 Mg2+ binding site [ion binding]; other site 251229011941 G-X-G motif; other site 251229011942 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 251229011943 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 251229011944 interchain domain interface [polypeptide binding]; other site 251229011945 intrachain domain interface; other site 251229011946 Qi binding site; other site 251229011947 Qo binding site; other site 251229011948 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 251229011949 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 251229011950 Qi binding site; other site 251229011951 intrachain domain interface; other site 251229011952 interchain domain interface [polypeptide binding]; other site 251229011953 heme bH binding site [chemical binding]; other site 251229011954 heme bL binding site [chemical binding]; other site 251229011955 Qo binding site; other site 251229011956 carboxyl-terminal processing protease; Provisional; Region: PLN00049 251229011957 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 251229011958 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 251229011959 protein binding site [polypeptide binding]; other site 251229011960 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 251229011961 Catalytic dyad [active] 251229011962 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 251229011963 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 251229011964 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 251229011965 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 251229011966 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 251229011967 Walker A/P-loop; other site 251229011968 ATP binding site [chemical binding]; other site 251229011969 Q-loop/lid; other site 251229011970 ABC transporter signature motif; other site 251229011971 Walker B; other site 251229011972 D-loop; other site 251229011973 H-loop/switch region; other site 251229011974 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 251229011975 DHH family; Region: DHH; pfam01368 251229011976 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 251229011977 FOG: CBS domain [General function prediction only]; Region: COG0517 251229011978 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 251229011979 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 251229011980 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 251229011981 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 251229011982 active site 251229011983 NTP binding site [chemical binding]; other site 251229011984 metal binding triad [ion binding]; metal-binding site 251229011985 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 251229011986 photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576 251229011987 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 251229011988 homopentamer interface [polypeptide binding]; other site 251229011989 active site 251229011990 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 251229011991 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 251229011992 putative catalytic cysteine [active] 251229011993 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 251229011994 Di-iron ligands [ion binding]; other site 251229011995 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 251229011996 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 251229011997 Aluminium resistance protein; Region: Alum_res; pfam06838 251229011998 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 251229011999 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 251229012000 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 251229012001 DNA methylase; Region: N6_N4_Mtase; pfam01555 251229012002 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 251229012003 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 251229012004 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 251229012005 ligand binding site [chemical binding]; other site 251229012006 CHASE domain; Region: CHASE; pfam03924 251229012007 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229012008 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 251229012009 putative active site [active] 251229012010 heme pocket [chemical binding]; other site 251229012011 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229012012 putative active site [active] 251229012013 heme pocket [chemical binding]; other site 251229012014 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 251229012015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229012016 dimer interface [polypeptide binding]; other site 251229012017 phosphorylation site [posttranslational modification] 251229012018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229012019 ATP binding site [chemical binding]; other site 251229012020 Mg2+ binding site [ion binding]; other site 251229012021 G-X-G motif; other site 251229012022 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229012023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229012024 active site 251229012025 phosphorylation site [posttranslational modification] 251229012026 intermolecular recognition site; other site 251229012027 dimerization interface [polypeptide binding]; other site 251229012028 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 251229012029 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251229012030 ATP binding site [chemical binding]; other site 251229012031 putative Mg++ binding site [ion binding]; other site 251229012032 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251229012033 nucleotide binding region [chemical binding]; other site 251229012034 ATP-binding site [chemical binding]; other site 251229012035 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 251229012036 Protein of unknown function (DUF790); Region: DUF790; pfam05626 251229012037 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 251229012038 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 251229012039 DNA-binding site [nucleotide binding]; DNA binding site 251229012040 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 251229012041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229012042 homodimer interface [polypeptide binding]; other site 251229012043 catalytic residue [active] 251229012044 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229012045 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229012046 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229012047 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229012048 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229012049 putative active site [active] 251229012050 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 251229012051 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 251229012052 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 251229012053 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 251229012054 Mg++ binding site [ion binding]; other site 251229012055 putative catalytic motif [active] 251229012056 putative substrate binding site [chemical binding]; other site 251229012057 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 251229012058 MPT binding site; other site 251229012059 trimer interface [polypeptide binding]; other site 251229012060 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 251229012061 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 251229012062 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 251229012063 TPR repeat; Region: TPR_11; pfam13414 251229012064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229012065 binding surface 251229012066 TPR motif; other site 251229012067 TPR repeat; Region: TPR_11; pfam13414 251229012068 TPR repeat; Region: TPR_11; pfam13414 251229012069 TPR repeat; Region: TPR_11; pfam13414 251229012070 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229012071 binding surface 251229012072 TPR motif; other site 251229012073 TPR repeat; Region: TPR_11; pfam13414 251229012074 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 251229012075 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 251229012076 Circadian oscillating protein COP23; Region: COP23; pfam14218 251229012077 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229012078 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229012079 active site 251229012080 ATP binding site [chemical binding]; other site 251229012081 substrate binding site [chemical binding]; other site 251229012082 activation loop (A-loop); other site 251229012083 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 251229012084 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 251229012085 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 251229012086 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 251229012087 TPP-binding site; other site 251229012088 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 251229012089 PYR/PP interface [polypeptide binding]; other site 251229012090 dimer interface [polypeptide binding]; other site 251229012091 TPP binding site [chemical binding]; other site 251229012092 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 251229012093 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 251229012094 cobalamin synthase; Reviewed; Region: cobS; PRK00235 251229012095 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 251229012096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229012097 Walker A motif; other site 251229012098 ATP binding site [chemical binding]; other site 251229012099 Walker B motif; other site 251229012100 arginine finger; other site 251229012101 Peptidase family M41; Region: Peptidase_M41; pfam01434 251229012102 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 251229012103 EamA-like transporter family; Region: EamA; pfam00892 251229012104 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 251229012105 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 251229012106 homodimer interface [polypeptide binding]; other site 251229012107 substrate-cofactor binding pocket; other site 251229012108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229012109 catalytic residue [active] 251229012110 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 251229012111 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 251229012112 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 251229012113 Na binding site [ion binding]; other site 251229012114 TPR repeat; Region: TPR_11; pfam13414 251229012115 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229012116 binding surface 251229012117 TPR motif; other site 251229012118 TPR repeat; Region: TPR_11; pfam13414 251229012119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229012120 binding surface 251229012121 TPR motif; other site 251229012122 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 251229012123 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 251229012124 active site 251229012125 catalytic residues [active] 251229012126 metal binding site [ion binding]; metal-binding site 251229012127 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 251229012128 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 251229012129 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251229012130 catalytic loop [active] 251229012131 iron binding site [ion binding]; other site 251229012132 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 251229012133 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 251229012134 ThiS interaction site; other site 251229012135 putative active site [active] 251229012136 tetramer interface [polypeptide binding]; other site 251229012137 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 251229012138 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 251229012139 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 251229012140 ligand binding site [chemical binding]; other site 251229012141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229012142 putative PBP binding loops; other site 251229012143 dimer interface [polypeptide binding]; other site 251229012144 ABC-ATPase subunit interface; other site 251229012145 putative transporter; Provisional; Region: PRK10484 251229012146 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 251229012147 Na binding site [ion binding]; other site 251229012148 S-layer homology domain; Region: SLH; pfam00395 251229012149 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251229012150 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 251229012151 FAD binding domain; Region: FAD_binding_4; pfam01565 251229012152 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 251229012153 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 251229012154 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 251229012155 Walker A/P-loop; other site 251229012156 ATP binding site [chemical binding]; other site 251229012157 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 251229012158 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 251229012159 ABC transporter signature motif; other site 251229012160 Walker B; other site 251229012161 D-loop; other site 251229012162 H-loop/switch region; other site 251229012163 PRC-barrel domain; Region: PRC; pfam05239 251229012164 PRC-barrel domain; Region: PRC; pfam05239 251229012165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229012166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229012167 dimer interface [polypeptide binding]; other site 251229012168 phosphorylation site [posttranslational modification] 251229012169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229012170 ATP binding site [chemical binding]; other site 251229012171 Mg2+ binding site [ion binding]; other site 251229012172 G-X-G motif; other site 251229012173 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 251229012174 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 251229012175 trimer interface [polypeptide binding]; other site 251229012176 active site 251229012177 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 251229012178 proton extrusion protein PcxA; Provisional; Region: PRK02507 251229012179 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 251229012180 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229012181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229012182 active site 251229012183 phosphorylation site [posttranslational modification] 251229012184 intermolecular recognition site; other site 251229012185 dimerization interface [polypeptide binding]; other site 251229012186 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229012187 DNA binding site [nucleotide binding] 251229012188 Response regulator receiver domain; Region: Response_reg; pfam00072 251229012189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229012190 active site 251229012191 phosphorylation site [posttranslational modification] 251229012192 intermolecular recognition site; other site 251229012193 dimerization interface [polypeptide binding]; other site 251229012194 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 251229012195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229012196 Response regulator receiver domain; Region: Response_reg; pfam00072 251229012197 active site 251229012198 phosphorylation site [posttranslational modification] 251229012199 intermolecular recognition site; other site 251229012200 dimerization interface [polypeptide binding]; other site 251229012201 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 251229012202 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229012203 dimerization interface [polypeptide binding]; other site 251229012204 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229012205 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229012206 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 251229012207 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 251229012208 dimer interface [polypeptide binding]; other site 251229012209 putative CheW interface [polypeptide binding]; other site 251229012210 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 251229012211 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 251229012212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229012213 Walker A motif; other site 251229012214 ATP binding site [chemical binding]; other site 251229012215 Walker B motif; other site 251229012216 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 251229012217 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251229012218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229012219 ATP binding site [chemical binding]; other site 251229012220 Mg2+ binding site [ion binding]; other site 251229012221 G-X-G motif; other site 251229012222 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 251229012223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 251229012224 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 251229012225 Predicted membrane protein [Function unknown]; Region: COG3686 251229012226 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 251229012227 Predicted transcriptional regulators [Transcription]; Region: COG1695 251229012228 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 251229012229 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 251229012230 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 251229012231 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 251229012232 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 251229012233 DRTGG domain; Region: DRTGG; pfam07085 251229012234 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 251229012235 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 251229012236 RNase E interface [polypeptide binding]; other site 251229012237 trimer interface [polypeptide binding]; other site 251229012238 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 251229012239 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 251229012240 RNase E interface [polypeptide binding]; other site 251229012241 trimer interface [polypeptide binding]; other site 251229012242 active site 251229012243 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 251229012244 putative nucleic acid binding region [nucleotide binding]; other site 251229012245 G-X-X-G motif; other site 251229012246 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 251229012247 RNA binding site [nucleotide binding]; other site 251229012248 domain interface; other site 251229012249 MASE1; Region: MASE1; cl17823 251229012250 PAS domain S-box; Region: sensory_box; TIGR00229 251229012251 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229012252 putative active site [active] 251229012253 heme pocket [chemical binding]; other site 251229012254 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229012255 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229012256 metal binding site [ion binding]; metal-binding site 251229012257 active site 251229012258 I-site; other site 251229012259 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 251229012260 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 251229012261 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 251229012262 putative active site pocket [active] 251229012263 dimerization interface [polypeptide binding]; other site 251229012264 putative catalytic residue [active] 251229012265 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 251229012266 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 251229012267 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 251229012268 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 251229012269 NAD binding site [chemical binding]; other site 251229012270 homodimer interface [polypeptide binding]; other site 251229012271 active site 251229012272 substrate binding site [chemical binding]; other site 251229012273 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 251229012274 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229012275 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229012276 PAS fold; Region: PAS_4; pfam08448 251229012277 PAS fold; Region: PAS_4; pfam08448 251229012278 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229012279 putative active site [active] 251229012280 heme pocket [chemical binding]; other site 251229012281 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229012282 GAF domain; Region: GAF; pfam01590 251229012283 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229012284 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229012285 dimer interface [polypeptide binding]; other site 251229012286 phosphorylation site [posttranslational modification] 251229012287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229012288 ATP binding site [chemical binding]; other site 251229012289 Mg2+ binding site [ion binding]; other site 251229012290 G-X-G motif; other site 251229012291 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229012292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229012293 active site 251229012294 phosphorylation site [posttranslational modification] 251229012295 intermolecular recognition site; other site 251229012296 dimerization interface [polypeptide binding]; other site 251229012297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229012298 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 251229012299 NAD(P) binding site [chemical binding]; other site 251229012300 active site 251229012301 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229012302 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229012303 active site 251229012304 ATP binding site [chemical binding]; other site 251229012305 substrate binding site [chemical binding]; other site 251229012306 activation loop (A-loop); other site 251229012307 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229012308 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229012309 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229012310 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 251229012311 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 251229012312 putative tRNA-binding site [nucleotide binding]; other site 251229012313 B3/4 domain; Region: B3_4; pfam03483 251229012314 tRNA synthetase B5 domain; Region: B5; smart00874 251229012315 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 251229012316 dimer interface [polypeptide binding]; other site 251229012317 motif 1; other site 251229012318 motif 3; other site 251229012319 motif 2; other site 251229012320 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 251229012321 guanine deaminase; Provisional; Region: PRK09228 251229012322 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 251229012323 active site 251229012324 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 251229012325 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 251229012326 Walker A/P-loop; other site 251229012327 ATP binding site [chemical binding]; other site 251229012328 Q-loop/lid; other site 251229012329 ABC transporter signature motif; other site 251229012330 Walker B; other site 251229012331 D-loop; other site 251229012332 H-loop/switch region; other site 251229012333 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 251229012334 Transglutaminase/protease-like homologues; Region: TGc; smart00460 251229012335 Response regulator receiver domain; Region: Response_reg; pfam00072 251229012336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229012337 active site 251229012338 phosphorylation site [posttranslational modification] 251229012339 intermolecular recognition site; other site 251229012340 dimerization interface [polypeptide binding]; other site 251229012341 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229012342 GAF domain; Region: GAF; pfam01590 251229012343 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229012344 Phytochrome region; Region: PHY; pfam00360 251229012345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229012346 dimer interface [polypeptide binding]; other site 251229012347 phosphorylation site [posttranslational modification] 251229012348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229012349 ATP binding site [chemical binding]; other site 251229012350 Mg2+ binding site [ion binding]; other site 251229012351 G-X-G motif; other site 251229012352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229012353 active site 251229012354 phosphorylation site [posttranslational modification] 251229012355 intermolecular recognition site; other site 251229012356 dimerization interface [polypeptide binding]; other site 251229012357 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 251229012358 active site 251229012359 dimer interface [polypeptide binding]; other site 251229012360 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 251229012361 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 251229012362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251229012363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 251229012364 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 251229012365 homotrimer interaction site [polypeptide binding]; other site 251229012366 putative active site [active] 251229012367 Cupin domain; Region: Cupin_2; cl17218 251229012368 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251229012369 Ligand Binding Site [chemical binding]; other site 251229012370 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 251229012371 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 251229012372 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 251229012373 dimer interface [polypeptide binding]; other site 251229012374 active site 251229012375 heme binding site [chemical binding]; other site 251229012376 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 251229012377 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 251229012378 DNA binding site [nucleotide binding] 251229012379 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 251229012380 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 251229012381 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 251229012382 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 251229012383 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 251229012384 Soluble P-type ATPase [General function prediction only]; Region: COG4087 251229012385 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 251229012386 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 251229012387 active site 251229012388 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 251229012389 alpha-glucosidase; Provisional; Region: PRK10137 251229012390 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 251229012391 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 251229012392 PLD-like domain; Region: PLDc_2; pfam13091 251229012393 putative active site [active] 251229012394 catalytic site [active] 251229012395 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 251229012396 PLD-like domain; Region: PLDc_2; pfam13091 251229012397 putative active site [active] 251229012398 catalytic site [active] 251229012399 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 251229012400 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229012401 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229012402 glucose-1-dehydrogenase; Provisional; Region: PRK08936 251229012403 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 251229012404 NAD binding site [chemical binding]; other site 251229012405 homodimer interface [polypeptide binding]; other site 251229012406 active site 251229012407 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 251229012408 Fasciclin domain; Region: Fasciclin; pfam02469 251229012409 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229012410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229012411 S-adenosylmethionine binding site [chemical binding]; other site 251229012412 Amino acid permease; Region: AA_permease; pfam00324 251229012413 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229012414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229012415 S-adenosylmethionine binding site [chemical binding]; other site 251229012416 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 251229012417 MgtE intracellular N domain; Region: MgtE_N; smart00924 251229012418 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 251229012419 Divalent cation transporter; Region: MgtE; pfam01769 251229012420 Membrane protein of unknown function; Region: DUF360; pfam04020 251229012421 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 251229012422 Response regulator receiver domain; Region: Response_reg; pfam00072 251229012423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229012424 active site 251229012425 phosphorylation site [posttranslational modification] 251229012426 intermolecular recognition site; other site 251229012427 dimerization interface [polypeptide binding]; other site 251229012428 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229012429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229012430 active site 251229012431 phosphorylation site [posttranslational modification] 251229012432 intermolecular recognition site; other site 251229012433 dimerization interface [polypeptide binding]; other site 251229012434 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229012435 DNA binding site [nucleotide binding] 251229012436 Response regulator receiver domain; Region: Response_reg; pfam00072 251229012437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229012438 active site 251229012439 phosphorylation site [posttranslational modification] 251229012440 intermolecular recognition site; other site 251229012441 dimerization interface [polypeptide binding]; other site 251229012442 Response regulator receiver domain; Region: Response_reg; pfam00072 251229012443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229012444 active site 251229012445 phosphorylation site [posttranslational modification] 251229012446 intermolecular recognition site; other site 251229012447 dimerization interface [polypeptide binding]; other site 251229012448 CHASE3 domain; Region: CHASE3; pfam05227 251229012449 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 251229012450 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251229012451 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229012452 putative active site [active] 251229012453 heme pocket [chemical binding]; other site 251229012454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229012455 dimer interface [polypeptide binding]; other site 251229012456 phosphorylation site [posttranslational modification] 251229012457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229012458 ATP binding site [chemical binding]; other site 251229012459 Mg2+ binding site [ion binding]; other site 251229012460 G-X-G motif; other site 251229012461 Response regulator receiver domain; Region: Response_reg; pfam00072 251229012462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229012463 active site 251229012464 phosphorylation site [posttranslational modification] 251229012465 intermolecular recognition site; other site 251229012466 dimerization interface [polypeptide binding]; other site 251229012467 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 251229012468 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 251229012469 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 251229012470 FAD binding pocket [chemical binding]; other site 251229012471 FAD binding motif [chemical binding]; other site 251229012472 phosphate binding motif [ion binding]; other site 251229012473 beta-alpha-beta structure motif; other site 251229012474 NAD binding pocket [chemical binding]; other site 251229012475 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 251229012476 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 251229012477 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 251229012478 Predicted membrane protein [Function unknown]; Region: COG1950 251229012479 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 251229012480 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 251229012481 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 251229012482 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 251229012483 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 251229012484 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 251229012485 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 251229012486 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 251229012487 Bacteriorhodopsin [General function prediction only]; Region: COG5524 251229012488 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 251229012489 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 251229012490 Domain of unknown function DUF20; Region: UPF0118; pfam01594 251229012491 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 251229012492 Predicted membrane protein [Function unknown]; Region: COG1808 251229012493 Peptidase family M48; Region: Peptidase_M48; cl12018 251229012494 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 251229012495 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 251229012496 TPR repeat; Region: TPR_11; pfam13414 251229012497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229012498 binding surface 251229012499 TPR motif; other site 251229012500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229012501 binding surface 251229012502 TPR repeat; Region: TPR_11; pfam13414 251229012503 TPR motif; other site 251229012504 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 251229012505 core domain interface [polypeptide binding]; other site 251229012506 delta subunit interface [polypeptide binding]; other site 251229012507 epsilon subunit interface [polypeptide binding]; other site 251229012508 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 251229012509 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 251229012510 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 251229012511 beta subunit interaction interface [polypeptide binding]; other site 251229012512 Walker A motif; other site 251229012513 ATP binding site [chemical binding]; other site 251229012514 Walker B motif; other site 251229012515 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 251229012516 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 251229012517 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 251229012518 ATP synthase CF0 B subunit; Region: atpF; CHL00019 251229012519 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 251229012520 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 251229012521 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 251229012522 ATP synthase CF0 C subunit; Region: atpH; CHL00061 251229012523 ATP synthase CF0 A subunit; Region: atpI; CHL00046 251229012524 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 251229012525 ATP synthase I chain; Region: ATP_synt_I; pfam03899 251229012526 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229012527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229012528 S-adenosylmethionine binding site [chemical binding]; other site 251229012529 Protein of unknown function (DUF497); Region: DUF497; cl01108 251229012530 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 251229012531 PemK-like protein; Region: PemK; pfam02452 251229012532 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 251229012533 putative active site [active] 251229012534 Uncharacterized small protein [Function unknown]; Region: COG2886 251229012535 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 251229012536 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 251229012537 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229012538 putative active site [active] 251229012539 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229012540 putative active site [active] 251229012541 phycobillisome linker protein; Region: apcE; CHL00091 251229012542 Phycobilisome protein; Region: Phycobilisome; cl08227 251229012543 Phycobilisome protein; Region: Phycobilisome; cl08227 251229012544 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251229012545 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251229012546 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251229012547 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 251229012548 Phycobilisome protein; Region: Phycobilisome; cl08227 251229012549 Phycobilisome protein; Region: Phycobilisome; cl08227 251229012550 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 251229012551 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 251229012552 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 251229012553 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 251229012554 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 251229012555 c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177 251229012556 ResB-like family; Region: ResB; pfam05140 251229012557 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 251229012558 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229012559 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229012560 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 251229012561 Uncharacterized conserved protein [Function unknown]; Region: COG3937 251229012562 YCII-related domain; Region: YCII; cl00999 251229012563 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 251229012564 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 251229012565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 251229012566 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 251229012567 protein I interface; other site 251229012568 D2 interface; other site 251229012569 protein T interface; other site 251229012570 chlorophyll binding site; other site 251229012571 beta carotene binding site; other site 251229012572 pheophytin binding site; other site 251229012573 manganese-stabilizing polypeptide interface; other site 251229012574 CP43 interface; other site 251229012575 protein L interface; other site 251229012576 oxygen evolving complex binding site; other site 251229012577 bromide binding site; other site 251229012578 quinone binding site; other site 251229012579 Fe binding site [ion binding]; other site 251229012580 core light harvesting interface; other site 251229012581 cytochrome b559 alpha subunit interface; other site 251229012582 cytochrome c-550 interface; other site 251229012583 protein J interface; other site 251229012584 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 251229012585 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251229012586 FeS/SAM binding site; other site 251229012587 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 251229012588 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 251229012589 HflX GTPase family; Region: HflX; cd01878 251229012590 G1 box; other site 251229012591 GTP/Mg2+ binding site [chemical binding]; other site 251229012592 Switch I region; other site 251229012593 G2 box; other site 251229012594 G3 box; other site 251229012595 Switch II region; other site 251229012596 G4 box; other site 251229012597 G5 box; other site 251229012598 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 251229012599 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 251229012600 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 251229012601 Probable Catalytic site; other site 251229012602 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 251229012603 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 251229012604 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 251229012605 putative active site [active] 251229012606 Double zinc ribbon; Region: DZR; pfam12773 251229012607 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 251229012608 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 251229012609 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251229012610 phosphopeptide binding site; other site 251229012611 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 251229012612 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251229012613 phosphopeptide binding site; other site 251229012614 DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191 251229012615 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 251229012616 NADH(P)-binding; Region: NAD_binding_10; pfam13460 251229012617 NAD(P) binding site [chemical binding]; other site 251229012618 putative active site [active] 251229012619 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 251229012620 GTP binding site; other site 251229012621 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 251229012622 CHASE4 domain; Region: CHASE4; cl01308 251229012623 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229012624 dimerization interface [polypeptide binding]; other site 251229012625 PAS domain; Region: PAS_9; pfam13426 251229012626 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229012627 PAS domain; Region: PAS_9; pfam13426 251229012628 putative active site [active] 251229012629 heme pocket [chemical binding]; other site 251229012630 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229012631 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229012632 metal binding site [ion binding]; metal-binding site 251229012633 active site 251229012634 I-site; other site 251229012635 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 251229012636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229012637 S-adenosylmethionine binding site [chemical binding]; other site 251229012638 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 251229012639 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 251229012640 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229012641 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 251229012642 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 251229012643 CsbD-like; Region: CsbD; cl17424 251229012644 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 251229012645 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 251229012646 FMN binding site [chemical binding]; other site 251229012647 active site 251229012648 catalytic residues [active] 251229012649 substrate binding site [chemical binding]; other site 251229012650 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 251229012651 Phycobilisome protein; Region: Phycobilisome; cl08227 251229012652 Phycobilisome protein; Region: Phycobilisome; cl08227 251229012653 Predicted helicase [General function prediction only]; Region: COG4889 251229012654 Methyltransferase domain; Region: Methyltransf_26; pfam13659 251229012655 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 251229012656 YcfA-like protein; Region: YcfA; cl00752 251229012657 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 251229012658 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 251229012659 HIGH motif; other site 251229012660 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 251229012661 active site 251229012662 KMSKS motif; other site 251229012663 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 251229012664 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 251229012665 active site 251229012666 catalytic tetrad [active] 251229012667 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 251229012668 G1 box; other site 251229012669 GTP/Mg2+ binding site [chemical binding]; other site 251229012670 G2 box; other site 251229012671 Switch I region; other site 251229012672 G3 box; other site 251229012673 Switch II region; other site 251229012674 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 251229012675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229012676 S-adenosylmethionine binding site [chemical binding]; other site 251229012677 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 251229012678 PemK-like protein; Region: PemK; pfam02452 251229012679 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 251229012680 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 251229012681 putative NAD(P) binding site [chemical binding]; other site 251229012682 active site 251229012683 prephenate dehydratase; Provisional; Region: PRK11898 251229012684 Prephenate dehydratase; Region: PDT; pfam00800 251229012685 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 251229012686 putative L-Phe binding site [chemical binding]; other site 251229012687 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 251229012688 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 251229012689 RNA/DNA hybrid binding site [nucleotide binding]; other site 251229012690 active site 251229012691 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 251229012692 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 251229012693 homodimer interface [polypeptide binding]; other site 251229012694 oligonucleotide binding site [chemical binding]; other site 251229012695 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 251229012696 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 251229012697 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251229012698 FeS/SAM binding site; other site 251229012699 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 251229012700 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 251229012701 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 251229012702 anti sigma factor interaction site; other site 251229012703 regulatory phosphorylation site [posttranslational modification]; other site 251229012704 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 251229012705 CAAX protease self-immunity; Region: Abi; pfam02517 251229012706 Utp8 family; Region: Utp8; pfam10395 251229012707 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 251229012708 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251229012709 active site 251229012710 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 251229012711 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 251229012712 inhibitor-cofactor binding pocket; inhibition site 251229012713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229012714 catalytic residue [active] 251229012715 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229012716 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229012717 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229012718 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229012719 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229012720 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 251229012721 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 251229012722 HD domain; Region: HD_5; pfam13487 251229012723 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 251229012724 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251229012725 FeS/SAM binding site; other site 251229012726 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 251229012727 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 251229012728 ferredoxin-sulfite reductase; Region: sir; TIGR02042 251229012729 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 251229012730 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 251229012731 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 251229012732 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 251229012733 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 251229012734 endonuclease III; Region: ENDO3c; smart00478 251229012735 minor groove reading motif; other site 251229012736 helix-hairpin-helix signature motif; other site 251229012737 substrate binding pocket [chemical binding]; other site 251229012738 active site 251229012739 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 251229012740 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 251229012741 DNA-binding interface [nucleotide binding]; DNA binding site 251229012742 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 251229012743 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 251229012744 active site 251229012745 (T/H)XGH motif; other site 251229012746 Domain of unknown function DUF20; Region: UPF0118; pfam01594 251229012747 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 251229012748 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 251229012749 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 251229012750 active site 251229012751 HIGH motif; other site 251229012752 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 251229012753 KMSKS motif; other site 251229012754 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 251229012755 tRNA binding surface [nucleotide binding]; other site 251229012756 anticodon binding site; other site 251229012757 Dynamin family; Region: Dynamin_N; pfam00350 251229012758 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 251229012759 G1 box; other site 251229012760 GTP/Mg2+ binding site [chemical binding]; other site 251229012761 Switch I region; other site 251229012762 G2 box; other site 251229012763 Switch II region; other site 251229012764 G3 box; other site 251229012765 G4 box; other site 251229012766 Domain of unknown function (DUF697); Region: DUF697; pfam05128 251229012767 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 251229012768 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 251229012769 dimer interface [polypeptide binding]; other site 251229012770 Acylphosphatase; Region: Acylphosphatase; pfam00708 251229012771 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 251229012772 HypF finger; Region: zf-HYPF; pfam07503 251229012773 HypF finger; Region: zf-HYPF; pfam07503 251229012774 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 251229012775 HupF/HypC family; Region: HupF_HypC; pfam01455 251229012776 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 251229012777 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 251229012778 dimer interface [polypeptide binding]; other site 251229012779 PYR/PP interface [polypeptide binding]; other site 251229012780 TPP binding site [chemical binding]; other site 251229012781 substrate binding site [chemical binding]; other site 251229012782 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 251229012783 Domain of unknown function; Region: EKR; pfam10371 251229012784 4Fe-4S binding domain; Region: Fer4_6; pfam12837 251229012785 4Fe-4S binding domain; Region: Fer4; pfam00037 251229012786 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 251229012787 TPP-binding site [chemical binding]; other site 251229012788 dimer interface [polypeptide binding]; other site 251229012789 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 251229012790 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 251229012791 putative active site [active] 251229012792 putative FMN binding site [chemical binding]; other site 251229012793 putative substrate binding site [chemical binding]; other site 251229012794 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 251229012795 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 251229012796 active site 251229012797 ADP/pyrophosphate binding site [chemical binding]; other site 251229012798 dimerization interface [polypeptide binding]; other site 251229012799 allosteric effector site; other site 251229012800 fructose-1,6-bisphosphate binding site; other site 251229012801 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 251229012802 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 251229012803 dimerization interface [polypeptide binding]; other site 251229012804 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 251229012805 ATP binding site [chemical binding]; other site 251229012806 Protein of unknown function (DUF456); Region: DUF456; cl01069 251229012807 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 251229012808 Ycf27; Reviewed; Region: orf27; CHL00148 251229012809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229012810 active site 251229012811 phosphorylation site [posttranslational modification] 251229012812 intermolecular recognition site; other site 251229012813 dimerization interface [polypeptide binding]; other site 251229012814 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229012815 DNA binding site [nucleotide binding] 251229012816 DNA repair protein RadA; Provisional; Region: PRK11823 251229012817 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 251229012818 Walker A motif/ATP binding site; other site 251229012819 ATP binding site [chemical binding]; other site 251229012820 Walker B motif; other site 251229012821 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 251229012822 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229012823 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 251229012824 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 251229012825 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 251229012826 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251229012827 NAD binding site [chemical binding]; other site 251229012828 substrate binding site [chemical binding]; other site 251229012829 active site 251229012830 Ycf46; Provisional; Region: ycf46; CHL00195 251229012831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229012832 Walker A motif; other site 251229012833 ATP binding site [chemical binding]; other site 251229012834 Walker B motif; other site 251229012835 arginine finger; other site 251229012836 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 251229012837 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 251229012838 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 251229012839 RNA polymerase factor sigma-70; Validated; Region: PRK08295 251229012840 acetylornithine aminotransferase; Provisional; Region: PRK02627 251229012841 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 251229012842 inhibitor-cofactor binding pocket; inhibition site 251229012843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229012844 catalytic residue [active] 251229012845 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229012846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229012847 S-adenosylmethionine binding site [chemical binding]; other site 251229012848 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229012849 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229012850 active site 251229012851 ATP binding site [chemical binding]; other site 251229012852 substrate binding site [chemical binding]; other site 251229012853 activation loop (A-loop); other site 251229012854 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 251229012855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229012856 S-adenosylmethionine binding site [chemical binding]; other site 251229012857 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 251229012858 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 251229012859 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 251229012860 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 251229012861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229012862 Coenzyme A binding pocket [chemical binding]; other site 251229012863 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 251229012864 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251229012865 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 251229012866 phosphopeptide binding site; other site 251229012867 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229012868 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229012869 structural tetrad; other site 251229012870 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 251229012871 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229012872 active site 251229012873 ATP binding site [chemical binding]; other site 251229012874 substrate binding site [chemical binding]; other site 251229012875 activation loop (A-loop); other site 251229012876 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 251229012877 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251229012878 phosphopeptide binding site; other site 251229012879 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 251229012880 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 251229012881 substrate binding pocket [chemical binding]; other site 251229012882 membrane-bound complex binding site; other site 251229012883 hinge residues; other site 251229012884 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 251229012885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229012886 dimer interface [polypeptide binding]; other site 251229012887 conserved gate region; other site 251229012888 putative PBP binding loops; other site 251229012889 ABC-ATPase subunit interface; other site 251229012890 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 251229012891 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 251229012892 Walker A/P-loop; other site 251229012893 ATP binding site [chemical binding]; other site 251229012894 Q-loop/lid; other site 251229012895 ABC transporter signature motif; other site 251229012896 Walker B; other site 251229012897 D-loop; other site 251229012898 H-loop/switch region; other site 251229012899 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 251229012900 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 251229012901 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 251229012902 Protein export membrane protein; Region: SecD_SecF; cl14618 251229012903 Protein of unknown function, DUF393; Region: DUF393; pfam04134 251229012904 methionine sulfoxide reductase A; Provisional; Region: PRK14054 251229012905 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 251229012906 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 251229012907 putative C-terminal domain interface [polypeptide binding]; other site 251229012908 putative GSH binding site (G-site) [chemical binding]; other site 251229012909 putative dimer interface [polypeptide binding]; other site 251229012910 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 251229012911 putative substrate binding pocket (H-site) [chemical binding]; other site 251229012912 putative N-terminal domain interface [polypeptide binding]; other site 251229012913 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 251229012914 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 251229012915 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 251229012916 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 251229012917 ABC1 family; Region: ABC1; pfam03109 251229012918 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 251229012919 active site 251229012920 ATP binding site [chemical binding]; other site 251229012921 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 251229012922 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 251229012923 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 251229012924 Substrate binding site; other site 251229012925 Transcriptional regulator [Transcription]; Region: LytR; COG1316 251229012926 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 251229012927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229012928 active site 251229012929 phosphorylation site [posttranslational modification] 251229012930 intermolecular recognition site; other site 251229012931 dimerization interface [polypeptide binding]; other site 251229012932 PAS fold; Region: PAS; pfam00989 251229012933 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229012934 putative active site [active] 251229012935 heme pocket [chemical binding]; other site 251229012936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229012937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229012938 dimer interface [polypeptide binding]; other site 251229012939 phosphorylation site [posttranslational modification] 251229012940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229012941 ATP binding site [chemical binding]; other site 251229012942 Mg2+ binding site [ion binding]; other site 251229012943 G-X-G motif; other site 251229012944 Response regulator receiver domain; Region: Response_reg; pfam00072 251229012945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229012946 active site 251229012947 phosphorylation site [posttranslational modification] 251229012948 intermolecular recognition site; other site 251229012949 dimerization interface [polypeptide binding]; other site 251229012950 Cache domain; Region: Cache_1; pfam02743 251229012951 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229012952 HAMP domain; Region: HAMP; pfam00672 251229012953 dimerization interface [polypeptide binding]; other site 251229012954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229012955 dimer interface [polypeptide binding]; other site 251229012956 phosphorylation site [posttranslational modification] 251229012957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229012958 ATP binding site [chemical binding]; other site 251229012959 Mg2+ binding site [ion binding]; other site 251229012960 G-X-G motif; other site 251229012961 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 251229012962 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 251229012963 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 251229012964 dimerization interface [polypeptide binding]; other site 251229012965 active site 251229012966 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251229012967 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229012968 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 251229012969 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 251229012970 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 251229012971 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 251229012972 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 251229012973 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 251229012974 active site 251229012975 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 251229012976 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 251229012977 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 251229012978 inhibitor-cofactor binding pocket; inhibition site 251229012979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229012980 catalytic residue [active] 251229012981 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 251229012982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229012983 catalytic residue [active] 251229012984 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 251229012985 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 251229012986 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 251229012987 active site 251229012988 metal binding site [ion binding]; metal-binding site 251229012989 Protein of unknown function (DUF2396); Region: DUF2396; pfam09654 251229012990 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 251229012991 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 251229012992 trimer interface [polypeptide binding]; other site 251229012993 putative metal binding site [ion binding]; other site 251229012994 Photosystem II protein Y (PsbY); Region: PsbY; pfam06298 251229012995 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251229012996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229012997 binding surface 251229012998 TPR motif; other site 251229012999 TPR repeat; Region: TPR_11; pfam13414 251229013000 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 251229013001 DctM-like transporters; Region: DctM; pfam06808 251229013002 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 251229013003 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 251229013004 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 251229013005 dimer interface [polypeptide binding]; other site 251229013006 decamer (pentamer of dimers) interface [polypeptide binding]; other site 251229013007 catalytic triad [active] 251229013008 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 251229013009 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 251229013010 Ferredoxin [Energy production and conversion]; Region: COG1146 251229013011 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 251229013012 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 251229013013 Walker A/P-loop; other site 251229013014 ATP binding site [chemical binding]; other site 251229013015 Q-loop/lid; other site 251229013016 ABC transporter signature motif; other site 251229013017 Walker B; other site 251229013018 D-loop; other site 251229013019 H-loop/switch region; other site 251229013020 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 251229013021 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 251229013022 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 251229013023 PBP superfamily domain; Region: PBP_like_2; cl17296 251229013024 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 251229013025 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229013026 motif II; other site 251229013027 hydrolase, alpha/beta fold family protein; Region: PLN02824 251229013028 Transcriptional regulator [Transcription]; Region: LytR; COG1316 251229013029 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 251229013030 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 251229013031 Domain of unknown function DUF20; Region: UPF0118; pfam01594 251229013032 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 251229013033 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 251229013034 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 251229013035 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 251229013036 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 251229013037 trimer interface [polypeptide binding]; other site 251229013038 active site 251229013039 substrate binding site [chemical binding]; other site 251229013040 CoA binding site [chemical binding]; other site 251229013041 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 251229013042 active site 251229013043 catalytic residues [active] 251229013044 metal binding site [ion binding]; metal-binding site 251229013045 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251229013046 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 251229013047 phosphopeptide binding site; other site 251229013048 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 251229013049 CHAT domain; Region: CHAT; cl17868 251229013050 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251229013051 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 251229013052 phosphopeptide binding site; other site 251229013053 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 251229013054 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 251229013055 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 251229013056 active site 251229013057 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 251229013058 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 251229013059 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 251229013060 substrate binding site [chemical binding]; other site 251229013061 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866 251229013062 putative hydrophobic ligand binding site [chemical binding]; other site 251229013063 GAF domain; Region: GAF; pfam01590 251229013064 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229013065 GAF domain; Region: GAF; pfam01590 251229013066 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229013067 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229013068 dimer interface [polypeptide binding]; other site 251229013069 phosphorylation site [posttranslational modification] 251229013070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229013071 ATP binding site [chemical binding]; other site 251229013072 Mg2+ binding site [ion binding]; other site 251229013073 G-X-G motif; other site 251229013074 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 251229013075 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 251229013076 active site 251229013077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229013078 Walker A motif; other site 251229013079 ATP binding site [chemical binding]; other site 251229013080 Walker B motif; other site 251229013081 arginine finger; other site 251229013082 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432 251229013083 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 251229013084 Predicted membrane protein [Function unknown]; Region: COG3374 251229013085 Protein of unknown function (DUF981); Region: DUF981; pfam06168 251229013086 methionine sulfoxide reductase B; Provisional; Region: PRK00222 251229013087 SelR domain; Region: SelR; pfam01641 251229013088 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 251229013089 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 251229013090 Walker A/P-loop; other site 251229013091 ATP binding site [chemical binding]; other site 251229013092 Q-loop/lid; other site 251229013093 ABC transporter signature motif; other site 251229013094 Walker B; other site 251229013095 D-loop; other site 251229013096 H-loop/switch region; other site 251229013097 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229013098 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229013099 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 251229013100 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 251229013101 P-loop; other site 251229013102 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 251229013103 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 251229013104 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 251229013105 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 251229013106 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 251229013107 homodimer interface [polypeptide binding]; other site 251229013108 metal binding site [ion binding]; metal-binding site 251229013109 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 251229013110 homodimer interface [polypeptide binding]; other site 251229013111 active site 251229013112 putative chemical substrate binding site [chemical binding]; other site 251229013113 metal binding site [ion binding]; metal-binding site 251229013114 carotene isomerase; Region: carot_isom; TIGR02730 251229013115 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229013116 hydroxyglutarate oxidase; Provisional; Region: PRK11728 251229013117 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 251229013118 active site 251229013119 YGGT family; Region: YGGT; pfam02325 251229013120 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 251229013121 N- and C-terminal domain interface [polypeptide binding]; other site 251229013122 D-xylulose kinase; Region: XylB; TIGR01312 251229013123 active site 251229013124 MgATP binding site [chemical binding]; other site 251229013125 catalytic site [active] 251229013126 metal binding site [ion binding]; metal-binding site 251229013127 xylulose binding site [chemical binding]; other site 251229013128 homodimer interface [polypeptide binding]; other site 251229013129 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 251229013130 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 251229013131 potential catalytic triad [active] 251229013132 conserved cys residue [active] 251229013133 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 251229013134 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 251229013135 PYR/PP interface [polypeptide binding]; other site 251229013136 dimer interface [polypeptide binding]; other site 251229013137 TPP binding site [chemical binding]; other site 251229013138 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 251229013139 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 251229013140 TPP-binding site [chemical binding]; other site 251229013141 dimer interface [polypeptide binding]; other site 251229013142 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 251229013143 EthD domain; Region: EthD; pfam07110 251229013144 EthD domain; Region: EthD; cl17553 251229013145 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 251229013146 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229013147 active site 251229013148 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 251229013149 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 251229013150 SnoaL-like domain; Region: SnoaL_2; pfam12680 251229013151 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 251229013152 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 251229013153 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 251229013154 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 251229013155 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 251229013156 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 251229013157 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 251229013158 intracellular protease, PfpI family; Region: PfpI; TIGR01382 251229013159 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 251229013160 conserved cys residue [active] 251229013161 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 251229013162 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 251229013163 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 251229013164 active site 251229013165 catalytic site [active] 251229013166 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 251229013167 dimerization interface [polypeptide binding]; other site 251229013168 putative active cleft [active] 251229013169 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 251229013170 anti sigma factor interaction site; other site 251229013171 regulatory phosphorylation site [posttranslational modification]; other site 251229013172 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 251229013173 Neurotransmitter-gated ion-channel transmembrane region; Region: Neur_chan_memb; pfam02932 251229013174 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 251229013175 Dynamin family; Region: Dynamin_N; pfam00350 251229013176 G1 box; other site 251229013177 GTP/Mg2+ binding site [chemical binding]; other site 251229013178 G2 box; other site 251229013179 Switch I region; other site 251229013180 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 251229013181 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 251229013182 Domain of unknown function DUF29; Region: DUF29; pfam01724 251229013183 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 251229013184 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 251229013185 RNA binding surface [nucleotide binding]; other site 251229013186 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 251229013187 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 251229013188 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 251229013189 active site 251229013190 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 251229013191 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 251229013192 molybdopterin cofactor binding site; other site 251229013193 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 251229013194 molybdopterin cofactor binding site; other site 251229013195 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 251229013196 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 251229013197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229013198 binding surface 251229013199 TPR motif; other site 251229013200 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 251229013201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229013202 binding surface 251229013203 TPR motif; other site 251229013204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229013205 binding surface 251229013206 TPR motif; other site 251229013207 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 251229013208 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 251229013209 Hexamer interface [polypeptide binding]; other site 251229013210 Hexagonal pore residue; other site 251229013211 Cyclic phosphodiesterase-like protein; Region: CPDase; pfam07823 251229013212 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 251229013213 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 251229013214 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 251229013215 homodimer interface [polypeptide binding]; other site 251229013216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229013217 catalytic residue [active] 251229013218 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 251229013219 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229013220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229013221 active site 251229013222 phosphorylation site [posttranslational modification] 251229013223 intermolecular recognition site; other site 251229013224 dimerization interface [polypeptide binding]; other site 251229013225 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251229013226 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229013227 putative active site [active] 251229013228 heme pocket [chemical binding]; other site 251229013229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229013230 dimer interface [polypeptide binding]; other site 251229013231 phosphorylation site [posttranslational modification] 251229013232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229013233 ATP binding site [chemical binding]; other site 251229013234 Mg2+ binding site [ion binding]; other site 251229013235 G-X-G motif; other site 251229013236 PAS domain S-box; Region: sensory_box; TIGR00229 251229013237 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229013238 putative active site [active] 251229013239 heme pocket [chemical binding]; other site 251229013240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229013241 PAS fold; Region: PAS_3; pfam08447 251229013242 putative active site [active] 251229013243 heme pocket [chemical binding]; other site 251229013244 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 251229013245 Histidine kinase; Region: HisKA_2; pfam07568 251229013246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229013247 ATP binding site [chemical binding]; other site 251229013248 Mg2+ binding site [ion binding]; other site 251229013249 G-X-G motif; other site 251229013250 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 251229013251 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 251229013252 active site 251229013253 catalytic triad [active] 251229013254 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 251229013255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 251229013256 non-specific DNA binding site [nucleotide binding]; other site 251229013257 salt bridge; other site 251229013258 sequence-specific DNA binding site [nucleotide binding]; other site 251229013259 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 251229013260 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 251229013261 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 251229013262 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229013263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229013264 S-adenosylmethionine binding site [chemical binding]; other site 251229013265 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 251229013266 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 251229013267 FeoA domain; Region: FeoA; pfam04023 251229013268 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 251229013269 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251229013270 catalytic loop [active] 251229013271 iron binding site [ion binding]; other site 251229013272 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 251229013273 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 251229013274 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 251229013275 ATP binding site [chemical binding]; other site 251229013276 substrate interface [chemical binding]; other site 251229013277 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102 251229013278 Rop-like; Region: Rop-like; pfam05082 251229013279 Protein of unknown function, DUF269; Region: DUF269; pfam03270 251229013280 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 251229013281 bifunctional nitrogenase molybdenum-cofactor biosynthesis protein NifE/NifN; Provisional; Region: PRK14477 251229013282 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 251229013283 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 251229013284 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 251229013285 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 251229013286 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 251229013287 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 251229013288 MoFe protein beta/alpha subunit interactions; other site 251229013289 Beta subunit P cluster binding residues; other site 251229013290 MoFe protein beta subunit/Fe protein contacts; other site 251229013291 MoFe protein dimer/ dimer interactions; other site 251229013292 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 251229013293 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 251229013294 MoFe protein alpha/beta subunit interactions; other site 251229013295 Alpha subunit P cluster binding residues; other site 251229013296 FeMoco binding residues [chemical binding]; other site 251229013297 MoFe protein alpha subunit/Fe protein contacts; other site 251229013298 MoFe protein dimer/ dimer interactions; other site 251229013299 nitrogenase reductase; Reviewed; Region: PRK13236 251229013300 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 251229013301 Nucleotide-binding sites [chemical binding]; other site 251229013302 Walker A motif; other site 251229013303 Switch I region of nucleotide binding site; other site 251229013304 Fe4S4 binding sites [ion binding]; other site 251229013305 Switch II region of nucleotide binding site; other site 251229013306 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 251229013307 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 251229013308 trimerization site [polypeptide binding]; other site 251229013309 active site 251229013310 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 251229013311 NifU-like domain; Region: NifU; pfam01106 251229013312 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 251229013313 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 251229013314 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 251229013315 catalytic residue [active] 251229013316 4Fe-4S binding domain; Region: Fer4; cl02805 251229013317 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 251229013318 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 251229013319 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251229013320 FeS/SAM binding site; other site 251229013321 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 251229013322 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 251229013323 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 251229013324 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 251229013325 trimer interface [polypeptide binding]; other site 251229013326 active site 251229013327 substrate binding site [chemical binding]; other site 251229013328 CoA binding site [chemical binding]; other site 251229013329 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 251229013330 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 251229013331 dimerization interface [polypeptide binding]; other site 251229013332 DPS ferroxidase diiron center [ion binding]; other site 251229013333 ion pore; other site 251229013334 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 251229013335 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 251229013336 active site 251229013337 catalytic residues [active] 251229013338 metal binding site [ion binding]; metal-binding site 251229013339 NifZ domain; Region: NifZ; pfam04319 251229013340 NifT/FixU protein; Region: NifT; pfam06988 251229013341 OB-fold nucleic acid binding domain; Region: tRNA_anti; pfam01336 251229013342 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 251229013343 dimer interface [polypeptide binding]; other site 251229013344 [2Fe-2S] cluster binding site [ion binding]; other site 251229013345 Protein of unknown function (DUF552); Region: DUF552; pfam04472 251229013346 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 251229013347 NACHT domain; Region: NACHT; pfam05729 251229013348 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 251229013349 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229013350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229013351 S-adenosylmethionine binding site [chemical binding]; other site 251229013352 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 251229013353 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 251229013354 Methyltransferase domain; Region: Methyltransf_24; pfam13578 251229013355 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 251229013356 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 251229013357 Probable Catalytic site; other site 251229013358 metal-binding site 251229013359 hypothetical protein; Provisional; Region: PRK07208 251229013360 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229013361 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 251229013362 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 251229013363 active site 251229013364 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229013365 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229013366 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 251229013367 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 251229013368 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 251229013369 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 251229013370 Walker A/P-loop; other site 251229013371 ATP binding site [chemical binding]; other site 251229013372 Q-loop/lid; other site 251229013373 ABC transporter signature motif; other site 251229013374 Walker B; other site 251229013375 D-loop; other site 251229013376 H-loop/switch region; other site 251229013377 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 251229013378 putative carbohydrate binding site [chemical binding]; other site 251229013379 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229013380 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 251229013381 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229013382 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229013383 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229013384 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229013385 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229013386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229013387 S-adenosylmethionine binding site [chemical binding]; other site 251229013388 Methyltransferase domain; Region: Methyltransf_11; pfam08241 251229013389 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 251229013390 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 251229013391 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 251229013392 Walker A/P-loop; other site 251229013393 ATP binding site [chemical binding]; other site 251229013394 Q-loop/lid; other site 251229013395 ABC transporter signature motif; other site 251229013396 Walker B; other site 251229013397 D-loop; other site 251229013398 H-loop/switch region; other site 251229013399 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 251229013400 putative carbohydrate binding site [chemical binding]; other site 251229013401 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229013402 Methyltransferase domain; Region: Methyltransf_11; pfam08241 251229013403 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 251229013404 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 251229013405 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 251229013406 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229013407 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229013408 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 251229013409 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 251229013410 putative ligand binding site [chemical binding]; other site 251229013411 putative catalytic site [active] 251229013412 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 251229013413 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229013414 active site 251229013415 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 251229013416 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 251229013417 NADP-binding site; other site 251229013418 homotetramer interface [polypeptide binding]; other site 251229013419 substrate binding site [chemical binding]; other site 251229013420 homodimer interface [polypeptide binding]; other site 251229013421 active site 251229013422 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251229013423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229013424 NAD(P) binding site [chemical binding]; other site 251229013425 active site 251229013426 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 251229013427 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 251229013428 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 251229013429 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 251229013430 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 251229013431 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 251229013432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229013433 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 251229013434 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 251229013435 substrate binding site; other site 251229013436 tetramer interface; other site 251229013437 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 251229013438 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 251229013439 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 251229013440 NADP binding site [chemical binding]; other site 251229013441 active site 251229013442 putative substrate binding site [chemical binding]; other site 251229013443 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 251229013444 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 251229013445 Ligand binding site; other site 251229013446 Putative Catalytic site; other site 251229013447 DXD motif; other site 251229013448 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 251229013449 hypothetical protein; Provisional; Region: PRK07233 251229013450 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229013451 amino acid transporter; Region: 2A0306; TIGR00909 251229013452 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 251229013453 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 251229013454 photosystem II reaction center protein Psb28; Region: PS_II_psb28; TIGR03047 251229013455 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 251229013456 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 251229013457 putative NAD(P) binding site [chemical binding]; other site 251229013458 putative active site [active] 251229013459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229013460 putative PBP binding loops; other site 251229013461 ABC-ATPase subunit interface; other site 251229013462 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 251229013463 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 251229013464 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 251229013465 Fasciclin domain; Region: Fasciclin; pfam02469 251229013466 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 251229013467 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 251229013468 active site 251229013469 FMN binding site [chemical binding]; other site 251229013470 substrate binding site [chemical binding]; other site 251229013471 3Fe-4S cluster binding site [ion binding]; other site 251229013472 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 251229013473 domain_subunit interface; other site 251229013474 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 251229013475 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 251229013476 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 251229013477 active site 251229013478 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 251229013479 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 251229013480 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 251229013481 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 251229013482 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 251229013483 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 251229013484 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 251229013485 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 251229013486 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 251229013487 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 251229013488 hydroxyglutarate oxidase; Provisional; Region: PRK11728 251229013489 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 251229013490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 251229013491 non-specific DNA binding site [nucleotide binding]; other site 251229013492 salt bridge; other site 251229013493 sequence-specific DNA binding site [nucleotide binding]; other site 251229013494 Cupin domain; Region: Cupin_2; pfam07883 251229013495 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 251229013496 Clp amino terminal domain; Region: Clp_N; pfam02861 251229013497 Clp amino terminal domain; Region: Clp_N; pfam02861 251229013498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229013499 Walker A motif; other site 251229013500 ATP binding site [chemical binding]; other site 251229013501 Walker B motif; other site 251229013502 arginine finger; other site 251229013503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229013504 Walker A motif; other site 251229013505 ATP binding site [chemical binding]; other site 251229013506 Walker B motif; other site 251229013507 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 251229013508 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 251229013509 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 251229013510 purine monophosphate binding site [chemical binding]; other site 251229013511 dimer interface [polypeptide binding]; other site 251229013512 putative catalytic residues [active] 251229013513 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 251229013514 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 251229013515 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 251229013516 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 251229013517 putative active site [active] 251229013518 substrate binding site [chemical binding]; other site 251229013519 putative cosubstrate binding site; other site 251229013520 catalytic site [active] 251229013521 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 251229013522 substrate binding site [chemical binding]; other site 251229013523 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 251229013524 Bacterial sugar transferase; Region: Bac_transf; pfam02397 251229013525 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229013526 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 251229013527 putative ADP-binding pocket [chemical binding]; other site 251229013528 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229013529 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 251229013530 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 251229013531 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 251229013532 metal-binding site 251229013533 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 251229013534 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229013535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229013536 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 251229013537 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 251229013538 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 251229013539 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 251229013540 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 251229013541 Chain length determinant protein; Region: Wzz; pfam02706 251229013542 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 251229013543 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 251229013544 cytosine permease; Provisional; Region: codB; PRK11017 251229013545 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 251229013546 Na binding site [ion binding]; other site 251229013547 aconitate hydratase; Validated; Region: PRK07229 251229013548 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 251229013549 substrate binding site [chemical binding]; other site 251229013550 ligand binding site [chemical binding]; other site 251229013551 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 251229013552 substrate binding site [chemical binding]; other site 251229013553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229013554 Major Facilitator Superfamily; Region: MFS_1; pfam07690 251229013555 putative substrate translocation pore; other site 251229013556 acylphosphatase; Provisional; Region: PRK14423 251229013557 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 251229013558 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 251229013559 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 251229013560 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251229013561 ATP binding site [chemical binding]; other site 251229013562 putative Mg++ binding site [ion binding]; other site 251229013563 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251229013564 nucleotide binding region [chemical binding]; other site 251229013565 ATP-binding site [chemical binding]; other site 251229013566 DDE superfamily endonuclease; Region: DDE_3; pfam13358 251229013567 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 251229013568 Homeodomain-like domain; Region: HTH_23; pfam13384 251229013569 Winged helix-turn helix; Region: HTH_29; pfam13551 251229013570 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 251229013571 Fasciclin domain; Region: Fasciclin; pfam02469 251229013572 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 251229013573 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 251229013574 ABC-ATPase subunit interface; other site 251229013575 dimer interface [polypeptide binding]; other site 251229013576 putative PBP binding regions; other site 251229013577 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 251229013578 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 251229013579 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 251229013580 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 251229013581 metal binding site [ion binding]; metal-binding site 251229013582 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 251229013583 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 251229013584 alpha-gamma subunit interface [polypeptide binding]; other site 251229013585 beta-gamma subunit interface [polypeptide binding]; other site 251229013586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229013587 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 251229013588 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 251229013589 active site 251229013590 trimer interface [polypeptide binding]; other site 251229013591 allosteric site; other site 251229013592 active site lid [active] 251229013593 hexamer (dimer of trimers) interface [polypeptide binding]; other site 251229013594 Bacterial SH3 domain; Region: SH3_3; pfam08239 251229013595 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 251229013596 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 251229013597 active site 251229013598 metal binding site [ion binding]; metal-binding site 251229013599 CTP synthetase; Validated; Region: pyrG; PRK05380 251229013600 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 251229013601 Catalytic site [active] 251229013602 active site 251229013603 UTP binding site [chemical binding]; other site 251229013604 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 251229013605 active site 251229013606 putative oxyanion hole; other site 251229013607 catalytic triad [active] 251229013608 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 251229013609 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 251229013610 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 251229013611 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 251229013612 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 251229013613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229013614 AAA domain; Region: AAA_23; pfam13476 251229013615 AAA domain; Region: AAA_21; pfam13304 251229013616 Walker A/P-loop; other site 251229013617 ATP binding site [chemical binding]; other site 251229013618 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 251229013619 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 251229013620 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 251229013621 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 251229013622 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 251229013623 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 251229013624 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 251229013625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229013626 S-adenosylmethionine binding site [chemical binding]; other site 251229013627 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 251229013628 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 251229013629 active site 251229013630 (T/H)XGH motif; other site 251229013631 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 251229013632 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 251229013633 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 251229013634 thiamine monophosphate kinase; Provisional; Region: PRK05731 251229013635 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 251229013636 ATP binding site [chemical binding]; other site 251229013637 dimerization interface [polypeptide binding]; other site 251229013638 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 251229013639 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 251229013640 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229013641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229013642 S-adenosylmethionine binding site [chemical binding]; other site 251229013643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 251229013644 glutamine synthetase, type I; Region: GlnA; TIGR00653 251229013645 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 251229013646 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 251229013647 allophycocyanin, beta subunit; Region: apcB; TIGR01337 251229013648 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 251229013649 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 251229013650 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 251229013651 classical (c) SDRs; Region: SDR_c; cd05233 251229013652 NAD(P) binding site [chemical binding]; other site 251229013653 active site 251229013654 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 251229013655 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 251229013656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 251229013657 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 251229013658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229013659 putative PBP binding loops; other site 251229013660 dimer interface [polypeptide binding]; other site 251229013661 ABC-ATPase subunit interface; other site 251229013662 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 251229013663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229013664 dimer interface [polypeptide binding]; other site 251229013665 conserved gate region; other site 251229013666 putative PBP binding loops; other site 251229013667 ABC-ATPase subunit interface; other site 251229013668 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 251229013669 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 251229013670 Walker A/P-loop; other site 251229013671 ATP binding site [chemical binding]; other site 251229013672 Q-loop/lid; other site 251229013673 ABC transporter signature motif; other site 251229013674 Walker B; other site 251229013675 D-loop; other site 251229013676 H-loop/switch region; other site 251229013677 TOBE domain; Region: TOBE_2; pfam08402 251229013678 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 251229013679 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 251229013680 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 251229013681 Fatty acid desaturase; Region: FA_desaturase; pfam00487 251229013682 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 251229013683 putative di-iron ligands [ion binding]; other site 251229013684 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 251229013685 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 251229013686 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 251229013687 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 251229013688 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 251229013689 Walker A/P-loop; other site 251229013690 ATP binding site [chemical binding]; other site 251229013691 Q-loop/lid; other site 251229013692 ABC transporter signature motif; other site 251229013693 Walker B; other site 251229013694 D-loop; other site 251229013695 H-loop/switch region; other site 251229013696 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 251229013697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229013698 dimer interface [polypeptide binding]; other site 251229013699 conserved gate region; other site 251229013700 putative PBP binding loops; other site 251229013701 ABC-ATPase subunit interface; other site 251229013702 Isochorismatase family; Region: Isochorismatase; pfam00857 251229013703 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 251229013704 catalytic triad [active] 251229013705 conserved cis-peptide bond; other site 251229013706 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 251229013707 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 251229013708 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 251229013709 NADH(P)-binding; Region: NAD_binding_10; pfam13460 251229013710 NAD(P) binding site [chemical binding]; other site 251229013711 putative active site [active] 251229013712 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 251229013713 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 251229013714 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 251229013715 protein binding site [polypeptide binding]; other site 251229013716 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 251229013717 Domain interface; other site 251229013718 Peptide binding site; other site 251229013719 Active site tetrad [active] 251229013720 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 251229013721 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 251229013722 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 251229013723 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 251229013724 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229013725 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229013726 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 251229013727 active site 251229013728 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 251229013729 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 251229013730 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 251229013731 PsaD; Region: PsaD; cl03639 251229013732 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 251229013733 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229013734 GAF domain; Region: GAF; pfam01590 251229013735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229013736 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229013737 dimer interface [polypeptide binding]; other site 251229013738 phosphorylation site [posttranslational modification] 251229013739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229013740 ATP binding site [chemical binding]; other site 251229013741 Mg2+ binding site [ion binding]; other site 251229013742 G-X-G motif; other site 251229013743 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 251229013744 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229013745 putative ADP-binding pocket [chemical binding]; other site 251229013746 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 251229013747 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 251229013748 PetN; Region: PetN; pfam03742 251229013749 PhoD-like phosphatase; Region: PhoD; pfam09423 251229013750 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 251229013751 putative active site [active] 251229013752 putative metal binding site [ion binding]; other site 251229013753 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 251229013754 Response regulator receiver domain; Region: Response_reg; pfam00072 251229013755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229013756 active site 251229013757 phosphorylation site [posttranslational modification] 251229013758 intermolecular recognition site; other site 251229013759 dimerization interface [polypeptide binding]; other site 251229013760 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 251229013761 putative binding surface; other site 251229013762 active site 251229013763 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 251229013764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229013765 ATP binding site [chemical binding]; other site 251229013766 Mg2+ binding site [ion binding]; other site 251229013767 G-X-G motif; other site 251229013768 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 251229013769 Response regulator receiver domain; Region: Response_reg; pfam00072 251229013770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229013771 active site 251229013772 phosphorylation site [posttranslational modification] 251229013773 intermolecular recognition site; other site 251229013774 dimerization interface [polypeptide binding]; other site 251229013775 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229013776 dimerization interface [polypeptide binding]; other site 251229013777 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 251229013778 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 251229013779 dimer interface [polypeptide binding]; other site 251229013780 putative CheW interface [polypeptide binding]; other site 251229013781 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 251229013782 Response regulator receiver domain; Region: Response_reg; pfam00072 251229013783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229013784 active site 251229013785 phosphorylation site [posttranslational modification] 251229013786 intermolecular recognition site; other site 251229013787 dimerization interface [polypeptide binding]; other site 251229013788 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 251229013789 dimerization interface [polypeptide binding]; other site 251229013790 putative active cleft [active] 251229013791 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 251229013792 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 251229013793 putative NAD(P) binding site [chemical binding]; other site 251229013794 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 251229013795 cell division protein; Validated; Region: ftsH; CHL00176 251229013796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229013797 Walker A motif; other site 251229013798 ATP binding site [chemical binding]; other site 251229013799 Walker B motif; other site 251229013800 arginine finger; other site 251229013801 Peptidase family M41; Region: Peptidase_M41; pfam01434 251229013802 Predicted flavoprotein [General function prediction only]; Region: COG0431 251229013803 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 251229013804 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 251229013805 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 251229013806 C-terminal domain interface [polypeptide binding]; other site 251229013807 active site 251229013808 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 251229013809 active site 251229013810 N-terminal domain interface [polypeptide binding]; other site 251229013811 GAF domain; Region: GAF; pfam01590 251229013812 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229013813 CHASE3 domain; Region: CHASE3; pfam05227 251229013814 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229013815 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 251229013816 putative active site [active] 251229013817 heme pocket [chemical binding]; other site 251229013818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229013819 putative active site [active] 251229013820 heme pocket [chemical binding]; other site 251229013821 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229013822 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229013823 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229013824 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229013825 metal binding site [ion binding]; metal-binding site 251229013826 active site 251229013827 I-site; other site 251229013828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229013829 H+ Antiporter protein; Region: 2A0121; TIGR00900 251229013830 putative substrate translocation pore; other site 251229013831 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 251229013832 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 251229013833 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 251229013834 PYR/PP interface [polypeptide binding]; other site 251229013835 dimer interface [polypeptide binding]; other site 251229013836 TPP binding site [chemical binding]; other site 251229013837 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 251229013838 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 251229013839 TPP-binding site [chemical binding]; other site 251229013840 dimer interface [polypeptide binding]; other site 251229013841 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 251229013842 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 251229013843 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 251229013844 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 251229013845 Walker A/P-loop; other site 251229013846 ATP binding site [chemical binding]; other site 251229013847 Q-loop/lid; other site 251229013848 ABC transporter signature motif; other site 251229013849 Walker B; other site 251229013850 D-loop; other site 251229013851 H-loop/switch region; other site 251229013852 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 251229013853 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 251229013854 elongation factor Tu; Region: tufA; CHL00071 251229013855 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 251229013856 G1 box; other site 251229013857 GEF interaction site [polypeptide binding]; other site 251229013858 GTP/Mg2+ binding site [chemical binding]; other site 251229013859 Switch I region; other site 251229013860 G2 box; other site 251229013861 G3 box; other site 251229013862 Switch II region; other site 251229013863 G4 box; other site 251229013864 G5 box; other site 251229013865 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 251229013866 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 251229013867 Antibiotic Binding Site [chemical binding]; other site 251229013868 elongation factor G; Reviewed; Region: PRK00007 251229013869 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 251229013870 G1 box; other site 251229013871 putative GEF interaction site [polypeptide binding]; other site 251229013872 GTP/Mg2+ binding site [chemical binding]; other site 251229013873 Switch I region; other site 251229013874 G2 box; other site 251229013875 G3 box; other site 251229013876 Switch II region; other site 251229013877 G4 box; other site 251229013878 G5 box; other site 251229013879 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 251229013880 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 251229013881 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 251229013882 30S ribosomal protein S7; Validated; Region: PRK05302 251229013883 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 251229013884 S17 interaction site [polypeptide binding]; other site 251229013885 S8 interaction site; other site 251229013886 16S rRNA interaction site [nucleotide binding]; other site 251229013887 streptomycin interaction site [chemical binding]; other site 251229013888 23S rRNA interaction site [nucleotide binding]; other site 251229013889 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 251229013890 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 251229013891 Cupin domain; Region: Cupin_2; cl17218 251229013892 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 251229013893 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229013894 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229013895 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229013896 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229013897 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229013898 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229013899 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 251229013900 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 251229013901 Chain length determinant protein; Region: Wzz; pfam02706 251229013902 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 251229013903 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229013904 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 251229013905 putative acyl transferase; Provisional; Region: PRK10502 251229013906 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 251229013907 putative trimer interface [polypeptide binding]; other site 251229013908 putative active site [active] 251229013909 putative substrate binding site [chemical binding]; other site 251229013910 putative CoA binding site [chemical binding]; other site 251229013911 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 251229013912 putative active site [active] 251229013913 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229013914 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 251229013915 putative ADP-binding pocket [chemical binding]; other site 251229013916 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229013917 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 251229013918 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229013919 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229013920 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229013921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229013922 S-adenosylmethionine binding site [chemical binding]; other site 251229013923 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 251229013924 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 251229013925 active site 251229013926 Methyltransferase domain; Region: Methyltransf_11; pfam08241 251229013927 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229013928 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229013929 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229013930 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229013931 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 251229013932 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 251229013933 NAD binding site [chemical binding]; other site 251229013934 homotetramer interface [polypeptide binding]; other site 251229013935 homodimer interface [polypeptide binding]; other site 251229013936 active site 251229013937 substrate binding site [chemical binding]; other site 251229013938 Bacterial Ig-like domain; Region: Big_5; pfam13205 251229013939 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 251229013940 Bacterial Ig-like domain; Region: Big_5; pfam13205 251229013941 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 251229013942 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 251229013943 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 251229013944 Bacterial Ig-like domain; Region: Big_5; pfam13205 251229013945 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 251229013946 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 251229013947 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229013948 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229013949 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229013950 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229013951 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 251229013952 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 251229013953 inhibitor-cofactor binding pocket; inhibition site 251229013954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229013955 catalytic residue [active] 251229013956 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 251229013957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229013958 NAD(P) binding site [chemical binding]; other site 251229013959 active site 251229013960 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229013961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229013962 S-adenosylmethionine binding site [chemical binding]; other site 251229013963 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 251229013964 trimer interface [polypeptide binding]; other site 251229013965 active site 251229013966 substrate binding site [chemical binding]; other site 251229013967 CoA binding site [chemical binding]; other site 251229013968 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 251229013969 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 251229013970 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 251229013971 iron-sulfur cluster [ion binding]; other site 251229013972 [2Fe-2S] cluster binding site [ion binding]; other site 251229013973 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 251229013974 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 251229013975 inhibitor-cofactor binding pocket; inhibition site 251229013976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229013977 catalytic residue [active] 251229013978 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 251229013979 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 251229013980 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 251229013981 putative trimer interface [polypeptide binding]; other site 251229013982 putative active site [active] 251229013983 putative substrate binding site [chemical binding]; other site 251229013984 putative CoA binding site [chemical binding]; other site 251229013985 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 251229013986 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 251229013987 Walker A/P-loop; other site 251229013988 ATP binding site [chemical binding]; other site 251229013989 Q-loop/lid; other site 251229013990 ABC transporter signature motif; other site 251229013991 Walker B; other site 251229013992 D-loop; other site 251229013993 H-loop/switch region; other site 251229013994 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 251229013995 putative carbohydrate binding site [chemical binding]; other site 251229013996 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 251229013997 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 251229013998 S-layer homology domain; Region: SLH; pfam00395 251229013999 S-layer homology domain; Region: SLH; pfam00395 251229014000 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229014001 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 251229014002 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 251229014003 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 251229014004 inhibitor-cofactor binding pocket; inhibition site 251229014005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229014006 catalytic residue [active] 251229014007 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 251229014008 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 251229014009 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 251229014010 putative acyl-acceptor binding pocket; other site 251229014011 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 251229014012 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 251229014013 HIGH motif; other site 251229014014 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 251229014015 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 251229014016 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 251229014017 active site 251229014018 KMSKS motif; other site 251229014019 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 251229014020 tRNA binding surface [nucleotide binding]; other site 251229014021 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 251229014022 putative active site pocket [active] 251229014023 dimerization interface [polypeptide binding]; other site 251229014024 putative catalytic residue [active] 251229014025 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 251229014026 Putative zinc-finger; Region: zf-HC2; pfam13490 251229014027 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 251229014028 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251229014029 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251229014030 DNA binding residues [nucleotide binding] 251229014031 Late competence development protein ComFB; Region: ComFB; pfam10719 251229014032 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 251229014033 Peptidase family M23; Region: Peptidase_M23; pfam01551 251229014034 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 251229014035 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 251229014036 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 251229014037 TrkA-N domain; Region: TrkA_N; pfam02254 251229014038 TrkA-C domain; Region: TrkA_C; pfam02080 251229014039 TrkA-C domain; Region: TrkA_C; pfam02080 251229014040 Sm and related proteins; Region: Sm_like; cl00259 251229014041 heptamer interface [polypeptide binding]; other site 251229014042 Sm1 motif; other site 251229014043 hexamer interface [polypeptide binding]; other site 251229014044 RNA binding site [nucleotide binding]; other site 251229014045 Sm2 motif; other site 251229014046 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 251229014047 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 251229014048 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 251229014049 Transcriptional regulators [Transcription]; Region: MarR; COG1846 251229014050 MarR family; Region: MarR_2; pfam12802 251229014051 Transcriptional regulator PadR-like family; Region: PadR; cl17335 251229014052 AAA ATPase domain; Region: AAA_16; pfam13191 251229014053 NB-ARC domain; Region: NB-ARC; pfam00931 251229014054 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 251229014055 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229014056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229014057 active site 251229014058 phosphorylation site [posttranslational modification] 251229014059 intermolecular recognition site; other site 251229014060 dimerization interface [polypeptide binding]; other site 251229014061 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229014062 PAS domain; Region: PAS_9; pfam13426 251229014063 putative active site [active] 251229014064 heme pocket [chemical binding]; other site 251229014065 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229014066 GAF domain; Region: GAF; pfam01590 251229014067 PAS domain S-box; Region: sensory_box; TIGR00229 251229014068 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229014069 putative active site [active] 251229014070 heme pocket [chemical binding]; other site 251229014071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229014072 dimer interface [polypeptide binding]; other site 251229014073 phosphorylation site [posttranslational modification] 251229014074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229014075 ATP binding site [chemical binding]; other site 251229014076 Mg2+ binding site [ion binding]; other site 251229014077 G-X-G motif; other site 251229014078 Response regulator receiver domain; Region: Response_reg; pfam00072 251229014079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229014080 active site 251229014081 phosphorylation site [posttranslational modification] 251229014082 intermolecular recognition site; other site 251229014083 dimerization interface [polypeptide binding]; other site 251229014084 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 251229014085 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 251229014086 cobalamin binding residues [chemical binding]; other site 251229014087 putative BtuC binding residues; other site 251229014088 dimer interface [polypeptide binding]; other site 251229014089 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 251229014090 PHP domain; Region: PHP; pfam02811 251229014091 active site 251229014092 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 251229014093 hypothetical protein; Provisional; Region: PRK04194 251229014094 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251229014095 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 251229014096 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 251229014097 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 251229014098 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 251229014099 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 251229014100 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 251229014101 substrate binding site [chemical binding]; other site 251229014102 active site 251229014103 catalytic residues [active] 251229014104 heterodimer interface [polypeptide binding]; other site 251229014105 thymidylate kinase; Validated; Region: tmk; PRK00698 251229014106 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 251229014107 TMP-binding site; other site 251229014108 ATP-binding site [chemical binding]; other site 251229014109 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 251229014110 DNA polymerase III subunit delta'; Validated; Region: PRK07399 251229014111 DNA polymerase III subunit delta'; Validated; Region: PRK08485 251229014112 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 251229014113 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 251229014114 quinone interaction residues [chemical binding]; other site 251229014115 active site 251229014116 catalytic residues [active] 251229014117 FMN binding site [chemical binding]; other site 251229014118 substrate binding site [chemical binding]; other site 251229014119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229014120 S-adenosylmethionine binding site [chemical binding]; other site 251229014121 heat shock protein HtpX; Provisional; Region: PRK03982 251229014122 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 251229014123 E-class dimer interface [polypeptide binding]; other site 251229014124 P-class dimer interface [polypeptide binding]; other site 251229014125 active site 251229014126 Cu2+ binding site [ion binding]; other site 251229014127 Zn2+ binding site [ion binding]; other site 251229014128 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 251229014129 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 251229014130 TM-ABC transporter signature motif; other site 251229014131 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 251229014132 active site 251229014133 Helix-turn-helix domain; Region: HTH_28; pfam13518 251229014134 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 251229014135 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 251229014136 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 251229014137 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 251229014138 protein binding site [polypeptide binding]; other site 251229014139 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 251229014140 nitrilase; Region: PLN02798 251229014141 putative active site [active] 251229014142 catalytic triad [active] 251229014143 dimer interface [polypeptide binding]; other site 251229014144 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 251229014145 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 251229014146 intersubunit interface [polypeptide binding]; other site 251229014147 active site 251229014148 zinc binding site [ion binding]; other site 251229014149 Na+ binding site [ion binding]; other site 251229014150 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229014151 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 251229014152 Coenzyme A binding pocket [chemical binding]; other site 251229014153 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 251229014154 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 251229014155 aromatic acid decarboxylase; Validated; Region: PRK05920 251229014156 Flavoprotein; Region: Flavoprotein; pfam02441 251229014157 Exoribonuclease R [Transcription]; Region: VacB; COG0557 251229014158 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 251229014159 RNB domain; Region: RNB; pfam00773 251229014160 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 251229014161 RNA binding site [nucleotide binding]; other site 251229014162 Clp protease; Region: CLP_protease; pfam00574 251229014163 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 251229014164 oligomer interface [polypeptide binding]; other site 251229014165 active site residues [active] 251229014166 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 251229014167 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 251229014168 catalytic residues [active] 251229014169 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 251229014170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229014171 Walker A motif; other site 251229014172 ATP binding site [chemical binding]; other site 251229014173 Walker B motif; other site 251229014174 arginine finger; other site 251229014175 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 251229014176 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 251229014177 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 251229014178 DXD motif; other site 251229014179 CbiD; Region: CbiD; cl00828 251229014180 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 251229014181 GMP synthase; Reviewed; Region: guaA; PRK00074 251229014182 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 251229014183 AMP/PPi binding site [chemical binding]; other site 251229014184 candidate oxyanion hole; other site 251229014185 catalytic triad [active] 251229014186 potential glutamine specificity residues [chemical binding]; other site 251229014187 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 251229014188 ATP Binding subdomain [chemical binding]; other site 251229014189 Ligand Binding sites [chemical binding]; other site 251229014190 Dimerization subdomain; other site 251229014191 Predicted transcriptional regulators [Transcription]; Region: COG1733 251229014192 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 251229014193 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 251229014194 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 251229014195 putative NAD(P) binding site [chemical binding]; other site 251229014196 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 251229014197 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 251229014198 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 251229014199 active site 251229014200 SAM binding site [chemical binding]; other site 251229014201 homodimer interface [polypeptide binding]; other site 251229014202 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 251229014203 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 251229014204 multifunctional aminopeptidase A; Provisional; Region: PRK00913 251229014205 interface (dimer of trimers) [polypeptide binding]; other site 251229014206 Substrate-binding/catalytic site; other site 251229014207 Zn-binding sites [ion binding]; other site 251229014208 shikimate kinase; Reviewed; Region: aroK; PRK00131 251229014209 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 251229014210 ADP binding site [chemical binding]; other site 251229014211 magnesium binding site [ion binding]; other site 251229014212 putative shikimate binding site; other site 251229014213 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 251229014214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229014215 TPR motif; other site 251229014216 binding surface 251229014217 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229014218 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229014219 active site 251229014220 ATP binding site [chemical binding]; other site 251229014221 substrate binding site [chemical binding]; other site 251229014222 activation loop (A-loop); other site 251229014223 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251229014224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229014225 active site 251229014226 phosphorylation site [posttranslational modification] 251229014227 intermolecular recognition site; other site 251229014228 dimerization interface [polypeptide binding]; other site 251229014229 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251229014230 DNA binding residues [nucleotide binding] 251229014231 dimerization interface [polypeptide binding]; other site 251229014232 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 251229014233 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 251229014234 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229014235 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 251229014236 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 251229014237 putative active site [active] 251229014238 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229014239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229014240 Walker A/P-loop; other site 251229014241 ATP binding site [chemical binding]; other site 251229014242 Q-loop/lid; other site 251229014243 ABC transporter signature motif; other site 251229014244 Walker B; other site 251229014245 D-loop; other site 251229014246 H-loop/switch region; other site 251229014247 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 251229014248 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 251229014249 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 251229014250 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251229014251 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251229014252 ligand binding site [chemical binding]; other site 251229014253 flexible hinge region; other site 251229014254 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 251229014255 putative switch regulator; other site 251229014256 non-specific DNA interactions [nucleotide binding]; other site 251229014257 DNA binding site [nucleotide binding] 251229014258 sequence specific DNA binding site [nucleotide binding]; other site 251229014259 putative cAMP binding site [chemical binding]; other site 251229014260 Response regulator receiver domain; Region: Response_reg; pfam00072 251229014261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229014262 active site 251229014263 phosphorylation site [posttranslational modification] 251229014264 intermolecular recognition site; other site 251229014265 dimerization interface [polypeptide binding]; other site 251229014266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229014267 dimer interface [polypeptide binding]; other site 251229014268 phosphorylation site [posttranslational modification] 251229014269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229014270 Mg2+ binding site [ion binding]; other site 251229014271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229014272 ATP binding site [chemical binding]; other site 251229014273 G-X-G motif; other site 251229014274 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229014275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229014276 active site 251229014277 phosphorylation site [posttranslational modification] 251229014278 intermolecular recognition site; other site 251229014279 dimerization interface [polypeptide binding]; other site 251229014280 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 251229014281 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229014282 dimerization interface [polypeptide binding]; other site 251229014283 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229014284 dimerization interface [polypeptide binding]; other site 251229014285 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229014286 dimerization interface [polypeptide binding]; other site 251229014287 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229014288 dimerization interface [polypeptide binding]; other site 251229014289 GAF domain; Region: GAF_2; pfam13185 251229014290 GAF domain; Region: GAF; cl17456 251229014291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229014292 dimer interface [polypeptide binding]; other site 251229014293 phosphorylation site [posttranslational modification] 251229014294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229014295 ATP binding site [chemical binding]; other site 251229014296 Mg2+ binding site [ion binding]; other site 251229014297 G-X-G motif; other site 251229014298 Response regulator receiver domain; Region: Response_reg; pfam00072 251229014299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229014300 active site 251229014301 phosphorylation site [posttranslational modification] 251229014302 intermolecular recognition site; other site 251229014303 dimerization interface [polypeptide binding]; other site 251229014304 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229014305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229014306 active site 251229014307 phosphorylation site [posttranslational modification] 251229014308 intermolecular recognition site; other site 251229014309 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229014310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229014311 active site 251229014312 phosphorylation site [posttranslational modification] 251229014313 intermolecular recognition site; other site 251229014314 dimerization interface [polypeptide binding]; other site 251229014315 HAS barrel domain; Region: HAS-barrel; pfam09378 251229014316 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251229014317 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251229014318 ligand binding site [chemical binding]; other site 251229014319 flexible hinge region; other site 251229014320 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 251229014321 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 251229014322 CheB methylesterase; Region: CheB_methylest; pfam01339 251229014323 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 251229014324 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 251229014325 Domain of unknown function DUF59; Region: DUF59; pfam01883 251229014326 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 251229014327 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 251229014328 Walker A motif; other site 251229014329 Uncharacterized conserved protein [Function unknown]; Region: COG1434 251229014330 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 251229014331 putative active site [active] 251229014332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 251229014333 Predicted kinase [General function prediction only]; Region: COG0645 251229014334 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 251229014335 ATP-binding site [chemical binding]; other site 251229014336 Gluconate-6-phosphate binding site [chemical binding]; other site 251229014337 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 251229014338 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 251229014339 5S rRNA interface [nucleotide binding]; other site 251229014340 CTC domain interface [polypeptide binding]; other site 251229014341 L16 interface [polypeptide binding]; other site 251229014342 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 251229014343 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 251229014344 GDP-binding site [chemical binding]; other site 251229014345 ACT binding site; other site 251229014346 IMP binding site; other site 251229014347 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 251229014348 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 251229014349 hinge; other site 251229014350 active site 251229014351 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 251229014352 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 251229014353 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 251229014354 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 251229014355 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 251229014356 23S rRNA binding site [nucleotide binding]; other site 251229014357 L21 binding site [polypeptide binding]; other site 251229014358 L13 binding site [polypeptide binding]; other site 251229014359 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 251229014360 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 251229014361 substrate binding pocket [chemical binding]; other site 251229014362 membrane-bound complex binding site; other site 251229014363 hinge residues; other site 251229014364 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 251229014365 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 251229014366 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 251229014367 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 251229014368 Competence protein; Region: Competence; pfam03772 251229014369 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 251229014370 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 251229014371 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 251229014372 dimer interface [polypeptide binding]; other site 251229014373 motif 1; other site 251229014374 active site 251229014375 motif 2; other site 251229014376 motif 3; other site 251229014377 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 251229014378 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 251229014379 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 251229014380 active site 251229014381 putative substrate binding pocket [chemical binding]; other site 251229014382 Isochorismatase family; Region: Isochorismatase; pfam00857 251229014383 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 251229014384 catalytic triad [active] 251229014385 conserved cis-peptide bond; other site 251229014386 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 251229014387 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 251229014388 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 251229014389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 251229014390 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 251229014391 DNA-binding site [nucleotide binding]; DNA binding site 251229014392 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 251229014393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229014394 homodimer interface [polypeptide binding]; other site 251229014395 catalytic residue [active] 251229014396 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229014397 Coenzyme A binding pocket [chemical binding]; other site 251229014398 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 251229014399 active site 251229014400 hydrophilic channel; other site 251229014401 dimerization interface [polypeptide binding]; other site 251229014402 catalytic residues [active] 251229014403 active site lid [active] 251229014404 Protein of unknown function (DUF2419); Region: DUF2419; pfam10343 251229014405 Protein of unknown function (DUF952); Region: DUF952; cl01393 251229014406 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 251229014407 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 251229014408 catalytic residues [active] 251229014409 Predicted membrane protein [Function unknown]; Region: COG4270 251229014410 SnoaL-like domain; Region: SnoaL_2; pfam12680 251229014411 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 251229014412 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 251229014413 putative dimer interface [polypeptide binding]; other site 251229014414 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 251229014415 feedback inhibition sensing region; other site 251229014416 homohexameric interface [polypeptide binding]; other site 251229014417 nucleotide binding site [chemical binding]; other site 251229014418 N-acetyl-L-glutamate binding site [chemical binding]; other site 251229014419 Tetratricopeptide repeat; Region: TPR_16; pfam13432 251229014420 FRG domain; Region: FRG; pfam08867 251229014421 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 251229014422 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 251229014423 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 251229014424 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 251229014425 Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596 251229014426 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 251229014427 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 251229014428 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 251229014429 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 251229014430 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 251229014431 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 251229014432 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 251229014433 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 251229014434 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 251229014435 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 251229014436 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 251229014437 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 251229014438 active site 251229014439 putative homodimer interface [polypeptide binding]; other site 251229014440 SAM binding site [chemical binding]; other site 251229014441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 251229014442 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 251229014443 precorrin-8X methylmutase; Provisional; Region: PRK05954 251229014444 Precorrin-8X methylmutase; Region: CbiC; pfam02570 251229014445 DNA polymerase III subunit delta; Validated; Region: PRK07452 251229014446 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 251229014447 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 251229014448 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 251229014449 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 251229014450 dimer interface [polypeptide binding]; other site 251229014451 catalytic residues [active] 251229014452 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 251229014453 UreF; Region: UreF; pfam01730 251229014454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229014455 S-adenosylmethionine binding site [chemical binding]; other site 251229014456 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 251229014457 Rrf2 family protein; Region: rrf2_super; TIGR00738 251229014458 Transcriptional regulator; Region: Rrf2; pfam02082 251229014459 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 251229014460 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 251229014461 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 251229014462 Cl- selectivity filter; other site 251229014463 Cl- binding residues [ion binding]; other site 251229014464 pore gating glutamate residue; other site 251229014465 dimer interface [polypeptide binding]; other site 251229014466 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593 251229014467 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 251229014468 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 251229014469 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 251229014470 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 251229014471 iron-sulfur cluster [ion binding]; other site 251229014472 [2Fe-2S] cluster binding site [ion binding]; other site 251229014473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251229014474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 251229014475 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 251229014476 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251229014477 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 251229014478 ligand binding site [chemical binding]; other site 251229014479 flexible hinge region; other site 251229014480 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229014481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229014482 ATP binding site [chemical binding]; other site 251229014483 Mg2+ binding site [ion binding]; other site 251229014484 G-X-G motif; other site 251229014485 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 251229014486 active site 251229014487 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 251229014488 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 251229014489 active site 251229014490 purine riboside binding site [chemical binding]; other site 251229014491 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 251229014492 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 251229014493 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 251229014494 Walker A/P-loop; other site 251229014495 ATP binding site [chemical binding]; other site 251229014496 Q-loop/lid; other site 251229014497 ABC transporter signature motif; other site 251229014498 Walker B; other site 251229014499 D-loop; other site 251229014500 H-loop/switch region; other site 251229014501 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 251229014502 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 251229014503 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 251229014504 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 251229014505 TM-ABC transporter signature motif; other site 251229014506 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 251229014507 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 251229014508 active site 251229014509 dimer interface [polypeptide binding]; other site 251229014510 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 251229014511 dimer interface [polypeptide binding]; other site 251229014512 active site 251229014513 Cupin domain; Region: Cupin_2; cl17218 251229014514 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251229014515 Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229 251229014516 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 251229014517 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 251229014518 active site 251229014519 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 251229014520 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 251229014521 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 251229014522 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 251229014523 Moco binding site; other site 251229014524 metal coordination site [ion binding]; other site 251229014525 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 251229014526 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 251229014527 Protein of unknown function, DUF608; Region: DUF608; pfam04685 251229014528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229014529 Major Facilitator Superfamily; Region: MFS_1; pfam07690 251229014530 putative substrate translocation pore; other site 251229014531 SET domain; Region: SET; pfam00856 251229014532 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 251229014533 active site clefts [active] 251229014534 zinc binding site [ion binding]; other site 251229014535 dimer interface [polypeptide binding]; other site 251229014536 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 251229014537 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 251229014538 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 251229014539 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 251229014540 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 251229014541 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 251229014542 5-oxoprolinase; Region: PLN02666 251229014543 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 251229014544 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 251229014545 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 251229014546 M28 Zn-Peptidases; Region: M28_like_1; cd05640 251229014547 Peptidase family M28; Region: Peptidase_M28; pfam04389 251229014548 metal binding site [ion binding]; metal-binding site 251229014549 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 251229014550 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cd00590 251229014551 Predicted integral membrane protein [Function unknown]; Region: COG0392 251229014552 Rhomboid family; Region: Rhomboid; pfam01694 251229014553 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 251229014554 photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056 251229014555 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 251229014556 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 251229014557 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 251229014558 Recombinase; Region: Recombinase; pfam07508 251229014559 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 251229014560 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 251229014561 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 251229014562 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229014563 dimer interface [polypeptide binding]; other site 251229014564 putative metal binding site [ion binding]; other site 251229014565 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229014566 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229014567 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229014568 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229014569 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 251229014570 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 251229014571 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 251229014572 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 251229014573 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 251229014574 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 251229014575 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 251229014576 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 251229014577 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 251229014578 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 251229014579 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 251229014580 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 251229014581 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 251229014582 NADH(P)-binding; Region: NAD_binding_10; pfam13460 251229014583 NAD(P) binding site [chemical binding]; other site 251229014584 putative active site [active] 251229014585 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 251229014586 N-acetyl-D-glucosamine binding site [chemical binding]; other site 251229014587 catalytic residue [active] 251229014588 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 251229014589 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 251229014590 putative homodimer interface [polypeptide binding]; other site 251229014591 putative active site pocket [active] 251229014592 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 251229014593 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 251229014594 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229014595 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229014596 active site 251229014597 ATP binding site [chemical binding]; other site 251229014598 substrate binding site [chemical binding]; other site 251229014599 activation loop (A-loop); other site 251229014600 FecR protein; Region: FecR; pfam04773 251229014601 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 251229014602 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 251229014603 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251229014604 DNA binding residues [nucleotide binding] 251229014605 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 251229014606 EVE domain; Region: EVE; cl00728 251229014607 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 251229014608 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 251229014609 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 251229014610 NAD binding site [chemical binding]; other site 251229014611 ligand binding site [chemical binding]; other site 251229014612 catalytic site [active] 251229014613 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 251229014614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229014615 dimer interface [polypeptide binding]; other site 251229014616 conserved gate region; other site 251229014617 putative PBP binding loops; other site 251229014618 ABC-ATPase subunit interface; other site 251229014619 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 251229014620 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 251229014621 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 251229014622 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 251229014623 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 251229014624 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 251229014625 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 251229014626 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 251229014627 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 251229014628 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 251229014629 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 251229014630 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229014631 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229014632 structural tetrad; other site 251229014633 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229014634 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229014635 active site 251229014636 ATP binding site [chemical binding]; other site 251229014637 substrate binding site [chemical binding]; other site 251229014638 activation loop (A-loop); other site 251229014639 Haemolytic domain; Region: Haemolytic; pfam01809 251229014640 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 251229014641 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 251229014642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 251229014643 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 251229014644 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 251229014645 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 251229014646 non-specific DNA binding site [nucleotide binding]; other site 251229014647 salt bridge; other site 251229014648 sequence-specific DNA binding site [nucleotide binding]; other site 251229014649 Cupin domain; Region: Cupin_2; pfam07883 251229014650 adenosine deaminase; Provisional; Region: PRK09358 251229014651 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 251229014652 active site 251229014653 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 251229014654 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 251229014655 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 251229014656 classical (c) SDRs; Region: SDR_c; cd05233 251229014657 NAD(P) binding site [chemical binding]; other site 251229014658 active site 251229014659 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251229014660 phosphopeptide binding site; other site 251229014661 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 251229014662 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 251229014663 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 251229014664 NAD(P) binding site [chemical binding]; other site 251229014665 homodimer interface [polypeptide binding]; other site 251229014666 substrate binding site [chemical binding]; other site 251229014667 active site 251229014668 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 251229014669 ribonuclease Z; Region: RNase_Z; TIGR02651 251229014670 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 251229014671 homotrimer interface [polypeptide binding]; other site 251229014672 Walker A motif; other site 251229014673 GTP binding site [chemical binding]; other site 251229014674 Walker B motif; other site 251229014675 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229014676 putative active site [active] 251229014677 Domain of unknown function (DUF897); Region: DUF897; pfam05982 251229014678 Nitrogen regulatory protein P-II; Region: P-II; cl00412 251229014679 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 251229014680 active site clefts [active] 251229014681 zinc binding site [ion binding]; other site 251229014682 dimer interface [polypeptide binding]; other site 251229014683 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 251229014684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229014685 dimer interface [polypeptide binding]; other site 251229014686 conserved gate region; other site 251229014687 putative PBP binding loops; other site 251229014688 ABC-ATPase subunit interface; other site 251229014689 DNA photolyase; Region: DNA_photolyase; pfam00875 251229014690 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 251229014691 heat shock protein 90; Provisional; Region: PRK05218 251229014692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229014693 ATP binding site [chemical binding]; other site 251229014694 Mg2+ binding site [ion binding]; other site 251229014695 G-X-G motif; other site 251229014696 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 251229014697 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 251229014698 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 251229014699 catalytic triad [active] 251229014700 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 251229014701 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 251229014702 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 251229014703 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 251229014704 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 251229014705 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 251229014706 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 251229014707 active site 251229014708 catalytic residues [active] 251229014709 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229014710 GAF domain; Region: GAF; pfam01590 251229014711 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229014712 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 251229014713 GUN4-like; Region: GUN4; pfam05419 251229014714 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 251229014715 isocitrate dehydrogenase; Validated; Region: PRK07362 251229014716 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 251229014717 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229014718 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 251229014719 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229014720 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229014721 active site 251229014722 ATP binding site [chemical binding]; other site 251229014723 substrate binding site [chemical binding]; other site 251229014724 activation loop (A-loop); other site 251229014725 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 251229014726 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 251229014727 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 251229014728 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 251229014729 active site 251229014730 catalytic site [active] 251229014731 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 251229014732 Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468 251229014733 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 251229014734 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 251229014735 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 251229014736 putative active site [active] 251229014737 catalytic residue [active] 251229014738 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 251229014739 Tetratricopeptide repeat; Region: TPR_16; pfam13432 251229014740 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 251229014741 active site 251229014742 dimerization interface [polypeptide binding]; other site 251229014743 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 251229014744 nucleoside/Zn binding site; other site 251229014745 dimer interface [polypeptide binding]; other site 251229014746 catalytic motif [active] 251229014747 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229014748 dimerization interface [polypeptide binding]; other site 251229014749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229014750 dimer interface [polypeptide binding]; other site 251229014751 phosphorylation site [posttranslational modification] 251229014752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229014753 ATP binding site [chemical binding]; other site 251229014754 Mg2+ binding site [ion binding]; other site 251229014755 G-X-G motif; other site 251229014756 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229014757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229014758 active site 251229014759 phosphorylation site [posttranslational modification] 251229014760 intermolecular recognition site; other site 251229014761 dimerization interface [polypeptide binding]; other site 251229014762 Response regulator receiver domain; Region: Response_reg; pfam00072 251229014763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229014764 active site 251229014765 phosphorylation site [posttranslational modification] 251229014766 intermolecular recognition site; other site 251229014767 dimerization interface [polypeptide binding]; other site 251229014768 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 251229014769 putative binding surface; other site 251229014770 active site 251229014771 Response regulator receiver domain; Region: Response_reg; pfam00072 251229014772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229014773 active site 251229014774 phosphorylation site [posttranslational modification] 251229014775 intermolecular recognition site; other site 251229014776 dimerization interface [polypeptide binding]; other site 251229014777 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229014778 PAS fold; Region: PAS_3; pfam08447 251229014779 putative active site [active] 251229014780 heme pocket [chemical binding]; other site 251229014781 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229014782 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229014783 metal binding site [ion binding]; metal-binding site 251229014784 active site 251229014785 I-site; other site 251229014786 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 251229014787 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 251229014788 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 251229014789 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 251229014790 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 251229014791 TM-ABC transporter signature motif; other site 251229014792 protein-L-isoaspartate(D-aspartate) O-methyltransferase; Region: pimt; TIGR00080 251229014793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229014794 S-adenosylmethionine binding site [chemical binding]; other site 251229014795 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 251229014796 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 251229014797 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 251229014798 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 251229014799 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 251229014800 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 251229014801 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 251229014802 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 251229014803 S-layer homology domain; Region: SLH; pfam00395 251229014804 S-layer homology domain; Region: SLH; pfam00395 251229014805 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 251229014806 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 251229014807 translation initiation factor IF-2; Validated; Region: infB; PRK05306 251229014808 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 251229014809 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 251229014810 G1 box; other site 251229014811 putative GEF interaction site [polypeptide binding]; other site 251229014812 GTP/Mg2+ binding site [chemical binding]; other site 251229014813 Switch I region; other site 251229014814 G2 box; other site 251229014815 G3 box; other site 251229014816 Switch II region; other site 251229014817 G4 box; other site 251229014818 G5 box; other site 251229014819 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 251229014820 Translation-initiation factor 2; Region: IF-2; pfam11987 251229014821 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 251229014822 Protein of unknown function (DUF448); Region: DUF448; pfam04296 251229014823 putative RNA binding cleft [nucleotide binding]; other site 251229014824 NusA N-terminal domain; Region: NusA_N; pfam08529 251229014825 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 251229014826 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 251229014827 RNA binding site [nucleotide binding]; other site 251229014828 homodimer interface [polypeptide binding]; other site 251229014829 NusA-like KH domain; Region: KH_5; pfam13184 251229014830 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 251229014831 G-X-X-G motif; other site 251229014832 ribosome maturation protein RimP; Reviewed; Region: PRK00092 251229014833 Sm and related proteins; Region: Sm_like; cl00259 251229014834 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 251229014835 putative oligomer interface [polypeptide binding]; other site 251229014836 putative RNA binding site [nucleotide binding]; other site 251229014837 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 251229014838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229014839 dimer interface [polypeptide binding]; other site 251229014840 conserved gate region; other site 251229014841 putative PBP binding loops; other site 251229014842 ABC-ATPase subunit interface; other site 251229014843 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 251229014844 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 251229014845 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229014846 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229014847 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 251229014848 Family description; Region: UvrD_C_2; pfam13538 251229014849 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 251229014850 active site 251229014851 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 251229014852 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 251229014853 Hemerythrin family; Region: Hemerythrin-like; cl15774 251229014854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 251229014855 conserved hypothetical protein; Region: TIGR03492 251229014856 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229014857 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229014858 active site 251229014859 ATP binding site [chemical binding]; other site 251229014860 substrate binding site [chemical binding]; other site 251229014861 activation loop (A-loop); other site 251229014862 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 251229014863 SNF2 Helicase protein; Region: DUF3670; pfam12419 251229014864 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251229014865 ATP binding site [chemical binding]; other site 251229014866 putative Mg++ binding site [ion binding]; other site 251229014867 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251229014868 nucleotide binding region [chemical binding]; other site 251229014869 ATP-binding site [chemical binding]; other site 251229014870 Uncharacterized conserved protein [Function unknown]; Region: COG4279 251229014871 SWIM zinc finger; Region: SWIM; pfam04434 251229014872 Cupin domain; Region: Cupin_2; cl17218 251229014873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 251229014874 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 251229014875 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 251229014876 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 251229014877 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 251229014878 GatB domain; Region: GatB_Yqey; smart00845 251229014879 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251229014880 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229014881 AMIN domain; Region: AMIN; pfam11741 251229014882 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 251229014883 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229014884 ligand-binding site [chemical binding]; other site 251229014885 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251229014886 AMIN domain; Region: AMIN; pfam11741 251229014887 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 251229014888 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 251229014889 N-terminal plug; other site 251229014890 ligand-binding site [chemical binding]; other site 251229014891 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 251229014892 heterotetramer interface [polypeptide binding]; other site 251229014893 active site pocket [active] 251229014894 cleavage site 251229014895 Response regulator receiver domain; Region: Response_reg; pfam00072 251229014896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229014897 active site 251229014898 phosphorylation site [posttranslational modification] 251229014899 intermolecular recognition site; other site 251229014900 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229014901 dimerization interface [polypeptide binding]; other site 251229014902 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 251229014903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229014904 ATP binding site [chemical binding]; other site 251229014905 Mg2+ binding site [ion binding]; other site 251229014906 G-X-G motif; other site 251229014907 GAF domain; Region: GAF; pfam01590 251229014908 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229014909 PAS domain S-box; Region: sensory_box; TIGR00229 251229014910 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229014911 putative active site [active] 251229014912 heme pocket [chemical binding]; other site 251229014913 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229014914 GAF domain; Region: GAF; cl17456 251229014915 PAS domain S-box; Region: sensory_box; TIGR00229 251229014916 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229014917 putative active site [active] 251229014918 heme pocket [chemical binding]; other site 251229014919 PAS fold; Region: PAS_4; pfam08448 251229014920 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229014921 putative active site [active] 251229014922 heme pocket [chemical binding]; other site 251229014923 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251229014924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229014925 dimer interface [polypeptide binding]; other site 251229014926 phosphorylation site [posttranslational modification] 251229014927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229014928 ATP binding site [chemical binding]; other site 251229014929 Mg2+ binding site [ion binding]; other site 251229014930 G-X-G motif; other site 251229014931 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 251229014932 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 251229014933 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 251229014934 2TM domain; Region: 2TM; pfam13239 251229014935 Response regulator receiver domain; Region: Response_reg; pfam00072 251229014936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229014937 active site 251229014938 phosphorylation site [posttranslational modification] 251229014939 intermolecular recognition site; other site 251229014940 dimerization interface [polypeptide binding]; other site 251229014941 Response regulator receiver domain; Region: Response_reg; pfam00072 251229014942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229014943 active site 251229014944 phosphorylation site [posttranslational modification] 251229014945 intermolecular recognition site; other site 251229014946 dimerization interface [polypeptide binding]; other site 251229014947 Response regulator receiver domain; Region: Response_reg; pfam00072 251229014948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229014949 active site 251229014950 phosphorylation site [posttranslational modification] 251229014951 intermolecular recognition site; other site 251229014952 dimerization interface [polypeptide binding]; other site 251229014953 Response regulator receiver domain; Region: Response_reg; pfam00072 251229014954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229014955 active site 251229014956 phosphorylation site [posttranslational modification] 251229014957 intermolecular recognition site; other site 251229014958 dimerization interface [polypeptide binding]; other site 251229014959 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 251229014960 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 251229014961 substrate binding site [chemical binding]; other site 251229014962 hexamer interface [polypeptide binding]; other site 251229014963 metal binding site [ion binding]; metal-binding site 251229014964 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 251229014965 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 251229014966 dimerization interface [polypeptide binding]; other site 251229014967 domain crossover interface; other site 251229014968 redox-dependent activation switch; other site 251229014969 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 251229014970 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 251229014971 oxidase reductase; Provisional; Region: PTZ00273 251229014972 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 251229014973 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 251229014974 amidase; Provisional; Region: PRK09201 251229014975 Amidase; Region: Amidase; cl11426 251229014976 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 251229014977 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 251229014978 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 251229014979 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229014980 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229014981 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229014982 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229014983 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229014984 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 251229014985 5' RNA guide strand anchoring site; other site 251229014986 active site 251229014987 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 251229014988 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 251229014989 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 251229014990 non-specific DNA binding site [nucleotide binding]; other site 251229014991 salt bridge; other site 251229014992 sequence-specific DNA binding site [nucleotide binding]; other site 251229014993 Domain of unknown function (DUF955); Region: DUF955; pfam06114 251229014994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704 251229014995 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 251229014996 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 251229014997 putative active site [active] 251229014998 catalytic triad [active] 251229014999 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 251229015000 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 251229015001 metal binding site 2 [ion binding]; metal-binding site 251229015002 putative DNA binding helix; other site 251229015003 metal binding site 1 [ion binding]; metal-binding site 251229015004 dimer interface [polypeptide binding]; other site 251229015005 structural Zn2+ binding site [ion binding]; other site 251229015006 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 251229015007 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 251229015008 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 251229015009 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 251229015010 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 251229015011 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 251229015012 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 251229015013 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 251229015014 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 251229015015 Thf1-like protein; Reviewed; Region: PRK13266 251229015016 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 251229015017 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 251229015018 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 251229015019 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 251229015020 Uncharacterized conserved protein [Function unknown]; Region: COG3339 251229015021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229015022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229015023 dimer interface [polypeptide binding]; other site 251229015024 phosphorylation site [posttranslational modification] 251229015025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229015026 ATP binding site [chemical binding]; other site 251229015027 Mg2+ binding site [ion binding]; other site 251229015028 G-X-G motif; other site 251229015029 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229015030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229015031 active site 251229015032 phosphorylation site [posttranslational modification] 251229015033 intermolecular recognition site; other site 251229015034 dimerization interface [polypeptide binding]; other site 251229015035 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 251229015036 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 251229015037 Ferritin-like domain; Region: Ferritin; pfam00210 251229015038 dimanganese center [ion binding]; other site 251229015039 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 251229015040 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 251229015041 putative active site [active] 251229015042 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 251229015043 putative active site [active] 251229015044 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 251229015045 active site 251229015046 SAM binding site [chemical binding]; other site 251229015047 homodimer interface [polypeptide binding]; other site 251229015048 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 251229015049 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 251229015050 putative acetyltransferase; Provisional; Region: PRK03624 251229015051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229015052 Coenzyme A binding pocket [chemical binding]; other site 251229015053 Proline dehydrogenase; Region: Pro_dh; pfam01619 251229015054 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 251229015055 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 251229015056 Glutamate binding site [chemical binding]; other site 251229015057 homodimer interface [polypeptide binding]; other site 251229015058 NAD binding site [chemical binding]; other site 251229015059 catalytic residues [active] 251229015060 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 251229015061 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 251229015062 putative active site; other site 251229015063 catalytic residue [active] 251229015064 aspartate aminotransferase; Provisional; Region: PRK05764 251229015065 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 251229015066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229015067 homodimer interface [polypeptide binding]; other site 251229015068 catalytic residue [active] 251229015069 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 251229015070 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 251229015071 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 251229015072 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 251229015073 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 251229015074 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229015075 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 251229015076 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 251229015077 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 251229015078 NAD binding site [chemical binding]; other site 251229015079 substrate binding site [chemical binding]; other site 251229015080 homodimer interface [polypeptide binding]; other site 251229015081 active site 251229015082 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 251229015083 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229015084 hypothetical protein; Provisional; Region: PRK07208 251229015085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229015086 Predicted membrane protein [Function unknown]; Region: COG2246 251229015087 GtrA-like protein; Region: GtrA; pfam04138 251229015088 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 251229015089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229015090 S-adenosylmethionine binding site [chemical binding]; other site 251229015091 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229015092 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 251229015093 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229015094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229015095 S-adenosylmethionine binding site [chemical binding]; other site 251229015096 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229015097 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 251229015098 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 251229015099 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 251229015100 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229015101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229015102 S-adenosylmethionine binding site [chemical binding]; other site 251229015103 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 251229015104 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 251229015105 active site 251229015106 trimer interface [polypeptide binding]; other site 251229015107 substrate binding site [chemical binding]; other site 251229015108 CoA binding site [chemical binding]; other site 251229015109 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 251229015110 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 251229015111 Walker A/P-loop; other site 251229015112 ATP binding site [chemical binding]; other site 251229015113 Q-loop/lid; other site 251229015114 ABC transporter signature motif; other site 251229015115 Walker B; other site 251229015116 D-loop; other site 251229015117 H-loop/switch region; other site 251229015118 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 251229015119 putative carbohydrate binding site [chemical binding]; other site 251229015120 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 251229015121 ABC-2 type transporter; Region: ABC2_membrane; cl17235 251229015122 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 251229015123 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 251229015124 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 251229015125 Switch I; other site 251229015126 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 251229015127 putative dimer interface [polypeptide binding]; other site 251229015128 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 251229015129 UbiA prenyltransferase family; Region: UbiA; pfam01040 251229015130 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 251229015131 agmatinase; Region: agmatinase; TIGR01230 251229015132 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 251229015133 putative active site [active] 251229015134 Mn binding site [ion binding]; other site 251229015135 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 251229015136 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 251229015137 putative catalytic residue [active] 251229015138 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 251229015139 putative nucleotide binding site [chemical binding]; other site 251229015140 uridine monophosphate binding site [chemical binding]; other site 251229015141 homohexameric interface [polypeptide binding]; other site 251229015142 ribosome recycling factor; Reviewed; Region: frr; PRK00083 251229015143 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 251229015144 hinge region; other site 251229015145 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 251229015146 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229015147 DDE superfamily endonuclease; Region: DDE_3; pfam13358 251229015148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 251229015149 Homeodomain-like domain; Region: HTH_23; pfam13384 251229015150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 251229015151 Winged helix-turn helix; Region: HTH_33; pfam13592 251229015152 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 251229015153 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 251229015154 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 251229015155 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 251229015156 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 251229015157 EVE domain; Region: EVE; pfam01878 251229015158 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 251229015159 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 251229015160 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 251229015161 generic binding surface I; other site 251229015162 generic binding surface II; other site 251229015163 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 251229015164 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 251229015165 active site 251229015166 PHP Thumb interface [polypeptide binding]; other site 251229015167 metal binding site [ion binding]; metal-binding site 251229015168 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 251229015169 protein-splicing catalytic site; other site 251229015170 thioester formation/cholesterol transfer; other site 251229015171 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229015172 putative active site [active] 251229015173 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 251229015174 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 251229015175 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 251229015176 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229015177 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229015178 active site 251229015179 ATP binding site [chemical binding]; other site 251229015180 substrate binding site [chemical binding]; other site 251229015181 activation loop (A-loop); other site 251229015182 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 251229015183 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 251229015184 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 251229015185 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 251229015186 S-layer homology domain; Region: SLH; pfam00395 251229015187 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251229015188 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 251229015189 transmembrane helices; other site 251229015190 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 251229015191 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 251229015192 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 251229015193 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229015194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229015195 ATP binding site [chemical binding]; other site 251229015196 Mg2+ binding site [ion binding]; other site 251229015197 G-X-G motif; other site 251229015198 glycerate kinase; Region: TIGR00045 251229015199 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 251229015200 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 251229015201 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 251229015202 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 251229015203 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 251229015204 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 251229015205 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 251229015206 catalytic site [active] 251229015207 subunit interface [polypeptide binding]; other site 251229015208 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 251229015209 ATP-grasp domain; Region: ATP-grasp_4; cl17255 251229015210 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 251229015211 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 251229015212 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 251229015213 MraW methylase family; Region: Methyltransf_5; cl17771 251229015214 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 251229015215 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 251229015216 active site 251229015217 catalytic site [active] 251229015218 tetramer interface [polypeptide binding]; other site 251229015219 ketol-acid reductoisomerase; Provisional; Region: PRK05479 251229015220 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 251229015221 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 251229015222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229015223 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 251229015224 NAD(P) binding site [chemical binding]; other site 251229015225 active site 251229015226 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 251229015227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 251229015228 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 251229015229 dimerization interface [polypeptide binding]; other site 251229015230 substrate binding pocket [chemical binding]; other site 251229015231 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 251229015232 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 251229015233 substrate binding site [chemical binding]; other site 251229015234 oxyanion hole (OAH) forming residues; other site 251229015235 trimer interface [polypeptide binding]; other site 251229015236 Protein of unknown function (DUF721); Region: DUF721; pfam05258 251229015237 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 251229015238 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 251229015239 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 251229015240 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 251229015241 catalytic residues [active] 251229015242 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 251229015243 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 251229015244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229015245 homodimer interface [polypeptide binding]; other site 251229015246 catalytic residue [active] 251229015247 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229015248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229015249 active site 251229015250 phosphorylation site [posttranslational modification] 251229015251 intermolecular recognition site; other site 251229015252 dimerization interface [polypeptide binding]; other site 251229015253 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 251229015254 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 251229015255 GIY-YIG motif/motif A; other site 251229015256 active site 251229015257 catalytic site [active] 251229015258 putative DNA binding site [nucleotide binding]; other site 251229015259 metal binding site [ion binding]; metal-binding site 251229015260 UvrB/uvrC motif; Region: UVR; pfam02151 251229015261 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 251229015262 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 251229015263 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251229015264 FeS/SAM binding site; other site 251229015265 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 251229015266 oligomerization interface [polypeptide binding]; other site 251229015267 active site 251229015268 metal binding site [ion binding]; metal-binding site 251229015269 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 251229015270 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 251229015271 homodimer interface [polypeptide binding]; other site 251229015272 active site 251229015273 heterodimer interface [polypeptide binding]; other site 251229015274 catalytic residue [active] 251229015275 metal binding site [ion binding]; metal-binding site 251229015276 RbcX protein; Region: RcbX; pfam02341 251229015277 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 251229015278 multimerization interface [polypeptide binding]; other site 251229015279 Uncharacterized conserved protein [Function unknown]; Region: COG5464 251229015280 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 251229015281 ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional; Region: PLN00020 251229015282 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 251229015283 putative multimerization interface [polypeptide binding]; other site 251229015284 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 251229015285 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 251229015286 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 251229015287 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 251229015288 glycogen binding site [chemical binding]; other site 251229015289 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 251229015290 active site 251229015291 catalytic site [active] 251229015292 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 251229015293 sucrose synthase; Region: sucr_synth; TIGR02470 251229015294 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 251229015295 putative ADP-binding pocket [chemical binding]; other site 251229015296 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 251229015297 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 251229015298 active site 251229015299 Zn binding site [ion binding]; other site 251229015300 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 251229015301 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 251229015302 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 251229015303 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 251229015304 Surface antigen; Region: Bac_surface_Ag; pfam01103 251229015305 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251229015306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 251229015307 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251229015308 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229015309 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 251229015310 Walker A/P-loop; other site 251229015311 ATP binding site [chemical binding]; other site 251229015312 Q-loop/lid; other site 251229015313 ABC transporter signature motif; other site 251229015314 Walker B; other site 251229015315 D-loop; other site 251229015316 H-loop/switch region; other site 251229015317 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 251229015318 catalytic core [active] 251229015319 glucokinase; Provisional; Region: glk; PRK00292 251229015320 glucokinase, proteobacterial type; Region: glk; TIGR00749 251229015321 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 251229015322 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 251229015323 DNA binding residues [nucleotide binding] 251229015324 dimer interface [polypeptide binding]; other site 251229015325 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082 251229015326 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 251229015327 CAAX protease self-immunity; Region: Abi; pfam02517 251229015328 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 251229015329 Cupin-like domain; Region: Cupin_8; pfam13621 251229015330 GH3 auxin-responsive promoter; Region: GH3; pfam03321 251229015331 GH3 auxin-responsive promoter; Region: GH3; pfam03321 251229015332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229015333 Major Facilitator Superfamily; Region: MFS_1; pfam07690 251229015334 putative substrate translocation pore; other site 251229015335 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 251229015336 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 251229015337 [2Fe-2S] cluster binding site [ion binding]; other site 251229015338 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 251229015339 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 251229015340 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 251229015341 catalytic residue [active] 251229015342 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 251229015343 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 251229015344 putative NADP binding site [chemical binding]; other site 251229015345 putative substrate binding site [chemical binding]; other site 251229015346 active site 251229015347 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 251229015348 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 251229015349 Walker A/P-loop; other site 251229015350 ATP binding site [chemical binding]; other site 251229015351 Q-loop/lid; other site 251229015352 ABC transporter signature motif; other site 251229015353 Walker B; other site 251229015354 D-loop; other site 251229015355 H-loop/switch region; other site 251229015356 DevC protein; Region: devC; TIGR01185 251229015357 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 251229015358 FtsX-like permease family; Region: FtsX; pfam02687 251229015359 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 251229015360 active site 251229015361 putative DNA-binding cleft [nucleotide binding]; other site 251229015362 dimer interface [polypeptide binding]; other site 251229015363 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 251229015364 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 251229015365 putative substrate binding pocket [chemical binding]; other site 251229015366 dimer interface [polypeptide binding]; other site 251229015367 phosphate binding site [ion binding]; other site 251229015368 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 251229015369 LysE type translocator; Region: LysE; cl00565 251229015370 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 251229015371 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229015372 GAF domain; Region: GAF; pfam01590 251229015373 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229015374 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229015375 metal binding site [ion binding]; metal-binding site 251229015376 active site 251229015377 I-site; other site 251229015378 dihydroorotase; Provisional; Region: PRK07575 251229015379 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 251229015380 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 251229015381 active site 251229015382 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 251229015383 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 251229015384 Catalytic site [active] 251229015385 dihydroorotase; Provisional; Region: PRK07369 251229015386 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 251229015387 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 251229015388 active site 251229015389 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 251229015390 catalytic core [active] 251229015391 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 251229015392 catalytic core [active] 251229015393 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 251229015394 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 251229015395 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 251229015396 metal-binding site [ion binding] 251229015397 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 251229015398 Soluble P-type ATPase [General function prediction only]; Region: COG4087 251229015399 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 251229015400 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 251229015401 phosphopeptide binding site; other site 251229015402 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 251229015403 catalytic site [active] 251229015404 Transposase; Region: DEDD_Tnp_IS110; pfam01548 251229015405 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 251229015406 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 251229015407 hydrolase, alpha/beta fold family protein; Region: PLN02824 251229015408 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 251229015409 amidophosphoribosyltransferase; Provisional; Region: PRK07349 251229015410 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 251229015411 active site 251229015412 tetramer interface [polypeptide binding]; other site 251229015413 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 251229015414 active site 251229015415 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 251229015416 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 251229015417 dimerization interface [polypeptide binding]; other site 251229015418 ATP binding site [chemical binding]; other site 251229015419 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 251229015420 dimerization interface [polypeptide binding]; other site 251229015421 ATP binding site [chemical binding]; other site 251229015422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229015423 Response regulator receiver domain; Region: Response_reg; pfam00072 251229015424 active site 251229015425 phosphorylation site [posttranslational modification] 251229015426 intermolecular recognition site; other site 251229015427 PAS fold; Region: PAS_4; pfam08448 251229015428 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229015429 putative active site [active] 251229015430 heme pocket [chemical binding]; other site 251229015431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229015432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229015433 dimer interface [polypeptide binding]; other site 251229015434 phosphorylation site [posttranslational modification] 251229015435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229015436 ATP binding site [chemical binding]; other site 251229015437 Mg2+ binding site [ion binding]; other site 251229015438 G-X-G motif; other site 251229015439 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229015440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229015441 active site 251229015442 phosphorylation site [posttranslational modification] 251229015443 intermolecular recognition site; other site 251229015444 dimerization interface [polypeptide binding]; other site 251229015445 Response regulator receiver domain; Region: Response_reg; pfam00072 251229015446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229015447 active site 251229015448 phosphorylation site [posttranslational modification] 251229015449 intermolecular recognition site; other site 251229015450 dimerization interface [polypeptide binding]; other site 251229015451 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 251229015452 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229015453 putative active site [active] 251229015454 heme pocket [chemical binding]; other site 251229015455 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229015456 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 251229015457 putative active site [active] 251229015458 heme pocket [chemical binding]; other site 251229015459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229015460 putative active site [active] 251229015461 heme pocket [chemical binding]; other site 251229015462 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229015463 putative active site [active] 251229015464 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 251229015465 heme pocket [chemical binding]; other site 251229015466 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229015467 dimer interface [polypeptide binding]; other site 251229015468 phosphorylation site [posttranslational modification] 251229015469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229015470 ATP binding site [chemical binding]; other site 251229015471 Mg2+ binding site [ion binding]; other site 251229015472 G-X-G motif; other site 251229015473 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 251229015474 ATP adenylyltransferase; Region: ATP_transf; pfam09830 251229015475 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 251229015476 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 251229015477 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 251229015478 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 251229015479 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 251229015480 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 251229015481 lipoyl attachment site [posttranslational modification]; other site 251229015482 glycine dehydrogenase; Provisional; Region: PRK05367 251229015483 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 251229015484 tetramer interface [polypeptide binding]; other site 251229015485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229015486 catalytic residue [active] 251229015487 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 251229015488 tetramer interface [polypeptide binding]; other site 251229015489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229015490 catalytic residue [active] 251229015491 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 251229015492 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 251229015493 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 251229015494 Chromate transporter; Region: Chromate_transp; pfam02417 251229015495 Uncharacterized conserved protein [Function unknown]; Region: COG0398 251229015496 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 251229015497 aspartate kinase; Provisional; Region: PRK07431 251229015498 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 251229015499 putative nucleotide binding site [chemical binding]; other site 251229015500 putative catalytic residues [active] 251229015501 putative Mg ion binding site [ion binding]; other site 251229015502 putative aspartate binding site [chemical binding]; other site 251229015503 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 251229015504 putative allosteric regulatory site; other site 251229015505 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 251229015506 putative allosteric regulatory residue; other site 251229015507 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 251229015508 putative allosteric regulatory site; other site 251229015509 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 251229015510 putative allosteric regulatory residue; other site 251229015511 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229015512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229015513 active site 251229015514 phosphorylation site [posttranslational modification] 251229015515 intermolecular recognition site; other site 251229015516 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229015517 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229015518 dimer interface [polypeptide binding]; other site 251229015519 phosphorylation site [posttranslational modification] 251229015520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229015521 ATP binding site [chemical binding]; other site 251229015522 Mg2+ binding site [ion binding]; other site 251229015523 G-X-G motif; other site 251229015524 Response regulator receiver domain; Region: Response_reg; pfam00072 251229015525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229015526 active site 251229015527 phosphorylation site [posttranslational modification] 251229015528 intermolecular recognition site; other site 251229015529 dimerization interface [polypeptide binding]; other site 251229015530 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 251229015531 GAF domain; Region: GAF; pfam01590 251229015532 Phytochrome region; Region: PHY; pfam00360 251229015533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229015534 dimer interface [polypeptide binding]; other site 251229015535 phosphorylation site [posttranslational modification] 251229015536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229015537 ATP binding site [chemical binding]; other site 251229015538 Mg2+ binding site [ion binding]; other site 251229015539 G-X-G motif; other site 251229015540 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 251229015541 Amidinotransferase; Region: Amidinotransf; cl12043 251229015542 Uncharacterized conserved protein [Function unknown]; Region: COG1915 251229015543 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 251229015544 homodimer interface [polypeptide binding]; other site 251229015545 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 251229015546 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 251229015547 putative dimer interface [polypeptide binding]; other site 251229015548 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 251229015549 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 251229015550 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 251229015551 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 251229015552 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 251229015553 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 251229015554 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229015555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229015556 active site 251229015557 phosphorylation site [posttranslational modification] 251229015558 intermolecular recognition site; other site 251229015559 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229015560 dimerization interface [polypeptide binding]; other site 251229015561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229015562 dimer interface [polypeptide binding]; other site 251229015563 phosphorylation site [posttranslational modification] 251229015564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229015565 ATP binding site [chemical binding]; other site 251229015566 Mg2+ binding site [ion binding]; other site 251229015567 G-X-G motif; other site 251229015568 Response regulator receiver domain; Region: Response_reg; pfam00072 251229015569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229015570 active site 251229015571 phosphorylation site [posttranslational modification] 251229015572 intermolecular recognition site; other site 251229015573 dimerization interface [polypeptide binding]; other site 251229015574 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 251229015575 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229015576 putative active site [active] 251229015577 heme pocket [chemical binding]; other site 251229015578 GAF domain; Region: GAF; pfam01590 251229015579 Phytochrome region; Region: PHY; pfam00360 251229015580 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229015581 dimer interface [polypeptide binding]; other site 251229015582 phosphorylation site [posttranslational modification] 251229015583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229015584 ATP binding site [chemical binding]; other site 251229015585 Mg2+ binding site [ion binding]; other site 251229015586 G-X-G motif; other site 251229015587 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 251229015588 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 251229015589 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 251229015590 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229015591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229015592 active site 251229015593 phosphorylation site [posttranslational modification] 251229015594 intermolecular recognition site; other site 251229015595 dimerization interface [polypeptide binding]; other site 251229015596 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229015597 DNA binding site [nucleotide binding] 251229015598 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 251229015599 putative GSH binding site [chemical binding]; other site 251229015600 catalytic residues [active] 251229015601 BolA-like protein; Region: BolA; pfam01722 251229015602 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 251229015603 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 251229015604 putative acyl-acceptor binding pocket; other site 251229015605 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 251229015606 nucleoside/Zn binding site; other site 251229015607 dimer interface [polypeptide binding]; other site 251229015608 catalytic motif [active] 251229015609 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 251229015610 GSH binding site [chemical binding]; other site 251229015611 catalytic residues [active] 251229015612 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 251229015613 putative hexamer interface [polypeptide binding]; other site 251229015614 putative hexagonal pore; other site 251229015615 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 251229015616 Hexamer interface [polypeptide binding]; other site 251229015617 Hexagonal pore residue; other site 251229015618 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229015619 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 251229015620 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229015621 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229015622 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229015623 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229015624 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229015625 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 251229015626 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 251229015627 putative active site [active] 251229015628 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 251229015629 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 251229015630 tRNA; other site 251229015631 putative tRNA binding site [nucleotide binding]; other site 251229015632 putative NADP binding site [chemical binding]; other site 251229015633 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 251229015634 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 251229015635 active site 251229015636 NTP binding site [chemical binding]; other site 251229015637 metal binding triad [ion binding]; metal-binding site 251229015638 antibiotic binding site [chemical binding]; other site 251229015639 Uncharacterized conserved protein [Function unknown]; Region: COG2361 251229015640 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 251229015641 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 251229015642 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 251229015643 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251229015644 ATP binding site [chemical binding]; other site 251229015645 putative Mg++ binding site [ion binding]; other site 251229015646 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251229015647 nucleotide binding region [chemical binding]; other site 251229015648 ATP-binding site [chemical binding]; other site 251229015649 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 251229015650 HRDC domain; Region: HRDC; pfam00570 251229015651 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 251229015652 DNA binding residues [nucleotide binding] 251229015653 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 251229015654 SinI restriction endonuclease; Region: RE_SinI; pfam09570 251229015655 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 251229015656 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 251229015657 cofactor binding site; other site 251229015658 DNA binding site [nucleotide binding] 251229015659 substrate interaction site [chemical binding]; other site 251229015660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229015661 Response regulator receiver domain; Region: Response_reg; pfam00072 251229015662 active site 251229015663 phosphorylation site [posttranslational modification] 251229015664 intermolecular recognition site; other site 251229015665 dimerization interface [polypeptide binding]; other site 251229015666 Response regulator receiver domain; Region: Response_reg; pfam00072 251229015667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229015668 active site 251229015669 phosphorylation site [posttranslational modification] 251229015670 intermolecular recognition site; other site 251229015671 dimerization interface [polypeptide binding]; other site 251229015672 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 251229015673 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229015674 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229015675 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229015676 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229015677 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229015678 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229015679 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229015680 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229015681 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 251229015682 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 251229015683 dimer interface [polypeptide binding]; other site 251229015684 putative CheW interface [polypeptide binding]; other site 251229015685 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 251229015686 putative binding surface; other site 251229015687 active site 251229015688 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 251229015689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229015690 ATP binding site [chemical binding]; other site 251229015691 Mg2+ binding site [ion binding]; other site 251229015692 G-X-G motif; other site 251229015693 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 251229015694 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229015695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229015696 active site 251229015697 phosphorylation site [posttranslational modification] 251229015698 intermolecular recognition site; other site 251229015699 dimerization interface [polypeptide binding]; other site 251229015700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229015701 Major Facilitator Superfamily; Region: MFS_1; pfam07690 251229015702 putative substrate translocation pore; other site 251229015703 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 251229015704 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 251229015705 FeS/SAM binding site; other site 251229015706 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 251229015707 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 251229015708 ribosomal protein S4(archaeal type)/S9(eukaryote cytosolic type); Region: rpsD_arch; TIGR01018 251229015709 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 251229015710 RNA binding surface [nucleotide binding]; other site 251229015711 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 251229015712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229015713 active site 251229015714 motif I; other site 251229015715 motif II; other site 251229015716 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229015717 DALR anticodon binding domain; Region: DALR_1; smart00836 251229015718 anticodon binding site; other site 251229015719 tRNA binding surface [nucleotide binding]; other site 251229015720 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 251229015721 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 251229015722 putative switch regulator; other site 251229015723 non-specific DNA interactions [nucleotide binding]; other site 251229015724 DNA binding site [nucleotide binding] 251229015725 sequence specific DNA binding site [nucleotide binding]; other site 251229015726 putative cAMP binding site [chemical binding]; other site 251229015727 PBP superfamily domain; Region: PBP_like_2; pfam12849 251229015728 HPP family; Region: HPP; pfam04982 251229015729 Predicted permeases [General function prediction only]; Region: COG0679 251229015730 TPR repeat; Region: TPR_11; pfam13414 251229015731 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 251229015732 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 251229015733 putative ligand binding site [chemical binding]; other site 251229015734 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 251229015735 MgtC family; Region: MgtC; pfam02308 251229015736 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 251229015737 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 251229015738 putative ligand binding site [chemical binding]; other site 251229015739 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229015740 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 251229015741 active site 251229015742 ATP binding site [chemical binding]; other site 251229015743 substrate binding site [chemical binding]; other site 251229015744 activation loop (A-loop); other site 251229015745 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 251229015746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 251229015747 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 251229015748 putative dimerization interface [polypeptide binding]; other site 251229015749 Homeodomain-like domain; Region: HTH_23; pfam13384 251229015750 Winged helix-turn helix; Region: HTH_29; pfam13551 251229015751 Winged helix-turn helix; Region: HTH_33; pfam13592 251229015752 DDE superfamily endonuclease; Region: DDE_3; pfam13358 251229015753 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 251229015754 Predicted membrane protein [Function unknown]; Region: COG4094 251229015755 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 251229015756 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 251229015757 catalytic residues [active] 251229015758 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 251229015759 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 251229015760 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 251229015761 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 251229015762 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 251229015763 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 251229015764 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 251229015765 intersubunit interface [polypeptide binding]; other site 251229015766 active site 251229015767 zinc binding site [ion binding]; other site 251229015768 Na+ binding site [ion binding]; other site 251229015769 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 251229015770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229015771 motif II; other site 251229015772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229015773 Coenzyme A binding pocket [chemical binding]; other site 251229015774 30S ribosomal protein S1; Reviewed; Region: PRK07400 251229015775 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 251229015776 RNA binding site [nucleotide binding]; other site 251229015777 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 251229015778 RNA binding site [nucleotide binding]; other site 251229015779 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 251229015780 RNA binding site [nucleotide binding]; other site 251229015781 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 251229015782 ATP cone domain; Region: ATP-cone; pfam03477 251229015783 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 251229015784 photosystem II 47 kDa protein; Region: psbB; CHL00062 251229015785 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229015786 putative active site [active] 251229015787 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 251229015788 Part of AAA domain; Region: AAA_19; pfam13245 251229015789 Family description; Region: UvrD_C_2; pfam13538 251229015790 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 251229015791 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 251229015792 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 251229015793 MOSC domain; Region: MOSC; pfam03473 251229015794 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 251229015795 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 251229015796 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 251229015797 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229015798 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229015799 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229015800 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229015801 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 251229015802 S-layer homology domain; Region: SLH; pfam00395 251229015803 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 251229015804 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 251229015805 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 251229015806 HSP70 interaction site [polypeptide binding]; other site 251229015807 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 251229015808 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 251229015809 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 251229015810 catalytic residue [active] 251229015811 putative FPP diphosphate binding site; other site 251229015812 putative FPP binding hydrophobic cleft; other site 251229015813 dimer interface [polypeptide binding]; other site 251229015814 putative IPP diphosphate binding site; other site 251229015815 Uncharacterized conserved protein [Function unknown]; Region: COG1624 251229015816 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 251229015817 diaminopimelate decarboxylase; Region: lysA; TIGR01048 251229015818 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 251229015819 active site 251229015820 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 251229015821 substrate binding site [chemical binding]; other site 251229015822 catalytic residues [active] 251229015823 dimer interface [polypeptide binding]; other site 251229015824 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 251229015825 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 251229015826 Coenzyme A binding pocket [chemical binding]; other site 251229015827 Clp protease ATP binding subunit; Region: clpC; CHL00095 251229015828 Clp amino terminal domain; Region: Clp_N; pfam02861 251229015829 Clp amino terminal domain; Region: Clp_N; pfam02861 251229015830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229015831 Walker A motif; other site 251229015832 ATP binding site [chemical binding]; other site 251229015833 Walker B motif; other site 251229015834 arginine finger; other site 251229015835 UvrB/uvrC motif; Region: UVR; pfam02151 251229015836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229015837 Walker A motif; other site 251229015838 ATP binding site [chemical binding]; other site 251229015839 Walker B motif; other site 251229015840 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 251229015841 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 251229015842 active site 251229015843 catalytic triad [active] 251229015844 oxyanion hole [active] 251229015845 GAF domain; Region: GAF; pfam01590 251229015846 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229015847 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229015848 PAS domain; Region: PAS_9; pfam13426 251229015849 putative active site [active] 251229015850 heme pocket [chemical binding]; other site 251229015851 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229015852 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 251229015853 putative active site [active] 251229015854 heme pocket [chemical binding]; other site 251229015855 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 251229015856 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229015857 putative active site [active] 251229015858 heme pocket [chemical binding]; other site 251229015859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229015860 dimer interface [polypeptide binding]; other site 251229015861 phosphorylation site [posttranslational modification] 251229015862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229015863 ATP binding site [chemical binding]; other site 251229015864 Mg2+ binding site [ion binding]; other site 251229015865 G-X-G motif; other site 251229015866 Response regulator receiver domain; Region: Response_reg; pfam00072 251229015867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229015868 active site 251229015869 phosphorylation site [posttranslational modification] 251229015870 intermolecular recognition site; other site 251229015871 dimerization interface [polypeptide binding]; other site 251229015872 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 251229015873 MoaE homodimer interface [polypeptide binding]; other site 251229015874 MoaD interaction [polypeptide binding]; other site 251229015875 active site residues [active] 251229015876 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 251229015877 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229015878 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 251229015879 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 251229015880 Walker A/P-loop; other site 251229015881 ATP binding site [chemical binding]; other site 251229015882 Q-loop/lid; other site 251229015883 ABC transporter signature motif; other site 251229015884 Walker B; other site 251229015885 D-loop; other site 251229015886 H-loop/switch region; other site 251229015887 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 251229015888 Catalytic site; other site 251229015889 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 251229015890 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229015891 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229015892 active site 251229015893 ATP binding site [chemical binding]; other site 251229015894 substrate binding site [chemical binding]; other site 251229015895 activation loop (A-loop); other site 251229015896 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 251229015897 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 251229015898 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 251229015899 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 251229015900 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 251229015901 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 251229015902 putative active site [active] 251229015903 putative dimer interface [polypeptide binding]; other site 251229015904 Predicted transcriptional regulators [Transcription]; Region: COG1695 251229015905 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 251229015906 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 251229015907 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 251229015908 active site 251229015909 SUMO-1 interface [polypeptide binding]; other site 251229015910 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 251229015911 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 251229015912 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 251229015913 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 251229015914 putative NADH binding site [chemical binding]; other site 251229015915 putative active site [active] 251229015916 nudix motif; other site 251229015917 putative metal binding site [ion binding]; other site 251229015918 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 251229015919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229015920 Walker A/P-loop; other site 251229015921 ATP binding site [chemical binding]; other site 251229015922 Q-loop/lid; other site 251229015923 ABC transporter signature motif; other site 251229015924 Walker B; other site 251229015925 D-loop; other site 251229015926 H-loop/switch region; other site 251229015927 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 251229015928 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 251229015929 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 251229015930 putative active site [active] 251229015931 putative metal binding site [ion binding]; other site 251229015932 quinolinate synthetase; Provisional; Region: PRK09375 251229015933 Methyltransferase domain; Region: Methyltransf_23; pfam13489 251229015934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229015935 S-adenosylmethionine binding site [chemical binding]; other site 251229015936 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 251229015937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 251229015938 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 251229015939 active site 251229015940 putative lithium-binding site [ion binding]; other site 251229015941 substrate binding site [chemical binding]; other site 251229015942 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 251229015943 MPN+ (JAMM) motif; other site 251229015944 Zinc-binding site [ion binding]; other site 251229015945 hypothetical protein; Validated; Region: PRK07411 251229015946 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 251229015947 ATP binding site [chemical binding]; other site 251229015948 substrate interface [chemical binding]; other site 251229015949 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 251229015950 active site residue [active] 251229015951 S-adenosylmethionine synthetase; Validated; Region: PRK05250 251229015952 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 251229015953 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 251229015954 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 251229015955 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 251229015956 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 251229015957 NAD(P) binding site [chemical binding]; other site 251229015958 catalytic residues [active] 251229015959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229015960 active site 251229015961 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229015962 phosphorylation site [posttranslational modification] 251229015963 intermolecular recognition site; other site 251229015964 dimerization interface [polypeptide binding]; other site 251229015965 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229015966 dimer interface [polypeptide binding]; other site 251229015967 phosphorylation site [posttranslational modification] 251229015968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229015969 ATP binding site [chemical binding]; other site 251229015970 Mg2+ binding site [ion binding]; other site 251229015971 G-X-G motif; other site 251229015972 urease subunit alpha; Reviewed; Region: ureC; PRK13207 251229015973 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 251229015974 subunit interactions [polypeptide binding]; other site 251229015975 active site 251229015976 flap region; other site 251229015977 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 251229015978 gamma-beta subunit interface [polypeptide binding]; other site 251229015979 alpha-beta subunit interface [polypeptide binding]; other site 251229015980 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 251229015981 Catalytic domain of Protein Kinases; Region: PKc; cd00180 251229015982 active site 251229015983 ATP binding site [chemical binding]; other site 251229015984 substrate binding site [chemical binding]; other site 251229015985 activation loop (A-loop); other site 251229015986 AAA ATPase domain; Region: AAA_16; pfam13191 251229015987 Predicted ATPase [General function prediction only]; Region: COG3899 251229015988 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 251229015989 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 251229015990 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229015991 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229015992 metal binding site [ion binding]; metal-binding site 251229015993 active site 251229015994 I-site; other site 251229015995 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 251229015996 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 251229015997 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 251229015998 M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343 251229015999 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 251229016000 active site 251229016001 catalytic triad [active] 251229016002 oxyanion hole [active] 251229016003 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 251229016004 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 251229016005 Walker A/P-loop; other site 251229016006 ATP binding site [chemical binding]; other site 251229016007 Q-loop/lid; other site 251229016008 ABC transporter signature motif; other site 251229016009 Walker B; other site 251229016010 D-loop; other site 251229016011 H-loop/switch region; other site 251229016012 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 251229016013 ABC-2 type transporter; Region: ABC2_membrane; cl17235 251229016014 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 251229016015 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 251229016016 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 251229016017 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 251229016018 active site 251229016019 dimer interface [polypeptide binding]; other site 251229016020 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 251229016021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229016022 S-adenosylmethionine binding site [chemical binding]; other site 251229016023 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 251229016024 Protein of unknown function (DUF423); Region: DUF423; pfam04241 251229016025 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 251229016026 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 251229016027 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 251229016028 tetrameric interface [polypeptide binding]; other site 251229016029 NAD binding site [chemical binding]; other site 251229016030 catalytic residues [active] 251229016031 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 251229016032 plastocyanin; Provisional; Region: PRK02710 251229016033 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 251229016034 Pantoate-beta-alanine ligase; Region: PanC; cd00560 251229016035 active site 251229016036 ATP-binding site [chemical binding]; other site 251229016037 pantoate-binding site; other site 251229016038 HXXH motif; other site 251229016039 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 251229016040 CMP-binding site; other site 251229016041 The sites determining sugar specificity; other site 251229016042 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 251229016043 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 251229016044 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 251229016045 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 251229016046 dimerization interface [polypeptide binding]; other site 251229016047 putative ATP binding site [chemical binding]; other site 251229016048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229016049 Major Facilitator Superfamily; Region: MFS_1; pfam07690 251229016050 putative substrate translocation pore; other site 251229016051 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 251229016052 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229016053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229016054 Walker A/P-loop; other site 251229016055 ATP binding site [chemical binding]; other site 251229016056 Q-loop/lid; other site 251229016057 ABC transporter signature motif; other site 251229016058 Walker B; other site 251229016059 D-loop; other site 251229016060 H-loop/switch region; other site 251229016061 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 251229016062 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 251229016063 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229016064 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 251229016065 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 251229016066 putative active site [active] 251229016067 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 251229016068 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 251229016069 Walker A/P-loop; other site 251229016070 ATP binding site [chemical binding]; other site 251229016071 Q-loop/lid; other site 251229016072 ABC transporter signature motif; other site 251229016073 Walker B; other site 251229016074 D-loop; other site 251229016075 H-loop/switch region; other site 251229016076 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 251229016077 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 251229016078 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 251229016079 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 251229016080 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 251229016081 GAF domain; Region: GAF; pfam01590 251229016082 Phytochrome region; Region: PHY; pfam00360 251229016083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229016084 dimer interface [polypeptide binding]; other site 251229016085 phosphorylation site [posttranslational modification] 251229016086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229016087 ATP binding site [chemical binding]; other site 251229016088 Mg2+ binding site [ion binding]; other site 251229016089 G-X-G motif; other site 251229016090 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229016091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229016092 active site 251229016093 phosphorylation site [posttranslational modification] 251229016094 intermolecular recognition site; other site 251229016095 dimerization interface [polypeptide binding]; other site 251229016096 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 251229016097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229016098 active site 251229016099 phosphorylation site [posttranslational modification] 251229016100 intermolecular recognition site; other site 251229016101 dimerization interface [polypeptide binding]; other site 251229016102 PAS domain; Region: PAS_9; pfam13426 251229016103 PAS domain; Region: PAS_9; pfam13426 251229016104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229016105 putative active site [active] 251229016106 heme pocket [chemical binding]; other site 251229016107 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229016108 PAS fold; Region: PAS_3; pfam08447 251229016109 putative active site [active] 251229016110 heme pocket [chemical binding]; other site 251229016111 PAS domain S-box; Region: sensory_box; TIGR00229 251229016112 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229016113 putative active site [active] 251229016114 heme pocket [chemical binding]; other site 251229016115 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 251229016116 PAS fold; Region: PAS_3; pfam08447 251229016117 putative active site [active] 251229016118 heme pocket [chemical binding]; other site 251229016119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229016120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229016121 dimer interface [polypeptide binding]; other site 251229016122 phosphorylation site [posttranslational modification] 251229016123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229016124 ATP binding site [chemical binding]; other site 251229016125 Mg2+ binding site [ion binding]; other site 251229016126 G-X-G motif; other site 251229016127 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 251229016128 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 251229016129 substrate binding site [chemical binding]; other site 251229016130 dimer interface [polypeptide binding]; other site 251229016131 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 251229016132 ATP binding site [chemical binding]; other site 251229016133 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 251229016134 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 251229016135 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 251229016136 Walker A/P-loop; other site 251229016137 ATP binding site [chemical binding]; other site 251229016138 Q-loop/lid; other site 251229016139 ABC transporter signature motif; other site 251229016140 Walker B; other site 251229016141 D-loop; other site 251229016142 H-loop/switch region; other site 251229016143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229016144 dimer interface [polypeptide binding]; other site 251229016145 conserved gate region; other site 251229016146 ABC-ATPase subunit interface; other site 251229016147 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 251229016148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229016149 conserved gate region; other site 251229016150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 251229016151 ABC-ATPase subunit interface; other site 251229016152 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 251229016153 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 251229016154 substrate binding pocket [chemical binding]; other site 251229016155 membrane-bound complex binding site; other site 251229016156 hinge residues; other site 251229016157 Phage major coat protein, Gp8; Region: Phage_Coat_Gp8; cl15426 251229016158 Uncharacterized conserved protein [Function unknown]; Region: COG1434 251229016159 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 251229016160 putative active site [active] 251229016161 UV-endonuclease UvdE; Region: UvdE; cl10036 251229016162 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 251229016163 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 251229016164 phage shock protein C; Region: phageshock_pspC; TIGR02978 251229016165 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 251229016166 cobyric acid synthase; Provisional; Region: PRK00784 251229016167 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 251229016168 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 251229016169 catalytic triad [active] 251229016170 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 251229016171 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251229016172 catalytic loop [active] 251229016173 iron binding site [ion binding]; other site 251229016174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229016175 Major Facilitator Superfamily; Region: MFS_1; pfam07690 251229016176 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 251229016177 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 251229016178 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251229016179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229016180 binding surface 251229016181 TPR motif; other site 251229016182 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251229016183 Tetratricopeptide repeat; Region: TPR_12; pfam13424 251229016184 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229016185 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229016186 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 251229016187 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229016188 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 251229016189 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 251229016190 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 251229016191 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251229016192 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 251229016193 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251229016194 DNA binding residues [nucleotide binding] 251229016195 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 251229016196 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 251229016197 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 251229016198 metal-binding heat shock protein; Provisional; Region: PRK00016 251229016199 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 251229016200 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 251229016201 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 251229016202 glutamine binding [chemical binding]; other site 251229016203 catalytic triad [active] 251229016204 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 251229016205 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 251229016206 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 251229016207 hypothetical protein; Validated; Region: PRK07198 251229016208 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 251229016209 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 251229016210 dimerization interface [polypeptide binding]; other site 251229016211 active site 251229016212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229016213 binding surface 251229016214 TPR motif; other site 251229016215 TPR repeat; Region: TPR_11; pfam13414 251229016216 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 251229016217 FAD binding domain; Region: FAD_binding_4; pfam01565 251229016218 Uncharacterized conserved protein [Function unknown]; Region: COG3349 251229016219 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 251229016220 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 251229016221 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229016222 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 251229016223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 251229016224 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 251229016225 putative dimer interface [polypeptide binding]; other site 251229016226 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229016227 ligand binding site [chemical binding]; other site 251229016228 Zn binding site [ion binding]; other site 251229016229 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 251229016230 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 251229016231 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 251229016232 catalytic residue [active] 251229016233 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 251229016234 Uncharacterized conserved protein [Function unknown]; Region: COG0432 251229016235 Uncharacterized conserved protein [Function unknown]; Region: COG0327 251229016236 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 251229016237 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 251229016238 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 251229016239 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 251229016240 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 251229016241 active site 251229016242 DNA binding site [nucleotide binding] 251229016243 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 251229016244 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 251229016245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229016246 S-adenosylmethionine binding site [chemical binding]; other site 251229016247 Protease prsW family; Region: PrsW-protease; pfam13367 251229016248 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 251229016249 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 251229016250 catalytic loop [active] 251229016251 iron binding site [ion binding]; other site 251229016252 photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989 251229016253 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251229016254 Ligand Binding Site [chemical binding]; other site 251229016255 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 251229016256 Ligand Binding Site [chemical binding]; other site 251229016257 S-layer homology domain; Region: SLH; pfam00395 251229016258 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251229016259 Transcriptional regulator; Region: Rrf2; pfam02082 251229016260 Predicted transcriptional regulator [Transcription]; Region: COG1959 251229016261 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 251229016262 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 251229016263 dimer interface [polypeptide binding]; other site 251229016264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 251229016265 catalytic residue [active] 251229016266 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 251229016267 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 251229016268 HSP70 interaction site [polypeptide binding]; other site 251229016269 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 251229016270 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 251229016271 dimerization interface [polypeptide binding]; other site 251229016272 active site 251229016273 arginine-tRNA ligase; Region: PLN02286 251229016274 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 251229016275 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 251229016276 active site 251229016277 HIGH motif; other site 251229016278 KMSK motif region; other site 251229016279 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 251229016280 tRNA binding surface [nucleotide binding]; other site 251229016281 anticodon binding site; other site 251229016282 acetyl-CoA synthetase; Provisional; Region: PTZ00237 251229016283 DAK2 domain; Region: Dak2; cl03685 251229016284 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 251229016285 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 251229016286 Response regulator receiver domain; Region: Response_reg; pfam00072 251229016287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229016288 active site 251229016289 phosphorylation site [posttranslational modification] 251229016290 intermolecular recognition site; other site 251229016291 dimerization interface [polypeptide binding]; other site 251229016292 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 251229016293 active site 251229016294 catalytic residues [active] 251229016295 metal binding site [ion binding]; metal-binding site 251229016296 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 251229016297 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 251229016298 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 251229016299 protein binding site [polypeptide binding]; other site 251229016300 Replication protein; Region: Rep_1; pfam01446 251229016301 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 251229016302 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 251229016303 protein binding site [polypeptide binding]; other site 251229016304 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 251229016305 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 251229016306 Catalytic site [active] 251229016307 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 251229016308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 251229016309 NAD(P) binding site [chemical binding]; other site 251229016310 active site 251229016311 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 251229016312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229016313 Major Facilitator Superfamily; Region: MFS_1; pfam07690 251229016314 putative substrate translocation pore; other site 251229016315 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 251229016316 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 251229016317 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 251229016318 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 251229016319 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 251229016320 transmembrane helices; other site 251229016321 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 251229016322 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 251229016323 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 251229016324 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 251229016325 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 251229016326 metal binding site [ion binding]; metal-binding site 251229016327 active site 251229016328 I-site; other site 251229016329 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 251229016330 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229016331 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229016332 dimer interface [polypeptide binding]; other site 251229016333 phosphorylation site [posttranslational modification] 251229016334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229016335 ATP binding site [chemical binding]; other site 251229016336 Mg2+ binding site [ion binding]; other site 251229016337 G-X-G motif; other site 251229016338 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229016339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229016340 active site 251229016341 phosphorylation site [posttranslational modification] 251229016342 intermolecular recognition site; other site 251229016343 dimerization interface [polypeptide binding]; other site 251229016344 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229016345 DNA binding site [nucleotide binding] 251229016346 CCC1; Region: CCC1; cd02435 251229016347 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 251229016348 dimanganese center [ion binding]; other site 251229016349 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 251229016350 amphipathic channel; other site 251229016351 Asn-Pro-Ala signature motifs; other site 251229016352 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229016353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229016354 active site 251229016355 phosphorylation site [posttranslational modification] 251229016356 intermolecular recognition site; other site 251229016357 dimerization interface [polypeptide binding]; other site 251229016358 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229016359 DNA binding site [nucleotide binding] 251229016360 H+ Antiporter protein; Region: 2A0121; TIGR00900 251229016361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229016362 putative substrate translocation pore; other site 251229016363 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 251229016364 putative homodimer interface [polypeptide binding]; other site 251229016365 putative homotetramer interface [polypeptide binding]; other site 251229016366 putative allosteric switch controlling residues; other site 251229016367 putative metal binding site [ion binding]; other site 251229016368 putative homodimer-homodimer interface [polypeptide binding]; other site 251229016369 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 251229016370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229016371 dimer interface [polypeptide binding]; other site 251229016372 phosphorylation site [posttranslational modification] 251229016373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229016374 ATP binding site [chemical binding]; other site 251229016375 Mg2+ binding site [ion binding]; other site 251229016376 G-X-G motif; other site 251229016377 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229016378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229016379 active site 251229016380 phosphorylation site [posttranslational modification] 251229016381 intermolecular recognition site; other site 251229016382 dimerization interface [polypeptide binding]; other site 251229016383 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229016384 DNA binding site [nucleotide binding] 251229016385 XamI restriction endonuclease; Region: RE_XamI; pfam09572 251229016386 Methyltransferase domain; Region: Methyltransf_26; pfam13659 251229016387 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 251229016388 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 251229016389 Multicopper oxidase; Region: Cu-oxidase; pfam00394 251229016390 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 251229016391 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 251229016392 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 251229016393 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 251229016394 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229016395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 251229016396 Domain of unknown function (DUF305); Region: DUF305; pfam03713 251229016397 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 251229016398 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 251229016399 Soluble P-type ATPase [General function prediction only]; Region: COG4087 251229016400 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 251229016401 catalytic residue [active] 251229016402 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 251229016403 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 251229016404 DNA binding residues [nucleotide binding] 251229016405 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082 251229016406 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 251229016407 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 251229016408 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 251229016409 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 251229016410 motif II; other site 251229016411 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 251229016412 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 251229016413 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 251229016414 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 251229016415 glutathione reductase; Validated; Region: PRK06116 251229016416 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 251229016417 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 251229016418 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 251229016419 flavodoxin FldA; Validated; Region: PRK09267 251229016420 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 251229016421 oligomer interface [polypeptide binding]; other site 251229016422 Homeodomain-like domain; Region: HTH_23; pfam13384 251229016423 Winged helix-turn helix; Region: HTH_29; pfam13551 251229016424 Homeodomain-like domain; Region: HTH_32; pfam13565 251229016425 DDE superfamily endonuclease; Region: DDE_3; pfam13358 251229016426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 251229016427 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 251229016428 dimerization interface [polypeptide binding]; other site 251229016429 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 251229016430 dimerization interface [polypeptide binding]; other site 251229016431 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 251229016432 metal-binding site [ion binding] 251229016433 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 251229016434 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 251229016435 metal-binding site [ion binding] 251229016436 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 251229016437 Soluble P-type ATPase [General function prediction only]; Region: COG4087 251229016438 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 251229016439 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 251229016440 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 251229016441 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 251229016442 DNA binding residues [nucleotide binding] 251229016443 dimer interface [polypeptide binding]; other site 251229016444 metal binding site [ion binding]; metal-binding site 251229016445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229016446 S-adenosylmethionine binding site [chemical binding]; other site 251229016447 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 251229016448 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251229016449 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251229016450 DNA binding residues [nucleotide binding] 251229016451 SnoaL-like domain; Region: SnoaL_2; pfam12680 251229016452 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 251229016453 Methyltransferase domain; Region: Methyltransf_31; pfam13847 251229016454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229016455 S-adenosylmethionine binding site [chemical binding]; other site 251229016456 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 251229016457 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 251229016458 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 251229016459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229016460 TPR motif; other site 251229016461 binding surface 251229016462 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251229016463 DNA binding residues [nucleotide binding] 251229016464 dimerization interface [polypeptide binding]; other site 251229016465 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 251229016466 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 251229016467 dimer interface [polypeptide binding]; other site 251229016468 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 251229016469 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 251229016470 Transposase IS200 like; Region: Y1_Tnp; pfam01797 251229016471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229016472 S-adenosylmethionine binding site [chemical binding]; other site 251229016473 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 251229016474 Domain of unknown function DUF20; Region: UPF0118; pfam01594 251229016475 Predicted membrane protein [Function unknown]; Region: COG1950 251229016476 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 251229016477 Mechanosensitive ion channel; Region: MS_channel; pfam00924 251229016478 TPR repeat; Region: TPR_11; pfam13414 251229016479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 251229016480 binding surface 251229016481 TPR repeat; Region: TPR_11; pfam13414 251229016482 TPR motif; other site 251229016483 TPR repeat; Region: TPR_11; pfam13414 251229016484 TPR repeat; Region: TPR_11; pfam13414 251229016485 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 251229016486 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 251229016487 iron-sulfur cluster [ion binding]; other site 251229016488 [2Fe-2S] cluster binding site [ion binding]; other site 251229016489 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 251229016490 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 251229016491 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 251229016492 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 251229016493 hypothetical protein; Provisional; Region: PRK02237 251229016494 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251229016495 dimerization interface [polypeptide binding]; other site 251229016496 putative DNA binding site [nucleotide binding]; other site 251229016497 putative Zn2+ binding site [ion binding]; other site 251229016498 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 251229016499 metal-binding site [ion binding] 251229016500 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 251229016501 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 251229016502 metal-binding site [ion binding] 251229016503 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 251229016504 Soluble P-type ATPase [General function prediction only]; Region: COG4087 251229016505 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 251229016506 substrate binding site [chemical binding]; other site 251229016507 putative active site [active] 251229016508 redox center [active] 251229016509 Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI...; Region: PDI_a_family; cd02961 251229016510 catalytic residues [active] 251229016511 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 251229016512 Predicted metal-binding protein [General function prediction only]; Region: COG3019 251229016513 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 251229016514 catalytic residue [active] 251229016515 Domain of unknown function (DUF305); Region: DUF305; pfam03713 251229016516 Sporulation and spore germination; Region: Germane; pfam10646 251229016517 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251229016518 dimerization interface [polypeptide binding]; other site 251229016519 putative DNA binding site [nucleotide binding]; other site 251229016520 putative Zn2+ binding site [ion binding]; other site 251229016521 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 251229016522 substrate binding site [chemical binding]; other site 251229016523 putative active site [active] 251229016524 redox center [active] 251229016525 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 251229016526 S-layer homology domain; Region: SLH; pfam00395 251229016527 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251229016528 S-layer homology domain; Region: SLH; pfam00395 251229016529 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 251229016530 Probable transposase; Region: OrfB_IS605; pfam01385 251229016531 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 251229016532 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 251229016533 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 251229016534 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229016535 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 251229016536 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 251229016537 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229016538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229016539 active site 251229016540 phosphorylation site [posttranslational modification] 251229016541 intermolecular recognition site; other site 251229016542 dimerization interface [polypeptide binding]; other site 251229016543 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229016544 DNA binding site [nucleotide binding] 251229016545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229016546 dimer interface [polypeptide binding]; other site 251229016547 phosphorylation site [posttranslational modification] 251229016548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229016549 ATP binding site [chemical binding]; other site 251229016550 Mg2+ binding site [ion binding]; other site 251229016551 G-X-G motif; other site 251229016552 proton extrusion protein PcxA; Provisional; Region: PRK02507 251229016553 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 251229016554 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 251229016555 Homeodomain-like domain; Region: HTH_23; pfam13384 251229016556 Winged helix-turn helix; Region: HTH_29; pfam13551 251229016557 Homeodomain-like domain; Region: HTH_32; pfam13565 251229016558 DDE superfamily endonuclease; Region: DDE_3; pfam13358 251229016559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 251229016560 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 251229016561 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 251229016562 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251229016563 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 251229016564 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251229016565 DNA binding residues [nucleotide binding] 251229016566 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 251229016567 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 251229016568 Peptidase family M23; Region: Peptidase_M23; pfam01551 251229016569 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 251229016570 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 251229016571 Soluble P-type ATPase [General function prediction only]; Region: COG4087 251229016572 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 251229016573 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 251229016574 putative lipid kinase; Reviewed; Region: PRK13057 251229016575 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 251229016576 Putative phosphatase (DUF442); Region: DUF442; cl17385 251229016577 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 251229016578 dimerization interface [polypeptide binding]; other site 251229016579 putative DNA binding site [nucleotide binding]; other site 251229016580 putative Zn2+ binding site [ion binding]; other site 251229016581 PcfJ-like protein; Region: PcfJ; pfam14284 251229016582 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 251229016583 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 251229016584 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 251229016585 dimer interface [polypeptide binding]; other site 251229016586 ssDNA binding site [nucleotide binding]; other site 251229016587 tetramer (dimer of dimers) interface [polypeptide binding]; other site 251229016588 ParA-like protein; Provisional; Region: PHA02518 251229016589 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 251229016590 P-loop; other site 251229016591 Magnesium ion binding site [ion binding]; other site 251229016592 ParB-like nuclease domain; Region: ParBc; pfam02195 251229016593 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 251229016594 Toprim-like; Region: Toprim_2; pfam13155 251229016595 active site 251229016596 metal binding site [ion binding]; metal-binding site 251229016597 AAA ATPase domain; Region: AAA_16; pfam13191 251229016598 NACHT domain; Region: NACHT; pfam05729 251229016599 WD40 repeats; Region: WD40; smart00320 251229016600 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229016601 structural tetrad; other site 251229016602 FOG: WD40 repeat [General function prediction only]; Region: COG2319 251229016603 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 251229016604 structural tetrad; other site 251229016605 WD40 repeats; Region: WD40; smart00320 251229016606 Isochorismatase family; Region: Isochorismatase; pfam00857 251229016607 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 251229016608 catalytic triad [active] 251229016609 dimer interface [polypeptide binding]; other site 251229016610 conserved cis-peptide bond; other site 251229016611 S-layer homology domain; Region: SLH; pfam00395 251229016612 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 251229016613 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 251229016614 Rubredoxin; Region: Rubredoxin; pfam00301 251229016615 iron binding site [ion binding]; other site 251229016616 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251229016617 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251229016618 DNA binding residues [nucleotide binding] 251229016619 dimerization interface [polypeptide binding]; other site 251229016620 short chain dehydrogenase; Provisional; Region: PRK06172 251229016621 classical (c) SDRs; Region: SDR_c; cd05233 251229016622 NAD(P) binding site [chemical binding]; other site 251229016623 active site 251229016624 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 251229016625 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 251229016626 putative NAD(P) binding site [chemical binding]; other site 251229016627 AAA domain; Region: AAA_22; pfam13401 251229016628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 251229016629 Walker A motif; other site 251229016630 ATP binding site [chemical binding]; other site 251229016631 Walker B motif; other site 251229016632 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 251229016633 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 251229016634 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229016635 putative active site [active] 251229016636 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 251229016637 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 251229016638 active site 251229016639 DNA binding site [nucleotide binding] 251229016640 Int/Topo IB signature motif; other site 251229016641 TIGR04255 family protein; Region: sporadTIGR04255 251229016642 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 251229016643 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 251229016644 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 251229016645 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 251229016646 Domain of unknown function (DUF955); Region: DUF955; pfam06114 251229016647 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 251229016648 Helix-turn-helix domain; Region: HTH_17; pfam12728 251229016649 RES domain; Region: RES; pfam08808 251229016650 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 251229016651 Probable transposase; Region: OrfB_IS605; pfam01385 251229016652 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 251229016653 Uncharacterized conserved protein (DUF2349); Region: DUF2349; pfam09779 251229016654 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229016655 putative active site [active] 251229016656 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 251229016657 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 251229016658 Mg binding site [ion binding]; other site 251229016659 nucleotide binding site [chemical binding]; other site 251229016660 putative protofilament interface [polypeptide binding]; other site 251229016661 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 251229016662 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 251229016663 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 251229016664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 251229016665 AAA domain; Region: AAA_33; pfam13671 251229016666 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 251229016667 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 251229016668 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229016669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229016670 ATP binding site [chemical binding]; other site 251229016671 Mg2+ binding site [ion binding]; other site 251229016672 G-X-G motif; other site 251229016673 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 251229016674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229016675 active site 251229016676 phosphorylation site [posttranslational modification] 251229016677 intermolecular recognition site; other site 251229016678 dimerization interface [polypeptide binding]; other site 251229016679 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 251229016680 DNA binding residues [nucleotide binding] 251229016681 dimerization interface [polypeptide binding]; other site 251229016682 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 251229016683 Cytochrome P450; Region: p450; pfam00067 251229016684 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251229016685 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 251229016686 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 251229016687 RRXRR protein; Region: RRXRR; pfam14239 251229016688 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 251229016689 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 251229016690 active site 251229016691 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 251229016692 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 251229016693 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 251229016694 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229016695 putative active site [active] 251229016696 RRXRR protein; Region: RRXRR; pfam14239 251229016697 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 251229016698 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 251229016699 active site 251229016700 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 251229016701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229016702 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 251229016703 Walker A motif; other site 251229016704 ATP binding site [chemical binding]; other site 251229016705 Walker B motif; other site 251229016706 arginine finger; other site 251229016707 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 251229016708 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 251229016709 Uncharacterized conserved protein [Function unknown]; Region: COG3791 251229016710 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 251229016711 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229016712 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229016713 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 251229016714 dimer interface [polypeptide binding]; other site 251229016715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 251229016716 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 251229016717 SnoaL-like domain; Region: SnoaL_3; pfam13474 251229016718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 251229016719 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 251229016720 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 251229016721 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229016722 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 251229016723 putative dimer interface [polypeptide binding]; other site 251229016724 ligand binding site [chemical binding]; other site 251229016725 Zn binding site [ion binding]; other site 251229016726 Uncharacterized conserved protein [Function unknown]; Region: COG3791 251229016727 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 251229016728 PIN domain; Region: PIN_2; cl17859 251229016729 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 251229016730 RNA binding site [nucleotide binding]; other site 251229016731 Winged helix-turn helix; Region: HTH_29; pfam13551 251229016732 Helix-turn-helix domain; Region: HTH_28; pfam13518 251229016733 Winged helix-turn helix; Region: HTH_33; pfam13592 251229016734 DDE superfamily endonuclease; Region: DDE_3; pfam13358 251229016735 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 251229016736 PIN domain; Region: PIN_3; pfam13470 251229016737 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 251229016738 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 251229016739 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 251229016740 Catalytic site [active] 251229016741 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 251229016742 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 251229016743 active site 251229016744 DNA binding site [nucleotide binding] 251229016745 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 251229016746 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 251229016747 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 251229016748 active site 251229016749 catalytic site [active] 251229016750 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 251229016751 AAA-like domain; Region: AAA_10; pfam12846 251229016752 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 251229016753 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 251229016754 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 251229016755 Walker A motif; other site 251229016756 ATP binding site [chemical binding]; other site 251229016757 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 251229016758 Walker B motif; other site 251229016759 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 251229016760 polymerase nucleotide-binding site; other site 251229016761 DNA-binding residues [nucleotide binding]; DNA binding site 251229016762 nucleotide binding site [chemical binding]; other site 251229016763 primase nucleotide-binding site [nucleotide binding]; other site 251229016764 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 251229016765 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 251229016766 Transposase IS200 like; Region: Y1_Tnp; pfam01797 251229016767 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 251229016768 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 251229016769 Probable transposase; Region: OrfB_IS605; pfam01385 251229016770 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 251229016771 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 251229016772 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 251229016773 metal ion-dependent adhesion site (MIDAS); other site 251229016774 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 251229016775 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 251229016776 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 251229016777 sequence-specific DNA binding site [nucleotide binding]; other site 251229016778 salt bridge; other site 251229016779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229016780 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 251229016781 Walker A motif; other site 251229016782 ATP binding site [chemical binding]; other site 251229016783 Walker B motif; other site 251229016784 arginine finger; other site 251229016785 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 251229016786 putative active site [active] 251229016787 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 251229016788 active site 251229016789 Int/Topo IB signature motif; other site 251229016790 DNA binding site [nucleotide binding] 251229016791 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 251229016792 active site 251229016793 catalytic residues [active] 251229016794 DNA binding site [nucleotide binding] 251229016795 Int/Topo IB signature motif; other site 251229016796 Predicted transcriptional regulators [Transcription]; Region: COG1695 251229016797 Transcriptional regulator PadR-like family; Region: PadR; cl17335 251229016798 SprT-like family; Region: SprT-like; pfam10263 251229016799 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 251229016800 dimerization interface [polypeptide binding]; other site 251229016801 active site 251229016802 metal binding site [ion binding]; metal-binding site 251229016803 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 251229016804 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 251229016805 dimerization interface [polypeptide binding]; other site 251229016806 active site 251229016807 metal binding site [ion binding]; metal-binding site 251229016808 GUN4-like; Region: GUN4; pfam05419 251229016809 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 251229016810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 251229016811 non-specific DNA binding site [nucleotide binding]; other site 251229016812 salt bridge; other site 251229016813 sequence-specific DNA binding site [nucleotide binding]; other site 251229016814 DEAD-like helicases superfamily; Region: DEXDc; smart00487 251229016815 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251229016816 ATP binding site [chemical binding]; other site 251229016817 putative Mg++ binding site [ion binding]; other site 251229016818 TraE protein; Region: TraE; cl05060 251229016819 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251229016820 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 251229016821 nucleotide binding region [chemical binding]; other site 251229016822 ATP-binding site [chemical binding]; other site 251229016823 Methyltransferase domain; Region: Methyltransf_26; pfam13659 251229016824 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 251229016825 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 251229016826 Uncharacterized conserved protein [Function unknown]; Region: COG5464 251229016827 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 251229016828 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 251229016829 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 251229016830 putative active site [active] 251229016831 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 251229016832 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 251229016833 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 251229016834 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 251229016835 ATP binding site [chemical binding]; other site 251229016836 putative Mg++ binding site [ion binding]; other site 251229016837 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 251229016838 ATP-binding site [chemical binding]; other site 251229016839 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 251229016840 PRTRC system protein A; Region: PRTRC_A; TIGR03735 251229016841 PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736 251229016842 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 251229016843 ATP binding site [chemical binding]; other site 251229016844 substrate interface [chemical binding]; other site 251229016845 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 251229016846 DNA polymerase III subunit beta; Validated; Region: PRK05643 251229016847 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 251229016848 putative DNA binding surface [nucleotide binding]; other site 251229016849 dimer interface [polypeptide binding]; other site 251229016850 beta-clamp/clamp loader binding surface; other site 251229016851 beta-clamp/translesion DNA polymerase binding surface; other site 251229016852 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 251229016853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 251229016854 Walker A motif; other site 251229016855 ATP binding site [chemical binding]; other site 251229016856 Walker B motif; other site 251229016857 arginine finger; other site 251229016858 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 251229016859 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 251229016860 DNA polymerase type-B family; Region: POLBc; smart00486 251229016861 active site 251229016862 catalytic site [active] 251229016863 substrate binding site [chemical binding]; other site 251229016864 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 251229016865 active site 251229016866 metal-binding site 251229016867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 251229016868 S-adenosylmethionine binding site [chemical binding]; other site 251229016869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 251229016870 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 251229016871 active site 251229016872 GIY-YIG motif/motif A; other site 251229016873 catalytic site [active] 251229016874 metal binding site [ion binding]; metal-binding site 251229016875 DNA polymerase III subunit delta; Validated; Region: PRK07452 251229016876 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 251229016877 DNA polymerase III subunit delta'; Validated; Region: PRK07399 251229016878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 251229016879 Walker A motif; other site 251229016880 ATP binding site [chemical binding]; other site 251229016881 Walker B motif; other site 251229016882 arginine finger; other site 251229016883 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 251229016884 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 251229016885 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229016886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229016887 active site 251229016888 phosphorylation site [posttranslational modification] 251229016889 intermolecular recognition site; other site 251229016890 dimerization interface [polypeptide binding]; other site 251229016891 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229016892 DNA binding site [nucleotide binding] 251229016893 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229016894 dimer interface [polypeptide binding]; other site 251229016895 phosphorylation site [posttranslational modification] 251229016896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229016897 ATP binding site [chemical binding]; other site 251229016898 Mg2+ binding site [ion binding]; other site 251229016899 G-X-G motif; other site 251229016900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 251229016901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 251229016902 active site 251229016903 phosphorylation site [posttranslational modification] 251229016904 intermolecular recognition site; other site 251229016905 dimerization interface [polypeptide binding]; other site 251229016906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 251229016907 DNA binding site [nucleotide binding] 251229016908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229016909 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 251229016910 dimerization interface [polypeptide binding]; other site 251229016911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229016912 dimer interface [polypeptide binding]; other site 251229016913 phosphorylation site [posttranslational modification] 251229016914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229016915 ATP binding site [chemical binding]; other site 251229016916 Mg2+ binding site [ion binding]; other site 251229016917 G-X-G motif; other site 251229016918 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 251229016919 active site 251229016920 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229016921 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 251229016922 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 251229016923 active site 251229016924 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 251229016925 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 251229016926 Multicopper oxidase; Region: Cu-oxidase; pfam00394 251229016927 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 251229016928 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 251229016929 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 251229016930 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 251229016931 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 251229016932 Predicted integral membrane protein [Function unknown]; Region: COG0392 251229016933 Uncharacterized conserved protein [Function unknown]; Region: COG2898 251229016934 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 251229016935 Putative esterase; Region: Esterase; pfam00756 251229016936 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 251229016937 RNA recognition motif; Region: RRM; smart00360 251229016938 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 251229016939 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 251229016940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229016941 Major Facilitator Superfamily; Region: MFS_1; pfam07690 251229016942 putative substrate translocation pore; other site 251229016943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 251229016944 putative substrate translocation pore; other site 251229016945 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 251229016946 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 251229016947 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 251229016948 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 251229016949 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 251229016950 RNA polymerase sigma factor; Validated; Region: PRK05949 251229016951 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 251229016952 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 251229016953 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 251229016954 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 251229016955 DNA binding residues [nucleotide binding] 251229016956 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 251229016957 hydrophobic ligand binding site; other site 251229016958 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 251229016959 Beta-lactamase; Region: Beta-lactamase; pfam00144 251229016960 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 251229016961 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 251229016962 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 251229016963 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 251229016964 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 251229016965 HlyD family secretion protein; Region: HlyD_3; pfam13437 251229016966 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 251229016967 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 251229016968 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 251229016969 active site 251229016970 metal binding site [ion binding]; metal-binding site 251229016971 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 251229016972 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 251229016973 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 251229016974 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 251229016975 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 251229016976 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 251229016977 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 251229016978 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 251229016979 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 251229016980 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 251229016981 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 251229016982 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 251229016983 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 251229016984 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 251229016985 Surface antigen; Region: Bac_surface_Ag; pfam01103 251229016986 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 251229016987 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 251229016988 Walker A/P-loop; other site 251229016989 ATP binding site [chemical binding]; other site 251229016990 Q-loop/lid; other site 251229016991 ABC transporter signature motif; other site 251229016992 Walker B; other site 251229016993 D-loop; other site 251229016994 H-loop/switch region; other site 251229016995 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 251229016996 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 251229016997 Walker A/P-loop; other site 251229016998 ATP binding site [chemical binding]; other site 251229016999 Q-loop/lid; other site 251229017000 ABC transporter signature motif; other site 251229017001 Walker B; other site 251229017002 D-loop; other site 251229017003 H-loop/switch region; other site 251229017004 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 251229017005 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 251229017006 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 251229017007 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 251229017008 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 251229017009 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 251229017010 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 251229017011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 251229017012 dimer interface [polypeptide binding]; other site 251229017013 phosphorylation site [posttranslational modification] 251229017014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 251229017015 ATP binding site [chemical binding]; other site 251229017016 Mg2+ binding site [ion binding]; other site 251229017017 G-X-G motif; other site 251229017018 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 251229017019 DDE superfamily endonuclease; Region: DDE_5; cl17874 251229017020 DDE superfamily endonuclease; Region: DDE_5; cl17874 251229017021 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 251229017022 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 251229017023 Predicted membrane protein [Function unknown]; Region: COG2119 251229017024 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 251229017025 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169