-- dump date 20140619_041952 -- class Genbank::CDS -- table cds_note -- id note YP_001451616.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001451617.1 Psort location: mitochondrial, score: 23 YP_001451618.1 KEGG: eca:ECA4418 4.8e-61 dgoK; 2-dehydro-3-deoxygalactonokinase K00883; COG: COG3734 2-keto-3-deoxy-galactonokinase; Psort location: cytoplasmic, score: 23 YP_001451619.1 KEGG: rso:RSc2752 1.9e-57 dgoAa, RS00102; keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase K01631; COG: COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase; Psort location: cytoplasmic, score: 23 YP_001451620.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate YP_001451621.1 membrane protein regulates uhpT expression YP_001451622.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph YP_001451623.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter YP_001451624.1 KEGG: pmu:PM0508 9.9e-22 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 3-sialyltransferase K00785; COG: NOG15044 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001451625.1 Psort location: cytoplasmic, score: 23 YP_001451626.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit YP_001451627.1 KEGG: ecc:c4596 1.6e-284 ilvB; acetolactate synthase isozyme I large subunit K01652; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Psort location: cytoplasmic, score: 23 YP_001451628.1 Psort location: cytoplasmic, score: 23 YP_001451629.1 Psort location: nuclear, score: 23 YP_001451630.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001451631.1 Psort location: mitochondrial, score: 23 YP_001451632.1 multidrug efflux protein involved in adaptation to low energy shock YP_001451633.1 KEGG: bja:blr3367 3.7e-07 probable cellulase K01179; COG: NOG14136 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001451634.1 regulates the synthesis and expression of the dsdXA operon and dadA gene YP_001451635.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function YP_001451636.1 catalyzes the formation of pyruvate from serine YP_001451637.1 KEGG: syg:sync_2368 3.1e-16 arylsulfatase regulator; COG: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); Psort location: cytoplasmic, score: 23 YP_001451638.1 COG: NOG09782 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001451639.1 KEGG: cal:orf19.201 5.6e-06 CDC47; DNA helicase and DNA replication licensing factor K02210; COG: COG2149 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001451640.1 KEGG: ecj:JW3654 1.3e-264 yidJ; predicted sulfatase/phosphatase; COG: COG3119 Arylsulfatase A and related enzymes; Psort location: cytoplasmic, score: 23 YP_001451641.1 uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function YP_001451642.1 KEGG: bha:BH0394 1.2e-07 adaA; methylphosphotriester-DNA alkyltransferase (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: endoplasmic reticulum, score: 9 YP_001451643.1 KEGG: sdy:SDY_4168 2.9e-221 putative 6-phospho-beta-glucosidase K01222; COG: COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001451644.1 KEGG: ssn:SSO_3634 3.5e-248 glvC; phosphotransferase system enzyme IIBC component K02749:K02750; COG: COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific; Psort location: endoplasmic reticulum, score: 9 YP_001451645.1 KEGG: btk:BT9727_3183 7.5e-24 transcriptional regulator, GntR family; COG: COG2188 Transcriptional regulators; Psort location: mitochondrial, score: 23 YP_001451646.1 COG: COG2985 Predicted permease; Psort location: plasma membrane, score: 23 YP_001451647.1 Psort location: cytoplasmic, score: 23 YP_001451648.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent YP_001451649.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress YP_001451650.1 Psort location: cytoplasmic, score: 23 YP_001451651.1 Psort location: nuclear, score: 23 YP_001451652.1 KEGG: aci:ACIAD3598 0.0040 putative glucose dehydrogenase precursor K00120; COG: COG5645 Predicted periplasmic lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001451653.1 KEGG: eci:UTI89_C4240 9.5e-191 yidR; hypothetical protein YidR; COG: NOG06296 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001451654.1 COG: COG3016 Uncharacterized iron-regulated protein; Psort location: extracellular, including cell wall, score: 9 YP_001451655.1 COG: COG0810 Periplasmic protein TonB, links inner and outer membranes; Psort location: nuclear, score: 23 YP_001451656.1 COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: extracellular, including cell wall, score: 9 YP_001451657.1 Psort location: nuclear, score: 23 YP_001451658.1 COG: COG3391 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001451659.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins YP_001451660.1 negatively supercoils closed circular double-stranded DNA YP_001451661.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_001451662.1 binds the polymerase to DNA and acts as a sliding clamp YP_001451663.1 KEGG: shn:Shewana3_0009 2.5e-183 chromosomal replication initiator protein DnaA K00972; COG: COG0593 ATPase involved in DNA replication initiation; Psort location: cytoplasmic, score: 23 YP_001451664.1 Psort location: nuclear, score: 23 YP_001451665.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_001451666.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_001451667.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001451668.1 Psort location: mitochondrial, score: 23 YP_001451669.1 Confers resistance to chloramphenicol YP_001451670.1 Involved in anaerobic NO protection YP_001451671.1 KEGG: sty:STY4228 0.00075 4'-phosphopantetheinyl transferase K06133; COG: COG2091 Phosphopantetheinyl transferase; Psort location: cytoplasmic, score: 23 YP_001451672.1 KEGG: eci:UTI89_C4266 8.3e-89 yieF; hypothetical protein; COG: COG0431 Predicted flavoprotein; Psort location: cytoplasmic, score: 23 YP_001451673.1 Psort location: nuclear, score: 23 YP_001451674.1 KEGG: bcz:BCZK0244 2.4e-89 guanine-hypoxanTHIne permease; xanTHIne/uracil permease family protein K06901; COG: COG2252 Permeases; Psort location: plasma membrane, score: 23 YP_001451675.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily YP_001451676.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon YP_001451677.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_001451678.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_001451679.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_001451680.1 KEGG: mst:Msp_0343 3.4e-08 pstS; PstS K02040; COG: COG0226 ABC-type phosphate transport system, periplasmic component; Psort location: cytoplasmic, score: 23 YP_001451681.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_001451682.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_001451683.1 Psort location: nuclear, score: 23 YP_001451684.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_001451685.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001451686.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_001451687.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001451688.1 Psort location: cytoplasmic, score: 23 YP_001451689.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_001451690.1 Psort location: nuclear, score: 23 YP_001451691.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_001451692.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_001451693.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_001451694.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation YP_001451695.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_001451696.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001451697.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001451698.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase YP_001451699.1 catalyzes the formation of asparagine from aspartate and ammonia YP_001451700.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA YP_001451701.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase YP_001451702.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH YP_001451703.1 COG: COG1869 ABC-type ribose transport system, auxiliary component; Psort location: cytoplasmic, score: 23 YP_001451704.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain YP_001451705.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B YP_001451706.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system YP_001451707.1 catalyzes the formation of D-ribose 5-phosphate from ribose YP_001451708.1 DNA-binding transcriptional repressor of ribose metabolism YP_001451709.1 KEGG: sgl:SG1466 2.2e-08 deTHIobiotin synthase K01935; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001451710.1 KEGG: reh:H16_A3019 0.0056 hutC; histidine utilization repressor; COG: COG2186 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001451711.1 Psort location: endoplasmic reticulum, score: 9 YP_001451713.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon YP_001451714.1 COG: COG3085 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001451715.1 KEGG: eci:UTI89_C4322 4.0e-231 yifB; putative 2-component regulator K07391; COG: COG0606 Predicted ATPase with chaperone activity; Psort location: cytoplasmic, score: 23 YP_001451716.1 Psort location: cytoplasmic, score: 23 YP_001451717.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit YP_001451718.1 KEGG: sec:SC3807 4.1e-39 ilvM; acetolactate synthase II, small subunit K01653; COG: COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit; Psort location: cytoplasmic, score: 23 YP_001451719.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_001451720.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_001451721.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway YP_001451722.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate YP_001451723.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_001451724.1 KEGG: ssn:SSO_3946 2.0e-46 ppiC; peptidyl-prolyl cis-trans isomerase C K03769; COG: COG0760 Parvulin-like peptidyl-prolyl isomerase; Psort location: cytoplasmic, score: 23 YP_001451725.1 Psort location: nuclear, score: 23 YP_001451726.1 Psort location: cytoplasmic, score: 23 YP_001451727.1 KEGG: eci:UTI89_C3860 2.0e-06 crp; CRP-cAMP transcriptional dual regulator K00924; COG: NOG28604 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001451728.1 KEGG: sty:STY3644 6.3e-107 probable uridine phosphorylase K00757; COG: COG2820 Uridine phosphorylase; Psort location: cytoplasmic, score: 23 YP_001451729.1 COG: COG3201 Nicotinamide mononucleotide transporter; Psort location: plasma membrane, score: 23 YP_001451730.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication YP_001451731.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation YP_001451732.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation YP_001451733.1 KEGG: eci:UTI89_C4335 4.1e-55 trxA; THIoredoxin 1 K03671; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: cytoplasmic, score: 23 YP_001451734.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_001451735.1 KEGG: stm:STM3918 3.3e-181 rfe; undecaprenyl-phosphate N-acetylglucosaminyltransferase K02851; COG: COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase; Psort location: plasma membrane, score: 23 YP_001451736.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein YP_001451737.1 KEGG: stm:STM3920 1.9e-185 wecB; UDP-N-acetyl glucosamine -2-epimerase K01791; COG: COG0381 UDP-N-acetylglucosamine 2-epimerase; Psort location: cytoplasmic, score: 23 YP_001451738.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid YP_001451739.1 KEGG: stm:STM3922 1.5e-176 rffG; dTDP-glucose 4,6-dehydratase K01710; COG: COG1088 dTDP-D-glucose 4,6-dehydratase; Psort location: extracellular, including cell wall, score: 9 YP_001451740.1 KEGG: sfx:S3897 2.2e-152 rffH; glucose-1-phosphate thymidylyltransferase K00973; COG: COG1209 dTDP-glucose pyrophosphorylase; Psort location: cytoplasmic, score: 23 YP_001451741.1 KEGG: eci:UTI89_C4346 6.6e-96 rffC, rff, wecD, yifH; TDP-fucosamine acetyltransferase K00680; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001451742.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis YP_001451743.1 COG: COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; Psort location: plasma membrane, score: 23 YP_001451744.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis YP_001451745.1 enterobacterial common antigen polymerase YP_001451746.1 KEGG: eco:b3794 4.0e-121 wecG, rff; probable UDP-N-acetyl-D-mannosaminuronic acid transferase; synthesis of enterobacterial common antigen (ECA) K02852; COG: COG1922 Teichoic acid biosynthesis proteins; Psort location: cytoplasmic, score: 23 YP_001451747.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function YP_001451749.1 COG: COG3071 Uncharacterized enzyme of heme biosynthesis; Psort location: endoplasmic reticulum, score: 9 YP_001451750.1 KEGG: stm:STM3936 4.6e-182 hemX; uroporphyrinogen III methylase K02496; COG: COG2959 Uncharacterized enzyme of heme biosynthesis; Psort location: nuclear, score: 23 YP_001451751.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis YP_001451752.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_001451753.2 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP YP_001451754.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly YP_001451755.1 COG: COG5567 Predicted small periplasmic lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001451756.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_001451757.1 KEGG: azo:azo0595 6.1e-05 3',5'-cyclic-nucleotide phosphodiesterase K01120; COG: COG3159 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001451758.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001451759.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function YP_001451760.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. YP_001451761.1 Psort location: mitochondrial, score: 23 YP_001451762.1 responsible for the influx of magnesium ions YP_001451763.1 COG: COG2962 Predicted permeases; Psort location: plasma membrane, score: 23 YP_001451764.1 COG: COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; Psort location: cytoplasmic, score: 23 YP_001451765.1 catalyzes the hydrolysis of phosphatidylcholine YP_001451766.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway YP_001451767.1 COG: COG1280 Putative threonine efflux protein; Psort location: endoplasmic reticulum, score: 9 YP_001451768.1 Psort location: mitochondrial, score: 23 YP_001451769.1 Psort location: cytoplasmic, score: 23 YP_001451770.1 COG: COG1280 Putative threonine efflux protein; Psort location: endoplasmic reticulum, score: 9 YP_001451771.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates YP_001451772.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium YP_001451773.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001451774.1 Psort location: nuclear, score: 23 YP_001451775.1 KEGG: shn:Shewana3_3435 1.1e-11 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001451776.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_001451777.1 KEGG: stm:STM3967 3.7e-134 dlhH; putative dienelactone hydrolase family K01061; COG: COG0412 Dienelactone hydrolase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001451778.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway YP_001451779.1 Psort location: cytoplasmic, score: 23 YP_001451780.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner YP_001451781.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_001451782.1 COG: COG3165 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001451783.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions YP_001451784.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_001451785.1 mediates the export of protein precursors bearing twin-arginine signal peptides YP_001451786.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane YP_001451787.1 magnesium dependent; not involved in the Sec-independent protein export system YP_001451788.1 COG: COG0250 Transcription antiterminator; Psort location: cytoplasmic, score: 23 YP_001451789.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol YP_001451790.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin YP_001451791.1 Psort location: mitochondrial, score: 23 YP_001451792.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_001451793.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_001451794.1 KEGG: ecc:c4793 0.00031 fadB; fatty oxidation complex alpha subunit K00022:K01692:K01782:K01825; Psort location: nuclear, score: 23 YP_001451795.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters YP_001451796.1 KEGG: eci:UTI89_C4433 7.5e-95 yigZ; hypothetical protein K00560; COG: COG1739 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001451797.1 KEGG: shn:Shewana3_0031 2.9e-77 potassium uptake protein, TrkH family K00961; COG: COG0168 Trk-type K+ transport systems, membrane components; Psort location: plasma membrane, score: 23 YP_001451798.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX YP_001451799.1 KEGG: cal:orf19.2425 8.7e-05 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001451800.1 COG: COG5544 Predicted periplasmic lipoprotein; Psort location: cytoplasmic, score: 23 YP_001451801.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome YP_001451802.1 KEGG: eci:UTI89_C2907 0. yfiQ; hypothetical protein YfiQ K09181; COG: COG1042 Acyl-CoA synthetase (NDP forming); Psort location: cytoplasmic, score: 23 YP_001451803.1 COG: COG3148 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001451804.1 KEGG: ecp:ECP_2584 7.5e-72 THIoredoxin 2 K03672; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: cytoplasmic, score: 23 YP_001451805.1 KEGG: stt:t0262 1.4e-171 yfiF; putative RNA methyltransferase K03214; COG: COG0566 rRNA methylases; Psort location: cytoplasmic, score: 23 YP_001451806.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_001451807.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit YP_001451808.1 facilitates an early step in the assembly of the 50S subunit of the ribosome YP_001451809.1 KEGG: eci:UTI89_C2897 2.4e-98 yfiC; hypothetical protein YfiC K00599; COG: COG4123 Predicted O-methyltransferase; Psort location: cytoplasmic, score: 23 YP_001451810.1 catalyzes the formation of oxaloacetate from L-aspartate YP_001451811.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_001451812.1 COG: COG3073 Negative regulator of sigma E activity; Psort location: nuclear, score: 23 YP_001451813.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP YP_001451814.1 involved in the reduction of the SoxR iron-sulfur cluster YP_001451815.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001451816.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins YP_001451817.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_001451818.1 COG: COG1381 Recombinational DNA repair protein (RecF pathway); Psort location: cytoplasmic, score: 23 YP_001451819.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_001451820.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_001451821.1 KEGG: mmp:MMP1692 4.7e-06 vhuB; polyferredoxin, associated with F420-non-reducing hydrogenase; COG: COG1145 Ferredoxin; Psort location: nuclear, score: 23 YP_001451822.1 KEGG: bte:BTH_I1550 7.8e-23 glucokinase/transcriptional regulator, RpiR family, fusion K00845; COG: COG1737 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001451823.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_001451824.1 COG: COG0560 Phosphoserine phosphatase; Psort location: cytoplasmic, score: 23 YP_001451825.1 KEGG: stt:t0289 2.6e-85 yfhC; hypothetical protein K01500; COG: COG0590 Cytosine/adenosine deaminases; Psort location: cytoplasmic, score: 23 YP_001451826.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function YP_001451827.1 Psort location: nuclear, score: 23 YP_001451828.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001451829.1 Psort location: cytoplasmic, score: 23 YP_001451830.1 Psort location: nuclear, score: 23 YP_001451831.1 KEGG: ecp:ECP_2558 8.9e-227 putative sensor-like histidine kinase YfhK K07711; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001451832.1 COG: NOG06210 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001451833.1 KEGG: eci:UTI89_C2502 1.5e-82 atoC; acetoacetate metabolism regulatory protein AtoC K07714; COG: COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains; Psort location: cytoplasmic, score: 23 YP_001451834.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA YP_001451835.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine YP_001451836.1 Psort location: cytoplasmic, score: 23 YP_001451837.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001451838.1 KEGG: chy:CHY_0270 4.0e-25 glcK; glucokinase K00845; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: mitochondrial, score: 23 YP_001451839.1 KEGG: eci:UTI89_C2868 0. yphG; hypothetical protein YphG K00754; COG: NOG06209 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001451840.1 KEGG: cal:orf19.644 1.2e-46 HXT4; high-affinity glucose transporter or sensor K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001451841.1 KEGG: eco:b3879 0.0025 yihR; predicted aldose-1-epimerase K01785; COG: COG2017 Galactose mutarotase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001451842.1 Psort location: mitochondrial, score: 23 YP_001451843.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters YP_001451844.1 Psort location: mitochondrial, score: 23 YP_001451845.1 KEGG: spz:M5005_Spy_1664 0.0062 PTS system, mannitol (cryptic)-specific IIA component K00890; COG: COG3711 Transcriptional antiterminator; Psort location: mitochondrial, score: 23 YP_001451846.1 COG: COG3683 ABC-type uncharacterized transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001451847.1 COG: COG2215 ABC-type uncharacterized transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001451848.1 KEGG: stm:STM2546 4.2e-133 suhB; putative myo-inositol-1(or 4)-monophosphatase K01092; COG: COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family; Psort location: cytoplasmic, score: 23 YP_001451849.1 KEGG: stm:STM2545 6.2e-123 putative rRNA methylase K02533; COG: COG0565 rRNA methylase; Psort location: cytoplasmic, score: 23 YP_001451850.1 regulates the expression of the iscRSUA operon YP_001451851.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_001451852.1 KEGG: rxy:Rxyl_1354 5.9e-16 tRNA (5-methylaminomethyl-2-THIouridylate)-methyltransferase K00566; COG: COG0822 NifU homolog involved in Fe-S cluster formation; Psort location: cytoplasmic, score: 23 YP_001451853.1 COG: COG0316 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001451854.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins YP_001451855.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_001451856.1 KEGG: eci:UTI89_C2847 7.5e-56 fdx; ferredoxin, 2Fe-2S K04755; COG: COG0633 Ferredoxin; Psort location: cytoplasmic, score: 23 YP_001451857.1 COG: COG2975 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001451858.1 Psort location: nuclear, score: 23 YP_001451859.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide YP_001451860.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I YP_001451861.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds YP_001451862.1 COG: COG2373 Large extracellular alpha-helical protein; Psort location: extracellular, including cell wall, score: 9 YP_001451863.1 Psort location: mitochondrial, score: 23 YP_001451864.1 penicillin-insensitive transglycosylase/transpeptidase YP_001451865.1 Psort location: cytoplasmic, score: 23 YP_001451866.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_001451867.1 Psort location: cytoplasmic, score: 23 YP_001451868.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_001451869.1 KEGG: lsl:LSL_1517 4.1e-05 glucosyltransferase-S K00689; COG: COG1426 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001451870.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_001451871.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001451872.1 COG: COG2976 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001451873.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis YP_001451874.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001451875.1 COG: COG3104 Dipeptide/tripeptide permease; Psort location: plasma membrane, score: 23 YP_001451876.1 KEGG: aha:AHA_1764 2.7e-12 ubiquitin ligase sinat5 K01932; COG: NOG17950 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001451877.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_001451878.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_001451879.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001451880.1 COG: NOG23217 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001451881.1 COG: NOG36091 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001451882.1 COG: NOG13900 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001451883.1 Psort location: nuclear, score: 23 YP_001451884.1 KEGG: shn:Shewana3_3829 2.4e-26 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) K01745; COG: COG2199 FOG: GGDEF domain; Psort location: plasma membrane, score: 23 YP_001451885.1 KEGG: sty:STY2743 3.3e-259 ppx; exopolyphosphatase K01514; COG: COG0248 Exopolyphosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001451886.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_001451887.1 Psort location: mitochondrial, score: 23 YP_001451888.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_001451889.1 KEGG: sbo:SBO_2520 8.2e-137 purM; phosphoribosylaminoimidazole synthetase K01933; COG: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; Psort location: cytoplasmic, score: 23 YP_001451890.1 Psort location: mitochondrial, score: 23 YP_001451891.1 converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism YP_001451892.1 KEGG: sec:SC2495 2.6e-101 upp; uracil phosphoribosyltransferase K00761; COG: COG0035 Uracil phosphoribosyltransferase; Psort location: cytoplasmic, score: 23 YP_001451893.1 KEGG: bcz:BCZK0244 2.2e-07 guanine-hypoxanTHIne permease; xanTHIne/uracil permease family protein K06901; COG: COG2233 XanTHIne/uracil permeases; Psort location: plasma membrane, score: 23 YP_001451894.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP YP_001451895.1 KEGG: pfo:Pfl_0989 6.7e-71 peptidase M17, leucyl aminopeptidase-like K01255; COG: COG0260 Leucyl aminopeptidase; Psort location: cytoplasmic, score: 23 YP_001451896.1 KEGG: lsa:LSA1693 1.0e-81 asnA2; L-asparaginase K01424; COG: COG1446 Asparaginase; Psort location: cytoplasmic, score: 23 YP_001451897.1 KEGG: bli:BL03842 1.3e-44 licC; phosphotransferase system (PTS) lichenan-specific enzyme IIC component K02761; COG: COG1455 Phosphotransferase system cellobiose-specific component IIC; Psort location: endoplasmic reticulum, score: 9 YP_001451898.1 KEGG: bca:BCE_5325 6.6e-48 celB; PTS system, cellobiose-specific IIC component K02761; COG: COG1455 Phosphotransferase system cellobiose-specific component IIC; Psort location: endoplasmic reticulum, score: 9 YP_001451899.1 KEGG: nwi:Nwi_1293 6.1e-13 integrase, catalytic region K00986; COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001451900.1 KEGG: pha:PSHAa1133 2.2e-33 arsenate reductase; COG: COG1393 Arsenate reductase and related proteins, glutaredoxin family; Psort location: nuclear, score: 23 YP_001451901.1 KEGG: eci:UTI89_C2810 1.3e-241 yfgC; hypothetical protein YfgC precursor; COG: COG4783 Putative Zn-dependent protease, contains TPR repeats; Psort location: nuclear, score: 23 YP_001451902.1 KEGG: tbd:Tbd_2668 4.2e-28 phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthetase K01923; COG: COG0628 Predicted permease; Psort location: plasma membrane, score: 23 YP_001451903.1 COG: COG3314 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001451904.1 COG: COG0700 Uncharacterized membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001451905.1 KEGG: ecc:c5408 6.6e-135 iadA; isoaspartyl dipeptidase K01305; COG: NOG06797 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001451906.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine YP_001451907.1 KEGG: eci:UTI89_C2806 3.8e-68 gcvR; glycine cleavage system transcriptional repressor K03567; COG: COG2716 Glycine cleavage system regulatory protein; Psort location: cytoplasmic, score: 23 YP_001451908.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001451909.1 COG: COG3317 Uncharacterized lipoprotein; Psort location: golgi, score: 9 YP_001451910.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001451911.1 KEGG: eci:UTI89_C2802 3.5e-136 ypfJ; hypothetical protein; COG: COG2321 Predicted metalloprotease; Psort location: endoplasmic reticulum, score: 9 YP_001451912.1 COG: COG1444 Predicted P-loop ATPase fused to an acetyltransferase; Psort location: cytoplasmic, score: 23 YP_001451913.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate YP_001451914.1 COG: NOG13899 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001451915.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_001451916.1 KEGG: eci:UTI89_C2797 5.6e-51 yffB; conserved THIoredoxin-like protein; COG: COG1393 Arsenate reductase and related proteins, glutaredoxin family; Psort location: cytoplasmic, score: 23 YP_001451917.1 Psort location: mitochondrial, score: 23 YP_001451918.1 KEGG: eci:UTI89_C2351 2.5e-112 yegO; hypothetical protein YegO K07789; COG: COG0841 Cation/multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001451919.1 Psort location: cytoplasmic, score: 23 YP_001451920.1 KEGG: stt:t0379 4.2e-268 narQ; nitrate/nitrite sensor protein K07674; COG: COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific; Psort location: endoplasmic reticulum, score: 9 YP_001451921.1 Psort location: cytoplasmic, score: 23 YP_001451922.1 Psort location: cytoplasmic, score: 23 YP_001451923.1 Psort location: mitochondrial, score: 23 YP_001451924.1 KEGG: eci:UTI89_C2794 1.1e-226 aegA, yffG; putative oxidoreductase Fe-S subunit K00264; COG: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001451925.1 KEGG: eci:UTI89_C2793 8.3e-89 yffH; hypothetical protein YffH K01515; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001451926.1 COG: NOG10065 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001451927.1 Psort location: mitochondrial, score: 23 YP_001451928.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001451929.1 KEGG: sty:STY2710 1.6e-154 talA; transaldolase A K00616; COG: COG0176 Transaldolase; Psort location: cytoplasmic, score: 23 YP_001451930.1 Psort location: mitochondrial, score: 23 YP_001451931.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_001451932.1 KEGG: lwe:lwe0363 0.0046 PTS system; fructose-specific IIB component K00890; COG: COG4810 Ethanolamine utilization protein; Psort location: cytoplasmic, score: 23 YP_001451933.1 KEGG: eci:UTI89_C2785 5.8e-72 eutP; ethanolamine utilization protein EutP K04029; COG: COG4917 Ethanolamine utilization protein; Psort location: cytoplasmic, score: 23 YP_001451934.1 COG: COG4766 Ethanolamine utilization protein; Psort location: cytoplasmic, score: 23 YP_001451935.1 KEGG: stm:STM2467 2.8e-127 eutT; putative cobalamin adenosyltransferase, ethanolamine utilization K04032; COG: COG4812 Ethanolamine utilization cobalamin adenosyltransferase; Psort location: cytoplasmic, score: 23 YP_001451936.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta YP_001451937.1 COG: COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: cytoplasmic, score: 23 YP_001451938.1 COG: COG4576 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: cytoplasmic, score: 23 YP_001451939.1 KEGG: rru:Rru_A0914 9.8e-102 aldehyde dehydrogenase K04021; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001451940.1 COG: COG4820 Ethanolamine utilization protein, possible chaperonin; Psort location: cytoplasmic, score: 23 YP_001451941.1 KEGG: eci:UTI89_C2777 1.7e-182 eutG, yffV; ethanolamine utilization protein EutG iron-containing alcohol dehydrogenase K04022; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: cytoplasmic, score: 23 YP_001451942.1 KEGG: rsp:RSP_1788 0.00081 fruA; PTS system, fructose-specificIIBC component K02769:K02770; COG: COG3192 Ethanolamine utilization protein; Psort location: plasma membrane, score: 23 YP_001451943.1 ethanolamine utilization protein EutA YP_001451944.1 KEGG: spt:SPA0410 3.9e-240 eutB; ethanolamine ammonia-lyase heavy chain K03735; COG: COG4303 Ethanolamine ammonia-lyase, large subunit; Psort location: cytoplasmic, score: 23 YP_001451945.1 catalyzes the formation of acetaldehyde from ethanolamine YP_001451946.1 COG: COG4816 Ethanolamine utilization protein; Psort location: cytoplasmic, score: 23 YP_001451947.1 COG: COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: cytoplasmic, score: 23 YP_001451948.1 activates the transcription of the ethanolamine utilization operon YP_001451949.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_001451950.1 KEGG: eci:UTI89_C2768 1.4e-141 amiA; probable N-acetylmuramoyl-L-alanine amidase AmiA precursor K01448; COG: COG0860 N-acetylmuramoyl-L-alanine amidase; Psort location: cytoplasmic, score: 23 YP_001451951.1 Psort location: mitochondrial, score: 23 YP_001451952.1 KEGG: eci:UTI89_C2767 5.2e-71 ypeA; hypothetical protein YpeA K00680; COG: COG0456 Acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001451953.1 COG: NOG08687 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001451954.1 COG: NOG06776 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001451955.1 KEGG: reh:H16_B0946 1.5e-43 predicted iron-dependent peroxidase K00430; COG: COG2837 Predicted iron-dependent peroxidase; Psort location: cytoplasmic, score: 23 YP_001451956.1 KEGG: oih:OB0667 4.4e-51 beta-lactamase K01467; COG: COG1680 Beta-lactamase class C and other penicillin binding proteins; Psort location: extracellular, including cell wall, score: 9 YP_001451957.1 belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component YP_001451958.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_001451959.1 KEGG: cbu:CBU_1296 0.0063 NAD+ kinase K00858; Psort location: extracellular, including cell wall, score: 9 YP_001451960.1 Psort location: cytoplasmic, score: 23 YP_001451961.1 COG: COG3203 Outer membrane protein (porin); Psort location: extracellular, including cell wall, score: 9 YP_001451962.1 KEGG: bma:BMA2132 1.8e-23 glucokinase/transcriptional regulator, RpiR family, fusion K00845; COG: COG1737 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001451963.1 KEGG: stm:STM2445 4.5e-129 ucpA; putative oxidoreductase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001451964.1 COG: COG4150 ABC-type sulfate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001451965.1 KEGG: syn:sll0739 1.2e-28 modBC; ABC-type molybdate transport system permease/ATP-binding protein K02018; COG: COG0555 ABC-type sulfate transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001451966.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import YP_001451967.1 KEGG: sdy:SDY_2618 7.7e-189 cysA; ATP-binding component of sulfate permease A protein K02045; COG: COG1118 ABC-type sulfate/molybdate transport systems, ATPase component; Psort location: cytoplasmic, score: 23 YP_001451968.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide YP_001451969.1 Catalyzes the transfer of the ammonia group from glutamine to a new carbon-nitrogen group YP_001451970.1 KEGG: nwi:Nwi_0881 1.1e-26 transcriptional regulatory protein GntR family K00825; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: nuclear, score: 23 YP_001451971.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_001451972.1 COG: NOG31214 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001451973.1 Psort location: nuclear, score: 23 YP_001451974.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose YP_001451975.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system YP_001451976.1 KEGG: bci:BCI_0069 7.4e-33 ptsH; phosphocarrier protein HPr K00890; COG: COG1925 Phosphotransferase system, HPr-related proteins; Psort location: cytoplasmic, score: 23 YP_001451977.1 Psort location: mitochondrial, score: 23 YP_001451978.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis YP_001451979.1 putative role in sulfur assimilation YP_001451980.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure YP_001451981.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_001451982.1 KEGG: cmu:TC0823 9.2e-05 DNA polymerase III, epsilon subunit, putative K02342; COG: COG3530 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001451983.1 COG: COG0385 Predicted Na+-dependent transporter; Psort location: plasma membrane, score: 23 YP_001451984.1 Psort location: nuclear, score: 23 YP_001451985.1 KEGG: shn:Shewana3_3435 2.4e-20 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: mitochondrial, score: 23 YP_001451986.1 KEGG: ddi:DDB0231210 6.3e-05 putative CDC7 family protein kinase K02214; COG: NOG12169 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001451987.1 Psort location: endoplasmic reticulum, score: 9 YP_001451988.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation YP_001451989.1 KEGG: eci:UTI89_C3355 9.0e-131 nupG; transport of nucleosides, permease protein K03289; COG: NOG06211 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001451990.1 KEGG: shn:Shewana3_3435 1.1e-17 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: mitochondrial, score: 23 YP_001451991.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001451992.1 COG: NOG09785 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001451993.1 COG: NOG09771 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001451994.1 KEGG: vfi:VF0087 2.6e-23 sensory transduction protein kinase; COG: COG2199 FOG: GGDEF domain; Psort location: plasma membrane, score: 23 YP_001451995.1 COG: COG1972 Nucleoside permease; Psort location: plasma membrane, score: 23 YP_001451996.1 Psort location: endoplasmic reticulum, score: 9 YP_001451997.1 COG: COG1914 Mn2+ and Fe2+ transporters of the NRAMP family; Psort location: plasma membrane, score: 23 YP_001451998.1 KEGG: tpv:TP01_0149 0.0024 serine/threonine protein kinase K08287; COG: NOG09770 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001451999.1 Psort location: cytoplasmic, score: 23 YP_001452000.1 KEGG: ret:RHE_CH02454 8.9e-108 probable oxidoreductase protein K05882; COG: COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001452001.1 Psort location: nuclear, score: 23 YP_001452002.1 KEGG: stm:STM2405 6.4e-240 indolepyruvate decarboxylase K01568; COG: COG3961 Pyruvate decarboxylase and related THIamine pyrophosphate-requiring enzymes; Psort location: cytoplasmic, score: 23 YP_001452003.1 KEGG: cpr:CPR_1400 4.3e-09 chloride channel protein K01529; COG: COG0038 Chloride channel protein EriC; Psort location: plasma membrane, score: 23 YP_001452004.1 Psort location: nuclear, score: 23 YP_001452005.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate YP_001452006.1 KEGG: ecc:c2926 3.9e-50 putative PTS system IIB component ypdH K02769; COG: COG1445 Phosphotransferase system fructose-specific component IIB; Psort location: cytoplasmic, score: 23 YP_001452007.1 KEGG: ecc:c2925 2.2e-207 putative PTS system IIC component ypdG K02770; COG: COG1299 Phosphotransferase system, fructose-specific IIC component; Psort location: plasma membrane, score: 23 YP_001452008.1 Xaa-Pro aminopeptidase; limited methionine aminopeptidase YP_001452009.1 metalloprotein YP_001452010.1 KEGG: sfx:S2588 0. putative PTS system enzyme IIA component, enzyme I K02766:K02768; COG: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); Psort location: cytoplasmic, score: 23 YP_001452011.1 KEGG: bli:BL05281 1.6e-08 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001452012.1 KEGG: rru:Rru_A0376 1.2e-18 transcriptional regulator, LytR/AlgR family K07705; COG: COG3279 Response regulator of the LytR/AlgR family; Psort location: cytoplasmic, score: 23 YP_001452013.1 KEGG: ece:Z3645 5.3e-284 putative sensor protein K07704; COG: COG3275 Putative regulator of cell autolysis; Psort location: plasma membrane, score: 23 YP_001452014.1 KEGG: eco:b2379 2.5e-215 yfdZ; putative PLP-dependent aminotransferase; COG: COG0436 Aspartate/tyrosine/aromatic aminotransferase; Psort location: cytoplasmic, score: 23 YP_001452015.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock YP_001452016.1 Psort location: nuclear, score: 23 YP_001452017.1 Psort location: cytoplasmic, score: 23 YP_001452018.1 Psort location: cytoplasmic, score: 23 YP_001452019.1 KEGG: bme:BMEII0148 2.6e-74 extracellular serine protease; COG: COG3468 Type V secretory pathway, adhesin AidA; Psort location: nuclear, score: 23 YP_001452020.1 Psort location: cytoplasmic, score: 23 YP_001452021.1 KEGG: vfi:VF0494 7.5e-10 sensory transduction protein kinase; COG: COG2200 FOG: EAL domain; Psort location: endoplasmic reticulum, score: 9 YP_001452022.1 COG: COG2259 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001452023.1 KEGG: hma:rrnAC3411 1.3e-12 metal dependent amidohydrolase superfamily protein K01443:K01427:K01465:K01486; COG: COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold; Psort location: cytoplasmic, score: 23 YP_001452024.1 COG: COG4317 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001452025.1 KEGG: reh:H16_B0343 2.4e-89 hydrolase K01463; COG: COG1335 Amidases related to nicotinamidase; Psort location: cytoplasmic, score: 23 YP_001452026.1 Psort location: cytoplasmic, score: 23 YP_001452027.1 KEGG: shn:Shewana3_3435 3.5e-11 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001452028.1 KEGG: eci:UTI89_C1638 1.5e-137 glyceraldehyde 3-phosphate dehydrogenase A K00134; COG: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001452029.1 Psort location: cytoplasmic, score: 23 YP_001452030.1 heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate YP_001452031.1 KEGG: syn:sll1687 1.4e-24 hik17; hypothetical protein; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 23 YP_001452032.1 KEGG: syn:slr1608 2.4e-36 gdhB; putative glucose dehydrogenase-B, periplasmic protein K00117; COG: COG2133 Glucose/sorbosone dehydrogenases; Psort location: extracellular, including cell wall, score: 9 YP_001452033.1 Psort location: nuclear, score: 23 YP_001452034.1 KEGG: ace:Acel_1971 3.6e-14 dTMP kinase K00943; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 23 YP_001452035.1 KEGG: psp:PSPPH_4690 4.6e-10 formate transporter K00122; COG: COG2116 Formate/nitrite family of transporters; Psort location: endoplasmic reticulum, score: 9 YP_001452036.1 Psort location: nuclear, score: 23 YP_001452037.1 COG: COG2853 Surface lipoprotein; Psort location: cytoplasmic, score: 23 YP_001452038.1 COG: COG2067 Long-chain fatty acid transport protein; Psort location: extracellular, including cell wall, score: 9 YP_001452039.1 COG: COG3691 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001452040.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth YP_001452041.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate YP_001452042.1 Psort location: cytoplasmic, score: 23 YP_001452043.1 KEGG: spt:SPA0477 3.3e-78 sixA; phosphohistidine phosphatase K08296; COG: COG2062 Phosphohistidine phosphatase SixA; Psort location: endoplasmic reticulum, score: 9 YP_001452044.1 Psort location: nuclear, score: 23 YP_001452045.1 Psort location: nuclear, score: 23 YP_001452046.1 COG: COG2840 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001452047.1 involved in methylation of ribosomal protein L3 YP_001452048.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_001452049.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm YP_001452050.1 COG: COG0730 Predicted permeases; Psort location: endoplasmic reticulum, score: 9 YP_001452051.1 COG: COG3101 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001452052.1 COG: NOG13546 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452053.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules YP_001452054.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001452055.1 COG: NOG26784 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001452056.1 KEGG: eci:UTI89_C5041 8.8e-07 yjiJ; hypothetical protein YjiJ K00403; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001452057.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein YP_001452058.1 KEGG: sec:SC2372 2.2e-184 pdxB; erythronate-4-phosphate dehyrogenase K03473; COG: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001452059.1 KEGG: eci:UTI89_C2604 2.8e-159 usg; USG-1 protein K00133; COG: COG0136 Aspartate-semialdehyde dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001452060.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001452061.1 KEGG: lsl:LSL_1322 1.6e-14 alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: endoplasmic reticulum, score: 9 YP_001452062.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_001452063.1 KEGG: sty:STY2596 2.1e-202 folC; folylpolyglutamate synthase K01927:K01930; COG: COG0285 Folylpolyglutamate synthase; Psort location: cytoplasmic, score: 23 YP_001452064.1 KEGG: pfo:Pfl_1900 7.6e-15 argininosuccinate synthase K03749; COG: COG3147 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001452065.1 membrane protein required for colicin V production YP_001452066.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_001452067.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate YP_001452068.1 Psort location: cytoplasmic, score: 23 YP_001452069.1 KEGG: bur:Bcep18194_A4695 7.1e-28 ABC polar amino acid transporter, periplasmic ligand binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001452070.1 KEGG: bur:Bcep18194_A4695 3.7e-31 ABC polar amino acid transporter, periplasmic ligand binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001452071.1 KEGG: eca:ECA0855 4.8e-22 ABC transporter permease protein K02028; COG: COG4215 ABC-type arginine transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001452072.1 KEGG: sma:SAV6546 2.8e-24 putative ABC transporter permease K02028; COG: COG4160 ABC-type arginine/histidine transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001452073.1 KEGG: sfl:SF2382 1.5e-128 hisP; ATP-binding component of histidine transport K02028; COG: COG4598 ABC-type histidine transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001452074.1 KEGG: bca:BCE_1955 1.8e-13 acetyltransferase, GNAT family K00676; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001452075.1 KEGG: ava:Ava_0206 8.6e-55 hypothetical protein; COG: COG1090 Predicted nucleoside-diphosphate sugar epimerase; Psort location: cytoplasmic, score: 23 YP_001452076.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate YP_001452077.1 KEGG: eci:UTI89_C2585 1.9e-89 yfcF; hypothetical protein K00799; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001452078.1 KEGG: eci:UTI89_C2584 3.9e-82 yfcE; hypothetical protein; COG: COG0622 Predicted phosphoesterase; Psort location: cytoplasmic, score: 23 YP_001452079.1 KEGG: ssn:SSO_2356 8.5e-87 putative regulator; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001452080.1 KEGG: efa:EF1922 1.4e-06 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: mitochondrial, score: 23 YP_001452081.1 KEGG: sty:STY2574 4.4e-58 putative sugar phosphotransferase component II A K02821; COG: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); Psort location: cytoplasmic, score: 23 YP_001452082.1 KEGG: spt:SPA0521 9.6e-40 putative sugar phosphotransferase component II B K02822; COG: COG3414 Phosphotransferase system, galactitol-specific IIB component; Psort location: cytoplasmic, score: 23 YP_001452083.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_001452084.1 KEGG: sec:SC2342 5.8e-136 tktN; putative transketolase K00615; COG: COG3959 Transketolase, N-terminal subunit; Psort location: cytoplasmic, score: 23 YP_001452085.1 KEGG: stm:STM2340 7.1e-154 putative transketolase K00615; COG: COG3958 Transketolase, C-terminal subunit; Psort location: cytoplasmic, score: 23 YP_001452086.1 Psort location: nuclear, score: 23 YP_001452087.1 COG: COG1288 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001452088.1 Psort location: mitochondrial, score: 23 YP_001452089.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_001452090.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_001452091.1 Psort location: cytoplasmic, score: 23 YP_001452092.1 COG: COG3092 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001452093.1 COG: COG3013 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001452094.1 KEGG: eci:UTI89_C2575 2.6e-94 yfbT; protein YfbT K01112; COG: COG0637 Predicted phosphatase/phosphohexomutase; Psort location: cytoplasmic, score: 23 YP_001452095.1 COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001452096.1 KEGG: sdy:SDY_2487 1.3e-97 putative alpha helix protein K08722; COG: COG1896 Predicted hydrolases of HD superfamily; Psort location: mitochondrial, score: 23 YP_001452097.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_001452098.1 Psort location: cytoplasmic, score: 23 YP_001452099.1 KEGG: shn:Shewana3_3435 0.00027 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001452100.1 Catalyzes the transfer of electrons from NADH to quinone YP_001452101.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_001452102.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms YP_001452103.1 Catalyzes the transfer of electrons from NADH to quinone YP_001452104.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase YP_001452105.1 Catalyzes the transfer of electrons from NADH to quinone YP_001452106.1 Catalyzes the transfer of electrons from NADH to quinone YP_001452107.1 Catalyzes the transfer of electrons from NADH to quinone YP_001452108.1 Catalyzes the transfer of electrons from NADH to quinone YP_001452109.1 Catalyzes the transfer of electrons from NADH to quinone YP_001452110.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_001452111.1 Catalyzes the transfer of electrons from NADH to quinone YP_001452112.1 Catalyzes the transfer of electrons from NADH to quinone YP_001452113.1 KEGG: stm:STM2314 1.5e-162 putative chemotaxis signal transduction protein K03415; COG: COG0784 FOG: CheY-like receiver; Psort location: cytoplasmic, score: 23 YP_001452114.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions YP_001452115.1 KEGG: vfi:VF0317 8.5e-32 acetyltransferase K02348; COG: COG2153 Predicted acyltransferase; Psort location: cytoplasmic, score: 23 YP_001452116.1 COG: COG4575 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001452117.1 KEGG: sec:SC2310 3.3e-188 menF; isochorismate synthase (isochorismate hydroxymutase 2), menaquinone biosynthesis K02552; COG: COG1169 Isochorismate synthase; Psort location: cytoplasmic, score: 23 YP_001452118.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis YP_001452119.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA YP_001452120.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_001452121.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate YP_001452122.1 KEGG: spt:SPA0558 4.1e-206 menE; O-succinylbenzoic acid-CoA ligase K01911; COG: COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; Psort location: cytoplasmic, score: 23 YP_001452123.1 KEGG: ypk:y2981 5.4e-227 katE; catalase; hydroperoxidase HPII(III) K03781; COG: COG0753 Catalase; Psort location: cytoplasmic, score: 23 YP_001452124.1 COG: NOG08732 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001452125.1 KEGG: mmu:319945 0.00037 Flad1; RFad1, flavin adenine dinucleotide synthetase, homolog (yeast) K00953; COG: COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; Psort location: cytoplasmic, score: 23 YP_001452126.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate YP_001452127.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters YP_001452128.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor YP_001452129.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell YP_001452130.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic YP_001452131.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases YP_001452132.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA YP_001452133.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001452134.1 Involved in ubiquinone biosynthesis YP_001452135.1 negatively supercoils closed circular double-stranded DNA YP_001452136.1 KEGG: eci:UTI89_C2506 4.2e-181 atoB; acetyl-CoA acetyltransferase K00626; COG: COG0183 Acetyl-CoA acetyltransferase; Psort location: cytoplasmic, score: 23 YP_001452137.1 Psort location: cytoplasmic, score: 23 YP_001452138.1 COG: COG2031 Short chain fatty acids transporter; Psort location: endoplasmic reticulum, score: 9 YP_001452139.1 KEGG: eci:UTI89_C2504 1.0e-106 atoA; acetate CoA-transferase beta subunit K01035; COG: COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit; Psort location: cytoplasmic, score: 23 YP_001452140.1 KEGG: eco:b2221 1.1e-102 atoD; acetyl-CoA:acetoacetyl-CoA transferase alpha subunit K01034; COG: COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit; Psort location: cytoplasmic, score: 23 YP_001452141.1 with AtoS is a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism YP_001452142.1 with AtoC is a member of a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism YP_001452143.1 Psort location: mitochondrial, score: 23 YP_001452144.1 KEGG: sec:SC2274 0. rcsC; sensory histidine kinase in two-component regulatory system with RcsB, regulates colanic capsule biosynthesis K07677; COG: COG0784 FOG: CheY-like receiver; Psort location: endoplasmic reticulum, score: 9 YP_001452145.1 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF YP_001452146.1 KEGG: stm:STM2269 0. yojN; putative sensor/kinase in regulatory system K07676; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001452147.1 Psort location: mitochondrial, score: 23 YP_001452148.1 Psort location: nuclear, score: 23 YP_001452149.1 allows for ions and hydrophilic solutes to cross the outer membrane YP_001452150.1 Psort location: nuclear, score: 23 YP_001452151.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway YP_001452152.1 KEGG: sfx:S2427 1.7e-159 ada; O6-methylguanine-DNA methyltransferase; transcription activator/repressor K00567; COG: COG0350 Methylated DNA-protein cysteine methyltransferase; Psort location: vesicles of secretory system, score: 9 YP_001452153.1 COG: COG3145 Alkylated DNA repair protein; Psort location: cytoplasmic, score: 23 YP_001452154.1 efflux pump for the antibacterial peptide microcin J25 YP_001452155.1 KEGG: pmt:PMT0126 2.9e-47 MgtE family, putative magnesium transport protein K06213; COG: COG2239 Mg/Co/Ni transporter MgtE (contains CBS domain); Psort location: plasma membrane, score: 23 YP_001452156.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_001452157.1 serine protease inhibitor, inhibits trypsin and other proteases YP_001452158.1 Psort location: cytoplasmic, score: 23 YP_001452159.1 KEGG: eci:UTI89_C2485 1.2e-32 napD; NapD protein, subunit of nitrate reductase, periplasmic K02570; COG: COG3062 Uncharacterized protein involved in formation of periplasmic nitrate reductase; Psort location: cytoplasmic, score: 23 YP_001452160.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC YP_001452161.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway YP_001452162.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA YP_001452163.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA YP_001452164.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone YP_001452165.1 Psort location: vesicles of secretory system, score: 23 YP_001452166.1 ATP-binding protein; required for proper cytochrome c maturation YP_001452167.1 COG: COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001452168.1 KEGG: vfi:VF1822 3.4e-83 heme chaperone heme-lyase K02195; COG: COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001452169.1 COG: COG3114 Heme exporter protein D; Psort location: cytoplasmic, score: 23 YP_001452170.1 Psort location: cytoplasmic, score: 23 YP_001452171.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_001452172.1 KEGG: vfi:VF1819 8.0e-226 heme chaperone--apocytochrome heme-lyase K02198; COG: COG1138 Cytochrome c biogenesis factor; Psort location: plasma membrane, score: 23 YP_001452173.1 KEGG: azo:azo3929 3.3e-30 ccmG; protein disulfide-isomerase K01829; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: extracellular, including cell wall, score: 9 YP_001452174.1 KEGG: stm:STM4281 3.7e-18 nrfE; putative methylase K04016; COG: COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes; Psort location: endoplasmic reticulum, score: 9 YP_001452175.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes YP_001452176.1 KEGG: aha:AHA_1664 1.1e-102 putative sulfatase; COG: COG3083 Predicted hydrolase of alkaline phosphatase superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001452177.1 COG: COG3082 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001452178.1 COG: COG3081 Nucleoid-associated protein; Psort location: cytoplasmic, score: 23 YP_001452179.1 Psort location: cytoplasmic, score: 23 YP_001452180.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_001452181.1 Psort location: cytoplasmic, score: 23 YP_001452182.1 KEGG: eci:UTI89_C2461 0. yejH; hypothetical protein YejH K01529; COG: COG1061 DNA or RNA helicases of superfamily II; Psort location: cytoplasmic, score: 23 YP_001452183.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA YP_001452184.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance YP_001452185.1 Psort location: cytoplasmic, score: 23 YP_001452186.1 Psort location: cytoplasmic, score: 23 YP_001452187.1 COG: NOG14216 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001452188.1 KEGG: pen:PSEEN3568 3.3e-156 ABC transporter, ATP-binding protein; COG: COG4172 ABC-type uncharacterized transport system, duplicated ATPase component; Psort location: cytoplasmic, score: 23 YP_001452189.1 KEGG: syf:Synpcc7942_2454 1.8e-05 adenine phosphoribosyltransferase K00759; COG: COG4239 ABC-type uncharacterized transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001452190.1 KEGG: syf:Synpcc7942_2454 4.4e-35 adenine phosphoribosyltransferase K00759; COG: COG4174 ABC-type uncharacterized transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001452191.1 KEGG: shn:Shewana3_2650 0.00016 acetate kinase K00925; COG: COG4166 ABC-type oligopeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001452192.1 KEGG: vfi:VF0494 5.9e-30 sensory transduction protein kinase; COG: COG2200 FOG: EAL domain; Psort location: endoplasmic reticulum, score: 9 YP_001452193.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance YP_001452194.1 Psort location: nuclear, score: 23 YP_001452195.1 Psort location: nuclear, score: 23 YP_001452196.1 KEGG: eci:UTI89_C2451 7.9e-100 hypothetical protein K01094; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: endoplasmic reticulum, score: 23 YP_001452197.1 KEGG: reh:H16_A3373 5.1e-17 putative GTPase (G3E family); COG: COG0523 Putative GTPases (G3E family); Psort location: cytoplasmic, score: 23 YP_001452198.1 KEGG: ecc:c2709 3.7e-221 yeiQ; hypothetical oxidoreductase YeiQ; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001452199.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_001452200.1 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein YP_001452201.1 COG: COG0727 Predicted Fe-S-cluster oxidoreductase; Psort location: nuclear, score: 23 YP_001452202.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001452203.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr YP_001452204.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers YP_001452205.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001452206.1 KEGG: eci:UTI89_C2435 4.4e-58 yeiI; hypothetical sugar kinase YeiI K00852; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001452207.1 COG: COG2313 Uncharacterized enzyme involved in pigment biosynthesis; Psort location: endoplasmic reticulum, score: 9 YP_001452208.1 Psort location: nuclear, score: 23 YP_001452209.1 COG: COG1972 Nucleoside permease; Psort location: plasma membrane, score: 23 YP_001452210.1 Psort location: nuclear, score: 23 YP_001452211.1 Psort location: nuclear, score: 23 YP_001452212.1 Psort location: cytoplasmic, score: 23 YP_001452213.1 Psort location: cytoplasmic, score: 23 YP_001452214.1 KEGG: eci:UTI89_C2435 5.2e-167 yeiI; hypothetical sugar kinase YeiI K00852; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001452215.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues YP_001452216.1 COG: COG2855 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001452217.1 KEGG: shn:Shewana3_3435 1.3e-07 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001452218.1 Psort location: cytoplasmic, score: 23 YP_001452219.1 KEGG: eci:UTI89_C0120 8.8e-69 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0833 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001452220.1 YiuR; outer membrane siderophore receptor YP_001452221.1 KEGG: shn:Shewana3_1692 0.0058 Xaa-His dipeptidase K01270; COG: COG2271 Sugar phosphate permease; Psort location: plasma membrane, score: 23 YP_001452222.1 KEGG: aba:Acid345_2803 2.1e-44 phosphoserine phosphatase SerB K01079; COG: COG0560 Phosphoserine phosphatase; Psort location: cytoplasmic, score: 23 YP_001452223.1 Psort location: cytoplasmic, score: 23 YP_001452224.1 KEGG: stm:STM2196 1.0e-184 L-serine dehydratase K01752; COG: COG1760 L-serine deaminase; Psort location: cytoplasmic, score: 23 YP_001452225.1 COG: COG1396 Predicted transcriptional regulators; Psort location: nuclear, score: 23 YP_001452226.1 KEGG: eci:UTI89_C2428 2.6e-140 yeiG; hypothetical protein YeiG K03929; COG: COG0627 Predicted esterase; Psort location: cytoplasmic, score: 23 YP_001452227.1 COG: NOG08102 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001452228.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_001452229.1 COG: COG2311 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001452230.1 negative regulator of the mglBAC operon for galactose utilization YP_001452231.1 KEGG: msm:MSMEG_3095 2.9e-14 D-ribose-binding periplasmic protein; COG: COG1879 ABC-type sugar transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001452232.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains YP_001452233.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex YP_001452234.1 COG: NOG13896 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001452235.1 COG: COG2949 Uncharacterized membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001452236.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_001452237.1 KEGG: bcz:BCZK3376 1.6e-30 murein hydrolase export regulator K01238; COG: COG1346 Putative effector of murein hydrolase; Psort location: endoplasmic reticulum, score: 9 YP_001452238.1 KEGG: btk:BT9727_3424 1.9e-11 murein hydrolase exporter K06518; COG: COG1380 Putative effector of murein hydrolase LrgA; Psort location: endoplasmic reticulum, score: 9 YP_001452239.1 KEGG: shn:Shewana3_3435 3.4e-12 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001452240.1 KEGG: cal:orf19.4384 8.9e-09 HXT10; fructose symporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001452241.1 KEGG: stt:t0677 3.7e-180 putative gentisate 1,2-dioxygenase K00450; COG: COG3435 Gentisate 1,2-dioxygenase; Psort location: cytoplasmic, score: 23 YP_001452242.1 KEGG: reh:H16_B0874 3.0e-91 fumarylpyruvate hydrolase K01557; COG: COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway); Psort location: cytoplasmic, score: 23 YP_001452243.1 KEGG: pen:PSEEN2595 5.8e-65 mhbI; maleylpyruvate isomerase K01800; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoskeletal, score: 9 YP_001452244.1 catalyzes the formation of catechol from salicylate YP_001452245.1 KEGG: ecc:c2672 3.7e-157 yohI; tRNA-dihydrouridine synthase K05541; COG: COG0042 tRNA-dihydrouridine synthase; Psort location: cytoplasmic, score: 23 YP_001452246.1 Psort location: cytoplasmic, score: 23 YP_001452247.1 may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride YP_001452248.1 KEGG: lsl:LSL_1322 0.00055 alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: endoplasmic reticulum, score: 9 YP_001452249.1 COG: NOG06773 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001452250.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7 YP_001452251.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent YP_001452252.1 KEGG: ecp:ECP_2171 0. periplasmic beta-glucosidase precursor K05349; COG: COG1472 Beta-glucosidase-related glycosidases; Psort location: mitochondrial, score: 23 YP_001452253.1 KEGG: lwe:lwe1439 2.2e-27 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein); Psort location: extracellular, including cell wall, score: 9 YP_001452254.1 KEGG: lwe:lwe1439 2.1e-35 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1174 ABC-type proline/glycine betaine transport systems, permease component; Psort location: plasma membrane, score: 23 YP_001452255.1 KEGG: bur:Bcep18194_B0497 1.0e-67 ABC proline/glycine betaine transporter, ATPase subunit K05847; COG: COG1125 ABC-type proline/glycine betaine transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001452256.1 KEGG: lwe:lwe1439 1.0e-33 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1174 ABC-type proline/glycine betaine transport systems, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001452257.1 KEGG: eci:UTI89_C3737 1.1e-06 yhdM; Zn(II)-responsive regulator of ZntA; COG: COG0789 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001452258.1 KEGG: ecj:JW5353 3.6e-278 yehU; predicted sensory kinase in two-component system with YehT K07704; COG: COG3275 Putative regulator of cell autolysis; Psort location: plasma membrane, score: 23 YP_001452259.1 unknown function; when overproduced it confers drug-resistance YP_001452260.1 COG: COG4807 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001452261.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_001452262.1 KEGG: eci:UTI89_C2387 7.4e-191 mrp; putative ATPase K03593; COG: COG0489 ATPases involved in chromosome partitioning; Psort location: cytoplasmic, score: 23 YP_001452263.1 COG: NOG18135 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001452264.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001452265.1 Psort location: mitochondrial, score: 23 YP_001452266.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001452267.1 KEGG: ddi:DDB0190674 0.0076 hypothetical protein K01146; COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001452268.1 COG: NOG07909 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001452269.1 COG: COG5455 Predicted integral membrane protein; Psort location: cytoplasmic, score: 23 YP_001452270.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP YP_001452271.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_001452272.1 KEGG: reh:H16_B1289 5.2e-16 phnF; regulator of phosphonate operon, GntR-family; COG: COG2188 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001452273.1 KEGG: ape:APE_0012 3.3e-14 ribokinase K00852; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001452274.1 KEGG: ecj:JW2086 8.0e-162 yegU; predicted hydrolase K05521; COG: COG1397 ADP-ribosylglycohydrolase; Psort location: mitochondrial, score: 23 YP_001452275.1 KEGG: eci:UTI89_C3355 6.2e-52 nupG; transport of nucleosides, permease protein K03289; COG: NOG06278 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001452276.1 Psort location: cytoplasmic, score: 23 YP_001452277.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate YP_001452278.1 KEGG: rle:pRL90117 2.1e-193 putative D-ribulokinase/ribitol kinase K00875; COG: COG1069 Ribulose kinase; Psort location: cytoplasmic, score: 23 YP_001452279.1 KEGG: rle:pRL90116 1.6e-94 putative ribitol 2-dehydrogenase K00039; COG: COG4221 Short-chain alcohol dehydrogenase of unknown specificity; Psort location: cytoplasmic, score: 23 YP_001452280.1 COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001452281.1 KEGG: sme:SMb20312 1.6e-26 putative transcriptional regulator protein K05878; COG: COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain; Psort location: cytoplasmic, score: 23 YP_001452282.1 KEGG: ype:YPO2325 8.0e-162 dalD; D-arabinitol 4-dehydrogenase K00007; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001452283.1 KEGG: bxe:Bxe_A0729 4.1e-158 xylulokinase K00854; COG: COG1070 Sugar (pentulose and hexulose) kinases; Psort location: cytoplasmic, score: 23 YP_001452284.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001452285.1 KEGG: aha:AHA_2118 2.8e-33 phosphatase YniC K01112; COG: COG0637 Predicted phosphatase/phosphohexomutase; Psort location: cytoplasmic, score: 23 YP_001452286.1 Psort location: cytoplasmic, score: 23 YP_001452287.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role YP_001452288.1 COG: COG1396 Predicted transcriptional regulators; Psort location: mitochondrial, score: 23 YP_001452289.1 COG: COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system; Psort location: cytoplasmic, score: 23 YP_001452290.1 KEGG: stm:STM2136 1.0e-241 yegQ; putative protease K08303; COG: COG0826 Collagenase and related proteases; Psort location: cytoplasmic, score: 23 YP_001452291.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport YP_001452292.1 KEGG: sec:SC2132 4.3e-227 baeS, baeR; sensory kinase in two-component regulatoyr system wtih BaeR K07642; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001452293.1 KEGG: sgl:SG1466 6.1e-08 deTHIobiotin synthase K01935; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001452294.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate YP_001452295.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate YP_001452296.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate YP_001452297.1 KEGG: eci:UTI89_C0016 9.6e-11 dnaK; chaperone HSP70; DNA biosynthesis; autoregulated heat shock proteins K04043; COG: COG0443 Molecular chaperone; Psort location: cytoplasmic, score: 23 YP_001452298.1 Psort location: extracellular, including cell wall, score: 9 YP_001452299.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine YP_001452300.1 contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction YP_001452301.1 Psort location: cytoplasmic, score: 23 YP_001452302.1 Psort location: cytoplasmic, score: 23 YP_001452303.1 KEGG: sty:STY2335 1.6e-53 udk; uridine kinase K00876; COG: COG0572 Uridine kinase; Psort location: cytoplasmic, score: 23 YP_001452304.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_001452305.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs YP_001452306.1 Psort location: mitochondrial, score: 23 YP_001452307.1 KEGG: eci:UTI89_C0656 1.0e-24 ybeX; putative transport protein K06189; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: plasma membrane, score: 23 YP_001452308.1 Psort location: cytoplasmic, score: 23 YP_001452309.1 Psort location: cytoplasmic, score: 23 YP_001452310.1 Psort location: mitochondrial, score: 23 YP_001452311.1 COG: COG1596 Periplasmic protein involved in polysaccharide export; Psort location: extracellular, including cell wall, score: 9 YP_001452312.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis YP_001452313.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide) YP_001452314.1 KEGG: eci:UTI89_C2333 2.8e-143 wcaA; putative colanic acid biosynthesis glycosyltransferase WcaA; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: mitochondrial, score: 23 YP_001452315.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium YP_001452316.1 KEGG: eci:UTI89_C2331 1.5e-190 wcaC; putative glycosyltransferase K00754; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001452317.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance YP_001452318.1 KEGG: eci:UTI89_C2329 1.8e-93 wcaE; putative colanic acid biosynthesis glycosyl transferase; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001452319.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit) YP_001452320.1 KEGG: stm:STM2109 2.4e-194 gmd; GDP-D-mannose dehydratase K01711; COG: COG1089 GDP-D-mannose dehydratase; Psort location: cytoplasmic, score: 23 YP_001452321.1 KEGG: ecc:c2578 3.2e-158 wcaG; GDP-fucose synthetase K02377; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001452322.1 KEGG: eci:UTI89_C2325 4.7e-70 wcaH; mannose-1-phosphate guanylyltransferase (GDP) K03207; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001452323.1 KEGG: eci:UTI89_C2324 2.3e-187 wcaI; putative colanic biosynthesis glycosyl transferase K03208; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001452324.1 KEGG: ecp:ECP_2089 1.3e-248 mannose-1-phosphate guanylyltransferase K00971; COG: COG0662 Mannose-6-phosphate isomerase; Psort location: mitochondrial, score: 23 YP_001452325.1 KEGG: ecc:c2573 1.5e-233 cpsG; phosphomannomutase K01840; COG: COG1109 Phosphomannomutase; Psort location: cytoplasmic, score: 23 YP_001452326.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid YP_001452327.1 COG: COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; Psort location: plasma membrane, score: 23 YP_001452328.1 Psort location: mitochondrial, score: 23 YP_001452329.1 KEGG: sbo:SBO_0872 2.4e-208 wcaK; putative galactokinase K00849; COG: COG2327 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001452330.1 KEGG: stm:STM2100 2.3e-180 wcaL; putative glycosyl transferase in colanic acid gene cluster; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001452331.1 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid YP_001452332.1 Psort location: nuclear, score: 23 YP_001452333.1 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose YP_001452334.1 COG: COG3562 Capsule polysaccharide export protein; Psort location: cytoplasmic, score: 23 YP_001452335.1 Psort location: nuclear, score: 23 YP_001452336.1 Psort location: plasma membrane, score: 23 YP_001452338.1 Psort location: nuclear, score: 23 YP_001452339.1 KEGG: hhe:HH1591 0.0057 nuoM; donor-ubiquinone reductase I K00342; COG: COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; Psort location: plasma membrane, score: 23 YP_001452340.1 KEGG: lsl:LSL_1574 3.7e-47 rfaG; glycosyltransferase K00754; COG: NOG09872 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452341.1 KEGG: lsl:LSL_1527 1.8e-08 O-acetyl transferase K00680; COG: COG3594 Fucose 4-O-acetylase and related acetyltransferases; Psort location: endoplasmic reticulum, score: 9 YP_001452342.1 KEGG: pde:Pden_5043 3.9e-137 UDP-galactopyranose mutase K01854; COG: COG0562 UDP-galactopyranose mutase; Psort location: endoplasmic reticulum, score: 9 YP_001452343.1 KEGG: stm:STM2082 2.0e-213 rfbP; LPS side chain defect: bifunctional enzyme: undecaprenol-phosphate galactosephosphotransferase, and O-antigen transfer K00996; COG: COG2148 Sugar transferases involved in lipopolysaccharide synthesis; Psort location: endoplasmic reticulum, score: 9 YP_001452344.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_001452345.1 KEGG: ecp:ECP_2071 2.4e-185 UDP-glucose 6-dehydrogenase K00012; COG: COG1004 Predicted UDP-glucose 6-dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001452346.1 KEGG: aci:ACIAD0068 4.3e-05 ptk; tyrosine-protein kinase, autophosphorylates K00903; COG: COG3765 Chain length determinant protein; Psort location: endoplasmic reticulum, score: 9 YP_001452347.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis YP_001452348.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_001452349.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_001452350.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_001452351.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate YP_001452352.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001452353.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_001452354.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_001452355.1 Psort location: cytoplasmic, score: 23 YP_001452356.1 KEGG: mth:MTH1789 1.2e-07 dTDP-glucose 4,6-dehydratase K01710; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: endoplasmic reticulum, score: 9 YP_001452357.1 KEGG: shn:Shewana3_3435 0.0011 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001452358.1 Psort location: mitochondrial, score: 23 YP_001452359.1 Psort location: mitochondrial, score: 23 YP_001452360.1 KEGG: eci:UTI89_C0120 4.2e-13 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001452361.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates YP_001452362.1 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_001452363.1 COG: COG3449 DNA gyrase inhibitor; Psort location: cytoplasmic, score: 23 YP_001452364.1 COG: COG1289 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001452365.1 KEGG: pac:PPA1242 0.0094 ATP synthase delta chain K02113; COG: COG2926 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001452366.1 KEGG: lwe:lwe1128 1.4e-38 propanediol utilization kinase PduX K01009; COG: COG4542 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase; Psort location: cytoplasmic, score: 23 YP_001452367.1 involved in coenzyme B(12)-dependent 1, 2-propanediol degradation; important for the synthesis of propionyl coenzyme A during growth on 1,2-propanediol YP_001452368.1 KEGG: ctc:CTC01446 3.3e-14 lysine-sensitive aspartokinase III K00928; COG: COG4917 Ethanolamine utilization protein; Psort location: mitochondrial, score: 23 YP_001452369.1 COG: COG4810 Ethanolamine utilization protein; Psort location: cytoplasmic, score: 23 YP_001452370.1 COG: COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: cytoplasmic, score: 23 YP_001452371.1 KEGG: eci:UTI89_C1819 3.8e-38 rnfC; electron transport complex protein RnfC K03615; COG: COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC; Psort location: cytoplasmic, score: 23 YP_001452372.1 KEGG: spt:SPA0819 7.0e-163 pduQ; putative propanol dehydrogenase K00100; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: cytoplasmic, score: 23 YP_001452373.1 KEGG: rru:Rru_A0914 1.9e-112 aldehyde dehydrogenase K04021; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001452374.1 KEGG: noc:Noc_0867 1.2e-27 cobalamin adenosyltransferase K00798; COG: COG2096 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001452375.1 COG: COG4576 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: mitochondrial, score: 23 YP_001452376.1 COG: NOG15374 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001452377.1 KEGG: dar:Daro_2921 6.2e-41 acetate kinase K00925; COG: COG4869 Propanediol utilization protein; Psort location: cytoplasmic, score: 23 YP_001452378.1 COG: COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: nuclear, score: 23 YP_001452379.1 COG: COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: cytoplasmic, score: 23 YP_001452380.1 KEGG: ssn:SSO_2061 0.00025 pduD; putative propanediol utilization protein: diol dehydratase medium subunit K06121; COG: NOG12182 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452381.1 COG: NOG06036 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452382.1 KEGG: sec:SC2050 7.6e-79 pduE; propanediol utilization: dehydratase, small subunit K06122; COG: COG4910 Propanediol dehydratase, small subunit; Psort location: nuclear, score: 23 YP_001452383.1 KEGG: stm:STM2041 2.4e-107 pduD; Propanediol utilization: dehydratase, medium subunit K06121; COG: COG4909 Propanediol dehydratase, large subunit; Psort location: nuclear, score: 23 YP_001452384.1 KEGG: stm:STM2040 2.0e-291 pduC; glycerol dehydratase large subunit K06120; COG: COG4909 Propanediol dehydratase, large subunit; Psort location: cytoplasmic, score: 23 YP_001452385.1 KEGG: ama:AM747 0.0038 nuoK; NADH dehydrogenase chain K K00340; COG: COG4816 Ethanolamine utilization protein; Psort location: endoplasmic reticulum, score: 9 YP_001452386.1 COG: COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: cytoplasmic, score: 23 YP_001452387.1 KEGG: fal:FRAAL3366 1.2e-05 putative arsenate reductase (partial match); COG: COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family); Psort location: endoplasmic reticulum, score: 9 YP_001452388.1 KEGG: bha:BH0394 1.8e-11 adaA; methylphosphotriester-DNA alkyltransferase (AraC/XylS family) K00567; COG: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; Psort location: nuclear, score: 23 YP_001452389.1 Psort location: cytoplasmic, score: 23 YP_001452390.1 Psort location: mitochondrial, score: 23 YP_001452391.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid YP_001452392.1 CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group YP_001452393.1 catalyzes the interconversion of cobalt-precorrin-8X and cobyrinic acid in the anaerobic biosynthesis of cobalamin YP_001452394.1 Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A YP_001452395.1 catalyzes the methylation of C-5 in cobalt-precorrin-6Y to form cobalt-precorrin-7W-a YP_001452396.1 catalyzes the methylation of either C-15 or C-5 in cobalt-precorrin-6Y to form cobalt-precorrin-7W; decarboxylating YP_001452397.1 KEGG: stm:STM2029 6.7e-126 cbiF; precorrin-4 C11-methyltransferase K03396; COG: COG2875 Precorrin-4 methylase; Psort location: cytoplasmic, score: 23 YP_001452398.1 catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3 YP_001452399.1 KEGG: sty:STY2232 2.4e-121 cbiH; precorrin-3 C17-methyltransferase K03395; COG: COG1010 Precorrin-3B methylase; Psort location: cytoplasmic, score: 23 YP_001452400.1 CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6 YP_001452401.1 KEGG: sec:SC2033 1.4e-127 cbiK; synthesis of vitamin B12 adenosyl cobalamide precursor K02190; COG: COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase; Psort location: cytoplasmic, score: 23 YP_001452402.1 catalyzes the formation of precorrin-3A from precorrin-2 YP_001452403.1 catalyzes the ATP-dependent transport of cobalt YP_001452404.1 periplasmic cobalt binding component of the cobalt transport system YP_001452405.1 COG: COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters; Psort location: endoplasmic reticulum, score: 9 YP_001452406.1 with CbiNQ forms the ABC transporter for cobalt import YP_001452407.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation YP_001452408.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP YP_001452409.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole YP_001452410.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole YP_001452411.1 KEGG: eci:UTI89_C2228 1.0e-136 erfK; hypothetical protein K00257; COG: COG1376 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001452412.1 KEGG: shn:Shewana3_3435 7.1e-28 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001452413.1 COG: NOG14366 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452414.1 COG: COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component; Psort location: mitochondrial, score: 23 YP_001452415.1 Psort location: nuclear, score: 23 YP_001452416.1 COG: NOG26784 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001452417.1 COG: NOG18512 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452418.1 KEGG: eco:b0581 3.8e-52 ybdK; gamma-glutamyl:cysteine ligase; COG: COG2170 Uncharacterized conserved protein; Psort location: mitochondrial, score: 23 YP_001452419.1 COG: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family; Psort location: cytoplasmic, score: 23 YP_001452420.1 KEGG: tbd:Tbd_2559 0.0074 dsbD; THIol:disulfide interchange protein DsbD K04084; COG: COG0609 ABC-type Fe3+-siderophore transport system, permease component; Psort location: plasma membrane, score: 23 YP_001452421.1 KEGG: ava:Ava_0005 3.5e-12 probable methyltransferase K00598; COG: NOG36168 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452422.1 COG: COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001452423.1 KEGG: shn:Shewana3_2312 0.0015 1-(5-phosphoribosyl)-5- K01814; COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: extracellular, including cell wall, score: 9 YP_001452424.1 COG: COG0534 Na+-driven multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001452425.1 COG: COG3122 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001452426.1 COG: NOG29101 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452427.1 KEGG: reh:H16_A0904 7.9e-38 ABC-type transporter, ATPase and permease components: LipidE family K01530; COG: COG1132 ABC-type multidrug transport system, ATPase and permease components; Psort location: endoplasmic reticulum, score: 9 YP_001452428.1 COG: COG1733 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001452429.1 COG: NOG17459 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452430.1 KEGG: rsp:RSP_2029 1.6e-92 ucpA; short chain dehydrogenase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001452431.1 COG: NOG37168 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001452432.1 Psort location: cytoplasmic, score: 23 YP_001452433.1 KEGG: rru:Rru_A2865 3.2e-119 peptidase M24 K01262; COG: COG0006 Xaa-Pro aminopeptidase; Psort location: cytoplasmic, score: 23 YP_001452434.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile YP_001452435.1 KEGG: cal:orf19.5753 0.0028 STL1; sugar transporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001452436.1 KEGG: eca:ECA4254 1.8e-61 putative iron(III) ABC transporter ATP-binding protein K02013; COG: COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components; Psort location: mitochondrial, score: 23 YP_001452437.1 COG: COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component; Psort location: endoplasmic reticulum, score: 9 YP_001452438.1 COG: COG0609 ABC-type Fe3+-siderophore transport system, permease component; Psort location: plasma membrane, score: 23 YP_001452439.1 Psort location: cytoplasmic, score: 23 YP_001452440.1 KEGG: nwi:Nwi_0782 8.6e-09 integrase, catalytic region K00986; COG: COG2801 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001452441.1 Psort location: cytoplasmic, score: 23 YP_001452442.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001452443.1 KEGG: syn:slr0495 6.5e-18 lipopeptide antibiotics iturin a biosynthesis protein K01005; COG: COG2091 Phosphopantetheinyl transferase; Psort location: cytoskeletal, score: 9 YP_001452444.1 KEGG: ava:Ava_B0209 3.1e-06 two component transcriptional regulator, LuxR family K02479; COG: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; Psort location: nuclear, score: 23 YP_001452445.1 KEGG: ava:Ava_4834 1.1e-184 beta-ketoacyl synthase K01845; COG: COG3321 Polyketide synthase modules and related proteins; Psort location: endoplasmic reticulum, score: 9 YP_001452446.1 Psort location: cytoplasmic, score: 23 YP_001452447.1 KEGG: ava:Ava_4834 7.3e-125 beta-ketoacyl synthase K01845; COG: COG3321 Polyketide synthase modules and related proteins; Psort location: cytoplasmic, score: 23 YP_001452448.1 KEGG: ecc:c2467 1.0e-152 bhbD; putative 3-hydroxyacyl-CoA dehydrogenase K00074; COG: COG1250 3-hydroxyacyl-CoA dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001452449.1 KEGG: ecp:ECP_1976 3.3e-37 putative D-alanyl carrier protein K03367; Psort location: cytoplasmic, score: 23 YP_001452450.1 Psort location: cytoplasmic, score: 23 YP_001452451.1 KEGG: ecp:ECP_1975 1.9e-199 putative acyl-CoA dehydrogenase K00257; COG: COG1960 Acyl-CoA dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001452452.1 KEGG: ecp:ECP_1974 1.0e-223 putative malonyl-CoA transacylase K00645; COG: COG0331 (acyl-carrier-protein) S-malonyltransferase; Psort location: cytoplasmic, score: 23 YP_001452453.1 KEGG: rha:RHA1_ro06103 2.1e-198 non-ribosomal peptide synthetase K01779:K01897; COG: COG1020 Non-ribosomal peptide synthetase modules and related proteins; Psort location: plasma membrane, score: 23 YP_001452454.1 KEGG: ava:Ava_4834 7.6e-205 beta-ketoacyl synthase K01845; COG: COG3321 Polyketide synthase modules and related proteins; Psort location: cytoplasmic, score: 23 YP_001452455.1 KEGG: eci:UTI89_C2214 0. putative peptide synthetase K01932; COG: COG1020 Non-ribosomal peptide synthetase modules and related proteins; Psort location: cytoplasmic, score: 23 YP_001452456.1 KEGG: eci:UTI89_C2214 0. putative peptide synthetase K01932; COG: COG3321 Polyketide synthase modules and related proteins; Psort location: cytoplasmic, score: 23 YP_001452457.1 KEGG: eci:UTI89_C2212 1.0e-264 putative amidase K01426; COG: COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases; Psort location: cytoplasmic, score: 23 YP_001452458.1 KEGG: tfu:Tfu_2682 0.0012 proton-translocating NADH-quinone oxidoreductase, chain N K00343; COG: COG0534 Na+-driven multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001452459.1 KEGG: eci:UTI89_C2210 0. putative peptide synthetase K03367; COG: COG1020 Non-ribosomal peptide synthetase modules and related proteins; Psort location: vacuolar, score: 9 YP_001452460.1 KEGG: ava:Ava_4834 1.6e-101 beta-ketoacyl synthase K01845; COG: COG3321 Polyketide synthase modules and related proteins; Psort location: cytoplasmic, score: 23 YP_001452461.1 KEGG: eci:UTI89_C2208 1.6e-259 hypothetical protein K01286; COG: COG1680 Beta-lactamase class C and other penicillin binding proteins; Psort location: endoplasmic reticulum, score: 9 YP_001452462.1 KEGG: eci:UTI89_C2207 9.8e-102 putative THIoesterase K01076; COG: COG3208 Predicted THIoesterase involved in non-ribosomal peptide biosynthesis; Psort location: cytoplasmic, score: 23 YP_001452463.1 COG: COG4283 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001452464.1 Psort location: cytoplasmic, score: 23 YP_001452465.1 COG: NOG22282 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452466.1 COG: NOG23110 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001452467.1 Psort location: mitochondrial, score: 23 YP_001452468.1 Psort location: endoplasmic reticulum, score: 9 YP_001452469.1 Psort location: nuclear, score: 23 YP_001452470.1 COG: NOG33965 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001452471.1 Psort location: extracellular, including cell wall, score: 9 YP_001452472.1 KEGG: pen:PSEEN0648 7.7e-22 type II/IV secretion system protein E; COG: COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis; Psort location: cytoplasmic, score: 23 YP_001452473.1 Psort location: endoplasmic reticulum, score: 9 YP_001452474.1 Psort location: mitochondrial, score: 23 YP_001452475.1 COG: COG2948 Type IV secretory pathway, VirB10 components; Psort location: nuclear, score: 23 YP_001452476.1 COG: COG3504 Type IV secretory pathway, VirB9 components; Psort location: extracellular, including cell wall, score: 9 YP_001452477.1 COG: COG3736 Type IV secretory pathway, component VirB8; Psort location: endoplasmic reticulum, score: 9 YP_001452478.1 Psort location: extracellular, including cell wall, score: 9 YP_001452479.1 COG: COG3704 Type IV secretory pathway, VirB6 components; Psort location: endoplasmic reticulum, score: 9 YP_001452480.1 Psort location: nuclear, score: 23 YP_001452481.1 COG: NOG13363 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001452482.1 COG: COG3451 Type IV secretory pathway, VirB4 components; Psort location: endoplasmic reticulum, score: 9 YP_001452483.1 COG: NOG22876 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001452484.1 COG: NOG17192 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001452485.1 COG: NOG33328 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452486.1 Psort location: cytoplasmic, score: 23 YP_001452487.1 COG: NOG13543 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452488.1 COG: NOG11459 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001452489.1 COG: COG3311 Predicted transcriptional regulator; Psort location: mitochondrial, score: 23 YP_001452490.1 COG: NOG32955 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452491.1 COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: extracellular, including cell wall, score: 9 YP_001452492.1 KEGG: ypk:y2403 7.4e-278 ybtE; salicyl-AMP ligase K04783; COG: COG1021 Peptide arylation enzymes; Psort location: cytoplasmic, score: 23 YP_001452493.1 KEGG: eci:UTI89_C2186 2.1e-138 ybtT; YbtT protein K05374; COG: COG3208 Predicted THIoesterase involved in non-ribosomal peptide biosynthesis; Psort location: extracellular, including cell wall, score: 9 YP_001452494.1 KEGG: bme:BMEII1126 0.0097 oxidoreductase K00100; COG: COG4693 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis; Psort location: endoplasmic reticulum, score: 9 YP_001452495.1 KEGG: eci:UTI89_C2184 0. irp1; HMWP1 nonribosomal peptide/polyketide synthase K04786; COG: COG3319 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases; Psort location: cytoplasmic, score: 23 YP_001452496.1 KEGG: eci:UTI89_C2184 2.6e-16 irp1; HMWP1 nonribosomal peptide/polyketide synthase K04786; COG: COG3433 Aryl carrier domain; Psort location: cytoplasmic, score: 23 YP_001452497.1 KEGG: bur:Bcep18194_B0672 4.1e-190 non-ribosomal peptide synthetase modules K01776; COG: COG3433 Aryl carrier domain; Psort location: cytoplasmic, score: 23 YP_001452498.1 KEGG: bur:Bcep18194_C7173 1.1e-06 two component transcriptional regulator, AraC family; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: nuclear, score: 23 YP_001452499.1 KEGG: rru:Rru_A0864 2.5e-80 ABC transporter, transmembrane region K06020; COG: COG1132 ABC-type multidrug transport system, ATPase and permease components; Psort location: endoplasmic reticulum, score: 9 YP_001452500.1 KEGG: pen:PSEEN2497 1.0e-81 ABC transporter, permease/ATP-binding protein; COG: COG1132 ABC-type multidrug transport system, ATPase and permease components; Psort location: endoplasmic reticulum, score: 9 YP_001452501.1 KEGG: eci:UTI89_C0457 6.2e-19 ampG; AmpG muropeptide MFS transporter K08218; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001452502.1 catalyzes the conversion of chorismate to salicylate in the biosynthesis of the siderophore yersiniabactin YP_001452503.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001452504.1 Psort location: nuclear, score: 23 YP_001452505.1 Psort location: cytoplasmic, score: 23 YP_001452506.1 COG: COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001452507.1 COG: COG0609 ABC-type Fe3+-siderophore transport system, permease component; Psort location: plasma membrane, score: 23 YP_001452508.1 COG: COG0735 Fe2+/Zn2+ uptake regulation proteins; Psort location: nuclear, score: 23 YP_001452509.1 KEGG: pfl:PFL_6181 7.7e-22 phosphoribosyl-AMP cyclohydrolase K01496; COG: COG0139 Phosphoribosyl-AMP cyclohydrolase; Psort location: cytoplasmic, score: 23 YP_001452510.1 KEGG: mth:MTH245 2.6e-07 phosphoribosyl-AMP cyclohydrolase K01496; Psort location: cytoplasmic, score: 23 YP_001452511.1 KEGG: ret:RHE_CH02713 1.1e-123 probable cobalamin synthesis protein; COG: COG0523 Putative GTPases (G3E family); Psort location: cytoplasmic, score: 23 YP_001452512.1 Psort location: cytoplasmic, score: 23 YP_001452513.1 COG: COG0370 Fe2+ transport system protein B; Psort location: plasma membrane, score: 23 YP_001452514.1 KEGG: bld:BLi00763 4.2e-69 hypothetical protein K00100; COG: COG0492 Thioredoxin reductase; Psort location: mitochondrial, score: 23 YP_001452515.1 KEGG: eca:ECA3151 1.2e-151 cysS; cysteinyl-RNA synthetase K01883; COG: COG0215 Cysteinyl-tRNA synthetase; Psort location: cytoplasmic, score: 23 YP_001452516.1 COG: COG0735 Fe2+/Zn2+ uptake regulation proteins; Psort location: mitochondrial, score: 23 YP_001452517.1 KEGG: ftf:FTF1000c 2.1e-28 cobS; cobalamin (vitamin B12) synthesis protein/P47K family protein; COG: COG0523 Putative GTPases (G3E family); Psort location: mitochondrial, score: 23 YP_001452518.1 COG: COG1734 DnaK suppressor protein; Psort location: nuclear, score: 23 YP_001452519.1 similar protein in Methanocaldococcus converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate as the first step in methanopterin biosynthesis YP_001452520.1 KEGG: pen:PSEEN3120 1.9e-59 carbonate dehydratase K01672; COG: COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily; Psort location: cytoplasmic, score: 23 YP_001452521.1 KEGG: shn:Shewana3_2424 1.6e-55 isocitrate dehydrogenase (NADP(+)) K00031; COG: NOG08609 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452522.1 COG: NOG10019 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001452523.1 COG: COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; Psort location: plasma membrane, score: 23 YP_001452524.1 COG: COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; Psort location: plasma membrane, score: 23 YP_001452525.1 KEGG: rru:Rru_A2894 8.9e-76 ABC transporter component K02074; COG: COG1121 ABC-type Mn/Zn transport systems, ATPase component; Psort location: cytoplasmic, score: 23 YP_001452526.1 COG: COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin; Psort location: extracellular, including cell wall, score: 9 YP_001452527.1 KEGG: pfl:PFL_6184 3.7e-196 thrS; threonyl-tRNA synthetase K01868; COG: COG0441 Threonyl-tRNA synthetase; Psort location: cytoplasmic, score: 23 YP_001452528.1 COG: NOG26672 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452529.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides YP_001452530.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001452531.1 Psort location: cytoplasmic, score: 23 YP_001452532.1 KEGG: rde:RD1_3144 3.9e-18 fructosyl-amino acid oxidase, putative; COG: COG0665 Glycine/D-amino acid oxidases (deaminating); Psort location: extracellular, including cell wall, score: 9 YP_001452533.1 Psort location: extracellular, including cell wall, score: 9 YP_001452534.1 COG: NOG07584 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001452535.1 COG: COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin; Psort location: cytoplasmic, score: 23 YP_001452536.1 COG: COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001452537.1 KEGG: azo:azo0642 6.0e-54 mntA1; putative manganese transport system, ATP-asa protein; COG: COG1121 ABC-type Mn/Zn transport systems, ATPase component; Psort location: cytoplasmic, score: 23 YP_001452538.1 KEGG: reh:H16_A0369 4.8e-100 rfbB1; dTDP-D-glucose 4,6-dehydratase K01710; COG: COG3211 Predicted phosphatase; Psort location: cytoplasmic, score: 23 YP_001452539.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001452540.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation YP_001452541.1 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB YP_001452542.1 COG: COG3228 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001452543.1 Psort location: nuclear, score: 23 YP_001452544.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: endoplasmic reticulum, score: 9 YP_001452545.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001452546.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001452547.1 KEGG: ech:ECH_0340 0.0064 gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) K00057; COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001452548.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: mitochondrial, score: 23 YP_001452549.1 KEGG: shn:Shewana3_3829 5.3e-06 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) K01745; COG: COG2200 FOG: EAL domain; Psort location: cytoplasmic, score: 23 YP_001452550.1 COG: COG4566 Response regulator; Psort location: nuclear, score: 23 YP_001452551.1 COG: COG5581 Predicted glycosyltransferase; Psort location: nuclear, score: 23 YP_001452552.1 KEGG: shn:Shewana3_3063 5.2e-05 phosphatidylglycerophosphatase K01094; COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: cytoplasmic, score: 23 YP_001452553.1 KEGG: ssn:SSO_3604 9.3e-200 iucD; lysine:N6-hydroxylase K03897; COG: COG3486 Lysine/orniTHIne N-monooxygenase; Psort location: cytoplasmic, score: 23 YP_001452554.1 KEGG: ecc:c3625 0. iucC; iucC protein K03895; COG: COG4264 Siderophore synthetase component; Psort location: cytoplasmic, score: 23 YP_001452555.1 KEGG: sbo:SBO_4338 2.2e-166 iucB; siderophore biosynthesis protein K03896; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001452556.1 KEGG: sfl:SF3715 1.5e-238 iucA; aerobactin synthetase subunit alpha K03894; COG: COG4264 Siderophore synthetase component; Psort location: cytoplasmic, score: 23 YP_001452557.1 Psort location: cytoplasmic, score: 23 YP_001452558.1 Psort location: endoplasmic reticulum, score: 9 YP_001452559.1 KEGG: aci:ACIAD2291 0.0069 cydB; cytochrome d terminal oxidase polypeptide subunit II K00426; COG: NOG06795 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001452560.1 Psort location: extracellular, including cell wall, score: 9 YP_001452561.1 COG: COG2375 Siderophore-interacting protein; Psort location: cytoplasmic, score: 23 YP_001452562.1 COG: COG3203 Outer membrane protein (porin); Psort location: extracellular, including cell wall, score: 9 YP_001452563.1 COG: COG1418 Predicted HD superfamily hydrolase; Psort location: cytoplasmic, score: 23 YP_001452564.1 KEGG: stm:STM1992 1.4e-228 dcm; DNA cytosine methylase K00558; COG: COG0270 Site-specific DNA methylase; Psort location: cytoplasmic, score: 23 YP_001452565.1 KEGG: eci:UTI89_C2161 6.5e-73 vsr; DNA mismatch endonuclease, patch repair protein K07458; COG: COG3727 DNA G:T-mismatch repair endonuclease; Psort location: cytoplasmic, score: 23 YP_001452566.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001452567.1 Psort location: cytoplasmic, score: 23 YP_001452568.1 COG: COG2354 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 23 YP_001452569.1 COG: COG5475 Uncharacterized small protein; Psort location: cytoplasmic, score: 23 YP_001452570.1 Psort location: mitochondrial, score: 23 YP_001452571.1 KEGG: bpm:BURPS1710b_A1493 5.1e-24 GGDEF domain protein; COG: COG2199 FOG: GGDEF domain; Psort location: cytoplasmic, score: 23 YP_001452572.1 COG: NOG14111 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452573.1 COG: NOG14105 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452574.1 COG: COG2771 DNA-binding HTH domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001452575.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus YP_001452576.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus YP_001452577.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_001452578.1 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus YP_001452579.1 One of three proteins involved in switching the direction of the flagellar rotation YP_001452580.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation YP_001452581.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring YP_001452582.1 KEGG: reh:H16_A2389 0.0032 dnaX; DNA polymerase III tau/gamma subunit K00961; COG: COG3144 Flagellar hook-length control protein; Psort location: nuclear, score: 23 YP_001452583.1 rod/hook and filament chaperone YP_001452584.1 involved in type III protein export during flagellum assembly YP_001452585.1 binds to and inhibits the function of flagella specific ATPase FliI YP_001452586.1 One of three proteins involved in switching the direction of the flagellar rotation YP_001452587.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_001452588.1 Psort location: cytoplasmic, score: 23 YP_001452589.1 forms a junction between the M-ring and FlgB during flagella biosynthesis YP_001452590.1 COG: COG0425 Predicted redox protein, regulator of disulfide bond formation; Psort location: nuclear, score: 23 YP_001452591.1 COG: COG2391 Predicted transporter component; Psort location: endoplasmic reticulum, score: 9 YP_001452592.1 KEGG: plu:plu1239 0.0072 dinP; DNA polymerase IV (DNA-damage-inducible protein P) K02346; COG: NOG09020 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001452593.1 converts 1,4-alpha-D-glucans to maltodextrin YP_001452594.1 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family YP_001452595.1 flagellin specific chaperone YP_001452596.1 KEGG: cal:orf19.4072 4.6e-07 HYR10; similar to cell surface flocculin K01186; COG: COG1345 Flagellar capping protein; Psort location: nuclear, score: 23 YP_001452597.1 KEGG: chu:CHU_3220 0.00018 CHU large protein; uncharacterized K01238; COG: COG1344 Flagellin and related hook-associated proteins; Psort location: nuclear, score: 23 YP_001452598.1 KEGG: dme:Dmel_CG10392 1.9e-36 Ogt; O-glycosyltransferase K00754; COG: COG3914 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family; Psort location: cytoplasmic, score: 23 YP_001452599.1 COG: NOG17471 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452600.1 KEGG: lic:LIC12268 0.0034 putative glycolate oxidase K00016; COG: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Psort location: cytoplasmic, score: 23 YP_001452601.1 COG: NOG13976 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452603.1 COG: NOG10098 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001452604.1 KEGG: psp:PSPPH_3420 6.3e-130 aminotransferase, DegT/DnrJ/EryC1/StrS family K01726; COG: COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001452605.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes YP_001452606.1 expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence YP_001452607.1 KEGG: eci:UTI89_C2121 1.1e-132 fliY; cystine-binding periplasmic protein precursor K02030:K02424; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: endoplasmic reticulum, score: 9 YP_001452608.1 catalyzes the formation of pyruvate from D-cysteine YP_001452609.1 KEGG: hpa:HPAG1_0922 8.3e-41 amino acid ABC transporter, permease protein; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001452610.1 KEGG: ssn:SSO_1201 5.8e-120 yecC; putative ATP-binding component of a transport system K02028; COG: COG1126 ABC-type polar amino acid transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001452611.1 regulates genes involved in cell division YP_001452612.1 COG: NOG13894 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001452613.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system YP_001452614.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001452615.1 KEGG: stt:t0931 2.1e-92 pgsA; phosphotidylglycerophosphate synthetase K00995; COG: COG0558 Phosphatidylglycerophosphate synthase; Psort location: endoplasmic reticulum, score: 9 YP_001452616.1 Psort location: nuclear, score: 23 YP_001452618.1 COG: COG3318 Predicted metal-binding protein related to the C-terminal domain of SecA; Psort location: cytoplasmic, score: 23 YP_001452619.1 COG: COG0814 Amino acid permeases; Psort location: endoplasmic reticulum, score: 9 YP_001452620.1 COG: NOG14112 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452621.1 cytoplasmic iron storage protein YP_001452622.1 COG: NOG11332 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001452623.1 KEGG: stm:STM1933 2.5e-103 hypothetical protein K01806; COG: COG0698 Ribose 5-phosphate isomerase RpiB; Psort location: cytoplasmic, score: 23 YP_001452624.1 COG: NOG15359 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452625.1 KEGG: cel:D1037.3 0.00053 ferritin; D1037.3 K00522; COG: COG1528 Ferritin-like protein; Psort location: cytoplasmic, score: 23 YP_001452626.1 Psort location: mitochondrial, score: 23 YP_001452627.1 Psort location: mitochondrial, score: 23 YP_001452628.1 KEGG: lic:LIC11685 1.1e-15 4-methyl-5(b-hydroxyethyl)-THIazole monophosphate biosynthesis K03152; COG: COG0693 Putative intracellular protease/amidase; Psort location: extracellular, including cell wall, score: 23 YP_001452629.1 KEGG: aha:AHA_1903 1.8e-139 L-arabinose ABC transporter, periplasmic L-arabinose-binding protein; COG: COG1879 ABC-type sugar transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001452630.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_001452631.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_001452632.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature YP_001452633.1 KEGG: stt:t0949 1.3e-239 otsA; trehalose-6-phosphate synthase K00697; COG: COG0380 Trehalose-6-phosphate synthase; Psort location: cytoplasmic, score: 23 YP_001452634.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress YP_001452635.1 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems YP_001452636.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems YP_001452637.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_001452638.1 Psort location: extracellular, including cell wall, score: 9 YP_001452639.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_001452640.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component YP_001452641.1 KEGG: eci:UTI89_C2090 2.1e-76 cheW; CheW positive regulator of CheA protein activity K03408; COG: COG0835 Chemotaxis signal transduction protein; Psort location: cytoplasmic, score: 23 YP_001452642.1 Psort location: mitochondrial, score: 23 YP_001452643.1 KEGG: eci:UTI89_C4668 1.1e-68 gltP; glutamate-aspartate symport protein K03309; COG: COG1301 Na+/H+-dicarboxylate symporters; Psort location: plasma membrane, score: 23 YP_001452644.1 Psort location: nuclear, score: 23 YP_001452645.1 KEGG: vpa:VPA0675 4.1e-12 torS; sensor protein TorS K07647; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001452646.1 mediates taxis toward dipeptides YP_001452647.1 methylates the MCP YP_001452648.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_001452649.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble YP_001452650.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation YP_001452651.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: cytoplasmic, score: 23 YP_001452652.1 Psort location: cytoplasmic, score: 23 YP_001452653.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: nuclear, score: 23 YP_001452654.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001452655.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001452656.1 Psort location: extracellular, including cell wall, score: 9 YP_001452657.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_001452658.1 membrane protein involved in the flagellar export apparatus YP_001452659.1 COG: NOG12148 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001452660.1 KEGG: eci:UTI89_C4210 2.0e-19 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001452661.1 COG: COG4225 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins; Psort location: cytoplasmic, score: 23 YP_001452662.1 KEGG: eci:UTI89_C0637 1.6e-195 mrdA; cell elongation, e phase; peptidoglycan synthetase; penicillin-binding protein 2 K05515; COG: COG0768 Cell division protein FtsI/penicillin-binding protein 2; Psort location: cytoplasmic, score: 23 YP_001452663.1 Psort location: cytoplasmic, score: 23 YP_001452664.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001452665.1 Psort location: mitochondrial, score: 23 YP_001452666.1 COG: COG3102 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001452667.1 COG: COG3142 Uncharacterized protein involved in copper resistance; Psort location: cytoplasmic, score: 23 YP_001452668.1 Psort location: cytoplasmic, score: 23 YP_001452669.1 KEGG: eci:UTI89_C2075 3.0e-162 yecP; hypothetical protein K00599; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001452670.1 KEGG: eci:UTI89_C2074 2.7e-122 yecO; hypothetical protein K00559; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001452671.1 KEGG: hsa:4056 1.3e-05 LTC4S; leukotriene C4 synthase K00807; COG: COG3788 Uncharacterized relative of glutaTHIone S-transferase, MAPEG superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001452672.1 COG: COG1801 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001452673.1 KEGG: eci:UTI89_C2071 1.3e-81 yecD; hypothetical protein; COG: COG1335 Amidases related to nicotinamidase; Psort location: cytoplasmic, score: 23 YP_001452674.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001452675.1 converts dATP to dAMP and pyrophosphate YP_001452676.1 KEGG: eci:UTI89_C2068 4.6e-127 yebC; hypothetical protein K00975; COG: COG0217 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001452677.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_001452678.1 Psort location: cytoplasmic, score: 23 YP_001452679.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001452680.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001452681.1 Psort location: cytoplasmic, score: 23 YP_001452682.1 Psort location: cytoplasmic, score: 23 YP_001452683.1 involved in transport of zinc(II) with ZnuA and C YP_001452684.1 involved in transport of zinc(II) with ZnuA and C YP_001452685.1 involved in transport of zinc(II) with ZnuA and C YP_001452686.1 KEGG: spt:SPA0979 8.4e-215 yebA; hypothetical protein; COG: COG0739 Membrane proteins related to metalloendopeptidases; Psort location: cytoplasmic, score: 23 YP_001452687.1 Psort location: mitochondrial, score: 23 YP_001452688.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA YP_001452689.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001452690.1 Represses the expression of the zwf, eda, glp and gap YP_001452691.1 Psort location: cytoplasmic, score: 23 YP_001452692.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_001452693.1 Psort location: nuclear, score: 23 YP_001452694.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_001452695.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_001452696.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_001452697.1 COG: COG3141 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001452698.1 secreted protein; unknown function YP_001452699.1 COG: COG2979 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001452700.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues YP_001452701.1 3'-5' exonuclease activity on single or double-strand DNA YP_001452702.1 KEGG: psp:PSPPH_2956 8.3e-08 hydrolase, carbon-nitrogen family K01950; COG: COG0388 Predicted amidohydrolase; Psort location: cytoplasmic, score: 23 YP_001452703.1 KEGG: spt:SPA0993 1.7e-33 holE; DNA polymerase III, theta subunit K02345; COG: NOG13893 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452704.1 COG: COG2372 Uncharacterized protein, homolog of Cu resistance protein CopC; Psort location: extracellular, including cell wall, score: 9 YP_001452705.1 COG: COG1276 Putative copper export protein; Psort location: plasma membrane, score: 23 YP_001452706.1 COG: NOG09766 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001452707.1 Psort location: cytoskeletal, score: 9 YP_001452708.1 Psort location: cytoplasmic, score: 23 YP_001452709.1 COG: NOG34864 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001452710.1 Psort location: endoplasmic reticulum, score: 9 YP_001452711.1 IrgA-homologue adhesin (Iha); TonB-dependent; acts as a specific receptor of enterobactin; fur-regulated; urovirulence factor YP_001452712.1 Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins YP_001452713.1 COG: NOG12164 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452714.1 COG: NOG13883 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001452715.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA YP_001452716.1 COG: COG3008 Paraquat-inducible protein B; Psort location: endoplasmic reticulum, score: 9 YP_001452717.1 COG: COG2995 Uncharacterized paraquat-inducible protein A; Psort location: endoplasmic reticulum, score: 9 YP_001452718.1 COG: COG1956 GAF domain-containing protein; Psort location: cytoplasmic, score: 23 YP_001452719.1 affects solute and DNA transport through an unknown mechanism YP_001452720.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 YP_001452721.1 putative metalloprotease YP_001452722.1 KEGG: sgl:SG1466 2.8e-06 deTHIobiotin synthase K01935; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001452723.1 Psort location: cytoplasmic, score: 23 YP_001452724.1 COG: COG1414 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001452725.1 COG: NOG13884 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001452726.1 Psort location: nuclear, score: 23 YP_001452727.1 COG: NOG18120 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001452728.1 COG: NOG11327 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001452729.1 Psort location: mitochondrial, score: 23 YP_001452730.1 COG: COG1278 Cold shock proteins; Psort location: cytoplasmic, score: 23 YP_001452731.1 KEGG: ecc:c0102 1.8e-196 ftsI; peptidoglycan synthetase ftsI precursor K03587; COG: COG0768 Cell division protein FtsI/penicillin-binding protein 2; Psort location: endoplasmic reticulum, score: 9 YP_001452732.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth YP_001452733.1 COG: COG1971 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001452734.1 Psort location: cytoplasmic, score: 23 YP_001452735.1 COG: COG4811 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001452736.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel YP_001452737.1 KEGG: eci:UTI89_C2015 1.9e-128 manY; PTS enzyme IIC, mannose-specific K02795; COG: COG3715 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC; Psort location: endoplasmic reticulum, score: 9 YP_001452738.1 KEGG: stm:STM1830 1.2e-160 manX; Sugar Specific PTS family, mannose-specific enzyme IIAB K02793:K02794; COG: COG2893 Phosphotransferase system, mannose/fructose-specific component IIA; Psort location: cytoplasmic, score: 23 YP_001452739.1 Psort location: nuclear, score: 23 YP_001452740.1 KEGG: eci:UTI89_C0656 7.4e-24 ybeX; putative transport protein K06189; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: plasma membrane, score: 23 YP_001452741.1 KEGG: eci:UTI89_C1702 5.1e-33 hypothetical protein; COG: COG2200 FOG: EAL domain; Psort location: endoplasmic reticulum, score: 23 YP_001452742.1 Psort location: cytoplasmic, score: 23 YP_001452743.1 KEGG: stm:STM1826 2.7e-234 sdaA; L-serine deaminase I/L-threonine deaminase I K01752; COG: COG1760 L-serine deaminase; Psort location: cytoplasmic, score: 23 YP_001452744.1 KEGG: gbe:GbCGDNIH1_1634 1.2e-30 coA pyrophosphatase K01529; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001452745.1 KEGG: spt:SPA1049 1.2e-197 pabB; para-aminobenzoate synthase component I K01665; COG: COG0147 Anthranilate/para-aminobenzoate synthases component I; Psort location: cytoplasmic, score: 23 YP_001452746.1 COG: COG3140 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001452747.1 KEGG: mxa:MXAN_0920 0.00015 2-aminomuconate deaminase; COG: COG0251 Putative translation initiation inhibitor, yjgF family; Psort location: cytoskeletal, score: 9 YP_001452748.1 Psort location: mitochondrial, score: 23 YP_001452749.1 KEGG: sty:STY1951 0. putative ATP-dependent helicase K03722; COG: COG1199 Rad3-related DNA helicases; Psort location: cytoplasmic, score: 23 YP_001452750.1 KEGG: ecp:ECP_1750 1.3e-108 hypothetical protease YeaZ K01423; COG: COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone; Psort location: cytoplasmic, score: 23 YP_001452751.1 COG: COG3065 Starvation-inducible outer membrane lipoprotein; Psort location: endoplasmic reticulum, score: 9 YP_001452752.1 Psort location: cytoplasmic, score: 23 YP_001452753.1 KEGG: eci:UTI89_C1998 2.2e-184 rnd; ribonuclease D K03684; COG: COG0349 Ribonuclease D; Psort location: cytoplasmic, score: 23 YP_001452754.1 KEGG: ece:Z2843 4.8e-180 yeaU; putative tartrate dehydrogenase K07246:K00056:K07247; COG: COG0473 Isocitrate/isopropylmalate dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001452755.1 KEGG: shn:Shewana3_3435 7.6e-07 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001452756.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell YP_001452757.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums YP_001452758.1 blocks the formation of polar Z-ring septums YP_001452759.1 COG: COG3100 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001452760.1 KEGG: chu:CHU_1891 1.6e-39 ycgM; 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase, fumarylacetoacetate hydrolase family K01828; COG: COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway); Psort location: cytoplasmic, score: 23 YP_001452761.1 COG: COG2983 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001452762.1 COG: COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance; Psort location: mitochondrial, score: 23 YP_001452763.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein YP_001452764.1 involved in regulation of intracellular pH under alkaline conditions YP_001452765.1 Multifunctional regulator of fatty acid metabolism YP_001452766.1 Psort location: cytoplasmic, score: 23 YP_001452767.1 COG: COG2719 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001452768.1 Psort location: nuclear, score: 23 YP_001452769.1 catalyzes the oxidative deamination of D-amino acids YP_001452770.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA YP_001452771.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli YP_001452772.1 Psort location: mitochondrial, score: 23 YP_001452773.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine YP_001452774.1 KEGG: stm:STM1799 5.7e-97 emtA; membrane-bound lytic murein transglycosylase E K08308; COG: COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); Psort location: extracellular, including cell wall, score: 9 YP_001452775.1 COG: COG5581 Predicted glycosyltransferase; Psort location: cytoskeletal, score: 9 YP_001452776.1 KEGG: cjk:jk1171 0.00073 cdsA; phosphatidate cytidylyltransferase K00981; COG: COG2261 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001452777.1 Psort location: nuclear, score: 23 YP_001452778.1 COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: extracellular, including cell wall, score: 9 YP_001452779.1 COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: extracellular, including cell wall, score: 9 YP_001452780.1 involved in molybdenum transport YP_001452781.1 KEGG: sat:SYN_01050 2.7e-26 methyltransferase K00599; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001452782.1 KEGG: ecp:ECP_1242 8.0e-91 iron ABC transporter, ATP-binding protein K02013; COG: COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components; Psort location: mitochondrial, score: 23 YP_001452783.1 COG: COG0609 ABC-type Fe3+-siderophore transport system, permease component; Psort location: endoplasmic reticulum, score: 23 YP_001452784.1 COG: COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component; Psort location: mitochondrial, score: 23 YP_001452785.1 periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell YP_001452786.1 phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL YP_001452787.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone YP_001452788.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase YP_001452789.1 COG: NOG06782 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452790.1 COG: NOG26670 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001452791.1 Psort location: cytoplasmic, score: 23 YP_001452792.1 Psort location: mitochondrial, score: 23 YP_001452793.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: endoplasmic reticulum, score: 9 YP_001452794.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001452795.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: endoplasmic reticulum, score: 9 YP_001452796.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001452797.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001452798.1 Psort location: cytoplasmic, score: 23 YP_001452799.1 KEGG: shn:Shewana3_3435 9.4e-16 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001452800.1 Psort location: nuclear, score: 23 YP_001452801.1 KEGG: bur:Bcep18194_C6997 0. oxidoreductase alpha (molybdopterin) subunit K00122; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001452802.1 Psort location: mitochondrial, score: 23 YP_001452803.1 KEGG: sec:SC0401 1.5e-201 cydA; cytochrome BD2 subunit I K00425; COG: COG1271 Cytochrome bd-type quinol oxidase, subunit 1; Psort location: plasma membrane, score: 23 YP_001452804.1 KEGG: ppu:PP_4650 1.5e-130 cioB; ubiquinol oxidase subunit II, cyanide insensitive K00426; COG: COG1294 Cytochrome bd-type quinol oxidase, subunit 2; Psort location: plasma membrane, score: 23 YP_001452805.1 Psort location: nuclear, score: 23 YP_001452806.1 COG: NOG22122 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001452807.1 Psort location: mitochondrial, score: 23 YP_001452808.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_001452809.1 COG: COG3781 Predicted membrane protein; Psort location: cytoplasmic, score: 23 YP_001452810.1 KEGG: sru:SRU_1725 3.0e-59 lys1; saccharopine dehydrogenase K00290; COG: COG3268 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001452811.1 KEGG: aci:ACIAD1743 1.6e-108 putative oxydoreductase protein, zinc-containing (quinone oxidoreductase, NADPH dependent) K00345; COG: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001452812.1 KEGG: rpb:RPB_3810 0.00030 dTDP-glucose 4,6-dehydratase K01710; COG: NOG25890 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452813.1 KEGG: reh:H16_A2781 1.2e-09 predicted epimerase, PhzC/PhzF homolog; COG: COG0384 Predicted epimerase, PhzC/PhzF homolog; Psort location: cytoplasmic, score: 23 YP_001452814.1 KEGG: ece:Z3022 1.6e-67 yedL; hypothetical protein K03829; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001452815.1 KEGG: btk:BT9727_2749 1.2e-14 ribosomal-protein-alanine acetyltransferase K00676; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001452816.1 Psort location: cytoplasmic, score: 23 YP_001452817.1 COG: COG1636 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001452818.1 KEGG: bce:BC2020 1.3e-05 spermine/spermidine acetyltransferase K00657; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001452819.1 COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: extracellular, including cell wall, score: 9 YP_001452820.1 KEGG: yps:YPTB1592 7.4e-278 ybtE, irp5; yersiniabactin siderophore biosynthetic protein K04783; COG: COG1021 Peptide arylation enzymes; Psort location: cytoplasmic, score: 23 YP_001452821.1 KEGG: eci:UTI89_C2186 2.1e-138 ybtT; YbtT protein K05374; COG: COG3208 Predicted THIoesterase involved in non-ribosomal peptide biosynthesis; Psort location: extracellular, including cell wall, score: 9 YP_001452822.1 COG: COG4693 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis; Psort location: endoplasmic reticulum, score: 9 YP_001452823.1 KEGG: eci:UTI89_C2184 0. irp1; HMWP1 nonribosomal peptide/polyketide synthase K04786; COG: COG3319 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases; Psort location: cytoplasmic, score: 23 YP_001452824.1 KEGG: bur:Bcep18194_B0672 4.1e-190 non-ribosomal peptide synthetase modules K01776; COG: COG3433 Aryl carrier domain; Psort location: cytoplasmic, score: 23 YP_001452825.1 KEGG: bur:Bcep18194_C7173 1.1e-06 two component transcriptional regulator, AraC family; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: nuclear, score: 23 YP_001452826.1 KEGG: rru:Rru_A0864 2.5e-80 ABC transporter, transmembrane region K06020; COG: COG1132 ABC-type multidrug transport system, ATPase and permease components; Psort location: endoplasmic reticulum, score: 9 YP_001452827.1 KEGG: pen:PSEEN2497 1.0e-81 ABC transporter, permease/ATP-binding protein; COG: COG1132 ABC-type multidrug transport system, ATPase and permease components; Psort location: endoplasmic reticulum, score: 9 YP_001452828.1 KEGG: eci:UTI89_C0457 6.2e-19 ampG; AmpG muropeptide MFS transporter K08218; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001452829.1 catalyzes the conversion of chorismate to salicylate in the biosynthesis of the siderophore yersiniabactin YP_001452830.1 Psort location: nuclear, score: 23 YP_001452831.1 Psort location: cytoplasmic, score: 23 YP_001452832.1 Psort location: nuclear, score: 23 YP_001452833.1 COG: NOG20166 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452834.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001452835.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001452836.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function YP_001452837.1 KEGG: rpb:RPB_1201 7.7e-54 cytochrome b/c1 K00413:K00412; COG: COG1290 Cytochrome b subunit of the bc complex; Psort location: endoplasmic reticulum, score: 9 YP_001452838.1 KEGG: rpc:RPC_0925 3.3e-85 cytochrome c1 K00413; COG: COG1290 Cytochrome b subunit of the bc complex; Psort location: endoplasmic reticulum, score: 9 YP_001452839.1 KEGG: rpc:RPC_1923 7.5e-40 ubiquinol-cytochrome c reductase, iron-sulfur subunit K00411; COG: COG0723 Rieske Fe-S protein; Psort location: cytoplasmic, score: 23 YP_001452840.1 COG: COG3794 Plastocyanin; Psort location: extracellular, including cell wall, score: 9 YP_001452841.1 KEGG: bmf:BAB2_0485 8.9e-76 ATP/GTP-binding site motif A (P-loop):ABC transporter:AAA ATPase K02013; COG: COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components; Psort location: mitochondrial, score: 23 YP_001452842.1 COG: COG0609 ABC-type Fe3+-siderophore transport system, permease component; Psort location: plasma membrane, score: 23 YP_001452843.1 COG: COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component; Psort location: cytoplasmic, score: 23 YP_001452844.1 Psort location: cytoplasmic, score: 23 YP_001452845.1 KEGG: spz:M5005_Spy_1700 1.2e-06 acetyltransferase K00680; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001452846.1 putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport YP_001452847.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_001452848.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_001452849.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein YP_001452850.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_001452851.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001452852.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB YP_001452853.1 COG: COG3094 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001452854.1 COG: COG2912 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001452855.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_001452856.1 COG: COG0387 Ca2+/H+ antiporter; Psort location: plasma membrane, score: 23 YP_001452857.1 Psort location: mitochondrial, score: 23 YP_001452858.1 in Escherichia coli this protein putatively regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions YP_001452859.1 COG: COG3703 Uncharacterized protein involved in cation transport; Psort location: cytoplasmic, score: 23 YP_001452860.1 Psort location: cytoplasmic, score: 23 YP_001452861.1 Psort location: endoplasmic reticulum, score: 9 YP_001452862.1 Psort location: cytoplasmic, score: 23 YP_001452863.1 KEGG: sme:SMc00339 2.5e-06 cyaA; adenylate cyclase 1 protein K01768; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001452864.1 COG: COG1553 Uncharacterized conserved protein involved in intracellular sulfur reduction; Psort location: extracellular, including cell wall, score: 9 YP_001452865.1 KEGG: xac:XAC2157 0.0030 cysG; uroporphyrin-III C-methyltransferase K02302; COG: COG3707 Response regulator with putative antiterminator output domain; Psort location: cytoplasmic, score: 23 YP_001452866.1 COG: COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components; Psort location: endoplasmic reticulum, score: 9 YP_001452867.1 KEGG: rha:RHA1_ro08170 7.7e-22 ABC transporter, permease component; COG: COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001452868.1 KEGG: azo:azo0944 4.0e-89 nasD; putative nitrate transport system, ATP-binding protein; COG: COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001452869.1 KEGG: eca:ECA2991 0. nasB; nitrite reductase [NAD(P)H] large subunit K00362; COG: COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases; Psort location: mitochondrial, score: 23 YP_001452870.1 KEGG: eca:ECA2990 1.7e-264 nasA; nitrate reductase K00372; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: mitochondrial, score: 23 YP_001452871.1 COG: NOG06760 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452872.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase YP_001452873.1 KEGG: sec:SC1760 1.1e-292 narX; sensory histidine kinase in two component regulatory system with NarL, senses nitrate/nitrite, regulates anaerobic respiration and fermentation K07673; COG: COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific; Psort location: endoplasmic reticulum, score: 9 YP_001452874.1 Psort location: cytoplasmic, score: 23 YP_001452875.1 COG: COG2223 Nitrate/nitrite transporter; Psort location: endoplasmic reticulum, score: 9 YP_001452876.1 Psort location: endoplasmic reticulum, score: 9 YP_001452877.1 KEGG: spt:SPA1109 0. narG; respiratory nitrate reductase 1 alpha chain K00370; COG: COG5013 Nitrate reductase alpha subunit; Psort location: cytoplasmic, score: 23 YP_001452878.1 KEGG: stt:t1672 2.2e-285 narH; respiratory nitrate reductase 1 beta chain K00371; COG: COG1140 Nitrate reductase beta subunit; Psort location: cytoplasmic, score: 23 YP_001452879.1 KEGG: spt:SPA1111 1.0e-115 narJ; respiratory nitrate reductase 1 delta chain K00373; COG: COG2180 Nitrate reductase delta subunit; Psort location: cytoplasmic, score: 23 YP_001452880.1 KEGG: stm:STM1761 1.0e-115 narI; nitrate reductase gamma chain K00374; COG: COG2181 Nitrate reductase gamma subunit; Psort location: plasma membrane, score: 23 YP_001452881.1 Psort location: cytoplasmic, score: 23 YP_001452882.1 Psort location: cytoplasmic, score: 23 YP_001452883.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_001452884.1 KEGG: pen:PSEEN4477 0.0058 secA; preprotein translocase SecA subunit; COG: COG3012 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001452885.1 KEGG: eci:UTI89_C1430 3.3e-140 ychK; hypothetical protein; COG: COG1752 Predicted esterase of the alpha-beta hydrolase superfamily; Psort location: cytoplasmic, score: 23 YP_001452886.1 KEGG: eci:UTI89_C1431 1.2e-165 rssB; RssB/Hnr protein K02485; COG: COG0784 FOG: CheY-like receiver; Psort location: cytoplasmic, score: 23 YP_001452887.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose YP_001452888.1 Psort location: mitochondrial, score: 23 YP_001452889.1 COG: COG2916 DNA-binding protein H-NS; Psort location: nuclear, score: 23 YP_001452890.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_001452891.1 KEGG: stm:STM1749 0. adhE; alcohol dehydrogenase / acetaldehyde dehydrogenase K00001:K04072; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001452892.1 COG: COG2095 Multiple antibiotic transporter; Psort location: plasma membrane, score: 23 YP_001452893.1 KEGG: shn:Shewana3_2650 2.4e-20 acetate kinase K00925; COG: COG4166 ABC-type oligopeptide transport system, periplasmic component; Psort location: endoplasmic reticulum, score: 9 YP_001452894.1 KEGG: rha:RHA1_ro09047 8.1e-43 ABC peptide transporter, permease component K02033; COG: COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001452895.1 KEGG: baa:BA_0884 0.00079 binding-protein-dependent transport systems inner membrane component K00294; COG: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001452896.1 KEGG: rru:Rru_A0589 9.3e-97 oligopeptide/dipeptide ABC transporter, ATP-binding protein-like K02031; COG: COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001452897.1 KEGG: bur:Bcep18194_B0119 3.6e-95 oligopeptide/dipeptide ABC transporter, ATPase subunit K02032; COG: COG4608 ABC-type oligopeptide transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001452898.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein YP_001452899.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol) YP_001452900.1 Psort location: mitochondrial, score: 23 YP_001452901.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_001452902.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins YP_001452903.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins YP_001452904.1 Involved in cell division; probably involved in intracellular septation YP_001452905.1 COG: NOG06197 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001452906.1 receptor for colicin S4 YP_001452907.1 Psort location: cytoplasmic, score: 23 YP_001452908.1 KEGG: bpm:BURPS1710b_A1493 3.0e-12 GGDEF domain protein; COG: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001452909.1 KEGG: ecc:c1725 1.8e-123 trpA; tryptophan synthase alpha chain K01695; COG: COG0159 Tryptophan synthase alpha chain; Psort location: cytoplasmic, score: 23 YP_001452910.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001452911.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate YP_001452912.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis YP_001452913.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_001452914.1 KEGG: reh:H16_A1200 1.4e-40 predicted metal-dependent phosphoesterase (PHP family); COG: COG0613 Predicted metal-dependent phosphoesterases (PHP family); Psort location: cytoplasmic, score: 23 YP_001452915.1 COG: COG0009 Putative translation factor (SUA5); Psort location: cytoplasmic, score: 23 YP_001452916.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA YP_001452917.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide YP_001452918.1 KEGG: eco:b1271 4.1e-119 yciK; short chain dehydrogenase K00100; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001452919.1 Psort location: mitochondrial, score: 23 YP_001452920.1 SohB; periplasmic protein; member of the peptidase S49 family YP_001452921.1 Psort location: nuclear, score: 23 YP_001452922.1 Psort location: cytoplasmic, score: 23 YP_001452923.1 COG: NOG13548 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452924.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_001452925.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation YP_001452926.1 Psort location: mitochondrial, score: 23 YP_001452927.1 COG: NOG13876 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001452928.1 Psort location: cytoplasmic, score: 23 YP_001452929.1 Psort location: mitochondrial, score: 23 YP_001452930.1 Psort location: nuclear, score: 23 YP_001452931.1 Catalyzes the conversion of citrate to isocitrate YP_001452932.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate YP_001452933.1 Psort location: endoplasmic reticulum, score: 9 YP_001452934.1 KEGG: sty:STY1341 3.7e-125 pgpB; phosphatidylglycerophosphatase B K01096; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001452935.1 Psort location: cytoplasmic, score: 23 YP_001452936.1 COG: COG3771 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001452937.1 KEGG: azo:azo1075 1.9e-59 conserved hypothetical transferase protein; COG: COG2956 Predicted N-acetylglucosaminyl transferase; Psort location: cytoplasmic, score: 23 YP_001452938.1 KEGG: ecc:c1750 1.0e-122 pyrF; orotidine 5'-phosphate decarboxylase K01591; COG: COG0284 Orotidine-5-phosphate decarboxylase; Psort location: cytoplasmic, score: 23 YP_001452939.1 involved in start site selection during the initiation of translation YP_001452940.1 COG: NOG17005 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001452941.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001452942.1 COG: NOG34196 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452943.1 Psort location: nuclear, score: 23 YP_001452944.1 c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP YP_001452945.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction YP_001452946.1 COG: COG2128 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001452947.1 Psort location: nuclear, score: 23 YP_001452948.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_001452949.1 COG: COG3204 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001452950.1 KEGG: bur:Bcep18194_A6388 7.9e-52 oligopeptide/dipeptide ABC transporter, ATPase subunit K02032; COG: COG4167 ABC-type antimicrobial peptide transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001452951.1 KEGG: rru:Rru_A2359 5.6e-67 oligopeptide/dipeptide ABC transporter, ATP-binding protein-like K06020; COG: COG4170 ABC-type antimicrobial peptide transport system, ATPase component; Psort location: nuclear, score: 23 YP_001452952.1 KEGG: lwe:lwe0999 0.00049 gbuB; glycine betaine/L-proline ABC transporter, permease protein; COG: COG4171 ABC-type antimicrobial peptide transport system, permease component; Psort location: endoplasmic reticulum, score: 23 YP_001452953.1 KEGG: syf:Synpcc7942_2454 2.1e-28 adenine phosphoribosyltransferase K00759; COG: COG4168 ABC-type antimicrobial peptide transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001452954.1 KEGG: shn:Shewana3_2650 2.2e-120 acetate kinase K00925; COG: COG4166 ABC-type oligopeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001452955.1 Psort location: extracellular, including cell wall, score: 9 YP_001452956.1 Psort location: cytoplasmic, score: 23 YP_001452957.1 Psort location: cytoplasmic, score: 23 YP_001452958.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor YP_001452959.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF YP_001452960.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding YP_001452961.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock YP_001452962.1 COG: NOG14121 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452963.1 KEGG: eci:UTI89_C1592 1.3e-243 ycjX; hypothetical protein YcjX; COG: COG3106 Predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001452964.1 COG: COG3768 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 23 YP_001452965.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids YP_001452966.1 KEGG: eci:UTI89_C3355 0.00015 nupG; transport of nucleosides, permease protein K03289; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001452967.1 Psort location: cytoplasmic, score: 23 YP_001452968.1 COG: NOG06222 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001452969.1 KEGG: bcz:BCZK3497 1.2e-11 adaA; transcriptional regulator, AraC family K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001452970.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein YP_001452971.1 Psort location: cytoplasmic, score: 23 YP_001452972.1 KEGG: sdy:SDY_1403 7.8e-148 ycjG; putative muconate cycloisomerase I; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: cytoplasmic, score: 23 YP_001452973.1 COG: COG2866 Predicted carboxypeptidase; Psort location: cytoplasmic, score: 23 YP_001452974.1 KEGG: shn:Shewana3_2650 1.1e-20 acetate kinase K00925; COG: COG4166 ABC-type oligopeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001452975.1 COG: COG0668 Small-conductance mechanosensitive channel; Psort location: endoplasmic reticulum, score: 9 YP_001452976.1 COG: NOG14120 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001452977.1 with UspC and UspD is involved in resistance to UV irradiation YP_001452978.1 Psort location: nuclear, score: 23 YP_001452979.1 Psort location: mitochondrial, score: 23 YP_001452980.1 Psort location: nuclear, score: 23 YP_001452981.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia YP_001452982.1 KEGG: sdy:SDY_1416 5.6e-83 ogt; O-6-alkylguanine-DNA/cysteine-protein methyltransferase K00567; COG: COG0350 Methylated DNA-protein cysteine methyltransferase; Psort location: cytoskeletal, score: 9 YP_001452983.1 Psort location: endoplasmic reticulum, score: 9 YP_001452984.1 COG: COG2840 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001452985.1 KEGG: eci:UTI89_C1612 1.9e-167 ydaM; hypothetical protein YdaM; COG: COG2199 FOG: GGDEF domain; Psort location: cytoplasmic, score: 23 YP_001452986.1 Psort location: nuclear, score: 23 YP_001452987.1 COG: COG0598 Mg2+ and Co2+ transporters; Psort location: cytoplasmic, score: 23 YP_001452988.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA YP_001452989.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_001452990.1 Psort location: mitochondrial, score: 23 YP_001452991.1 COG: COG0589 Universal stress protein UspA and related nucleotide-binding proteins; Psort location: cytoplasmic, score: 23 YP_001452992.1 COG: NOG22391 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001452993.1 Psort location: mitochondrial, score: 23 YP_001452994.1 COG: COG3203 Outer membrane protein (porin); Psort location: extracellular, including cell wall, score: 9 YP_001452995.1 KEGG: ecp:ECP_1403 0. probable pyruvate-flavodoxin oxidoreductase K03737; COG: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit; Psort location: cytoplasmic, score: 23 YP_001452996.1 Psort location: cytoplasmic, score: 23 YP_001452997.1 COG: COG3042 Putative hemolysin; Psort location: extracellular, including cell wall, score: 9 YP_001452998.1 KEGG: pmu:PM0180 0.0081 murZ; UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790; COG: COG3187 Heat shock protein; Psort location: extracellular, including cell wall, score: 9 YP_001452999.1 KEGG: spt:SPA1239 2.2e-168 ldhA; D-lactate dehydrogenase K03778; COG: COG1052 Lactate dehydrogenase and related dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001453000.1 Psort location: cytoplasmic, score: 23 YP_001453001.1 Psort location: cytoplasmic, score: 23 YP_001453002.1 KEGG: cal:orf19.2410 3.8e-05 IMH1; involved in vesicular transport K01553; COG: COG5295 Autotransporter adhesin; Psort location: extracellular, including cell wall, score: 9 YP_001453003.1 Psort location: cytoplasmic, score: 23 YP_001453004.1 COG: COG3059 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 23 YP_001453005.1 COG: NOG06225 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001453006.1 COG: NOG17319 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001453007.1 COG: COG3784 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001453008.1 KEGG: eco:b1406 1.7e-127 ydbC; predicted oxidoreductase, NAD(P)-binding; COG: COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001453009.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds YP_001453010.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain YP_001453011.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001453012.1 COG: COG1280 Putative threonine efflux protein; Psort location: endoplasmic reticulum, score: 9 YP_001453013.1 COG: COG1538 Outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001453014.1 COG: COG1566 Multidrug resistance efflux pump; Psort location: cytoplasmic, score: 23 YP_001453015.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001453016.1 Psort location: cytoplasmic, score: 23 YP_001453017.1 COG: COG1434 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001453018.1 NAD-linked YP_001453019.1 KEGG: eca:ECA2408 9.0e-99 paeX; pectin acetylesterase; COG: COG0657 Esterase/lipase; Psort location: cytoplasmic, score: 23 YP_001453020.1 KEGG: ssn:SSO_1725 1.5e-160 gapC; glyceraldehyde-3-phosphate dehydrogenase K00134; COG: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001453021.1 Psort location: nuclear, score: 23 YP_001453022.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm YP_001453023.1 COG: COG1937 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001453024.1 KEGG: stm:STM1627 7.5e-198 alcohol dehydrogenase class III K00001:K00121; COG: COG1062 Zn-dependent alcohol dehydrogenases, class III; Psort location: cytoplasmic, score: 23 YP_001453025.1 KEGG: bxe:Bxe_C0521 6.9e-05 multi sensor hybrid histidine kinase; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001453026.1 KEGG: shn:Shewana3_3435 4.1e-05 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001453027.1 KEGG: vch:VC1687 3.4e-60 inorganic pyrophosphatase K01507; COG: COG1227 Inorganic pyrophosphatase/exopolyphosphatase; Psort location: cytoplasmic, score: 23 YP_001453028.1 COG: COG5383 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001453029.1 KEGG: stm:STM1623 3.9e-240 putative carboxylesterase K03927; COG: COG2272 Carboxylesterase type B; Psort location: cytoplasmic, score: 23 YP_001453030.1 Psort location: cytoplasmic, score: 23 YP_001453031.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans YP_001453032.1 COG: COG2841 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001453033.1 KEGG: sbo:SBO_1660 1.8e-70 rimL; acetyl transferase K03817; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001453034.1 KEGG: bfl:Bfl281 6.5e-05 lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase K02536; COG: NOG06285 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453035.1 COG: COG1275 Tellurite resistance protein and related permeases; Psort location: plasma membrane, score: 23 YP_001453036.1 with TehA confers resistance to tellurite YP_001453037.1 COG: NOG06284 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001453038.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001453039.1 KEGG: bli:BL05281 2.6e-14 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001453040.1 KEGG: pol:Bpro_0919 0.0021 NADH dehydrogenase (quinone) K05903; COG: COG3135 Uncharacterized protein involved in benzoate metabolism; Psort location: plasma membrane, score: 23 YP_001453041.1 KEGG: mmo:MMOB3450 0.0020 dam; adenine-specific DNA methyltransferase K06223; COG: COG1396 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001453042.1 KEGG: eco:b1435 0. ydcP; putative protease K08303; COG: COG0826 Collagenase and related proteases; Psort location: mitochondrial, score: 23 YP_001453043.1 Psort location: cytoplasmic, score: 23 YP_001453044.1 COG: NOG34613 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001453045.1 COG: COG1598 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001453046.1 KEGG: eci:UTI89_C1658 5.5e-218 ydcR; hypothetical protein YdcR K00811; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: cytoplasmic, score: 23 YP_001453047.1 Psort location: mitochondrial, score: 23 YP_001453048.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation YP_001453049.1 Psort location: nuclear, score: 23 YP_001453050.1 COG: NOG12162 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453051.1 Psort location: mitochondrial, score: 23 YP_001453052.1 COG: COG4458 Uncharacterized protein conserved in bacteria, putative virulence factor; Psort location: extracellular, including cell wall, score: 9 YP_001453053.1 COG: COG4457 Uncharacterized protein conserved in bacteria, putative virulence factor; Psort location: cytoplasmic, score: 23 YP_001453054.1 KEGG: mag:amb3277 9.8e-09 RTX toxins and related Ca2+-binding protein K00754; COG: NOG35976 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001453055.1 KEGG: shn:Shewana3_2650 4.7e-118 acetate kinase K00925; COG: COG0747 ABC-type dipeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001453056.1 COG: NOG13890 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001453057.1 Psort location: nuclear, score: 23 YP_001453058.1 COG: COG3238 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001453059.1 KEGG: ecj:JW5233 8.2e-82 yncA; predicted acyltransferase with acyl-CoA N-acyltransferase domain K03823; COG: COG1247 Sortase and related acyltransferases; Psort location: cytoplasmic, score: 23 YP_001453060.1 KEGG: psp:PSPPH_2917 3.1e-09 DNA-binding protein K00517; COG: COG1396 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001453061.1 KEGG: spt:SPA1279 3.0e-171 yncB; putative NADP-dependent oxidoreductase; COG: COG2130 Putative NADP-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001453062.1 COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: extracellular, including cell wall, score: 9 YP_001453063.1 COG: COG3391 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001453064.1 KEGG: eci:UTI89_C0120 2.0e-85 aroP; aromatic amino acid transport protein AroP K03293; COG: COG1113 Gamma-aminobutyrate permease and related permeases; Psort location: plasma membrane, score: 23 YP_001453065.1 KEGG: ecs:ECs2058 1.1e-91 putative transferase K00799; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001453066.1 KEGG: aha:AHA_1274 1.8e-29 response regulator PleD (stalked cell differentiation-controllingprotein) K05345; COG: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001453067.1 COG: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family; Psort location: cytoplasmic, score: 23 YP_001453068.1 KEGG: ecc:c1895 5.5e-131 nhoA; N-hydroxyarylamine O-acetyltransferase K00675; COG: COG2162 Arylamine N-acetyltransferase; Psort location: cytoplasmic, score: 23 YP_001453069.1 KEGG: eci:UTI89_C1683 3.1e-114 narV; respiratory nitrate reductase 2 gamma chain K08347; COG: COG2181 Nitrate reductase gamma subunit; Psort location: endoplasmic reticulum, score: 9 YP_001453070.1 KEGG: sty:STY1486 8.9e-108 narW; respiratory nitrate reductase 2 delta chain K08361; COG: COG2180 Nitrate reductase delta subunit; Psort location: cytoplasmic, score: 23 YP_001453071.1 KEGG: spt:SPA1290 3.7e-283 narY; respiratory nitrate reductase 2 beta chain K08346; COG: COG1140 Nitrate reductase beta subunit; Psort location: cytoplasmic, score: 23 YP_001453072.1 KEGG: stm:STM1577 0. narZ; nitrate reductase alpha chain K08345; COG: COG5013 Nitrate reductase alpha subunit; Psort location: cytoplasmic, score: 23 YP_001453073.1 COG: COG2223 Nitrate/nitrite transporter; Psort location: plasma membrane, score: 23 YP_001453074.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001453075.1 KEGG: gox:GOX0312 6.5e-05 NAD(P) transhydrogenase subunit beta K00325; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001453076.1 COG: COG3791 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001453077.1 COG: COG3203 Outer membrane protein (porin); Psort location: extracellular, including cell wall, score: 9 YP_001453078.1 Psort location: cytoplasmic, score: 23 YP_001453079.1 Psort location: nuclear, score: 23 YP_001453080.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001453081.1 Psort location: mitochondrial, score: 23 YP_001453082.1 KEGG: stm:STM1569 1.6e-163 fdnH; formate dehydrogenase, iron-sulfur subunit (formate dehydrogenase beta subunit) K08349; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: cytoplasmic, score: 23 YP_001453083.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase YP_001453084.1 Psort location: cytoplasmic, score: 23 YP_001453085.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_001453086.1 Psort location: mitochondrial, score: 23 YP_001453087.1 KEGG: pfl:PFL_0043 2.4e-43 osmC; hydroperoxide resistance protein OsmC K04063; COG: COG1764 Predicted redox protein, regulator of disulfide bond formation; Psort location: cytoplasmic, score: 23 YP_001453088.1 KEGG: reh:H16_A1304 3.2e-64 ABC-type transporter, ATPase component: PepT family; COG: COG1124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001453089.1 KEGG: reh:H16_B1125 2.3e-70 ABC-type transporter, ATPase component: PepT family; COG: COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001453090.1 COG: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001453091.1 KEGG: rha:RHA1_ro09047 1.3e-42 ABC peptide transporter, permease component K02033; COG: COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001453092.1 KEGG: shn:Shewana3_2650 1.0e-35 acetate kinase K00925; COG: COG0747 ABC-type dipeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001453093.1 catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis YP_001453094.1 KEGG: bam:Bamb_0825 0.0062 glucokinase K00845; COG: COG1737 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001453095.1 Psort location: extracellular, including cell wall, score: 9 YP_001453096.1 Psort location: cytoplasmic, score: 23 YP_001453097.1 KEGG: vfi:VFA0360 4.3e-16 sensory transduction protein kinase; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 23 YP_001453098.1 KEGG: psp:PSPPH_2917 0.0052 DNA-binding protein K00517; COG: NOG18342 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453099.1 COG: COG3550 Uncharacterized protein related to capsule biosynthesis enzymes; Psort location: cytoplasmic, score: 23 YP_001453100.1 KEGG: eci:UTI89_C1705 4.4e-170 yddW; hypothetical lipoprotein YddW precursor K01189; COG: COG1649 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001453101.1 KEGG: btk:BT9727_3510 1.7e-10 mutS; DNA mismatch repair protein K03555; COG: COG0249 Mismatch repair ATPase (MutS family); Psort location: endoplasmic reticulum, score: 9 YP_001453102.1 KEGG: btk:BT9727_3510 3.6e-10 mutS; DNA mismatch repair protein K03555; COG: COG0249 Mismatch repair ATPase (MutS family); Psort location: cytoplasmic, score: 23 YP_001453103.1 KEGG: mhu:Mhun_1018 6.0e-141 phosphopyruvate hydratase K01689; COG: COG0148 Enolase; Psort location: cytoplasmic, score: 23 YP_001453104.1 COG: COG0589 Universal stress protein UspA and related nucleotide-binding proteins; Psort location: cytoplasmic, score: 23 YP_001453105.1 COG: COG0561 Predicted hydrolases of the HAD superfamily; Psort location: cytoplasmic, score: 23 YP_001453106.1 KEGG: btl:BALH_1861 5.7e-10 acetyltransferase, GNAT family K00680; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001453107.1 KEGG: bme:BMEII0002 7.2e-35 ribosomal-protein-serine acetyltransferase K00680; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001453108.1 COG: COG3791 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001453109.1 catalyzes the formation of D-tagaturonate from D-altronate YP_001453110.1 COG: NOG13916 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001453111.1 catalyzes the formation of glutamate from glutamine YP_001453112.1 KEGG: rpc:RPC_2579 0.00023 multi-sensor signal transduction histidine kinase; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 23 YP_001453113.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase YP_001453114.1 KEGG: shn:Shewana3_3435 1.2e-09 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001453115.1 KEGG: lwe:lwe1547 2.2e-113 ldhB; L-lactate dehydrogenase K00016; COG: COG0039 Malate/lactate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001453116.1 KEGG: shn:Shewana3_1692 0.00024 Xaa-His dipeptidase K01270; COG: COG2814 Arabinose efflux permease; Psort location: plasma membrane, score: 23 YP_001453117.1 Psort location: cytoplasmic, score: 23 YP_001453118.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function YP_001453119.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes YP_001453120.1 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF YP_001453121.1 Psort location: cytoplasmic, score: 23 YP_001453122.1 COG: NOG15370 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001453123.1 KEGG: pae:PA1977 2.1e-05 sensor protein GLPS; COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001453124.1 Psort location: mitochondrial, score: 23 YP_001453125.1 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters YP_001453126.1 KEGG: pen:PSEEN4892 1.4e-95 branched-chain amino acid ABC transporter, ATP-binding protein; COG: COG0410 ABC-type branched-chain amino acid transport systems, ATPase component; Psort location: cytoplasmic, score: 23 YP_001453127.1 KEGG: pen:PSEEN4891 6.1e-93 branched-chain amino acid transport ABC transporter, ATP-binding component; COG: COG4674 Uncharacterized ABC-type transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001453128.1 KEGG: reh:H16_A3653 1.1e-14 ABC-type transporter, ATPase and permease components; COG: COG4177 ABC-type branched-chain amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001453129.1 KEGG: fal:FRAAL3359 1.8e-13 putative sulfate-transporting ATPase K06020; COG: COG0559 Branched-chain amino acid ABC-type transport system, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001453130.1 COG: COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component; Psort location: mitochondrial, score: 23 YP_001453131.1 catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate YP_001453132.1 Psort location: cytoplasmic, score: 23 YP_001453133.1 KEGG: bpm:BURPS1710b_A1493 1.8e-20 GGDEF domain protein; COG: COG2199 FOG: GGDEF domain; Psort location: cytoplasmic, score: 23 YP_001453134.1 KEGG: pab:PAB0087 2.5e-23 pbp; related beta-lactamase precursor K01467; COG: COG1680 Beta-lactamase class C and other penicillin binding proteins; Psort location: extracellular, including cell wall, score: 9 YP_001453135.1 Psort location: extracellular, including cell wall, score: 9 YP_001453136.1 KEGG: spt:SPA1343 0. dcp; dipeptidyl carboxypeptidase II K01284; COG: COG0339 Zn-dependent oligopeptidases; Psort location: cytoplasmic, score: 23 YP_001453137.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine YP_001453138.1 KEGG: msm:MSMEG_3400 1.9e-07 glutamyl-tRNA(Gln) amidotransferase subunit A K01957; COG: COG1802 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001453139.1 Psort location: mitochondrial, score: 23 YP_001453140.1 KEGG: ecc:c1968 1.7e-223 ydfI; hypothetical oxidoreductase YdfI; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001453141.1 KEGG: cal:orf19.2425 3.7e-05 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001453142.1 KEGG: stm:STM1506 7.5e-159 rspB; putative dehydrogenase K08322; COG: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001453143.1 KEGG: eci:UTI89_C1768 8.7e-220 rspA; starvation sensing protein RspA K08323; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: cytoplasmic, score: 23 YP_001453144.1 KEGG: rpd:RPD_0676 0.00065 NADH dehydrogenase (quinone) K05903; COG: COG1742 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 23 YP_001453145.1 COG: NOG11441 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001453146.1 KEGG: sec:SC1519 1.5e-91 speG; spermidine N1-acetyltransferase K00657; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001453147.1 COG: NOG06202 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001453148.1 KEGG: spi:MGAS10750_Spy0938 0.0084 gabD; succinate-semialdehyde dehydrogenase (NADP+) K00135; COG: NOG12175 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001453149.1 KEGG: stm:STM1499 0. putative dimethyl sulphoxide reductase, chain A1 K07309; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001453150.1 KEGG: stm:STM1498 0. putative dimethyl sulphoxide reductase K07310; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: mitochondrial, score: 23 YP_001453151.1 KEGG: ecp:ECP_0909 2.4e-114 anaerobic dimethyl sulfoxide reductase, subunit B K07307; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: cytoplasmic, score: 23 YP_001453152.1 KEGG: eci:UTI89_C1777 2.8e-127 ynfH; anaerobic dimethyl sulfoxide reductase chain YnfH K07312; COG: COG3302 DMSO reductase anchor subunit; Psort location: plasma membrane, score: 23 YP_001453153.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane YP_001453154.1 KEGG: lwe:lwe1439 2.0e-39 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1174 ABC-type proline/glycine betaine transport systems, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001453155.1 KEGG: lwe:lwe1443 2.0e-32 opuCC; glycine betaine/L-proline ABC transporter, glycine betaine/L-proline-binding protein; COG: COG1732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein); Psort location: extracellular, including cell wall, score: 9 YP_001453156.1 KEGG: lwe:lwe1439 2.7e-42 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1174 ABC-type proline/glycine betaine transport systems, permease component; Psort location: plasma membrane, score: 23 YP_001453157.1 KEGG: bur:Bcep18194_C7553 6.1e-132 ABC glycine betaine/L-proline transporter, ATPase subunit K05847; COG: COG1125 ABC-type proline/glycine betaine transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001453158.1 Psort location: cytoplasmic, score: 23 YP_001453159.1 KEGG: cpr:CPR_1400 1.5e-23 chloride channel protein K01529; COG: COG0038 Chloride channel protein EriC; Psort location: plasma membrane, score: 23 YP_001453160.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_001453161.1 KEGG: eci:UTI89_C1781 5.3e-197 mlc; putative NAGC-like transcriptional regulator K00845; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: cytoplasmic, score: 23 YP_001453162.1 Psort location: nuclear, score: 23 YP_001453163.1 KEGG: shn:Shewana3_3435 5.3e-23 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: endoplasmic reticulum, score: 9 YP_001453164.1 KEGG: shn:Shewana3_1692 3.5e-49 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001453165.1 Psort location: mitochondrial, score: 23 YP_001453166.1 Psort location: cytoplasmic, score: 23 YP_001453167.1 COG: COG1266 Predicted metal-dependent membrane protease; Psort location: endoplasmic reticulum, score: 23 YP_001453168.1 KEGG: yps:YPTB2232 3.5e-184 putative carboxypeptidase K01299; COG: COG2317 Zn-dependent carboxypeptidase; Psort location: cytoplasmic, score: 23 YP_001453169.1 COG: NOG18699 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001453170.1 Psort location: mitochondrial, score: 23 YP_001453171.1 Psort location: mitochondrial, score: 23 YP_001453172.1 KEGG: sty:STY1583 2.7e-129 putative secreted protein K04775; COG: COG3591 V8-like Glu-specific endopeptidase; Psort location: extracellular, including cell wall, score: 9 YP_001453173.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS YP_001453174.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS YP_001453175.1 Psort location: cytoplasmic, score: 23 YP_001453176.1 Psort location: nuclear, score: 23 YP_001453177.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes YP_001453178.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme YP_001453179.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_001453180.1 Psort location: cytoplasmic, score: 23 YP_001453181.1 COG: NOG06063 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001453182.1 KEGG: eci:UTI89_C0120 2.1e-09 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001453183.1 Psort location: mitochondrial, score: 23 YP_001453184.1 KEGG: sdy:SDY_1547 1.0e-115 ydgB; putative oxidoreductase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001453185.1 COG: COG3136 Uncharacterized membrane protein required for alginate biosynthesis; Psort location: endoplasmic reticulum, score: 9 YP_001453186.1 response regulator in two-component regulatory system with RstB YP_001453187.1 KEGG: spt:SPA1384 1.1e-203 rstB; two component sensor kinase K07639; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001453188.1 binds to DNA replication terminator sequences to prevent passage of replication forks YP_001453189.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001453190.1 KEGG: eci:UTI89_C1800 1.0e-289 fumA; fumarase A K01676; COG: COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain; Psort location: cytoplasmic, score: 23 YP_001453191.1 Psort location: cytoplasmic, score: 23 YP_001453192.1 KEGG: stm:STM1467 5.6e-186 manA; mannose-6-phosphate isomerase K01809; COG: COG1482 Phosphomannose isomerase; Psort location: cytoplasmic, score: 23 YP_001453193.1 COG: COG5339 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001453194.1 regulates malXY which are involved in maltose-glucose transport YP_001453195.1 Psort location: cytoplasmic, score: 23 YP_001453196.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site YP_001453197.1 KEGG: ece:Z2627 6.4e-185 malY; enzyme that may degrade or block biosynthesis of endogenous mal inducer, probably aminotrasferase K01760; COG: COG1168 Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities; Psort location: cytoplasmic, score: 23 YP_001453198.1 catalyzes the formation of inosine from adenosine YP_001453199.1 KEGG: eci:UTI89_C1812 7.5e-182 ydgJ; hypothetical oxidoreductase YdgJ; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001453200.1 Psort location: endoplasmic reticulum, score: 9 YP_001453201.1 Psort location: nuclear, score: 23 YP_001453202.1 Psort location: nuclear, score: 23 YP_001453203.1 Psort location: cytoplasmic, score: 23 YP_001453204.1 Psort location: mitochondrial, score: 23 YP_001453205.1 COG: NOG13887 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453206.1 COG: NOG08686 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001453207.1 KEGG: vfi:VF0935 2.0e-78 Na(+)-translocating NADH-quinone reductase subunit E K03617; COG: COG4657 Predicted NADH:ubiquinone oxidoreductase, subunit RnfA; Psort location: plasma membrane, score: 23 YP_001453208.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_001453209.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_001453210.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents YP_001453211.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen YP_001453212.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase YP_001453213.1 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines YP_001453214.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation YP_001453215.1 KEGG: stm:STM1451 5.8e-88 gst; glutaTHIonine S-transferase K00799; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001453216.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_001453217.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_001453218.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate YP_001453219.1 MliC; membrane-bound lysozyme inhibitor of c-type lysozyme YP_001453220.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_001453221.1 COG: COG3133 Outer membrane lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001453222.1 Transcription regulator that can both activate or repress expression YP_001453223.1 COG: NOG13888 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453224.1 KEGG: ece:Z0125 0.0037 aceF; pyruvate dehydrogenase (dihydrolipoyltransacetylase component) K00627; COG: COG1566 Multidrug resistance efflux pump; Psort location: golgi, score: 9 YP_001453225.1 COG: COG1289 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001453226.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water YP_001453227.1 KEGG: ecc:c2039 2.7e-147 ydhF; hypothetical oxidoreductase YdhF; COG: COG4989 Predicted oxidoreductase; Psort location: cytoskeletal, score: 9 YP_001453228.1 COG: COG3313 Predicted Fe-S protein; Psort location: nuclear, score: 23 YP_001453229.1 KEGG: bpm:BURPS1710b_A2293 1.5e-34 TetR-family regulatory protein K00356; COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001453230.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide YP_001453231.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione YP_001453232.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_001453233.1 KEGG: ama:AM1083 5.9e-08 grxC1; glutaredoxin 3 K03676; COG: COG0278 Glutaredoxin-related protein; Psort location: cytoplasmic, score: 23 YP_001453234.1 Psort location: nuclear, score: 23 YP_001453235.1 KEGG: ssn:SSO_1501 3.4e-99 ydhO; putative lipoprotein K01183; COG: COG0791 Cell wall-associated hydrolases (invasion-associated proteins); Psort location: nuclear, score: 23 YP_001453236.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals YP_001453237.1 KEGG: eci:UTI89_C5041 0.0032 yjiJ; hypothetical protein YjiJ K00403; COG: COG2814 Arabinose efflux permease; Psort location: plasma membrane, score: 23 YP_001453238.1 Psort location: cytoplasmic, score: 23 YP_001453239.1 Psort location: cytoplasmic, score: 23 YP_001453240.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers YP_001453241.1 KEGG: shn:Shewana3_3435 0.00012 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001453242.1 Psort location: nuclear, score: 23 YP_001453243.1 uncharacterized member of the major facilitator superfamily (MFS) YP_001453244.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge YP_001453245.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_001453246.1 Psort location: cytoplasmic, score: 23 YP_001453247.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones YP_001453248.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space YP_001453249.1 KEGG: btk:BT9727_3479 3.7e-22 possible esterase; COG: COG2819 Predicted hydrolase of the alpha/beta superfamily; Psort location: cytoplasmic, score: 23 YP_001453250.1 KEGG: eci:UTI89_C0791 1.2e-08 ybhP; putative DNase; COG: COG3568 Metal-dependent hydrolase; Psort location: extracellular, including cell wall, score: 9 YP_001453251.1 Psort location: mitochondrial, score: 23 YP_001453252.1 Psort location: cytoplasmic, score: 23 YP_001453253.1 Psort location: mitochondrial, score: 23 YP_001453254.1 Psort location: cytoplasmic, score: 23 YP_001453255.1 Psort location: nuclear, score: 23 YP_001453256.1 KEGG: bur:Bcep18194_A4762 8.6e-71 ABC amino acid transporter, periplasmic ligand binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001453257.1 KEGG: nma:NMA0900 1.1e-72 putative polar amino acid transport system ATP-binding protein K02028; COG: COG1126 ABC-type polar amino acid transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001453258.1 KEGG: sma:SAV6546 1.1e-15 putative ABC transporter permease K02028; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001453259.1 KEGG: hpa:HPAG1_0922 7.6e-15 amino acid ABC transporter, permease protein; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001453260.1 Psort location: cytoplasmic, score: 23 YP_001453261.1 KEGG: mag:amb2674 1.7e-08 cytochrome b subunit of formate dehydrogenase K00127; COG: COG4117 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein); Psort location: endoplasmic reticulum, score: 9 YP_001453262.1 KEGG: eci:UTI89_C1863 3.7e-118 putative oxidoreductase Fe-S subunit K00178; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: nuclear, score: 23 YP_001453263.1 COG: NOG06203 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453264.1 KEGG: eci:UTI89_C1865 0. ydhV; hypothetical protein YdhV K03738; COG: COG2414 Aldehyde:ferredoxin oxidoreductase; Psort location: cytoplasmic, score: 23 YP_001453265.1 KEGG: eci:UTI89_C1866 1.1e-107 ydhY; putative ferredoxin-like protein YdhY K00199; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: cytoplasmic, score: 23 YP_001453266.1 COG: NOG13889 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453267.1 Psort location: mitochondrial, score: 23 YP_001453268.1 COG: COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen; Psort location: extracellular, including cell wall, score: 9 YP_001453269.1 KEGG: baa:BA_0884 4.3e-37 binding-protein-dependent transport systems inner membrane component K00294; COG: COG2011 ABC-type metal ion transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001453270.1 KEGG: rru:Rru_A0788 6.2e-84 ABC transporter component K06020; COG: COG1135 ABC-type metal ion transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001453271.1 Psort location: mitochondrial, score: 23 YP_001453272.1 KEGG: plu:plu0524 1.4e-164 unnamed protein product; similar to cystaTHIonine beta-synthase K01697; COG: COG0031 Cysteine synthase; Psort location: cytoplasmic, score: 23 YP_001453273.1 KEGG: plu:plu0523 1.2e-149 unnamed protein product; similar to cystaTHIonine gamma-lyase K01758; COG: COG0626 CystaTHIonine beta-lyases/cystaTHIonine gamma-synthases; Psort location: cytoplasmic, score: 23 YP_001453274.1 Psort location: cytoplasmic, score: 23 YP_001453275.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001453276.1 COG: COG4238 Murein lipoprotein; Psort location: nuclear, score: 23 YP_001453277.1 KEGG: eci:UTI89_C2228 5.3e-62 erfK; hypothetical protein K00257; COG: COG1376 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001453278.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine YP_001453279.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine YP_001453280.1 with SufBC activates cysteine desulfurase SufS YP_001453281.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE YP_001453282.1 with SufCD activates cysteine desulfurase SufS YP_001453283.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein YP_001453284.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001453285.1 KEGG: pen:PSEEN4353 5.9e-63 metallo-beta-lactamase superfamily protein K01475; COG: COG0491 Zn-dependent hydrolases, including glyoxylases; Psort location: extracellular, including cell wall, score: 9 YP_001453286.1 COG: NOG11331 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453287.1 KEGG: eco:b1686 2.8e-65 ydiI; hypothetical protein; COG: COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; Psort location: cytoplasmic, score: 23 YP_001453288.1 KEGG: eci:UTI89_C1879 0. ydiJ; hypothetical protein YdiJ; COG: COG0247 Fe-S oxidoreductase; Psort location: cytoplasmic, score: 23 YP_001453289.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function YP_001453290.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001453291.1 Psort location: mitochondrial, score: 23 YP_001453292.1 COG: COG1806 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001453293.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate YP_001453294.1 Psort location: cytoplasmic, score: 23 YP_001453295.1 COG: COG4256 Hemin uptake protein; Psort location: nuclear, score: 23 YP_001453296.1 COG: COG0397 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001453297.1 COG: COG2200 FOG: EAL domain; Psort location: cytoplasmic, score: 23 YP_001453298.1 Psort location: cytoplasmic, score: 23 YP_001453299.1 KEGG: eci:UTI89_C1901 1.5e-71 nlpC; probable lipoprotein NlpC precursor; COG: COG0791 Cell wall-associated hydrolases (invasion-associated proteins); Psort location: extracellular, including cell wall, score: 9 YP_001453300.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell YP_001453301.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane YP_001453302.1 KEGG: sty:HCM1.216 4.8e-61 bla; beta-lactamase K01467; COG: COG2367 Beta-lactamase class A; Psort location: cytoplasmic, score: 23 YP_001453303.1 with BtuD and BtuF transports vitamin B12 into the cell YP_001453304.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001453305.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001453306.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001453307.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001453308.1 Psort location: cytoplasmic, score: 23 YP_001453309.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_001453310.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001453311.1 Psort location: nuclear, score: 23 YP_001453312.1 COG: COG3137 Putative salt-induced outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001453313.1 KEGG: stm:STM1326 2.9e-148 pfkB; 6-phosphofructokinase II K00850; COG: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); Psort location: extracellular, including cell wall, score: 9 YP_001453314.1 COG: NOG12163 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453315.1 KEGG: eci:UTI89_C1919 2.2e-152 yniA; hypothetical protein YniA K00924; COG: COG3001 Fructosamine-3-kinase; Psort location: cytoplasmic, score: 23 YP_001453316.1 COG: NOG07880 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 23 YP_001453317.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate YP_001453318.1 KEGG: spt:SPA2884 7.4e-104 kduD; 2-keto-3-deoxygluconate oxidoreductase K00065; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001453319.1 COG: COG1988 Predicted membrane-bound metal-dependent hydrolases; Psort location: endoplasmic reticulum, score: 9 YP_001453320.1 KEGG: eci:UTI89_C4668 2.4e-36 gltP; glutamate-aspartate symport protein K03309; COG: COG1823 Predicted Na+/dicarboxylate symporter; Psort location: plasma membrane, score: 23 YP_001453321.1 COG: NOG11329 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001453322.1 Psort location: mitochondrial, score: 23 YP_001453323.1 KEGG: eci:UTI89_C1926 5.3e-110 ydjC; hypothetical protein YdjC K03478; COG: COG3394 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001453324.1 KEGG: sec:SC1337 2.7e-232 celF; phospho-beta-glucosidase (cellobiose-6-phosphate hydrolase) K01222; COG: COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001453325.1 represses the celABCDF-ydjC operon involved in carbon uptake YP_001453326.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_001453327.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_001453328.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_001453329.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein YP_001453330.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_001453331.1 Psort location: mitochondrial, score: 23 YP_001453332.1 COG: COG3758 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001453333.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP YP_001453334.1 Psort location: mitochondrial, score: 23 YP_001453335.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism YP_001453336.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation YP_001453337.1 KEGG: eco:b1746 8.1e-233 astD, ydjU; succinylglutamic semialdehyde dehydrogenase K06447; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001453338.1 KEGG: ecj:JW1736 2.0e-174 astA; arginine succinyltransferase K00673; COG: COG3138 Arginine/orniTHIne N-succinyltransferase beta subunit; Psort location: cytoplasmic, score: 23 YP_001453339.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate YP_001453340.1 Psort location: nuclear, score: 23 YP_001453341.1 Psort location: nuclear, score: 23 YP_001453342.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction YP_001453343.1 KEGG: rfr:Rfer_1621 3.8e-52 pyridine nucleotide-disulphide oxidoreductase dimerisation protein K00520; COG: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes; Psort location: endoplasmic reticulum, score: 9 YP_001453344.1 COG: COG4134 ABC-type uncharacterized transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001453345.1 KEGG: cyb:CYB_0398 0.00020 modB; molybdate ABC transporter, permease protein K02018; COG: COG4135 ABC-type uncharacterized transport system, permease component; Psort location: plasma membrane, score: 23 YP_001453346.1 KEGG: bcl:ABC1229 1.6e-30 sulfate ABC transporter ATP-binding protein K02045; COG: COG4136 ABC-type uncharacterized transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001453347.1 Psort location: cytoplasmic, score: 23 YP_001453348.1 KEGG: ecc:c2158 2.4e-208 putative THIosulfate sulfurtransferase YnjE precursor K01010; COG: COG2897 Rhodanese-related sulfurtransferase; Psort location: extracellular, including cell wall, score: 9 YP_001453349.1 KEGG: ecp:ECP_1704 3.5e-97 hypothetical protein YnjF (probable CDP-alcohol phosphatidyltransferase K01005; COG: COG0558 Phosphatidylglycerophosphate synthase; Psort location: endoplasmic reticulum, score: 9 YP_001453350.1 KEGG: aha:AHA_1548 2.2e-31 pcaC; 4-carboxymuconolactone decarboxylase domain protein K01607; COG: COG2128 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001453351.1 Psort location: nuclear, score: 23 YP_001453352.1 KEGG: sec:SC1323 1.4e-54 nudG; putative mutator MutT protein K08320; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001453353.1 COG: NOG11328 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001453354.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_001453355.1 decatenates replicating daughter chromosomes YP_001453356.1 catalyzes the formation of selenophosphate from selenide and ATP YP_001453357.1 KEGG: sbo:SBO_1322 1.5e-87 ydjA; hypothetical protein; COG: COG0778 Nitroreductase; Psort location: cytoplasmic, score: 23 YP_001453358.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane YP_001453359.1 Psort location: nuclear, score: 23 YP_001453360.1 Psort location: nuclear, score: 23 YP_001453361.1 converts asparagine to aspartate and ammonia YP_001453362.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide YP_001453363.1 COG: COG3139 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001453364.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_001453365.1 KEGG: stt:t1169 8.8e-172 gapA; glyceraldehyde 3-phosphate dehydrogenase A K00134; COG: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001453366.1 KEGG: tbd:Tbd_2730 3.0e-36 dihydroxy-acid dehydratase K01687; COG: COG0676 Uncharacterized enzymes related to aldose 1-epimerase; Psort location: cytoplasmic, score: 23 YP_001453367.1 Psort location: nuclear, score: 23 YP_001453368.1 Psort location: mitochondrial, score: 23 YP_001453369.1 COG: COG3713 Outer membrane protein V; Psort location: extracellular, including cell wall, score: 9 YP_001453370.1 Psort location: nuclear, score: 23 YP_001453371.1 KEGG: eci:UTI89_C1979 0. yeaG; hypothetical protein K07180; COG: COG2766 Putative Ser protein kinase; Psort location: cytoplasmic, score: 23 YP_001453372.1 KEGG: eci:UTI89_C1980 9.7e-221 yeaH; hypothetical protein YeaH K00754; COG: COG2718 Uncharacterized conserved protein; Psort location: nuclear, score: 23 YP_001453373.1 KEGG: mbo:Mb2655 1.2e-30 possible methyltransferase (methylase) K00599; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001453374.1 KEGG: eci:UTI89_C1612 3.4e-12 ydaM; hypothetical protein YdaM; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001453375.1 KEGG: lpl:lp_2048 0.00061 proS, pro; prolyl-tRNA synthetase K01881; COG: COG2606 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001453376.1 COG: COG2707 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001453377.1 KEGG: pfo:Pfl_2158 0.0029 methylated-DNA-(protein)-cysteine S-methyltransferase K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001453378.1 COG: COG2807 Cyanate permease; Psort location: plasma membrane, score: 23 YP_001453379.1 KEGG: aba:Acid345_2856 1.2e-57 CTP synthase K01937; COG: COG0504 CTP synthase (UTP-ammonia lyase); Psort location: cytoplasmic, score: 23 YP_001453380.1 Psort location: cytoplasmic, score: 23 YP_001453381.1 KEGG: eci:UTI89_C1988 1.8e-47 yeaO; hypothetical protein K00589; COG: COG3189 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001453382.1 COG: COG3042 Putative hemolysin; Psort location: extracellular, including cell wall, score: 9 YP_001453383.1 KEGG: cya:CYA_1318 0.0051 gspO; prepilin peptidase K02464; COG: COG2261 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001453384.1 Psort location: nuclear, score: 23 YP_001453385.1 KEGG: eca:ECA1250 0. fdhF; formate dehydrogenase H K00123; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001453386.1 COG: NOG24806 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001453387.1 COG: NOG15334 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 23 YP_001453388.1 COG: COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance; Psort location: cytoplasmic, score: 23 YP_001453389.1 COG: COG1280 Putative threonine efflux protein; Psort location: plasma membrane, score: 23 YP_001453390.1 Psort location: cytoplasmic, score: 23 YP_001453391.1 COG: COG3443 Predicted periplasmic or secreted protein; Psort location: cytoplasmic, score: 23 YP_001453392.1 KEGG: eci:UTI89_C2076 0. bisZ; trimethylamine-N-oxide reductase 2 precursor K07812; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001453393.1 KEGG: eci:UTI89_C2480 7.4e-33 napC; cytochrome c protein, subunit of nitrate reductase, periplasmic K02569; COG: COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit; Psort location: nuclear, score: 23 YP_001453394.1 COG: COG0589 Universal stress protein UspA and related nucleotide-binding proteins; Psort location: cytoplasmic, score: 23 YP_001453395.1 Psort location: extracellular, including cell wall, score: 9 YP_001453396.1 KEGG: sgl:SG1047 2.2e-95 lipid A biosynthesis lauroyl acyltransferase K02517; COG: COG1560 Lauroyl/myristoyl acyltransferase; Psort location: mitochondrial, score: 23 YP_001453397.1 Converts isocitrate to alpha ketoglutarate YP_001453398.1 KEGG: sec:SC1188 3.1e-05 ymfC; putative ribosomal large subunit pseudouridine synthase K06181; Psort location: cytoplasmic, score: 23 YP_001453399.1 KEGG: ecp:ECP_1130 3.3e-101 putative ribosomal large subunit pseudouridine synthase K06181; COG: COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Psort location: mitochondrial, score: 23 YP_001453400.1 KEGG: stm:STM1235 1.5e-73 ymfB; putative MutT-like protein; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001453401.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001453402.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis YP_001453403.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_001453404.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization YP_001453405.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization YP_001453406.1 COG: COG2246 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001453407.1 KEGG: stm:STM0558 1.0e-152 yfdH; putative glycosyltransferase K00754; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: endoplasmic reticulum, score: 9 YP_001453408.1 COG: NOG18272 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001453409.1 Psort location: cytoplasmic, score: 23 YP_001453410.1 Psort location: cytoplasmic, score: 23 YP_001453411.1 COG: NOG11915 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001453412.1 Psort location: cytoplasmic, score: 23 YP_001453413.1 COG: NOG14937 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453414.1 COG: NOG22088 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453415.1 KEGG: eci:UTI89_C5128 1.4e-44 putative tail length tape measure protein precursor K00924; COG: COG5281 Phage-related minor tail protein; Psort location: cytoskeletal, score: 9 YP_001453416.1 Psort location: nuclear, score: 23 YP_001453417.1 Psort location: mitochondrial, score: 23 YP_001453418.1 Psort location: cytoplasmic, score: 23 YP_001453419.1 KEGG: chu:CHU_1335 4.1e-09 CHU large protein; endoglucanase-related protein, glucosyl hydrolase family 9 protein K01238; COG: COG5492 Bacterial surface proteins containing Ig-like domains; Psort location: cytoplasmic, score: 23 YP_001453420.1 Psort location: endoplasmic reticulum, score: 9 YP_001453421.1 COG: NOG18338 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001453422.1 Psort location: extracellular, including cell wall, score: 9 YP_001453423.1 Psort location: cytoplasmic, score: 23 YP_001453424.1 Psort location: cytoplasmic, score: 23 YP_001453425.1 Psort location: cytoplasmic, score: 23 YP_001453426.1 KEGG: sco:SCO1554 0.00052 SCL11.10c; putative nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase K04719; COG: KOG3544 Collagens (type IV and type XIII), and related proteins; Psort location: nuclear, score: 23 YP_001453427.1 Psort location: cytoplasmic, score: 23 YP_001453428.1 COG: NOG22367 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453429.1 Psort location: cytoplasmic, score: 23 YP_001453430.1 COG: NOG09073 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453431.1 COG: NOG14014 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453432.1 COG: NOG31953 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453433.1 COG: COG5556 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001453434.1 COG: NOG11517 non supervised orthologous group; Psort location: cytoskeletal, score: 9 YP_001453435.1 Psort location: mitochondrial, score: 23 YP_001453436.1 Psort location: nuclear, score: 23 YP_001453437.1 Psort location: cytoskeletal, score: 9 YP_001453438.1 COG: NOG11447 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001453439.1 KEGG: ecc:c1436 2.4e-75 probable lysozyme from lambdoid prophage Qin K01185; COG: COG3772 Phage-related lysozyme (muraminidase); Psort location: extracellular, including cell wall, score: 9 YP_001453440.1 Psort location: extracellular, including cell wall, score: 9 YP_001453441.1 Psort location: cytoplasmic, score: 23 YP_001453442.1 Psort location: cytoplasmic, score: 23 YP_001453443.1 COG: NOG28546 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453444.1 COG: NOG24469 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453445.1 COG: NOG09761 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001453446.1 COG: COG4570 Holliday junction resolvase; Psort location: nuclear, score: 23 YP_001453447.1 Psort location: mitochondrial, score: 23 YP_001453448.1 Psort location: cytoplasmic, score: 23 YP_001453449.1 Psort location: nuclear, score: 23 YP_001453450.1 COG: NOG06198 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453451.1 COG: NOG29483 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453452.1 Psort location: cytoplasmic, score: 23 YP_001453453.1 COG: NOG18526 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453454.1 Psort location: cytoplasmic, score: 23 YP_001453455.1 Psort location: nuclear, score: 23 YP_001453456.1 Psort location: endoplasmic reticulum, score: 9 YP_001453457.1 Psort location: endoplasmic reticulum, score: 9 YP_001453458.1 KEGG: tpv:TP02_0197 0.00020 hexaprenyldihydroxybenzoate methyltransferase K00591; COG: NOG13524 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453459.1 KEGG: wsu:WS1010 5.1e-06 cysH; APS reductase K00390; COG: COG0175 3-phosphoadenosine 5-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001453460.1 Psort location: cytoplasmic, score: 23 YP_001453461.1 Psort location: cytoplasmic, score: 23 YP_001453462.1 COG: NOG29340 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453463.1 COG: NOG25367 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453464.1 COG: NOG20728 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001453465.1 COG: NOG18590 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001453466.1 KEGG: bms:BR0354 0.0047 chlorohydrolase family protein K01487; Psort location: cytoplasmic, score: 23 YP_001453467.1 COG: NOG12180 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453468.1 COG: NOG36342 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001453469.1 COG: NOG16728 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001453470.1 Psort location: nuclear, score: 23 YP_001453471.1 Psort location: cytoplasmic, score: 23 YP_001453472.1 Psort location: cytoplasmic, score: 23 YP_001453473.1 Psort location: nuclear, score: 23 YP_001453474.1 Psort location: cytoplasmic, score: 23 YP_001453475.1 Psort location: cytoplasmic, score: 23 YP_001453476.1 Psort location: extracellular, including cell wall, score: 9 YP_001453477.1 COG: NOG36471 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001453478.1 Psort location: cytoplasmic, score: 23 YP_001453479.1 KEGG: sty:STY2073 9.8e-173 recE; exodeoxyribonuclease VIII K01146; COG: NOG06785 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453480.1 COG: NOG11393 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453481.1 COG: NOG30287 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453482.1 Psort location: mitochondrial, score: 23 YP_001453483.1 COG: NOG38598 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453484.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001453485.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress YP_001453486.1 KEGG: spt:SPA1620 7.4e-239 phoQ; sensor protein PhoQ, regulator of virulence determinants K07637; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 23 YP_001453487.1 Psort location: cytoplasmic, score: 23 YP_001453488.1 COG: COG2850 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001453489.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_001453490.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase YP_001453491.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component YP_001453492.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component YP_001453493.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate YP_001453494.1 KEGG: ssn:SSO_1140 2.5e-119 cobB; putative nicotinic acid mononucleotide:5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase K01463; COG: COG0846 NAD-dependent protein deacetylases, SIR2 family; Psort location: extracellular, including cell wall, score: 9 YP_001453495.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine YP_001453496.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_001453497.1 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone YP_001453498.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_001453499.1 KEGG: eci:UTI89_C1243 2.7e-161 ycfT; hypothetical protein K00680; COG: COG4763 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001453500.1 KEGG: eci:UTI89_C1242 0. mfd; transcription-repair coupling factor; mutation frequency decline K03723; COG: COG1197 Transcription-repair coupling factor (superfamily II helicase); Psort location: cytoplasmic, score: 23 YP_001453501.1 Psort location: cytoplasmic, score: 23 YP_001453502.1 Psort location: nuclear, score: 23 YP_001453503.1 Psort location: nuclear, score: 23 YP_001453504.1 KEGG: eci:UTI89_C2228 4.7e-70 erfK; hypothetical protein K00257; COG: COG1376 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001453505.1 KEGG: reu:Reut_B4338 0.0030 copper/zinc superoxide dismutase K04565; COG: NOG13874 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001453506.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001453507.1 COG: COG3134 Predicted outer membrane lipoprotein; Psort location: endoplasmic reticulum, score: 9 YP_001453508.1 Psort location: mitochondrial, score: 23 YP_001453509.1 KEGG: eci:UTI89_C1237 3.3e-220 ndh; NADH dehydrogenase K03885; COG: COG1252 NADH dehydrogenase, FAD-containing subunit; Psort location: cytoskeletal, score: 9 YP_001453510.1 Psort location: cytoplasmic, score: 23 YP_001453511.1 COG: COG3150 Predicted esterase; Psort location: cytoplasmic, score: 23 YP_001453512.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides YP_001453513.1 catalyzes the phosphorylation of thiamine to thiamine phosphate YP_001453514.1 COG: COG3417 Collagen-binding surface adhesin SpaP (antigen I/II family); Psort location: extracellular, including cell wall, score: 9 YP_001453515.1 COG: COG5633 Predicted periplasmic lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001453516.1 KEGG: eci:UTI89_C1231 4.1e-55 ycfF; HIT-like protein YcfF K01518; COG: COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases; Psort location: cytoplasmic, score: 23 YP_001453517.1 COG: COG4773 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid; Psort location: extracellular, including cell wall, score: 9 YP_001453518.1 Psort location: nuclear, score: 23 YP_001453519.1 Psort location: mitochondrial, score: 23 YP_001453520.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001453521.1 KEGG: eco:b1100 6.8e-133 ycfH; hypothetical protein K03424; COG: COG0084 Mg-dependent DNase; Psort location: cytoplasmic, score: 23 YP_001453522.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_001453523.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_001453524.1 KEGG: eci:UTI89_C1224 8.0e-162 yceG; putative thymidylate kinase; COG: COG1559 Predicted periplasmic solute-binding protein; Psort location: extracellular, including cell wall, score: 9 YP_001453525.1 KEGG: sec:SC1148 3.0e-107 pabC; 4-amino-4-deoxychorismate lyase K02619; COG: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; Psort location: cytoplasmic, score: 23 YP_001453526.2 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001453527.1 carries the fatty acid chain in fatty acid biosynthesis YP_001453528.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001453529.1 KEGG: ecp:ECP_1084 5.6e-154 malonyl CoA-acyl carrier protein transacylase K00645; COG: COG0331 (acyl-carrier-protein) S-malonyltransferase; Psort location: cytoplasmic, score: 23 YP_001453530.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_001453531.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_001453532.1 COG: COG1399 Predicted metal-binding, possibly nucleic acid-binding protein; Psort location: cytoplasmic, score: 23 YP_001453533.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_001453534.1 Psort location: cytoplasmic, score: 23 YP_001453535.1 Psort location: nuclear, score: 23 YP_001453536.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA YP_001453537.1 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase YP_001453538.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes YP_001453539.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_001453540.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space YP_001453541.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_001453542.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod YP_001453543.1 makes up the distal portion of the flagellar basal body rod YP_001453544.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod YP_001453545.1 the hook connects flagellar basal body to the flagellar filament YP_001453546.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production YP_001453547.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_001453548.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella YP_001453549.1 required for the assembly of the flagellar basal body P-ring YP_001453550.1 regulates the flagellar specific sigma28 transcription factor YP_001453551.1 COG: COG3418 Flagellar biosynthesis/type III secretory pathway chaperone; Psort location: nuclear, score: 23 YP_001453552.1 Psort location: nuclear, score: 23 YP_001453553.1 COG: COG0728 Uncharacterized membrane protein, putative virulence factor; Psort location: plasma membrane, score: 23 YP_001453554.1 Psort location: cytoplasmic, score: 23 YP_001453555.1 Psort location: cytoplasmic, score: 23 YP_001453556.1 KEGG: lpl:lp_0813 5.8e-33 oxidoreductase (putative) K03810; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001453557.1 COG: COG3132 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001453558.1 KEGG: sec:SC1115 3.5e-65 rimJ; acetylation of N-terminal alanine of 30S ribosomal subunit protein S5 K03790; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001453559.1 KEGG: sec:SC2531 0.0026 pepB; putative aminopeptidase K07751; Psort location: nuclear, score: 23 YP_001453560.1 Confers resistance to norfloxacin and enoxacin YP_001453561.1 cofactor involved in the reduction of disulfides YP_001453562.1 COG: NOG07875 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001453563.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_001453564.1 COG: NOG13873 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453565.1 Psort location: cytoplasmic, score: 23 YP_001453566.1 Psort location: cytoplasmic, score: 23 YP_001453567.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing YP_001453568.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids YP_001453569.1 COG: NOG18117 non supervised orthologous group; Psort location: golgi, score: 9 YP_001453570.1 Psort location: nuclear, score: 23 YP_001453571.1 KEGG: reh:H16_A3123 1.5e-25 cytochrome b561 K00156; COG: COG3038 Cytochrome B561; Psort location: endoplasmic reticulum, score: 9 YP_001453572.1 COG: COG2353 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001453573.1 KEGG: pub:SAR11_1074 3.7e-22 yceA; rhodanese domain protein; COG: COG1054 Predicted sulfurtransferase; Psort location: cytoplasmic, score: 23 YP_001453574.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_001453575.1 Psort location: cytoplasmic, score: 23 YP_001453576.1 Psort location: nuclear, score: 23 YP_001453577.1 Confers resistance to fosfomycin and deoxycholate YP_001453578.1 COG: NOG09842 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453579.1 COG: COG5645 Predicted periplasmic lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001453580.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space YP_001453581.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan YP_001453582.1 required for the transfer of succinyl residues to the glucan backbone YP_001453583.1 KEGG: reh:H16_B1107 3.5e-113 phospholipase D K01115; COG: COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes; Psort location: cytoplasmic, score: 23 YP_001453584.1 KEGG: reh:H16_A1552 3.3e-46 predicted phosphatase homolog to the C-terminal domain of histone macroH2A1; COG: COG2110 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1; Psort location: cytoplasmic, score: 23 YP_001453585.1 COG: NOG18522 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001453586.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers YP_001453587.1 COG: NOG09021 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001453588.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface YP_001453589.1 Psort location: cytoplasmic, score: 23 YP_001453590.1 Psort location: cytoplasmic, score: 23 YP_001453591.1 activates the csgBA and csgDEFG operons involved in biofilm formation YP_001453592.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex YP_001453593.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex YP_001453594.1 COG: COG1462 Uncharacterized protein involved in formation of curli polymers; Psort location: mitochondrial, score: 23 YP_001453595.1 COG: NOG09737 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001453596.1 KEGG: vfi:VFA0083 2.8e-08 ynfI; anaerobic dimethyl sulfoxide reductase chain YnfI K00397; COG: COG3381 Uncharacterized component of anaerobic dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001453597.1 KEGG: eci:UTI89_C1155 2.6e-117 ycdX; hypothetical protein K04477; COG: COG1387 Histidinol phosphatase and related hydrolases of the PHP family; Psort location: cytoplasmic, score: 23 YP_001453598.1 KEGG: eco:b1033 1.3e-136 ycdW; 2-ketoacid reductase K00049; COG: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001453599.1 Psort location: endoplasmic reticulum, score: 9 YP_001453600.1 Psort location: cytoplasmic, score: 23 YP_001453601.1 KEGG: reh:H16_A0527 5.1e-41 phoH; phosphate starvation-inducible protein PhoH,predicted ATPase; COG: COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001453602.1 KEGG: rpr:RP465 1.3e-07 phoR; alkaline phosphatase synthesis sensor protein phoR K07636; COG: COG0591 Na+/proline symporter; Psort location: plasma membrane, score: 23 YP_001453603.1 Psort location: nuclear, score: 23 YP_001453604.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein YP_001453605.1 COG: COG3755 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001453606.1 KEGG: bcl:ABC2937 0.0053 NADH dehydrogenase K03885; COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001453607.1 COG: COG3729 General stress protein; Psort location: nuclear, score: 23 YP_001453608.1 stationary phase protein that binds TrpR repressor YP_001453609.1 COG: NOG13872 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453610.1 KEGG: ecp:ECP_1001 2.2e-200 glucose-1-phosphatase precursor K01085; COG: NOG06770 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001453611.1 Psort location: cytoplasmic, score: 23 YP_001453612.1 KEGG: reh:H16_A0306 5.1e-09 bcp; peroxiredoxin K00435; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: extracellular, including cell wall, score: 9 YP_001453613.1 KEGG: rru:Rru_A2804 1.8e-68 ABC transporter component K06020; COG: COG1136 ABC-type antimicrobial peptide transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001453614.1 KEGG: pen:PSEEN3665 3.9e-12 efflux ABC transporter, ATP-binding/permease protein; COG: COG0577 ABC-type antimicrobial peptide transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001453615.1 KEGG: cch:Cag_0337 3.2e-16 ATPase K06020; COG: COG0577 ABC-type antimicrobial peptide transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001453616.1 COG: COG4393 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001453617.1 COG: COG3470 Uncharacterized protein probably involved in high-affinity Fe2+ transport; Psort location: endoplasmic reticulum, score: 9 YP_001453618.1 COG: COG0672 High-affinity Fe2+/Pb2+ permease; Psort location: plasma membrane, score: 23 YP_001453619.1 Psort location: nuclear, score: 23 YP_001453620.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_001453621.1 KEGG: ngo:NGO2059 2.1e-09 putative peptide meTHIonine sulfoxide reductase K07304:K07305; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: extracellular, including cell wall, score: 9 YP_001453622.1 KEGG: eba:ebA6610 7.2e-05 dsbC; periplasmic THIol:disulfide interchange protein K03981; COG: COG1651 Protein-disulfide isomerase; Psort location: extracellular, including cell wall, score: 9 YP_001453623.1 KEGG: xcc:XCC0519 6.7e-56 dsbD; c-type cytochrome biogenesis protein K04084; COG: COG4233 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis; Psort location: endoplasmic reticulum, score: 9 YP_001453624.1 Psort location: cytoplasmic, score: 23 YP_001453625.1 COG: NOG29928 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001453626.1 Psort location: mitochondrial, score: 23 YP_001453627.1 functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock YP_001453628.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA YP_001453629.1 Psort location: cytoplasmic, score: 23 YP_001453630.1 COG: COG3093 Plasmid maintenance system antidote protein; Psort location: cytoplasmic, score: 23 YP_001453631.1 COG: COG3549 Plasmid maintenance system killer protein; Psort location: nuclear, score: 23 YP_001453632.1 Psort location: mitochondrial, score: 23 YP_001453633.1 KEGG: eci:UTI89_C1055 6.3e-146 yccM; putative electron transport protein YccM K00168; COG: COG0348 Polyferredoxin; Psort location: endoplasmic reticulum, score: 23 YP_001453634.1 KEGG: eca:ECA1530 5.7e-97 tauB, ssiB; putative taurine transport ATP-binding protein K02049; COG: COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001453635.1 KEGG: rha:RHA1_ro08170 8.5e-16 ABC transporter, permease component; COG: COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001453636.1 COG: COG4521 ABC-type taurine transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 23 YP_001453637.1 KEGG: eca:ECA1532 4.9e-75 putative aspartate racemase K01779; COG: COG1794 Aspartate racemase; Psort location: cytoplasmic, score: 23 YP_001453638.1 catalyzes the formation of pyruvate from D-cysteine YP_001453639.1 Psort location: nuclear, score: 23 YP_001453640.1 Psort location: cytoplasmic, score: 23 YP_001453641.1 KEGG: eca:ECA1527 6.8e-94 putative malate/lactate dehydrogenase K00025; COG: COG2055 Malate/L-lactate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001453642.1 COG: COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components; Psort location: extracellular, including cell wall, score: 9 YP_001453643.1 KEGG: reh:H16_B2218 6.1e-93 ABC-type transporter, ATPase component: NitT family; COG: COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001453644.1 KEGG: lwe:lwe1444 2.4e-14 opuCB; glycine betaine/L-proline ABC transporter, permease protein; COG: COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001453645.1 COG: NOG22558 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001453646.1 COG: NOG26107 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453647.1 COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: extracellular, including cell wall, score: 9 YP_001453648.1 Psort location: cytoplasmic, score: 23 YP_001453649.1 COG: NOG22124 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453650.1 KEGG: eci:UTI89_C2502 2.0e-30 atoC; acetoacetate metabolism regulatory protein AtoC K07714; COG: COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains; Psort location: cytoplasmic, score: 23 YP_001453651.1 KEGG: sec:SC2398 0. pgtB; phosphoglycerate transport: protein for signal transmission K08475; COG: COG4192 Signal transduction histidine kinase regulating phosphoglycerate transport system; Psort location: endoplasmic reticulum, score: 9 YP_001453652.1 COG: COG1840 ABC-type Fe3+ transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001453653.1 Psort location: cytoplasmic, score: 23 YP_001453654.1 COG: COG2271 Sugar phosphate permease; Psort location: plasma membrane, score: 23 YP_001453655.1 Psort location: nuclear, score: 23 YP_001453656.1 COG: COG0670 Integral membrane protein, interacts with FtsH; Psort location: endoplasmic reticulum, score: 9 YP_001453657.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs YP_001453658.1 catalyzes the hydrolysis of acylphosphate YP_001453659.1 KEGG: eci:UTI89_C1034 2.1e-186 yccW; hypothetical protein YccW K06969; COG: COG1092 Predicted SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001453660.1 COG: COG3785 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001453661.1 KEGG: rru:Rru_A2075 2.1e-30 O-acetylhomoserine/O-acetylserine sulfhydrylase K01740; COG: COG1832 Predicted CoA-binding protein; Psort location: cytoplasmic, score: 23 YP_001453662.1 COG: COG3110 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001453663.1 Psort location: nuclear, score: 23 YP_001453664.1 catalyzes the formation of methylglyoxal from glycerone phosphate YP_001453665.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand YP_001453666.1 KEGG: ecc:c1099 8.2e-05 helD; helicase IV K03658; Psort location: extracellular, including cell wall, score: 9 YP_001453667.1 COG: COG3304 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001453668.1 KEGG: eco:b3358 3.1e-28 yhfK; conserved inner membrane protein K01823; COG: COG1289 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001453669.1 COG: COG3070 Regulator of competence-specific genes; Psort location: cytoplasmic, score: 23 YP_001453670.1 COG: COG5404 SOS-response cell division inhibitor, blocks FtsZ ring formation; Psort location: extracellular, including cell wall, score: 9 YP_001453671.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d YP_001453672.1 KEGG: pfl:PFL_4151 0.0046 peptidase, M24 family protein K01262; COG: COG3120 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001453673.1 KEGG: spt:SPA1782 5.7e-287 lonH; Lon-like ATP-dependent protease K04770; COG: COG1067 Predicted ATP-dependent protease; Psort location: cytoplasmic, score: 23 YP_001453674.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_001453675.1 Psort location: nuclear, score: 23 YP_001453676.1 COG: COG3009 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001453677.1 COG: COG3008 Paraquat-inducible protein B; Psort location: mitochondrial, score: 23 YP_001453678.1 KEGG: sak:SAK_0198 0.0042 glycosyl transferase family protein K02851; COG: COG2995 Uncharacterized paraquat-inducible protein A; Psort location: plasma membrane, score: 23 YP_001453679.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth YP_001453680.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA YP_001453681.1 KEGG: reh:H16_B1359 1.3e-06 paaE2; phenylacetic acid degradation protein E,flavodoxin reductase; COG: COG0633 Ferredoxin; Psort location: cytoplasmic, score: 23 YP_001453682.1 COG: NOG07913 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453683.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_001453684.1 KEGG: eci:UTI89_C1009 2.9e-86 ycbP; FMN reductase K00299; COG: COG0431 Predicted flavoprotein; Psort location: mitochondrial, score: 23 YP_001453685.1 KEGG: mav:MAV_3808 0.00062 2'-hydroxybiphenyl-2-sulfinate desulfinase K05977; COG: COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components; Psort location: extracellular, including cell wall, score: 9 YP_001453686.1 catalyzes the release of sulfite from alkanesulfonates YP_001453687.1 part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease YP_001453688.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease YP_001453689.1 KEGG: stm:STM1057 0. pepN; aminopeptidase N K01256; COG: COG0308 Aminopeptidase N; Psort location: cytoplasmic, score: 23 YP_001453690.1 KEGG: sec:SC1010 1.9e-07 pepN; aminopeptidase N K01256; COG: COG0308 Aminopeptidase N; Psort location: cytoplasmic, score: 23 YP_001453691.1 KEGG: gga:418096 1.1e-17 GNPTAB, LOC418096; N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits K08239; COG: NOG08826 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453692.1 Psort location: cytoplasmic, score: 23 YP_001453693.1 Psort location: cytoplasmic, score: 23 YP_001453694.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_001453695.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001453696.1 Psort location: endoplasmic reticulum, score: 9 YP_001453697.1 Psort location: mitochondrial, score: 23 YP_001453698.1 outer membrane porin F; 1a; Ia; b YP_001453699.1 Psort location: mitochondrial, score: 23 YP_001453700.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_001453701.1 KEGG: eci:UTI89_C0999 1.8e-109 ycbL; hypothetical protein K01069; COG: COG0491 Zn-dependent hydrolases, including glyoxylases; Psort location: extracellular, including cell wall, score: 9 YP_001453702.1 COG: COG3108 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001453703.1 COG: COG2989 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001453704.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects YP_001453705.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division YP_001453706.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division YP_001453707.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA YP_001453708.1 Psort location: mitochondrial, score: 23 YP_001453709.1 COG: COG1434 Uncharacterized conserved protein; Psort location: endoplasmic reticulum, score: 9 YP_001453710.1 COG: NOG06195 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453711.1 Psort location: mitochondrial, score: 23 YP_001453712.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_001453713.1 KEGG: lpn:lpg1920 2.0e-14 lpxK; tetraacyldisaccharide-1-P-4'-kinase K00912; COG: COG2835 Uncharacterized conserved protein; Psort location: nuclear, score: 23 YP_001453714.1 COG: COG3214 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001453715.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_001453716.1 involved in the transport of lipid A across the inner membrane YP_001453717.1 KEGG: xac:XAC1087 0.0012 gloB; hydroxyacylglutaTHIone hydrolase K01069; COG: COG0658 Predicted membrane metal-binding protein; Psort location: plasma membrane, score: 23 YP_001453718.1 Psort location: nuclear, score: 23 YP_001453719.1 Psort location: extracellular, including cell wall, score: 9 YP_001453720.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001453721.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_001453722.1 Psort location: endoplasmic reticulum, score: 9 YP_001453723.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_001453724.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_001453725.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_001453726.1 COG: COG1944 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001453727.1 KEGG: shn:Shewana3_1556 2.6e-76 meTHIonine gamma-lyase K01761; COG: COG2116 Formate/nitrite family of transporters; Psort location: endoplasmic reticulum, score: 23 YP_001453728.1 KEGG: stm:STM0973 0. pflB; pyruvate formate lyase I K00656; COG: COG1882 Pyruvate-formate lyase; Psort location: cytoplasmic, score: 23 YP_001453729.1 activates pyruvate formate-lyase 1 under anaerobic conditions YP_001453730.1 KEGG: eci:UTI89_C5041 7.3e-11 yjiJ; hypothetical protein YjiJ K00403; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 23 YP_001453731.1 Psort location: nuclear, score: 23 YP_001453732.1 Psort location: mitochondrial, score: 23 YP_001453733.1 KEGG: reh:H16_A0619 1.9e-96 YcaC related amidohydrolase K00517; COG: COG1335 Amidases related to nicotinamidase; Psort location: endoplasmic reticulum, score: 9 YP_001453734.1 KEGG: ecp:ECP_0910 2.7e-129 anaerobic dimethyl sulfoxide reductase, subunit C K07308; COG: COG3302 DMSO reductase anchor subunit; Psort location: plasma membrane, score: 23 YP_001453735.1 KEGG: ecp:ECP_0909 2.8e-49 anaerobic dimethyl sulfoxide reductase, subunit B K07307; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: nuclear, score: 23 YP_001453736.1 Psort location: endoplasmic reticulum, score: 9 YP_001453737.1 KEGG: sec:SC0918 0. dmsA; anaerobic dimethyl sulfoxide reductase, subunit A K07306; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001453738.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001453739.1 KEGG: pha:PSHAa1714 8.0e-139 rarA; polynucleotide enzyme with nucleotide triphosphate hydrolase domain K07478; COG: COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase; Psort location: cytoplasmic, score: 23 YP_001453740.1 participates with LolB in the incorporation of lipoprotein into the outer membrane YP_001453741.1 DNA-binding membrane protein required for chromosome resolution and partitioning YP_001453742.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system YP_001453743.1 Psort location: nuclear, score: 23 YP_001453744.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding YP_001453745.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_001453746.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_001453747.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_001453748.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001453749.1 Psort location: nuclear, score: 23 YP_001453750.1 Psort location: nuclear, score: 23 YP_001453751.1 Psort location: cytoplasmic, score: 23 YP_001453752.1 KEGG: shn:Shewana3_3435 3.1e-05 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001453753.1 KEGG: shn:Shewana3_3385 2.5e-32 hypoxanTHIne phosphoribosyltransferase K00760; COG: COG1741 Pirin-related protein; Psort location: cytoplasmic, score: 23 YP_001453754.1 KEGG: psp:PSPPH_0909 9.7e-47 isochorismatase family protein K05993; COG: COG1335 Amidases related to nicotinamidase; Psort location: endoplasmic reticulum, score: 9 YP_001453756.1 COG: NOG09669 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001453757.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates YP_001453758.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_001453759.1 COG: COG1278 Cold shock proteins; Psort location: cytoplasmic, score: 23 YP_001453760.1 with MacA is involved in the export of macrolide YP_001453761.1 confers macrolide resistance via active drug efflux YP_001453762.1 COG: COG3593 Predicted ATP-dependent endonuclease of the OLD family; Psort location: cytoplasmic, score: 23 YP_001453763.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure YP_001453764.1 COG: COG2431 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001453765.1 catalyzes the reduction of hydroxylamine to ammonia and water YP_001453766.1 KEGG: stm:STM0936 4.4e-154 hcr; NADH oxidoreductase for hcp gene product; COG: COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1; Psort location: cytoplasmic, score: 23 YP_001453767.1 COG: COG2259 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001453768.1 Psort location: mitochondrial, score: 23 YP_001453769.1 catalyzes the formation of acetate from pyruvate YP_001453770.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine YP_001453771.1 KEGG: eci:UTI89_C0872 6.7e-229 ybjT; hypothetical protein YbjT K00329:K00356; COG: COG0702 Predicted nucleoside-diphosphate-sugar epimerases; Psort location: mitochondrial, score: 23 YP_001453772.1 Psort location: nuclear, score: 23 YP_001453773.1 KEGG: eci:UTI89_C0871 8.5e-174 ybjS; hypothetical protein YbjS K00067; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001453774.1 KEGG: bam:Bamb_1428 5.9e-37 chitinase K01183; COG: COG3979 Uncharacterized protein contain chitin-binding domain type 3; Psort location: endoplasmic reticulum, score: 9 YP_001453775.1 KEGG: cpe:CPE1992 2.8e-08 probable soluble lytic transglycosylase K01238; COG: COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); Psort location: extracellular, including cell wall, score: 9 YP_001453776.1 KEGG: sdn:Sden_2136 6.8e-284 chitinase K01183; COG: COG3325 Chitinase; Psort location: extracellular, including cell wall, score: 9 YP_001453777.1 KEGG: aha:AHA_3871 3.2e-56 gspO; prepilin peptidase; COG: COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases; Psort location: endoplasmic reticulum, score: 9 YP_001453778.1 COG: COG3149 Type II secretory pathway, component PulM; Psort location: nuclear, score: 23 YP_001453779.1 COG: COG3297 Type II secretory pathway, component PulL; Psort location: cytoplasmic, score: 23 YP_001453780.1 COG: COG3156 Type II secretory pathway, component PulK; Psort location: mitochondrial, score: 23 YP_001453781.1 COG: COG4795 Type II secretory pathway, component PulJ; Psort location: endoplasmic reticulum, score: 9 YP_001453782.1 COG: COG2165 Type II secretory pathway, pseudopilin PulG; Psort location: cytoplasmic, score: 23 YP_001453783.1 COG: COG2165 Type II secretory pathway, pseudopilin PulG; Psort location: extracellular, including cell wall, score: 9 YP_001453784.1 COG: COG2165 Type II secretory pathway, pseudopilin PulG; Psort location: endoplasmic reticulum, score: 9 YP_001453785.1 COG: COG1459 Type II secretory pathway, component PulF; Psort location: endoplasmic reticulum, score: 9 YP_001453786.1 KEGG: pen:PSEEN2333 1.1e-116 xcpR-2; type II secretion pathway protein E K01509; COG: COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB; Psort location: cytoplasmic, score: 23 YP_001453787.1 COG: COG1450 Type II secretory pathway, component PulD; Psort location: extracellular, including cell wall, score: 9 YP_001453788.1 KEGG: rme:Rmet_2422 0.0046 peptidase S1C, Do K04771; COG: COG3031 Type II secretory pathway, component PulC; Psort location: mitochondrial, score: 23 YP_001453789.1 Psort location: cytoplasmic, score: 23 YP_001453790.1 Psort location: nuclear, score: 23 YP_001453791.1 Psort location: nuclear, score: 23 YP_001453792.1 Psort location: nuclear, score: 23 YP_001453793.1 KEGG: rha:RHA1_ro04199 0.0092 DNA polymerase III subunit K00961; Psort location: nuclear, score: 23 YP_001453794.1 COG: NOG25589 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453795.1 KEGG: ecs:ECs0953 1.5e-128 N-acetylmuramoyl-L-alanine amidase K01446; COG: COG3023 Negative regulator of beta-lactamase expression; Psort location: extracellular, including cell wall, score: 9 YP_001453796.1 COG: COG0393 Uncharacterized conserved protein; Psort location: cytoskeletal, score: 9 YP_001453797.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS YP_001453798.1 With ArtMQJI transports arginine across the inner membrane YP_001453799.1 KEGG: eci:UTI89_C2121 3.9e-27 fliY; cystine-binding periplasmic protein precursor K02030:K02424; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001453800.1 with ArtPMJI transports arginine across the inner membrane YP_001453801.1 with ArtPQJI acts to transport arginine across the inner membrane YP_001453802.1 Psort location: cytoplasmic, score: 23 YP_001453803.1 KEGG: eci:UTI89_C2121 1.9e-27 fliY; cystine-binding periplasmic protein precursor K02030:K02424; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001453804.1 KEGG: eci:UTI89_C4932 5.8e-175 hypothetical protein; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001453805.1 KEGG: fal:FRAAL1628 1.3e-49 response regulator in two-component regulatory system; COG: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001453806.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA YP_001453807.1 COG: NOG08677 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001453808.1 Psort location: cytoplasmic, score: 23 YP_001453809.1 KEGG: cyb:CYB_0398 1.7e-13 modB; molybdate ABC transporter, permease protein K02018; COG: COG1177 ABC-type spermidine/putrescine transport system, permease component II; Psort location: plasma membrane, score: 23 YP_001453810.1 KEGG: hpa:HPAG1_0451 2.1e-09 molybdenum ABC transporter ModB K06022; COG: COG1176 ABC-type spermidine/putrescine transport system, permease component I; Psort location: endoplasmic reticulum, score: 9 YP_001453811.1 part of the PotFGHI ATP-dependent putrescine transporter YP_001453812.1 COG: COG0687 Spermidine/putrescine-binding periplasmic protein; Psort location: extracellular, including cell wall, score: 9 YP_001453813.1 COG: NOG08676 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453814.1 KEGG: ava:Ava_1836 6.4e-16 glutaTHIone synthetase K01920; COG: COG0189 GlutaTHIone synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); Psort location: mitochondrial, score: 23 YP_001453815.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds YP_001453816.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function YP_001453817.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase YP_001453818.1 COG: NOG09759 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001453819.1 COG: COG2985 Predicted permease; Psort location: plasma membrane, score: 23 YP_001453820.1 COG: COG3226 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001453821.1 Psort location: mitochondrial, score: 23 YP_001453822.1 Psort location: nuclear, score: 23 YP_001453823.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001453824.1 KEGG: ecp:ECP_0835 6.7e-71 putative hydrolase of the HAD superfamily K07757; COG: COG0561 Predicted hydrolases of the HAD superfamily; Psort location: cytoplasmic, score: 23 YP_001453825.1 KEGG: shn:Shewana3_1692 5.4e-07 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001453826.1 KEGG: btk:BT9727_2194 8.1e-11 probable phosphatase, PAP2 superfamily; possible bacitracin transport permease K01112; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001453827.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001453828.1 penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_001453829.1 KEGG: eci:UTI89_C0841 3.4e-92 yliJ; hypothetical GST-like protein YliJ K00799; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001453830.1 KEGG: azo:azo1253 3.6e-79 conserved hypothetical protein K00117; COG: COG2133 Glucose/sorbosone dehydrogenases; Psort location: extracellular, including cell wall, score: 9 YP_001453831.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing YP_001453832.1 Psort location: cytoplasmic, score: 23 YP_001453833.1 Psort location: cytoplasmic, score: 23 YP_001453834.1 KEGG: eci:UTI89_C0838 9.3e-145 yliG; hypothetical protein YliG; COG: COG0621 2-methylTHIoadenine synthetase; Psort location: cytoplasmic, score: 23 YP_001453835.1 KEGG: rha:RHA1_ro09047 4.3e-06 ABC peptide transporter, permease component K02033; COG: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001453836.1 KEGG: rha:RHA1_ro09047 5.0e-43 ABC peptide transporter, permease component K02033; COG: COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001453837.1 KEGG: shn:Shewana3_2650 1.1e-36 acetate kinase K00925; COG: COG0747 ABC-type dipeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001453838.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains YP_001453839.1 KEGG: stm:STM0847 5.5e-147 ybiK; putative asparaginase K01424; COG: COG1446 Asparaginase; Psort location: cytoplasmic, score: 23 YP_001453840.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum YP_001453841.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase YP_001453842.1 Psort location: nuclear, score: 23 YP_001453843.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies YP_001453844.1 KEGG: stm:STM0844 3.2e-151 pflE; putative pyruvate formate lyase activating enzyme K04069; COG: COG1180 Pyruvate-formate lyase-activating enzyme; Psort location: cytoplasmic, score: 23 YP_001453845.1 KEGG: ssn:SSO_0805 0. ybiW; putative formate acetyltransferase K00656; COG: COG1882 Pyruvate-formate lyase; Psort location: cytoplasmic, score: 23 YP_001453846.1 KEGG: eci:UTI89_C0121 1.3e-41 usp; uropathogenic specific protein K01150; COG: NOG14030 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453847.1 COG: NOG36642 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001453848.1 Psort location: cytoplasmic, score: 23 YP_001453849.1 COG: NOG36642 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001453850.1 Psort location: cytoplasmic, score: 23 YP_001453851.1 KEGG: ecp:ECP_0835 7.3e-129 putative hydrolase of the HAD superfamily K07757; COG: COG0561 Predicted hydrolases of the HAD superfamily; Psort location: cytoplasmic, score: 23 YP_001453852.1 COG: NOG06762 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453853.1 COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001453854.1 KEGG: dre:30298 0.0043 jak2b; Janus kinase 2b K04447; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001453855.1 KEGG: ssn:SSO_0800 0. putative glucosidase K01187; COG: COG1501 Alpha-glucosidases, family 31 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001453856.1 KEGG: eci:UTI89_C0824 1.9e-272 ybiT; hypothetical ABC transporter ATP-binding protein YbiT K01957; COG: COG0488 ATPase components of ABC transporters with duplicated ATPase domains; Psort location: cytoskeletal, score: 9 YP_001453857.1 KEGG: eci:UTI89_C2228 3.7e-102 erfK; hypothetical protein K00257; COG: COG1376 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001453858.1 KEGG: plt:Plut_0474 0.0023 cytochrome bd ubiquinol oxidase, subunit II K00426; COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001453859.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present YP_001453860.1 Psort location: cytoplasmic, score: 23 YP_001453861.1 KEGG: eci:UTI89_C0819 3.0e-249 ybiP; hypothetical protein YbiP K00924; COG: COG2194 Predicted membrane-associated, metal-dependent hydrolase; Psort location: endoplasmic reticulum, score: 9 YP_001453862.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains YP_001453863.1 Psort location: cytoplasmic, score: 23 YP_001453864.1 Psort location: mitochondrial, score: 23 YP_001453865.1 KEGG: pae:PA1977 4.6e-09 sensor protein GLPS; COG: COG5006 Predicted permease, DMT superfamily; Psort location: plasma membrane, score: 23 YP_001453866.1 Psort location: endoplasmic reticulum, score: 9 YP_001453867.1 Psort location: extracellular, including cell wall, score: 9 YP_001453868.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage YP_001453869.1 similar to periplasmic-binding component of ABC transporters YP_001453870.1 Psort location: nuclear, score: 23 YP_001453871.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine YP_001453872.1 similar to ATP-binding component of ABC transporters YP_001453873.1 COG: COG0668 Small-conductance mechanosensitive channel; Psort location: plasma membrane, score: 23 YP_001453874.1 KEGG: vfi:VFA1153 5.9e-79 methyltransferase; COG: COG3129 Predicted SAM-dependent methyltransferase; Psort location: cytoplasmic, score: 23 YP_001453875.1 Psort location: cytoplasmic, score: 23 YP_001453876.1 COG: NOG10254 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001453877.1 Psort location: cytoplasmic, score: 23 YP_001453878.1 KEGG: bta:538659 0.0061 LOC538659; similar to spermiogenesis associated serine/threonine kinase 22C K08811; COG: COG1734 DnaK suppressor protein; Psort location: nuclear, score: 23 YP_001453879.1 COG: NOG13870 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001453880.1 KEGG: rso:RSc0378 1.5e-50 trpD3, RS03346; putative anthranilate phosphoribosyltransferase protein K00766; COG: COG0547 Anthranilate phosphoribosyltransferase; Psort location: cytoplasmic, score: 23 YP_001453881.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: endoplasmic reticulum, score: 9 YP_001453882.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001453883.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001453884.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: cytoplasmic, score: 23 YP_001453885.1 COG: NOG23921 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001453886.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001453887.1 helicase involved in DNA repair and perhaps also replication YP_001453888.1 this helicase is not essential cell growth YP_001453889.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001453890.1 COG: COG0845 Membrane-fusion protein; Psort location: extracellular, including cell wall, score: 9 YP_001453891.1 KEGG: rru:Rru_A1792 1.0e-168 ABC transporter component K01990; COG: COG1131 ABC-type multidrug transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001453892.1 KEGG: fal:FRAAL1796 2.0e-10 putative ABC transporter ATP-binding subunit; COG: COG0842 ABC-type multidrug transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001453893.1 KEGG: fal:FRAAL1796 3.0e-11 putative ABC transporter ATP-binding subunit; COG: COG0842 ABC-type multidrug transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001453894.1 COG: NOG09757 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001453895.1 KEGG: eci:UTI89_C0791 1.4e-123 ybhP; putative DNase; COG: COG3568 Metal-dependent hydrolase; Psort location: mitochondrial, score: 23 YP_001453896.1 KEGG: stt:t2076 2.1e-209 ybhO; putative phospholipase K06132; COG: COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes; Psort location: cytoplasmic, score: 23 YP_001453897.1 COG: COG0392 Predicted integral membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001453898.1 COG: COG0670 Integral membrane protein, interacts with FtsH; Psort location: plasma membrane, score: 23 YP_001453899.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_001453900.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_001453901.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_001453902.1 KEGG: mtu:Rv0984 1.5e-11 moaB2; possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-A-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD); COG: COG0521 Molybdopterin biosynthesis enzymes; Psort location: cytoplasmic, score: 23 YP_001453903.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_001453904.1 KEGG: mth:MTH1018 6.0e-06 LPPG:FO 2-phopspho-L-lactate transferase K00924; COG: COG0391 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001453905.1 Psort location: mitochondrial, score: 23 YP_001453906.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001453907.1 Psort location: cytoplasmic, score: 23 YP_001453908.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_001453909.1 putative methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth YP_001453910.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine YP_001453911.1 KEGG: ecc:c0855 7.8e-180 bioB; biotin synthase K01012; COG: COG0502 Biotin synthase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001453912.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate YP_001453913.1 YbhB; similar to rat and human kinase inhibitory proteins YP_001453914.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_001453915.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_001453916.1 KEGG: reh:H16_A3019 8.3e-57 hutC; histidine utilization repressor; COG: COG2188 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001453917.1 catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate YP_001453918.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_001453919.1 Psort location: cytoplasmic, score: 23 YP_001453920.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family YP_001453921.1 KEGG: ecp:ECP_0784 0. aconitate hydratase K01680; COG: COG1048 Aconitase A; Psort location: cytoplasmic, score: 23 YP_001453922.1 KEGG: eca:ECA4210 0.0082 wecA, rfe; undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase K02851; COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001453923.1 Psort location: nuclear, score: 23 YP_001453924.1 COG: COG2828 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001453925.1 KEGG: shn:Shewana3_3435 4.1e-23 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001453926.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate YP_001453927.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily YP_001453928.1 Part of the ABC transporter complex modABC involved in molybdenum import YP_001453929.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE YP_001453930.1 with ModCB is involved in the high-affinity transport of molybdate YP_001453931.1 COG: NOG17580 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001453932.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons YP_001453933.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum YP_001453934.1 KEGG: ecs:ECs0787 3.7e-180 UDP-glucose 4-epimerase K01784; COG: COG1087 UDP-glucose 4-epimerase; Psort location: cytoplasmic, score: 23 YP_001453935.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P YP_001453936.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_001453937.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose YP_001453938.1 Psort location: cytoplasmic, score: 23 YP_001453939.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_001453940.1 KEGG: stm:STM0771 1.2e-105 putative ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component K02013; COG: COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001453941.1 COG: COG0609 ABC-type Fe3+-siderophore transport system, permease component; Psort location: plasma membrane, score: 23 YP_001453942.1 COG: COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001453943.1 COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: extracellular, including cell wall, score: 9 YP_001453944.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_001453945.1 KEGG: cal:orf19.4072 6.5e-05 HYR10; similar to cell surface flocculin K01186; COG: NOG09755 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001453946.1 involved in zinc efflux across the cytoplasmic membrane YP_001453947.1 COG: COG3201 Nicotinamide mononucleotide transporter; Psort location: plasma membrane, score: 23 YP_001453948.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_001453949.1 Psort location: mitochondrial, score: 23 YP_001453950.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity YP_001453952.1 KEGG: bxe:Bxe_A4171 1.2e-08 putative cytochrome c oxidase K00403; COG: COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; Psort location: nuclear, score: 23 YP_001453953.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_001453954.1 KEGG: eci:UTI89_C0735 7.2e-58 tolA; membrane spanning protein TolA K03646; COG: COG3064 Membrane protein involved in colicin uptake; Psort location: nuclear, score: 23 YP_001453955.1 KEGG: eci:UTI89_C0735 1.0e-83 tolA; membrane spanning protein TolA K03646; COG: COG3064 Membrane protein involved in colicin uptake; Psort location: nuclear, score: 23 YP_001453956.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_001453957.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_001453958.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components YP_001453959.1 COG: COG3790 Predicted membrane protein; Psort location: extracellular, including cell wall, score: 23 YP_001453960.1 COG: COG4890 Predicted outer membrane lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001453961.1 Psort location: nuclear, score: 23 YP_001453962.1 KEGG: spt:SPA2002 3.1e-201 cydB; cytochrome d ubiquinol oxidase subunit II K00426; COG: COG1294 Cytochrome bd-type quinol oxidase, subunit 2; Psort location: plasma membrane, score: 23 YP_001453963.1 KEGG: stm:STM0740 2.8e-269 cydA; cytochrome d terminal oxidase, polypeptide subunit I K00425; COG: COG1271 Cytochrome bd-type quinol oxidase, subunit 1; Psort location: plasma membrane, score: 23 YP_001453964.1 Psort location: nuclear, score: 23 YP_001453965.1 Psort location: cytoplasmic, score: 23 YP_001453966.1 KEGG: lmf:LMOf2365_0421 3.1e-144 glycosyl hydrolase, family 38 K01191; COG: COG0383 Alpha-mannosidase; Psort location: cytoplasmic, score: 23 YP_001453967.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_001453968.1 regulates the succiny-lCoA synthetase operon YP_001453969.1 converts methylaspartate to L-glutamate YP_001453970.1 KEGG: fnu:FN1854 7.2e-58 methylaspartate mutase K01846; COG: NOG07779 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453971.1 KEGG: tde:TDE2236 2.2e-150 glmE; methylaspartate mutase, E subunit K01846; COG: COG4865 Glutamate mutase epsilon subunit; Psort location: cytoplasmic, score: 23 YP_001453972.1 KEGG: ece:Z0892 4.3e-211 putative methylaspartate ammonia-lyase K04835; COG: COG3799 Methylaspartate ammonia-lyase; Psort location: cytoplasmic, score: 23 YP_001453973.1 COG: NOG07992 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453974.1 COG: NOG19635 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453975.1 Psort location: cytoplasmic, score: 23 YP_001453976.1 KEGG: eci:UTI89_C4668 5.6e-67 gltP; glutamate-aspartate symport protein K03309; COG: COG1301 Na+/H+-dicarboxylate symporters; Psort location: plasma membrane, score: 23 YP_001453977.1 KEGG: ece:Z0887 7.8e-267 putative fumarate hydratase K01676; COG: COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain; Psort location: cytoplasmic, score: 23 YP_001453978.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide YP_001453979.1 Psort location: cytoplasmic, score: 23 YP_001453980.1 KEGG: shn:Shewana3_3435 0.0078 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001453981.1 Psort location: cytoplasmic, score: 23 YP_001453982.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_001453983.1 catalyzes the interconversion of succinyl-CoA and succinate YP_001453984.1 Psort location: cytoplasmic, score: 23 YP_001453985.1 Psort location: nuclear, score: 23 YP_001453986.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_001453987.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_001453988.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_001453989.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_001453990.1 KEGG: sty:STY0776 2.0e-53 sdhD; succinate dehydrogenase hydrophobic membrane anchor protein K00242; COG: COG2142 Succinate dehydrogenase, hydrophobic anchor subunit; Psort location: endoplasmic reticulum, score: 9 YP_001453991.1 KEGG: ecc:c0798 5.8e-65 sdhC; succinate dehydrogenase cytochrome b-556 subunit K00241; COG: COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit; Psort location: endoplasmic reticulum, score: 9 YP_001453992.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_001453993.1 KEGG: eci:UTI89_C0121 7.2e-209 usp; uropathogenic specific protein K01150; COG: COG5529 Pyocin large subunit; Psort location: cytoplasmic, score: 23 YP_001453994.1 COG: NOG17103 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453995.1 Psort location: cytoplasmic, score: 23 YP_001453996.1 COG: NOG17103 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001453997.1 COG: NOG26283 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001453998.1 COG: COG3180 Putative ammonia monooxygenase; Psort location: endoplasmic reticulum, score: 9 YP_001453999.1 COG: NOG06222 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454000.1 KEGG: sgl:SG2119 1.2e-94 putative glucuronyl hydrolase K01238; COG: NOG09941 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454001.1 KEGG: eci:UTI89_C3355 1.2e-06 nupG; transport of nucleosides, permease protein K03289; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001454002.1 COG: COG4289 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001454003.1 KEGG: bcz:BCZK3497 1.9e-13 adaA; transcriptional regulator, AraC family K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001454004.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity YP_001454005.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline YP_001454006.1 COG: COG3817 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001454007.1 COG: COG3819 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001454008.1 COG: COG1540 Uncharacterized proteins, homologs of lactam utilization protein B; Psort location: cytoplasmic, score: 23 YP_001454009.1 KEGG: eci:UTI89_C0710 1.1e-148 ybgK; hypothetical protein K01941; COG: COG1984 Allophanate hydrolase subunit 2; Psort location: cytoplasmic, score: 23 YP_001454010.1 KEGG: eci:UTI89_C0709 7.1e-99 ybgJ; hypothetical protein YbgJ K01457; COG: COG2049 Allophanate hydrolase subunit 1; Psort location: cytoplasmic, score: 23 YP_001454011.1 COG: COG0327 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001454012.1 KEGG: ace:Acel_1973 4.1e-05 V-type H(+)-translocating pyrophosphatase K01507; COG: COG3104 Dipeptide/tripeptide permease; Psort location: plasma membrane, score: 23 YP_001454013.1 Psort location: mitochondrial, score: 23 YP_001454014.1 COG: NOG13868 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454015.1 Psort location: mitochondrial, score: 23 YP_001454016.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_001454017.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_001454018.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex YP_001454019.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein YP_001454020.1 response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport YP_001454021.1 Psort location: golgi, score: 9 YP_001454022.1 KEGG: ssn:SSO_0644 0. speF; orniTHIne decarboxylase isozyme, inducible K01581; COG: COG1982 Arginine/lysine/orniTHIne decarboxylases; Psort location: cytoplasmic, score: 23 YP_001454023.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system YP_001454024.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_001454025.1 negative modulator of the initiation of chromosome replication YP_001454026.1 KEGG: ecc:c0773 3.8e-123 ybfF; putative esterase/lipase YbfF; COG: COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Psort location: cytoplasmic, score: 23 YP_001454027.1 COG: NOG13544 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001454028.1 Psort location: mitochondrial, score: 23 YP_001454029.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001454030.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer YP_001454031.1 COG: NOG11319 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454032.1 KEGG: psp:PSPPH_3782 8.6e-14 porin D; COG: NOG06287 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454033.1 Psort location: cytoplasmic, score: 23 YP_001454034.1 Psort location: extracellular, including cell wall, score: 9 YP_001454035.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001454036.1 Psort location: nuclear, score: 23 YP_001454037.1 COG: KOG2798 Putative trehalase; Psort location: cytoplasmic, score: 23 YP_001454038.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001454039.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate YP_001454040.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate YP_001454041.1 KEGG: eci:UTI89_C0670 7.9e-203 nagC; transcriptional repressor of nag (N-acetylglucosamine) operon K02565; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: cytoplasmic, score: 23 YP_001454042.1 KEGG: eci:UTI89_C0669 7.3e-129 nagD; N-acetylglucosamine metabolism K02566; COG: COG0647 Predicted sugar phosphatases of the HAD superfamily; Psort location: cytoplasmic, score: 23 YP_001454043.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP YP_001454044.1 Psort location: mitochondrial, score: 23 YP_001454047.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q YP_001454048.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001454049.1 KEGG: reh:H16_A0527 2.6e-85 phoH; phosphate starvation-inducible protein PhoH,predicted ATPase; COG: COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001454050.1 KEGG: dps:DP1605 9.8e-10 probable pyridoxal phosphate biosynthetic protein K03474; COG: COG0319 Predicted metal-dependent hydrolase; Psort location: cytoplasmic, score: 23 YP_001454051.1 KEGG: eci:UTI89_C0656 6.8e-149 ybeX; putative transport protein K06189; COG: COG4535 Putative Mg2+ and Co2+ transporter CorC; Psort location: cytoplasmic, score: 23 YP_001454052.1 Transfers the fatty acyl group on membrane lipoproteins YP_001454053.1 KEGG: bur:Bcep18194_A4762 3.7e-22 ABC amino acid transporter, periplasmic ligand binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: nuclear, score: 23 YP_001454054.1 KEGG: eca:ECA0855 1.0e-19 ABC transporter permease protein K02028; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001454055.1 KEGG: ret:RHE_PF00254 3.3e-26 glnP, glnQ; glutamine ABC transporter, ATP-binding protein K02028; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001454056.1 KEGG: eci:UTI89_C0648 1.5e-119 gltL; ATP-binding protein of glutamate/aspartate transport system K02028; COG: COG1126 ABC-type polar amino acid transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001454057.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific YP_001454058.1 COG: NOG08739 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454059.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001454060.1 COG: COG2980 Rare lipoprotein B; Psort location: nuclear, score: 23 YP_001454061.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_001454062.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_001454063.1 cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase YP_001454064.1 KEGG: stm:STM0643 3.9e-91 cobC; alpha ribazole-5'-P phosphatase in cobalamin synthesis K02226; COG: COG0406 Fructose-2,6-bisphosphatase; Psort location: cytoplasmic, score: 23 YP_001454065.1 KEGG: bba:Bd3846 2.6e-09 probable nicotinate-nucleotide adenylyltransferase K00969; COG: COG0799 Uncharacterized homolog of plant Iojap protein; Psort location: cytoplasmic, score: 23 YP_001454066.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_001454067.1 KEGG: eci:UTI89_C0637 0. mrdA; cell elongation, e phase; peptidoglycan synthetase; penicillin-binding protein 2 K05515; COG: COG0768 Cell division protein FtsI/penicillin-binding protein 2; Psort location: cytoplasmic, score: 23 YP_001454068.1 COG: COG0772 Bacterial cell division membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001454069.1 KEGG: sco:SCO2181 1.2e-05 SC5F7.20, sucB; putative dihydrolipoamide succinyltransferase K00658; COG: COG0797 Lipoproteins; Psort location: extracellular, including cell wall, score: 9 YP_001454070.1 Psort location: cytoplasmic, score: 23 YP_001454071.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors YP_001454072.1 KEGG: dme:Dmel_CG10495 0.0086 CG10495 K05545; COG: COG2921 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001454073.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_001454074.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001454075.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001454076.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_001454077.1 KEGG: eci:UTI89_C0629 1.2e-112 ybeM; putative amidase K01501; COG: COG0388 Predicted amidohydrolase; Psort location: endoplasmic reticulum, score: 9 YP_001454078.1 COG: COG0239 Integral membrane protein possibly involved in chromosome condensation; Psort location: mitochondrial, score: 23 YP_001454079.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator YP_001454080.1 catalyzes the transfer of palmitate to lipid A YP_001454081.1 Psort location: cytoplasmic, score: 23 YP_001454082.1 responsible for the transport of C4-dicarboxylates during anaerobic growth YP_001454083.1 Psort location: mitochondrial, score: 23 YP_001454084.1 regulates the expression of citAB in citrate fermentation YP_001454085.1 KEGG: stt:t2242 3.2e-270 dpiB; sensor kinase DpiB K07700; COG: COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism; Psort location: endoplasmic reticulum, score: 9 YP_001454086.1 KEGG: stm:STM0624 1.3e-175 citC; citrate lyase synthetase K01910; COG: COG3053 Citrate lyase synthetase; Psort location: cytoplasmic, score: 23 YP_001454087.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate YP_001454088.1 KEGG: stm:STM0622 8.9e-140 citE; citrate lyase beta chain (acyl lyase subunit) K01660:K01644; COG: COG2301 Citrate lyase beta subunit; Psort location: cytoplasmic, score: 23 YP_001454089.1 KEGG: stm:STM0621 5.9e-246 citF; bifunctional citrate lyase alpha chain/citrate-ACP transferase K01037:K01643; COG: COG3051 Citrate lyase, alpha subunit; Psort location: cytoplasmic, score: 23 YP_001454090.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate YP_001454091.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA YP_001454092.1 COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001454093.1 KEGG: ecc:c0699 7.9e-116 rna; ribonuclease I precursor K01169; COG: COG3719 Ribonuclease I; Psort location: extracellular, including cell wall, score: 9 YP_001454094.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation YP_001454095.1 Psort location: cytoplasmic, score: 23 YP_001454096.1 KEGG: eco:b0606 2.1e-266 ahpF; alkyl hydroperoxide reductase subunit, FAD/NAD(P)-binding, detoxification of hydroperoxides K03387; COG: COG3634 Alkyl hydroperoxide reductase, large subunit; Psort location: cytoplasmic, score: 23 YP_001454097.1 Psort location: nuclear, score: 23 YP_001454098.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate YP_001454099.1 Psort location: cytoplasmic, score: 23 YP_001454100.1 Involved in disulfide bond formation YP_001454101.1 KEGG: shn:Shewana3_3435 9.4e-05 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: nuclear, score: 23 YP_001454102.1 KEGG: eci:UTI89_C2238 1.5e-146 ibrA; hypothetical protein YbdN K00390; COG: COG3969 Predicted phosphoadenosine phosphosulfate sulfotransferase; Psort location: cytoplasmic, score: 23 YP_001454103.1 COG: COG1475 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001454104.1 catalyzes the transfer of an amino moiety YP_001454105.1 member of the iron-containing alcohol dehydrogenase family; unknown function YP_001454106.1 Psort location: cytoplasmic, score: 23 YP_001454107.1 COG: COG2879 Uncharacterized small protein; Psort location: cytoplasmic, score: 23 YP_001454108.1 KEGG: xtr:3283503 0.0075 ND6; NADH dehydrogenase subunit 6 K03884; COG: COG1966 Carbon starvation protein, predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001454109.1 KEGG: eco:b0597 1.3e-67 ybdB; hypothetical protein; COG: COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; Psort location: cytoplasmic, score: 23 YP_001454110.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin YP_001454111.1 KEGG: spt:SPA2137 1.4e-143 entB; isochorismatase K01252; COG: COG3433 Aryl carrier domain; Psort location: cytoplasmic, score: 23 YP_001454112.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate YP_001454113.1 KEGG: stm:STM0595 3.5e-184 entC; isochorismate synthetase, enterochelin biosynthesis K02361; COG: COG1169 Isochorismate synthase; Psort location: cytoplasmic, score: 23 YP_001454114.1 with FepCDG is involved in the transport of ferric enterobactin YP_001454115.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters YP_001454116.1 with FepBCG is involved in the transport of ferric enterobactin YP_001454117.1 with FepBCD is involved in the transport of ferric enterobactin YP_001454118.1 with FepBDE is involved in the transport of ferric enterobactin YP_001454119.1 part of the ferric enterobactin transport system; necessary for enetrobactin uptake YP_001454120.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin YP_001454121.1 COG: COG3251 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001454122.1 KEGG: btk:BT9727_2470 3.8e-15 probable esterase K07214; COG: COG2382 Enterochelin esterase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001454123.1 Psort location: nuclear, score: 23 YP_001454124.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space YP_001454125.1 KEGG: sec:SC0615 2.3e-68 entD; enterochelin synthetase, component D (phoshpantetheinyltransferase) K02362; COG: COG2977 Phosphopantetheinyl transferase component of siderophore synthetase; Psort location: mitochondrial, score: 23 YP_001454126.1 proton-motive-force-driven choline transporter YP_001454127.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes YP_001454128.1 catalyzes the formation of betaine from betaine aldehyde YP_001454129.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine YP_001454130.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity YP_001454131.1 Psort location: nuclear, score: 23 YP_001454132.1 Psort location: endoplasmic reticulum, score: 9 YP_001454133.1 KEGG: btk:BT9727_2470 6.1e-22 probable esterase K07214; COG: COG2382 Enterochelin esterase and related enzymes; Psort location: extracellular, including cell wall, score: 9 YP_001454134.1 KEGG: sgl:SG1838 1.1e-08 putative mannonate dehydratase K01686; COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: extracellular, including cell wall, score: 9 YP_001454135.1 Psort location: mitochondrial, score: 23 YP_001454136.1 KEGG: bcz:BCZK3497 5.1e-09 adaA; transcriptional regulator, AraC family K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: nuclear, score: 23 YP_001454137.1 KEGG: spa:M6_Spy0202 0.00020 metal-dependent hydrolase; COG: COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold; Psort location: extracellular, including cell wall, score: 9 YP_001454138.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001454139.1 COG: COG2315 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001454140.1 Psort location: cytoplasmic, score: 23 YP_001454141.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive YP_001454142.1 COG: COG1396 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001454143.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001454144.1 COG: COG0668 Small-conductance mechanosensitive channel; Psort location: plasma membrane, score: 23 YP_001454145.1 KEGG: efa:EF1922 1.4e-13 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001454146.1 KEGG: bme:BMEI1388 8.0e-36 oxidoreductase K00100; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001454147.1 KEGG: hma:rrnAC0265 2.6e-07 apl; AP-endonuclease/AP-lyase K01151:K01741; COG: COG1082 Sugar phosphate isomerases/epimerases; Psort location: cytoplasmic, score: 23 YP_001454148.1 KEGG: eci:UTI89_C3355 3.4e-51 nupG; transport of nucleosides, permease protein K03289; COG: NOG06278 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001454149.1 Psort location: nuclear, score: 23 YP_001454150.1 KEGG: eci:UTI89_C0120 1.7e-159 aroP; aromatic amino acid transport protein AroP K03293; COG: COG1113 Gamma-aminobutyrate permease and related permeases; Psort location: plasma membrane, score: 23 YP_001454151.1 KEGG: dra:DRA0202 0.00030 superoxide dismutase (sodC), Cu-Zn family K04565; COG: COG3391 Uncharacterized conserved protein; Psort location: endoplasmic reticulum, score: 23 YP_001454152.1 KEGG: dre:562769 1.9e-06 LOC562769; similar to Serine/threonine-protein kinase 10 (Lymphocyte-oriented kinase) K08837; COG: COG1076 DnaJ-domain-containing proteins 1; Psort location: nuclear, score: 23 YP_001454153.1 COG: COG5581 Predicted glycosyltransferase; Psort location: cytoskeletal, score: 9 YP_001454154.1 Psort location: cytoplasmic, score: 23 YP_001454155.1 Psort location: cytoplasmic, score: 23 YP_001454156.1 KEGG: eci:UTI89_C2351 1.8e-59 yegO; hypothetical protein YegO K07789; COG: COG3696 Putative silver efflux pump; Psort location: plasma membrane, score: 23 YP_001454157.1 with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver YP_001454158.1 COG: COG5569 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001454159.1 with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver YP_001454160.1 response regulator in two-component regulatory system with CusS; regulates the copper efflux system YP_001454161.1 KEGG: ecs:ECs0608 1.7e-200 putative 2-component sensor protein K07644; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001454162.1 Psort location: cytoplasmic, score: 23 YP_001454163.1 COG: COG2771 DNA-binding HTH domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001454164.1 COG: COG2200 FOG: EAL domain; Psort location: cytoplasmic, score: 23 YP_001454165.1 COG: NOG24886 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001454166.1 activates the production of the major fimbrae protein FimA YP_001454167.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001454168.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001454169.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001454170.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001454171.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001454172.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: cytoplasmic, score: 23 YP_001454173.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_001454174.1 COG: COG2501 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001454175.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001454176.1 Psort location: cytoplasmic, score: 23 YP_001454177.1 KEGG: sty:STY0584 2.9e-86 ppiB; peptidyl-prolyl cis-trans isomerase B K03768; COG: COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; Psort location: cytoplasmic, score: 23 YP_001454178.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine YP_001454179.1 KEGG: ecs:ECs0585 1.0e-81 phosphoribosylaminoimidazole carboxylase catalytic subunit K01588; COG: COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; Psort location: cytoplasmic, score: 23 YP_001454180.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_001454181.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA YP_001454182.1 KEGG: baa:BA_0884 6.6e-48 binding-protein-dependent transport systems inner membrane component K00294; COG: COG2011 ABC-type metal ion transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001454183.1 KEGG: rru:Rru_A0788 3.3e-78 ABC transporter component K06020; COG: COG1135 ABC-type metal ion transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001454184.1 COG: COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen; Psort location: extracellular, including cell wall, score: 9 YP_001454185.1 Psort location: nuclear, score: 23 YP_001454186.1 Psort location: cytoplasmic, score: 23 YP_001454187.1 COG: COG3203 Outer membrane protein (porin); Psort location: cytoplasmic, score: 23 YP_001454188.1 COG: COG3127 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component; Psort location: plasma membrane, score: 23 YP_001454189.1 KEGG: pen:PSEEN1885 1.4e-61 ABC transporter, ATP-binding protein; COG: COG4181 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component; Psort location: cytoplasmic, score: 23 YP_001454190.1 KEGG: eci:UTI89_C0529 3.4e-99 tesA; acyl-CoA THIoesterase I precursor K01048:K01076; COG: COG2755 Lysophospholipase L1 and related esterases; Psort location: extracellular, including cell wall, score: 9 YP_001454191.1 KEGG: ecc:c0614 1.1e-123 ybbO; short chain dehydrogenase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001454192.1 KEGG: eci:UTI89_C0527 1.5e-137 ybbN; putative THIoredoxin-like protein K05838; COG: COG3118 Thioredoxin domain-containing protein; Psort location: cytoplasmic, score: 23 YP_001454193.1 COG: COG0390 ABC-type uncharacterized transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001454194.1 KEGG: lpn:lpg1141 1.6e-28 spermidine/putrescine ABC transporter, ATP-binding protein PotA K02052; COG: COG4619 ABC-type uncharacterized transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001454195.1 KEGG: reh:H16_A2036 1.7e-58 membrane protease subunits, stomatin/prohibitin homologs K01423; COG: COG0330 Membrane protease subunits, stomatin/prohibitin homologs; Psort location: endoplasmic reticulum, score: 9 YP_001454196.1 COG: COG1585 Membrane protein implicated in regulation of membrane protease activity; Psort location: endoplasmic reticulum, score: 9 YP_001454197.1 activator of copper-responsive regulon genes YP_001454198.1 KEGG: shn:Shewana3_3063 4.6e-07 phosphatidylglycerophosphatase K01094; COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: extracellular, including cell wall, score: 9 YP_001454199.1 COG: COG4558 ABC-type hemin transport system, periplasmic component; Psort location: endoplasmic reticulum, score: 9 YP_001454200.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001454201.1 KEGG: hdu:HD0037 6.4e-22 chuW; probable oxygen-independent coproporphyrinogen III oxidase K02495; COG: COG3721 Putative heme iron utilization protein; Psort location: cytoplasmic, score: 23 YP_001454202.1 KEGG: rha:RHA1_ro02137 0.00014 probable nucleoside-diphosphate-sugar epimerase K01820; COG: COG0702 Predicted nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001454203.1 COG: COG0609 ABC-type Fe3+-siderophore transport system, permease component; Psort location: endoplasmic reticulum, score: 23 YP_001454204.1 with HmuTU is involved in the transport of hemin YP_001454205.1 KEGG: cal:orf19.2425 5.6e-07 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001454206.1 KEGG: msm:MSMEG_3095 0.0013 D-ribose-binding periplasmic protein; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001454207.1 KEGG: tfu:Tfu_2581 1.5e-32 inosine-uridine preferring nucleoside hydrolase K01239; COG: COG1957 Inosine-uridine nucleoside N-ribohydrolase; Psort location: cytoplasmic, score: 23 YP_001454208.1 KEGG: oih:OB0089 2.7e-28 cation-transporting ATPase K07507; COG: COG1285 Uncharacterized membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001454209.1 KEGG: sty:STY0544 0. ybaR; copper-transporting ATPase K01533; COG: COG2217 Cation transport ATPase; Psort location: endoplasmic reticulum, score: 9 YP_001454210.1 COG: COG3735 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001454211.1 KEGG: gme:Gmet_1354 0.0050 prolyl-tRNA synthetase K01881; COG: COG2606 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001454212.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides YP_001454213.1 KEGG: pca:Pcar_2776 0.00019 2-acyl-glycerophospho-ethanolamine acyltransferase K05939:K01909; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001454214.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein YP_001454215.1 KEGG: stm:STM0491 1.1e-228 gsk; inosine-guanosine kinase K00892; COG: COG0524 Sugar kinases, ribokinase family; Psort location: mitochondrial, score: 23 YP_001454216.1 KEGG: spt:SPA2232 1.8e-139 aes; acetyl esterase K01066; COG: COG0657 Esterase/lipase; Psort location: cytoplasmic, score: 23 YP_001454217.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_001454218.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_001454219.1 molecular chaperone YP_001454220.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001454221.1 COG: COG0718 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001454222.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_001454223.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_001454224.1 COG: COG2832 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001454225.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks YP_001454226.1 COG: NOG18531 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001454227.1 Psort location: mitochondrial, score: 23 YP_001454228.1 COG: COG5464 Uncharacterized conserved protein; Psort location: nuclear, score: 23 YP_001454229.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS YP_001454230.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine YP_001454231.1 KEGG: saz:Sama_0326 0.0047 phosphopantothenoylcysteine decarboxylase, phosphopantothenate--cysteine ligase K01598:K01922; COG: COG0845 Membrane-fusion protein; Psort location: extracellular, including cell wall, score: 9 YP_001454232.1 KEGG: eci:UTI89_C2351 2.4e-107 yegO; hypothetical protein YegO K07789; COG: COG0841 Cation/multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001454233.1 COG: NOG09846 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001454234.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins YP_001454235.1 KEGG: sty:STY0515 1.0e-83 maA; maltose O-acetyltransferase K00661; COG: COG0110 Acetyltransferase (isoleucine patch superfamily); Psort location: cytoplasmic, score: 23 YP_001454236.1 Psort location: cytoplasmic, score: 23 YP_001454237.1 COG: NOG07873 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 23 YP_001454238.1 COG: COG0257 Ribosomal protein L36; Psort location: nuclear, score: 23 YP_001454239.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001454240.1 KEGG: vfi:VF0494 1.2e-31 sensory transduction protein kinase; COG: COG4943 Predicted signal transduction protein containing sensor and EAL domains; Psort location: endoplasmic reticulum, score: 9 YP_001454241.1 KEGG: ssn:SSO_0443 2.3e-54 ybaA; hypothetical protein K01077; COG: COG5507 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001454242.1 COG: COG2364 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001454243.1 KEGG: rha:RHA1_ro05556 2.4e-98 transcriptional regulator/aminotransferase; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: mitochondrial, score: 23 YP_001454244.1 Psort location: cytoplasmic, score: 23 YP_001454245.1 COG: NOG30699 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001454246.1 KEGG: eci:UTI89_C0482 1.2e-46 ybaZ; hypothetical protein YbaZ K07443; COG: COG3695 Predicted methylated DNA-protein cysteine methyltransferase; Psort location: cytoplasmic, score: 23 YP_001454247.1 COG: COG3126 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001454248.1 KEGG: sec:SC0507 1.1e-139 tesB; acyl-CoA THIoesterase II K01076; COG: COG1946 Acyl-CoA THIoesterase; Psort location: cytoplasmic, score: 23 YP_001454249.1 KEGG: ter:Tery_3993 2.5e-36 adenylate/guanylate cyclase K01769; COG: COG0004 Ammonia permease; Psort location: plasma membrane, score: 23 YP_001454250.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia. YP_001454251.1 Psort location: nuclear, score: 23 YP_001454252.1 KEGG: cch:Cag_0453 1.5e-73 ATPase K06147; COG: COG1132 ABC-type multidrug transport system, ATPase and permease components; Psort location: endoplasmic reticulum, score: 9 YP_001454253.1 KEGG: reh:H16_A0776 1.9e-80 ABC-type transporter, ATPase and permease components: Prot2E family; COG: COG1132 ABC-type multidrug transport system, ATPase and permease components; Psort location: endoplasmic reticulum, score: 9 YP_001454254.1 COG: COG1522 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001454255.1 KEGG: sec:SC0500 8.5e-174 putative cysteine synthase/cystaTHIonine beta-synthase K01738; COG: COG0031 Cysteine synthase; Psort location: cytoplasmic, score: 23 YP_001454256.1 KEGG: aha:AHA_0482 6.3e-20 phosphatase YidA K01112; COG: COG0561 Predicted hydrolases of the HAD superfamily; Psort location: cytoplasmic, score: 23 YP_001454257.1 COG: COG4533 ABC-type uncharacterized transport system, periplasmic component; Psort location: cytoplasmic, score: 23 YP_001454258.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His YP_001454259.1 KEGG: gbe:GbCGDNIH1_1102 1.3e-10 short-chain acyl-CoA hydrolase; COG: COG0824 Predicted THIoesterase; Psort location: cytoplasmic, score: 23 YP_001454260.1 KEGG: bur:Bcep18194_A5099 0.00019 RNA binding S1; COG: COG1555 DNA uptake protein and related DNA-binding proteins; Psort location: extracellular, including cell wall, score: 9 YP_001454261.1 KEGG: sbo:SBO_0335 1.0e-296 ybaU; putative protease maturation protein K03770; COG: COG0760 Parvulin-like peptidyl-prolyl isomerase; Psort location: endoplasmic reticulum, score: 9 YP_001454262.1 histone-like DNA-binding protein YP_001454263.1 KEGG: stm:STM0450 0. lon; ATP-dependent protease Lon K01338; COG: COG0466 ATP-dependent Lon protease, bacterial type; Psort location: cytoplasmic, score: 23 YP_001454264.1 binds and unfolds substrates as part of the ClpXP protease YP_001454265.1 KEGG: sec:SC0490 7.7e-125 clpP; proteolytic subunit of ClpA-ClpP ATP-dependent serine protease, heat shock protein F215 K01358; COG: COG0740 Protease subunit of ATP-dependent Clp proteases; Psort location: cytoplasmic, score: 23 YP_001454266.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001454267.1 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress YP_001454268.1 Psort location: nuclear, score: 23 YP_001454269.1 COG: COG3056 Uncharacterized lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001454270.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein YP_001454271.1 KEGG: ecc:c0543 4.6e-166 cyoA; ubiquinol oxidase polypeptide II precursor K02297; COG: COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2; Psort location: endoplasmic reticulum, score: 9 YP_001454272.1 KEGG: stt:t2418 0. cyoB; cytochrome o ubiquinol oxidase subunit I K02298; COG: COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1; Psort location: plasma membrane, score: 23 YP_001454273.1 KEGG: sty:STY0483 5.6e-106 cyoC; cytochrome o ubiquinol oxidase subunit III K02299; COG: COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3; Psort location: endoplasmic reticulum, score: 9 YP_001454274.1 KEGG: eci:UTI89_C0452 7.9e-52 cyoD; cytochrome o ubiquinol oxidase protein CyoD K02300; COG: COG3125 Heme/copper-type cytochrome/quinol oxidase, subunit 4; Psort location: endoplasmic reticulum, score: 9 YP_001454275.1 converts protoheme IX and farnesyl diphosphate to heme O YP_001454276.1 KEGG: shn:Shewana3_1692 1.8e-08 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001454277.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_001454278.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis YP_001454279.1 KEGG: eci:UTI89_C0447 2.6e-94 THIJ; 4-methyl-5(B-hydroxyethyl)-THIazole monophosphate biosynthesis enzyme K03152; COG: COG0693 Putative intracellular protease/amidase; Psort location: endoplasmic reticulum, score: 9 YP_001454280.1 Required for the synthesis of the thiazole moiety YP_001454281.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_001454282.1 KEGG: sty:STY0462 2.8e-143 ispA; geranyltranstransferase K00795; COG: COG0142 Geranylgeranyl pyrophosphate synthase; Psort location: cytoplasmic, score: 23 YP_001454283.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001454284.1 KEGG: eco:b0419 1.9e-153 yajO; predicted oxidoreductase, NAD(P)-binding; COG: COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001454285.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate YP_001454286.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP YP_001454287.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_001454288.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_001454289.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil YP_001454290.1 KEGG: eci:UTI89_C0435 5.2e-48 ybaD; hypothetical protein K07738; COG: COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains; Psort location: nuclear, score: 23 YP_001454291.1 COG: NOG07872 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454292.1 COG: COG3248 Nucleoside-binding outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001454293.1 COG: NOG13275 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001454294.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_001454295.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_001454296.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_001454297.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_001454298.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_001454299.1 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP YP_001454300.1 KEGG: stm:STM0402 2.0e-101 putative THIol - alkyl hydroperoxide reductase K03386; COG: COG0450 Peroxiredoxin; Psort location: cytoplasmic, score: 23 YP_001454301.1 COG: NOG14010 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001454302.1 KEGG: aeh:Mlg_0022 4.7e-05 cytochrome c biogenesis protein, transmembrane region K04084; COG: COG5373 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001454303.1 Psort location: endoplasmic reticulum, score: 9 YP_001454304.1 Psort location: mitochondrial, score: 23 YP_001454305.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001454306.1 KEGG: ecj:JW0393 0. malZ; maltodextrin glucosidase K01187; COG: COG0366 Glycosidases; Psort location: cytoplasmic, score: 23 YP_001454307.1 Psort location: nuclear, score: 23 YP_001454308.1 Psort location: cytoplasmic, score: 23 YP_001454309.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation YP_001454310.1 COG: COG1114 Branched-chain amino acid permeases; Psort location: plasma membrane, score: 23 YP_001454311.1 Psort location: cytoplasmic, score: 23 YP_001454312.1 Psort location: mitochondrial, score: 23 YP_001454313.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB YP_001454314.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB YP_001454315.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity YP_001454316.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity YP_001454317.1 Psort location: mitochondrial, score: 23 YP_001454318.1 Psort location: mitochondrial, score: 23 YP_001454319.1 KEGG: rru:Rru_A2630 3.7e-86 ROK K00885; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: cytoplasmic, score: 23 YP_001454320.1 Required for efficient pilin antigenic variation YP_001454321.1 Psort location: mitochondrial, score: 23 YP_001454322.1 COG: COG3123 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001454323.1 COG: NOG06193 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001454324.1 COG: NOG13867 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001454325.1 KEGG: spt:SPA2335 4.1e-64 aroL; shikimate kinase II K00891; COG: COG0703 Shikimate kinase; Psort location: cytoplasmic, score: 23 YP_001454326.1 COG: COG1671 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001454327.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_001454328.1 catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis YP_001454329.1 COG: NOG17162 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001454330.1 KEGG: sbo:SBO_0278 8.9e-227 phoA; alkaline phosphatase K01077; COG: COG1785 Alkaline phosphatase; Psort location: extracellular, including cell wall, score: 9 YP_001454331.1 COG: NOG14126 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454332.1 Psort location: cytoplasmic, score: 23 YP_001454333.1 KEGG: efa:EF1922 4.4e-07 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001454334.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001454335.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate YP_001454336.1 Psort location: cytoplasmic, score: 23 YP_001454337.1 KEGG: bps:BPSS1635 0.00051 probable class III aminotransferase K00836; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001454338.1 COG: COG3921 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001454339.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001454340.1 COG: NOG09786 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001454341.1 COG: NOG11448 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 23 YP_001454342.1 KEGG: abo:ABO_0207 0.0095 pyrE; orotate phosphoribosyltransferase K00762; COG: NOG06003 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454343.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope YP_001454344.1 Psort location: mitochondrial, score: 23 YP_001454345.1 this protein has no known enzymatic function YP_001454346.1 COG: NOG06782 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454347.1 KEGG: eci:UTI89_C0334 7.5e-56 hypothetical protein; COG: COG3468 Type V secretory pathway, adhesin AidA; Psort location: extracellular, including cell wall, score: 9 YP_001454348.1 Psort location: cytoplasmic, score: 23 YP_001454349.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001454350.1 KEGG: gsu:GSU3116 0.00031 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative K00655; COG: COG3176 Putative hemolysin; Psort location: cytoplasmic, score: 23 YP_001454351.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers YP_001454352.1 KEGG: rha:RHA1_ro08170 4.1e-23 ABC transporter, permease component; COG: COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001454353.1 Part of the ABC transporter complex tauABC involved in taurine import YP_001454354.1 with TauB and TauC is responsible for taurine uptake. YP_001454355.1 Psort location: nuclear, score: 23 YP_001454356.1 Psort location: mitochondrial, score: 23 YP_001454357.1 Psort location: cytoplasmic, score: 23 YP_001454358.1 KEGG: bur:Bcep18194_B2520 4.3e-28 two component transcriptional regulator, LuxR family; COG: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001454359.1 KEGG: ece:Z0462 4.2e-236 putative sensor kinase; hexosephosphate transport K07675; COG: COG3851 Signal transduction histidine kinase, glucose-6-phosphate specific; Psort location: plasma membrane, score: 23 YP_001454360.1 COG: COG2271 Sugar phosphate permease; Psort location: endoplasmic reticulum, score: 9 YP_001454361.1 COG: COG1840 ABC-type Fe3+ transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001454362.1 KEGG: cdi:DIP0495 3.8e-12 putative molybdenum ABC transport system (integral membrane and ATP-binding proteins) K02017:K02018; COG: COG1178 ABC-type Fe3+ transport system, permease component; Psort location: plasma membrane, score: 23 YP_001454363.1 Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import YP_001454364.1 converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines YP_001454365.1 Psort location: mitochondrial, score: 23 YP_001454366.1 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer YP_001454367.1 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon YP_001454368.1 Psort location: mitochondrial, score: 23 YP_001454369.1 catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent YP_001454370.1 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C YP_001454371.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity YP_001454372.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate YP_001454373.1 KEGG: reh:H16_A1904 2.7e-83 prpR; propionate catabolism activator K01529; COG: COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001454374.1 COG: NOG14127 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454375.1 COG: COG1280 Putative threonine efflux protein; Psort location: plasma membrane, score: 23 YP_001454376.1 KEGG: shn:Shewana3_1692 2.8e-09 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001454377.1 COG: COG1538 Outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001454378.1 KEGG: eci:UTI89_C2351 8.4e-112 yegO; hypothetical protein YegO K07789; COG: COG0841 Cation/multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001454379.1 COG: COG0845 Membrane-fusion protein; Psort location: extracellular, including cell wall, score: 9 YP_001454380.1 COG: COG1309 Transcriptional regulator; Psort location: nuclear, score: 23 YP_001454381.1 Psort location: cytoplasmic, score: 23 YP_001454382.1 Psort location: mitochondrial, score: 23 YP_001454383.1 KEGG: bpm:BURPS1710b_3090 1.1e-09 glk; glucokinase/transcriptional regulator, RpiR family, fusion K00845; COG: COG1737 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001454384.1 COG: COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001454385.1 KEGG: mca:MCA0514 0.0024 NADH ubiquinone/plastoquinone complex subunit, putative K00329; COG: COG0609 ABC-type Fe3+-siderophore transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001454386.1 KEGG: rpa:RPA3982 0.00089 glycosyl transferase, family 4 K02851; COG: COG0609 ABC-type Fe3+-siderophore transport system, permease component; Psort location: plasma membrane, score: 23 YP_001454387.1 KEGG: ecc:c3774 1.3e-108 fepC; ferric enterobactin transport ATP-binding protein fepC K02013; COG: COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001454388.1 Psort location: nuclear, score: 23 YP_001454389.1 Psort location: nuclear, score: 23 YP_001454390.1 COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: extracellular, including cell wall, score: 9 YP_001454391.1 tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan YP_001454392.1 tryptophan transporter of high affinity YP_001454393.1 Psort location: nuclear, score: 23 YP_001454394.1 COG: NOG08675 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454395.1 KEGG: sfl:SF1683 1.0e-33 ydhO; putative lipoprotein K01183; COG: COG0791 Cell wall-associated hydrolases (invasion-associated proteins); Psort location: nuclear, score: 23 YP_001454396.1 COG: COG1360 Flagellar motor protein; Psort location: mitochondrial, score: 23 YP_001454397.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_001454398.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes YP_001454399.1 COG: NOG23225 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454400.1 Psort location: extracellular, including cell wall, score: 9 YP_001454401.1 KEGG: mmu:75560 0.00035 Ep400; E1A binding protein p400 K01529; COG: COG3144 Flagellar hook-length control protein; Psort location: nuclear, score: 23 YP_001454402.1 Psort location: mitochondrial, score: 23 YP_001454403.1 Psort location: vesicles of secretory system, score: 9 YP_001454404.1 COG: COG1516 Flagellin-specific chaperone FliS; Psort location: cytoplasmic, score: 23 YP_001454405.1 KEGG: cal:orf19.4072 4.7e-05 HYR10; similar to cell surface flocculin K01186; COG: COG1345 Flagellar capping protein; Psort location: nuclear, score: 23 YP_001454406.1 KEGG: pfa:PFB0150c 0.0046 protein kinase, putative K00870; COG: COG1344 Flagellin and related hook-associated proteins; Psort location: cytoplasmic, score: 23 YP_001454407.1 Psort location: cytoplasmic, score: 23 YP_001454408.1 Psort location: extracellular, including cell wall, score: 9 YP_001454409.1 COG: COG1344 Flagellin and related hook-associated proteins; Psort location: nuclear, score: 23 YP_001454410.1 Psort location: cytoplasmic, score: 23 YP_001454411.1 KEGG: eci:UTI89_C2354 0.0014 baeR; transcriptional response regulatory protein BaeR K07664; COG: COG3710 DNA-binding winged-HTH domains; Psort location: nuclear, score: 23 YP_001454412.1 COG: NOG37669 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454413.1 COG: NOG18853 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001454414.1 COG: COG1344 Flagellin and related hook-associated proteins; Psort location: nuclear, score: 23 YP_001454415.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_001454416.1 FlgJ; flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; like the lateral flagella FlgJ in Vibrio parahaemolyticus this protein does not contains a C-terminal muramidase domain YP_001454417.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_001454418.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; the Yersinia have 2 copies of flgH YP_001454419.1 makes up the distal portion of the flagellar basal body rod YP_001454420.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod YP_001454421.1 KEGG: eci:UTI89_C4143 0.00095 putative autotransport adhesin K01423; COG: COG1749 Flagellar hook protein FlgE; Psort location: nuclear, score: 23 YP_001454422.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; Vibrio parahaemolyticus protein in this cluster is associated with lateral flagella production YP_001454423.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the lateral flagella YP_001454424.1 COG: COG1815 Flagellar basal body protein; Psort location: mitochondrial, score: 23 YP_001454425.1 required for the assembly of the flagellar basal body P-ring; the Vibrio parahaemolyticus protein involved with the synthesis of the lateral flagella YP_001454426.1 Psort location: nuclear, score: 23 YP_001454427.1 Psort location: nuclear, score: 23 YP_001454428.1 Psort location: extracellular, including cell wall, score: 9 YP_001454429.1 COG: NOG23221 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001454430.1 KEGG: gox:GOX1390 0.0016 methyltransferase K03183; COG: COG0457 FOG: TPR repeat; Psort location: mitochondrial, score: 23 YP_001454431.1 KEGG: sat:SYN_01107 9.3e-26 glycosyltransferase K00754; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001454432.1 KEGG: pmu:PM1844 5.3e-09 rfaF; ADP-heptose--LPS heptosyltransferase II K02843; COG: COG0859 ADP-heptose:LPS heptosyltransferase; Psort location: cytoplasmic, score: 23 YP_001454433.1 KEGG: sec:SC1961 4.0e-11 fliB; N-methylation of lysine residues in flagellin K00599; COG: NOG18602 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454434.1 KEGG: eci:UTI89_C2333 6.1e-10 wcaA; putative colanic acid biosynthesis glycosyltransferase WcaA; COG: COG3306 Glycosyltransferase involved in LPS biosynthesis; Psort location: cytoplasmic, score: 23 YP_001454435.1 KEGG: tbr:Tb10.70.7860 0.0026 protein kinase K08857; COG: NOG37799 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001454436.1 KEGG: ypa:YPA_3072 3.1e-176 putative flagellum-specific ATP synthase K02412; COG: COG1157 Flagellar biosynthesis/type III secretory pathway ATPase; Psort location: cytoplasmic, score: 23 YP_001454437.1 binds to and inhibits the function of flagella specific ATPase FliI YP_001454438.1 One of three proteins involved in switching the direction of the flagellar rotation YP_001454439.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; the Vibrio parahaemolyticus protein is associated with the lateral flagella YP_001454440.1 KEGG: sye:Syncc9902_2308 0.00027 argininosuccinate synthase K01940; COG: COG1677 Flagellar hook-basal body protein; Psort location: mitochondrial, score: 23 YP_001454441.1 KEGG: eci:UTI89_C2502 3.3e-69 atoC; acetoacetate metabolism regulatory protein AtoC K07714; COG: COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains; Psort location: cytoplasmic, score: 23 YP_001454442.1 COG: NOG26448 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454443.1 COG: COG1886 Flagellar motor switch/type III secretory pathway protein; Psort location: cytoplasmic, score: 23 YP_001454444.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_001454445.1 COG: COG1987 Flagellar biosynthesis pathway, component FliQ; Psort location: endoplasmic reticulum, score: 9 YP_001454446.1 COG: COG1684 Flagellar biosynthesis pathway, component FliR; Psort location: plasma membrane, score: 23 YP_001454447.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_001454448.1 membrane protein involved in the flagellar export apparatus YP_001454449.1 COG: COG4461 Uncharacterized protein conserved in bacteria, putative lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001454450.1 KEGG: eci:UTI89_C1702 7.0e-26 hypothetical protein; COG: COG2200 FOG: EAL domain; Psort location: endoplasmic reticulum, score: 9 YP_001454451.1 COG: NOG12165 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454452.1 Psort location: endoplasmic reticulum, score: 9 YP_001454453.1 COG: NOG09853 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454454.1 Psort location: nuclear, score: 23 YP_001454455.1 KEGG: azo:azo2292 7.2e-05 ada; methylated-DNA--[protein]-cysteine S-methyltransferase K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001454456.1 COG: NOG14917 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454457.1 Psort location: cytoplasmic, score: 23 YP_001454458.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: nuclear, score: 23 YP_001454459.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001454460.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: cytoplasmic, score: 23 YP_001454461.1 KEGG: chu:CHU_0938 0.0054 CHU large protein; uncharacterized K01238; COG: COG3188 P pilus assembly protein, porin PapC; Psort location: nuclear, score: 23 YP_001454462.1 COG: NOG07909 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454463.1 KEGG: ecc:c0514 0.0014 yajB; hypothetical protein YajB K08682; Psort location: golgi, score: 9 YP_001454464.1 COG: NOG24886 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454465.1 COG: COG4943 Predicted signal transduction protein containing sensor and EAL domains; Psort location: cytoplasmic, score: 23 YP_001454466.1 Psort location: cytoplasmic, score: 23 YP_001454467.1 KEGG: lwe:lwe1439 7.0e-44 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein); Psort location: extracellular, including cell wall, score: 9 YP_001454468.1 KEGG: pol:Bpro_1157 2.6e-94 histidine ammonia-lyase K01745; COG: COG2986 Histidine ammonia-lyase; Psort location: cytoplasmic, score: 23 YP_001454469.1 KEGG: lwe:lwe1439 1.2e-32 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1174 ABC-type proline/glycine betaine transport systems, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001454470.1 KEGG: lwe:lwe1439 2.1e-37 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1174 ABC-type proline/glycine betaine transport systems, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001454471.1 KEGG: sma:SAV7409 1.9e-80 putative ABC transporter ATP-binding protein K02000; COG: COG1125 ABC-type proline/glycine betaine transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001454472.1 KEGG: reh:H16_A1394 1.0e-145 arcB; orniTHIne cyclodeaminase K01750; COG: COG2423 Predicted orniTHIne cyclodeaminase, mu-crystallin homolog; Psort location: cytoplasmic, score: 23 YP_001454473.1 COG: COG3221 ABC-type phosphate/phosphonate transport system, periplasmic component; Psort location: cytoplasmic, score: 23 YP_001454474.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001454475.1 KEGG: rha:RHA1_ro10323 9.5e-26 ABC branched chain amino acid transporter ATP-binding subunit; COG: COG0559 Branched-chain amino acid ABC-type transport system, permease components; Psort location: plasma membrane, score: 23 YP_001454476.1 KEGG: reh:H16_A3653 2.0e-28 ABC-type transporter, ATPase and permease components; COG: COG4177 ABC-type branched-chain amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001454477.1 KEGG: reh:H16_A3027 4.6e-79 livG2; ABC-type transporter, ATPase component: HAAT family; COG: COG0411 ABC-type branched-chain amino acid transport systems, ATPase component; Psort location: cytoskeletal, score: 9 YP_001454478.1 KEGG: bur:Bcep18194_A5826 1.3e-67 ABC branched-chain amino acid family transporter, ATPase subunit K01996; COG: COG0410 ABC-type branched-chain amino acid transport systems, ATPase component; Psort location: cytoplasmic, score: 23 YP_001454479.1 KEGG: ava:Ava_2791 3.1e-05 serine/threonine protein kinase K00903; COG: COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001454480.1 COG: NOG11865 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454481.1 KEGG: bxe:Bxe_A1427 1.7e-120 amidase, hydantoinase/carbamoylase K01431; COG: COG0624 AcetylorniTHIne deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases; Psort location: cytoplasmic, score: 23 YP_001454482.1 COG: NOG05997 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001454483.1 catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate YP_001454484.1 KEGG: psp:PSPPH_2083 0.00028 sensor histidine kinase/response regulator; Psort location: cytoplasmic, score: 23 YP_001454485.1 KEGG: efa:EF1922 2.4e-08 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001454486.1 KEGG: ecp:ECP_2753 1.4e-189 sucrose-6-phosphate hydrolase K01193; COG: COG1621 Beta-fructosidases (levanase/invertase); Psort location: vesicles of secretory system, score: 9 YP_001454487.1 KEGG: ecp:ECP_2752 1.0e-223 PTS system, sucrose-specific IIBC component K02809:K02810; COG: COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific; Psort location: plasma membrane, score: 23 YP_001454488.1 COG: COG4580 Maltoporin (phage lambda and maltose receptor); Psort location: extracellular, including cell wall, score: 9 YP_001454489.1 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least YP_001454490.1 KEGG: eci:UTI89_C1370 3.2e-18 umuC; UmuC protein K03502; COG: COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; Psort location: cytoplasmic, score: 23 YP_001454491.1 Psort location: cytoplasmic, score: 23 YP_001454492.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001454493.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_001454494.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_001454495.1 Psort location: cytoplasmic, score: 23 YP_001454496.1 COG: COG3203 Outer membrane protein (porin); Psort location: extracellular, including cell wall, score: 9 YP_001454497.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS YP_001454498.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation YP_001454499.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively YP_001454500.1 KEGG: ece:Z0298 1.7e-225 pepD; aminoacyl-histidine dipeptidase (peptidase D) K01270; COG: COG2195 Di- and tripeptidases; Psort location: cytoplasmic, score: 23 YP_001454501.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_001454502.1 COG: COG3034 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001454503.1 KEGG: reh:H16_A0476 4.4e-67 predicted glutamine amidotransferase class II; COG: COG0121 Predicted glutamine amidotransferase; Psort location: cytoplasmic, score: 23 YP_001454504.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate YP_001454506.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA YP_001454507.1 KEGG: eco:b0219 1.3e-120 yafV; predicted C-N hydrolase family amidase, NAD(P)-binding; COG: COG0388 Predicted amidohydrolase; Psort location: cytoplasmic, score: 23 YP_001454508.1 3'-5' exonuclease of DNA polymerase III YP_001454509.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_001454510.1 KEGG: vfi:VF1937 7.6e-47 methyltransferase K00599; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001454511.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione YP_001454512.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall YP_001454513.1 KEGG: eci:UTI89_C0229 3.6e-111 yafE; conserved hypothetical protein YafE K00599; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001454514.1 COG: COG3021 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001454515.1 KEGG: shn:Shewana3_3435 1.5e-09 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001454516.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid YP_001454518.1 Psort location: mitochondrial, score: 23 YP_001454519.1 involved in de novo purine biosynthesis YP_001454520.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_001454521.1 COG: NOG06219 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454522.1 histone-like DNA-binding protein YP_001454523.1 COG: COG3068 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001454524.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures YP_001454525.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_001454526.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates YP_001454527.1 binds specifically to the major sigma factor sigma 70; active in stationary phase YP_001454528.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_001454529.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate YP_001454530.1 KEGG: eci:UTI89_C3827 1.2e-114 THIF; adenylyltransferase ThiF K03148; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and THIamine biosynthesis family 2; Psort location: cytoplasmic, score: 23 YP_001454531.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate YP_001454532.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_001454533.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center YP_001454534.1 Psort location: mitochondrial, score: 23 YP_001454535.1 KEGG: plu:plu2754 1.0e-28 celA; PTS system, cellobiose-specific IIB component K02760; COG: COG1440 Phosphotransferase system cellobiose-specific component IIB; Psort location: cytoplasmic, score: 23 YP_001454536.1 KEGG: plu:plu2756 3.7e-31 celC; PTS system, cellobiose-specific IIA component (EIIA-CEL) (cellobiose-permease IIA component) (phosphotransferase enzyme II, A component) (EIII-CEL) K02759; COG: COG1447 Phosphotransferase system cellobiose-specific component IIA; Psort location: cytoplasmic, score: 23 YP_001454537.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001454538.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001454539.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001454540.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001454541.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001454542.1 Psort location: cytoplasmic, score: 23 YP_001454543.1 binds directly to 23S ribosomal RNA YP_001454544.1 Modulates Rho-dependent transcription termination YP_001454545.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_001454546.1 Psort location: cytoplasmic, score: 23 YP_001454547.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001454548.1 COG: NOG15364 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454549.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_001454550.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon YP_001454551.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_001454552.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_001454553.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space YP_001454554.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs YP_001454555.1 Psort location: mitochondrial, score: 23 YP_001454556.1 COG: NOG10261 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001454557.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis YP_001454558.1 Psort location: nuclear, score: 23 YP_001454559.1 catalyzes the conversion of NADPH to NADH YP_001454560.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA YP_001454561.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_001454562.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_001454563.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_001454564.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis YP_001454565.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_001454566.1 KEGG: pha:PSHAa2772 3.1e-21 eptA; lipid A phosphoethanolamine transferase, associated with polymyxin resistance K03760; COG: COG2194 Predicted membrane-associated, metal-dependent hydrolase; Psort location: endoplasmic reticulum, score: 9 YP_001454567.1 KEGG: bli:BL05281 2.5e-11 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001454568.1 FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog YP_001454569.1 KEGG: stm:STM4115 2.8e-88 pflC; putative pyruvate formate lyase activating enzyme 2 K04069; COG: COG1180 Pyruvate-formate lyase-activating enzyme; Psort location: cytoplasmic, score: 23 YP_001454570.1 involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein YP_001454571.1 FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS YP_001454572.1 FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site YP_001454573.1 Psort location: cytoskeletal, score: 9 YP_001454574.1 KEGG: sec:SC4002 0. ptsA; general PTS family, enzyme I K02766:K02768; COG: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); Psort location: cytoplasmic, score: 23 YP_001454575.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies YP_001454576.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone YP_001454577.1 KEGG: stm:STM4106 0. katG; catalase; hydroperoxidase HPI(I) K03782; COG: COG0376 Catalase (peroxidase I); Psort location: cytoplasmic, score: 23 YP_001454578.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor YP_001454579.1 KEGG: shn:Shewana3_3435 2.9e-16 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001454580.1 KEGG: azo:azo3958 9.0e-44 pcaC; 4-carboxymuconolactone decarboxylase K01607; COG: COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit; Psort location: cytoplasmic, score: 23 YP_001454581.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_001454582.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine YP_001454583.1 Psort location: cytoplasmic, score: 23 YP_001454584.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis YP_001454585.1 Psort location: cytoplasmic, score: 23 YP_001454586.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_001454587.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins YP_001454588.1 KEGG: rno:309804 3.2e-12 Cdc2l6_predicted; cell division cycle 2-like 6 (CDK8-like) (predicted) K02208; COG: COG3087 Cell division protein; Psort location: nuclear, score: 23 YP_001454589.2 heat shock protein involved in degradation of misfolded proteins YP_001454590.1 heat shock protein involved in degradation of misfolded proteins YP_001454591.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_001454592.1 COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001454593.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_001454594.1 Psort location: nuclear, score: 23 YP_001454595.1 Psort location: cytoplasmic, score: 23 YP_001454596.1 KEGG: rno:85240 0.0017 Plcb2; phospholipase C, beta 2 K05858; COG: COG3074 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001454597.1 Psort location: nuclear, score: 23 YP_001454598.1 KEGG: fal:FRAAL3366 0.0019 putative arsenate reductase (partial match); COG: COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family); Psort location: endoplasmic reticulum, score: 9 YP_001454599.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_001454600.1 COG: COG5499 Predicted transcription regulator containing HTH domain; Psort location: cytoplasmic, score: 23 YP_001454601.1 COG: COG4680 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001454602.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_001454603.1 KEGG: ecs:ECs4849 2.6e-124 ferredoxin-NADP reductase K00528; COG: COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1; Psort location: cytoplasmic, score: 23 YP_001454604.1 COG: COG3152 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001454605.1 COG: NOG06218 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454606.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_001454607.1 COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001454608.1 KEGG: sec:SC3955 1.9e-112 ushB; CDP-diacylglycerol phosphotidylhydrolase K01521; COG: COG2134 CDP-diacylglycerol pyrophosphatase; Psort location: extracellular, including cell wall, score: 9 YP_001454609.1 Psort location: cytoplasmic, score: 23 YP_001454610.1 COG: COG1613 ABC-type sulfate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001454611.1 Psort location: mitochondrial, score: 23 YP_001454612.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_001454613.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers YP_001454614.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates YP_001454615.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system YP_001454616.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors YP_001454617.1 COG: COG2258 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001454618.1 KEGG: rpc:RPC_4382 6.9e-37 dihydrodipicolinate synthetase K01714; COG: COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Psort location: cytoplasmic, score: 23 YP_001454619.1 transports degraded pectin products into the bacterial cell YP_001454620.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals YP_001454621.1 transports L-rhamnose and L-lyxose into the cell YP_001454622.1 KEGG: bcz:BCZK3497 1.9e-09 adaA; transcriptional regulator, AraC family K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: nuclear, score: 23 YP_001454623.1 Psort location: cytoplasmic, score: 23 YP_001454624.1 Psort location: mitochondrial, score: 23 YP_001454625.1 Psort location: nuclear, score: 23 YP_001454626.1 activates the expression of the rhaBAD operon and rhaT gene YP_001454627.1 Psort location: cytoplasmic, score: 23 YP_001454628.1 catalyzes the ATP-dependent phosphorylation of rhamnulose YP_001454629.1 catalyzes the formation of L-rhamnulose from L-rhamnose YP_001454630.1 KEGG: spt:SPA3888 3.2e-142 rhaD; rhamnulose-1-phosphate aldolase K01629; COG: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; Psort location: cytoplasmic, score: 23 YP_001454631.1 Psort location: nuclear, score: 23 YP_001454632.1 KEGG: stm:STM4044 2.5e-190 putative alcohol dehydrogenase K00001; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: cytoplasmic, score: 23 YP_001454633.1 KEGG: msm:MSMEG_0587 8.4e-09 rhaU; L-rhamnose 1-epimerase; COG: COG3254 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001454634.1 KEGG: psp:PSPPH_2917 9.5e-09 DNA-binding protein K00517; COG: COG1396 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001454635.1 COG: COG1296 Predicted branched-chain amino acid permease (azaleucine resistance); Psort location: endoplasmic reticulum, score: 9 YP_001454636.1 COG: NOG19750 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001454637.1 COG: NOG13870 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454638.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_001454639.1 Psort location: extracellular, including cell wall, score: 9 YP_001454640.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: mitochondrial, score: 23 YP_001454641.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001454642.1 COG: NOG11500 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454643.1 KEGG: ecs:ECs4820 6.0e-102 formate dehydrogenase-O major subunit K00123; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: extracellular, including cell wall, score: 9 YP_001454644.1 KEGG: sty:STY3839 0. fdoG; formate dehydrogenase-O, major subunit K00123; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001454645.1 KEGG: stm:STM4036 6.1e-164 fdoH; formate dehydrogenase-O, Fe-S subunit K00124; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: cytoplasmic, score: 23 YP_001454646.1 cytochrome b556(FDO) component; heme containing YP_001454647.1 required for the formation of active formate dehydrogenase YP_001454648.1 COG: NOG18543 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454649.1 COG: NOG13906 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454650.1 Psort location: nuclear, score: 23 YP_001454651.1 KEGG: eci:UTI89_C4472 9.4e-168 yiiD; putative acetyltransferase K00633; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001454652.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_001454653.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease YP_001454654.1 KEGG: lil:LA1476 2.6e-09 putative haloacid dehalogenase-like hydrolase K01560; COG: COG1011 Predicted hydrolase (HAD superfamily); Psort location: cytoplasmic, score: 23 YP_001454655.1 KEGG: eci:UTI89_C2514 1.2e-55 yfaL; hypothetical protein YfaL precursor K07279; COG: COG3468 Type V secretory pathway, adhesin AidA; Psort location: mitochondrial, score: 23 YP_001454656.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001454657.1 KEGG: eci:UTI89_C4462 3.3e-101 yihV; hypothetical sugar kinase YihV K00846; COG: COG0524 Sugar kinases, ribokinase family; Psort location: extracellular, including cell wall, score: 9 YP_001454658.1 KEGG: spt:SPA3864 6.4e-137 yihU; putative oxidoreductase K08318; COG: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001454659.1 KEGG: eco:b3881 3.0e-139 yihT; predicted aldolase; COG: COG3684 Tagatose-1,6-bisphosphate aldolase; Psort location: cytoplasmic, score: 23 YP_001454660.1 KEGG: eco:b3880 2.7e-216 yihS; predicted glucosamine isomerase; COG: COG2942 N-acyl-D-glucosamine 2-epimerase; Psort location: cytoplasmic, score: 23 YP_001454661.1 KEGG: lil:LA2944 6.2e-100 Alpha-glucosidase II K01187; COG: COG1501 Alpha-glucosidases, family 31 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001454662.1 KEGG: lil:LA2944 6.3e-20 Alpha-glucosidase II K01187; COG: COG1501 Alpha-glucosidases, family 31 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001454663.1 KEGG: eci:UTI89_C4210 4.7e-47 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: endoplasmic reticulum, score: 9 YP_001454664.1 KEGG: eci:UTI89_C4210 5.5e-44 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001454665.1 porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown YP_001454666.1 KEGG: eci:UTI89_C4460 0. typA, bipA, yihK, yjhK; putative GTP-binding factor K06207; COG: COG1217 Predicted membrane GTPase involved in stress response; Psort location: cytoplasmic, score: 23 YP_001454667.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme YP_001454668.1 Psort location: endoplasmic reticulum, score: 9 YP_001454669.1 Psort location: nuclear, score: 23 YP_001454670.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation YP_001454671.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54 YP_001454672.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001454673.1 KEGG: cfa:489591 0.0045 LOC489591; similar to cell division cycle 2-like 1 (PITSLRE proteins) isoform 1 K08818; COG: COG3078 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001454674.1 Psort location: cytoplasmic, score: 23 YP_001454675.1 KEGG: reh:H16_A3452 3.3e-37 predicted GTPase K01529; COG: COG0218 Predicted GTPase; Psort location: cytoplasmic, score: 23 YP_001454676.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_001454677.1 Psort location: nuclear, score: 23 YP_001454678.1 KEGG: eci:UTI89_C4450 5.1e-144 yihG; hypothetical protein YihG K00655; COG: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; Psort location: endoplasmic reticulum, score: 9 YP_001454679.1 KEGG: bci:BCI_0257 1.3e-51 dsbA; THIol:disulfide interchange protein DsbA K01829; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: extracellular, including cell wall, score: 9 YP_001454680.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages YP_001454681.1 COG: COG3084 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001454682.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_001454683.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway YP_001454684.1 Psort location: nuclear, score: 23 YP_001454686.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate YP_001454687.1 part of the metNIQ transport system for methionine YP_001454688.1 part of the MetNIQ methionine uptake system YP_001454689.1 COG: COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen; Psort location: extracellular, including cell wall, score: 9 YP_001454690.1 COG: NOG09836 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001454691.1 Psort location: cytoplasmic, score: 23 YP_001454692.1 KEGG: eci:UTI89_C0211 1.0e-65 yaeB; hypothetical protein YaeB; COG: COG1720 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001454693.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001454694.1 COG: COG3015 Uncharacterized lipoprotein NlpE involved in copper resistance; Psort location: endoplasmic reticulum, score: 9 YP_001454695.1 KEGG: reh:H16_A3611 7.4e-33 pth2; peptidyl-tRNA hydrolase; COG: COG1186 Protein chain release factor B; Psort location: nuclear, score: 23 YP_001454696.1 KEGG: bpm:BURPS1710b_0319 5.9e-40 YaeQ protein K00356; COG: COG4681 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001454697.1 COG: NOG13866 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454698.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination YP_001454699.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase YP_001454700.1 KEGG: stt:t0237 2.9e-61 hypothetical protein K01759; COG: COG0346 LactoylglutaTHIone lyase and related lyases; Psort location: cytoplasmic, score: 23 YP_001454701.1 KEGG: eco:b0186 0. ldcC; lysine decarboxylase 2, constitutive K01582; COG: COG1982 Arginine/lysine/orniTHIne decarboxylases; Psort location: cytoplasmic, score: 23 YP_001454702.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_001454703.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_001454704.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001454705.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_001454706.1 KEGG: ssn:SSO_0193 1.4e-77 lpxA; UDP-N-acetylglucosamine acetyltransferase; lipid A biosynthesis K00677; COG: COG1043 Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase; Psort location: cytoplasmic, score: 23 YP_001454707.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_001454708.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_001454709.1 COG: COG2825 Outer membrane protein; Psort location: nuclear, score: 23 YP_001454710.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins YP_001454711.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response YP_001454712.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate YP_001454713.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_001454714.1 Psort location: cytoplasmic, score: 23 YP_001454715.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_001454716.1 KEGG: fth:FTH_0222 1.0e-44 prfH; protein-synthesizing GTPase; COG: COG0233 Ribosome recycling factor; Psort location: nuclear, score: 23 YP_001454717.1 Catalyzes the phosphorylation of UMP to UDP YP_001454718.1 Psort location: cytoplasmic, score: 23 YP_001454719.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001454720.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001454721.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_001454722.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_001454723.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_001454724.1 COG: NOG09673 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001454725.1 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization YP_001454726.1 protease Do; required at high temperature; degrades damaged proteins YP_001454727.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate YP_001454728.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_001454729.1 solute binding component of the vitamin B12 transport system BtuCDF YP_001454730.1 COG: COG2860 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001454731.1 COG: COG0316 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001454732.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation YP_001454733.1 Psort location: cytoplasmic, score: 23 YP_001454734.1 KEGG: sbo:SBO_0143 1.2e-183 hemL; glutamate-1-semialdehyde aminotransferase K01845; COG: COG0001 Glutamate-1-semialdehyde aminotransferase; Psort location: cytoplasmic, score: 23 YP_001454735.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome YP_001454736.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores YP_001454737.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter YP_001454738.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein YP_001454739.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell YP_001454740.1 Psort location: cytoplasmic, score: 23 YP_001454741.1 similar in sequence to the ATP-dependent RNA helicase HrpA YP_001454742.1 KEGG: stm:STM0188 2.2e-81 ligT; 2'-5' RNA ligase K01975; COG: COG1514 2-5 RNA ligase; Psort location: extracellular, including cell wall, score: 9 YP_001454743.1 Regulatory factor involved in maltose metabolism YP_001454744.1 COG: COG1734 DnaK suppressor protein; Psort location: nuclear, score: 23 YP_001454745.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu YP_001454746.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's YP_001454747.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP YP_001454748.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_001454749.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_001454750.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_001454751.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001454752.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: cytoplasmic, score: 23 YP_001454753.1 similar to the fimbrial usher protein PapC YP_001454754.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: cytoplasmic, score: 23 YP_001454755.1 KEGG: chu:CHU_0837 0.0017 CHU large protein; uncharacterized K01238; COG: NOG14108 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454756.1 COG: NOG18510 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454757.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001454758.1 KEGG: sty:STY0196 1.5e-64 yadI; putative PTS system IIA component K02821; COG: COG2893 Phosphotransferase system, mannose/fructose-specific component IIA; Psort location: cytoplasmic, score: 23 YP_001454759.1 COG: COG0842 ABC-type multidrug transport system, permease component; Psort location: plasma membrane, score: 23 YP_001454760.1 KEGG: pen:PSEEN1596 9.8e-102 ABC transporter, ATP-binding protein; COG: COG1131 ABC-type multidrug transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001454761.1 catalyzes the interconversion of bicarbonate and carbon dioxide YP_001454762.1 KEGG: sfx:S0124 3.9e-91 hpt; hypoxanTHIne phosphoribosyltransferase K00760; COG: COG0634 HypoxanTHIne-guanine phosphoribosyltransferase; Psort location: cytoplasmic, score: 23 YP_001454763.1 KEGG: stm:STM0169 0. gcd; glucose dehydrogenase K00117; COG: COG4993 Glucose dehydrogenase; Psort location: endoplasmic reticulum, score: 9 YP_001454764.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification YP_001454765.1 COG: NOG09835 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454766.1 Psort location: cytoplasmic, score: 23 YP_001454767.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_001454768.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine YP_001454769.1 COG: COG3112 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001454770.1 Psort location: mitochondrial, score: 23 YP_001454771.1 Psort location: nuclear, score: 23 YP_001454772.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_001454773.1 Psort location: cytoplasmic, score: 23 YP_001454774.1 KEGG: cdi:DIP0942 0.0019 xseA; exodeoxyribonuclease VII large subunit K03601; COG: NOG06276 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001454775.1 COG: NOG09806 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454776.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001454777.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains YP_001454778.1 Psort location: cytoplasmic, score: 23 YP_001454779.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_001454780.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex YP_001454781.1 Psort location: cytoplasmic, score: 23 YP_001454782.1 KEGG: eci:UTI89_C0120 2.5e-231 aroP; aromatic amino acid transport protein AroP K03293; COG: COG1113 Gamma-aminobutyrate permease and related permeases; Psort location: plasma membrane, score: 23 YP_001454783.1 KEGG: eci:UTI89_C4210 1.3e-115 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001454784.1 KEGG: sde:Sde_0777 2.4e-98 ribosomal protein L11 methyltransferase K01209; COG: COG3940 Predicted beta-xylosidase; Psort location: cytoplasmic, score: 23 YP_001454785.1 involved in regulation of beta-lactamase; putative signaling protein YP_001454786.1 KEGG: eci:UTI89_C0118 1.9e-89 ampD; AmpD protein K03806; COG: COG3023 Negative regulator of beta-lactamase expression; Psort location: cytoplasmic, score: 23 YP_001454787.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide YP_001454788.1 COG: COG4969 Tfp pilus assembly protein, major pilin PilA; Psort location: mitochondrial, score: 23 YP_001454789.1 KEGG: pen:PSEEN2333 1.7e-81 xcpR-2; type II secretion pathway protein E K01509; COG: COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB; Psort location: cytoplasmic, score: 23 YP_001454790.1 COG: COG1459 Type II secretory pathway, component PulF; Psort location: endoplasmic reticulum, score: 23 YP_001454791.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate YP_001454792.1 Psort location: mitochondrial, score: 23 YP_001454793.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_001454794.1 COG: COG4582 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001454795.1 KEGG: gbe:GbCGDNIH1_1027 6.1e-06 ribonuclease G; COG: COG3024 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001454796.1 KEGG: spt:SPA0139 5.5e-60 mutT; 7,8-dihydro-8-oxoguanine-triphosphatase K03574; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001454797.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_001454798.1 secM translational pause allows for the initiation of secA translation YP_001454799.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_001454800.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_001454801.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane YP_001454802.1 involved in septum formation YP_001454803.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001454804.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001454805.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001454806.1 integral membrane protein involved in stabilizing FstZ ring during cell division YP_001454807.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_001454808.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001454809.1 KEGG: ssn:SSO_0094 1.0e-216 murF; D-alanine:D-alanine-adding enzyme K01929; COG: COG0770 UDP-N-acetylmuramyl pentapeptide synthase; Psort location: cytoplasmic, score: 23 YP_001454810.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_001454811.1 KEGG: sty:STY0142 1.1e-301 ftsI; penicillin-binding protein 3 precursor K03587; COG: COG0768 Cell division protein FtsI/penicillin-binding protein 2; Psort location: endoplasmic reticulum, score: 23 YP_001454812.1 membrane bound cell division protein at septum containing leucine zipper motif YP_001454813.1 KEGG: stm:STM0120 1.6e-158 yabC; putative S-adenosyl meTHIonine adenyltransferase K03438; COG: COG0275 Predicted S-adenosylmeTHIonine-dependent methyltransferase involved in cell envelope biogenesis; Psort location: cytoplasmic, score: 23 YP_001454814.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_001454815.1 Psort location: cytoplasmic, score: 23 YP_001454816.1 Psort location: vesicles of secretory system, score: 9 YP_001454817.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism YP_001454818.1 Psort location: cytoplasmic, score: 23 YP_001454819.1 Psort location: nuclear, score: 23 YP_001454820.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_001454821.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive YP_001454822.1 activator for leuABCD operon; member of LysR family of transcriptional activators YP_001454823.1 Psort location: endoplasmic reticulum, score: 9 YP_001454824.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_001454825.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_001454826.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_001454827.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_001454828.1 Psort location: nuclear, score: 23 YP_001454829.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001454830.1 Psort location: mitochondrial, score: 23 YP_001454831.1 Psort location: nuclear, score: 23 YP_001454832.1 activates sgrS under glucose-phosphate stress conditions YP_001454833.1 part of the thiamine and TPP transport system tbpA-thiPQ YP_001454834.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine YP_001454835.1 with TbpA and ThiP is part of the thiamine and TPP transport system YP_001454836.1 KEGG: lsl:LSL_1322 7.6e-05 alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: plasma membrane, score: 23 YP_001454837.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose YP_001454838.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate YP_001454839.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism YP_001454840.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_001454841.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C YP_001454842.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA YP_001454843.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs YP_001454844.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system YP_001454845.1 determines N-hexane tolerance and is involved in outer membrane permeability YP_001454846.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB YP_001454847.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_001454848.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001454849.1 protein associated with Co2+ and Mg2+ efflux YP_001454850.1 Psort location: cytoplasmic, score: 23 YP_001454851.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_001454852.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate YP_001454853.1 transport system that facilitates potassium-efflux YP_001454854.1 Required for full activity of KefC, a potassium-proton antiporter YP_001454855.1 COG: NOG17119 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454856.1 KEGG: cal:orf19.4384 1.2e-15 HXT10; fructose symporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001454857.1 KEGG: hma:rrnAC0094 3.6e-05 ydiS; flavoprotein probably electron transport K00313; COG: COG2440 Ferredoxin-like protein; Psort location: cytoplasmic, score: 23 YP_001454858.1 FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction YP_001454859.1 involved in electron transfer during carnitine metabolism YP_001454860.1 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase YP_001454861.1 Psort location: nuclear, score: 23 YP_001454862.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism YP_001454863.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA YP_001454864.1 catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine YP_001454865.1 KEGG: stt:t0072 7.5e-246 caiC; probable crotonobetaine/carnitine-CoA ligase K02182; COG: COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; Psort location: cytoplasmic, score: 23 YP_001454866.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA YP_001454867.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities YP_001454868.1 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons YP_001454869.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_001454870.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001454871.1 Psort location: nuclear, score: 23 YP_001454872.1 Psort location: nuclear, score: 23 YP_001454873.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_001454874.1 KEGG: hma:rrnAC0517 2.0e-09 alaS2; alanyl-tRNA synthetase K01872; COG: COG2872 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain; Psort location: cytoplasmic, score: 23 YP_001454875.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001454876.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides YP_001454877.1 KEGG: reu:Reut_B5809 7.3e-65 5-carboxymethyl-2-hydroxymuconate delta-isomerase K01826; COG: COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway); Psort location: cytoplasmic, score: 23 YP_001454878.1 COG: COG3493 Na+/citrate symporter; Psort location: plasma membrane, score: 23 YP_001454879.1 Psort location: cytoplasmic, score: 23 YP_001454880.1 KEGG: eca:ECA2577 1.1e-164 citA; two-component sensor kinase K07700; COG: COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism; Psort location: endoplasmic reticulum, score: 9 YP_001454881.1 KEGG: btl:BALH_0517 1.4e-20 response regulator; COG: COG4565 Response regulator of citrate/malate metabolism; Psort location: cytoplasmic, score: 23 YP_001454882.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_001454883.1 KEGG: sfx:S0027 2.2e-72 slpA; probable FKBX-type 16kD peptidyl-prolyl cis-trans isomerase (a rotamase) K03774; COG: COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2; Psort location: cytoplasmic, score: 23 YP_001454884.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001454885.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_001454886.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_001454887.1 COG: COG0268 Ribosomal protein S20; Psort location: nuclear, score: 23 YP_001454888.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC YP_001454889.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH YP_001454890.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001454891.1 COG: NOG10237 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001454892.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001454893.1 Psort location: cytoplasmic, score: 23 YP_001454894.1 KEGG: dsy:DSY4088 0.0047 dmsC; putative anaerobic DMSO reductase chain C anchor subunit K00369; COG: COG1584 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001454895.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001454896.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis YP_001454897.1 KEGG: stt:t0007 8.0e-162 talB; transaldolase B K00616; COG: COG0176 Transaldolase; Psort location: cytoplasmic, score: 23 YP_001454898.1 KEGG: hpa:HPAG1_0925 1.4e-63 D-alanine glycine permease K01613; COG: COG1115 Na+/alanine symporter; Psort location: plasma membrane, score: 23 YP_001454899.1 COG: COG3022 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001454900.1 Psort location: nuclear, score: 23 YP_001454901.1 COG: NOG10264 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454902.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_001454903.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_001454904.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_001454905.1 member of the SPOUT superfamily of methyltransferases YP_001454906.1 KEGG: eci:UTI89_C5174 6.1e-125 arcA; ArcA transcriptional dual regulator K07773; COG: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001454907.1 Psort location: mitochondrial, score: 23 YP_001454908.1 COG: COG3045 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001454909.1 KEGG: bat:BAS3585 8.3e-09 Ada regulatory protein/6-O-methylguanine-DNA methyltransferase K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001454910.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate YP_001454911.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog YP_001454912.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription YP_001454913.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan YP_001454914.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_001454915.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide YP_001454916.1 Psort location: cytoplasmic, score: 23 YP_001454917.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001454918.1 Psort location: cytoplasmic, score: 23 YP_001454919.1 catalyzes the formation of serine from O-phosphoserine YP_001454920.1 KEGG: ece:Z5988 8.8e-101 putative lipoate-protein ligase A K03800:K07186; COG: COG3726 Uncharacterized membrane protein affecting hemolysin expression; Psort location: endoplasmic reticulum, score: 9 YP_001454921.1 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins YP_001454922.1 COG: NOG11500 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001454923.1 member of the periplasmic pilus chaperone family of proteins YP_001454924.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001454925.1 Psort location: extracellular, including cell wall, score: 9 YP_001454926.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_001454927.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_001454928.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate YP_001454929.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_001454930.1 COG: NOG06143 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454931.1 KEGG: vfi:VFA0962 1.2e-71 pyruvate formate-lyase activating enzyme K04069; COG: COG1180 Pyruvate-formate lyase-activating enzyme; Psort location: cytoplasmic, score: 23 YP_001454932.1 KEGG: stm:STM4564 3.6e-111 yjjV; putative hydrolase K03424; COG: COG0084 Mg-dependent DNase; Psort location: cytoplasmic, score: 23 YP_001454933.1 KEGG: vfi:VFA0008 3.2e-39 phospholipase; COG: COG4667 Predicted esterase of the alpha-beta hydrolase superfamily; Psort location: cytoplasmic, score: 23 YP_001454934.1 COG: NOG16919 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001454935.1 KEGG: hin:HI0574 0.0062 fkpA; probable fkbp-type peptidyl-prolyl cis-trans isomerase (PPIase) (ROTAMase) K03772; COG: COG2823 Predicted periplasmic or secreted lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001454936.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_001454937.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily YP_001454938.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18 YP_001454939.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_001454940.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit YP_001454941.1 Psort location: nuclear, score: 23 YP_001454942.1 Psort location: mitochondrial, score: 23 YP_001454943.1 COG: NOG09784 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001454944.1 KEGG: ava:Ava_3170 3.1e-25 putative diguanylate cyclase (GGDEF domain) K02488; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 23 YP_001454945.1 KEGG: gbe:GbCGDNIH1_2380 0.00064 ferric hydroxamate reductase FhuF K00521; COG: COG4114 Uncharacterized Fe-S protein; Psort location: cytoplasmic, score: 23 YP_001454946.1 KEGG: eca:ECA2488 4.3e-115 PTS system, cellobiose-specific IIc component K02761; COG: COG1455 Phosphotransferase system cellobiose-specific component IIC; Psort location: plasma membrane, score: 23 YP_001454947.1 Psort location: cytoplasmic, score: 23 YP_001454948.1 KEGG: bcl:ABC2234 2.8e-08 proS, pro; prolyl-tRNA synthetase K01881; COG: COG2606 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001454949.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin YP_001454950.1 COG: NOG09075 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454951.1 COG: COG2966 Uncharacterized conserved protein; Psort location: endoplasmic reticulum, score: 9 YP_001454952.1 COG: COG3610 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001454953.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' YP_001454954.1 acts to load the DnaB helicase onto the initiation site during DNA replication YP_001454955.1 COG: NOG12172 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001454956.1 catalyzes the transfer of phosphoglycerol to the glucan backbone YP_001454957.1 KEGG: reh:H16_A0240 6.9e-14 acetyltransferase (GNAT) family K00680; COG: NOG16606 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454958.1 KEGG: syn:sll1871 1.5e-07 hik6; two-component sensor histidine kinase K02486; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001454959.1 COG: COG1966 Carbon starvation protein, predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001454960.1 COG: COG2879 Uncharacterized small protein; Psort location: mitochondrial, score: 23 YP_001454961.1 KEGG: reh:H16_A0195 3.9e-59 putative GTPase (G3E family); COG: COG0523 Putative GTPases (G3E family); Psort location: cytoplasmic, score: 23 YP_001454962.1 COG: NOG06307 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001454963.1 COG: COG1566 Multidrug resistance efflux pump; Psort location: endoplasmic reticulum, score: 9 YP_001454964.1 KEGG: bja:bll2512 0.0077 putative acetyltransferase K03828; COG: COG1846 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001454965.1 COG: COG5457 Uncharacterized conserved small protein; Psort location: cytoplasmic, score: 23 YP_001454966.1 KEGG: bur:Bcep18194_B1266 1.4e-79 transcriptional regulator, GntR family with aminotransferase activity K00825; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: mitochondrial, score: 23 YP_001454967.1 COG: COG5464 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001454968.1 Psort location: cytoplasmic, score: 23 YP_001454969.1 KEGG: shn:Shewana3_1692 0.00084 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001454970.1 KEGG: sfl:SF3053 3.6e-159 metC; cystaTHIonine beta-lyase K01760; COG: COG0626 CystaTHIonine beta-lyases/cystaTHIonine gamma-synthases; Psort location: cytoplasmic, score: 23 YP_001454971.1 KEGG: eci:UTI89_C4668 9.3e-26 gltP; glutamate-aspartate symport protein K03309; COG: COG1301 Na+/H+-dicarboxylate symporters; Psort location: endoplasmic reticulum, score: 9 YP_001454972.1 KEGG: shn:Shewana3_3435 4.0e-08 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001454973.1 COG: COG2733 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001454974.1 KEGG: eci:UTI89_C5045 1.4e-187 yjiM; hypothetical protein YjiM K04111; COG: COG1775 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB; Psort location: cytoplasmic, score: 23 YP_001454975.1 KEGG: eci:UTI89_C5044 2.4e-114 yjiL; hypothetical protein YjiL K04111; COG: COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain); Psort location: cytoplasmic, score: 23 YP_001454976.1 Psort location: cytoplasmic, score: 23 YP_001454977.1 KEGG: eci:UTI89_C5041 9.0e-147 yjiJ; hypothetical protein YjiJ K00403; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001454978.1 Psort location: nuclear, score: 23 YP_001454979.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001454980.1 Psort location: cytoplasmic, score: 23 YP_001454981.1 Psort location: mitochondrial, score: 23 YP_001454982.1 COG: COG0814 Amino acid permeases; Psort location: plasma membrane, score: 23 YP_001454983.1 catalyzes the formation of phenol and pyruvate from tyrosine YP_001454984.1 COG: COG3177 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001454985.1 KEGG: nme:NMB1289 1.9e-50 type II restriction enzyme, putative K01155; COG: NOG14036 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454986.1 KEGG: plu:plu0338 2.7e-193 dcm; DNA-cytosine methyltransferase K00558; COG: COG0270 Site-specific DNA methylase; Psort location: cytoplasmic, score: 23 YP_001454987.1 Psort location: nuclear, score: 23 YP_001454988.1 KEGG: chu:CHU_1556 4.2e-11 DNA helicase K01529; COG: COG1112 Superfamily I DNA and RNA helicases and helicase subunits; Psort location: nuclear, score: 23 YP_001454989.1 COG: COG3440 Predicted restriction endonuclease; Psort location: cytoplasmic, score: 23 YP_001454990.1 Psort location: cytoplasmic, score: 23 YP_001454991.1 COG: NOG32955 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001454992.1 COG: COG3311 Predicted transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001454993.1 Psort location: nuclear, score: 23 YP_001454994.1 COG: NOG06299 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454995.1 COG: NOG06090 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454996.1 COG: NOG06090 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001454997.1 Psort location: cytoplasmic, score: 23 YP_001454998.1 COG: NOG17828 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001454999.1 Psort location: cytoplasmic, score: 23 YP_001455000.1 COG: NOG18931 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001455001.1 KEGG: psp:PSPPH_3207 0.0054 topA; DNA topoisomerase I K03168; COG: NOG18931 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001455002.1 Psort location: mitochondrial, score: 23 YP_001455003.1 Psort location: cytoplasmic, score: 23 YP_001455004.1 COG: NOG06091 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455005.1 COG: NOG06092 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455006.1 Psort location: extracellular, including cell wall, score: 9 YP_001455007.1 COG: NOG06088 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001455008.1 COG: NOG06088 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001455009.1 COG: COG1479 Uncharacterized conserved protein; Psort location: nuclear, score: 23 YP_001455010.1 COG: NOG17352 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001455011.1 Psort location: cytoplasmic, score: 23 YP_001455012.1 KEGG: fnu:FN0522 1.8e-10 exonuclease SBCC K03546; COG: COG0419 ATPase involved in DNA repair; Psort location: mitochondrial, score: 23 YP_001455013.1 KEGG: fnu:FN0444 1.0e-05 phosphoadenosine phosphosulfate reductase K00390; COG: COG0175 3-phosphoadenosine 5-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001455014.1 COG: NOG09812 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455015.1 KEGG: vfi:VFB02 1.7e-24 traC; DNA primase TraC; COG: COG4227 Antirestriction protein; Psort location: cytoplasmic, score: 23 YP_001455016.1 KEGG: vfi:VFB02 2.8e-24 traC; DNA primase TraC; COG: COG4227 Antirestriction protein; Psort location: cytoplasmic, score: 23 YP_001455017.1 COG: NOG08745 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455018.1 COG: NOG08745 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455019.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001455020.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001455021.1 Psort location: cytoplasmic, score: 23 YP_001455022.1 Psort location: cytoplasmic, score: 23 YP_001455023.1 COG: NOG07983 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455024.1 Psort location: cytoplasmic, score: 23 YP_001455025.1 COG: COG4928 Predicted P-loop ATPase; Psort location: cytoplasmic, score: 23 YP_001455026.1 Psort location: endoplasmic reticulum, score: 9 YP_001455027.1 COG: COG0535 Predicted Fe-S oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001455028.1 KEGG: syg:sync_2368 0.0053 arylsulfatase regulator; COG: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); Psort location: cytoplasmic, score: 23 YP_001455029.1 Psort location: cytoplasmic, score: 23 YP_001455030.1 Psort location: endoplasmic reticulum, score: 9 YP_001455031.1 Psort location: cytoplasmic, score: 23 YP_001455032.1 Psort location: nuclear, score: 23 YP_001455033.1 COG: NOG11714 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001455034.1 Psort location: extracellular, including cell wall, score: 9 YP_001455035.1 Psort location: endoplasmic reticulum, score: 9 YP_001455036.1 Psort location: cytoplasmic, score: 23 YP_001455037.1 COG: NOG23803 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455038.1 Psort location: mitochondrial, score: 23 YP_001455039.1 KEGG: pcr:Pcryo_1407 1.9e-09 DNA polymerase III, subunits gamma and tau K00961; COG: NOG10802 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001455040.1 Psort location: cytoplasmic, score: 23 YP_001455041.1 COG: NOG17703 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001455042.1 COG: COG4688 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001455043.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001455044.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001455045.1 COG: COG3311 Predicted transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001455046.1 Psort location: nuclear, score: 23 YP_001455047.1 COG: NOG07910 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455048.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001455049.1 KEGG: eci:UTI89_C4876 3.3e-172 yjgB; putative oxidoreductase K00100; COG: COG1064 Zn-dependent alcohol dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001455050.1 KEGG: reh:H16_A0917 2.1e-163 predicted ATPase K01529; COG: COG0433 Predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001455051.1 COG: COG0795 Predicted permeases; Psort location: endoplasmic reticulum, score: 9 YP_001455052.1 COG: COG0795 Predicted permeases; Psort location: endoplasmic reticulum, score: 9 YP_001455053.1 Psort location: mitochondrial, score: 23 YP_001455054.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_001455055.1 Psort location: cytoplasmic, score: 23 YP_001455056.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_001455057.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001455058.1 Psort location: cytoplasmic, score: 23 YP_001455059.1 COG: NOG27069 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455060.1 COG: NOG23016 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455061.1 Psort location: endoplasmic reticulum, score: 9 YP_001455062.1 Psort location: mitochondrial, score: 23 YP_001455063.1 COG: NOG23016 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455064.1 KEGG: stm:STM4473 2.4e-75 yjgM; putative acetyltransferase K03828; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001455065.1 COG: COG3076 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001455066.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase; when both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III YP_001455067.1 COG: COG2731 Beta-galactosidase, beta subunit; Psort location: cytoskeletal, score: 9 YP_001455068.1 Psort location: cytoplasmic, score: 23 YP_001455069.1 Psort location: extracellular, including cell wall, score: 9 YP_001455070.1 catalyzes the degradation of arginine to citruline and ammonia YP_001455071.1 reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_001455072.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway YP_001455073.1 COG: COG1288 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001455074.1 Psort location: cytoplasmic, score: 23 YP_001455075.1 COG: COG1438 Arginine repressor; Psort location: cytoplasmic, score: 23 YP_001455076.1 COG: NOG18556 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455077.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_001455078.1 involved in the allosteric regulation of aspartate carbamoyltransferase YP_001455079.1 KEGG: ape:APE_1501.1 2.9e-22 ribonuclease UK114; COG: COG0251 Putative translation initiation inhibitor, yjgF family; Psort location: cytoplasmic, score: 23 YP_001455080.1 COG: COG1593 TRAP-type C4-dicarboxylate transport system, large permease component; Psort location: plasma membrane, score: 23 YP_001455081.1 COG: COG3090 TRAP-type C4-dicarboxylate transport system, small permease component; Psort location: endoplasmic reticulum, score: 9 YP_001455082.1 P-type ATPase involved in magnesium influx YP_001455083.1 Psort location: nuclear, score: 23 YP_001455084.1 Psort location: mitochondrial, score: 23 YP_001455085.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon YP_001455086.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001455087.1 KEGG: stm:STM4453 2.1e-282 treC; trehalose-6-phosphate hydrolase K01226; COG: COG0366 Glycosidases; Psort location: cytoplasmic, score: 23 YP_001455088.1 COG: NOG06222 non supervised orthologous group; Psort location: cytoskeletal, score: 9 YP_001455089.1 KEGG: pab:PAB1222 0.00045 hps; D-arabino 3-hexulose 6-phosphate formaldehyde lyase K08093; COG: COG1737 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001455090.1 Psort location: nuclear, score: 23 YP_001455091.1 KEGG: vvy:VVA1395 5.3e-165 phosphotransferase system, fructose-specific IIC component K02769:K02770; COG: COG1299 Phosphotransferase system, fructose-specific IIC component; Psort location: endoplasmic reticulum, score: 9 YP_001455092.1 KEGG: lmf:LMOf2365_0421 1.5e-114 glycosyl hydrolase, family 38 K01191; COG: COG0383 Alpha-mannosidase; Psort location: cytoplasmic, score: 23 YP_001455093.1 KEGG: vvy:VVA1393 6.5e-160 sucrose phosphorylase related protein K00690; COG: COG0366 Glycosidases; Psort location: cytoplasmic, score: 23 YP_001455094.1 KEGG: vvy:VVA1392 3.8e-36 PTS fructose-specific enzyme IIA component homolog K02768; COG: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); Psort location: cytoplasmic, score: 23 YP_001455095.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_001455096.1 Psort location: cytoplasmic, score: 23 YP_001455097.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions YP_001455098.1 KEGG: spk:MGAS9429_Spy1126 9.9e-32 PTS system, mannitol (cryptic)-specific IIA component K00890; COG: COG4668 Mannitol/fructose-specific phosphotransferase system, IIA domain; Psort location: cytoplasmic, score: 23 YP_001455099.1 COG: NOG08125 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455100.1 KEGG: efa:EF0838 4.3e-92 pyridoxal phosphate-dependent enzyme, putative K01042; COG: COG1921 Selenocysteine synthase [seryl-tRNASer selenium transferase]; Psort location: cytoplasmic, score: 23 YP_001455101.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides YP_001455102.1 KEGG: rpa:RPA1257 0.0064 cobS; possible cobalamin (5'-phosphate) synthase K02233; COG: NOG08746 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001455103.1 KEGG: reh:H16_A3130 0.0057 pntAb3; NAD(P) transhydrogenase subunit alpha 2 K00323; COG: NOG07923 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001455104.1 COG: NOG18555 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455105.1 COG: NOG11467 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455106.1 COG: NOG18554 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455107.1 Psort location: cytoplasmic, score: 23 YP_001455108.1 KEGG: eco:b4236 1.5e-41 cybC; cytochrome b562, truncated (pseudogene); COG: COG3783 Soluble cytochrome b562; Psort location: extracellular, including cell wall, score: 9 YP_001455109.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD YP_001455110.1 COG: COG3028 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001455111.1 Psort location: nuclear, score: 23 YP_001455112.1 KEGG: ece:Z5843 1.0e-232 yjfG; putative ligase K02558; COG: COG0773 UDP-N-acetylmuramate-alanine ligase; Psort location: cytoplasmic, score: 23 YP_001455113.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_001455114.1 KEGG: ypa:YPA_2290 9.5e-05 hypothetical protein K07642; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001455115.1 membrane component of a putative sugar ABC transporter system YP_001455116.1 KEGG: msm:MSMEG_1710 1.5e-75 ribose transport system permease protein RbsC; COG: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001455117.1 KEGG: ecc:c5326 4.2e-252 ytfR; putative ATP-binding component of a transport system K02056; COG: COG1129 ABC-type sugar transport system, ATPase component; Psort location: endoplasmic reticulum, score: 9 YP_001455118.1 KEGG: msm:MSMEG_3095 7.9e-29 D-ribose-binding periplasmic protein; COG: COG1879 ABC-type sugar transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001455119.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_001455120.1 Psort location: cytoplasmic, score: 23 YP_001455121.1 KEGG: eci:UTI89_C0121 8.8e-53 usp; uropathogenic specific protein K01150; COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: cytoplasmic, score: 23 YP_001455122.1 Psort location: cytoplasmic, score: 23 YP_001455123.1 COG: COG2105 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001455124.1 KEGG: bmf:BAB1_0046 2.7e-14 family of unknown function DUF490 K01076; COG: COG2911 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001455125.1 COG: COG0729 Outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001455126.1 KEGG: sfl:SF4268 8.0e-91 msrA; peptide meTHIonine sulfoxide reductase K07304; COG: COG0225 Peptide meTHIonine sulfoxide reductase; Psort location: cytoplasmic, score: 23 YP_001455127.1 KEGG: hpa:HPAG1_1423 1.9e-41 putative integral membrane protein with a TlyC-like hemolysin domain K00088; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: endoplasmic reticulum, score: 9 YP_001455128.1 COG: NOG17567 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001455129.1 COG: COG3054 Predicted transcriptional regulator; Psort location: nuclear, score: 23 YP_001455130.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate YP_001455131.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate YP_001455132.1 COG: COG1733 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001455133.1 KEGG: eci:UTI89_C4820 1.4e-118 ytfG; hypothetical protein YtfG; COG: COG0702 Predicted nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001455134.1 Psort location: cytoplasmic, score: 23 YP_001455135.1 KEGG: bce:BC3740 3.1e-11 ADA regulatory protein K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001455136.1 KEGG: ssn:SSO_3622 0.0091 uhpB, uhpA; sensor histidine protein kinase phosphorylates UhpA K07675; COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: endoplasmic reticulum, score: 23 YP_001455137.1 KEGG: bca:BCE_1090 3.2e-07 sensor histidine kinase/response regulator K03407; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001455138.1 Involved in anaerobic NO protection and iron metabolism YP_001455139.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine YP_001455140.1 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides YP_001455141.1 KEGG: pen:PSEEN0463 0.00012 peptidase, M23/M37 family K01423; COG: COG3061 Cell envelope opacity-associated protein A; Psort location: nuclear, score: 23 YP_001455142.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001455143.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001455144.1 Psort location: cytoplasmic, score: 23 YP_001455145.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001455146.1 binds single-stranded DNA at the primosome assembly site YP_001455147.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001455148.1 Psort location: cytoplasmic, score: 23 YP_001455149.1 Psort location: cytoplasmic, score: 23 YP_001455150.1 COG: NOG11317 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455151.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_001455152.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway YP_001455153.1 Psort location: cytoplasmic, score: 23 YP_001455154.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization YP_001455155.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_001455156.1 Psort location: nuclear, score: 23 YP_001455157.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_001455158.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_001455159.1 Psort location: cytoplasmic, score: 23 YP_001455160.1 KEGG: spi:MGAS10750_Spy0162 7.6e-118 metal-dependent hydrolase; COG: COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold; Psort location: cytoplasmic, score: 23 YP_001455161.1 negative regulator of ulaG and ulaABCDEF YP_001455162.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo YP_001455163.1 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility YP_001455164.1 COG: NOG11343 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455165.1 Psort location: cytoplasmic, score: 23 YP_001455166.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA YP_001455167.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA YP_001455168.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs YP_001455169.1 negatively regulates the transcription of genes upregulated by nitrosative stress YP_001455170.1 Psort location: nuclear, score: 23 YP_001455171.1 Psort location: cytoplasmic, score: 23 YP_001455172.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_001455173.1 Psort location: nuclear, score: 23 YP_001455174.1 Psort location: cytoplasmic, score: 23 YP_001455175.1 with HflK inhibits proteolysis of lambda cII protein by FtsH YP_001455176.1 with HflC inhibits proteolysis of lambda cII protein by FtsH YP_001455177.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein YP_001455178.1 Stimulates the elongation of poly(A) tails YP_001455179.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_001455180.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_001455181.1 KEGG: ecp:ECP_4414 6.7e-206 N-acetylmuramoyl-L-alanine amidase AmiB precursor K01448; COG: COG0860 N-acetylmuramoyl-L-alanine amidase; Psort location: extracellular, including cell wall, score: 9 YP_001455182.1 possibly involved in cell wall synthesis YP_001455183.1 KEGG: reh:H16_A1504 1.4e-63 predicted sugar kinase K00924; COG: COG0063 Predicted sugar kinase; Psort location: cytoplasmic, score: 23 YP_001455184.1 COG: COG1600 Uncharacterized Fe-S protein; Psort location: cytoplasmic, score: 23 YP_001455185.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_001455186.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_001455187.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine YP_001455188.1 KEGG: rno:113960 5.0e-08 Cdc42bpb; Cdc42 binding protein kinase beta K08286; COG: COG3264 Small-conductance mechanosensitive channel; Psort location: plasma membrane, score: 23 YP_001455189.1 KEGG: eci:UTI89_C0120 0.0063 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001455190.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001455191.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001455192.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001455193.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001455194.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane YP_001455195.1 lipocalin; globomycin-sensitive outer membrane lipoprotein YP_001455196.1 member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations YP_001455197.1 COG: COG2771 DNA-binding HTH domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001455198.1 COG: COG5510 Predicted small secreted protein; Psort location: endoplasmic reticulum, score: 9 YP_001455199.1 Psort location: cytoplasmic, score: 23 YP_001455200.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001455201.1 KEGG: eci:UTI89_C4744 1.3e-168 yjeK; hypothetical protein YjeK K01843; COG: COG1509 Lysine 2,3-aminomutase; Psort location: cytoplasmic, score: 23 YP_001455202.1 COG: NOG06800 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001455203.1 Psort location: nuclear, score: 23 YP_001455204.1 COG: NOG09783 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455205.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001455206.1 KEGG: ftu:FTT1695 3.2e-23 groS, htpA; chaperonin protein, groES K04078; COG: COG0234 Co-chaperonin GroES (HSP10); Psort location: cytoplasmic, score: 23 YP_001455207.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function YP_001455208.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein YP_001455209.1 catalyzes the formation of fumarate from aspartate YP_001455210.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB YP_001455211.1 Psort location: nuclear, score: 23 YP_001455212.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals YP_001455213.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm YP_001455214.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001455215.1 COG: COG4405 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001455216.1 Psort location: mitochondrial, score: 23 YP_001455217.1 inversion of on/off regulator of fimA YP_001455218.1 inversion of on/off regulator of fimA YP_001455219.1 KEGG: lpl:lp_3093 0.0072 muramidase (putative) K01185; COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001455220.1 Psort location: cytoplasmic, score: 23 YP_001455221.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001455222.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: nuclear, score: 23 YP_001455223.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: golgi, score: 9 YP_001455224.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: endoplasmic reticulum, score: 9 YP_001455225.1 KEGG: ava:Ava_4160 0.00018 VCBS K01317; COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001455226.1 COG: NOG06796 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455227.1 KEGG: vfi:VF0087 3.0e-14 sensory transduction protein kinase; COG: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; Psort location: mitochondrial, score: 23 YP_001455228.1 KEGG: vfi:VFA0360 6.0e-09 sensory transduction protein kinase; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001455229.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_001455230.1 COG: COG3069 C4-dicarboxylate transporter; Psort location: plasma membrane, score: 23 YP_001455231.1 COG: COG1737 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001455232.1 KEGG: vvy:VV2243 2.9e-148 adenylosuccinate lyase K01857; COG: COG0015 Adenylosuccinate lyase; Psort location: cytoplasmic, score: 23 YP_001455233.1 Psort location: endoplasmic reticulum, score: 9 YP_001455234.1 COG: COG3203 Outer membrane protein (porin); Psort location: extracellular, including cell wall, score: 9 YP_001455235.1 COG: NOG21777 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455236.1 Psort location: mitochondrial, score: 23 YP_001455237.1 COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: cytoplasmic, score: 23 YP_001455238.1 Psort location: cytoplasmic, score: 23 YP_001455240.1 KEGG: efa:EF1922 0.00036 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001455241.1 COG: COG4154 Fucose dissimilation pathway protein FucU; Psort location: cytoplasmic, score: 23 YP_001455242.1 KEGG: mta:Moth_0426 3.0e-43 short-chain dehydrogenase/reductase SDR K00059; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001455243.1 KEGG: mxa:MXAN_1671 0.0048 V-type H(+)-translocating pyrophosphatase K01507; COG: COG1593 TRAP-type C4-dicarboxylate transport system, large permease component; Psort location: plasma membrane, score: 23 YP_001455244.1 COG: COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component; Psort location: endoplasmic reticulum, score: 9 YP_001455245.1 KEGG: ecc:c1968 7.5e-214 ydfI; hypothetical oxidoreductase YdfI; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001455246.1 KEGG: eci:UTI89_C4210 6.2e-13 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001455247.1 KEGG: sha:SH2648 7.1e-131 hypothetical protein K01812; COG: COG1904 Glucuronate isomerase; Psort location: cytoplasmic, score: 23 YP_001455248.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_001455249.1 Psort location: mitochondrial, score: 23 YP_001455250.1 COG: COG4256 Hemin uptake protein; Psort location: endoplasmic reticulum, score: 9 YP_001455251.1 KEGG: shn:Shewana3_3063 0.00079 phosphatidylglycerophosphatase K01094; COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: extracellular, including cell wall, score: 9 YP_001455252.1 COG: COG3720 Putative heme degradation protein; Psort location: cytoplasmic, score: 23 YP_001455253.1 COG: COG4558 ABC-type hemin transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001455254.1 COG: COG0609 ABC-type Fe3+-siderophore transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001455255.1 with HmuTU is involved in the transport of hemin YP_001455256.1 COG: COG2215 ABC-type uncharacterized transport system, permease component; Psort location: endoplasmic reticulum, score: 23 YP_001455257.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration YP_001455258.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration YP_001455259.1 Psort location: cytoplasmic, score: 23 YP_001455260.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters YP_001455261.1 KEGG: stt:t4207 1.9e-286 fumB; fumarate hydratase class I K01676; COG: COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain; Psort location: cytoplasmic, score: 23 YP_001455262.1 Psort location: nuclear, score: 23 YP_001455263.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division YP_001455264.1 response regulator in two-component regulatory system with BasS YP_001455265.1 KEGG: sec:SC4170 3.7e-157 basS, basR; sensory kinase in two-component regulatory system with BasR K07643; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001455266.1 KEGG: cal:orf19.2425 1.4e-05 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001455267.1 Psort location: cytoplasmic, score: 23 YP_001455268.1 Psort location: cytoplasmic, score: 23 YP_001455269.1 transports degraded pectin products into the bacterial cell YP_001455270.1 COG: NOG06779 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455271.1 KEGG: reh:H16_A0378 0.0039 predicted GTPase K01529; COG: COG0699 Predicted GTPases (dynamin-related); Psort location: cytoplasmic, score: 23 YP_001455272.1 Psort location: cytoplasmic, score: 23 YP_001455273.1 Psort location: mitochondrial, score: 23 YP_001455274.1 Psort location: cytoplasmic, score: 23 YP_001455275.1 KEGG: eci:UTI89_C4702 2.4e-59 phnA; hypothetical protein PhnA K06193; COG: COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism; Psort location: mitochondrial, score: 23 YP_001455276.1 COG: COG2764 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001455277.1 KEGG: reh:H16_B1296 7.3e-65 phnC1; ABC-type transporter, ATPase component: PhnT family; COG: COG3638 ABC-type phosphate/phosphonate transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001455278.1 COG: COG3221 ABC-type phosphate/phosphonate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001455279.1 KEGG: baa:BA_0884 1.1e-07 binding-protein-dependent transport systems inner membrane component K00294; COG: COG3639 ABC-type phosphate/phosphonate transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001455280.1 may be involved in phosphonate uptake and biodegradation YP_001455281.1 COG: COG3624 Uncharacterized enzyme of phosphonate metabolism; Psort location: cytoplasmic, score: 23 YP_001455282.1 COG: COG3625 Uncharacterized enzyme of phosphonate metabolism; Psort location: cytoplasmic, score: 23 YP_001455283.1 COG: COG3626 Uncharacterized enzyme of phosphonate metabolism; Psort location: cytoplasmic, score: 23 YP_001455284.1 COG: COG3627 Uncharacterized enzyme of phosphonate metabolism; Psort location: cytoplasmic, score: 23 YP_001455285.1 KEGG: reh:H16_B1284 1.9e-80 phnK; ABC-type phosphonate transport system, ATPase component; COG: COG4107 ABC-type phosphonate transport system, ATPase component; Psort location: endoplasmic reticulum, score: 9 YP_001455286.1 KEGG: reh:H16_B1283 3.2e-64 phnL; ABC-type phosphonate transport system, ATPase component; COG: COG4778 ABC-type phosphonate transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001455287.1 KEGG: sto:ST2546 4.6e-05 N-acetylglucosamine-6-phosphate deacetylase K01443; COG: COG3454 Metal-dependent hydrolase involved in phosphonate metabolism; Psort location: endoplasmic reticulum, score: 9 YP_001455288.1 KEGG: rde:RD1_1528 2.9e-21 nucleoside phosphorylase, C -terminal domain, putative; COG: COG3709 Uncharacterized component of phosphonate metabolism; Psort location: cytoplasmic, score: 23 YP_001455289.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role YP_001455290.1 Psort location: cytoplasmic, score: 23 YP_001455291.1 KEGG: gbe:GbCGDNIH1_1079 7.9e-05 metal-dependent hydrolase; COG: COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I; Psort location: cytoplasmic, score: 23 YP_001455292.1 KEGG: ath:At3g25840 5.4e-05 K9I22.6; protein kinase family protein K08827; COG: NOG10268 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455293.1 COG: NOG33784 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455294.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity YP_001455295.1 Psort location: cytoplasmic, score: 23 YP_001455296.1 involved in rpiB and als operon repression YP_001455297.1 KEGG: msm:MSMEG_3095 2.5e-23 D-ribose-binding periplasmic protein; COG: COG1879 ABC-type sugar transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001455298.1 with AlsBC acts to import allose into the cell; AlsA contain 2 ATP-binding domains YP_001455299.1 KEGG: msm:MSMEG_4171 2.7e-51 ribose transport system permease protein RbsC; COG: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; Psort location: plasma membrane, score: 23 YP_001455300.1 KEGG: eci:UTI89_C4681 1.3e-113 yjcU; D-allulose-6-phosphate 3-epimerase; COG: COG0036 Pentose-5-phosphate-3-epimerase; Psort location: cytoplasmic, score: 23 YP_001455301.1 KEGG: ecp:ECP_4326 2.7e-131 D-allose kinase K00881; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: cytoplasmic, score: 23 YP_001455302.1 KEGG: psp:PSPPH_3276 1.4e-71 sensory box sensor histidine kinase/response regulator; COG: COG0784 FOG: CheY-like receiver; Psort location: endoplasmic reticulum, score: 9 YP_001455303.1 Psort location: nuclear, score: 23 YP_001455304.1 KEGG: ecs:ECs5073 2.0e-243 putative ATP-binding component of sugar ABC transporter K02056; COG: COG1129 ABC-type sugar transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001455305.1 KEGG: msm:MSMEG_4171 1.6e-60 ribose transport system permease protein RbsC; COG: COG4158 Predicted ABC-type sugar transport system, permease component; Psort location: plasma membrane, score: 23 YP_001455306.1 Psort location: mitochondrial, score: 23 YP_001455307.1 KEGG: msm:MSMEG_3095 9.3e-26 D-ribose-binding periplasmic protein; COG: COG1879 ABC-type sugar transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001455308.1 COG: COG3822 ABC-type sugar transport system, auxiliary component; Psort location: cytoplasmic, score: 23 YP_001455309.1 KEGG: ecs:ECs5069 3.9e-137 putative fructose-bisphosphate aldolase K01624; COG: COG0191 Fructose/tagatose bisphosphate aldolase; Psort location: cytoplasmic, score: 23 YP_001455310.1 KEGG: stm:STM3885 2.2e-12 rbsK; ribokinase K00852; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001455311.1 KEGG: bur:Bcep18194_A5728 7.7e-38 two component transcriptional regulator, winged helix family; COG: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001455312.1 Psort location: cytoplasmic, score: 23 YP_001455313.1 KEGG: stm:STM4285 1.7e-72 fdhF; formate dehydrogenase K00123; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001455314.1 Psort location: cytoplasmic, score: 23 YP_001455315.1 KEGG: ecj:JW4040 4.1e-300 fdhF; formate dehydrogenase-H, selenopolypeptide subunit K00123; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001455316.1 KEGG: eci:UTI89_C1133 1.3e-15 hypothetical protein; COG: COG0790 FOG: TPR repeat, SEL1 subfamily; Psort location: extracellular, including cell wall, score: 9 YP_001455317.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system YP_001455318.1 Psort location: nuclear, score: 23 YP_001455319.1 KEGG: eci:UTI89_C4062 2.0e-06 yhjL; cellulose synthase operon protein C K00694; COG: COG4235 Cytochrome c biogenesis factor; Psort location: cytoplasmic, score: 23 YP_001455320.1 KEGG: stm:STM4281 5.4e-53 nrfE; putative methylase K04016; COG: COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes; Psort location: endoplasmic reticulum, score: 9 YP_001455321.1 with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552 YP_001455322.1 KEGG: pai:PAE2861 9.2e-19 molybdopterin oxidoreductase, membrane subunit K00185; COG: COG3301 Formate-dependent nitrite reductase, membrane component; Psort location: plasma membrane, score: 23 YP_001455323.1 KEGG: vfi:VF1552 4.8e-77 THIosulfate reductase electron transport subunit K04014; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: mitochondrial, score: 23 YP_001455324.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia YP_001455325.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552 YP_001455326.1 Psort location: nuclear, score: 23 YP_001455327.1 Psort location: cytoplasmic, score: 23 YP_001455328.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_001455329.1 KEGG: lic:LIC10289 0.0013 proton-translocating transhydrogenase subunit alpha 2 K00322; COG: COG3162 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001455330.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake YP_001455331.1 KEGG: btl:BALH_3309 6.9e-37 murein hydrolase export regulator K01238; COG: COG1346 Putative effector of murein hydrolase; Psort location: endoplasmic reticulum, score: 9 YP_001455332.1 KEGG: btk:BT9727_3424 7.9e-13 murein hydrolase exporter K06518; COG: COG1380 Putative effector of murein hydrolase LrgA; Psort location: endoplasmic reticulum, score: 23 YP_001455333.1 KEGG: shn:Shewana3_3435 1.3e-60 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001455334.1 Psort location: cytoplasmic, score: 23 YP_001455335.1 COG: COG1943 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001455336.1 COG: COG0025 NhaP-type Na+/H+ and K+/H+ antiporters; Psort location: plasma membrane, score: 23 YP_001455337.1 KEGG: bcz:BCZK0244 4.2e-62 guanine-hypoxanTHIne permease; xanTHIne/uracil permease family protein K06901; COG: COG2252 Permeases; Psort location: plasma membrane, score: 23 YP_001455338.1 KEGG: xcc:XCC2286 2.7e-58 gstA; glutaTHIone S-transferase K00799; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001455339.1 KEGG: eci:UTI89_C3737 1.8e-06 yhdM; Zn(II)-responsive regulator of ZntA; COG: COG0789 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001455340.1 regulates genes involved in response to oxidative stress YP_001455341.1 KEGG: eci:UTI89_C1702 1.3e-31 hypothetical protein; COG: COG4943 Predicted signal transduction protein containing sensor and EAL domains; Psort location: endoplasmic reticulum, score: 9 YP_001455342.1 COG: NOG13912 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455343.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor regulates the genes for iron dicitrate transport YP_001455344.1 with FecA forms the FecAR signal transduction system; ferric citrate binds FecA and transmits a signal across the outer membrane to FecR. FecR transmits a signal across the cytoplasmic membrane and activates the sigma 70 protein FecI that directs the RNA polymerase to express the fecABCDE operon YP_001455345.1 COG: COG4772 Outer membrane receptor for Fe3+-dicitrate; Psort location: extracellular, including cell wall, score: 9 YP_001455346.1 KEGG: stm:STM4281 0.0044 nrfE; putative methylase K04016; Psort location: nuclear, score: 23 YP_001455347.1 part of the ABC transporter involved in the uptake of citrate-dependent Fe(3+) YP_001455348.1 part of the FecBCDE citrate-dependent iron (III) transport system YP_001455349.1 Ferric citrate binds FecA and is transported across the outer membrane while transmits a signal across the cytoplasmic membrane protein FecR. FecR transmits a signal across the membrane and activates the cytoplasmic FecI that directs the RNA polymerase to express the fecABCDE operon (which encodes the ferric citrate outer membrane receptor and the ferric citrate ABC transporter), as well as fecIR. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter. YP_001455350.1 Part of the FecBCDE citrate-dependent iron (III) transport system YP_001455351.1 KEGG: yps:YPTB0594 0. putative Ca++ transporting P-type ATPase K01529; COG: COG0474 Cation transport ATPase; Psort location: plasma membrane, score: 23 YP_001455352.1 Psort location: mitochondrial, score: 23 YP_001455353.1 COG: COG0589 Universal stress protein UspA and related nucleotide-binding proteins; Psort location: cytoplasmic, score: 23 YP_001455354.1 binds to single stranded DNA and PriA helcase facilitate replication restart YP_001455355.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_001455356.1 COG: COG2315 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001455357.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity YP_001455358.1 KEGG: bps:BPSL0426 6.5e-89 dctB; C4-dicarboxylate transport sensor protein; COG: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; Psort location: endoplasmic reticulum, score: 9 YP_001455359.1 KEGG: eci:UTI89_C2502 5.5e-76 atoC; acetoacetate metabolism regulatory protein AtoC K07714; COG: COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains; Psort location: cytoplasmic, score: 23 YP_001455360.1 KEGG: ecc:c5039 3.1e-160 putative lactate dehydrogenase K00025; COG: COG2055 Malate/L-lactate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001455361.1 COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001455362.1 KEGG: eci:UTI89_C4635 1.0e-145 SucD, succinyl-CoA synthetase alpha chain K01902; COG: COG0074 Succinyl-CoA synthetase, alpha subunit; Psort location: cytoplasmic, score: 23 YP_001455363.1 KEGG: ecp:ECP_4277 6.7e-174 succinyl-CoA synthetase beta chain K01903; COG: COG0045 Succinyl-CoA synthetase, beta subunit; Psort location: cytoplasmic, score: 23 YP_001455364.1 KEGG: eci:UTI89_C4633 9.6e-198 subunit of 2-oxoglutarate dehydrogenase K00382; COG: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes; Psort location: cytoplasmic, score: 23 YP_001455365.1 KEGG: ecp:ECP_4275 3.2e-158 probable dihydrolipoamide succinyltransferase K00658; COG: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes; Psort location: cytoplasmic, score: 23 YP_001455366.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_001455367.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_001455368.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_001455369.1 Psort location: nuclear, score: 23 YP_001455370.1 unwinds double stranded DNA YP_001455371.1 KEGG: sty:STY4441 2.0e-158 qor; quinone oxidoreductase K00344; COG: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001455372.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia YP_001455373.1 Psort location: nuclear, score: 23 YP_001455374.1 KEGG: ssn:SSO_4229 2.6e-172 yjbN; hypothetical protein K05539; COG: COG0042 tRNA-dihydrouridine synthase; Psort location: cytoplasmic, score: 23 YP_001455375.1 COG: NOG36642 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455376.1 COG: NOG36642 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455378.1 KEGG: eci:UTI89_C0121 6.4e-50 usp; uropathogenic specific protein K01150; COG: NOG14030 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455379.1 Psort location: cytoplasmic, score: 23 YP_001455380.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB YP_001455381.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential YP_001455382.1 COG: COG0534 Na+-driven multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001455383.1 Psort location: mitochondrial, score: 23 YP_001455384.1 Represses a number of genes involved in the response to DNA damage YP_001455385.1 KEGG: sec:SC4115 1.5e-57 dgkA; diacylglycerol kinase K00901; COG: COG0818 Diacylglycerol kinase; Psort location: endoplasmic reticulum, score: 9 YP_001455386.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_001455387.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway YP_001455388.1 catalyzes the formation of 4-hydroxybenzoate from chorismate YP_001455389.1 KEGG: sbo:SBO_4078 8.1e-08 ubiC; chorismate lyase K03181; COG: COG3161 4-hydroxybenzoate synthetase (chorismate lyase); Psort location: cytoplasmic, score: 23 YP_001455390.1 KEGG: bcn:Bcen_5941 0.0046 dihydrolipoamide acetyltransferase K00658; COG: NOG06298 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455391.1 porin involved in the transport of maltose and maltodextrins YP_001455392.1 with malEFG is involved in import of maltose/maltodextrin YP_001455393.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis YP_001455394.1 Psort location: nuclear, score: 23 YP_001455395.1 with MalKGE is involved in maltose transport into the cell YP_001455396.1 with MalKFE is involved in the transport of maltose into the cell YP_001455397.1 COG: COG3223 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001455398.1 KEGG: pha:PSHAa2996 1.8e-13 carbohydrate O-acetyltransferase K00661; COG: COG0110 Acetyltransferase (isoleucine patch superfamily); Psort location: cytoplasmic, score: 23 YP_001455399.1 COG: NOG06257 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455400.1 Psort location: cytoplasmic, score: 23 YP_001455401.1 COG: NOG06780 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455402.1 COG: NOG06220 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001455403.1 COG: NOG14141 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455404.1 Psort location: cytoplasmic, score: 23 YP_001455405.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_001455406.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive YP_001455407.1 COG: COG0385 Predicted Na+-dependent transporter; Psort location: endoplasmic reticulum, score: 9 YP_001455408.1 Psort location: mitochondrial, score: 23 YP_001455409.1 COG: NOG14139 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001455410.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA YP_001455411.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family YP_001455412.1 COG: COG1283 Na+/phosphate symporter; Psort location: endoplasmic reticulum, score: 9 YP_001455413.1 Psort location: mitochondrial, score: 23 YP_001455414.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_001455415.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase YP_001455416.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol YP_001455417.1 KEGG: ecc:c4972 1.4e-228 aceA; isocitrate lyase K01637; COG: COG2224 Isocitrate lyase; Psort location: cytoplasmic, score: 23 YP_001455418.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle YP_001455419.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis YP_001455420.1 KEGG: eco:b4012 9.4e-65 yjaB; hypothetical protein K03827; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001455421.1 Psort location: nuclear, score: 23 YP_001455423.1 KEGG: eci:UTI89_C2925 0. clpB; heat shock protein K03695; COG: COG0542 ATPases with chaperone activity, ATP-binding subunit; Psort location: cytoplasmic, score: 23 YP_001455424.1 COG: COG1496 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001455425.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA YP_001455426.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline YP_001455427.1 associated with 30S ribosomal subunit; interferes with translation elongation YP_001455428.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_001455429.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis YP_001455430.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive YP_001455431.1 COG: NOG10259 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455432.1 COG: NOG17158 non supervised orthologous group; Psort location: golgi, score: 9 YP_001455433.1 KEGG: vfi:VFA0057 5.8e-17 sensor protein; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001455434.1 COG: COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; Psort location: extracellular, including cell wall, score: 9 YP_001455435.1 KEGG: btk:BT9727_4489 2.2e-19 cysJ; sulfite reductase [NADPH], flavoprotein, alpha subunit K00379; COG: COG3182 Uncharacterized iron-regulated membrane protein; Psort location: endoplasmic reticulum, score: 23 YP_001455436.1 Psort location: cytoplasmic, score: 23 YP_001455437.1 Psort location: endoplasmic reticulum, score: 9 YP_001455438.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001455439.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_001455440.1 Essential for efficient processing of 16S rRNA YP_001455441.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001455442.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins YP_001455443.1 KEGG: sat:SYN_00150 5.8e-05 heme export protein apocytochrome heme-lyase; COG: COG4137 ABC-type uncharacterized transport system, permease component; Psort location: plasma membrane, score: 23 YP_001455444.1 KEGG: ece:Z3906m 6.9e-204 yfjD; uncharacterized CBS domain-containing protein K00638; COG: COG4536 Putative Mg2+ and Co2+ transporter CorB; Psort location: endoplasmic reticulum, score: 9 YP_001455445.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_001455446.1 KEGG: ssn:SSO_2771 7.2e-138 yfjB; hypothetical protein K00858; COG: COG0061 Predicted sugar kinase; Psort location: nuclear, score: 23 YP_001455447.1 KEGG: yps:YPTB0915 9.1e-05 sbcC; putative ATP-dependent dsDNA exonuclease K03546; COG: COG0497 ATPase involved in DNA repair; Psort location: extracellular, including cell wall, score: 9 YP_001455448.1 COG: COG2913 Small protein A (tmRNA-binding); Psort location: extracellular, including cell wall, score: 9 YP_001455449.1 COG: COG2914 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001455450.1 KEGG: tfu:Tfu_1222 0.0037 actinorhodin polyketide synthase bifunctional cyclase/dehydratase K05554; COG: COG2867 Oligoketide cyclase/lipid transport protein; Psort location: cytoplasmic, score: 23 YP_001455451.1 COG: COG0691 tmRNA-binding protein; Psort location: mitochondrial, score: 23 YP_001455452.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001455453.1 KEGG: mpu:MYPU_6980 5.9e-26 pcrA; ATP-dependent helicase PcrA K03657; COG: COG0210 Superfamily I DNA and RNA helicases; Psort location: cytoplasmic, score: 23 YP_001455454.1 KEGG: fnu:FN0522 0.00027 exonuclease SBCC K03546; COG: COG3593 Predicted ATP-dependent endonuclease of the OLD family; Psort location: cytoplasmic, score: 23 YP_001455455.1 KEGG: sto:ST1504 0.0023 carbamoyl-phosphate synthase large chain K01955; COG: NOG15779 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455456.1 Psort location: cytoplasmic, score: 23 YP_001455457.1 Psort location: extracellular, including cell wall, score: 23 YP_001455458.1 Psort location: endoplasmic reticulum, score: 9 YP_001455459.1 Psort location: cytoplasmic, score: 23 YP_001455460.1 Psort location: cytoplasmic, score: 23 YP_001455461.1 Psort location: nuclear, score: 23 YP_001455462.1 Psort location: endoplasmic reticulum, score: 9 YP_001455463.1 Psort location: nuclear, score: 23 YP_001455464.1 KEGG: sth:STH413 0.00091 pyruvate dehydrogenase E2 K00627; COG: NOG10802 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001455465.1 COG: NOG23803 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455466.1 Psort location: extracellular, including cell wall, score: 9 YP_001455467.1 Psort location: cytoplasmic, score: 23 YP_001455468.1 COG: NOG17703 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001455469.1 COG: COG4688 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001455470.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001455471.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001455472.1 Psort location: cytoskeletal, score: 9 YP_001455473.1 Psort location: cytoplasmic, score: 23 YP_001455474.1 COG: NOG15335 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001455475.1 Psort location: nuclear, score: 23 YP_001455476.1 Psort location: cytoplasmic, score: 23 YP_001455477.1 COG: COG3477 Predicted periplasmic/secreted protein; Psort location: endoplasmic reticulum, score: 9 YP_001455478.1 Psort location: cytoplasmic, score: 23 YP_001455479.1 catalyzes the formation of diketo methylthiopentyl phosphate from methylribulose phosphate in the methionine salvage pathway YP_001455480.1 KEGG: gbe:GbCGDNIH1_2267 1.7e-51 2,3-diketo-5-methylTHIo-1-phosphopentanoate tautomerase K01112; COG: COG4229 Predicted enolase-phosphatase; Psort location: cytoplasmic, score: 23 YP_001455481.1 KEGG: psp:PSPPH_1815 1.0e-51 ARD/ARD'''' family protein K05915; COG: COG1791 Uncharacterized conserved protein, contains double-stranded beta-helix domain; Psort location: cytoplasmic, score: 23 YP_001455482.1 KEGG: eca:ECA3477 2.2e-136 methylTHIoribose-1-phosphate isomerase K08963; COG: COG0182 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family; Psort location: endoplasmic reticulum, score: 9 YP_001455483.1 phosphorylates methylthioribose to form methylthioribose-1-phosphate; involved in methionine salvage pathway YP_001455484.1 COG: COG5276 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001455485.1 Psort location: mitochondrial, score: 23 YP_001455486.1 Psort location: nuclear, score: 23 YP_001455487.1 KEGG: bpm:BURPS1710b_A0023 3.1e-10 ABC transporter, ATP-binding protein domain protein K02056; COG: COG1879 ABC-type sugar transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001455488.1 KEGG: msm:MSMEG_4171 1.1e-45 ribose transport system permease protein RbsC; COG: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; Psort location: plasma membrane, score: 23 YP_001455489.1 KEGG: eca:ECA2719 2.2e-184 ABC transporter, ATP-binding protein K02056; COG: COG1129 ABC-type sugar transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001455490.1 Psort location: nuclear, score: 23 YP_001455491.1 KEGG: azo:azo3685 1.7e-12 putative hybrid sensor and regulator protein; COG: COG2202 FOG: PAS/PAC domain; Psort location: endoplasmic reticulum, score: 9 YP_001455492.1 COG: COG3718 Uncharacterized enzyme involved in inositol metabolism; Psort location: cytoplasmic, score: 23 YP_001455493.1 KEGG: hne:HNE_2184 2.4e-73 iolE; 2-keto-myo-inositol dehydratase K01726; COG: COG1082 Sugar phosphate isomerases/epimerases; Psort location: cytoplasmic, score: 23 YP_001455494.1 KEGG: bpm:BURPS1710b_1831 2.4e-192 iolC; IolC protein K03338; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001455495.1 KEGG: bme:BMEI0661 2.5e-87 myo-inositol 2-dehydrogenase K00010; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001455496.1 KEGG: msm:MSMEG_4171 1.6e-60 ribose transport system permease protein RbsC; COG: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; Psort location: plasma membrane, score: 23 YP_001455497.1 KEGG: yps:YPTB1075 3.8e-242 ABC type sugar transporter with fused ATP-binding domains K02056; COG: COG1129 ABC-type sugar transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001455498.1 KEGG: msm:MSMEG_3095 3.5e-19 D-ribose-binding periplasmic protein; COG: COG1879 ABC-type sugar transport system, periplasmic component; Psort location: endoplasmic reticulum, score: 9 YP_001455499.1 KEGG: yps:YPTB1073 4.5e-152 putative myo-inositol 2-dehydrogenase K00010; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001455500.1 Psort location: nuclear, score: 23 YP_001455501.1 KEGG: ypm:YP_1136 4.9e-297 ilvB1; putative THIamine pyrophosphate-dependent protein K03336; COG: COG3962 Acetolactate synthase; Psort location: cytoplasmic, score: 23 YP_001455502.1 KEGG: ype:YPO2577 4.2e-236 putative methylmalonate-semialdehyde dehydrogenase K00140; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001455503.1 KEGG: bxe:Bxe_A3454 2.9e-09 glucokinase K00845; COG: COG1737 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001455504.1 COG: NOG14948 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001455505.1 KEGG: hpj:jhp1098 0.00052 polar amino acid transport system ATP-binding protein K02028; COG: COG1106 Predicted ATPases; Psort location: cytoplasmic, score: 23 YP_001455506.1 KEGG: tko:TK1596 0.0027 archaeal/vacuolar-type H+-ATPase, subunit H K02121; COG: KOG1075 FOG: Reverse transcriptase; Psort location: extracellular, including cell wall, score: 9 YP_001455507.1 KEGG: stt:t2678 1.2e-215 tctE; putative two-component system sensor kinase K07649; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001455508.1 KEGG: rha:RHA1_ro05622 3.8e-36 response regulator (protein-glutamate methylesterase) K07669; COG: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001455509.1 COG: COG3181 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001455510.1 COG: NOG11450 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001455511.1 COG: COG3333 Uncharacterized protein conserved in bacteria; Psort location: plasma membrane, score: 23 YP_001455512.1 KEGG: pca:Pcar_0758 1.3e-10 esterase/lipase-like K03928; COG: COG2267 Lysophospholipase; Psort location: endoplasmic reticulum, score: 9 YP_001455513.1 Psort location: mitochondrial, score: 23 YP_001455514.1 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution YP_001455515.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate YP_001455516.1 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent YP_001455517.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_001455518.1 KEGG: eci:UTI89_C0120 2.2e-72 aroP; aromatic amino acid transport protein AroP K03293; COG: COG1113 Gamma-aminobutyrate permease and related permeases; Psort location: plasma membrane, score: 23 YP_001455519.1 regulator of gab gene expression YP_001455520.1 COG: COG1652 Uncharacterized protein containing LysM domain; Psort location: cytoplasmic, score: 23 YP_001455521.1 KEGG: reh:H16_A0333 8.8e-14 rhodanese-related sulfurtransferase; COG: COG0607 Rhodanese-related sulfurtransferase; Psort location: endoplasmic reticulum, score: 9 YP_001455522.1 COG: COG2916 DNA-binding protein H-NS; Psort location: mitochondrial, score: 23 YP_001455523.1 Psort location: cytoplasmic, score: 23 YP_001455524.1 Psort location: mitochondrial, score: 23 YP_001455525.1 COG: NOG11269 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 23 YP_001455526.1 COG: NOG09772 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455527.1 COG: COG4575 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001455528.1 KEGG: eci:UTI89_C3030 1.7e-184 hypothetical protein K00375; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: cytoplasmic, score: 23 YP_001455529.1 KEGG: msm:MSMEG_6370 1.1e-20 pcaC; 4-carboxymuconolactone decarboxylase K01607; COG: COG2128 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001455530.1 KEGG: vfi:VFA1040 0.00063 glutaredoxin K00435; COG: COG0695 Glutaredoxin and related proteins; Psort location: cytoplasmic, score: 23 YP_001455531.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_001455532.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001455533.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_001455534.1 Psort location: nuclear, score: 23 YP_001455535.1 with ProWX is involved in the high-affinity uptake of glycine betaine YP_001455536.1 with ProVX is involved in the high-affinity uptake of glycine betaine YP_001455537.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine YP_001455538.1 KEGG: shn:Shewana3_1692 3.6e-15 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001455539.1 COG: COG1296 Predicted branched-chain amino acid permease (azaleucine resistance); Psort location: plasma membrane, score: 23 YP_001455540.1 KEGG: tws:TW336 0.0022 putative glycosyl transferase K02851; COG: NOG14220 non supervised orthologous group; Psort location: golgi, score: 9 YP_001455541.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB YP_001455542.1 COG: COG1566 Multidrug resistance efflux pump; Psort location: golgi, score: 9 YP_001455543.1 KEGG: sgl:SG1466 1.5e-06 deTHIobiotin synthase K01935; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001455544.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_001455545.1 involved in the first step of glutathione biosynthesis YP_001455546.1 KEGG: oih:OB2407 0.0064 alkaline phosphatase K01077; COG: COG1238 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001455547.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent YP_001455549.1 affects carbohydrate metabolism; has regulatory role in many processes YP_001455550.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001455551.1 COG: COG2137 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001455552.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001455553.1 COG: COG1546 Uncharacterized protein (competence- and mitomycin-induced); Psort location: cytoplasmic, score: 23 YP_001455554.1 COG: COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin; Psort location: extracellular, including cell wall, score: 9 YP_001455555.1 COG: COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; Psort location: plasma membrane, score: 23 YP_001455556.1 KEGG: rru:Rru_A3702 2.5e-39 ABC transporter component K06020; COG: COG1121 ABC-type Mn/Zn transport systems, ATPase component; Psort location: cytoplasmic, score: 23 YP_001455557.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan YP_001455558.1 KEGG: sec:SC2765 1.5e-96 srlA; PTS family, glucitol/sorbitol-specific enzyme IIC component,one of two IIC components K02782:K02783; COG: COG3730 Phosphotransferase system sorbitol-specific component IIC; Psort location: endoplasmic reticulum, score: 9 YP_001455559.1 KEGG: sec:SC2766 2.7e-161 srlE; PTS family, glucitol/sorbitol-specific IIB component, one of two IIC components K02782:K02783; COG: COG3732 Phosphotransferase system sorbitol-specific component IIBC; Psort location: endoplasmic reticulum, score: 9 YP_001455560.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001455561.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate YP_001455562.1 regulator for glucitol utilization YP_001455563.1 regulates genes involved in glucitol utilization YP_001455564.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate YP_001455565.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon YP_001455566.1 detoxifies nitric oxide using NADH YP_001455567.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase YP_001455568.1 Psort location: mitochondrial, score: 23 YP_001455569.1 KEGG: msu:MS0845 1.8e-06 acyP; acylphosphatases K01512; COG: COG0068 Hydrogenase maturation factor; Psort location: cytoplasmic, score: 23 YP_001455570.1 involved in electron transport from formate to hydrogen YP_001455571.1 KEGG: efa:EF1922 0.00024 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001455572.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001455573.1 KEGG: eci:UTI89_C3078 2.8e-246 ascB; 6-phospho-beta-glucosidase K01223; COG: COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase; Psort location: extracellular, including cell wall, score: 9 YP_001455574.1 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE YP_001455575.1 KEGG: eci:UTI89_C3081 2.6e-60 hycH; formate hydrogenlyase maturation protein HycH; COG: NOG09848 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455576.1 KEGG: eci:UTI89_C3082 1.6e-131 hycG; formate hydrogenlyase subunit 7; COG: COG3260 Ni,Fe-hydrogenase III small subunit; Psort location: cytoplasmic, score: 23 YP_001455577.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate YP_001455578.1 KEGG: eci:UTI89_C3084 0. hycE; formate hydrogenlyase subunit 5 precursor; COG: COG3261 Ni,Fe-hydrogenase III large subunit; Psort location: cytoplasmic, score: 23 YP_001455579.1 KEGG: eci:UTI89_C3085 8.3e-144 hycD; membrane-spanning protein of formate hydrogenase; COG: COG0650 Formate hydrogenlyase subunit 4; Psort location: plasma membrane, score: 23 YP_001455580.1 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3) YP_001455581.1 KEGG: eci:UTI89_C3087 2.3e-86 hycB; formate hydrogenlyase subunit 2; COG: COG1142 Fe-S-cluster-containing hydrogenase components 2; Psort location: nuclear, score: 23 YP_001455582.1 Psort location: nuclear, score: 23 YP_001455583.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon YP_001455584.1 plays a role in hydrogenase nickel cofactor insertion YP_001455585.1 GTP hydrolase involved in nickel liganding into hydrogenases YP_001455586.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase YP_001455587.1 COG: COG0409 Hydrogenase maturation factor; Psort location: cytoplasmic, score: 23 YP_001455588.1 KEGG: cch:Cag_0556 2.2e-79 hypE; hydrogenase expression/formation protein HypE K04655; COG: COG0309 Hydrogenase maturation factor; Psort location: cytoplasmic, score: 23 YP_001455589.1 KEGG: eci:UTI89_C3094 0. fhlA; formate hydrogenlyase transcriptional activator K01768; COG: COG3604 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains; Psort location: cytoplasmic, score: 23 YP_001455590.1 COG: COG2005 N-terminal domain of molybdenum-binding protein; Psort location: extracellular, including cell wall, score: 9 YP_001455591.1 COG: NOG16835 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001455592.1 COG: COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin; Psort location: mitochondrial, score: 23 YP_001455593.1 KEGG: rru:Rru_A2894 6.0e-86 ABC transporter component K02074; COG: COG1121 ABC-type Mn/Zn transport systems, ATPase component; Psort location: cytoplasmic, score: 23 YP_001455594.1 COG: COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; Psort location: plasma membrane, score: 23 YP_001455595.1 Psort location: nuclear, score: 23 YP_001455596.1 COG: COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001455597.1 This protein performs the mismatch recognition step during the DNA repair process YP_001455598.1 COG: NOG14130 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001455599.1 KEGG: gvi:gll3010 1.6e-53 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiD K03182; COG: COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases; Psort location: cytoplasmic, score: 23 YP_001455600.1 KEGG: sdy:SDY_2938 9.6e-95 phenylacrylic acid decarboxylase-like protein K03186; COG: COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase; Psort location: cytoplasmic, score: 23 YP_001455601.1 COG: COG1846 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001455602.1 Psort location: mitochondrial, score: 23 YP_001455603.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses YP_001455604.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus YP_001455605.1 Psort location: cytoplasmic, score: 23 YP_001455606.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins YP_001455607.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_001455608.1 catalyzes the modification of U13 in tRNA(Glu) YP_001455609.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_001455610.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_001455611.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein YP_001455612.1 KEGG: noc:Noc_1062 0.0027 adenylyl cyclase class-3/4/guanylyl cyclase K01768; COG: NOG12170 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001455613.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis YP_001455614.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ YP_001455615.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_001455616.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3 YP_001455617.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_001455618.1 Psort location: mitochondrial, score: 23 YP_001455619.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide YP_001455620.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity YP_001455621.1 Psort location: mitochondrial, score: 23 YP_001455622.1 KEGG: sec:SC2880 4.7e-63 ptpS; putative synthase K01737; COG: COG0720 6-pyruvoyl-tetrahydropterin synthase; Psort location: cytoplasmic, score: 23 YP_001455623.1 KEGG: ecj:JW2736 8.0e-178 ygcN; predicted oxidoreductase, FAD/NAD(P)-binding domain K00313; COG: COG0644 Dehydrogenases (flavoproteins); Psort location: cytoplasmic, score: 23 YP_001455624.1 KEGG: pde:Pden_0425 0.00026 electron-transferring-flavoprotein dehydrogenase K00311; COG: COG2440 Ferredoxin-like protein; Psort location: cytoplasmic, score: 23 YP_001455625.1 COG: COG1954 Glycerol-3-phosphate responsive antiterminator (mRNA-binding); Psort location: cytoplasmic, score: 23 YP_001455626.1 Psort location: nuclear, score: 23 YP_001455627.1 KEGG: fnu:FN1424 5.0e-08 acyl-CoA dehydrogenase, short-chain specific K00248; COG: COG2025 Electron transfer flavoprotein, alpha subunit; Psort location: cytoplasmic, score: 23 YP_001455628.1 COG: COG2086 Electron transfer flavoprotein, beta subunit; Psort location: cytoplasmic, score: 23 YP_001455629.1 KEGG: cal:orf19.3526 9.8e-14 ITR2; myo-inositol transporter K08140; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001455630.1 KEGG: eci:UTI89_C3136 4.2e-252 hypothetical protein K00803; COG: COG0277 FAD/FMN-containing dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001455631.1 Psort location: cytoplasmic, score: 23 YP_001455632.1 KEGG: ecs:ECs3630 2.2e-134 putative oxidoreductase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001455633.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001455634.1 KEGG: abo:ABO_1407 3.8e-52 sugar kinase, putative K00924; COG: COG1070 Sugar (pentulose and hexulose) kinases; Psort location: cytoplasmic, score: 23 YP_001455635.1 KEGG: hpa:HPAG1_0914 2.0e-05 hypothetical protein K04071; COG: COG0602 Organic radical activating enzymes; Psort location: cytoplasmic, score: 23 YP_001455636.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_001455637.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001455638.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_001455639.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP YP_001455640.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_001455641.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system YP_001455642.1 KEGG: stt:t2868 5.4e-172 glycerate kinase K00865; COG: COG1929 Glycerate kinase; Psort location: cytoplasmic, score: 23 YP_001455643.1 KEGG: sec:SC2900 1.2e-236 gudD; D-glucarate dehydratase K01706; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: vesicles of secretory system, score: 9 YP_001455644.1 KEGG: stm:STM2961 2.8e-239 ygcY; putative D-glucarate dehydratase K01706; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: cytoplasmic, score: 23 YP_001455645.1 KEGG: eci:UTI89_C0457 0.0016 ampG; AmpG muropeptide MFS transporter K08218; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001455646.1 Psort location: extracellular, including cell wall, score: 9 YP_001455647.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001455648.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp YP_001455649.1 KEGG: shn:Shewana3_2825 3.5e-10 dTDP-4-dehydrorhamnose 3,5-epimerase K01790; COG: COG3098 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001455650.1 putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function YP_001455651.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_001455652.1 KEGG: hch:HCH_00651 4.5e-129 predicted Rossmann fold nucleotide-binding protein K00052; COG: COG1611 Predicted Rossmann fold nucleotide-binding protein; Psort location: cytoplasmic, score: 23 YP_001455653.1 Psort location: nuclear, score: 23 YP_001455654.1 COG: COG0814 Amino acid permeases; Psort location: plasma membrane, score: 23 YP_001455655.1 KEGG: stm:STM2971 1.4e-235 sdaB; L-serine dehydratase (L-threonine deaminase 2) K01752; COG: COG1760 L-serine deaminase; Psort location: cytoplasmic, score: 23 YP_001455656.1 Psort location: mitochondrial, score: 23 YP_001455657.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups YP_001455658.1 KEGG: stm:STM2973 2.3e-187 fucO; L-1,2-propanediol oxidoreductase K00048; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: cytoplasmic, score: 23 YP_001455659.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate YP_001455660.1 Psort location: nuclear, score: 23 YP_001455661.1 COG: COG0738 Fucose permease; Psort location: plasma membrane, score: 23 YP_001455662.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose YP_001455663.1 Psort location: mitochondrial, score: 23 YP_001455664.1 Psort location: nuclear, score: 23 YP_001455665.1 KEGG: stm:STM2977 1.8e-228 fucK; L-fuculokinase K00879; COG: COG1070 Sugar (pentulose and hexulose) kinases; Psort location: cytoplasmic, score: 23 YP_001455666.1 COG: COG4154 Fucose dissimilation pathway protein FucU; Psort location: cytoplasmic, score: 23 YP_001455667.1 Psort location: cytoplasmic, score: 23 YP_001455668.1 Psort location: nuclear, score: 23 YP_001455669.1 regulates expression of genes involved in L-fucose utilization YP_001455670.1 KEGG: vfi:VF0593 1.1e-123 methyltransferase; COG: COG2933 Predicted SAM-dependent methyltransferase; Psort location: cytoplasmic, score: 23 YP_001455671.1 COG: COG2363 Uncharacterized small membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001455672.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence YP_001455673.1 COG: NOG14132 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001455674.1 KEGG: ssn:SSO_2967 3.1e-192 cysteine sulfinate desulfinase; COG: COG0520 Selenocysteine lyase; Psort location: cytoplasmic, score: 23 YP_001455675.1 KEGG: cps:CPS_2211 2.2e-15 putative selenocysteine lyase K02426; COG: COG2166 SufE protein probably involved in Fe-S center assembly; Psort location: cytoplasmic, score: 23 YP_001455676.1 KEGG: cal:orf19.2115 9.8e-25 molybdopterin-converting factor; COG: COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and THIamine biosynthesis family 1; Psort location: cytoplasmic, score: 23 YP_001455677.1 Psort location: nuclear, score: 23 YP_001455678.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_001455679.1 KEGG: ssn:SSO_2974 1.4e-210 putative amidase K01448; COG: COG0860 N-acetylmuramoyl-L-alanine amidase; Psort location: mitochondrial, score: 23 YP_001455680.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis YP_001455681.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity YP_001455682.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity YP_001455683.1 KEGG: sfx:S3029 0. ptr; protease III K01407; COG: COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like; Psort location: extracellular, including cell wall, score: 9 YP_001455684.1 Psort location: mitochondrial, score: 23 YP_001455685.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination YP_001455686.1 COG: COG4967 Tfp pilus assembly protein PilV; Psort location: nuclear, score: 23 YP_001455687.1 COG: NOG10274 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455688.1 COG: COG4795 Type II secretory pathway, component PulJ; Psort location: cytoplasmic, score: 23 YP_001455689.1 COG: COG2165 Type II secretory pathway, pseudopilin PulG; Psort location: cytoplasmic, score: 23 YP_001455691.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_001455692.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_001455696.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr YP_001455697.1 KEGG: eci:UTI89_C3232 2.2e-79 nudH, ygdP; (di)nucleoside polyphosphate hydrolase K08311; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: nuclear, score: 23 YP_001455698.1 Psort location: cytoplasmic, score: 23 YP_001455699.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair YP_001455700.1 COG: COG0861 Membrane protein TerC, possibly involved in tellurium resistance; Psort location: plasma membrane, score: 23 YP_001455701.1 Psort location: nuclear, score: 23 YP_001455702.1 COG: NOG13901 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455703.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH YP_001455704.1 KEGG: pca:Pcar_2776 8.2e-24 2-acyl-glycerophospho-ethanolamine acyltransferase K05939:K01909; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001455705.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1 YP_001455706.1 Psort location: cytoplasmic, score: 23 YP_001455707.1 controls transcription of galETKM YP_001455708.1 KEGG: efa:EF1922 2.1e-11 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001455709.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding YP_001455710.1 Psort location: cytoplasmic, score: 23 YP_001455711.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase YP_001455712.1 KEGG: eci:UTI89_C3244 1.8e-102 ygeA; hypothetical protein YgeA K01779; COG: COG1794 Aspartate racemase; Psort location: cytoplasmic, score: 23 YP_001455713.1 KEGG: nph:NP3568A 7.0e-05 homolog 3 to mannose-1-phosphate guanylyltransferase (GDP) K00971; COG: COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain; Psort location: cytoplasmic, score: 23 YP_001455714.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate YP_001455715.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate YP_001455716.1 Psort location: nuclear, score: 23 YP_001455717.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_001455718.1 KEGG: shn:Shewana3_3435 4.8e-05 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001455719.1 COG: COG4125 Predicted membrane protein; Psort location: mitochondrial, score: 23 YP_001455720.1 COG: COG0814 Amino acid permeases; Psort location: plasma membrane, score: 23 YP_001455721.1 Psort location: endoplasmic reticulum, score: 9 YP_001455722.1 COG: COG3710 DNA-binding winged-HTH domains; Psort location: nuclear, score: 23 YP_001455723.1 COG: NOG15336 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455724.1 COG: COG1937 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001455725.1 membrane protein conferring nickel and cobalt resistance YP_001455726.1 Psort location: nuclear, score: 23 YP_001455727.1 Psort location: nuclear, score: 23 YP_001455728.1 Psort location: mitochondrial, score: 23 YP_001455729.1 Psort location: nuclear, score: 23 YP_001455730.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001455731.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001455732.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001455733.1 COG: NOG07902 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455734.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: nuclear, score: 23 YP_001455735.1 KEGG: eci:UTI89_C4721 2.6e-37 yjdJ; hypothetical protein; COG: COG2388 Predicted acetyltransferase; Psort location: cytoplasmic, score: 23 YP_001455736.1 Psort location: cytoplasmic, score: 23 YP_001455737.1 COG: COG3592 Uncharacterized conserved protein; Psort location: cytoskeletal, score: 9 YP_001455738.1 COG: COG1620 L-lactate permease; Psort location: plasma membrane, score: 23 YP_001455739.1 Psort location: cytoplasmic, score: 23 YP_001455740.1 KEGG: eci:UTI89_C0329 1.6e-110 ykgE; hypothetical protein YkgE K00104; COG: COG0247 Fe-S oxidoreductase; Psort location: cytoplasmic, score: 23 YP_001455741.1 KEGG: eci:UTI89_C0330 6.3e-249 ykgF; putative electron transport protein YkgF K08263; COG: COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain; Psort location: cytoplasmic, score: 23 YP_001455742.1 COG: COG1556 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001455743.1 KEGG: eci:UTI89_C3250 1.7e-56 ygeR; hypothetical lipoprotein YgeR precursor; COG: COG0739 Membrane proteins related to metalloendopeptidases; Psort location: nuclear, score: 23 YP_001455744.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate YP_001455745.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_001455746.1 KEGG: reh:H16_A1169 3.5e-106 prfB; protein chain release factor B (RF-2); COG: COG1186 Protein chain release factor B; Psort location: cytoplasmic, score: 23 YP_001455747.1 Psort location: cytoplasmic, score: 23 YP_001455748.1 5'-3' single-stranded-DNA-specific exonuclease YP_001455749.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity YP_001455750.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001455751.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic YP_001455752.1 COG: NOG09016 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455753.1 COG: COG2938 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001455754.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator YP_001455755.1 Psort location: nuclear, score: 23 YP_001455756.1 COG: COG1272 Predicted membrane protein, hemolysin III homolog; Psort location: plasma membrane, score: 23 YP_001455757.1 COG: COG3097 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001455758.1 KEGG: bte:BTH_I1550 7.3e-08 glucokinase/transcriptional regulator, RpiR family, fusion K00845; COG: COG1737 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001455759.1 KEGG: sec:SC2992 1.7e-262 bglA; 6-phospho-beta-glucosidase A K01223; COG: COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase; Psort location: cytoplasmic, score: 23 YP_001455760.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_001455761.1 Psort location: mitochondrial, score: 23 YP_001455762.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_001455763.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_001455764.1 Psort location: nuclear, score: 23 YP_001455765.1 KEGG: ssn:SSO_3059 2.1e-193 visC; hypothetical protein; COG: COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases; Psort location: extracellular, including cell wall, score: 9 YP_001455766.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone YP_001455767.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide YP_001455768.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown YP_001455769.1 KEGG: shn:Shewana3_3505 5.2e-16 fructose-bisphosphatase K01086; COG: COG3027 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001455770.2 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function YP_001455771.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_001455772.1 Psort location: cytoplasmic, score: 23 YP_001455773.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_001455774.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_001455775.1 COG: COG2968 Uncharacterized conserved protein; Psort location: endoplasmic reticulum, score: 9 YP_001455776.1 Involved in the export of arginine YP_001455777.1 Psort location: nuclear, score: 23 YP_001455778.1 participates in the regulation of osmotic pressure changes within the cel YP_001455779.1 activator of the allDC-ylbA operon involved in allantoin utilization YP_001455780.1 COG: NOG06194 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001455781.1 Psort location: nuclear, score: 23 YP_001455782.1 COG: NOG06389 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455783.1 multicopy suppressor of dominant negative ftsH mutations YP_001455784.1 KEGG: dre:30298 4.8e-09 jak2b; Janus kinase 2b K04447; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001455785.1 Psort location: cytoplasmic, score: 23 YP_001455786.1 KEGG: ssn:SSO_0497 1.3e-92 arcC; putative carbamate kinase K00926; COG: COG0549 Carbamate kinase; Psort location: cytoplasmic, score: 23 YP_001455787.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_001455788.1 Psort location: nuclear, score: 23 YP_001455789.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_001455790.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate YP_001455791.1 KEGG: cya:CYA_1151 4.7e-24 glmU; UDP-N-acetylglucosamine pyrophosphorylase K04042:K00972; COG: COG1661 Predicted DNA-binding protein with PD1-like DNA-binding motif; Psort location: cytoplasmic, score: 23 YP_001455792.1 COG: NOG07916 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001455793.1 COG: COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters; Psort location: cytoplasmic, score: 23 YP_001455794.1 KEGG: syf:Synpcc7942_1406 2.2e-18 ATPase K02010; COG: COG1122 ABC-type cobalt transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001455795.1 KEGG: sme:SMb21276 8.1e-27 potA; putative spermidineputrescine ABC transporter ATP-binding protein K02052; COG: COG1118 ABC-type sulfate/molybdate transport systems, ATPase component; Psort location: cytoplasmic, score: 23 YP_001455796.1 KEGG: eci:UTI89_C3316 1.4e-86 yggC; hypothetical protein YggC K00867; COG: COG1072 Panthothenate kinase; Psort location: cytoplasmic, score: 23 YP_001455797.1 COG: COG3722 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001455798.1 KEGG: ypn:YPN_3759 7.8e-93 hypothetical protein K02446; COG: COG1494 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins; Psort location: cytoplasmic, score: 23 YP_001455799.1 KEGG: vfi:VFA0062 2.9e-150 L-sorbose 1-phosphate reductase K00100; COG: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001455800.1 KEGG: eco:b2933 7.1e-218 cmtA, G527, cmt, tolM; PTS family enzyme IICB, mannitol-specific, cryptic K02799:K02800; COG: COG2213 Phosphotransferase system, mannitol-specific IIBC component; Psort location: endoplasmic reticulum, score: 9 YP_001455801.1 TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein YP_001455802.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001455803.1 Psort location: mitochondrial, score: 23 YP_001455804.1 KEGG: ecs:ECs3811 9.8e-102 putative metalloprotease K07387; COG: COG0501 Zn-dependent protease with chaperone function; Psort location: nuclear, score: 23 YP_001455805.1 Psort location: nuclear, score: 23 YP_001455806.1 KEGG: psp:PSPPH_3782 1.0e-60 porin D; COG: NOG08591 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455807.1 catalyzes the formation of putrescine from agmatine YP_001455808.1 Psort location: nuclear, score: 23 YP_001455809.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis YP_001455810.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001455811.1 KEGG: cal:orf19.3526 2.0e-53 ITR2; myo-inositol transporter K08140; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001455812.1 COG: COG3091 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001455813.1 KEGG: eco:b2945 8.5e-119 endA; DNA-specific endonuclease I K01150; COG: COG2356 Endonuclease I; Psort location: extracellular, including cell wall, score: 9 YP_001455814.2 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001455815.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_001455816.1 COG: COG1678 Putative transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001455817.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_001455818.1 Psort location: mitochondrial, score: 23 YP_001455819.1 KEGG: pen:PSEEN2333 2.8e-28 xcpR-2; type II secretion pathway protein E K01509; COG: COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT; Psort location: cytoplasmic, score: 23 YP_001455820.1 KEGG: eci:UTI89_C3340 6.5e-105 yggS; hypothetical protein; COG: COG0325 Predicted enzyme with a TIM-barrel fold; Psort location: cytoplasmic, score: 23 YP_001455821.1 COG: COG0762 Predicted integral membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001455822.1 COG: COG1872 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001455823.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_001455824.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001455825.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis YP_001455826.1 COG: NOG06291 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455827.1 COG: COG3171 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001455828.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_001455829.1 KEGG: eci:UTI89_C3351 2.6e-181 mutY; A/G-specific adenine glycosylase K03575; COG: COG1194 A/G-specific DNA glycosylase; Psort location: cytoplasmic, score: 23 YP_001455830.1 COG: COG2924 Fe-S cluster protector protein; Psort location: extracellular, including cell wall, score: 9 YP_001455831.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_001455832.1 KEGG: eci:UTI89_C3355 3.6e-207 nupG; transport of nucleosides, permease protein K03289; COG: NOG06211 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001455833.1 KEGG: stm:STM3114 0. speC; orniTHIne decarboxylase isozyme K01581; COG: COG1982 Arginine/lysine/orniTHIne decarboxylases; Psort location: cytoplasmic, score: 23 YP_001455834.1 Psort location: cytoplasmic, score: 23 YP_001455835.1 COG: COG1811 Uncharacterized membrane protein, possible Na+ channel or pump; Psort location: plasma membrane, score: 23 YP_001455836.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: mitochondrial, score: 23 YP_001455837.1 Psort location: cytoplasmic, score: 23 YP_001455838.1 COG: NOG06299 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001455839.1 COG: COG3311 Predicted transcriptional regulator; Psort location: mitochondrial, score: 23 YP_001455840.1 COG: NOG36967 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455841.1 Psort location: mitochondrial, score: 23 YP_001455842.1 Psort location: nuclear, score: 23 YP_001455843.1 Psort location: cytoplasmic, score: 23 YP_001455844.1 Psort location: cytoplasmic, score: 23 YP_001455845.1 Psort location: endoplasmic reticulum, score: 9 YP_001455846.1 Psort location: endoplasmic reticulum, score: 9 YP_001455847.1 Psort location: cytoplasmic, score: 23 YP_001455848.1 COG: COG3456 Uncharacterized conserved protein, contains FHA domain; Psort location: cytoplasmic, score: 23 YP_001455849.1 COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: cytoplasmic, score: 23 YP_001455850.1 Psort location: endoplasmic reticulum, score: 9 YP_001455851.1 Psort location: endoplasmic reticulum, score: 9 YP_001455852.1 Psort location: endoplasmic reticulum, score: 9 YP_001455853.1 COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001455854.1 COG: COG5351 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001455855.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: mitochondrial, score: 23 YP_001455856.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: cytoplasmic, score: 23 YP_001455857.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001455858.1 Psort location: cytoplasmic, score: 23 YP_001455859.1 response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance YP_001455860.1 KEGG: sbo:SBO_2396 2.5e-190 evgS, evgA; putative sensor for regulator EvgA K07679; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: endoplasmic reticulum, score: 9 YP_001455861.1 Psort location: cytoplasmic, score: 23 YP_001455862.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001455863.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: nuclear, score: 23 YP_001455864.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001455865.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: mitochondrial, score: 23 YP_001455866.1 KEGG: eci:UTI89_C3737 3.1e-11 yhdM; Zn(II)-responsive regulator of ZntA; COG: COG0789 Predicted transcriptional regulators; Psort location: nuclear, score: 23 YP_001455867.1 KEGG: bur:Bcep18194_C7479 2.5e-128 alpha/beta hydrolase K00433; COG: COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Psort location: cytoplasmic, score: 23 YP_001455868.1 KEGG: bcz:BCZK2914 4.9e-06 adaA; methylphosphotriester-DNA alkyltransferase K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001455869.1 KEGG: pfl:PFL_2420 1.3e-131 D-isomer specific 2-hydroxyacid dehydrogenase family protein K00002; COG: COG1064 Zn-dependent alcohol dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001455870.1 Psort location: extracellular, including cell wall, score: 9 YP_001455871.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction YP_001455872.1 KEGG: eci:UTI89_C1715 3.3e-236 ydeP; hypothetical protein YdeP K00122; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001455873.1 YghU; B2989; one of eight putative glutathione transferase proteins from E. coli YP_001455874.1 COG: COG0725 ABC-type molybdate transport system, periplasmic component; Psort location: cytoplasmic, score: 23 YP_001455875.1 COG: COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001455876.1 COG: COG0298 Hydrogenase maturation factor; Psort location: endoplasmic reticulum, score: 9 YP_001455877.1 plays a role in hydrogenase nickel cofactor insertion YP_001455878.1 COG: NOG08099 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455879.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC) YP_001455880.1 involved in hydrogen uptake YP_001455881.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits YP_001455882.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2 YP_001455883.1 involved in hydrogen uptake YP_001455884.1 COG: NOG11338 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455885.1 KEGG: ana:alr1121 0.00022 two-component hybrid sensor and regulator; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001455886.1 Psort location: cytoplasmic, score: 23 YP_001455887.1 KEGG: eci:UTI89_C3421 1.5e-153 putative enzyme K01061; COG: COG0412 Dienelactone hydrolase and related enzymes; Psort location: mitochondrial, score: 23 YP_001455888.1 KEGG: eci:UTI89_C3422 1.0e-168 yghZ; hypothetical protein YghZ; COG: COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases); Psort location: nuclear, score: 23 YP_001455889.1 Psort location: endoplasmic reticulum, score: 9 YP_001455890.1 COG: NOG27696 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455891.1 COG: NOG30084 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001455892.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_001455893.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_001455894.1 catalyzes the formation of L-homocysteine from cystathionine YP_001455895.1 KEGG: lsl:LSL_1322 1.7e-06 alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: endoplasmic reticulum, score: 9 YP_001455896.1 KEGG: bcz:BCZK3497 4.8e-07 adaA; transcriptional regulator, AraC family K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001455897.1 Psort location: cytoplasmic, score: 23 YP_001455898.1 KEGG: sec:SC3108 2.6e-188 yqhD; putative alcohol dehydrogenase K08325; COG: COG1979 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family; Psort location: cytoplasmic, score: 23 YP_001455899.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate YP_001455900.1 KEGG: reh:H16_A0281 3.0e-13 diadenosine tetraphosphate (Ap4A) hydrolase K01518; COG: COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases; Psort location: cytoplasmic, score: 23 YP_001455901.1 KEGG: eci:UTI89_C3435 0. hypothetical protein; COG: COG1032 Fe-S oxidoreductase; Psort location: nuclear, score: 23 YP_001455902.1 KEGG: eci:UTI89_C3443 5.1e-247 sufI; FtsI suppressor K04753; COG: COG2132 Putative multicopper oxidases; Psort location: extracellular, including cell wall, score: 9 YP_001455903.1 KEGG: sty:STY3350 2.1e-124 plsC; 1-acyl-glycerol-3-phosphate acyltransferase K00655; COG: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; Psort location: endoplasmic reticulum, score: 9 YP_001455904.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001455905.1 COG: COG3111 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001455906.1 response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes YP_001455907.1 KEGG: stm:STM3178 3.2e-199 ygiY; putative sensory histidine kinase in regulatory system K07645; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001455908.1 KEGG: eci:UTI89_C3455 4.5e-97 mdaB; modulator of drug activity B K03923; COG: COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); Psort location: cytoplasmic, score: 23 YP_001455909.1 COG: COG1359 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001455910.1 KEGG: sgl:SG2119 1.3e-124 putative glucuronyl hydrolase K01238; COG: NOG09941 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455911.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001455912.1 COG: COG4289 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001455913.1 KEGG: bcz:BCZK3497 6.4e-12 adaA; transcriptional regulator, AraC family K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001455914.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001455915.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate YP_001455916.1 KEGG: eci:UTI89_C3466 1.0e-136 icc; icc protein K03651; COG: COG1409 Predicted phosphohydrolases; Psort location: cytoplasmic, score: 23 YP_001455917.1 COG: COG3151 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001455918.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_001455919.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell YP_001455920.1 Psort location: cytoplasmic, score: 23 YP_001455921.1 COG: COG5463 Predicted integral membrane protein; Psort location: nuclear, score: 23 YP_001455922.1 KEGG: vvy:VV2267 1.8e-123 glutaTHIonylspermidine synthase K01917; COG: COG0754 GlutaTHIonylspermidine synthase; Psort location: cytoplasmic, score: 23 YP_001455923.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine YP_001455924.1 COG: COG0428 Predicted divalent heavy-metal cations transporter; Psort location: endoplasmic reticulum, score: 9 YP_001455925.1 Psort location: cytoplasmic, score: 23 YP_001455926.1 DHBP synthase; functions during riboflavin biosynthesis YP_001455927.1 COG: COG2960 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001455928.1 Involved in glycogen synthesis. May be involved in glycogen priming YP_001455929.1 Psort location: mitochondrial, score: 23 YP_001455930.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose YP_001455931.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_001455932.1 Psort location: mitochondrial, score: 23 YP_001455933.1 Psort location: mitochondrial, score: 23 YP_001455934.1 KEGG: aha:AHA_3770 5.9e-40 adenylate cyclase K01768; COG: COG3025 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001455935.1 COG: COG3103 SH3 domain protein; Psort location: extracellular, including cell wall, score: 23 YP_001455936.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases YP_001455937.1 Psort location: nuclear, score: 23 YP_001455938.1 Psort location: cytoplasmic, score: 23 YP_001455939.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_001455940.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin YP_001455941.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_001455942.1 activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol YP_001455943.1 Involved in the tartrate degradation pathway YP_001455944.1 Involved in the tartrate degradation pathway YP_001455945.1 COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001455946.1 KEGG: hpa:HPAG1_0068 2.6e-07 urease accessory protein UreH K01427; COG: COG0829 Urease accessory protein UreH; Psort location: cytoplasmic, score: 23 YP_001455947.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter YP_001455948.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active YP_001455949.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits YP_001455950.1 involved in the assembly of the urease metallocenter; possible nickel donor YP_001455951.1 KEGG: cgl:NCgl0087 2.7e-12 cgl0088; urease accessory protein UreF K03188; COG: COG0830 Urease accessory protein UreF; Psort location: mitochondrial, score: 23 YP_001455952.1 KEGG: reh:H16_A1087 6.3e-75 ureG; UreA amidohydrolase (urease) regulatory and maturation protein UreG; COG: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; Psort location: cytoplasmic, score: 23 YP_001455953.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001455954.1 Psort location: mitochondrial, score: 23 YP_001455955.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_001455956.1 Psort location: cytoplasmic, score: 23 YP_001455957.1 synthesizes RNA primers at the replication forks YP_001455958.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_001455959.1 KEGG: ssn:SSO_3206 3.1e-73 ygjF; hypothetical protein K03649; COG: COG3663 G:T/U mismatch-specific DNA glycosylase; Psort location: cytoplasmic, score: 23 YP_001455960.1 COG: NOG09762 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455961.1 Psort location: mitochondrial, score: 23 YP_001455962.1 Psort location: nuclear, score: 23 YP_001455963.1 Positively regulates the dhaKLM operon from a sigma-70 promoter YP_001455964.1 KEGG: plu:plu4115 6.9e-117 gldA; glycerol dehydrogenase (GLDH) K00005; COG: COG0371 Glycerol dehydrogenase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001455965.1 Psort location: mitochondrial, score: 23 YP_001455966.1 Psort location: cytoplasmic, score: 23 YP_001455967.1 Psort location: cytoplasmic, score: 23 YP_001455968.1 Psort location: mitochondrial, score: 23 YP_001455969.1 Psort location: cytoplasmic, score: 23 YP_001455970.1 KEGG: rle:RL2900 2.7e-129 dhaK; putative dihydroxyacetone kinase K00863; COG: COG2376 Dihydroxyacetone kinase; Psort location: cytoplasmic, score: 23 YP_001455971.1 COG: COG2375 Siderophore-interacting protein; Psort location: cytoplasmic, score: 23 YP_001455972.1 Psort location: endoplasmic reticulum, score: 9 YP_001455973.1 Psort location: extracellular, including cell wall, score: 9 YP_001455974.1 COG: COG1695 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001455975.1 KEGG: pae:PA5484 1.2e-08 probable two-component sensor K02484; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001455976.1 KEGG: azo:azo3685 6.1e-13 putative hybrid sensor and regulator protein; COG: COG2202 FOG: PAS/PAC domain; Psort location: endoplasmic reticulum, score: 9 YP_001455977.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate YP_001455978.1 KEGG: stm:STM3219 0. fadH; 2,4-dieonyl-CoA reductase K00219; COG: COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001455979.1 KEGG: ecs:ECs3966 8.3e-192 putative ribosomal RNA small subunit methyltransferase D K00564; COG: COG2813 16S RNA G1207 methylase RsmC; Psort location: cytoplasmic, score: 23 YP_001455980.1 COG: COG1451 Predicted metal-dependent hydrolase; Psort location: cytoplasmic, score: 23 YP_001455981.1 KEGG: ecp:ECP_3178 1.1e-148 hypothetical oxidoreductase YgjR; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001455982.1 COG: COG0861 Membrane protein TerC, possibly involved in tellurium resistance; Psort location: plasma membrane, score: 23 YP_001455983.1 involved in the import of serine and threonine coupled with the import of sodium YP_001455984.1 KEGG: ecp:ECP_3182 4.9e-249 altronate hydrolase K01685; COG: COG2721 Altronate dehydratase; Psort location: cytoplasmic, score: 23 YP_001455985.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism YP_001455986.1 KEGG: fal:FRAAL6577 0.0031 hppA; pyrophosphate-energized proton pump (pyrophosphate-energized inorganic pyrophosphatase) (H+-PPase) (membrane-bound proton-translocating pyrophosphatase) K01507; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001455987.1 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization. YP_001455988.1 KEGG: sab:SAB2386 7.4e-10 probable alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: endoplasmic reticulum, score: 9 YP_001455989.1 COG: NOG09774 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455990.1 KEGG: mja:MJ1454 0.00013 aroD; 3-dehydroquinate dehydratase K03785; COG: NOG17164 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001455991.1 KEGG: tma:TM1614 0.0016 ATP synthase F0, subunit b K02109; COG: COG4575 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001455992.1 COG: COG5393 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001455993.1 COG: NOG11454 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001455994.1 KEGG: lpn:lpg0671 0.0020 ndh; NADH dehydrogenase transmembrane protein K03885; COG: COG2259 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001455995.1 KEGG: eci:UTI89_C3540 2.6e-172 yqjG; putative transferase K07393; COG: COG0435 Predicted glutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001455996.1 COG: COG3152 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001455997.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001455998.1 COG: COG1741 Pirin-related protein; Psort location: cytoplasmic, score: 23 YP_001455999.1 COG: NOG18539 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456000.1 KEGG: stm:STM4281 2.5e-05 nrfE; putative methylase K04016; Psort location: nuclear, score: 23 YP_001456001.1 COG: COG3681 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001456002.1 COG: COG0814 Amino acid permeases; Psort location: plasma membrane, score: 23 YP_001456003.1 KEGG: spt:SPA3109 1.8e-221 tdcG; L-serine dehydratase K01752; COG: COG1760 L-serine deaminase; Psort location: cytoplasmic, score: 23 YP_001456004.1 KEGG: ape:APE_1501.1 9.6e-24 ribonuclease UK114; COG: COG0251 Putative translation initiation inhibitor, yjgF family; Psort location: cytoplasmic, score: 23 YP_001456005.1 KEGG: stm:STM3241 0. tdcE; pyruvate formate-lyase 4/2-ketobutyrate formate-lyase K00656; COG: COG1882 Pyruvate-formate lyase; Psort location: cytoplasmic, score: 23 YP_001456006.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism YP_001456007.1 involved in the import of threonine and serine in combination with the import of a proton YP_001456008.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic YP_001456009.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation YP_001456010.1 Psort location: mitochondrial, score: 23 YP_001456011.1 KEGG: sfx:S3376 1.1e-171 yhaD; glycerate kinase K00865; COG: COG1929 Glycerate kinase; Psort location: cytoplasmic, score: 23 YP_001456012.1 catalyzes the reduction of tartronate semialdehyde to glycerate YP_001456013.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate YP_001456014.1 Psort location: nuclear, score: 23 YP_001456015.1 Psort location: mitochondrial, score: 23 YP_001456016.1 Psort location: nuclear, score: 23 YP_001456017.1 Psort location: cytoplasmic, score: 23 YP_001456018.1 KEGG: stm:STM3250 3.6e-269 garD; galactarate dehydrogenase K01708; COG: COG2721 Altronate dehydratase; Psort location: cytoplasmic, score: 23 YP_001456019.1 transcriptional repressor for the agaZVWA and agaSYBCDI operons YP_001456020.1 KEGG: eci:UTI89_C3561 3.8e-203 agaZ; putative tagatose 6-phosphate kinase 2 K00917; COG: COG4573 Predicted tagatose 6-phosphate kinase; Psort location: cytoplasmic, score: 23 YP_001456021.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport YP_001456022.1 KEGG: eci:UTI89_C3570 4.3e-44 agaC; PTS system, N-acetylgalactosamine-specific IIC component 1 K02746; COG: COG3715 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC; Psort location: plasma membrane, score: 23 YP_001456023.1 KEGG: eci:UTI89_C3571 1.7e-56 agaD; PTS system, N-acetylgalactosamine-specific IID component K02747; COG: COG3716 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID; Psort location: plasma membrane, score: 23 YP_001456024.1 KEGG: ecs:ECs4014 9.0e-60 N-acetyl-galactosamine / galactosamine PTS system enzyme IIA component K02744; COG: COG2893 Phosphotransferase system, mannose/fructose-specific component IIA; Psort location: cytoplasmic, score: 23 YP_001456025.1 KEGG: ecp:ECP_3227 7.3e-168 putative N-acetylgalctosamine-6-phosphate deacetylase K02079; COG: COG1820 N-acetylglucosamine-6-phosphate deacetylase; Psort location: cytoplasmic, score: 23 YP_001456026.1 KEGG: ecp:ECP_3228 4.6e-175 putative tagatose-6-phosphate ketose/aldose isomerase K02082; COG: COG2222 Predicted phosphosugar isomerases; Psort location: cytoplasmic, score: 23 YP_001456027.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway YP_001456028.1 KEGG: efa:EF0028 6.1e-164 PTS system, IIBC components K02790:K02791; COG: COG1264 Phosphotransferase system IIB components; Psort location: plasma membrane, score: 23 YP_001456029.1 KEGG: ecc:c1175 1.0e-184 putative aminotransferase K00842; COG: COG1168 Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities; Psort location: cytoplasmic, score: 23 YP_001456030.1 KEGG: eci:UTI89_C3573 1.2e-142 yraL; hypothetical protein; COG: COG0313 Predicted methyltransferases; Psort location: cytoplasmic, score: 23 YP_001456031.1 KEGG: bpe:BP0475 0.00014 rne, ams, hmp1; ribonuclease E K08300; COG: COG3107 Putative lipoprotein; Psort location: nuclear, score: 23 YP_001456032.1 KEGG: eci:UTI89_C3574 2.8e-49 yraN; hypothetical protein YraN K07460; COG: COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase; Psort location: cytoplasmic, score: 23 YP_001456033.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein YP_001456034.1 COG: COG2823 Predicted periplasmic or secreted lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001456035.1 COG: COG0701 Predicted permeases; Psort location: plasma membrane, score: 23 YP_001456036.1 Psort location: nuclear, score: 23 YP_001456037.1 KEGG: hal:VNG1932G 2.8e-09 nolA; NADH dehydrogenase/oxidoreductase-like protein K00329:K00356; COG: COG0702 Predicted nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001456038.1 COG: COG3787 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001456039.1 KEGG: mca:MCA0838 0.0029 type I restriction-modification system, R subunit K01153; COG: COG2827 Predicted endonuclease containing a URI domain; Psort location: cytoplasmic, score: 23 YP_001456040.1 KEGG: sec:SC3213 7.7e-86 yhbS; putative ABC superfamily (membrane) transport protein K03824; COG: COG3153 Predicted acetyltransferase; Psort location: cytoplasmic, score: 23 YP_001456041.1 Psort location: mitochondrial, score: 23 YP_001456042.1 KEGG: bta:508918 0.00045 SCP2; sterol carrier protein 2 K08764; COG: COG3154 Putative lipid carrier protein; Psort location: cytoplasmic, score: 23 YP_001456043.1 KEGG: ecp:ECP_3246 5.8e-175 putative protease YhbU precursor K08303; COG: COG0826 Collagenase and related proteases; Psort location: cytoplasmic, score: 23 YP_001456044.1 KEGG: eci:UTI89_C3586 4.7e-150 yhbV; hypothetical protein YhbV K01423; COG: COG0826 Collagenase and related proteases; Psort location: cytoplasmic, score: 23 YP_001456045.1 Psort location: cytoplasmic, score: 23 YP_001456046.1 Psort location: mitochondrial, score: 23 YP_001456047.1 KEGG: eci:UTI89_C3587 1.6e-172 yhbW; hypothetical protein K00494; COG: COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001456048.1 tryptophan transporter of high affinity YP_001456049.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division YP_001456050.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing YP_001456051.1 Psort location: mitochondrial, score: 23 YP_001456052.1 KEGG: eci:UTI89_C3594 0. pnp; polyribonucleotide nucleotidyltransferase K00962; COG: COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase); Psort location: mitochondrial, score: 23 YP_001456053.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_001456054.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_001456055.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_001456056.1 Psort location: cytoplasmic, score: 23 YP_001456057.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001456058.1 COG: NOG29605 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456059.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001456060.2 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_001456061.1 Psort location: nuclear, score: 23 YP_001456062.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis YP_001456063.1 KEGG: lpn:lpg1509 0.0046 D-alanyl-D-alanine carboxypeptidase K07258; COG: COG1314 Preprotein translocase subunit SecG; Psort location: endoplasmic reticulum, score: 9 YP_001456064.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_001456065.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate YP_001456066.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins YP_001456067.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit YP_001456068.1 RNA binding protein found associated to pre-50S subunit of the ribosome; putative role in ribosome assembly; necessary for optimal growth but not cell viability YP_001456069.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001456070.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_001456071.1 Psort location: cytoplasmic, score: 23 YP_001456072.1 Psort location: nuclear, score: 23 YP_001456073.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001456074.1 Psort location: nuclear, score: 23 YP_001456075.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001456076.1 involved in the peptidyltransferase reaction during translation YP_001456077.1 KEGG: sec:SC3243 7.1e-186 ispB; octaprenyl diphosphate synthase K02523; COG: COG0142 Geranylgeranyl pyrophosphate synthase; Psort location: cytoplasmic, score: 23 YP_001456078.1 activator of maltose metabolism genes YP_001456079.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001456080.1 COG: COG5007 Predicted transcriptional regulator, BolA superfamily; Psort location: cytoplasmic, score: 23 YP_001456081.1 KEGG: reu:Reut_A3046 0.00056 hemK; modification methylase HemK K02493; COG: COG3113 Predicted NTP binding protein (contains STAS domain); Psort location: cytoplasmic, score: 23 YP_001456082.1 COG: COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component; Psort location: extracellular, including cell wall, score: 9 YP_001456083.1 COG: COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component; Psort location: endoplasmic reticulum, score: 9 YP_001456084.1 COG: COG0767 ABC-type transport system involved in resistance to organic solvents, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001456085.1 ATP-binding subunit of a putative ABC toluene efflux transporter YP_001456086.1 YrbG; inner membrane protein involved in cell envelope integrity; putative sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers YP_001456087.1 KEGG: stm:STM3315 3.0e-162 yrbH; putative sugar phosphate isomerase K06041; COG: COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Psort location: cytoplasmic, score: 23 YP_001456088.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis YP_001456089.1 COG: COG3117 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001456090.1 LptA; periplasmic binding protein part of a putative ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system YP_001456091.1 KEGG: pen:PSEEN1094 1.0e-83 ABC transporter, ATP-binding protein; COG: COG1137 ABC-type (unclassified) transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001456092.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_001456093.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing YP_001456094.1 KEGG: sbo:SBO_3178 1.6e-78 ptsN; phosphotransferase system enzyme IIA K02806; COG: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); Psort location: cytoplasmic, score: 23 YP_001456095.1 KEGG: reh:H16_A0381 1.5e-59 predicted P-loop-containing kinase K01009; COG: COG1660 Predicted P-loop-containing kinase; Psort location: cytoplasmic, score: 23 YP_001456096.1 KEGG: aha:AHA_3919 9.7e-31 multiphosphoryl transfer protein (MTP) K00924; COG: COG1925 Phosphotransferase system, HPr-related proteins; Psort location: cytoplasmic, score: 23 YP_001456097.1 KEGG: ava:Ava_0219 0.0082 serine/threonine protein kinase K00908; COG: NOG06212 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001456098.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan YP_001456099.1 COG: COG3155 Uncharacterized protein involved in an early stage of isoprenoid biosynthesis; Psort location: extracellular, including cell wall, score: 9 YP_001456100.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA YP_001456101.1 Psort location: cytoplasmic, score: 23 YP_001456102.1 KEGG: eci:UTI89_C3647 7.0e-60 yhcC; hypothetical protein; COG: COG1242 Predicted Fe-S oxidoreductase; Psort location: cytoplasmic, score: 23 YP_001456103.1 Psort location: cytoplasmic, score: 23 YP_001456104.1 Psort location: cytoplasmic, score: 23 YP_001456105.1 Psort location: nuclear, score: 23 YP_001456106.1 Psort location: cytoplasmic, score: 23 YP_001456107.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate YP_001456108.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_001456109.1 COG: COG4804 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001456110.1 COG: COG2731 Beta-galactosidase, beta subunit; Psort location: cytoplasmic, score: 23 YP_001456111.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein YP_001456112.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_001456113.1 KEGG: cal:orf19.6141 1.6e-05 HXT1; high-affinity hexose (glucose) transporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001456114.1 Psort location: mitochondrial, score: 23 YP_001456115.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid YP_001456116.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization YP_001456117.1 COG: COG2969 Stringent starvation protein B; Psort location: cytoplasmic, score: 23 YP_001456118.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation YP_001456119.1 forms a direct contact with the tRNA during translation YP_001456120.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001456121.1 Psort location: nuclear, score: 23 YP_001456122.1 KEGG: reh:H16_A2322 3.6e-72 ATPase K01529; COG: COG1485 Predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001456123.1 KEGG: eco:b3233 1.1e-63 yhcB; hypothetical protein K00424; COG: COG3105 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001456124.1 Psort location: mitochondrial, score: 23 YP_001456125.1 KEGG: spt:SPA3215 2.5e-215 degQ; serine protease K04772; COG: COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; Psort location: extracellular, including cell wall, score: 9 YP_001456126.1 KEGG: sec:SC3287 3.7e-173 degS; periplasmic serine endoprotease K04691; COG: COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; Psort location: endoplasmic reticulum, score: 9 YP_001456127.1 oxidizes malate to oxaloacetate YP_001456128.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_001456129.1 Psort location: nuclear, score: 23 YP_001456130.1 COG: NOG12178 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001456131.1 COG: COG2732 Barstar, RNAse (barnase) inhibitor; Psort location: cytoplasmic, score: 23 YP_001456132.1 KEGG: eca:ECA0280 2.4e-201 succinate-semialdehyde dehydrogenase [NADP+] K00135; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001456133.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate YP_001456134.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate YP_001456135.1 membrane protein AaeX; the gene is a member of the aaeXAB operon YP_001456136.1 Psort location: mitochondrial, score: 23 YP_001456137.1 KEGG: shn:Shewana3_3435 8.8e-10 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001456138.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA YP_001456139.1 Psort location: mitochondrial, score: 23 YP_001456140.1 COG: COG3164 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001456141.1 involved in the processing of the 5'end of 16S rRNA YP_001456142.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_001456143.1 part of cell wall structural complex MreBCD; transmembrane component YP_001456144.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_001456145.1 functions in MreBCD complex in some organisms YP_001456146.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules YP_001456147.1 KEGG: eci:UTI89_C3684 8.6e-158 yhdH; protein YhdH K00001; COG: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases; Psort location: endoplasmic reticulum, score: 9 YP_001456148.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_001456149.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme YP_001456150.1 Psort location: cytoplasmic, score: 23 YP_001456151.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_001456152.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001456153.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001456154.1 COG: COG3924 Predicted membrane protein; Psort location: mitochondrial, score: 23 YP_001456155.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase YP_001456156.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_001456157.1 KEGG: eca:ECA0257 1.1e-54 cah; carbonic anhydrase K01674; COG: COG3338 Carbonic anhydrase; Psort location: nuclear, score: 23 YP_001456158.1 KEGG: sec:SC3322 6.6e-167 yhdG, nifR3; putative TIM-barrel enzyme, possibly dehydrogenase K05540; COG: COG0042 tRNA-dihydrouridine synthase; Psort location: cytoplasmic, score: 23 YP_001456159.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription YP_001456160.1 KEGG: sec:SC3324 3.2e-135 yhdJ; putative methyltransferase K07319; COG: COG0863 DNA modification methylase; Psort location: cytoplasmic, score: 23 YP_001456161.1 COG: NOG13902 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001456162.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001456163.1 COG: COG0845 Membrane-fusion protein; Psort location: endoplasmic reticulum, score: 9 YP_001456164.1 KEGG: eci:UTI89_C2351 4.9e-107 yegO; hypothetical protein YegO K07789; COG: COG0841 Cation/multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001456165.1 COG: NOG14133 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456166.1 Psort location: mitochondrial, score: 23 YP_001456167.1 KEGG: bur:Bcep18194_A4762 1.8e-16 ABC amino acid transporter, periplasmic ligand binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001456168.1 KEGG: eca:ECA0855 1.4e-19 ABC transporter permease protein K02028; COG: COG4597 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001456169.1 KEGG: sma:SAV6546 1.1e-22 putative ABC transporter permease K02028; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: plasma membrane, score: 23 YP_001456170.1 KEGG: ecs:ECs4144 2.1e-129 putative ATP-binding component of a transport system K02028; COG: COG1126 ABC-type polar amino acid transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001456172.1 Psort location: nuclear, score: 23 YP_001456173.1 KEGG: eci:UTI89_C3724 8.3e-89 yrdA; protein YrdA K00680; COG: COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily; Psort location: cytoplasmic, score: 23 YP_001456174.1 COG: NOG13911 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456175.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_001456176.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA YP_001456177.1 KEGG: cvi:CV4269 3.9e-44 topA; DNA topoisomerase K03168; COG: COG0551 Zn-finger domain associated with topoisomerase type I; Psort location: nuclear, score: 23 YP_001456178.1 COG: COG2922 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001456179.1 COG: COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake; Psort location: cytoplasmic, score: 23 YP_001456180.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001456181.1 KEGG: sec:SC3343 2.7e-129 fmt; 10-formyltetrahydrofolate:L-meTHIonyl-tRNA(fMet) N-formyltransferase K00604; COG: COG0223 MeTHIonyl-tRNA formyltransferase; Psort location: cytoplasmic, score: 23 YP_001456182.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase YP_001456183.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_001456184.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_001456185.1 COG: COG3036 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001456186.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators YP_001456187.1 COG: NOG18395 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001456188.1 COG: COG0203 Ribosomal protein L17; Psort location: cytoplasmic, score: 23 YP_001456189.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001456190.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001456192.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_001456193.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001456194.1 late assembly protein YP_001456195.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001456197.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001456198.1 binds 5S rRNA along with protein L5 and L25 YP_001456201.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001456202.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_001456203.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001456204.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001456205.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_001456206.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_001456207.1 one of the stabilizing components for the large ribosomal subunit YP_001456208.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001456209.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_001456211.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001456212.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001456213.1 Psort location: cytoplasmic, score: 23 YP_001456214.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001456215.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001456217.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001456218.1 Psort location: extracellular, including cell wall, score: 9 YP_001456219.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001456220.1 COG: COG0051 Ribosomal protein S10; Psort location: cytoplasmic, score: 23 YP_001456221.1 Psort location: nuclear, score: 23 YP_001456222.1 Psort location: mitochondrial, score: 23 YP_001456223.1 KEGG: sec:SC3376 1.9e-59 hopD; leader peptidase HopD K02506; COG: COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases; Psort location: endoplasmic reticulum, score: 9 YP_001456224.1 iron storage protein YP_001456225.1 KEGG: ppr:PBPRA2525 0.0043 hypothetical nitrate reductase large subunit K00372; COG: COG2906 Bacterioferritin-associated ferredoxin; Psort location: cytoplasmic, score: 23 YP_001456226.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001456227.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001456228.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001456230.1 COG: COG2168 Uncharacterized conserved protein involved in oxidation of intracellular sulfur; Psort location: cytoplasmic, score: 23 YP_001456231.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_001456232.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_001456233.1 COG: COG2964 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001456234.1 rotamase YP_001456235.1 COG: COG2900 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001456236.1 rotamase YP_001456237.1 Psort location: endoplasmic reticulum, score: 9 YP_001456238.1 COG: COG3529 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain; Psort location: extracellular, including cell wall, score: 9 YP_001456239.1 involved in potassium efflux YP_001456240.1 required for KefB activity YP_001456241.1 KEGG: pen:PSEEN0163 1.8e-187 ABC transporter, ATP-binding protein; COG: COG0488 ATPase components of ABC transporters with duplicated ATPase domains; Psort location: nuclear, score: 23 YP_001456242.1 KEGG: shn:Shewana3_3435 1.6e-07 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001456243.1 KEGG: pst:PSPTO_5081 3.1e-73 malonyl CoA-acyl carrier protein transacylase, putative K00645; COG: COG0331 (acyl-carrier-protein) S-malonyltransferase; Psort location: cytoplasmic, score: 23 YP_001456244.1 Catalyzes the transfer of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A to the apo-acyl carrier protein of malonate dehydrogenase to form holo-acyl carrier protein YP_001456245.1 KEGG: azo:azo2534 5.6e-19 mdcF2; putative malonate transporter; COG: COG0679 Predicted permeases; Psort location: plasma membrane, score: 23 YP_001456246.1 KEGG: tko:TK1622 0.0019 methylmalonyl-CoA decarboxylase, alpha subunit K01604; COG: NOG08721 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456247.1 The beta subunit catalyzes the decarboxylation of the malonyl moiety on coenzyme A YP_001456248.1 COG: NOG17082 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456249.1 KEGG: pfo:Pfl_5301 7.2e-74 triphosphoribosyl-dephospho-CoA protein K05966; COG: COG1767 Triphosphoribosyl-dephospho-CoA synthetase; Psort location: cytoplasmic, score: 23 YP_001456250.1 KEGG: reh:H16_A2718 0.00054 pct; propionate CoA-transferase K01026; COG: NOG05983 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456251.1 Psort location: nuclear, score: 23 YP_001456252.1 COG: COG0429 Predicted hydrolase of the alpha/beta-hydrolase fold; Psort location: cytoplasmic, score: 23 YP_001456253.1 COG: COG3089 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001456254.1 KEGG: spt:SPA3330 1.9e-153 prkB; phosphoribulokinase K00855; COG: COG3954 Phosphoribulokinase; Psort location: cytoplasmic, score: 23 YP_001456255.1 Psort location: mitochondrial, score: 23 YP_001456256.1 COG: COG1765 Predicted redox protein, regulator of disulfide bond formation; Psort location: cytoplasmic, score: 23 YP_001456257.1 Psort location: mitochondrial, score: 23 YP_001456258.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons YP_001456259.1 KEGG: ssn:SSO_3489 0. yhfK; hypothetical protein K01823; COG: COG1289 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001456260.1 COG: COG1226 Kef-type K+ transport systems, predicted NAD-binding component; Psort location: cytoplasmic, score: 23 YP_001456261.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate YP_001456262.1 Psort location: mitochondrial, score: 23 YP_001456263.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity YP_001456264.1 COG: COG2184 Protein involved in cell division; Psort location: cytoplasmic, score: 23 YP_001456265.1 COG: NOG18128 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001456266.1 KEGG: spt:SPA3338 2.8e-95 ppiA; peptidyl-prolyl cis-trans isomerase K03767; COG: COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; Psort location: extracellular, including cell wall, score: 9 YP_001456267.1 KEGG: sso:SSO0328 0.0066 nuoL; NADH dehydrogenase I chain L, M K00341:K00342; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001456268.1 Psort location: nuclear, score: 23 YP_001456269.1 Psort location: nuclear, score: 23 YP_001456270.1 KEGG: stm:STM3474 0. nirB; nitrite reductase, large subunit K00362; COG: COG1251 NAD(P)H-nitrite reductase; Psort location: cytoplasmic, score: 23 YP_001456271.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations YP_001456272.1 member of the FNT family of formate and nitrite transporters YP_001456273.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin YP_001456274.1 KEGG: eci:UTI89_C1627 0. entS; EntS/YbdA MFS transporter; COG: COG5295 Autotransporter adhesin; Psort location: cytoplasmic, score: 23 YP_001456275.1 COG: NOG13903 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001456276.1 Psort location: mitochondrial, score: 23 YP_001456277.1 KEGG: tfu:Tfu_0632 7.7e-08 cystaTHIonine gamma-synthase K01739; COG: NOG06470 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456278.1 COG: NOG06469 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001456279.1 COG: NOG09776 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456280.1 phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE) YP_001456281.1 KEGG: eci:UTI89_C3878 3.0e-178 yhfW; hypothetical protein YhfW K01618; COG: COG1015 Phosphopentomutase; Psort location: cytoplasmic, score: 23 YP_001456282.1 KEGG: ctc:CTC02513 0.00019 alr; alanine racemase K01775; COG: COG3457 Predicted amino acid racemase; Psort location: cytoplasmic, score: 23 YP_001456283.1 COG: NOG10265 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456284.1 COG: NOG06213 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001456285.1 Psort location: nuclear, score: 23 YP_001456286.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001456287.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_001456288.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_001456289.1 KEGG: stm:STM3484 2.4e-130 dam; DNA adenine methylase K06223; COG: COG0338 Site-specific DNA methylase; Psort location: cytoplasmic, score: 23 YP_001456290.1 KEGG: abo:ABO_1060 3.3e-11 rne; phosphoric diester hydrolase K08300; COG: COG3266 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001456291.1 Psort location: nuclear, score: 23 YP_001456292.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_001456293.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_001456294.1 KEGG: ecc:c4160 2.7e-12 aroK; shikimate kinase I K00891; COG: COG0703 Shikimate kinase; Psort location: cytoplasmic, score: 23; ORF located using Blastx YP_001456295.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa YP_001456296.1 COG: NOG12171 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001456297.1 COG: NOG13913 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001456298.1 COG: COG3166 Tfp pilus assembly protein PilN; Psort location: endoplasmic reticulum, score: 9 YP_001456299.1 COG: NOG05966 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456300.2 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits YP_001456301.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_001456302.1 COG: NOG06324 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001456303.1 KEGG: rso:RSc2880 1.3e-07 gph, RS00222; probable phosphoglycolate phosphatase protein K01091; COG: COG1011 Predicted hydrolase (HAD superfamily); Psort location: cytoplasmic, score: 23 YP_001456304.1 COG: COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog); Psort location: nuclear, score: 23 YP_001456305.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_001456306.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_001456307.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR YP_001456308.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation YP_001456309.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001456310.1 KEGG: bur:Bcep18194_A5099 1.2e-245 RNA binding S1; COG: COG2183 Transcriptional accessory protein; Psort location: cytoplasmic, score: 23 YP_001456311.1 COG: COG1918 Fe2+ transport system protein A; Psort location: cytoplasmic, score: 23 YP_001456312.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake YP_001456313.1 COG: NOG13904 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001456314.1 KEGG: eci:UTI89_C3913 6.9e-117 bioH; carboxylesterase involved in biosynthesis of pimeloyl-CoA/carboxylesterase K02170; COG: COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Psort location: cytoplasmic, score: 23 YP_001456315.1 involved in high-affinity gluconate transport YP_001456316.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source YP_001456317.1 KEGG: eci:UTI89_C3106 2.0e-69 ygbN; hypothetical permease YgbN K03299; COG: COG2610 H+/gluconate symporter and related permeases; Psort location: plasma membrane, score: 23 YP_001456318.1 amylomaltase; acts to release glucose from maltodextrins YP_001456319.1 KEGG: stm:STM3514 0. malP; maltodextrin phosphorylase K00688; COG: COG0058 Glucan phosphorylase; Psort location: cytoplasmic, score: 23 YP_001456320.1 Psort location: mitochondrial, score: 23 YP_001456321.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides YP_001456322.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism YP_001456323.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity YP_001456324.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine YP_001456325.1 Psort location: cytoplasmic, score: 23 YP_001456326.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_001456327.1 Psort location: mitochondrial, score: 23 YP_001456328.1 KEGG: spt:SPA3385 0. glgP; glycogen phosphorylase K00688; COG: COG0058 Glucan phosphorylase; Psort location: cytoplasmic, score: 23 YP_001456329.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_001456330.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_001456331.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen YP_001456332.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_001456333.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_001456334.1 Psort location: nuclear, score: 23 YP_001456335.1 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP) YP_001456336.1 KEGG: eci:UTI89_C3106 1.6e-62 ygbN; hypothetical permease YgbN K03299; COG: COG2610 H+/gluconate symporter and related permeases; Psort location: plasma membrane, score: 23 YP_001456337.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate YP_001456338.1 KEGG: efa:EF1922 2.0e-07 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001456339.1 KEGG: shn:Shewana3_3385 2.0e-13 hypoxanTHIne phosphoribosyltransferase K00760; COG: COG1741 Pirin-related protein; Psort location: cytoplasmic, score: 23 YP_001456340.1 KEGG: eco:b3440 7.2e-177 yhhX; predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001456341.1 YhhY; regulated by the fur regulator; unknown function YP_001456342.1 KEGG: eci:UTI89_C0121 8.1e-59 usp; uropathogenic specific protein K01150; COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: cytoplasmic, score: 23 YP_001456343.1 Psort location: cytoplasmic, score: 23 YP_001456344.1 Psort location: cytoplasmic, score: 23 YP_001456345.1 Psort location: nuclear, score: 23 YP_001456346.1 Psort location: nuclear, score: 23 YP_001456347.1 Psort location: mitochondrial, score: 23 YP_001456348.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides YP_001456349.1 KEGG: ddi:DDB0215408 1.1e-06 pkaC; AGC family protein kinase K04345; COG: NOG08680 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001456350.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate YP_001456351.1 part of the UgpABCE glycerol-3-phosphate uptake system YP_001456352.1 with UgpABC is involved in uptake of glycerol-3-phosphate YP_001456353.1 with UgpEC is involved in the uptake of glycerol-3-phosphate YP_001456354.1 with UgpACE is involved in the uptake of glycerol-3-phosphate YP_001456355.1 Psort location: mitochondrial, score: 23 YP_001456356.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_001456357.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_001456358.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_001456359.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter YP_001456360.1 KEGG: ava:Ava_2791 0.0017 serine/threonine protein kinase K00903; COG: COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001456361.1 Psort location: cytoplasmic, score: 23 YP_001456362.1 KEGG: reh:H16_B0069 2.1e-05 acetyltransferase K00680; COG: NOG09777 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456363.1 KEGG: ava:Ava_2791 0.0036 serine/threonine protein kinase K00903; COG: COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component; Psort location: cytoplasmic, score: 23 YP_001456364.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_001456365.1 Psort location: cytoplasmic, score: 23 YP_001456366.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_001456367.1 Psort location: nuclear, score: 23 YP_001456368.1 Psort location: cytoplasmic, score: 23 YP_001456369.1 putative ABC transporter, membrane protein YP_001456370.1 putative ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions YP_001456371.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins YP_001456372.1 Psort location: nuclear, score: 23 YP_001456373.1 catalyzes the methylation of 16S rRNA at position G966 YP_001456374.1 COG: COG3776 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001456375.1 COG: NOG09778 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001456376.1 Psort location: nuclear, score: 23 YP_001456377.1 COG: COG3714 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001456378.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury YP_001456379.1 COG: COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001456380.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs YP_001456381.1 COG: COG1738 Uncharacterized conserved protein; Psort location: endoplasmic reticulum, score: 9 YP_001456382.1 COG: NOG07879 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001456383.1 KEGG: ece:Z3534 0.0014 nuoN; NADH dehydrogenase I chain N K00343; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001456384.1 KEGG: tbd:Tbd_2668 4.3e-11 phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthetase K01923; COG: COG0628 Predicted permease; Psort location: plasma membrane, score: 23 YP_001456385.1 Psort location: nuclear, score: 23 YP_001456386.1 Psort location: cytoplasmic, score: 23 YP_001456387.1 COG: NOG17956 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001456388.1 KEGG: rha:RHA1_ro00739 2.9e-11 polyketide synthesis 8-O-methyltransferase K00599; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001456389.1 COG: NOG16918 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456390.1 KEGG: vfi:VF0845 5.7e-58 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655; COG: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; Psort location: cytoplasmic, score: 23 YP_001456391.1 KEGG: hpa:HPAG1_0538 0.00049 acyl carrier protein K01162; COG: COG0236 Acyl carrier protein; Psort location: cytoplasmic, score: 23 YP_001456392.1 carries the fatty acid chain in fatty acid biosynthesis YP_001456393.1 COG: COG4648 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 23 YP_001456394.1 KEGG: shn:Shewana3_0338 4.3e-53 aconitate hydratase K01680; COG: COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases; Psort location: mitochondrial, score: 23 YP_001456395.1 KEGG: stt:t0228 0.00019 fabZ; (3R)-hydroxymyristol acyl carrier protein dehydrase K02372; COG: COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases; Psort location: cytoplasmic, score: 23 YP_001456396.1 KEGG: azo:azo3917 1.2e-48 glycosyltransferase; COG: COG4261 Predicted acyltransferase; Psort location: cytoplasmic, score: 23 YP_001456397.1 KEGG: vfi:VF0853 1.2e-34 esterase; COG: COG0824 Predicted THIoesterase; Psort location: cytoplasmic, score: 23 YP_001456398.1 COG: NOG17955 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001456399.1 COG: COG4258 Predicted exporter; Psort location: plasma membrane, score: 23 YP_001456400.1 KEGG: vfi:VF0856 3.6e-17 phospho-N-acetylmuramoyl-pentapeptide-transferase K01000; COG: NOG17954 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001456401.1 FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001456402.1 KEGG: eca:ECA4493 2.6e-37 putative beta-hydroxydecanoyl-ACP dehydrase K01726; COG: COG4706 Predicted 3-hydroxylacyl-(acyl carrier protein) dehydratase; Psort location: cytoplasmic, score: 23 YP_001456403.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001456404.1 FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001456405.1 KEGG: sty:STY4228 1.1e-84 4'-phosphopantetheinyl transferase K06133; COG: COG2091 Phosphopantetheinyl transferase; Psort location: mitochondrial, score: 23 YP_001456406.1 KEGG: shn:Shewana3_2650 1.9e-23 acetate kinase K00925; COG: COG0747 ABC-type dipeptide transport system, periplasmic component; Psort location: cytoplasmic, score: 23 YP_001456407.1 with NikACDE is involved in nickel transport into the cell YP_001456408.1 with NikABDE is involved in nickel transport into the cell YP_001456409.1 with NikABCE is involved in nickel transport into the cell YP_001456410.1 with NikABCD is involved with nickel transport into the cell YP_001456411.1 Inhibits transcription at high concentrations of nickel YP_001456412.1 Psort location: mitochondrial, score: 23 YP_001456413.1 Psort location: nuclear, score: 23 YP_001456414.1 KEGG: fal:FRAAL1796 1.2e-10 putative ABC transporter ATP-binding subunit; COG: COG0842 ABC-type multidrug transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001456415.1 KEGG: rru:Rru_A1792 3.8e-84 ABC transporter component K01990; COG: COG1131 ABC-type multidrug transport system, ATPase component; Psort location: endoplasmic reticulum, score: 9 YP_001456416.1 KEGG: eci:UTI89_C0735 1.0e-06 tolA; membrane spanning protein TolA K03646; COG: COG0845 Membrane-fusion protein; Psort location: endoplasmic reticulum, score: 9 YP_001456417.1 Psort location: nuclear, score: 23 YP_001456418.1 Psort location: mitochondrial, score: 23 YP_001456419.1 KEGG: pmt:PMT0126 1.3e-35 MgtE family, putative magnesium transport protein K06213; COG: COG2239 Mg/Co/Ni transporter MgtE (contains CBS domain); Psort location: endoplasmic reticulum, score: 9 YP_001456420.1 KEGG: bur:Bcep18194_A4651 1.3e-05 dihydrolipoamide dehydrogenase K00382; COG: COG2081 Predicted flavoproteins; Psort location: cytoplasmic, score: 23 YP_001456421.1 COG: COG0306 Phosphate/sulphate permeases; Psort location: plasma membrane, score: 23 YP_001456422.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress YP_001456423.1 COG: COG0589 Universal stress protein UspA and related nucleotide-binding proteins; Psort location: cytoplasmic, score: 23 YP_001456424.1 Psort location: mitochondrial, score: 23 YP_001456425.1 member of the POT family of peptide transporters; probable proton-dependent peptide transporter function YP_001456426.1 COG: COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system; Psort location: cytoplasmic, score: 23 YP_001456427.1 Psort location: vesicles of secretory system, score: 9 YP_001456428.1 COG: NOG13920 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001456429.1 KEGG: ama:AM656 5.2e-08 aminotransferase, class V K04487; COG: COG1959 Predicted transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001456430.1 Psort location: cytoplasmic, score: 23 YP_001456431.1 KEGG: pfo:Pfl_2451 9.2e-122 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885; COG: COG1252 NADH dehydrogenase, FAD-containing subunit; Psort location: extracellular, including cell wall, score: 9 YP_001456432.1 predicted SAM-dependent methyltransferase YP_001456433.1 KEGG: ecc:c4297 0. prlC; oligopeptidase A K01414; COG: COG0339 Zn-dependent oligopeptidases; Psort location: cytoplasmic, score: 23 YP_001456434.1 Psort location: cytoplasmic, score: 23 YP_001456435.1 COG: COG2961 Protein involved in catabolism of external DNA; Psort location: cytoplasmic, score: 23 YP_001456436.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_001456437.1 KEGG: ssn:SSO_3568 1.0e-225 yhjA; putative cytochrome c peroxidase K00428; COG: COG1858 Cytochrome c peroxidase; Psort location: endoplasmic reticulum, score: 9 YP_001456438.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose YP_001456439.1 KEGG: pmt:PMT0154 0.0047 eukaryotic protein kinase:serine/threonine protein kinase K08884; COG: NOG26124 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001456440.1 KEGG: pen:PSEEN1303 8.5e-87 oxidoreductase, short-chain alcohol dehydrogenase/reductase family; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: mitochondrial, score: 23 YP_001456441.1 KEGG: shn:Shewana3_3435 1.1e-11 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001456442.1 KEGG: eci:UTI89_C4054 7.9e-155 yhjD; hypothetical protein; COG: COG1295 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001456443.1 Psort location: cytoplasmic, score: 23 YP_001456444.1 KEGG: cal:orf19.2425 0.00016 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001456445.1 COG: COG2982 Uncharacterized protein involved in outer membrane biogenesis; Psort location: endoplasmic reticulum, score: 9 YP_001456446.1 Psort location: nuclear, score: 23 YP_001456447.1 in Escherichia coli this protein is involved in flagellar function YP_001456448.1 KEGG: stm:STM3612 6.6e-151 kdgK; ketodeoxygluconokinase K00874; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001456449.1 KEGG: eci:UTI89_C4059 4.2e-236 yhjJ; protein YhjJ precursor K01412; COG: COG0612 Predicted Zn-dependent peptidases; Psort location: extracellular, including cell wall, score: 9 YP_001456450.1 involved in the transport of C4-dicarboxylates across the membrane YP_001456451.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a putative phosphodiesterase protein from E. coli YP_001456452.1 KEGG: sec:SC4127 0.0030 tyrB; tyrosine aminotransferase, tyrosine repressible K00832; Psort location: mitochondrial, score: 23 YP_001456453.1 cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA YP_001456454.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans YP_001456455.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP) YP_001456456.1 Psort location: nuclear, score: 23 YP_001456457.1 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis YP_001456458.1 COG: COG1192 ATPases involved in chromosome partitioning; Psort location: extracellular, including cell wall, score: 9 YP_001456459.1 COG: NOG13865 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001456460.1 Psort location: mitochondrial, score: 23 YP_001456461.1 KEGG: vfi:VFA0886 8.9e-26 zinc metalloprotease; COG: NOG14695 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456462.1 COG: NOG15366 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456463.1 COG: NOG05994 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001456464.1 Psort location: cytoplasmic, score: 23 YP_001456465.1 KEGG: tde:TDE2200 6.7e-126 megL; meTHIonine gamma-lyase K01761; COG: COG0626 CystaTHIonine beta-lyases/cystaTHIonine gamma-synthases; Psort location: cytoplasmic, score: 23 YP_001456466.1 Psort location: nuclear, score: 23 YP_001456467.1 COG: COG0814 Amino acid permeases; Psort location: plasma membrane, score: 23 YP_001456468.1 KEGG: eci:UTI89_C2502 1.3e-65 atoC; acetoacetate metabolism regulatory protein AtoC K07714; COG: COG3283 Transcriptional regulator of aromatic amino acids metabolism; Psort location: cytoplasmic, score: 23 YP_001456469.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides YP_001456470.1 Psort location: cytoplasmic, score: 23 YP_001456471.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF YP_001456472.1 KEGG: bpm:BURPS1710b_A0449 5.3e-05 glycine betaine/L-proline ABC transporter, permease protein K02001; COG: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001456473.1 transports peptides consisting of two or three amino acids YP_001456474.1 KEGG: shn:Shewana3_2650 4.3e-124 acetate kinase K00925; COG: COG0747 ABC-type dipeptide transport system, periplasmic component; Psort location: cytoplasmic, score: 23 YP_001456475.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide YP_001456476.1 KEGG: rpc:RPC_2666 0.0052 V-type H(+)-translocating pyrophosphatase K01507; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001456477.1 COG: COG5571 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion; Psort location: extracellular, including cell wall, score: 9 YP_001456478.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine YP_001456479.1 KEGG: sty:STY4159 3.2e-64 yiaC; putative acetyltransferase K03826; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001456480.1 KEGG: stm:STM3644 0. bisC; biotin sulfoxide reductase K08351; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001456481.1 Psort location: mitochondrial, score: 23 YP_001456482.1 Psort location: mitochondrial, score: 23 YP_001456483.1 KEGG: bxe:Bxe_A4171 8.0e-05 putative cytochrome c oxidase K00403; COG: COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; Psort location: extracellular, including cell wall, score: 9 YP_001456484.1 KEGG: efa:EF1922 0.00037 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001456485.1 COG: NOG13334 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456486.1 KEGG: bur:Bcep18194_A5029 1.3e-104 sugar kinase, ribokinase family K00874; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001456487.1 KEGG: cal:orf19.2425 0.0039 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001456488.1 KEGG: eco:b3553 2.5e-151 tkrA, yiaE; 2-keto-D-gluconate reductase (2-ketoaldonate reductase) K00090; COG: COG1052 Lactate dehydrogenase and related dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001456489.1 COG: NOG06217 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001456490.1 COG: COG2944 Predicted transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001456491.1 Psort location: cytoplasmic, score: 23 YP_001456492.1 COG: COG1278 Cold shock proteins; Psort location: cytoplasmic, score: 23 YP_001456493.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001456494.1 Psort location: cytoplasmic, score: 23 YP_001456495.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001456496.1 COG: NOG10996 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001456497.1 COG: COG3274 Uncharacterized protein conserved in bacteria; Psort location: plasma membrane, score: 23 YP_001456498.1 COG: COG4682 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001456499.1 KEGG: spt:SPA3511 2.6e-236 xylB; xylulose kinase K00854; COG: COG1070 Sugar (pentulose and hexulose) kinases; Psort location: cytoplasmic, score: 23 YP_001456500.1 catalyzes the interconversion of D-xylose to D-xylulose YP_001456501.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity YP_001456502.1 with XylFH is part of the high affinity xylose ABC transporter YP_001456503.1 KEGG: msm:MSMEG_1706 1.5e-66 xylose transport system permease protein XylH; COG: COG4214 ABC-type xylose transport system, permease component; Psort location: plasma membrane, score: 23 YP_001456504.1 Psort location: nuclear, score: 23 YP_001456505.1 KEGG: bcz:BCZK2914 1.7e-10 adaA; methylphosphotriester-DNA alkyltransferase K00567; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001456506.1 KEGG: lpl:lp_2645 0.00014 acm2; muramidase K01185; COG: COG2992 Uncharacterized FlgJ-related protein; Psort location: extracellular, including cell wall, score: 9 YP_001456507.1 Psort location: mitochondrial, score: 23 YP_001456508.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds YP_001456509.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis YP_001456510.1 KEGG: eci:UTI89_C4115 4.7e-70 ysaA, yiaI; putative electron transport protein YsaA K00122; COG: COG1142 Fe-S-cluster-containing hydrogenase components 2; Psort location: cytoplasmic, score: 23 YP_001456511.1 KEGG: tth:TTC0885 3.7e-08 acetyl-coenzyme A synthetase K01895; COG: COG1414 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001456512.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate YP_001456513.1 COG: COG2731 Beta-galactosidase, beta subunit; Psort location: cytoplasmic, score: 23 YP_001456514.1 COG: NOG11374 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456515.1 KEGG: cal:orf19.2425 0.0038 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001456516.1 Psort location: extracellular, including cell wall, score: 9 YP_001456517.1 KEGG: stm:STM3674 5.5e-234 lyxK; L-xylulose kinase K00880; COG: COG1070 Sugar (pentulose and hexulose) kinases; Psort location: mitochondrial, score: 23 YP_001456518.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate YP_001456519.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate YP_001456520.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_001456521.1 Psort location: cytoplasmic, score: 23 YP_001456522.1 KEGG: stm:STM3680 5.6e-273 aldB; aldehyde dehydrogenase B K00138; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001456523.1 Psort location: nuclear, score: 23 YP_001456524.1 KEGG: ecc:c4410 1.9e-183 yiaY; probable alcohol dehydrogenase K00001; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: cytoplasmic, score: 23 YP_001456525.1 KEGG: eci:UTI89_C4132 3.2e-286 selB; selenocysteine-specific elongation factor K03833; COG: COG3276 Selenocysteine-specific translation elongation factor; Psort location: cytoplasmic, score: 23 YP_001456526.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis YP_001456527.1 KEGG: eci:UTI89_C4134 2.8e-95 yibF; putative S-transferase K00799; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001456528.1 Psort location: nuclear, score: 23 YP_001456529.1 Psort location: cytoplasmic, score: 23 YP_001456530.1 COG: COG1566 Multidrug resistance efflux pump; Psort location: endoplasmic reticulum, score: 9 YP_001456531.1 COG: NOG10266 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456532.1 Psort location: cytoplasmic, score: 23 YP_001456533.1 KEGG: stm:STM3685 0. mtlA; PTS family, mannitol-specific enzyme IIABC components K02798:K02799:K02800; COG: COG4668 Mannitol/fructose-specific phosphotransferase system, IIA domain; Psort location: plasma membrane, score: 23 YP_001456534.1 KEGG: sec:SC3610 2.8e-191 mtlD; mannitol-1-phosphate dehydrogenase K00009; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001456535.1 Acts as a repressor of the mtlAD operon YP_001456536.1 KEGG: eca:ECA2363 0.00080 DNA polymerase III, theta subunit K00961; COG: NOG18544 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001456537.1 COG: NOG10267 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456538.1 COG: COG1620 L-lactate permease; Psort location: plasma membrane, score: 23 YP_001456539.1 represses the lctPRD operon YP_001456540.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration YP_001456541.1 Psort location: mitochondrial, score: 23 YP_001456542.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates YP_001456543.1 catalyzes the O-acetylation of serine YP_001456544.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_001456545.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_001456546.1 KEGG: eci:UTI89_C4152 1.8e-38 grxC; glutaredoxin 3 K03676; COG: COG0695 Glutaredoxin and related proteins; Psort location: cytoplasmic, score: 23 YP_001456547.1 KEGG: pha:PSHAa0367 2.2e-26 rhodanese sulfur transferase K01010; COG: COG0607 Rhodanese-related sulfurtransferase; Psort location: cytoplasmic, score: 23 YP_001456548.1 Psort location: mitochondrial, score: 23 YP_001456549.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_001456550.2 KEGG: cya:CYA_1627 5.5e-28 peptidase, M23B family; COG: COG4942 Membrane-bound metallopeptidase; Psort location: nuclear, score: 23 YP_001456551.1 Psort location: cytoplasmic, score: 23 YP_001456552.1 COG: COG2861 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001456553.1 KEGG: sty:STY4088 1.9e-153 putative glycosyltransferase; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001456554.1 KEGG: ssn:SSO_3780 8.9e-21 waaY; lipopolysaccharide core biosynthesis K02850; COG: NOG10262 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001456555.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism YP_001456556.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_001456557.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose YP_001456558.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core YP_001456559.1 KEGG: sbo:SBO_3626 3.3e-140 rfaC; heptosyl transferase I K02841; COG: COG0859 ADP-heptose:LPS heptosyltransferase; Psort location: cytoplasmic, score: 23 YP_001456560.1 KEGG: ecj:JW3597 8.2e-50 rfaL; O-antigen ligase K02847; COG: COG3307 Lipid A core - O-antigen ligase and related enzymes; Psort location: plasma membrane, score: 23 YP_001456561.1 KEGG: sty:STY4088 6.5e-21 putative glycosyltransferase; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001456562.1 KEGG: eca:ECA0160 1.8e-86 waaQ, rfaQ; lipopolysaccharide core biosynthesis glycosyl transferase rfaq K02849; COG: COG0859 ADP-heptose:LPS heptosyltransferase; Psort location: cytoplasmic, score: 23 YP_001456563.1 KEGG: eca:ECA0157 2.0e-30 waaJ, rfaJ; lipopolysaccharide 1,2-glucosyltransferase K03279; COG: COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases; Psort location: cytoplasmic, score: 23 YP_001456564.1 KEGG: eca:ECA0157 2.8e-79 waaJ, rfaJ; lipopolysaccharide 1,2-glucosyltransferase K03279; COG: COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases; Psort location: cytoplasmic, score: 23 YP_001456565.1 KEGG: sbo:SBO_3630 2.5e-71 waaJ; lipopolysaccharide 1,2-glucosyltransferase K03279; COG: COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases; Psort location: cytoskeletal, score: 9 YP_001456566.1 KEGG: ecc:c4454 2.3e-102 rfaP; lipopolysaccharide core biosynthesis protein rfaP K02848; COG: NOG06227 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456567.1 KEGG: ecc:c4455 4.1e-142 rfaG; lipopolysaccharide core biosynthesis protein rfaG K02844; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001456568.1 Psort location: mitochondrial, score: 23 YP_001456569.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_001456570.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_001456571.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_001456572.1 Psort location: mitochondrial, score: 23 YP_001456573.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001456574.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_001456575.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_001456576.1 catalyzes the formation of dUMP from dUTP YP_001456577.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly YP_001456578.1 Psort location: nuclear, score: 23 YP_001456579.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001456580.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_001456581.1 COG: COG1561 Uncharacterized stress-induced protein; Psort location: cytoplasmic, score: 23 YP_001456582.1 COG: COG2860 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001456583.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+ YP_001456584.1 Essential for recycling GMP and indirectly, cGMP YP_001456585.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_001456586.1 KEGG: spt:SPA3594 0. spoT; Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; CG Site No. 156 K01139; COG: COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; Psort location: cytoplasmic, score: 23 YP_001456587.1 specifically modifies tRNA at position G18 YP_001456588.1 catalyzes branch migration in Holliday junction intermediates YP_001456589.1 Psort location: nuclear, score: 23 YP_001456590.1 KEGG: hpa:HPAG1_1114 0.0038 hypothetical protein K00760; COG: COG2233 XanTHIne/uracil permeases; Psort location: plasma membrane, score: 23 YP_001456591.1 COG: NOG06061 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001456592.1 Psort location: mitochondrial, score: 23 YP_001456593.1 Psort location: cytoplasmic, score: 23 YP_001456594.1 KEGG: shn:Shewana3_3435 4.0e-05 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001456595.1 KEGG: pen:PSEEN2731 1.2e-117 alcohol dehydrogenase, zinc-containing K00345; COG: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001456596.1 KEGG: tws:TW418 6.9e-05 phosphate ABC transporter ATP-binding protein K02036; COG: COG4637 Predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001456597.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001456598.1 Psort location: cytoplasmic, score: 23 YP_001456599.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001456600.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001456601.1 KEGG: chu:CHU_1336 0.0021 CHU large protein; endoglucanase-related protein, glycoside hydrolase family 9 protein K01238; COG: COG3188 P pilus assembly protein, porin PapC; Psort location: endoplasmic reticulum, score: 9 YP_001456602.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001456603.1 KEGG: chu:CHU_1155 0.0013 CHU large protein; candidate xyloglucanase, glycoside hydrolase family 74 protein K01238; COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001456604.1 Psort location: nuclear, score: 23 YP_001456605.1 COG: COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen; Psort location: mitochondrial, score: 23 YP_001456606.1 COG: NOG14137 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456607.1 KEGG: stm:STM3768 1.6e-170 putative selenocysteine synthase [L-seryl-tRNA(Ser) selenium transferase K01042; COG: COG1921 Selenocysteine synthase [seryl-tRNASer selenium transferase]; Psort location: cytoplasmic, score: 23 YP_001456608.1 KEGG: lsl:LSL_1949 6.6e-48 PTS system, mannose-specific IID component K00890; COG: COG3716 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID; Psort location: plasma membrane, score: 23 YP_001456609.1 KEGG: lsl:LSL_1950 2.3e-29 PTS system, mannose-specific IIC component K00890; COG: COG3715 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC; Psort location: endoplasmic reticulum, score: 9 YP_001456610.1 KEGG: spt:SPA3621 8.7e-78 putative PTS system protein K02794; COG: COG3444 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB; Psort location: cytoplasmic, score: 23 YP_001456611.1 KEGG: sec:SC3692 1.0e-60 putative phosphotransferase system enzyme IIA K02793; COG: COG2893 Phosphotransferase system, mannose/fructose-specific component IIA; Psort location: cytoplasmic, score: 23 YP_001456612.1 Psort location: nuclear, score: 23 YP_001456613.1 KEGG: reh:H16_A2683 2.9e-21 response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K01529; COG: COG3933 Transcriptional antiterminator; Psort location: cytoplasmic, score: 23 YP_001456614.1 COG: NOG12179 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001456615.1 experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS YP_001456616.1 COG: NOG09018 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456617.1 COG: COG1414 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001456618.1 KEGG: rpc:RPC_4382 3.3e-78 dihydrodipicolinate synthetase K01714; COG: COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Psort location: endoplasmic reticulum, score: 9 YP_001456619.1 Psort location: cytoplasmic, score: 23 YP_001456620.1 Psort location: cytoplasmic, score: 23 YP_001456621.1 COG: NOG22282 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001456622.1 COG: NOG23110 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001456623.1 Psort location: cytoplasmic, score: 23; ORF located using Blastx YP_001456624.1 Psort location: nuclear, score: 23; ORF located using Blastx YP_001456625.1 Psort location: extracellular, including cell wall, score: 9 YP_001456626.1 Psort location: cytoplasmic, score: 23 YP_001456627.1 KEGG: ddi:DDB0167703 0.00020 hypothetical protein K01971; COG: COG3210 Large exoproteins involved in heme utilization or adhesion; Psort location: nuclear, score: 23 YP_001456628.1 Psort location: nuclear, score: 23 YP_001456629.1 Psort location: extracellular, including cell wall, score: 9 YP_001456630.1 Psort location: mitochondrial, score: 23 YP_001456631.1 Psort location: cytoplasmic, score: 23 YP_001456632.1 Psort location: nuclear, score: 23 YP_001456633.1 Psort location: cytoplasmic, score: 23 YP_001456634.1 Psort location: nuclear, score: 23 YP_001456635.1 Psort location: cytoplasmic, score: 23 YP_001456636.1 KEGG: reh:H16_A2580 3.7e-07 cafA2; ribonuclease G and E; COG: COG0419 ATPase involved in DNA repair; Psort location: nuclear, score: 23 YP_001456637.1 Psort location: nuclear, score: 23; ORF located using Blastx YP_001456638.1 COG: COG4710 Predicted DNA-binding protein with an HTH domain; Psort location: nuclear, score: 23 YP_001456639.1 COG: COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system; Psort location: cytoplasmic, score: 23 YP_001456640.1 Psort location: cytoplasmic, score: 23 YP_001456641.1 Psort location: endoplasmic reticulum, score: 9 YP_001456642.1 Psort location: cytoplasmic, score: 23 YP_001456643.1 Psort location: nuclear, score: 23 YP_001456644.1 Psort location: extracellular, including cell wall, score: 9 YP_001456645.1 Psort location: mitochondrial, score: 23; ORF located using Blastx YP_001456646.1 Psort location: nuclear, score: 23; ORF located using Blastx