-- dump date 20140619_042049 -- class Genbank::misc_feature -- table misc_feature_note -- id note 637910000001 HMMPfam hit to PF08254, Thr operon leader peptide, score 7.6e-07 637910000002 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 637910000003 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 637910000004 putative catalytic residues [active] 637910000005 putative nucleotide binding site [chemical binding]; other site 637910000006 putative aspartate binding site [chemical binding]; other site 637910000007 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 637910000008 dimer interface [polypeptide binding]; other site 637910000009 putative threonine allosteric regulatory site; other site 637910000010 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 637910000011 putative threonine allosteric regulatory site; other site 637910000012 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 637910000013 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 637910000014 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 1.3e-64 637910000015 PS00324 Aspartokinase signature. 637910000016 HMMPfam hit to PF01842, Amino acid-binding ACT, score 1.6e-05 637910000017 HMMPfam hit to PF01842, Amino acid-binding ACT, score 3.8e-07 637910000018 HMMPfam hit to PF03447, Aspartate/homoserine dehydrogenase, NAD-binding, score 1.1e-48 637910000019 HMMPfam hit to PF00742, Homoserine dehydrogenase, catalytic, score 5.3e-104 637910000020 PS01042 Homoserine dehydrogenase signature. 637910000021 homoserine kinase; Region: thrB; TIGR00191 637910000022 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 637910000023 HMMPfam hit to PF00288, GHMP kinase, score 3.1e-20 637910000024 PS00627 GHMP kinases ATP-binding domain. 637910000025 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000026 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 3.6e-09 637910000027 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 637910000028 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 637910000029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910000030 catalytic residue [active] 637910000031 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 1.7e-34 637910000032 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 637910000033 hypothetical protein; Validated; Region: PRK02101 637910000034 HMMPfam hit to PF03883, Protein of unknown function DUF328, score 1.5e-171 637910000035 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 637910000036 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 637910000037 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 637910000038 HMMPfam hit to PF01235, Sodium:alanine symporter, score 5.7e-248 637910000039 9 transmembrane helices predicted for ROD00051 by TMHMM2.0 at aa 13-35, 76-98, 136-158, 171-193, 203-225, 301-323, 343-365, 386-405 and 415-437 637910000040 PS00873 Sodium:alanine symporter family signature. 637910000041 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000042 transaldolase-like protein; Provisional; Region: PTZ00411 637910000043 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 637910000044 active site 637910000045 dimer interface [polypeptide binding]; other site 637910000046 catalytic residue [active] 637910000047 HMMPfam hit to PF00923, Transaldolase, score 3.2e-188 637910000048 PS01054 Transaldolase signature 1. 637910000049 PS00958 Transaldolase active site. 637910000050 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 637910000051 MPT binding site; other site 637910000052 trimer interface [polypeptide binding]; other site 637910000053 HMMPfam hit to PF00994, Molybdopterin binding, score 3.1e-30 637910000054 PS01078 Molybdenum cofactor biosynthesis proteins signature 1. 637910000055 metabolite-proton symporter; Region: 2A0106; TIGR00883 637910000056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910000057 putative substrate translocation pore; other site 637910000058 12 transmembrane helices predicted for ROD00081 by TMHMM2.0 at aa 21-43, 58-80, 93-115, 120-142, 151-173, 188-207, 242-264, 279-301, 308-330, 335-357, 370-392 and 397-417 637910000059 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.7e-26 637910000060 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000061 hypothetical protein; Provisional; Region: PRK10659 637910000062 HMMPfam hit to PF01184, GPR1/FUN34/yaaH, score 5e-122 637910000063 6 transmembrane helices predicted for ROD00091 by TMHMM2.0 at aa 12-34, 38-57, 64-86, 96-118, 125-144 and 148-170 637910000064 PS01114 GPR1/FUN34/yaaH family signature. 637910000065 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 637910000066 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 637910000067 nucleotide binding site [chemical binding]; other site 637910000068 HMMPfam hit to PF00012, Heat shock protein 70, score 0 637910000069 PS00297 Heat shock hsp70 proteins family signature 1. 637910000070 PS00329 Heat shock hsp70 proteins family signature 2. 637910000071 PS01036 Heat shock hsp70 proteins family signature 3. 637910000072 chaperone protein DnaJ; Provisional; Region: PRK10767 637910000073 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 637910000074 HSP70 interaction site [polypeptide binding]; other site 637910000075 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 637910000076 substrate binding site [polypeptide binding]; other site 637910000077 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 637910000078 Zn binding sites [ion binding]; other site 637910000079 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 637910000080 dimer interface [polypeptide binding]; other site 637910000081 HMMPfam hit to PF00226, Heat shock protein DnaJ, N-terminal, score 2.3e-40 637910000082 PS00636 Nt-dnaJ domain signature. 637910000083 HMMPfam hit to PF00684, DnaJ central region, score 4e-50 637910000084 PS00637 CXXCXGXG dnaJ domain signature. 637910000085 PS00190 Cytochrome c family heme-binding site signature. 637910000086 PS00190 Cytochrome c family heme-binding site signature. 637910000087 HMMPfam hit to PF01556, chaperone DnaJ, C-terminal, score 2.4e-75 637910000088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910000089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910000090 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 637910000091 dimerization interface [polypeptide binding]; other site 637910000092 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.2e-11 637910000093 Predicted helix-turn-helix motif with score 1048.000, SD 2.76 at aa 20-41, sequence GNVTKASKRLAVTPAAVSIALT 637910000094 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 637910000095 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 637910000096 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 637910000097 HMMPfam hit to PF05838, Protein of unknown function DUF847, score 1.6e-88 637910000098 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 637910000099 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 637910000100 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 637910000101 active site 637910000102 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 637910000103 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 637910000104 aromatic chitin/cellulose binding site residues [chemical binding]; other site 637910000105 HMMPfam hit to PF00704, Glycoside hydrolase, family 18, catalytic domain, score 1.1e-76 637910000106 PS00017 ATP/GTP-binding site motif A (P-loop). 637910000107 HMMPfam hit to PF02839, Carbohydrate-binding family V/XII, score 1.8e-06 637910000108 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 637910000109 HMMPfam hit to PF06965, Na+/H+ antiporter NhaA, score 2.2e-253 637910000110 11 transmembrane helices predicted for ROD00161 by TMHMM2.0 at aa 12-34, 59-76, 96-115, 125-147, 154-176, 180-202, 215-237, 257-279, 291-313, 328-350 and 357-379 637910000111 PS00044 Bacterial regulatory proteins, lysR family signature. 637910000112 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000113 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 637910000114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910000115 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 637910000116 putative dimerization interface [polypeptide binding]; other site 637910000117 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2.9e-17 637910000118 PS00044 Bacterial regulatory proteins, lysR family signature. 637910000119 HMMPfam hit to PF03466, LysR, substrate-binding, score 3.7e-05 637910000120 putative alpha-glucosidase; Provisional; Region: PRK10658 637910000121 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 637910000122 putative active site [active] 637910000123 putative catalytic site [active] 637910000124 HMMPfam hit to PF01055, Glycoside hydrolase, family 31, score 5.7e-168 637910000125 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 637910000126 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 637910000127 11 transmembrane helices predicted for ROD00191 by TMHMM2.0 at aa 42-64, 92-109, 124-146, 167-186, 191-213, 240-257, 277-299, 306-327, 332-354, 374-396 and 416-438 637910000128 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.8e-05 637910000129 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000130 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000131 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 637910000132 HMMPfam hit to PF01649, Ribosomal protein S20, score 9.9e-46 637910000133 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 637910000134 1 transmembrane helix predicted for ROD00213 by TMHMM2.0 at aa 27-49 637910000135 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 637910000136 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 637910000137 active site 637910000138 Riboflavin kinase; Region: Flavokinase; smart00904 637910000139 HMMPfam hit to PF06574, FAD synthetase, score 4.2e-87 637910000140 HMMPfam hit to PF01687, Riboflavin kinase, score 2e-63 637910000141 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 637910000142 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 637910000143 HIGH motif; other site 637910000144 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 637910000145 active site 637910000146 KMSKS motif; other site 637910000147 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 637910000148 tRNA binding surface [nucleotide binding]; other site 637910000149 anticodon binding site; other site 637910000150 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 637910000151 HMMPfam hit to PF00133, Aminoacyl-tRNA synthetase, class Ia, score 0 637910000152 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 637910000153 HMMPfam hit to PF08264, Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding, score 8.5e-58 637910000154 HMMPfam hit to PF06827, Formamidopyrimidine-DNA glycolase, C-terminal, score 2.5e-14 637910000155 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 637910000156 HMMPfam hit to PF01252, Peptidase A8, signal peptidase II, score 3.6e-84 637910000157 4 transmembrane helices predicted for ROD00241 by TMHMM2.0 at aa 13-35, 66-88, 100-122 and 137-159 637910000158 PS00855 Signal peptidases II signature. 637910000159 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 637910000160 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 637910000161 HMMPfam hit to PF00254, Peptidyl-prolyl cis-trans isomerase, FKBP-type, score 6.8e-13 637910000162 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 637910000163 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 637910000164 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 637910000165 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 637910000166 HMMPfam hit to PF02401, LytB protein, score 8.3e-189 637910000167 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 637910000168 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 637910000169 5 transmembrane helices predicted for ROD00281 by TMHMM2.0 at aa 110-132, 137-159, 185-207, 222-244 and 249-271 637910000170 HMMPfam hit to PF03613, Phosphotransferase system, mannose/fructose/sorbose family IID component, score 3.6e-95 637910000171 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910000172 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 637910000173 HMMPfam hit to PF03609, Phosphotransferase system, sorbose-specific IIC subunit, score 3.3e-16 637910000174 6 transmembrane helices predicted for ROD00291 by TMHMM2.0 at aa 10-32, 53-75, 97-119, 152-174, 179-201 and 213-235 637910000175 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 637910000176 active site 637910000177 phosphorylation site [posttranslational modification] 637910000178 HMMPfam hit to PF03830, Phosphotransferase system, sorbose subfamily IIB component, score 1.1e-15 637910000179 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 637910000180 active site 637910000181 active pocket/dimerization site; other site 637910000182 phosphorylation site [posttranslational modification] 637910000183 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 2.3e-17 637910000184 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 637910000185 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 637910000186 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637910000187 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910000188 DNA binding site [nucleotide binding] 637910000189 domain linker motif; other site 637910000190 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 637910000191 putative ligand binding site [chemical binding]; other site 637910000192 putative dimerization interface [polypeptide binding]; other site 637910000193 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 5e-09 637910000194 Predicted helix-turn-helix motif with score 2025.000, SD 6.08 at aa 4-25, sequence VTLAQVAKRAGVSTATVSMVLR 637910000195 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 2.5e-29 637910000196 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 637910000197 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 637910000198 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 637910000199 HMMPfam hit to PF01113, Dihydrodipicolinate reductase, score 9.9e-68 637910000200 HMMPfam hit to PF05173, Dihydrodipicolinate reductase, score 3.5e-80 637910000201 PS01298 Dihydrodipicolinate reductase signature. 637910000202 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 637910000203 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 637910000204 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 637910000205 catalytic site [active] 637910000206 subunit interface [polypeptide binding]; other site 637910000207 HMMPfam hit to PF00988, Carbamoyl-phosphate synthase, small chain, score 1.5e-95 637910000208 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 1.1e-75 637910000209 PS00442 Glutamine amidotransferases class-I active site. 637910000210 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 637910000211 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637910000212 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 637910000213 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 637910000214 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637910000215 ATP-grasp domain; Region: ATP-grasp_4; cl17255 637910000216 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 637910000217 IMP binding site; other site 637910000218 dimer interface [polypeptide binding]; other site 637910000219 interdomain contacts; other site 637910000220 partial ornithine binding site; other site 637910000221 HMMPfam hit to PF00289, Carbamoyl-phosphate synthetase large chain, N-terminal, score 4.3e-63 637910000222 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000223 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 1.9e-147 637910000224 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 637910000225 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 637910000226 HMMPfam hit to PF02787, Carbamoyl-phosphate synthetase large chain, oligomerisation, score 3.2e-68 637910000227 HMMPfam hit to PF00289, Carbamoyl-phosphate synthetase large chain, N-terminal, score 2.9e-26 637910000228 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 2.1e-18 637910000229 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 637910000230 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 2.5e-14 637910000231 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 637910000232 PS00017 ATP/GTP-binding site motif A (P-loop). 637910000233 HMMPfam hit to PF02142, MGS-like, score 7.4e-31 637910000234 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 637910000235 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 637910000236 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 637910000237 substrate binding site [chemical binding]; other site 637910000238 oxyanion hole (OAH) forming residues; other site 637910000239 trimer interface [polypeptide binding]; other site 637910000240 HMMPfam hit to PF00378, Crotonase, core, score 1.1e-78 637910000241 PS00166 Enoyl-CoA hydratase/isomerase signature. 637910000242 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910000243 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 637910000244 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 637910000245 acyl-activating enzyme (AAE) consensus motif; other site 637910000246 putative AMP binding site [chemical binding]; other site 637910000247 putative active site [active] 637910000248 putative CoA binding site [chemical binding]; other site 637910000249 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 5.8e-125 637910000250 PS00455 AMP-binding domain signature. 637910000251 PS00017 ATP/GTP-binding site motif A (P-loop). 637910000252 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 637910000253 CoA-transferase family III; Region: CoA_transf_3; pfam02515 637910000254 HMMPfam hit to PF02515, CoA-transferase family III, score 2.7e-97 637910000255 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 637910000256 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 637910000257 active site 637910000258 HMMPfam hit to PF00441, Acyl-CoA oxidase/dehydrogenase, type 1, score 9.4e-60 637910000259 PS00073 Acyl-CoA dehydrogenases signature 2. 637910000260 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase/oxidase, central region, score 1.4e-16 637910000261 PS00072 Acyl-CoA dehydrogenases signature 1. 637910000262 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal, score 4.7e-50 637910000263 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 637910000264 HMMPfam hit to PF02028, BCCT transporter score 8.2e-297 637910000265 12 transmembrane helices predicted for ROD00421 by TMHMM2.0 at aa 13-30, 50-72, 92-114, 141-163, 195-214, 229-251, 264-286, 312-334, 347-366, 410-432, 445-467 and 472-494 637910000266 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000267 PS01303 BCCT family of transporters signature. 637910000268 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000269 1 transmembrane helix predicted for ROD00431 by TMHMM2.0 at aa 24-43 637910000270 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 637910000271 Ligand binding site [chemical binding]; other site 637910000272 Electron transfer flavoprotein domain; Region: ETF; pfam01012 637910000273 HMMPfam hit to PF01012, Electron transfer flavoprotein, alpha/subunit beta, N-terminal, score 1.4e-58 637910000274 PS01065 Electron transfer flavoprotein subunit beta signature. 637910000275 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 637910000276 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 637910000277 Ligand binding site [chemical binding]; other site 637910000278 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 637910000279 HMMPfam hit to PF01012, Electron transfer flavoprotein, alpha/subunit beta, N-terminal, score 3.4e-38 637910000280 HMMPfam hit to PF00766, Electron transfer flavoprotein, subunit alpha, C-terminal, score 7e-42 637910000281 PS00696 Electron transfer flavoprotein alpha-subunit signature. 637910000282 putative oxidoreductase FixC; Provisional; Region: PRK10157 637910000283 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 4e-15 637910000284 ferredoxin-like protein FixX; Provisional; Region: PRK15449 637910000285 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637910000286 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637910000287 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637910000288 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.2e-27 637910000289 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 1.2e-17 637910000290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910000291 benzoate transport; Region: 2A0115; TIGR00895 637910000292 putative substrate translocation pore; other site 637910000293 12 transmembrane helices predicted for ROD00491 by TMHMM2.0 at aa 19-41, 54-76, 85-104, 109-131, 144-166, 171-193, 244-266, 281-303, 310-332, 336-358, 371-393 and 398-420 637910000294 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 8.9e-35 637910000295 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000296 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 637910000297 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 637910000298 HMMPfam hit to PF06004, Protein of unknown function DUF903, bacterial, score 1.2e-39 637910000299 1 transmembrane helix predicted for ROD00501 by TMHMM2.0 at aa 5-24 637910000300 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000301 autotransporter-associated beta strand repeat; Region: autotrns_rpt; TIGR02601 637910000302 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 637910000303 Autotransporter beta-domain; Region: Autotransporter; smart00869 637910000304 HMMPfam hit to PF03797, Autotransporter beta-domain, score 2.9e-24 637910000305 HMMPfam hit to PF03212, Pertactin, score 0.00051 637910000306 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 637910000307 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637910000308 HMMPfam hit to PF02525, Flavodoxin-like fold, score 2.9e-54 637910000309 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 637910000310 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 637910000311 TrkA-N domain; Region: TrkA_N; pfam02254 637910000312 13 transmembrane helices predicted for ROD00531 by TMHMM2.0 at aa 5-24, 26-45, 55-74, 86-108, 112-134, 147-169, 179-201, 214-233, 237-254, 267-289, 293-315, 327-349 and 359-381 637910000313 HMMPfam hit to PF00999, Sodium/hydrogen exchanger, score 3.6e-68 637910000314 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000315 HMMPfam hit to PF02254, TrkA-N, score 1.8e-34 637910000316 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 637910000317 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 637910000318 folate binding site [chemical binding]; other site 637910000319 NADP+ binding site [chemical binding]; other site 637910000320 HMMPfam hit to PF00186, Dihydrofolate reductase region, score 4.5e-59 637910000321 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910000322 PS00075 Dihydrofolate reductase signature. 637910000323 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 637910000324 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 637910000325 active site 637910000326 metal binding site [ion binding]; metal-binding site 637910000327 HMMPfam hit to PF00149, Metallophosphoesterase, score 5e-17 637910000328 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 637910000329 HMMPfam hit to PF04379, ApaG, score 8.2e-77 637910000330 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 637910000331 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 637910000332 HMMPfam hit to PF00398, Ribosomal RNA adenine methylase transferase, score 2e-108 637910000333 PS01131 Ribosomal RNA adenine dimethylases signature. 637910000334 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 637910000335 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 637910000336 HMMPfam hit to PF04166, Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA, score 4.7e-179 637910000337 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 637910000338 SurA N-terminal domain; Region: SurA_N; pfam09312 637910000339 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 637910000340 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 637910000341 HMMPfam hit to PF00639, Peptidyl-prolyl cis-trans isomerase, PpiC-type, score 2.3e-49 637910000342 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 637910000343 PS00017 ATP/GTP-binding site motif A (P-loop). 637910000344 HMMPfam hit to PF00639, Peptidyl-prolyl cis-trans isomerase, PpiC-type, score 1.7e-41 637910000345 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 637910000346 HMMPfam hit to PF09312, SurA N-terminal domain, score 2.1e-88 637910000347 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 637910000348 OstA-like protein; Region: OstA; pfam03968 637910000349 Organic solvent tolerance protein; Region: OstA_C; pfam04453 637910000350 HMMPfam hit to PF04453, Organic solvent tolerance protein, score 4.9e-150 637910000351 HMMPfam hit to PF03968, OstA-like protein, score 1.2e-66 637910000352 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 637910000353 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 637910000354 putative metal binding site [ion binding]; other site 637910000355 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 637910000356 HSP70 interaction site [polypeptide binding]; other site 637910000357 1 transmembrane helix predicted for ROD00621 by TMHMM2.0 at aa 7-29 637910000358 Predicted helix-turn-helix motif with score 1088.000, SD 2.89 at aa 152-173, sequence EVLYVIAEELGISRMQFEQFLR 637910000359 HMMPfam hit to PF00226, Heat shock protein DnaJ, N-terminal, score 2.3e-12 637910000360 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 637910000361 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 637910000362 active site 637910000363 HMMPfam hit to PF00849, Pseudouridine synthase, score 1.3e-59 637910000364 PS01129 Rlu family of pseudouridine synthase signature. 637910000365 ATP-dependent helicase HepA; Validated; Region: PRK04914 637910000366 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637910000367 ATP binding site [chemical binding]; other site 637910000368 putative Mg++ binding site [ion binding]; other site 637910000369 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637910000370 nucleotide binding region [chemical binding]; other site 637910000371 ATP-binding site [chemical binding]; other site 637910000372 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 3.2e-19 637910000373 HMMPfam hit to PF00176, SNF2-related, score 1.7e-86 637910000374 DNA polymerase II; Reviewed; Region: PRK05762 637910000375 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 637910000376 active site 637910000377 catalytic site [active] 637910000378 substrate binding site [chemical binding]; other site 637910000379 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 637910000380 active site 637910000381 metal-binding site 637910000382 HMMPfam hit to PF00136, DNA polymerase, B region, score 1e-30 637910000383 PS00116 DNA polymerase family B signature. 637910000384 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000385 HMMPfam hit to PF03104, DNA polymerase B, exonuclease, score 1.4e-54 637910000386 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 637910000387 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 637910000388 intersubunit interface [polypeptide binding]; other site 637910000389 active site 637910000390 Zn2+ binding site [ion binding]; other site 637910000391 HMMPfam hit to PF00596, Class II aldolase/adducin, N-terminal, score 6.9e-107 637910000392 L-arabinose isomerase; Provisional; Region: PRK02929 637910000393 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 637910000394 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 637910000395 trimer interface [polypeptide binding]; other site 637910000396 putative substrate binding site [chemical binding]; other site 637910000397 putative metal binding site [ion binding]; other site 637910000398 HMMPfam hit to PF02610, L-arabinose isomerase, score 0 637910000399 ribulokinase; Provisional; Region: PRK04123 637910000400 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 637910000401 N- and C-terminal domain interface [polypeptide binding]; other site 637910000402 active site 637910000403 MgATP binding site [chemical binding]; other site 637910000404 catalytic site [active] 637910000405 metal binding site [ion binding]; metal-binding site 637910000406 carbohydrate binding site [chemical binding]; other site 637910000407 homodimer interface [polypeptide binding]; other site 637910000408 HMMPfam hit to PF02782, Carbohydrate kinase, FGGY, score 2.4e-07 637910000409 HMMPfam hit to PF00370, Carbohydrate kinase, FGGY, score 1.2e-05 637910000410 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 637910000411 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 637910000412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910000413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910000414 HMMPfam hit to PF02311, AraC protein, arabinose-binding/dimerisation, score 1.1e-28 637910000415 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.6e-11 637910000416 Predicted helix-turn-helix motif with score 1779.000, SD 5.25 at aa 195-216, sequence FDIASVAQHVCLSPSRLSHLFR 637910000417 PS00041 Bacterial regulatory proteins, araC family signature. 637910000418 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 4.8e-12 637910000419 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 637910000420 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 637910000421 5 transmembrane helices predicted for ROD00721 by TMHMM2.0 at aa 20-42, 57-79, 140-162, 177-199 and 219-241 637910000422 HMMPfam hit to PF09335, SNARE associated Golgi protein, score 7.2e-05 637910000423 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000424 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 637910000425 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 637910000426 Walker A/P-loop; other site 637910000427 ATP binding site [chemical binding]; other site 637910000428 Q-loop/lid; other site 637910000429 ABC transporter signature motif; other site 637910000430 Walker B; other site 637910000431 D-loop; other site 637910000432 H-loop/switch region; other site 637910000433 HMMPfam hit to PF00005, ABC transporter related, score 4e-63 637910000434 PS00211 ABC transporters family signature. 637910000435 PS00017 ATP/GTP-binding site motif A (P-loop). 637910000436 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 637910000437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910000438 dimer interface [polypeptide binding]; other site 637910000439 conserved gate region; other site 637910000440 putative PBP binding loops; other site 637910000441 ABC-ATPase subunit interface; other site 637910000442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910000443 dimer interface [polypeptide binding]; other site 637910000444 conserved gate region; other site 637910000445 putative PBP binding loops; other site 637910000446 ABC-ATPase subunit interface; other site 637910000447 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 0.00049 637910000448 12 transmembrane helices predicted for ROD00741 by TMHMM2.0 at aa 13-35, 55-77, 90-112, 127-149, 199-221, 241-260, 293-315, 335-357, 370-392, 407-424, 462-484 and 508-525 637910000449 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 6.2e-07 637910000450 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 637910000451 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 637910000452 transcriptional regulator SgrR; Provisional; Region: PRK13626 637910000453 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 637910000454 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 637910000455 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 1.1e-48 637910000456 Predicted helix-turn-helix motif with score 1534.000, SD 4.41 at aa 24-45, sequence TTLNELAELLNCSRRHMRTLLN 637910000457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910000458 sugar efflux transporter; Region: 2A0120; TIGR00899 637910000459 putative substrate translocation pore; other site 637910000460 12 transmembrane helices predicted for ROD00781 by TMHMM2.0 at aa 11-33, 48-70, 82-99, 104-126, 150-172, 176-198, 220-242, 252-274, 283-302, 307-329, 342-364 and 369-387 637910000461 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 6.9e-27 637910000462 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 637910000463 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 637910000464 substrate binding site [chemical binding]; other site 637910000465 HMMPfam hit to PF00694, Aconitase A/isopropylmalate dehydratase small subunit, swivel, score 1.3e-66 637910000466 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 637910000467 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 637910000468 substrate binding site [chemical binding]; other site 637910000469 ligand binding site [chemical binding]; other site 637910000470 HMMPfam hit to PF00330, Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, score 5.7e-290 637910000471 PS01244 Aconitase family signature 2. 637910000472 PS00450 Aconitase family signature 1. 637910000473 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 637910000474 tartrate dehydrogenase; Region: TTC; TIGR02089 637910000475 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 2.1e-227 637910000476 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 637910000477 2-isopropylmalate synthase; Validated; Region: PRK00915 637910000478 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 637910000479 active site 637910000480 catalytic residues [active] 637910000481 metal binding site [ion binding]; metal-binding site 637910000482 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 637910000483 HMMPfam hit to PF08502, LeuA allosteric (dimerisation) domain, score 4e-63 637910000484 HMMPfam hit to PF00682, Pyruvate carboxyltransferase, score 2.8e-150 637910000485 PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. 637910000486 PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 637910000487 Leucine operon leader peptide; Region: Leu_leader; cl15436 637910000488 HMMPfam hit to PF08054, Leucine operon leader peptide, score 5.8e-11 637910000489 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 637910000490 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910000491 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 637910000492 putative substrate binding pocket [chemical binding]; other site 637910000493 putative dimerization interface [polypeptide binding]; other site 637910000494 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 4.4e-20 637910000495 Predicted helix-turn-helix motif with score 1896.000, SD 5.64 at aa 39-60, sequence QNITRAAHALGMSQPAVSNAVA 637910000496 PS00044 Bacterial regulatory proteins, lysR family signature. 637910000497 HMMPfam hit to PF03466, LysR, substrate-binding, score 3.5e-07 637910000498 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910000499 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 637910000500 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 637910000501 PYR/PP interface [polypeptide binding]; other site 637910000502 dimer interface [polypeptide binding]; other site 637910000503 TPP binding site [chemical binding]; other site 637910000504 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637910000505 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 637910000506 TPP-binding site [chemical binding]; other site 637910000507 dimer interface [polypeptide binding]; other site 637910000508 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-terminal TPP binding region, score 2.3e-103 637910000509 PS00044 Bacterial regulatory proteins, lysR family signature. 637910000510 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central region, score 1.6e-67 637910000511 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000512 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-terminal TPP-binding, score 5.1e-80 637910000513 PS00187 Thiamine pyrophosphate enzymes signature. 637910000514 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 637910000515 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 637910000516 putative valine binding site [chemical binding]; other site 637910000517 dimer interface [polypeptide binding]; other site 637910000518 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 637910000519 PS00430 TonB-dependent receptor proteins signature 1. 637910000520 HMMPfam hit to PF01842, Amino acid-binding ACT, score 1.6e-13 637910000521 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 637910000522 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910000523 DNA binding site [nucleotide binding] 637910000524 domain linker motif; other site 637910000525 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 637910000526 dimerization interface [polypeptide binding]; other site 637910000527 ligand binding site [chemical binding]; other site 637910000528 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 3.6e-10 637910000529 Predicted helix-turn-helix motif with score 1821.000, SD 5.39 at aa 1-22, sequence MKLDEIARLAGVSRTTASYVIN 637910000530 PS00356 Bacterial regulatory proteins, lacI family signature. 637910000531 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 5.7e-07 637910000532 MraZ protein; Region: MraZ; pfam02381 637910000533 MraZ protein; Region: MraZ; pfam02381 637910000534 HMMPfam hit to PF02381, MraZ, score 4.1e-09 637910000535 HMMPfam hit to PF02381, MraZ, score 8.8e-24 637910000536 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 637910000537 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 637910000538 HMMPfam hit to PF01795, Bacterial methyltransferase, score 1.2e-191 637910000539 cell division protein FtsL; Provisional; Region: PRK10772 637910000540 HMMPfam hit to PF04999, Cell division protein FtsL, score 1.3e-65 637910000541 1 transmembrane helix predicted for ROD00891 by TMHMM2.0 at aa 35-57 637910000542 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 637910000543 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637910000544 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 637910000545 1 transmembrane helix predicted for ROD00901 by TMHMM2.0 at aa 20-42 637910000546 HMMPfam hit to PF03717, Penicillin-binding protein, dimerisation domain, score 9.8e-67 637910000547 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 9.1e-120 637910000548 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 637910000549 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637910000550 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637910000551 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637910000552 HMMPfam hit to PF01225, Mur ligase, N-terminal, score 6.6e-17 637910000553 HMMPfam hit to PF08245, Mur ligase, central, score 4.4e-74 637910000554 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 1.9e-39 637910000555 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 637910000556 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637910000557 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637910000558 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637910000559 HMMPfam hit to PF01225, Mur ligase, N-terminal, score 1.2e-22 637910000560 HMMPfam hit to PF08245, Mur ligase, central, score 4.3e-70 637910000561 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 1.9e-19 637910000562 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 637910000563 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 637910000564 Mg++ binding site [ion binding]; other site 637910000565 putative catalytic motif [active] 637910000566 putative substrate binding site [chemical binding]; other site 637910000567 10 transmembrane helices predicted for ROD00931 by TMHMM2.0 at aa 15-37, 75-92, 97-114, 134-151, 171-193, 200-219, 234-256, 263-285, 289-311 and 338-357 637910000568 HMMPfam hit to PF00953, Glycosyl transferase, family 4, score 2.1e-87 637910000569 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 637910000570 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637910000571 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637910000572 1 transmembrane helix predicted for ROD00941 by TMHMM2.0 at aa 9-31 637910000573 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000574 HMMPfam hit to PF08245, Mur ligase, central, score 1.6e-60 637910000575 PS00012 Phosphopantetheine attachment site. 637910000576 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 1.2e-12 637910000577 cell division protein FtsW; Provisional; Region: PRK10774 637910000578 10 transmembrane helices predicted for ROD00951 by TMHMM2.0 at aa 13-32, 47-66, 87-104, 114-136, 175-194, 198-217, 222-244, 307-329, 341-363 and 373-395 637910000579 HMMPfam hit to PF01098, Cell cycle protein, score 6.7e-186 637910000580 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 637910000581 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 637910000582 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 637910000583 active site 637910000584 homodimer interface [polypeptide binding]; other site 637910000585 HMMPfam hit to PF03033, Glycosyl transferase, family 28, score 2.7e-54 637910000586 HMMPfam hit to PF04101, Glycosyltransferase 28, C-terminal, score 1.3e-53 637910000587 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 637910000588 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637910000589 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637910000590 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637910000591 HMMPfam hit to PF01225, Mur ligase, N-terminal, score 1.2e-47 637910000592 HMMPfam hit to PF08245, Mur ligase, central, score 2.1e-34 637910000593 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 4.5e-22 637910000594 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 637910000595 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 637910000596 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 637910000597 HMMPfam hit to PF01820, D-alanine--D-alanine ligase, N-terminal, score 5.6e-55 637910000598 PS00843 D-alanine--D-alanine ligase signature 1. 637910000599 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 637910000600 HMMPfam hit to PF07478, D-alanine--D-alanine ligase, C-terminal, score 5.4e-109 637910000601 PS00844 D-alanine--D-alanine ligase signature 2. 637910000602 cell division protein FtsQ; Provisional; Region: PRK10775 637910000603 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 637910000604 Cell division protein FtsQ; Region: FtsQ; pfam03799 637910000605 1 transmembrane helix predicted for ROD00991 by TMHMM2.0 at aa 26-48 637910000606 HMMPfam hit to PF08478, Polypeptide-transport-associated, FtsQ-type, score 9.8e-25 637910000607 HMMPfam hit to PF03799, Cell division protein FtsQ, score 1.8e-35 637910000608 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 637910000609 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637910000610 Cell division protein FtsA; Region: FtsA; pfam14450 637910000611 HMMPfam hit to PF02491, Cell division protein FtsA, score 3e-79 637910000612 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000613 HMMPfam hit to PF02491, Cell division protein FtsA, score 2.1e-79 637910000614 cell division protein FtsZ; Validated; Region: PRK09330 637910000615 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 637910000616 nucleotide binding site [chemical binding]; other site 637910000617 SulA interaction site; other site 637910000618 HMMPfam hit to PF00091, Tubulin/FtsZ, GTPase, score 1.8e-93 637910000619 PS01134 FtsZ protein signature 1. 637910000620 PS01135 FtsZ protein signature 2. 637910000621 HMMPfam hit to PF03953, Tubulin/FtsZ, C-terminal, score 2.1e-44 637910000622 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 637910000623 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 637910000624 HMMPfam hit to PF03331, UDP-3-O-acyl N-acetylglucosamine deacetylase, score 2.9e-193 637910000625 SecA regulator SecM; Provisional; Region: PRK02943 637910000626 1 transmembrane helix predicted for ROD01031 by TMHMM2.0 at aa 31-53 637910000627 HMMPfam hit to PF06558, Secretion monitor, score 5.9e-95 637910000628 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 637910000629 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 637910000630 SEC-C motif; Region: SEC-C; pfam02810 637910000631 HMMPfam hit to PF07517, SecA DEAD-like, score 1e-216 637910000632 HMMPfam hit to PF01043, SecA preprotein cross-linking region, score 1.9e-83 637910000633 PS01312 Protein secA signatures. 637910000634 Predicted helix-turn-helix motif with score 1222.000, SD 3.35 at aa 518-539, sequence SWQAEIAALENPTPEQIAQIKA 637910000635 HMMPfam hit to PF07516, SecA Wing and Scaffold, score 5.2e-124 637910000636 HMMPfam hit to PF02810, SEC-C motif, score 2.8e-11 637910000637 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 637910000638 active site 637910000639 8-oxo-dGMP binding site [chemical binding]; other site 637910000640 nudix motif; other site 637910000641 metal binding site [ion binding]; metal-binding site 637910000642 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 3.8e-30 637910000643 PS00893 mutT domain signature. 637910000644 DNA gyrase inhibitor; Reviewed; Region: PRK00418 637910000645 HMMPfam hit to PF03884, Protein of unknown function DUF329, score 7.8e-42 637910000646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 637910000647 HMMPfam hit to PF07072, Protein of unknown function DUF1342, score 4.1e-164 637910000648 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 637910000649 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 637910000650 CoA-binding site [chemical binding]; other site 637910000651 ATP-binding [chemical binding]; other site 637910000652 HMMPfam hit to PF01121, Dephospho-CoA kinase, score 2e-103 637910000653 PS01294 Uncharacterized protein family UPF0038 signature. 637910000654 PS00017 ATP/GTP-binding site motif A (P-loop). 637910000655 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 637910000656 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 637910000657 active site 637910000658 HMMPfam hit to PF00478, IMP dehydrogenase/GMP reductase, score 1.2e-159 637910000659 PS00487 IMP dehydrogenase / GMP reductase signature. 637910000660 type IV pilin biogenesis protein; Provisional; Region: PRK10573 637910000661 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 637910000662 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 637910000663 3 transmembrane helices predicted for ROD01101 by TMHMM2.0 at aa 163-185, 216-238 and 368-390 637910000664 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 1.5e-14 637910000665 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 9.9e-22 637910000666 PS00874 Bacterial type II secretion system protein F signature. 637910000667 hypothetical protein; Provisional; Region: PRK10436 637910000668 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 637910000669 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 637910000670 Walker A motif; other site 637910000671 ATP binding site [chemical binding]; other site 637910000672 Walker B motif; other site 637910000673 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 3.4e-129 637910000674 PS00662 Bacterial type II secretion system protein E signature. 637910000675 PS00017 ATP/GTP-binding site motif A (P-loop). 637910000676 putative major pilin subunit; Provisional; Region: PRK10574 637910000677 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 637910000678 Pilin (bacterial filament); Region: Pilin; pfam00114 637910000679 1 transmembrane helix predicted for ROD01121 by TMHMM2.0 at aa 7-29 637910000680 HMMPfam hit to PF07963, Prepilin-type cleavage/methylation, N-terminal, score 1.9e-08 637910000681 PS00409 Prokaryotic N-terminal methylation site. 637910000682 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 637910000683 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 637910000684 dimerization interface [polypeptide binding]; other site 637910000685 active site 637910000686 HMMPfam hit to PF01729, Quinolinate phosphoribosyl transferase, score 3.2e-99 637910000687 HMMPfam hit to PF02749, Quinolinate phosphoribosyl transferase, score 1.4e-42 637910000688 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 637910000689 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 637910000690 amidase catalytic site [active] 637910000691 Zn binding residues [ion binding]; other site 637910000692 substrate binding site [chemical binding]; other site 637910000693 HMMPfam hit to PF01510, N-acetylmuramoyl-L-alanine amidase, family 2, score 5.7e-60 637910000694 regulatory protein AmpE; Provisional; Region: PRK10987 637910000695 4 transmembrane helices predicted for ROD01151 by TMHMM2.0 at aa 39-58, 63-85, 146-168 and 266-283 637910000696 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 637910000697 active site 637910000698 HMMPfam hit to PF04616, Glycoside hydrolase, family 43, score 2.4e-127 637910000699 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 637910000700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910000701 putative substrate translocation pore; other site 637910000702 12 transmembrane helices predicted for ROD01171 by TMHMM2.0 at aa 12-34, 39-61, 82-99, 109-131, 152-174, 184-201, 234-256, 266-288, 295-317, 322-344, 365-387 and 407-429 637910000703 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.9e-10 637910000704 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000705 aromatic amino acid transporter; Provisional; Region: PRK10238 637910000706 HMMPfam hit to PF00324, Amino acid permease-associated region, score 1.1e-176 637910000707 12 transmembrane helices predicted for ROD01181 by TMHMM2.0 at aa 20-42, 47-66, 87-109, 119-141, 154-176, 199-221, 241-263, 283-305, 332-354, 358-380, 400-422 and 427-446 637910000708 PS00218 Amino acid permeases signature. 637910000709 Transcriptional regulators [Transcription]; Region: FadR; COG2186 637910000710 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910000711 DNA-binding site [nucleotide binding]; DNA binding site 637910000712 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 637910000713 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 3.9e-34 637910000714 PS00043 Bacterial regulatory proteins, gntR family signature. 637910000715 Predicted helix-turn-helix motif with score 1327.000, SD 3.71 at aa 35-56, sequence PPERELAKQFDVSRPSLREAIQ 637910000716 HMMPfam hit to PF07729, GntR, C-terminal, score 2.6e-32 637910000717 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 637910000718 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 637910000719 dimer interface [polypeptide binding]; other site 637910000720 TPP-binding site [chemical binding]; other site 637910000721 HMMPfam hit to PF00456, Transketolase, N-terminal, score 7e-05 637910000722 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 637910000723 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 637910000724 E3 interaction surface; other site 637910000725 lipoyl attachment site [posttranslational modification]; other site 637910000726 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 637910000727 E3 interaction surface; other site 637910000728 lipoyl attachment site [posttranslational modification]; other site 637910000729 e3 binding domain; Region: E3_binding; pfam02817 637910000730 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 637910000731 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 2.5e-28 637910000732 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 637910000733 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 3.9e-28 637910000734 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 637910000735 PS00017 ATP/GTP-binding site motif A (P-loop). 637910000736 HMMPfam hit to PF02817, E3 binding, score 2e-18 637910000737 HMMPfam hit to PF00198, Catalytic domain of components of various dehydrogenase complexes, score 6.5e-111 637910000738 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 637910000739 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 637910000740 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637910000741 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637910000742 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 1.1e-76 637910000743 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 637910000744 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 1.3e-24 637910000745 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 2.5e-52 637910000746 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 637910000747 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 637910000748 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 637910000749 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 637910000750 substrate binding site [chemical binding]; other site 637910000751 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 637910000752 substrate binding site [chemical binding]; other site 637910000753 ligand binding site [chemical binding]; other site 637910000754 HMMPfam hit to PF06434, Aconitase B, N-terminal, bacterial, score 4.1e-290 637910000755 HMMPfam hit to PF00330, Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, score 6.4e-11 637910000756 PS00450 Aconitase family signature 1. 637910000757 PS01244 Aconitase family signature 2. 637910000758 hypothetical protein; Provisional; Region: PRK05248 637910000759 HMMPfam hit to PF06062, Uncharacterised conserved protein UCP006287, score 1.5e-74 637910000760 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 637910000761 HMMPfam hit to PF03812, 2-keto-3-deoxygluconate permease, score 1.3e-96 637910000762 10 transmembrane helices predicted for ROD01271 by TMHMM2.0 at aa 13-35, 45-64, 71-90, 100-122, 134-156, 160-182, 189-211, 215-237, 244-266 and 281-303 637910000763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 637910000764 HMMPfam hit to PF07005, type III effector Hrp-dependent outers, score 4.9e-06 637910000765 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 637910000766 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 637910000767 HMMPfam hit to PF04166, Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA, score 1.5e-115 637910000768 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000769 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637910000770 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 637910000771 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637910000772 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 5.9e-18 637910000773 PS00894 Bacterial regulatory proteins, deoR family signature. 637910000774 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 1.2e-48 637910000775 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 637910000776 HMMPfam hit to PF02675, S-adenosylmethionine decarboxylase related, score 2.1e-78 637910000777 spermidine synthase; Provisional; Region: PRK00811 637910000778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910000779 S-adenosylmethionine binding site [chemical binding]; other site 637910000780 HMMPfam hit to PF01564, Spermine synthase, score 1.1e-133 637910000781 PS00136 Serine proteases, subtilase family, aspartic acid active site. 637910000782 PS01330 Spermidine/spermine synthases family signature. 637910000783 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 637910000784 multicopper oxidase; Provisional; Region: PRK10965 637910000785 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 637910000786 Multicopper oxidase; Region: Cu-oxidase; pfam00394 637910000787 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 637910000788 HMMPfam hit to PF07732, Multicopper oxidase, type 3, score 4.1e-47 637910000789 HMMPfam hit to PF07731, Multicopper oxidase, type 2, score 3e-20 637910000790 PS00080 Multicopper oxidases signature 2. 637910000791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637910000792 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637910000793 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637910000794 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 2.7e-31 637910000795 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 637910000796 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 637910000797 Trp docking motif [polypeptide binding]; other site 637910000798 putative active site [active] 637910000799 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 2.2e-08 637910000800 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 4.3e-06 637910000801 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 0.00093 637910000802 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 0.0021 637910000803 PS00364 Bacterial quinoprotein dehydrogenases signature 2. 637910000804 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 0.0004 637910000805 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 5.3e-05 637910000806 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 3e-08 637910000807 PS00363 Bacterial quinoprotein dehydrogenases signature 1. 637910000808 5 transmembrane helices predicted for ROD01361 by TMHMM2.0 at aa 13-35, 40-57, 64-81, 96-113 and 120-139 637910000809 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637910000810 active site 637910000811 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 9.1e-38 637910000812 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 637910000813 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 637910000814 active site clefts [active] 637910000815 zinc binding site [ion binding]; other site 637910000816 dimer interface [polypeptide binding]; other site 637910000817 HMMPfam hit to PF00484, Carbonic anhydrase, score 2.5e-62 637910000818 PS00705 Prokaryotic-type carbonic anhydrases signature 2. 637910000819 PS00704 Prokaryotic-type carbonic anhydrases signature 1. 637910000820 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637910000821 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 637910000822 Walker A/P-loop; other site 637910000823 ATP binding site [chemical binding]; other site 637910000824 Q-loop/lid; other site 637910000825 ABC transporter signature motif; other site 637910000826 Walker B; other site 637910000827 D-loop; other site 637910000828 H-loop/switch region; other site 637910000829 HMMPfam hit to PF00005, ABC transporter related, score 3.5e-53 637910000830 PS00017 ATP/GTP-binding site motif A (P-loop). 637910000831 PS00211 ABC transporters family signature. 637910000832 inner membrane transport permease; Provisional; Region: PRK15066 637910000833 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 637910000834 HMMPfam hit to PF01061, ABC-2 type transporter score 2.3e-48 637910000835 6 transmembrane helices predicted for ROD01401 by TMHMM2.0 at aa 20-42, 62-84, 104-126, 141-163, 170-192 and 226-248 637910000836 PS00890 ABC-2 type transport system integral membrane proteins signature. 637910000837 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 637910000838 active pocket/dimerization site; other site 637910000839 active site 637910000840 phosphorylation site [posttranslational modification] 637910000841 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 2e-26 637910000842 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 637910000843 putative active site [active] 637910000844 putative metal binding site [ion binding]; other site 637910000845 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 6.1e-23 637910000846 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910000847 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 637910000848 tetramerization interface [polypeptide binding]; other site 637910000849 active site 637910000850 HMMPfam hit to PF02261, Aspartate decarboxylase, score 2e-84 637910000851 PS00678 Trp-Asp (WD) repeats signature. 637910000852 pantoate--beta-alanine ligase; Region: panC; TIGR00018 637910000853 Pantoate-beta-alanine ligase; Region: PanC; cd00560 637910000854 active site 637910000855 ATP-binding site [chemical binding]; other site 637910000856 pantoate-binding site; other site 637910000857 HXXH motif; other site 637910000858 HMMPfam hit to PF02569, Pantoate-beta-alanine ligase, score 5.8e-172 637910000859 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 637910000860 active site 637910000861 oligomerization interface [polypeptide binding]; other site 637910000862 metal binding site [ion binding]; metal-binding site 637910000863 HMMPfam hit to PF02548, Ketopantoate hydroxymethyltransferase, score 2.8e-168 637910000864 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 637910000865 catalytic center binding site [active] 637910000866 ATP binding site [chemical binding]; other site 637910000867 HMMPfam hit to PF01288, 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK, score 1e-74 637910000868 PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. 637910000869 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 637910000870 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 637910000871 active site 637910000872 NTP binding site [chemical binding]; other site 637910000873 metal binding triad [ion binding]; metal-binding site 637910000874 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 637910000875 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 637910000876 HMMPfam hit to PF01743, Polynucleotide adenylyltransferase region, score 6.2e-74 637910000877 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 637910000878 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 637910000879 active site 637910000880 nucleotide binding site [chemical binding]; other site 637910000881 HIGH motif; other site 637910000882 KMSKS motif; other site 637910000883 PS00092 N-6 Adenine-specific DNA methylases signature. 637910000884 HMMPfam hit to PF00749, Glutamyl/glutaminyl-tRNA synthetase, class Ic, score 7.7e-29 637910000885 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 637910000886 HMMPfam hit to PF01258, Zinc finger, DksA/TraR C4-type, score 3.4e-36 637910000887 PS01102 Prokaryotic dksA/traR C4-type zinc finger. 637910000888 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 637910000889 HMMPfam hit to PF03749, Sugar fermentation stimulation protein, score 2e-106 637910000890 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000891 2'-5' RNA ligase; Provisional; Region: PRK15124 637910000892 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 637910000893 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 637910000894 HMMPfam hit to PF02834, Phosphoesterase, HXTX, score 2.5e-10 637910000895 HMMPfam hit to PF02834, Phosphoesterase, HXTX, score 2.6e-20 637910000896 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 637910000897 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637910000898 ATP binding site [chemical binding]; other site 637910000899 putative Mg++ binding site [ion binding]; other site 637910000900 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637910000901 nucleotide binding region [chemical binding]; other site 637910000902 ATP-binding site [chemical binding]; other site 637910000903 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 637910000904 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 637910000905 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 3.3e-07 637910000906 PS00017 ATP/GTP-binding site motif A (P-loop). 637910000907 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 7.1e-12 637910000908 HMMPfam hit to PF04408, Helicase-associated region, score 1.1e-09 637910000909 HMMPfam hit to PF08482, RNA helicase, ATP-dependent, HrpB type, C-terminal, score 3.7e-92 637910000910 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 637910000911 Transglycosylase; Region: Transgly; pfam00912 637910000912 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 637910000913 1 transmembrane helix predicted for ROD01531 by TMHMM2.0 at aa 64-86 637910000914 HMMPfam hit to PF00912, Glycosyl transferase, family 51, score 1.7e-83 637910000915 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 1.2e-19 637910000916 PS00017 ATP/GTP-binding site motif A (P-loop). 637910000917 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 637910000918 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637910000919 N-terminal plug; other site 637910000920 ligand-binding site [chemical binding]; other site 637910000921 PS00430 TonB-dependent receptor proteins signature 1. 637910000922 HMMPfam hit to PF07715, TonB-dependent receptor, plug, score 1.7e-21 637910000923 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 6e-27 637910000924 PS01156 TonB-dependent receptor proteins signature 2. 637910000925 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 637910000926 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637910000927 Walker A/P-loop; other site 637910000928 ATP binding site [chemical binding]; other site 637910000929 Q-loop/lid; other site 637910000930 ABC transporter signature motif; other site 637910000931 Walker B; other site 637910000932 D-loop; other site 637910000933 H-loop/switch region; other site 637910000934 HMMPfam hit to PF00005, ABC transporter related, score 8.5e-59 637910000935 PS00017 ATP/GTP-binding site motif A (P-loop). 637910000936 PS00211 ABC transporters family signature. 637910000937 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 637910000938 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 637910000939 siderophore binding site; other site 637910000940 HMMPfam hit to PF01497, Periplasmic binding protein, score 4.6e-11 637910000941 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910000942 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 637910000943 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637910000944 ABC-ATPase subunit interface; other site 637910000945 dimer interface [polypeptide binding]; other site 637910000946 putative PBP binding regions; other site 637910000947 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637910000948 ABC-ATPase subunit interface; other site 637910000949 dimer interface [polypeptide binding]; other site 637910000950 putative PBP binding regions; other site 637910000951 16 transmembrane helices predicted for ROD01571 by TMHMM2.0 at aa 5-27, 57-79, 92-111, 115-137, 144-166, 238-260, 273-291, 301-323, 347-369, 389-411, 424-442, 446-468, 480-499, 567-589, 601-623 and 633-655 637910000952 HMMPfam hit to PF01032, Bacterial transport system permease, score 1.5e-42 637910000953 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000954 HMMPfam hit to PF01032, Bacterial transport system permease, score 1.3e-62 637910000955 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000956 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 637910000957 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 637910000958 inhibitor-cofactor binding pocket; inhibition site 637910000959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910000960 catalytic residue [active] 637910000961 HMMPfam hit to PF00202, Aminotransferase class-III, score 1.6e-92 637910000962 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000963 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 637910000964 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 637910000965 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 637910000966 Cl- selectivity filter; other site 637910000967 Cl- binding residues [ion binding]; other site 637910000968 pore gating glutamate residue; other site 637910000969 dimer interface [polypeptide binding]; other site 637910000970 H+/Cl- coupling transport residue; other site 637910000971 11 transmembrane helices predicted for ROD01591 by TMHMM2.0 at aa 31-53, 75-97, 124-146, 179-201, 210-232, 252-274, 287-309, 319-341, 354-376, 391-413 and 418-440 637910000972 HMMPfam hit to PF00654, Chloride channel, core, score 8e-119 637910000973 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910000974 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 637910000975 HMMPfam hit to PF01521, HesB/YadR/YfhF, score 2.6e-42 637910000976 PS01152 Hypothetical hesB/yadR/yfhF family signature. 637910000977 hypothetical protein; Provisional; Region: PRK10578 637910000978 UPF0126 domain; Region: UPF0126; pfam03458 637910000979 UPF0126 domain; Region: UPF0126; pfam03458 637910000980 HMMPfam hit to PF03458, Protein of unknown function UPF0126, score 7.3e-32 637910000981 6 transmembrane helices predicted for ROD01611 by TMHMM2.0 at aa 4-23, 30-47, 62-79, 88-106, 116-138 and 150-172 637910000982 HMMPfam hit to PF03458, Protein of unknown function UPF0126, score 5.4e-39 637910000983 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 637910000984 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 637910000985 cobalamin binding residues [chemical binding]; other site 637910000986 putative BtuC binding residues; other site 637910000987 dimer interface [polypeptide binding]; other site 637910000988 HMMPfam hit to PF01497, Periplasmic binding protein, score 1.5e-46 637910000989 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 637910000990 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 637910000991 HMMPfam hit to PF01048, Nucleoside phosphorylase, score 4.3e-110 637910000992 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 637910000993 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637910000994 Zn2+ binding site [ion binding]; other site 637910000995 Mg2+ binding site [ion binding]; other site 637910000996 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 637910000997 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 2.8e-09 637910000998 serine endoprotease; Provisional; Region: PRK10942 637910000999 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 637910001000 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 637910001001 protein binding site [polypeptide binding]; other site 637910001002 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 637910001003 HMMPfam hit to PF00089, Peptidase S1 and S6, chymotrypsin/Hap, score 2.4e-34 637910001004 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 3.2e-22 637910001005 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 2e-16 637910001006 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 637910001007 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 637910001008 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 637910001009 HMMPfam hit to PF05651, sugar diacid recognition, score 1e-170 637910001010 Predicted helix-turn-helix motif with score 1014.000, SD 2.64 at aa 311-332, sequence LTRLKAMDNNGLLRRTLTAWFR 637910001011 hypothetical protein; Provisional; Region: PRK13677 637910001012 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 637910001013 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 637910001014 trimer interface [polypeptide binding]; other site 637910001015 active site 637910001016 substrate binding site [chemical binding]; other site 637910001017 CoA binding site [chemical binding]; other site 637910001018 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 2.7 637910001019 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 2 637910001020 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.82 637910001021 PS00101 Hexapeptide-repeat containing-transferases signature. 637910001022 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 30 637910001023 PII uridylyl-transferase; Provisional; Region: PRK05007 637910001024 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 637910001025 metal binding triad; other site 637910001026 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 637910001027 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637910001028 Zn2+ binding site [ion binding]; other site 637910001029 Mg2+ binding site [ion binding]; other site 637910001030 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 637910001031 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 637910001032 HMMPfam hit to PF01842, Amino acid-binding ACT, score 8.4e-10 637910001033 HMMPfam hit to PF01842, Amino acid-binding ACT, score 3.2e-06 637910001034 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 2.5e-21 637910001035 HMMPfam hit to PF08335, GlnD PII-uridylyltransferase, score 4.6e-117 637910001036 HMMPfam hit to PF01909, DNA polymerase, beta-like region, score 1.5e-12 637910001037 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 637910001038 active site 637910001039 HMMPfam hit to PF00557, Peptidase M24, catalytic core, score 2.5e-106 637910001040 PS00680 Methionine aminopeptidase subfamily 1 signature. 637910001041 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 637910001042 rRNA interaction site [nucleotide binding]; other site 637910001043 S8 interaction site; other site 637910001044 putative laminin-1 binding site; other site 637910001045 PS00962 Ribosomal protein S2 signature 1. 637910001046 HMMPfam hit to PF00318, Ribosomal protein S2, score 6.5e-131 637910001047 PS00963 Ribosomal protein S2 signature 2. 637910001048 elongation factor Ts; Provisional; Region: tsf; PRK09377 637910001049 UBA/TS-N domain; Region: UBA; pfam00627 637910001050 Elongation factor TS; Region: EF_TS; pfam00889 637910001051 Elongation factor TS; Region: EF_TS; pfam00889 637910001052 HMMPfam hit to PF00627, Ubiquitin-associated_translation elongation factor EF1B, N-terminal, score 6.2e-13 637910001053 PS01126 Elongation factor Ts signature 1. 637910001054 HMMPfam hit to PF00889, Translation elongation factor EFTs/EF1B, dimerisation, score 2.8e-107 637910001055 PS01127 Elongation factor Ts signature 2. 637910001056 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 637910001057 putative nucleotide binding site [chemical binding]; other site 637910001058 uridine monophosphate binding site [chemical binding]; other site 637910001059 homohexameric interface [polypeptide binding]; other site 637910001060 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 2.6e-63 637910001061 ribosome recycling factor; Reviewed; Region: frr; PRK00083 637910001062 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 637910001063 hinge region; other site 637910001064 HMMPfam hit to PF01765, Ribosome recycling factor, score 1.9e-101 637910001065 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 637910001066 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 637910001067 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 637910001068 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 637910001069 HMMPfam hit to PF02670, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal, score 2.9e-80 637910001070 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001071 PS00017 ATP/GTP-binding site motif A (P-loop). 637910001072 HMMPfam hit to PF08436, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal, score 5.6e-59 637910001073 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 637910001074 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 637910001075 catalytic residue [active] 637910001076 putative FPP diphosphate binding site; other site 637910001077 putative FPP binding hydrophobic cleft; other site 637910001078 dimer interface [polypeptide binding]; other site 637910001079 putative IPP diphosphate binding site; other site 637910001080 HMMPfam hit to PF01255, Di-trans-poly-cis-decaprenylcistransferase, score 1.7e-150 637910001081 PS01066 UDP pyrophosphate synthetase family signature. 637910001082 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 637910001083 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 637910001084 HMMPfam hit to PF01148, Phosphatidate cytidylyltransferase, score 1.4e-83 637910001085 8 transmembrane helices predicted for ROD01781 by TMHMM2.0 at aa 7-41, 56-74, 87-106, 121-143, 150-172, 192-211, 218-240 and 260-282 637910001086 PS01315 Phosphatidate cytidylyltransferase signature. 637910001087 zinc metallopeptidase RseP; Provisional; Region: PRK10779 637910001088 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 637910001089 active site 637910001090 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 637910001091 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 637910001092 protein binding site [polypeptide binding]; other site 637910001093 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 637910001094 putative substrate binding region [chemical binding]; other site 637910001095 4 transmembrane helices predicted for ROD01791 by TMHMM2.0 at aa 2-21, 98-120, 376-398 and 426-445 637910001096 HMMPfam hit to PF02163, Peptidase M50, score 3.3e-95 637910001097 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 637910001098 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 2.5e-13 637910001099 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 637910001100 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 637910001101 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 637910001102 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 637910001103 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 637910001104 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 637910001105 Surface antigen; Region: Bac_surface_Ag; pfam01103 637910001106 HMMPfam hit to PF07244, Surface antigen variable number, score 3.2e-11 637910001107 HMMPfam hit to PF07244, Surface antigen variable number, score 2.6e-16 637910001108 HMMPfam hit to PF07244, Surface antigen variable number, score 9.1e-19 637910001109 HMMPfam hit to PF07244, Surface antigen variable number, score 4.7e-16 637910001110 HMMPfam hit to PF07244, Surface antigen variable number, score 1.1e-21 637910001111 HMMPfam hit to PF01103, Bacterial surface antigen (D15), score 1.7e-76 637910001112 periplasmic chaperone; Provisional; Region: PRK10780 637910001113 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910001114 HMMPfam hit to PF03938, Outer membrane chaperone Skp (OmpH), score 1.2e-37 637910001115 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 637910001116 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 637910001117 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 637910001118 trimer interface [polypeptide binding]; other site 637910001119 active site 637910001120 UDP-GlcNAc binding site [chemical binding]; other site 637910001121 lipid binding site [chemical binding]; lipid-binding site 637910001122 HMMPfam hit to PF04613, UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD, score 3.3e-33 637910001123 PS00101 Hexapeptide-repeat containing-transferases signature. 637910001124 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.14 637910001125 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.0058 637910001126 PS00101 Hexapeptide-repeat containing-transferases signature. 637910001127 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.051 637910001128 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.019 637910001129 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.3 637910001130 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.021 637910001131 PS00101 Hexapeptide-repeat containing-transferases signature. 637910001132 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 1 637910001133 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 16 637910001134 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 637910001135 HMMPfam hit to PF07977, beta-hydroxyacyl-ACP dehydratase, FabA/FabZ, score 3.7e-68 637910001136 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 637910001137 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 637910001138 active site 637910001139 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.089 637910001140 PS00101 Hexapeptide-repeat containing-transferases signature. 637910001141 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.46 637910001142 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.84 637910001143 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 7.5 637910001144 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 85 637910001145 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.1 637910001146 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.2 637910001147 PS00101 Hexapeptide-repeat containing-transferases signature. 637910001148 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001149 PS00017 ATP/GTP-binding site motif A (P-loop). 637910001150 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 637910001151 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 637910001152 HMMPfam hit to PF02684, Glycosyl transferase, family 19, score 1.5e-214 637910001153 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 637910001154 RNA/DNA hybrid binding site [nucleotide binding]; other site 637910001155 active site 637910001156 HMMPfam hit to PF01351, Ribonuclease HII/HIII, score 7.3e-94 637910001157 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 637910001158 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 637910001159 putative active site [active] 637910001160 putative PHP Thumb interface [polypeptide binding]; other site 637910001161 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 637910001162 generic binding surface II; other site 637910001163 generic binding surface I; other site 637910001164 HMMPfam hit to PF02811, PHP, C-terminal, score 2.4e-60 637910001165 HMMPfam hit to PF07733, Bacterial DNA polymerase III, subunit alpha, score 0 637910001166 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 7.9e-13 637910001167 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 637910001168 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 637910001169 HMMPfam hit to PF03255, Acetyl-CoA carboxylase, subunit alpha, score 9e-102 637910001170 pseudogene, disrupted by ISCro1 insertion 637910001171 Transposase; Region: HTH_Tnp_1; pfam01527 637910001172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910001173 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910001174 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910001175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910001176 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910001177 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910001178 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910001179 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910001180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910001181 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910001182 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910001183 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910001184 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910001185 HMMPfam hit to PF00182, Glycoside hydrolase, family 19, catalytic, score 1.4e-30 637910001186 HMMPfam hit to PF00801, PKD, score 0.00016 637910001187 HMMPfam hit to PF02839, Carbohydrate-binding family V/XII, score 0.002 637910001188 lysine decarboxylase LdcC; Provisional; Region: PRK15399 637910001189 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 637910001190 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 637910001191 homodimer interface [polypeptide binding]; other site 637910001192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910001193 catalytic residue [active] 637910001194 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 637910001195 HMMPfam hit to PF03709, Orn/Lys/Arg decarboxylase, N-terminal, score 6.4e-42 637910001196 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase, major region, score 8.4e-287 637910001197 PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. 637910001198 HMMPfam hit to PF03711, Orn/Lys/Arg decarboxylase, C-terminal, score 1.1e-84 637910001199 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 637910001200 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 637910001201 putative metal binding site [ion binding]; other site 637910001202 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 1.7e-31 637910001203 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 637910001204 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 637910001205 Ligand Binding Site [chemical binding]; other site 637910001206 TilS substrate binding domain; Region: TilS; pfam09179 637910001207 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 637910001208 HMMPfam hit to PF01171, PP-loop, score 5.5e-87 637910001209 HMMPfam hit to PF09179, Protein of unkown function DUF1946, PP-loop ATpase, score 2.9e-89 637910001210 PS00334 Myb DNA-binding domain repeat signature 2. 637910001211 Rho-binding antiterminator; Provisional; Region: PRK11625 637910001212 HMMPfam hit to PF07073, Modulator of Rho-dependent transcription termination, score 2.2e-43 637910001213 hypothetical protein; Provisional; Region: PRK04964 637910001214 HMMPfam hit to PF06786, Protein of unknown function UPF0253, score 1.1e-41 637910001215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 637910001216 HMMPfam hit to PF07152, YaeQ, score 6.2e-122 637910001217 hypothetical protein; Provisional; Region: PRK09256 637910001218 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 637910001219 HMMPfam hit to PF00472, Class I peptide chain release factor, score 1.4e-37 637910001220 PS00745 Prokaryotic-type class I peptide chain release factors signature. 637910001221 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 637910001222 NlpE N-terminal domain; Region: NlpE; pfam04170 637910001223 HMMPfam hit to PF04170, Copper resistance lipoprotein NlpE, score 5e-124 637910001224 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001225 PS00283 Soybean trypsin inhibitor (Kunitz) protease inhibitors family signature. 637910001226 YadA-like C-terminal region; Region: YadA; pfam03895 637910001227 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 637910001228 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 637910001229 trimer interface [polypeptide binding]; other site 637910001230 eyelet of channel; other site 637910001231 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 637910001232 HMMPfam hit to PF00267, Porin, Gram-negative type, score 2.6e-166 637910001233 pseudogene, truncated by frameshift mutation 637910001234 HMMPfam hit to PF01609, Transposase, IS4-like, score 3.5e-20 637910001235 prolyl-tRNA synthetase; Provisional; Region: PRK09194 637910001236 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 637910001237 dimer interface [polypeptide binding]; other site 637910001238 motif 1; other site 637910001239 active site 637910001240 motif 2; other site 637910001241 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 637910001242 putative deacylase active site [active] 637910001243 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 637910001244 active site 637910001245 motif 3; other site 637910001246 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 637910001247 anticodon binding site; other site 637910001248 HMMPfam hit to PF03129, Anticodon-binding, score 3.6e-26 637910001249 HMMPfam hit to PF04073, YbaK/prolyl-tRNA synthetase associated region, score 5.6e-07 637910001250 HMMPfam hit to PF00587, Aminoacyl-tRNA synthetase, class II (G, H, P and S), score 1.2e-66 637910001251 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 637910001252 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 637910001253 homodimer interaction site [polypeptide binding]; other site 637910001254 cofactor binding site; other site 637910001255 HMMPfam hit to PF01980, Protein of unknown function UPF0066, score 7.6e-54 637910001256 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 637910001257 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001258 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 637910001259 lipoprotein, YaeC family; Region: TIGR00363 637910001260 HMMPfam hit to PF03180, NLPA lipoprotein, score 2.4e-148 637910001261 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910001263 dimer interface [polypeptide binding]; other site 637910001264 conserved gate region; other site 637910001265 ABC-ATPase subunit interface; other site 637910001266 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3.5e-22 637910001267 5 transmembrane helices predicted for ROD02081 by TMHMM2.0 at aa 20-42, 55-77, 82-104, 144-166 and 181-203 637910001268 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910001269 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 637910001270 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 637910001271 Walker A/P-loop; other site 637910001272 ATP binding site [chemical binding]; other site 637910001273 Q-loop/lid; other site 637910001274 ABC transporter signature motif; other site 637910001275 Walker B; other site 637910001276 D-loop; other site 637910001277 H-loop/switch region; other site 637910001278 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 637910001279 HMMPfam hit to PF00005, ABC transporter related, score 8.5e-76 637910001280 PS00211 ABC transporters family signature. 637910001281 PS00017 ATP/GTP-binding site motif A (P-loop). 637910001282 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 637910001283 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910001284 active site 637910001285 motif I; other site 637910001286 motif II; other site 637910001287 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 5.8e-08 637910001288 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 637910001289 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637910001290 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637910001291 HMMPfam hit to PF03797, Autotransporter beta-domain, score 2.3e-42 637910001292 HMMPfam hit to PF03212, Pertactin, score 2.3e-07 637910001293 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637910001294 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637910001295 active site 637910001296 catalytic tetrad [active] 637910001297 HMMPfam hit to PF00248, Aldo/keto reductase, score 4.8e-88 637910001298 PS00798 Aldo/keto reductase family signature 1. 637910001299 PS00062 Aldo/keto reductase family signature 2. 637910001300 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910001301 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910001302 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 637910001303 putative effector binding pocket; other site 637910001304 dimerization interface [polypeptide binding]; other site 637910001305 HMMPfam hit to PF03466, LysR, substrate-binding, score 9.9e-51 637910001306 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.3e-19 637910001307 PS00044 Bacterial regulatory proteins, lysR family signature. 637910001308 Predicted helix-turn-helix motif with score 1503.000, SD 4.31 at aa 18-39, sequence GSFSRAAEQLGQANSAVSRAVK 637910001309 hypothetical protein; Provisional; Region: PRK05421 637910001310 putative catalytic site [active] 637910001311 putative metal binding site [ion binding]; other site 637910001312 putative phosphate binding site [ion binding]; other site 637910001313 putative catalytic site [active] 637910001314 putative phosphate binding site [ion binding]; other site 637910001315 putative metal binding site [ion binding]; other site 637910001316 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 3.7e-22 637910001317 Methyltransferase domain; Region: Methyltransf_23; pfam13489 637910001318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910001319 S-adenosylmethionine binding site [chemical binding]; other site 637910001320 HMMPfam hit to PF08241, Methyltransferase type 11, score 2.1e-35 637910001321 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 637910001322 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637910001323 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637910001324 catalytic residue [active] 637910001325 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637910001326 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637910001327 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 2e-13 637910001328 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 2.6e-17 637910001329 Predicted helix-turn-helix motif with score 1013.000, SD 2.64 at aa 352-373, sequence DTLSGIASRLGVSTKDLQQWNK 637910001330 HMMPfam hit to PF01464, Lytic transglycosylase-like, catalytic, score 1.1e-39 637910001331 PS00922 Prokaryotic transglycosylases signature. 637910001332 HMMPfam hit to PF06474, MLTD-N, score 4.3e-39 637910001333 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001334 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 637910001335 HMMPfam hit to PF00753, beta-lactamase-like, score 1.2e-37 637910001336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910001337 HMMPfam hit to PF08241, Methyltransferase type 11, score 4e-06 637910001338 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 637910001339 RNA/DNA hybrid binding site [nucleotide binding]; other site 637910001340 active site 637910001341 HMMPfam hit to PF00075, Ribonuclease H, score 1.2e-70 637910001342 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 637910001343 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 637910001344 active site 637910001345 catalytic site [active] 637910001346 substrate binding site [chemical binding]; other site 637910001347 HMMPfam hit to PF00929, Exonuclease, RNase T and DNA polymerase III, score 1.5e-54 637910001348 C-N hydrolase family amidase; Provisional; Region: PRK10438 637910001349 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 637910001350 putative active site [active] 637910001351 catalytic triad [active] 637910001352 dimer interface [polypeptide binding]; other site 637910001353 multimer interface [polypeptide binding]; other site 637910001354 HMMPfam hit to PF00795, Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase, score 2.3e-07 637910001355 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 637910001356 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 637910001357 active site 637910001358 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 637910001359 HMMPfam hit to PF09317, Protein of unknown function DUF1974, score 4.1e-185 637910001360 HMMPfam hit to PF00441, Acyl-CoA oxidase/dehydrogenase, type 1, score 1.3e-09 637910001361 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal, score 7.5e-06 637910001362 2 transmembrane helices predicted for ROD02221 by TMHMM2.0 at aa 10-32 and 39-61 637910001363 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 637910001364 dimer interface [polypeptide binding]; other site 637910001365 active site 637910001366 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 1.8e-05 637910001367 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 637910001368 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 637910001369 putative active site [active] 637910001370 putative dimer interface [polypeptide binding]; other site 637910001371 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 3.4e-37 637910001372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 637910001373 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637910001374 HMMPfam hit to PF06104, Protein of unknown function DUF949, bacterial, score 2.1e-149 637910001375 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001376 1 transmembrane helix predicted for ROD02251 by TMHMM2.0 at aa 4-26 637910001377 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 637910001378 NlpC/P60 family; Region: NLPC_P60; pfam00877 637910001379 HMMPfam hit to PF00877, NLP/P60, score 3.9e-50 637910001380 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 637910001381 FHIPEP family; Region: FHIPEP; pfam00771 637910001382 HMMPfam hit to PF00771, Bacterial type III secretion FHIPEP, score 1.2e-268 637910001383 7 transmembrane helices predicted for ROD02271 by TMHMM2.0 at aa 13-32, 37-59, 66-88, 114-136, 204-226, 241-263 and 284-306 637910001384 PS00994 Bacterial export FHIPEP family signature. 637910001385 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 637910001386 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 637910001387 HMMPfam hit to PF01312, type III secretion exporter, score 4.1e-105 637910001388 4 transmembrane helices predicted for ROD02281 by TMHMM2.0 at aa 34-53, 93-115, 154-176 and 191-210 637910001389 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 637910001390 HMMPfam hit to PF01311, type III secretion system inner membrane R protein, score 3.9e-31 637910001391 6 transmembrane helices predicted for ROD02291 by TMHMM2.0 at aa 10-32, 44-63, 78-100, 129-151, 182-204 and 211-233 637910001392 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001393 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 637910001394 HMMPfam hit to PF01313, Bacterial export protein FliQ, family 3, score 6e-13 637910001395 2 transmembrane helices predicted for ROD02301 by TMHMM2.0 at aa 17-39 and 52-74 637910001396 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 637910001397 HMMPfam hit to PF00813, type III secretion system inner membrane P protein, score 3.9e-95 637910001398 5 transmembrane helices predicted for ROD02311 by TMHMM2.0 at aa 7-29, 49-79, 92-111, 185-207 and 214-236 637910001399 PS01061 Flagella transport protein fliP family signature 2. 637910001400 PS01060 Flagella transport protein fliP family signature 1. 637910001401 PS00041 Bacterial regulatory proteins, araC family signature. 637910001402 flagellar motor switch protein FliN; Region: fliN; TIGR02480 637910001403 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) protein, score 1.9e-16 637910001404 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 637910001405 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) protein, score 0.041 637910001406 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 637910001407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910001408 Walker A motif; other site 637910001409 ATP binding site [chemical binding]; other site 637910001410 Walker B motif; other site 637910001411 arginine finger; other site 637910001412 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 637910001413 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 6.6e-128 637910001414 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 637910001415 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 637910001416 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 637910001417 PS00688 Sigma-54 interaction domain C-terminal part signature. 637910001418 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 1.1e-07 637910001419 Predicted helix-turn-helix motif with score 1653.000, SD 4.82 at aa 296-317, sequence GNKNKIADLLGITPRALRYRLA 637910001420 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 637910001421 HMMPfam hit to PF02049, Flagellar hook-basal body complex protein FliE, score 9e-12 637910001422 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 637910001423 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 637910001424 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 637910001425 HMMPfam hit to PF01514, Secretory protein YscJ/FliF, score 2.1e-51 637910001426 2 transmembrane helices predicted for ROD02371 by TMHMM2.0 at aa 25-44 and 441-460 637910001427 HMMPfam hit to PF08345, Flagellar M-ring C-terminal, score 3.8e-54 637910001428 pseudogene, C-terminus missing, truncated by prophage CRP28 insertion 637910001429 prophage CRP28 637910001430 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 637910001431 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 637910001432 HMMPfam hit to PF08400, Prophage tail fibre N-terminal, score 2.5e-59 637910001433 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 637910001434 HMMPfam hit to PF02413, Phage tail assembly chaperone gp38, score 2.9e-41 637910001435 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 637910001436 Phage Tail Collar Domain; Region: Collar; pfam07484 637910001437 HMMPfam hit to PF03335, Phage tail fiber repeat, score 0.31 637910001438 HMMPfam hit to PF03335, Phage tail fiber repeat, score 0.52 637910001439 HMMPfam hit to PF03335, Phage tail fiber repeat, score 1.3 637910001440 HMMPfam hit to PF03335, Phage tail fiber repeat, score 0.77 637910001441 HMMPfam hit to PF07484, Phage Tail Collar, score 1.6e-19 637910001442 HMMPfam hit to PF03406, Phage tail fiber repeat 2, score 6.6e-12 637910001443 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 637910001444 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 637910001445 HMMPfam hit to PF04865, Phage baseplate assembly predicted J-like, score 1.3e-62 637910001446 Phage protein GP46; Region: GP46; cl01814 637910001447 HMMPfam hit to PF07409, Phage GP46, score 2.4e-31 637910001448 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 637910001449 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 637910001450 HMMPfam hit to PF06890, Bacteriophage Mu Gp45, score 5.4e-64 637910001451 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 637910001452 Ubiquitin-like proteins; Region: UBQ; cl00155 637910001453 charged pocket; other site 637910001454 hydrophobic patch; other site 637910001455 HMMPfam hit to PF06893, Bacteriophage Mu P, score 2.1e-87 637910001456 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 637910001457 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 637910001458 HMMPfam hit to PF07157, DNA circulation, N-terminal, score 2.7e-31 637910001459 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 637910001460 Coenzyme A transferase; Region: CoA_trans; cl17247 637910001461 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 637910001462 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 637910001463 HMMPfam hit to PF06274, Bacteriophage Mu tail sheath, score 4.4e-151 637910001464 Domain of unknown function (DUF1834); Region: DUF1834; pfam08873 637910001465 HMMPfam hit to PF08873, Protein of unknown function DUF1834, score 2.2e-54 637910001466 Protein of unknown function (DUF1320); Region: DUF1320; cl01818 637910001467 HMMPfam hit to PF07030, Protein of unknown function DUF1320, score 1.2e-34 637910001468 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 637910001469 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 637910001470 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 637910001471 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 637910001472 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 637910001473 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 637910001474 HMMPfam hit to PF05069, Phage virion morphogenesis ( tail completion) protein, score 2.8e-26 637910001475 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 637910001476 HMMPfam hit to PF04233, Phage head morphogenesis protein, SPP1 gp7, score 2e-43 637910001477 Protein of unknown function (DUF935); Region: DUF935; pfam06074 637910001478 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 637910001479 HMMPfam hit to PF06074, Protein of unknown function DUF935, score 8.9e-182 637910001480 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 637910001481 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 637910001482 DNA methylase; Region: N6_N4_Mtase; pfam01555 637910001483 HMMPfam hit to PF01555, DNA methylase N-4/N-6, score 1.6e-09 637910001484 PS00092 N-6 Adenine-specific DNA methylases signature. 637910001485 Protein of unknown function (DUF1804); Region: DUF1804; pfam08822 637910001486 HMMPfam hit to PF08822, Protein of unknown function DUF1804, score 1.3e-71 637910001487 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 637910001488 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 637910001489 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 637910001490 HMMPfam hit to PF05838, Protein of unknown function DUF847, score 5.4e-97 637910001491 Protein of unknown function (DUF754); Region: DUF754; pfam05449 637910001492 HMMPfam hit to PF05449, Protein of unknown function DUF754, score 1.3e-19 637910001493 3 transmembrane helices predicted for ROD02681 by TMHMM2.0 at aa 5-24, 37-54 and 59-81 637910001494 2 transmembrane helices predicted for ROD02691 by TMHMM2.0 at aa 20-42 and 55-77 637910001495 pseudogene, disrupted by ISCro3 insertion. Last 4 aa at C-terminus separated from N-terminus by IS element. Intact gene found in EPEC E2348/69 prophage PP9 637910001496 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 637910001497 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910001498 HMMPfam hit to PF01609, Transposase, IS4-like, score 3.6e-29 637910001499 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 637910001500 HMMPfam hit to PF06252, Protein of unknown function DUF1018, score 9.3e-20 637910001501 1 transmembrane helix predicted for ROD02733 by TMHMM2.0 at aa 4-21 637910001502 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001503 1 transmembrane helix predicted for ROD02751 by TMHMM2.0 at aa 17-34 637910001504 1 transmembrane helix predicted for ROD02781 by TMHMM2.0 at aa 15-37 637910001505 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 637910001506 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 637910001507 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910001508 HMMPfam hit to PF01609, Transposase, IS4-like, score 9.3e-30 637910001509 pseudogene, C-terminus missing, truncated by IS102 insertion 637910001510 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 637910001511 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 637910001512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 637910001513 PS00017 ATP/GTP-binding site motif A (P-loop). 637910001514 Predicted helix-turn-helix motif with score 1173.000, SD 3.18 at aa 16-37, sequence YTQTHVGRAIGRSSAVINQYLQ 637910001515 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 637910001516 Integrase core domain; Region: rve; pfam00665 637910001517 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 637910001518 HMMPfam hit to PF09299, Transposase-like, Mu, C-terminal, score 4e-23 637910001519 HMMPfam hit to PF00665, Integrase, catalytic core, score 2.5e-10 637910001520 HMMPfam hit to PF02316, Transposase MuA/Repressor CI, DNA-binding, score 3.6e-07 637910001521 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 637910001522 Predicted helix-turn-helix motif with score 1039.000, SD 2.73 at aa 26-47, sequence FTLRELSERAGLKKDSLKNALY 637910001523 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 637910001524 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 637910001525 HMMPfam hit to PF07022, Bacteriophage CI repressor, score 0.002 637910001526 Predicted helix-turn-helix motif with score 999.000, SD 2.59 at aa 29-50, sequence RSVRTAASDWGIPPSTLNNYIH 637910001527 pseudogene, N-terminus missing, truncated by prophage CRP28 insertion 637910001528 HMMPfam hit to PF00006, ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding, score 2.6e-117 637910001529 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 637910001530 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637910001531 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 637910001532 active site 637910001533 nucleotide binding site [chemical binding]; other site 637910001534 HIGH motif; other site 637910001535 KMSKS motif; other site 637910001536 HMMPfam hit to PF01467, Cytidylyltransferase, score 8.7e-21 637910001537 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 637910001538 pseudogene, truncated by premature stop codon 637910001539 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 1.5e-17 637910001540 FlgN protein; Region: FlgN; pfam05130 637910001541 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 637910001542 HMMPfam hit to PF04316, Anti-sigma-28 factor, FlgM, score 9.5e-08 637910001543 SAF-like; Region: SAF_2; pfam13144 637910001544 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 637910001545 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 637910001546 HMMPfam hit to PF08666, SAF domain, score 1.5e-06 637910001547 1 transmembrane helix predicted for ROD03041 by TMHMM2.0 at aa 69-91 637910001548 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 637910001549 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 637910001550 PS00588 Flagella basal body rod proteins signature. 637910001551 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 637910001552 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 637910001553 HMMPfam hit to PF06429, Protein of unknown function DUF1078, C-terminal, score 0.00019 637910001554 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 637910001555 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 637910001556 HMMPfam hit to PF03963, Flagellar hook capping protein, score 2e-11 637910001557 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 637910001558 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 637910001559 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 637910001560 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 637910001561 HMMPfam hit to PF00460, Flagellar basal body rod protein, score 1.4e-06 637910001562 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001563 HMMPfam hit to PF07559, Flagellar basal body FlaE, score 1.2e-24 637910001564 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001565 HMMPfam hit to PF06429, Protein of unknown function DUF1078, C-terminal, score 1.7e-15 637910001566 pseudogene, truncated by premature stop codon 637910001567 HMMPfam hit to PF00460, Flagellar basal body rod protein, score 1.9e-07 637910001568 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 637910001569 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 637910001570 HMMPfam hit to PF00460, Flagellar basal body rod protein, score 4.2e-13 637910001571 PS00588 Flagella basal body rod proteins signature. 637910001572 HMMPfam hit to PF06429, Protein of unknown function DUF1078, C-terminal, score 7.8e-17 637910001573 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 637910001574 Flagellar L-ring protein; Region: FlgH; pfam02107 637910001575 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001576 HMMPfam hit to PF02107, Flagellar L-ring protein, score 1.2e-40 637910001577 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 637910001578 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 637910001579 1 transmembrane helix predicted for ROD03131 by TMHMM2.0 at aa 13-32 637910001580 HMMPfam hit to PF02119, Flagellar P-ring protein, score 8.4e-163 637910001581 Rod binding protein; Region: Rod-binding; cl01626 637910001582 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 637910001583 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 637910001584 HMMPfam hit to PF00460, Flagellar basal body rod protein, score 0.00016 637910001585 HMMPfam hit to PF06429, Protein of unknown function DUF1078, C-terminal, score 2.1e-13 637910001586 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 637910001587 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 637910001588 HMMPfam hit to PF00669, Flagellin, N-terminal, score 2.5e-05 637910001589 PS00294 Prenyl group binding site (CAAX box). 637910001590 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637910001591 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637910001592 DNA binding site [nucleotide binding] 637910001593 1 transmembrane helix predicted for ROD03191 by TMHMM2.0 at aa 180-202 637910001594 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 8.4e-12 637910001595 flagellin; Reviewed; Region: PRK08869 637910001596 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 637910001597 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 637910001598 HMMPfam hit to PF00669, Flagellin, N-terminal, score 1.5e-42 637910001599 HMMPfam hit to PF00700, Flagellin, C-terminal, score 5.6e-23 637910001600 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 637910001601 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 637910001602 HMMPfam hit to PF02465, Flagellar hook-associated protein 2, N-terminal, score 5.7e-09 637910001603 HMMPfam hit to PF07195, Flagellar hook-associated 2, C-terminal, score 8.8e-54 637910001604 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 637910001605 HMMPfam hit to PF02561, Flagellar protein FliS, score 1.1e-20 637910001606 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 637910001607 HMMPfam hit to PF02120, Flagellar hook-length control protein, score 8.3e-13 637910001608 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 637910001609 1 transmembrane helix predicted for ROD03261 by TMHMM2.0 at aa 5-27 637910001610 HMMPfam hit to PF03748, Flagellar basal body-associated protein FliL, score 2.6e-05 637910001611 flagellar biosynthesis sigma factor; Provisional; Region: PRK12427 637910001612 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637910001613 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637910001614 DNA binding residues [nucleotide binding] 637910001615 HMMPfam hit to PF04542, RNA polymerase sigma-70 region 2, score 1.1e-12 637910001616 HMMPfam hit to PF04545, RNA polymerase sigma-70 region 4, score 2e-12 637910001617 Predicted helix-turn-helix motif with score 1465.000, SD 4.18 at aa 204-225, sequence MNLKEIALVLGLTEARICQMNK 637910001618 flagellar motor protein MotA; Provisional; Region: PRK12482 637910001619 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 637910001620 4 transmembrane helices predicted for ROD03281 by TMHMM2.0 at aa 5-22, 26-48, 172-191 and 195-217 637910001621 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel, score 0.001 637910001622 PS01307 Flagellar motor protein motA family signature. 637910001623 hypothetical protein; Validated; Region: PRK06778 637910001624 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 637910001625 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637910001626 ligand binding site [chemical binding]; other site 637910001627 1 transmembrane helix predicted for ROD03291 by TMHMM2.0 at aa 32-54 637910001628 HMMPfam hit to PF00691, Outer membrane protein, OmpA/MotB, C-terminal, score 5.3e-21 637910001629 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 637910001630 active site 637910001631 DNA polymerase IV; Validated; Region: PRK02406 637910001632 DNA binding site [nucleotide binding] 637910001633 HMMPfam hit to PF00817, UMUC-like DNA-repair protein, score 1.5e-137 637910001634 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 637910001635 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 637910001636 metal binding site [ion binding]; metal-binding site 637910001637 dimer interface [polypeptide binding]; other site 637910001638 HMMPfam hit to PF01546, Peptidase M20, score 1.4e-09 637910001639 HMMPfam hit to PF07687, Peptidase M20, dimerisation, score 1.2e-15 637910001640 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637910001641 active site 637910001642 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 3.1e-19 637910001643 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 637910001644 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 637910001645 HMMPfam hit to PF06500, Protein of unknown function DUF1100, hydrolase-like, score 4e-303 637910001646 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 637910001647 HMMPfam hit to PF07417, Transcriptional regulator Crl, score 3.7e-92 637910001648 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 637910001649 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 637910001650 trimer interface [polypeptide binding]; other site 637910001651 eyelet of channel; other site 637910001652 HMMPfam hit to PF00267, Porin, Gram-negative type, score 8.9e-200 637910001653 PS00576 General diffusion Gram-negative porins signature. 637910001654 gamma-glutamyl kinase; Provisional; Region: PRK05429 637910001655 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 637910001656 nucleotide binding site [chemical binding]; other site 637910001657 homotetrameric interface [polypeptide binding]; other site 637910001658 putative phosphate binding site [ion binding]; other site 637910001659 putative allosteric binding site; other site 637910001660 PUA domain; Region: PUA; pfam01472 637910001661 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 4.3e-59 637910001662 PS00902 Glutamate 5-kinase signature. 637910001663 HMMPfam hit to PF01472, PUA, score 8.5e-30 637910001664 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 637910001665 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 637910001666 putative catalytic cysteine [active] 637910001667 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 5.1e-07 637910001668 PS01223 Gamma-glutamyl phosphate reductase signature. 637910001669 CR_GI1 637910001670 pseudogene, N-terminus missing, C-terminal part truncated by premature stop codon 637910001671 HMMPfam hit to PF00665, Integrase, catalytic core, score 3.6e-30 637910001672 1 transmembrane helix predicted for ROD03421 by TMHMM2.0 at aa 7-29 637910001673 5 transmembrane helices predicted for ROD03431 by TMHMM2.0 at aa 21-43, 53-75, 82-104, 127-144 and 149-166 637910001674 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 637910001675 pseudogene, N-terminus missing, C-terminal part truncated by frameshift mutations 637910001676 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637910001677 4 transmembrane helices predicted for ROD03451 by TMHMM2.0 at aa 21-43, 251-273, 301-323 and 338-360 637910001678 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 5.5e-05 637910001679 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001680 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 637910001681 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 637910001682 HlyD family secretion protein; Region: HlyD_3; pfam13437 637910001683 1 transmembrane helix predicted for ROD03471 by TMHMM2.0 at aa 12-34 637910001684 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 637910001685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910001686 Walker A/P-loop; other site 637910001687 ATP binding site [chemical binding]; other site 637910001688 Q-loop/lid; other site 637910001689 ABC transporter signature motif; other site 637910001690 Walker B; other site 637910001691 D-loop; other site 637910001692 H-loop/switch region; other site 637910001693 HMMPfam hit to PF00005, ABC transporter related, score 4.9e-35 637910001694 PS00017 ATP/GTP-binding site motif A (P-loop). 637910001695 PS00211 ABC transporters family signature. 637910001696 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 637910001697 HMMPfam hit to PF04966, Carbohydrate-selective porin OprB, score 2e-113 637910001698 benzoate transport; Region: 2A0115; TIGR00895 637910001699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910001700 putative substrate translocation pore; other site 637910001701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910001702 PS00017 ATP/GTP-binding site motif A (P-loop). 637910001703 12 transmembrane helices predicted for ROD03501 by TMHMM2.0 at aa 42-64, 74-96, 103-125, 129-151, 164-186, 190-212, 276-298, 313-335, 342-361, 366-388, 408-430 and 434-453 637910001704 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 5.2e-49 637910001705 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001706 PS00217 Sugar transport proteins signature 2. 637910001707 PS00962 Ribosomal protein S2 signature 1. 637910001708 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637910001709 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910001710 DNA binding site [nucleotide binding] 637910001711 domain linker motif; other site 637910001712 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 637910001713 Predicted helix-turn-helix motif with score 1987.000, SD 5.95 at aa 16-37, sequence ATMRDVARAAGVSVSTVSRVLD 637910001714 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 9.8e-10 637910001715 PS00356 Bacterial regulatory proteins, lacI family signature. 637910001716 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 4.3e-17 637910001717 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 637910001718 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 637910001719 inhibitor site; inhibition site 637910001720 active site 637910001721 dimer interface [polypeptide binding]; other site 637910001722 catalytic residue [active] 637910001723 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase, score 1.2e-18 637910001724 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 637910001725 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 637910001726 HMMPfam hit to PF03605, Anaerobic c4-dicarboxylate membrane transporter score 2.3e-118 637910001727 11 transmembrane helices predicted for ROD03541 by TMHMM2.0 at aa 15-37, 46-63, 96-118, 130-152, 167-189, 217-239, 259-278, 285-307, 322-341, 354-376 and 406-428 637910001728 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001729 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001730 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001731 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 637910001732 12 transmembrane helices predicted for ROD03551 by TMHMM2.0 at aa 21-40, 55-77, 98-120, 135-157, 162-182, 202-221, 242-264, 290-312, 341-360, 364-386, 399-417 and 421-443 637910001733 HMMPfam hit to PF00324, Amino acid permease-associated region, score 5.2e-29 637910001734 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 637910001735 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 637910001736 HMMPfam hit to PF00120, Glutamine synthetase, catalytic region, score 2.2e-107 637910001737 PS00181 Glutamine synthetase ATP-binding region signature. 637910001738 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 637910001739 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 637910001740 catalytic triad [active] 637910001741 HMMPfam hit to PF07722, Peptidase C26, score 3.9e-110 637910001742 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 637910001743 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637910001744 non-specific DNA binding site [nucleotide binding]; other site 637910001745 salt bridge; other site 637910001746 sequence-specific DNA binding site [nucleotide binding]; other site 637910001747 Cupin domain; Region: Cupin_2; pfam07883 637910001748 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 7.1e-16 637910001749 Predicted helix-turn-helix motif with score 1738.000, SD 5.11 at aa 21-42, sequence LSQRRAAELSGLTHSAISTIEQ 637910001750 HMMPfam hit to PF07883, Cupin 2, conserved barrel, score 2.6e-22 637910001751 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 637910001752 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 637910001753 NAD(P) binding site [chemical binding]; other site 637910001754 catalytic residues [active] 637910001755 PS00070 Aldehyde dehydrogenases cysteine active site. 637910001756 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 2.9e-235 637910001757 PS00017 ATP/GTP-binding site motif A (P-loop). 637910001758 PS00687 Aldehyde dehydrogenases glutamic acid active site. 637910001759 PS00070 Aldehyde dehydrogenases cysteine active site. 637910001760 PS00018 EF-hand calcium-binding domain. 637910001761 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 637910001762 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 637910001763 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 2.7e-102 637910001764 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 637910001765 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637910001766 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637910001767 HMMPfam hit to PF03797, Autotransporter beta-domain, score 4.3e-36 637910001768 HMMPfam hit to PF03212, Pertactin, score 1e-44 637910001769 1 transmembrane helix predicted for ROD03611 by TMHMM2.0 at aa 55-77 637910001770 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 637910001771 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637910001772 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 8.6e-06 637910001773 1 transmembrane helix predicted for ROD03641 by TMHMM2.0 at aa 7-24 637910001774 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 637910001775 PapC N-terminal domain; Region: PapC_N; pfam13954 637910001776 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637910001777 PapC C-terminal domain; Region: PapC_C; pfam13953 637910001778 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 4.4e-273 637910001779 putative chaperone protein EcpD; Provisional; Region: PRK09926 637910001780 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637910001781 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637910001782 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 4.1e-09 637910001783 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 3.3e-59 637910001784 PS00635 Gram-negative pili assembly chaperone signature. 637910001785 1 transmembrane helix predicted for ROD03661 by TMHMM2.0 at aa 7-29 637910001786 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637910001787 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 1.5e-26 637910001788 1 transmembrane helix predicted for ROD03681 by TMHMM2.0 at aa 58-80 637910001789 2 transmembrane helices predicted for ROD03691 by TMHMM2.0 at aa 12-33 and 48-70 637910001790 PS00228 Tubulin-beta mRNA autoregulation signal. 637910001791 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 637910001792 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 637910001793 putative active site [active] 637910001794 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637910001795 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910001796 Walker A/P-loop; other site 637910001797 ATP binding site [chemical binding]; other site 637910001798 Q-loop/lid; other site 637910001799 ABC transporter signature motif; other site 637910001800 Walker B; other site 637910001801 D-loop; other site 637910001802 H-loop/switch region; other site 637910001803 HMMPfam hit to PF00005, ABC transporter related, score 3.3e-58 637910001804 PS00211 ABC transporters family signature. 637910001805 PS00017 ATP/GTP-binding site motif A (P-loop). 637910001806 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 2.4e-28 637910001807 5 transmembrane helices predicted for ROD03701 by TMHMM2.0 at aa 165-187, 207-229, 286-308, 312-329 and 392-414 637910001808 HMMPfam hit to PF03412, Peptidase C39, bacteriocin processing, score 1.1e-42 637910001809 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 637910001810 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 637910001811 HlyD family secretion protein; Region: HlyD_3; pfam13437 637910001812 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 0.00021 637910001813 1 transmembrane helix predicted for ROD03711 by TMHMM2.0 at aa 49-71 637910001814 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 637910001815 HMMPfam hit to PF02321, Outer membrane efflux protein, score 7.9e-34 637910001816 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.7e-26 637910001817 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637910001818 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910001819 DNA binding residues [nucleotide binding] 637910001820 dimerization interface [polypeptide binding]; other site 637910001821 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 3.2e-12 637910001822 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 637910001823 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 637910001824 active site 637910001825 HMMPfam hit to PF01844, HNH endonuclease, score 1.7e-07 637910001826 1 transmembrane helix predicted for ROD03751 by TMHMM2.0 at aa 4-26 637910001827 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 637910001828 non-specific DNA interactions [nucleotide binding]; other site 637910001829 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 637910001830 DNA binding site [nucleotide binding] 637910001831 sequence specific DNA binding site [nucleotide binding]; other site 637910001832 putative cAMP binding site [chemical binding]; other site 637910001833 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 637910001834 HMMPfam hit to PF04198, sugar-binding region, score 2.8e-94 637910001835 Predicted helix-turn-helix motif with score 1587.000, SD 4.59 at aa 25-46, sequence ITQEEIANKFGFSRIKVGRLLK 637910001836 dihydroxyacetone kinase; Provisional; Region: PRK14479 637910001837 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 637910001838 DAK2 domain; Region: Dak2; pfam02734 637910001839 HMMPfam hit to PF02734, Dak phosphatase, score 4.6e-55 637910001840 HMMPfam hit to PF02733, Dak kinase, score 3.2e-128 637910001841 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001842 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 637910001843 HMMPfam hit to PF02502, Ribose/galactose isomerase, score 8.2e-75 637910001844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910001845 D-galactonate transporter; Region: 2A0114; TIGR00893 637910001846 putative substrate translocation pore; other site 637910001847 10 transmembrane helices predicted for ROD03791 by TMHMM2.0 at aa 12-34, 47-69, 81-103, 163-185, 231-253, 263-285, 298-320, 325-347, 360-382 and 392-409 637910001848 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 6.5e-63 637910001849 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 637910001850 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 637910001851 HMMPfam hit to PF04166, Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA, score 5.3e-120 637910001852 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 637910001853 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 637910001854 Metal-binding active site; metal-binding site 637910001855 HMMPfam hit to PF01261, Xylose isomerase-type TIM barrel, score 1.4e-27 637910001856 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 637910001857 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 637910001858 putative NAD(P) binding site [chemical binding]; other site 637910001859 putative substrate binding site [chemical binding]; other site 637910001860 catalytic Zn binding site [ion binding]; other site 637910001861 structural Zn binding site [ion binding]; other site 637910001862 dimer interface [polypeptide binding]; other site 637910001863 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 1.5e-34 637910001864 PS00190 Cytochrome c family heme-binding site signature. 637910001865 PS00059 Zinc-containing alcohol dehydrogenases signature. 637910001866 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 5.2e-38 637910001867 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 637910001868 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 637910001869 Ligand binding site; other site 637910001870 metal-binding site 637910001871 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 637910001872 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 637910001873 XdhC Rossmann domain; Region: XdhC_C; pfam13478 637910001874 HMMPfam hit to PF02625, XdhC- CoxI, score 2e-26 637910001875 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001876 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 637910001877 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 637910001878 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 637910001879 HMMPfam hit to PF02738, Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding, score 2.9e-153 637910001880 HMMPfam hit to PF01315, Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead, score 1.3e-31 637910001881 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 637910001882 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 637910001883 HMMPfam hit to PF00941, Molybdopterin dehydrogenase, FAD-binding, score 1.6e-91 637910001884 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 637910001885 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637910001886 catalytic loop [active] 637910001887 iron binding site [ion binding]; other site 637910001888 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 637910001889 HMMPfam hit to PF01799, [2Fe-2S]-binding, score 9.9e-44 637910001890 HMMPfam hit to PF00111, Ferredoxin, score 3.9e-13 637910001891 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 637910001892 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 637910001893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910001894 putative substrate translocation pore; other site 637910001895 POT family; Region: PTR2; cl17359 637910001896 14 transmembrane helices predicted for ROD03881 by TMHMM2.0 at aa 34-56, 61-83, 92-114, 119-141, 154-176, 181-203, 233-255, 265-287, 294-311, 337-359, 371-393, 408-430, 443-465 and 476-498 637910001897 PS01022 PTR2 family proton/oligopeptide symporters signature 1. 637910001898 HMMPfam hit to PF00854, TGF-beta receptor, type I/II extracellular region, score 4.3e-39 637910001899 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 637910001900 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 637910001901 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637910001902 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637910001903 HMMPfam hit to PF03212, Pertactin, score 7.2e-07 637910001904 HMMPfam hit to PF03797, Autotransporter beta-domain, score 2e-42 637910001905 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 637910001906 HMMPfam hit to PF01654, Cytochrome bd ubiquinol oxidase, subunit I, score 1.1e-238 637910001907 9 transmembrane helices predicted for ROD03901 by TMHMM2.0 at aa 20-42, 55-77, 97-119, 126-148, 185-207, 220-237, 322-344, 357-379 and 407-429 637910001908 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 637910001909 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 637910001910 HMMPfam hit to PF02322, Cytochrome bd ubiquinol oxidase, subunit II, score 7.1e-148 637910001911 8 transmembrane helices predicted for ROD03911 by TMHMM2.0 at aa 7-26, 74-96, 117-139, 159-181, 194-216, 231-248, 261-283 and 303-325 637910001912 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 637910001913 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637910001914 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637910001915 HMMPfam hit to PF03797, Autotransporter beta-domain, score 2e-41 637910001916 PS00017 ATP/GTP-binding site motif A (P-loop). 637910001917 HMMPfam hit to PF03212, Pertactin, score 2.1e-06 637910001918 1 transmembrane helix predicted for ROD03921 by TMHMM2.0 at aa 5-27 637910001919 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 637910001920 Propionate catabolism activator; Region: PrpR_N; pfam06506 637910001921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910001922 Walker A motif; other site 637910001923 ATP binding site [chemical binding]; other site 637910001924 Walker B motif; other site 637910001925 arginine finger; other site 637910001926 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 637910001927 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 1.6e-08 637910001928 Predicted helix-turn-helix motif with score 1370.000, SD 3.85 at aa 533-554, sequence GDKRAAARYLGISRTTFWRRLK 637910001929 PS00688 Sigma-54 interaction domain C-terminal part signature. 637910001930 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 1.3e-126 637910001931 PS00134 Serine proteases, trypsin family, histidine active site. 637910001932 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 637910001933 HMMPfam hit to PF06506, Propionate catabolism activator, N-terminal, score 4e-92 637910001934 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 637910001935 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 637910001936 tetramer interface [polypeptide binding]; other site 637910001937 active site 637910001938 Mg2+/Mn2+ binding site [ion binding]; other site 637910001939 HMMPfam hit to PF00463, Isocitrate lyase and phosphorylmutase, score 2.7e-08 637910001940 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 637910001941 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 637910001942 dimer interface [polypeptide binding]; other site 637910001943 active site 637910001944 citrylCoA binding site [chemical binding]; other site 637910001945 oxalacetate/citrate binding site [chemical binding]; other site 637910001946 coenzyme A binding site [chemical binding]; other site 637910001947 catalytic triad [active] 637910001948 HMMPfam hit to PF00285, Citrate synthase, score 3.5e-98 637910001949 PS00017 ATP/GTP-binding site motif A (P-loop). 637910001950 PS00480 Citrate synthase signature. 637910001951 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 637910001952 2-methylcitrate dehydratase; Region: prpD; TIGR02330 637910001953 HMMPfam hit to PF03972, MmgE/PrpD, score 2.6e-240 637910001954 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 637910001955 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 637910001956 acyl-activating enzyme (AAE) consensus motif; other site 637910001957 AMP binding site [chemical binding]; other site 637910001958 active site 637910001959 CoA binding site [chemical binding]; other site 637910001960 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 5e-111 637910001961 PS00455 AMP-binding domain signature. 637910001962 galactoside permease; Reviewed; Region: lacY; PRK09528 637910001963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910001964 putative substrate translocation pore; other site 637910001965 HMMPfam hit to PF01306, Proton/sugar symporter, LacY, score 0 637910001966 10 transmembrane helices predicted for ROD03981 by TMHMM2.0 at aa 13-35, 45-67, 76-98, 103-125, 145-164, 168-187, 260-282, 312-334, 347-369 and 379-401 637910001967 PS00897 LacY family proton/sugar symporters signature 2. 637910001968 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910001969 PS00896 LacY family proton/sugar symporters signature 1. 637910001970 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 637910001971 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 637910001972 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 637910001973 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 637910001974 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 637910001975 HMMPfam hit to PF02929, Glycoside hydrolase, family 42, domain 5, score 6.2e-140 637910001976 HMMPfam hit to PF02836, Glycoside hydrolase family 2, TIM barrel, score 2.4e-188 637910001977 PS00608 Glycosyl hydrolases family 2 acid/base catalyst. 637910001978 PS00719 Glycosyl hydrolases family 2 signature 1. 637910001979 HMMPfam hit to PF00703, Glycoside hydrolase family 2, immunoglobulin-like beta-sandwich, score 3.2e-47 637910001980 HMMPfam hit to PF02837, Glycoside hydrolase family 2, carbohydrate-binding, score 2.3e-92 637910001981 lac repressor; Reviewed; Region: lacI; PRK09526 637910001982 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910001983 DNA binding site [nucleotide binding] 637910001984 domain linker motif; other site 637910001985 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 637910001986 ligand binding site [chemical binding]; other site 637910001987 dimerization interface (open form) [polypeptide binding]; other site 637910001988 dimerization interface (closed form) [polypeptide binding]; other site 637910001989 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 1.2e-13 637910001990 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 1.9e-11 637910001991 Predicted helix-turn-helix motif with score 2026.000, SD 6.09 at aa 6-27, sequence VTLYDVANHAGVSYQTVSRVVN 637910001992 PS00356 Bacterial regulatory proteins, lacI family signature. 637910001993 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 637910001994 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 637910001995 conserved cys residue [active] 637910001996 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910001997 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.3e-06 637910001998 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 4.1e-05 637910001999 Predicted helix-turn-helix motif with score 1516.000, SD 4.35 at aa 228-249, sequence HDLNSLAQRVRMSRRTLSRHFM 637910002000 HMMPfam hit to PF01965, ThiJ/PfpI, score 3.7e-05 637910002001 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 637910002002 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 637910002003 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 637910002004 4 transmembrane helices predicted for ROD04031 by TMHMM2.0 at aa 30-52, 72-94, 107-129 and 139-156 637910002005 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 637910002006 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910002007 Walker A/P-loop; other site 637910002008 ATP binding site [chemical binding]; other site 637910002009 Q-loop/lid; other site 637910002010 ABC transporter signature motif; other site 637910002011 Walker B; other site 637910002012 D-loop; other site 637910002013 H-loop/switch region; other site 637910002014 TOBE domain; Region: TOBE_2; pfam08402 637910002015 HMMPfam hit to PF08402, Transport-associated OB, type 2, score 1.7e-15 637910002016 HMMPfam hit to PF00005, ABC transporter related, score 3e-67 637910002017 PS00211 ABC transporters family signature. 637910002018 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002019 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 637910002020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910002021 dimer interface [polypeptide binding]; other site 637910002022 conserved gate region; other site 637910002023 putative PBP binding loops; other site 637910002024 ABC-ATPase subunit interface; other site 637910002025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910002026 dimer interface [polypeptide binding]; other site 637910002027 conserved gate region; other site 637910002028 putative PBP binding loops; other site 637910002029 ABC-ATPase subunit interface; other site 637910002030 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3.2e-07 637910002031 16 transmembrane helices predicted for ROD04051 by TMHMM2.0 at aa 16-35, 50-72, 85-105, 110-132, 145-167, 187-218, 231-253, 273-295, 325-347, 381-403, 424-446, 488-510, 522-541, 546-568, 611-633 and 656-678 637910002032 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 9.3e-10 637910002033 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002034 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 637910002035 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 637910002036 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 4.8e-12 637910002037 regulatory protein UhpC; Provisional; Region: PRK11663 637910002038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910002039 putative substrate translocation pore; other site 637910002040 12 transmembrane helices predicted for ROD04071 by TMHMM2.0 at aa 13-32, 56-78, 85-103, 107-129, 142-164, 169-191, 240-259, 274-296, 308-330, 334-356, 365-387 and 402-424 637910002041 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.8e-47 637910002042 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002043 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 637910002044 MASE1; Region: MASE1; pfam05231 637910002045 Histidine kinase; Region: HisKA_3; pfam07730 637910002046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910002047 ATP binding site [chemical binding]; other site 637910002048 Mg2+ binding site [ion binding]; other site 637910002049 G-X-G motif; other site 637910002050 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.3e-20 637910002051 HMMPfam hit to PF07730, Histidine kinase, dimerisation and phosphoacceptor region, score 1e-16 637910002052 HMMPfam hit to PF05231, MASE1, score 1.3e-59 637910002053 8 transmembrane helices predicted for ROD04081 by TMHMM2.0 at aa 10-32, 39-60, 80-102, 115-137, 141-163, 184-206, 229-251 and 258-280 637910002054 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637910002055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910002056 active site 637910002057 phosphorylation site [posttranslational modification] 637910002058 intermolecular recognition site; other site 637910002059 dimerization interface [polypeptide binding]; other site 637910002060 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910002061 DNA binding residues [nucleotide binding] 637910002062 dimerization interface [polypeptide binding]; other site 637910002063 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 1.3e-24 637910002064 PS00622 Bacterial regulatory proteins, luxR family signature. 637910002065 HMMPfam hit to PF00072, Response regulator receiver, score 2e-33 637910002066 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 637910002067 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637910002068 substrate binding pocket [chemical binding]; other site 637910002069 membrane-bound complex binding site; other site 637910002070 hinge residues; other site 637910002071 HMMPfam hit to PF04069, Substrate-binding region of ABC-type glycine betaine transport system, score 2e-26 637910002072 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 637910002073 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 637910002074 Walker A/P-loop; other site 637910002075 ATP binding site [chemical binding]; other site 637910002076 Q-loop/lid; other site 637910002077 ABC transporter signature motif; other site 637910002078 Walker B; other site 637910002079 D-loop; other site 637910002080 H-loop/switch region; other site 637910002081 HMMPfam hit to PF00005, ABC transporter related, score 2.8e-53 637910002082 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002083 PS00211 ABC transporters family signature. 637910002084 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 637910002085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910002086 dimer interface [polypeptide binding]; other site 637910002087 conserved gate region; other site 637910002088 putative PBP binding loops; other site 637910002089 ABC-ATPase subunit interface; other site 637910002090 6 transmembrane helices predicted for ROD04121 by TMHMM2.0 at aa 21-43, 87-109, 121-143, 148-167, 188-210 and 238-260 637910002091 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 6.1e-21 637910002092 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910002093 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 637910002094 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 637910002095 HMMPfam hit to PF02668, Taurine catabolism dioxygenase TauD/TfdA, score 1.7e-121 637910002096 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 637910002097 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 637910002098 dimer interface [polypeptide binding]; other site 637910002099 active site 637910002100 Schiff base residues; other site 637910002101 HMMPfam hit to PF00490, Tetrapyrrole biosynthesis, porphobilinogen synthase, score 1.2e-226 637910002102 PS00169 Delta-aminolevulinic acid dehydratase active site. 637910002103 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 637910002104 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637910002105 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637910002106 HMMPfam hit to PF03797, Autotransporter beta-domain, score 9.5e-32 637910002107 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 637910002108 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 637910002109 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 637910002110 HMMPfam hit to PF00144, beta-lactamase, score 3.9e-74 637910002111 microcin B17 transporter; Reviewed; Region: PRK11098 637910002112 8 transmembrane helices predicted for ROD04181 by TMHMM2.0 at aa 12-31, 56-78, 85-107, 137-159, 206-228, 243-265, 332-354 and 364-383 637910002113 HMMPfam hit to PF05992, SbmABacA-like, score 1.5e-239 637910002114 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 637910002115 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002116 HMMPfam hit to PF07759, Protein of unknown function DUF1615, score 7.4e-240 637910002117 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002118 Predicted helix-turn-helix motif with score 1577.000, SD 4.56 at aa 277-298, sequence LAVRKLADKLDLSESAIRRQLE 637910002119 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 637910002120 2 transmembrane helices predicted for ROD04201 by TMHMM2.0 at aa 25-47 and 68-90 637910002121 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 637910002122 2 transmembrane helices predicted for ROD04211 by TMHMM2.0 at aa 22-44 and 48-70 637910002123 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 637910002124 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 637910002125 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 637910002126 HMMPfam hit to PF07478, D-alanine--D-alanine ligase, C-terminal, score 5.2e-123 637910002127 PS00844 D-alanine--D-alanine ligase signature 2. 637910002128 HMMPfam hit to PF01820, D-alanine--D-alanine ligase, N-terminal, score 3e-82 637910002129 PS00843 D-alanine--D-alanine ligase signature 1. 637910002130 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002131 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 637910002132 1 transmembrane helix predicted for ROD04241 by TMHMM2.0 at aa 13-30 637910002133 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002134 HMMPfam hit to PF06904, Extensin-like, C-terminal, score 8e-59 637910002135 drug efflux system protein MdtG; Provisional; Region: PRK09874 637910002136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910002137 putative substrate translocation pore; other site 637910002138 12 transmembrane helices predicted for ROD04251 by TMHMM2.0 at aa 7-29, 44-66, 78-97, 102-124, 136-158, 162-184, 204-226, 249-271, 283-302, 307-329, 341-363 and 367-389 637910002139 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 3.2e-49 637910002140 anti-RssB factor; Provisional; Region: PRK10244 637910002141 alkaline phosphatase; Provisional; Region: PRK10518 637910002142 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 637910002143 dimer interface [polypeptide binding]; other site 637910002144 active site 637910002145 HMMPfam hit to PF00245, Alkaline phosphatase, score 1.3e-152 637910002146 PS00123 Alkaline phosphatase active site. 637910002147 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002148 hypothetical protein; Provisional; Region: PRK11505 637910002149 psiF repeat; Region: PsiF_repeat; pfam07769 637910002150 psiF repeat; Region: PsiF_repeat; pfam07769 637910002151 1 transmembrane helix predicted for ROD04281 by TMHMM2.0 at aa 5-22 637910002152 HMMPfam hit to PF07769, PsiF, score 1.6e-18 637910002153 HMMPfam hit to PF07769, PsiF, score 1.7e-21 637910002154 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 637910002155 MASE2 domain; Region: MASE2; pfam05230 637910002156 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637910002157 metal binding site [ion binding]; metal-binding site 637910002158 active site 637910002159 I-site; other site 637910002160 HMMPfam hit to PF05230, MASE2, score 2.2e-89 637910002161 4 transmembrane helices predicted for ROD04291 by TMHMM2.0 at aa 41-63, 103-125, 137-156 and 161-183 637910002162 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002163 HMMPfam hit to PF00990, GGDEF, score 1.6e-65 637910002164 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 637910002165 pyrroline-5-carboxylate reductase; Region: PLN02688 637910002166 HMMPfam hit to PF03807, NADP oxidoreductase, coenzyme F420-dependent, score 1.2e-97 637910002167 PS00521 Delta 1-pyrroline-5-carboxylate reductase signature. 637910002168 PS00107 Protein kinases ATP-binding region signature. 637910002169 hypothetical protein; Validated; Region: PRK00124 637910002170 HMMPfam hit to PF02639, Protein of unknown function DUF188, score 3.3e-87 637910002171 Shikimate kinase; Region: SKI; pfam01202 637910002172 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 637910002173 magnesium binding site [ion binding]; other site 637910002174 putative shikimate binding site; other site 637910002175 HMMPfam hit to PF01202, Shikimate kinase, score 1e-51 637910002176 PS01128 Shikimate kinase signature. 637910002177 hypothetical protein; Provisional; Region: PRK10380 637910002178 hypothetical protein; Provisional; Region: PRK10481 637910002179 HMMPfam hit to PF07302, AroM, score 2.1e-131 637910002180 hypothetical protein; Provisional; Region: PRK10579 637910002181 HMMPfam hit to PF06865, Protein of unknown function DUF1255, score 5e-64 637910002182 recombination associated protein; Reviewed; Region: rdgC; PRK00321 637910002183 HMMPfam hit to PF04381, exonuclease, RdgC, score 6.3e-213 637910002184 fructokinase; Reviewed; Region: PRK09557 637910002185 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637910002186 nucleotide binding site [chemical binding]; other site 637910002187 HMMPfam hit to PF00480, ROK, score 4.6e-93 637910002188 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002189 PS01125 ROK family signature. 637910002190 MFS transport protein AraJ; Provisional; Region: PRK10091 637910002191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910002192 putative substrate translocation pore; other site 637910002193 12 transmembrane helices predicted for ROD04391 by TMHMM2.0 at aa 5-27, 42-63, 70-89, 94-116, 129-151, 156-178, 199-221, 236-255, 262-284, 288-310, 331-353 and 357-376 637910002194 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002195 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 5.9e-49 637910002196 Predicted helix-turn-helix motif with score 1072.000, SD 2.84 at aa 24-45, sequence GVLTELARDVGITIPAAGHMIS 637910002197 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637910002198 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637910002199 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637910002200 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 2.7e-31 637910002201 exonuclease subunit SbcC; Provisional; Region: PRK10246 637910002202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910002203 Walker A/P-loop; other site 637910002204 ATP binding site [chemical binding]; other site 637910002205 Q-loop/lid; other site 637910002206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910002207 ABC transporter signature motif; other site 637910002208 Walker B; other site 637910002209 D-loop; other site 637910002210 H-loop/switch region; other site 637910002211 HMMPfam hit to PF02463, SMC protein, N-terminal, score 1e-05 637910002212 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002213 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002214 exonuclease subunit SbcD; Provisional; Region: PRK10966 637910002215 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 637910002216 active site 637910002217 metal binding site [ion binding]; metal-binding site 637910002218 DNA binding site [nucleotide binding] 637910002219 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 637910002220 HMMPfam hit to PF00149, Metallophosphoesterase, score 1e-19 637910002221 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002222 transcriptional regulator PhoB; Provisional; Region: PRK10161 637910002223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910002224 active site 637910002225 phosphorylation site [posttranslational modification] 637910002226 intermolecular recognition site; other site 637910002227 dimerization interface [polypeptide binding]; other site 637910002228 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637910002229 DNA binding site [nucleotide binding] 637910002230 HMMPfam hit to PF00072, Response regulator receiver, score 5.2e-41 637910002231 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1e-25 637910002232 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 637910002233 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 637910002234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637910002235 putative active site [active] 637910002236 heme pocket [chemical binding]; other site 637910002237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637910002238 dimer interface [polypeptide binding]; other site 637910002239 phosphorylation site [posttranslational modification] 637910002240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910002241 ATP binding site [chemical binding]; other site 637910002242 Mg2+ binding site [ion binding]; other site 637910002243 G-X-G motif; other site 637910002244 1 transmembrane helix predicted for ROD04441 by TMHMM2.0 at aa 12-34 637910002245 HMMPfam hit to PF00989, PAS fold, score 1.1e-18 637910002246 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 3.3e-21 637910002247 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.6e-43 637910002248 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 637910002249 HMMPfam hit to PF05525, Branched-chain amino acid transport system II carrier protein, score 3.9e-240 637910002250 12 transmembrane helices predicted for ROD04451 by TMHMM2.0 at aa 13-35, 41-63, 76-98, 118-140, 147-169, 189-211, 223-245, 276-298, 305-327, 337-359, 371-393 and 408-426 637910002251 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002252 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002253 putative proline-specific permease; Provisional; Region: proY; PRK10580 637910002254 HMMPfam hit to PF00324, Amino acid permease-associated region, score 6.2e-134 637910002255 12 transmembrane helices predicted for ROD04461 by TMHMM2.0 at aa 16-34, 44-63, 83-105, 120-142, 154-176, 196-218, 239-261, 276-298, 329-351, 356-378, 399-421 and 426-445 637910002256 PS00218 Amino acid permeases signature. 637910002257 maltodextrin glucosidase; Provisional; Region: PRK10785 637910002258 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 637910002259 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 637910002260 active site 637910002261 homodimer interface [polypeptide binding]; other site 637910002262 catalytic site [active] 637910002263 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 1.2e-109 637910002264 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 637910002265 25 transmembrane helices predicted for ROD04491 by TMHMM2.0 at aa 4-26, 133-152, 162-179, 186-208, 213-235, 240-257, 262-284, 289-306, 316-338, 350-367, 372-394, 401-423, 428-445, 452-471, 476-498, 507-529, 533-550, 618-640, 655-672, 685-707, 717-739, 752-774, 789-811, 824-841 and 847-869 637910002266 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 637910002267 1 transmembrane helix predicted for ROD04501 by TMHMM2.0 at aa 432-454 637910002268 peroxidase; Provisional; Region: PRK15000 637910002269 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 637910002270 dimer interface [polypeptide binding]; other site 637910002271 decamer (pentamer of dimers) interface [polypeptide binding]; other site 637910002272 catalytic triad [active] 637910002273 peroxidatic and resolving cysteines [active] 637910002274 HMMPfam hit to PF00578, Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen, score 7.4e-46 637910002275 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 637910002276 HMMPfam hit to PF04336, Protein of unknown function DUF479, score 3.6e-114 637910002277 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 637910002278 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 637910002279 HMMPfam hit to PF02547, Queuosine biosynthesis protein, score 3.3e-150 637910002280 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 637910002281 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 637910002282 HMMPfam hit to PF01702, Queuine/other tRNA-ribosyltransferase, score 5.3e-171 637910002283 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 637910002284 HMMPfam hit to PF02699, YajC, score 1.6e-47 637910002285 1 transmembrane helix predicted for ROD04551 by TMHMM2.0 at aa 20-39 637910002286 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 637910002287 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 637910002288 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 637910002289 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 637910002290 6 transmembrane helices predicted for ROD04561 by TMHMM2.0 at aa 7-29, 452-471, 476-498, 503-525, 546-568 and 583-605 637910002291 HMMPfam hit to PF07549, SecD/SecF/SecDF export membrane protein, score 6.1e-06 637910002292 PS00761 Signal peptidases I signature 3. 637910002293 HMMPfam hit to PF02355, SecD/SecF/SecDF export membrane protein, score 5.8e-06 637910002294 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 637910002295 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 637910002296 Protein export membrane protein; Region: SecD_SecF; pfam02355 637910002297 6 transmembrane helices predicted for ROD04571 by TMHMM2.0 at aa 24-46, 143-162, 169-191, 195-217, 248-270 and 275-297 637910002298 HMMPfam hit to PF07549, SecD/SecF/SecDF export membrane protein, score 0.00037 637910002299 HMMPfam hit to PF02355, SecD/SecF/SecDF export membrane protein, score 2.8e-94 637910002300 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 637910002301 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 637910002302 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 2.6e-10 637910002303 Predicted transcriptional regulator [Transcription]; Region: COG2378 637910002304 HTH domain; Region: HTH_11; pfam08279 637910002305 WYL domain; Region: WYL; pfam13280 637910002306 HMMPfam hit to PF08279, Helix-turn-helix, type 11, score 7.3e-21 637910002307 Predicted helix-turn-helix motif with score 1969.000, SD 5.89 at aa 21-42, sequence TTAALLAERLGVSERTIYRDIR 637910002308 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 637910002309 HMMPfam hit to PF03502, Nucleoside-specific channel-forming protein, Tsx, score 1.5e-109 637910002310 hypothetical protein; Provisional; Region: PRK11530 637910002311 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 637910002312 ATP cone domain; Region: ATP-cone; pfam03477 637910002313 HMMPfam hit to PF03477, ATP-cone, score 4.2e-35 637910002314 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 637910002315 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 637910002316 catalytic motif [active] 637910002317 Zn binding site [ion binding]; other site 637910002318 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 637910002319 HMMPfam hit to PF00383, CMP/dCMP deaminase, zinc-binding, score 1.2e-45 637910002320 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 637910002321 HMMPfam hit to PF01872, Bacterial bifunctional deaminase-reductase, C-terminal, score 3.8e-89 637910002322 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 637910002323 homopentamer interface [polypeptide binding]; other site 637910002324 active site 637910002325 HMMPfam hit to PF00885, 6,7-dimethyl-8-ribityllumazine synthase, score 5.4e-92 637910002326 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 637910002327 putative RNA binding site [nucleotide binding]; other site 637910002328 HMMPfam hit to PF01029, NusB/RsmB/TIM44, score 1.8e-49 637910002329 thiamine monophosphate kinase; Provisional; Region: PRK05731 637910002330 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 637910002331 ATP binding site [chemical binding]; other site 637910002332 dimerization interface [polypeptide binding]; other site 637910002333 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 3.4e-05 637910002334 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 637910002335 tetramer interfaces [polypeptide binding]; other site 637910002336 binuclear metal-binding site [ion binding]; other site 637910002337 3 transmembrane helices predicted for ROD04671 by TMHMM2.0 at aa 21-43, 53-75 and 149-168 637910002338 HMMPfam hit to PF04608, Phosphatidylglycerophosphatase A, score 4.1e-78 637910002339 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637910002340 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637910002341 active site 637910002342 catalytic tetrad [active] 637910002343 HMMPfam hit to PF00248, Aldo/keto reductase, score 2.4e-66 637910002344 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 637910002345 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 637910002346 TPP-binding site; other site 637910002347 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637910002348 PYR/PP interface [polypeptide binding]; other site 637910002349 dimer interface [polypeptide binding]; other site 637910002350 TPP binding site [chemical binding]; other site 637910002351 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637910002352 HMMPfam hit to PF02780, Transketolase, C-terminal, score 5e-39 637910002353 HMMPfam hit to PF02779, Transketolase, central region, score 2.2e-59 637910002354 PS00802 Transketolase signature 2. 637910002355 PS00801 Transketolase signature 1. 637910002356 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 637910002357 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 637910002358 substrate binding pocket [chemical binding]; other site 637910002359 chain length determination region; other site 637910002360 substrate-Mg2+ binding site; other site 637910002361 catalytic residues [active] 637910002362 aspartate-rich region 1; other site 637910002363 active site lid residues [active] 637910002364 aspartate-rich region 2; other site 637910002365 HMMPfam hit to PF00348, Polyprenyl synthetase, score 1e-131 637910002366 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002367 PS00444 Polyprenyl synthetases signature 2. 637910002368 PS00723 Polyprenyl synthetases signature 1. 637910002369 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 637910002370 HMMPfam hit to PF02609, Exonuclease VII, small subunit, score 3.4e-32 637910002371 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 637910002372 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 637910002373 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 637910002374 Ligand Binding Site [chemical binding]; other site 637910002375 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 637910002376 active site residue [active] 637910002377 HMMPfam hit to PF02926, THUMP, score 2.2e-28 637910002378 HMMPfam hit to PF02568, Thiamine biosynthesis protein, score 3.4e-112 637910002379 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 637910002380 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 637910002381 conserved cys residue [active] 637910002382 HMMPfam hit to PF01965, ThiJ/PfpI, score 4.4e-46 637910002383 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 637910002384 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 637910002385 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 637910002386 HMMPfam hit to PF08546, Ketopantoate reductase ApbA/PanE, C-terminal, score 1.5e-57 637910002387 HMMPfam hit to PF02558, Ketopantoate reductase ApbA/PanE, N-terminal, score 5.2e-38 637910002388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 637910002389 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 637910002390 HMMPfam hit to PF04461, Protein of unknown function DUF520, score 5.3e-114 637910002391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910002392 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637910002393 putative substrate translocation pore; other site 637910002394 12 transmembrane helices predicted for ROD04761 by TMHMM2.0 at aa 13-35, 50-72, 79-98, 102-124, 137-159, 164-186, 214-236, 251-273, 280-302, 306-328, 341-363 and 368-385 637910002395 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 9.7e-48 637910002396 benzoate transport; Region: 2A0115; TIGR00895 637910002397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910002398 putative substrate translocation pore; other site 637910002399 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002400 11 transmembrane helices predicted for ROD04771 by TMHMM2.0 at aa 24-46, 61-83, 90-112, 116-138, 150-172, 177-199, 255-277, 292-314, 326-348, 385-407 and 414-436 637910002401 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 9.8e-53 637910002402 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002403 PS00217 Sugar transport proteins signature 2. 637910002404 PS00216 Sugar transport proteins signature 1. 637910002405 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 637910002406 HMMPfam hit to PF01261, Xylose isomerase-type TIM barrel, score 5.2e-30 637910002407 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 637910002408 Predicted oxidoreductase [General function prediction only]; Region: COG3573 637910002409 HMMPfam hit to PF00890, Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal, score 1.1e-182 637910002410 NIPSNAP; Region: NIPSNAP; pfam07978 637910002411 HMMPfam hit to PF07978, NIPSNAP, score 1.8e-39 637910002412 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910002413 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 637910002414 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 637910002415 HMMPfam hit to PF00890, Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal, score 2.5e-159 637910002416 Predicted helix-turn-helix motif with score 1025.000, SD 2.68 at aa 416-437, sequence ESLSALAQQLDIDPQQLEQTVA 637910002417 1 transmembrane helix predicted for ROD04811 by TMHMM2.0 at aa 7-29 637910002418 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002419 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 637910002420 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 637910002421 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 637910002422 shikimate binding site; other site 637910002423 NAD(P) binding site [chemical binding]; other site 637910002424 HMMPfam hit to PF01488, Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase, score 0.00021 637910002425 HMMPfam hit to PF08501, Shikimate dehydrogenase substrate-binding, N-terminal, score 5.3e-23 637910002426 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 637910002427 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 637910002428 Bacterial transcriptional regulator; Region: IclR; pfam01614 637910002429 HMMPfam hit to PF09339, Transcriptional regulator IclR, N-terminal, score 2.4e-19 637910002430 Predicted helix-turn-helix motif with score 1169.000, SD 3.17 at aa 31-52, sequence LTVPQAAKMSGLTQSAARRFFL 637910002431 HMMPfam hit to PF01614, Transcriptional regulator IclR, C-terminal, score 2.6e-16 637910002432 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 637910002433 UbiA prenyltransferase family; Region: UbiA; pfam01040 637910002434 9 transmembrane helices predicted for ROD04841 by TMHMM2.0 at aa 12-34, 38-60, 80-102, 107-126, 133-155, 160-182, 209-231, 235-252 and 264-286 637910002435 HMMPfam hit to PF01040, UbiA prenyltransferase, score 5.2e-90 637910002436 PS00943 UbiA prenyltransferase family signature. 637910002437 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002438 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 637910002439 HMMPfam hit to PF03626, Cytochrome C oxidase subunit IV prokaryotic, score 5e-52 637910002440 3 transmembrane helices predicted for ROD04842 by TMHMM2.0 at aa 15-37, 44-66 and 76-98 637910002441 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 637910002442 Subunit I/III interface [polypeptide binding]; other site 637910002443 Subunit III/IV interface [polypeptide binding]; other site 637910002444 HMMPfam hit to PF00510, Cytochrome c oxidase, subunit III, score 4.1e-06 637910002445 5 transmembrane helices predicted for ROD04851 by TMHMM2.0 at aa 26-48, 63-85, 98-118, 138-160 and 181-203 637910002446 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 637910002447 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 637910002448 D-pathway; other site 637910002449 Putative ubiquinol binding site [chemical binding]; other site 637910002450 Low-spin heme (heme b) binding site [chemical binding]; other site 637910002451 Putative water exit pathway; other site 637910002452 Binuclear center (heme o3/CuB) [ion binding]; other site 637910002453 K-pathway; other site 637910002454 Putative proton exit pathway; other site 637910002455 14 transmembrane helices predicted for ROD04861 by TMHMM2.0 at aa 15-37, 57-79, 105-127, 140-162, 191-213, 233-255, 275-297, 310-332, 347-369, 382-404, 414-436, 457-479, 494-516 and 590-612 637910002456 HMMPfam hit to PF00115, Cytochrome c oxidase, subunit I, score 1.5e-268 637910002457 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002458 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 637910002459 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 637910002460 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 637910002461 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 637910002462 HMMPfam hit to PF06481, COX aromatic rich, score 1.2e-17 637910002463 HMMPfam hit to PF00116, Cytochrome c oxidase subunit II C-terminal, score 8.5e-06 637910002464 3 transmembrane helices predicted for ROD04871 by TMHMM2.0 at aa 12-30, 45-67 and 88-110 637910002465 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002466 muropeptide transporter; Reviewed; Region: ampG; PRK11902 637910002467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910002468 putative substrate translocation pore; other site 637910002469 14 transmembrane helices predicted for ROD04881 by TMHMM2.0 at aa 17-39, 49-70, 83-105, 110-132, 145-167, 177-196, 224-246, 261-283, 288-310, 320-342, 355-377, 381-403, 433-455 and 459-481 637910002470 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 4.2e-29 637910002471 hypothetical protein; Provisional; Region: PRK11627 637910002472 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 637910002473 HMMPfam hit to PF03923, Uncharacterized lipoprotein, score 4.2e-07 637910002474 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002475 transcriptional regulator BolA; Provisional; Region: PRK11628 637910002476 HMMPfam hit to PF01722, BolA-like protein, score 4.7e-39 637910002477 trigger factor; Provisional; Region: tig; PRK01490 637910002478 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 637910002479 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 637910002480 HMMPfam hit to PF05697, Bacterial trigger factor, N-terminal, score 7.6e-70 637910002481 HMMPfam hit to PF00254, Peptidyl-prolyl cis-trans isomerase, FKBP-type, score 4.7e-27 637910002482 HMMPfam hit to PF05698, Bacterial trigger factor, C-terminal, score 6.7e-61 637910002483 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 637910002484 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 637910002485 oligomer interface [polypeptide binding]; other site 637910002486 active site residues [active] 637910002487 HMMPfam hit to PF00574, Peptidase S14, ClpP, score 8e-140 637910002488 PS00381 Endopeptidase Clp serine active site. 637910002489 PS00382 Endopeptidase Clp histidine active site. 637910002490 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 637910002491 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 637910002492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910002493 Walker A motif; other site 637910002494 ATP binding site [chemical binding]; other site 637910002495 Walker B motif; other site 637910002496 Iron permease FTR1 family; Region: FTR1; cl00475 637910002497 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 637910002498 HMMPfam hit to PF06689, Zinc finger, C4-type, score 5e-27 637910002499 HMMPfam hit to PF07724, ATPase AAA-2, score 4.7e-81 637910002500 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002501 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 637910002502 Found in ATP-dependent protease La (LON); Region: LON; smart00464 637910002503 Found in ATP-dependent protease La (LON); Region: LON; smart00464 637910002504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910002505 Walker A motif; other site 637910002506 ATP binding site [chemical binding]; other site 637910002507 Walker B motif; other site 637910002508 arginine finger; other site 637910002509 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 637910002510 HMMPfam hit to PF02190, Peptidase S16, lon N-terminal, score 2.6e-84 637910002511 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 637910002512 HMMPfam hit to PF00004, AAA ATPase, core, score 1.1e-44 637910002513 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002514 HMMPfam hit to PF05362, Peptidase S16, lon C-terminal, score 4.9e-158 637910002515 PS01046 ATP-dependent serine proteases, lon family, serine active site. 637910002516 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002517 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 637910002518 IHF dimer interface [polypeptide binding]; other site 637910002519 IHF - DNA interface [nucleotide binding]; other site 637910002520 HMMPfam hit to PF00216, Histone-like bacterial DNA-binding protein, score 8.4e-48 637910002521 PS00045 Bacterial histone-like DNA-binding proteins signature. 637910002522 periplasmic folding chaperone; Provisional; Region: PRK10788 637910002523 SurA N-terminal domain; Region: SurA_N_3; cl07813 637910002524 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 637910002525 1 transmembrane helix predicted for ROD04961 by TMHMM2.0 at aa 13-35 637910002526 HMMPfam hit to PF00639, Peptidyl-prolyl cis-trans isomerase, PpiC-type, score 6.3e-17 637910002527 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 637910002528 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 637910002529 1 transmembrane helix predicted for ROD04971 by TMHMM2.0 at aa 7-29 637910002530 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 637910002531 active site 637910002532 HMMPfam hit to PF03061, Thioesterase superfamily, score 3.1e-15 637910002533 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 637910002534 Ligand Binding Site [chemical binding]; other site 637910002535 HMMPfam hit to PF06508, Exoenzyme S synthesis protein B/queuosine synthesis, score 5.8e-113 637910002536 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 637910002537 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 637910002538 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 637910002539 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 2.3e-20 637910002540 Predicted helix-turn-helix motif with score 1278.000, SD 3.54 at aa 24-45, sequence VTVSKLAERCFCSERHIRTLLR 637910002541 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 637910002542 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910002543 active site 637910002544 motif I; other site 637910002545 motif II; other site 637910002546 PS01228 Hypothetical cof family signature 1. 637910002547 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 6.9e-63 637910002548 PS01229 Hypothetical cof family signature 2. 637910002549 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 637910002550 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 637910002551 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637910002552 catalytic residue [active] 637910002553 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 9.5e-57 637910002554 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 637910002555 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637910002556 putative DNA binding site [nucleotide binding]; other site 637910002557 putative Zn2+ binding site [ion binding]; other site 637910002558 AsnC family; Region: AsnC_trans_reg; pfam01037 637910002559 Predicted helix-turn-helix motif with score 1276.000, SD 3.53 at aa 19-40, sequence LSLQALADAVNLTTTPCWKRLK 637910002560 PS00519 Bacterial regulatory proteins, asnC family signature. 637910002561 HMMPfam hit to PF01037, Bacterial regulatory proteins, AsnC/Lrp, score 6.5e-29 637910002562 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 637910002563 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637910002564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910002565 Walker A/P-loop; other site 637910002566 ATP binding site [chemical binding]; other site 637910002567 Q-loop/lid; other site 637910002568 ABC transporter signature motif; other site 637910002569 Walker B; other site 637910002570 D-loop; other site 637910002571 H-loop/switch region; other site 637910002572 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 4.1e-31 637910002573 6 transmembrane helices predicted for ROD05031 by TMHMM2.0 at aa 21-43, 58-77, 129-151, 156-175, 246-268 and 278-300 637910002574 HMMPfam hit to PF00005, ABC transporter related, score 3e-55 637910002575 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002576 PS00211 ABC transporters family signature. 637910002577 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 637910002578 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637910002579 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910002580 Walker A/P-loop; other site 637910002581 ATP binding site [chemical binding]; other site 637910002582 Q-loop/lid; other site 637910002583 ABC transporter signature motif; other site 637910002584 Walker B; other site 637910002585 D-loop; other site 637910002586 H-loop/switch region; other site 637910002587 5 transmembrane helices predicted for ROD05041 by TMHMM2.0 at aa 24-46, 61-83, 138-160, 165-185 and 249-271 637910002588 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 7.1e-30 637910002589 HMMPfam hit to PF00005, ABC transporter related, score 4.8e-43 637910002590 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002591 PS00211 ABC transporters family signature. 637910002592 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 637910002593 Nitrogen regulatory protein P-II; Region: P-II; smart00938 637910002594 HMMPfam hit to PF00543, Nitrogen regulatory protein PII, score 1.6e-72 637910002595 PS00496 P-II protein urydylation site. 637910002596 PS00638 P-II protein C-terminal region signature. 637910002597 ammonium transporter; Provisional; Region: PRK10666 637910002598 12 transmembrane helices predicted for ROD05061 by TMHMM2.0 at aa 7-26, 36-58, 63-85, 120-142, 149-171, 186-205, 218-237, 247-269, 281-303, 307-324, 337-359 and 374-396 637910002599 HMMPfam hit to PF00909, Rh-like protein/ammonium transporter score 1.1e-188 637910002600 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002601 PS01219 Ammonium transporters signature. 637910002602 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002603 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002604 acyl-CoA thioesterase II; Provisional; Region: PRK10526 637910002605 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 637910002606 active site 637910002607 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 637910002608 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 637910002609 catalytic triad [active] 637910002610 dimer interface [polypeptide binding]; other site 637910002611 HMMPfam hit to PF02551, Acyl-CoA thioesterase, score 3.4e-75 637910002612 HMMPfam hit to PF02551, Acyl-CoA thioesterase, score 5.3e-43 637910002613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 637910002614 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002615 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 637910002616 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 637910002617 DNA binding site [nucleotide binding] 637910002618 active site 637910002619 HMMPfam hit to PF01035, Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding, score 2.8e-42 637910002620 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 637910002621 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 637910002622 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637910002623 HMMPfam hit to PF00563, EAL, score 9.4e-110 637910002624 2 transmembrane helices predicted for ROD05121 by TMHMM2.0 at aa 6-28 and 243-265 637910002625 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 637910002626 2 transmembrane helices predicted for ROD05131 by TMHMM2.0 at aa 30-52 and 62-79 637910002627 maltose O-acetyltransferase; Provisional; Region: PRK10092 637910002628 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 637910002629 active site 637910002630 substrate binding site [chemical binding]; other site 637910002631 trimer interface [polypeptide binding]; other site 637910002632 CoA binding site [chemical binding]; other site 637910002633 PS00101 Hexapeptide-repeat containing-transferases signature. 637910002634 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.098 637910002635 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.17 637910002636 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.048 637910002637 gene expression modulator; Provisional; Region: PRK10945 637910002638 HMMPfam hit to PF05321, Haemolysin expression modulating, score 3e-37 637910002639 Hha toxicity attenuator; Provisional; Region: PRK10667 637910002640 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 637910002641 Protein export membrane protein; Region: SecD_SecF; cl14618 637910002642 Protein export membrane protein; Region: SecD_SecF; cl14618 637910002643 HMMPfam hit to PF00873, Acriflavin resistance protein, score 0 637910002644 11 transmembrane helices predicted for ROD05171 by TMHMM2.0 at aa 10-32, 340-359, 369-391, 438-460, 470-492, 542-564, 873-892, 899-921, 926-948, 975-997 and 1007-1029 637910002645 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002646 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 637910002647 HlyD family secretion protein; Region: HlyD_3; pfam13437 637910002648 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 637910002649 substrate binding site [chemical binding]; other site 637910002650 HMMPfam hit to PF00529, Secretion protein HlyD, score 1.3e-94 637910002651 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002652 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 637910002653 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637910002654 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 637910002655 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 2.6e-24 637910002656 PS01081 Bacterial regulatory proteins, tetR family signature. 637910002657 Predicted helix-turn-helix motif with score 2353.000, SD 7.20 at aa 32-53, sequence TSLAEIAKAAGVTRGAIYWHFK 637910002658 HMMPfam hit to PF08361, Transcriptional regulator, MAATS, C-terminal, score 7.5e-85 637910002659 hypothetical protein; Provisional; Region: PRK11281 637910002660 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 637910002661 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 637910002662 Mechanosensitive ion channel; Region: MS_channel; pfam00924 637910002663 12 transmembrane helices predicted for ROD05201 by TMHMM2.0 at aa 13-35, 500-522, 557-579, 584-606, 630-647, 657-676, 689-711, 726-748, 796-818, 841-860, 881-903 and 918-940 637910002664 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002665 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 1.5e-89 637910002666 PS01246 Uncharacterized protein family UPF0003 signature. 637910002667 pseudogene, disrupted by IS102 insertion 637910002668 HMMPfam hit to PF04754, Transposase (), YhgA-like, score 1.2e-155 637910002669 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 637910002670 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910002671 HMMPfam hit to PF01609, Transposase, IS4-like, score 9.3e-30 637910002672 hypothetical protein; Provisional; Region: PRK11038 637910002673 primosomal replication protein N''; Provisional; Region: PRK10093 637910002674 HMMPfam hit to PF07445, Primosomal replication priB and priC, score 6.8e-77 637910002675 hypothetical protein; Provisional; Region: PRK10527 637910002676 3 transmembrane helices predicted for ROD05261 by TMHMM2.0 at aa 10-32, 81-98 and 102-124 637910002677 HMMPfam hit to PF04304, Protein of unknown function DUF454, score 3.3e-31 637910002678 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637910002679 active site 637910002680 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 6.4e-50 637910002681 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 637910002682 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 637910002683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910002684 Walker A motif; other site 637910002685 ATP binding site [chemical binding]; other site 637910002686 Walker B motif; other site 637910002687 DNA polymerase III subunit delta'; Validated; Region: PRK08485 637910002688 arginine finger; other site 637910002689 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 637910002690 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 637910002691 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 637910002692 HMMPfam hit to PF00004, AAA ATPase, core, score 5.6e-11 637910002693 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002694 hypothetical protein; Validated; Region: PRK00153 637910002695 HMMPfam hit to PF02575, Conserved hypothetical protein CHP00103, score 2.7e-52 637910002696 recombination protein RecR; Reviewed; Region: recR; PRK00076 637910002697 RecR protein; Region: RecR; pfam02132 637910002698 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 637910002699 putative active site [active] 637910002700 putative metal-binding site [ion binding]; other site 637910002701 tetramer interface [polypeptide binding]; other site 637910002702 HMMPfam hit to PF02132, Zinc finger C4-type, RecR, score 3.4e-22 637910002703 PS01300 RecR protein signature. 637910002704 HMMPfam hit to PF01751, TOPRIM, score 1.3e-22 637910002705 heat shock protein 90; Provisional; Region: PRK05218 637910002706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910002707 ATP binding site [chemical binding]; other site 637910002708 Mg2+ binding site [ion binding]; other site 637910002709 G-X-G motif; other site 637910002710 PS00298 Heat shock hsp90 proteins family signature. 637910002711 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.2e-17 637910002712 HMMPfam hit to PF00183, Heat shock protein Hsp90, score 1.5e-114 637910002713 adenylate kinase; Reviewed; Region: adk; PRK00279 637910002714 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 637910002715 AMP-binding site [chemical binding]; other site 637910002716 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 637910002717 HMMPfam hit to PF00406, Adenylate kinase, score 6.1e-100 637910002718 PS00113 Adenylate kinase signature. 637910002719 HMMPfam hit to PF05191, Adenylate kinase, lid region, score 1.5e-21 637910002720 ferrochelatase; Reviewed; Region: hemH; PRK00035 637910002721 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 637910002722 C-terminal domain interface [polypeptide binding]; other site 637910002723 active site 637910002724 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 637910002725 active site 637910002726 N-terminal domain interface [polypeptide binding]; other site 637910002727 HMMPfam hit to PF00762, Ferrochelatase, score 6.1e-158 637910002728 PS00534 Ferrochelatase signature. 637910002729 acetyl esterase; Provisional; Region: PRK10162 637910002730 HMMPfam hit to PF07859, Alpha/beta hydrolase fold-3, score 7.9e-71 637910002731 PS01174 Lipolytic enzymes G-D-X-G family, serine active site. 637910002732 PS01173 Lipolytic enzymes G-D-X-G family, histidine active site. 637910002733 inosine/guanosine kinase; Provisional; Region: PRK15074 637910002734 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 637910002735 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 7.9e-23 637910002736 PS00584 pfkB family of carbohydrate kinases signature 2. 637910002737 putative cation:proton antiport protein; Provisional; Region: PRK10669 637910002738 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 637910002739 TrkA-N domain; Region: TrkA_N; pfam02254 637910002740 HMMPfam hit to PF02254, TrkA-N, score 2e-33 637910002741 11 transmembrane helices predicted for ROD05361 by TMHMM2.0 at aa 4-26, 33-52, 56-78, 87-109, 114-136, 149-171, 191-213, 226-248, 302-324, 336-358 and 368-387 637910002742 HMMPfam hit to PF00999, Sodium/hydrogen exchanger, score 2e-88 637910002743 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910002745 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637910002746 putative substrate translocation pore; other site 637910002747 10 transmembrane helices predicted for ROD05371 by TMHMM2.0 at aa 26-48, 58-80, 101-123, 180-202, 223-245, 265-287, 294-313, 317-339, 351-373 and 377-399 637910002748 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.1e-39 637910002749 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 637910002750 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 637910002751 active site 637910002752 metal binding site [ion binding]; metal-binding site 637910002753 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 637910002754 HMMPfam hit to PF00149, Metallophosphoesterase, score 7.6e-18 637910002755 PS00785 5'-nucleotidase signature 1. 637910002756 PS00786 5'-nucleotidase signature 2. 637910002757 HMMPfam hit to PF02872, 5'-Nucleotidase, C-terminal, score 1.4e-56 637910002758 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 637910002759 putative deacylase active site [active] 637910002760 HMMPfam hit to PF04073, YbaK/prolyl-tRNA synthetase associated region, score 1.3e-77 637910002761 TraB family; Region: TraB; cl12050 637910002762 HMMPfam hit to PF07446, GumN, score 4.8e-07 637910002763 copper exporting ATPase; Provisional; Region: copA; PRK10671 637910002764 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637910002765 metal-binding site [ion binding] 637910002766 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637910002767 metal-binding site [ion binding] 637910002768 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637910002769 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910002770 active site 637910002771 motif I; other site 637910002772 motif II; other site 637910002773 8 transmembrane helices predicted for ROD05411 by TMHMM2.0 at aa 188-205, 215-237, 244-266, 281-298, 435-457, 462-484, 777-796 and 801-823 637910002774 Predicted helix-turn-helix motif with score 1335.000, SD 3.73 at aa 754-775, sequence HSLLGVADALSLSRATLRNMKQ 637910002775 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 7.7e-41 637910002776 PS01229 Hypothetical cof family signature 2. 637910002777 PS00154 E1-E2 ATPases phosphorylation site. 637910002778 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 1e-97 637910002779 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002780 HMMPfam hit to PF00403, Heavy metal transport/detoxification protein, score 1.5e-15 637910002781 PS01047 Heavy-metal-associated domain. 637910002782 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002783 HMMPfam hit to PF00403, Heavy metal transport/detoxification protein, score 9.1e-12 637910002784 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 637910002785 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 637910002786 DNA binding residues [nucleotide binding] 637910002787 dimer interface [polypeptide binding]; other site 637910002788 copper binding site [ion binding]; other site 637910002789 Predicted helix-turn-helix motif with score 1486.000, SD 4.25 at aa 1-22, sequence MNISDVAKKTGLTSKAIRFYEE 637910002790 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 4.3e-13 637910002791 PS00552 Bacterial regulatory proteins, merR family signature. 637910002792 HMMPfam hit to PF09278, Transcription regulator MerR, DNA binding, score 2.8e-19 637910002793 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 637910002794 HMMPfam hit to PF01957, Nodulation efficiency, NfeD, score 6.1e-35 637910002795 3 transmembrane helices predicted for ROD05431 by TMHMM2.0 at aa 4-23, 30-49 and 53-72 637910002796 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 637910002797 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 637910002798 HMMPfam hit to PF01145, Band 7 protein, score 1.8e-79 637910002799 PS01270 Band 7 protein family signature. 637910002800 1 transmembrane helix predicted for ROD05441 by TMHMM2.0 at aa 7-29 637910002801 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 637910002802 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 637910002803 Walker A/P-loop; other site 637910002804 ATP binding site [chemical binding]; other site 637910002805 Q-loop/lid; other site 637910002806 ABC transporter signature motif; other site 637910002807 Walker B; other site 637910002808 D-loop; other site 637910002809 H-loop/switch region; other site 637910002810 HMMPfam hit to PF00005, ABC transporter related, score 3.9e-42 637910002811 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002812 PS00211 ABC transporters family signature. 637910002813 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 637910002814 HMMPfam hit to PF03649, Conserved hypothetical protein CHP00245, score 4e-158 637910002815 7 transmembrane helices predicted for ROD05461 by TMHMM2.0 at aa 5-24, 36-53, 57-79, 92-114, 124-146, 192-209 and 219-241 637910002816 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002817 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 637910002818 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 637910002819 HMMPfam hit to PF00085, Thioredoxin domain, score 9.6e-22 637910002820 oxidoreductase; Provisional; Region: PRK08017 637910002821 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 637910002822 NADP binding site [chemical binding]; other site 637910002823 active site 637910002824 steroid binding site; other site 637910002825 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 4.6e-23 637910002826 PS00061 Short-chain dehydrogenases/reductases family signature. 637910002827 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 637910002828 active site 637910002829 catalytic triad [active] 637910002830 oxyanion hole [active] 637910002831 switch loop; other site 637910002832 HMMPfam hit to PF00657, Lipolytic enzyme, G-D-S-L, score 5.9e-34 637910002833 PS01098 Lipolytic enzymes G-D-S-L family, serine active site. 637910002834 1 transmembrane helix predicted for ROD05491 by TMHMM2.0 at aa 12-34 637910002835 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 637910002836 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637910002837 Walker A/P-loop; other site 637910002838 ATP binding site [chemical binding]; other site 637910002839 Q-loop/lid; other site 637910002840 ABC transporter signature motif; other site 637910002841 Walker B; other site 637910002842 D-loop; other site 637910002843 H-loop/switch region; other site 637910002844 HMMPfam hit to PF00005, ABC transporter related, score 7.8e-60 637910002845 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002846 PS00211 ABC transporters family signature. 637910002847 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 637910002848 FtsX-like permease family; Region: FtsX; pfam02687 637910002849 10 transmembrane helices predicted for ROD05511 by TMHMM2.0 at aa 13-35, 243-262, 291-313, 333-355, 376-398, 403-425, 451-473, 676-698, 732-754 and 769-791 637910002850 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002851 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 6.3e-14 637910002852 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 9.6e-08 637910002853 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002854 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 637910002855 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 637910002856 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 637910002857 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 637910002858 active site residue [active] 637910002859 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002860 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 637910002861 ATP-grasp domain; Region: ATP-grasp; pfam02222 637910002862 HMMPfam hit to PF02222, ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type, score 7.7e-93 637910002863 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 637910002864 HMMPfam hit to PF00731, 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase, score 5.8e-107 637910002865 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 637910002866 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637910002867 putative active site [active] 637910002868 putative metal binding site [ion binding]; other site 637910002869 HMMPfam hit to PF00149, Metallophosphoesterase, score 3e-14 637910002870 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 637910002871 substrate binding site [chemical binding]; other site 637910002872 HMMPfam hit to PF00160, Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, score 6.3e-53 637910002873 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 637910002874 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 637910002875 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 637910002876 active site 637910002877 HIGH motif; other site 637910002878 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 637910002879 KMSKS motif; other site 637910002880 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 637910002881 tRNA binding surface [nucleotide binding]; other site 637910002882 anticodon binding site; other site 637910002883 HMMPfam hit to PF01406, Cysteinyl-tRNA synthetase, class Ia, N-terminal, score 8.9e-226 637910002884 HMMPfam hit to PF09190, Cysteinyl-tRNA synthetase, class Ia, DALR, score 7.3e-35 637910002885 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 637910002886 HMMPfam hit to PF04307, Protein of unknown function DUF457, transmembrane, score 3e-32 637910002887 2 transmembrane helices predicted for ROD05591 by TMHMM2.0 at aa 13-35 and 55-77 637910002888 ribosome-associated protein; Provisional; Region: PRK11507 637910002889 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 637910002890 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 637910002891 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 637910002892 homodimer interface [polypeptide binding]; other site 637910002893 NADP binding site [chemical binding]; other site 637910002894 substrate binding site [chemical binding]; other site 637910002895 HMMPfam hit to PF02882, Tetrahydrofolate dehydrogenase/cyclohydrolase, score 7e-108 637910002896 PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. 637910002897 HMMPfam hit to PF00763, Tetrahydrofolate dehydrogenase/cyclohydrolase, score 1.9e-72 637910002898 PS00766 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. 637910002899 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002900 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 637910002901 HMMPfam hit to PF04519, Protein of unknown function DUF583, score 6.7e-19 637910002902 Predicted helix-turn-helix motif with score 989.000, SD 2.56 at aa 75-96, sequence DSQADISIASSLNPSQVSYLGD 637910002903 2 transmembrane helices predicted for ROD05631 by TMHMM2.0 at aa 5-22 and 37-59 637910002904 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 637910002905 pseudogene, truncated by premature stop codon 637910002906 HMMPfam hit to PF00324, Amino acid permease-associated region, score 1.7e-149 637910002907 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 637910002908 Mechanosensitive ion channel; Region: MS_channel; pfam00924 637910002909 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 1.7e-61 637910002910 5 transmembrane helices predicted for ROD05671 by TMHMM2.0 at aa 23-45, 68-90, 105-127, 140-162 and 172-194 637910002911 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 637910002912 dimer interface [polypeptide binding]; other site 637910002913 FMN binding site [chemical binding]; other site 637910002914 HMMPfam hit to PF00881, Nitroreductase, score 8.6e-74 637910002915 hypothetical protein; Provisional; Region: PRK10250 637910002916 HMMPfam hit to PF04237, Protein of unknown function DUF419, score 1.6e-43 637910002917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637910002918 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 5.9e-13 637910002919 PS01081 Bacterial regulatory proteins, tetR family signature. 637910002920 Predicted helix-turn-helix motif with score 1289.000, SD 3.58 at aa 28-49, sequence ASTAAIARSAGVAEGTLFRYFA 637910002921 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 637910002922 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910002923 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.6e-11 637910002924 Predicted helix-turn-helix motif with score 1267.000, SD 3.50 at aa 23-44, sequence LRIDDIARHAGYSKWHLQRLFM 637910002925 PS00041 Bacterial regulatory proteins, araC family signature. 637910002926 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 4.1e-10 637910002927 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 637910002928 HMMPfam hit to PF06643, Protein of unknown function DUF1158, score 8e-58 637910002929 2 transmembrane helices predicted for ROD05721 by TMHMM2.0 at aa 13-35 and 50-72 637910002930 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002931 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 637910002932 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 637910002933 HMMPfam hit to PF04107, glutamate--cysteine ligase, GCS2, score 2.1e-115 637910002934 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637910002935 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 637910002936 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.1e-07 637910002937 pseudogene, disrupted by ISEc14 insertion and an internal deletion. ROD38701 is an intact copy of this transposase, and is also found adjacent to NleD 637910002938 putative transposase OrfB; Reviewed; Region: PHA02517 637910002939 HTH-like domain; Region: HTH_21; pfam13276 637910002940 Integrase core domain; Region: rve; pfam00665 637910002941 Integrase core domain; Region: rve_3; pfam13683 637910002942 HMMPfam hit to PF00665, Integrase, catalytic core, score 1.3e-45 637910002943 PS00501 Signal peptidases I serine active site. 637910002944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910002945 Transposase; Region: HTH_Tnp_1; pfam01527 637910002946 HMMPfam hit to PF01527, Transposase IS3/IS911, score 5.2e-23 637910002947 Predicted helix-turn-helix motif with score 1681.000, SD 4.91 at aa 23-44, sequence YSVAEVSDRLGVSAHSLYKWLR 637910002948 HMMPfam hit to PF01610, Transposase, IS204/IS1001/IS1096/IS1165, score 3.2e-32 637910002949 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 637910002950 Hok/gef family; Region: HOK_GEF; pfam01848 637910002951 HMMPfam hit to PF01848, Hok/gef cell toxic protein, score 1.4e-26 637910002952 1 transmembrane helix predicted for ROD05801 by TMHMM2.0 at aa 5-24 637910002953 PS00556 Hok/gef family cell toxic proteins signature. 637910002954 short chain dehydrogenase; Provisional; Region: PRK06114 637910002955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637910002956 NAD(P) binding site [chemical binding]; other site 637910002957 active site 637910002958 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 1.6e-30 637910002959 PS00061 Short-chain dehydrogenases/reductases family signature. 637910002960 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 637910002961 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 637910002962 NAD binding site [chemical binding]; other site 637910002963 homotetramer interface [polypeptide binding]; other site 637910002964 homodimer interface [polypeptide binding]; other site 637910002965 active site 637910002966 substrate binding site [chemical binding]; other site 637910002967 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 2e-36 637910002968 PS00061 Short-chain dehydrogenases/reductases family signature. 637910002969 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637910002970 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637910002971 TM-ABC transporter signature motif; other site 637910002972 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 1.7e-61 637910002973 8 transmembrane helices predicted for ROD05831 by TMHMM2.0 at aa 17-36, 41-63, 70-92, 97-119, 126-148, 174-196, 228-250 and 282-304 637910002974 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637910002975 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637910002976 Walker A/P-loop; other site 637910002977 ATP binding site [chemical binding]; other site 637910002978 Q-loop/lid; other site 637910002979 ABC transporter signature motif; other site 637910002980 Walker B; other site 637910002981 D-loop; other site 637910002982 H-loop/switch region; other site 637910002983 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637910002984 HMMPfam hit to PF00005, ABC transporter related, score 3.2e-24 637910002985 PS00211 ABC transporters family signature. 637910002986 HMMPfam hit to PF00005, ABC transporter related, score 6.3e-45 637910002987 PS00017 ATP/GTP-binding site motif A (P-loop). 637910002988 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 637910002989 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910002990 pseudogene, truncated by frameshift mutation 637910002991 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 1e-07 637910002992 pseudogene, truncated by premature stop codon 637910002993 HMMPfam hit to PF02782, Carbohydrate kinase, FGGY, score 5.7e-49 637910002994 HMMPfam hit to PF00370, Carbohydrate kinase, FGGY, score 2.6e-72 637910002995 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 637910002996 MarR family; Region: MarR_2; cl17246 637910002997 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 637910002998 HMMPfam hit to PF04198, sugar-binding region, score 1.1e-65 637910002999 Predicted helix-turn-helix motif with score 1966.000, SD 5.88 at aa 22-43, sequence RKQSDIAQLLSLSQSFISRAIS 637910003000 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637910003001 TPP-binding site [chemical binding]; other site 637910003002 dimer interface [polypeptide binding]; other site 637910003003 HMMPfam hit to PF00456, Transketolase, N-terminal, score 2.9e-34 637910003004 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 637910003005 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637910003006 PYR/PP interface [polypeptide binding]; other site 637910003007 dimer interface [polypeptide binding]; other site 637910003008 TPP binding site [chemical binding]; other site 637910003009 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637910003010 HMMPfam hit to PF02779, Transketolase, central region, score 1.8e-19 637910003011 HMMPfam hit to PF02780, Transketolase, C-terminal, score 1.6e-24 637910003012 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 637910003013 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 637910003014 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase, score 2.7e-06 637910003015 outer membrane receptor FepA; Provisional; Region: PRK13524 637910003016 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637910003017 N-terminal plug; other site 637910003018 ligand-binding site [chemical binding]; other site 637910003019 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 1.2e-32 637910003020 PS01156 TonB-dependent receptor proteins signature 2. 637910003021 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003022 HMMPfam hit to PF07715, TonB-dependent receptor, plug, score 1.3e-29 637910003023 PS00430 TonB-dependent receptor proteins signature 1. 637910003024 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 637910003025 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 637910003026 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 637910003027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 637910003028 HMMPfam hit to PF00756, esterase, score 1.4e-62 637910003029 HMMPfam hit to PF03621, MbtH-like protein, score 5.9e-30 637910003030 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 637910003031 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 637910003032 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 637910003033 acyl-activating enzyme (AAE) consensus motif; other site 637910003034 AMP binding site [chemical binding]; other site 637910003035 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 637910003036 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 637910003037 HMMPfam hit to PF00668, Condensation domain, score 3e-60 637910003038 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 4.6e-159 637910003039 PS00455 AMP-binding domain signature. 637910003040 HMMPfam hit to PF00550, Phosphopantetheine-binding, score 3.6e-13 637910003041 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003042 PS00012 Phosphopantetheine attachment site. 637910003043 HMMPfam hit to PF00975, Thioesterase, score 6e-52 637910003044 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 637910003045 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637910003046 Walker A/P-loop; other site 637910003047 ATP binding site [chemical binding]; other site 637910003048 Q-loop/lid; other site 637910003049 ABC transporter signature motif; other site 637910003050 Walker B; other site 637910003051 D-loop; other site 637910003052 H-loop/switch region; other site 637910003053 HMMPfam hit to PF00005, ABC transporter related, score 5.5e-54 637910003054 PS00211 ABC transporters family signature. 637910003055 PS00017 ATP/GTP-binding site motif A (P-loop). 637910003056 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 637910003057 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637910003058 ABC-ATPase subunit interface; other site 637910003059 dimer interface [polypeptide binding]; other site 637910003060 putative PBP binding regions; other site 637910003061 HMMPfam hit to PF01032, Bacterial transport system permease, score 1.3e-133 637910003062 8 transmembrane helices predicted for ROD05981 by TMHMM2.0 at aa 7-29, 58-80, 93-112, 116-138, 145-167, 194-211, 240-262 and 302-324 637910003063 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003064 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 637910003065 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637910003066 ABC-ATPase subunit interface; other site 637910003067 dimer interface [polypeptide binding]; other site 637910003068 putative PBP binding regions; other site 637910003069 HMMPfam hit to PF01032, Bacterial transport system permease, score 8e-135 637910003070 9 transmembrane helices predicted for ROD05991 by TMHMM2.0 at aa 10-32, 65-84, 94-116, 121-140, 150-172, 193-215, 240-262, 282-304 and 308-326 637910003071 enterobactin exporter EntS; Provisional; Region: PRK10489 637910003072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910003073 putative substrate translocation pore; other site 637910003074 10 transmembrane helices predicted for ROD06001 by TMHMM2.0 at aa 22-44, 54-76, 111-133, 148-170, 177-199, 214-236, 260-282, 302-324, 345-367 and 377-399 637910003075 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.1e-23 637910003076 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003077 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 637910003078 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 637910003079 siderophore binding site; other site 637910003080 HMMPfam hit to PF01497, Periplasmic binding protein, score 1.1e-58 637910003081 isochorismate synthase EntC; Provisional; Region: PRK15016 637910003082 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 637910003083 HMMPfam hit to PF00425, Chorismate binding, C-terminal, score 1.3e-111 637910003084 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 637910003085 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 637910003086 acyl-activating enzyme (AAE) consensus motif; other site 637910003087 active site 637910003088 AMP binding site [chemical binding]; other site 637910003089 substrate binding site [chemical binding]; other site 637910003090 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 1.9e-105 637910003091 PS00455 AMP-binding domain signature. 637910003092 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 637910003093 hydrophobic substrate binding pocket; other site 637910003094 Isochorismatase family; Region: Isochorismatase; pfam00857 637910003095 active site 637910003096 conserved cis-peptide bond; other site 637910003097 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 637910003098 HMMPfam hit to PF00857, Isochorismatase hydrolase, score 6e-102 637910003099 HMMPfam hit to PF00550, Phosphopantetheine-binding, score 5.3e-11 637910003100 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 637910003101 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 637910003102 putative NAD(P) binding site [chemical binding]; other site 637910003103 active site 637910003104 PS00017 ATP/GTP-binding site motif A (P-loop). 637910003105 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 7.3e-24 637910003106 PS00061 Short-chain dehydrogenases/reductases family signature. 637910003107 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 637910003108 CoenzymeA binding site [chemical binding]; other site 637910003109 subunit interaction site [polypeptide binding]; other site 637910003110 PHB binding site; other site 637910003111 HMMPfam hit to PF03061, Thioesterase superfamily, score 1.2e-22 637910003112 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 637910003113 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 637910003114 metal binding site [ion binding]; metal-binding site 637910003115 dimer interface [polypeptide binding]; other site 637910003116 HMMPfam hit to PF01546, Peptidase M20, score 1e-30 637910003117 HMMPfam hit to PF07687, Peptidase M20, dimerisation, score 2.6e-28 637910003118 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 637910003119 hypothetical protein; Provisional; Region: PRK10519 637910003120 5 transmembrane helices predicted for ROD06081 by TMHMM2.0 at aa 21-40, 45-67, 69-91, 96-118 and 131-153 637910003121 HMMPfam hit to PF07670, Nucleoside recognition, score 9e-10 637910003122 Nucleoside recognition; Region: Gate; pfam07670 637910003123 4 transmembrane helices predicted for ROD06091 by TMHMM2.0 at aa 13-32, 80-102, 168-190 and 195-217 637910003124 HMMPfam hit to PF07670, Nucleoside recognition, score 8.9e-10 637910003125 carbon starvation protein A; Provisional; Region: PRK15015 637910003126 Carbon starvation protein CstA; Region: CstA; pfam02554 637910003127 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 637910003128 18 transmembrane helices predicted for ROD06101 by TMHMM2.0 at aa 7-26, 32-54, 89-111, 116-138, 159-181, 191-213, 218-240, 255-277, 284-306, 326-348, 361-383, 398-420, 441-463, 468-487, 514-533, 548-570, 577-599 and 649-671 637910003129 HMMPfam hit to PF02554, Carbon starvation protein CstA, score 8.9e-297 637910003130 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003131 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003132 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003133 Uncharacterized small protein [Function unknown]; Region: COG2879 637910003134 HMMPfam hit to PF04328, Protein of unknown function DUF466, score 6.9e-44 637910003135 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 637910003136 ParB-like nuclease domain; Region: ParBc; pfam02195 637910003137 HMMPfam hit to PF02195, ParB-like nuclease, score 7.2e-16 637910003138 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 637910003139 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 637910003140 Active Sites [active] 637910003141 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 637910003142 HMMPfam hit to PF01171, PP-loop, score 0.00014 637910003143 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910003144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910003145 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637910003146 dimerization interface [polypeptide binding]; other site 637910003147 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.3e-20 637910003148 PS00044 Bacterial regulatory proteins, lysR family signature. 637910003149 Predicted helix-turn-helix motif with score 1741.000, SD 5.12 at aa 25-46, sequence LSISKAAETLYITPSAVSQSLQ 637910003150 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 637910003151 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 637910003152 dimerization domain [polypeptide binding]; other site 637910003153 dimer interface [polypeptide binding]; other site 637910003154 catalytic residues [active] 637910003155 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 637910003156 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 637910003157 dimer interface [polypeptide binding]; other site 637910003158 decamer (pentamer of dimers) interface [polypeptide binding]; other site 637910003159 catalytic triad [active] 637910003160 peroxidatic and resolving cysteines [active] 637910003161 HMMPfam hit to PF00578, Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen, score 7.5e-40 637910003162 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 637910003163 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 637910003164 catalytic residue [active] 637910003165 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 637910003166 catalytic residues [active] 637910003167 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637910003168 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637910003169 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 8.4e-46 637910003170 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 637910003171 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 1.6e-23 637910003172 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 637910003173 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 637910003174 Ligand Binding Site [chemical binding]; other site 637910003175 HMMPfam hit to PF00582, UspA, score 7e-20 637910003176 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 637910003177 Ligand Binding Site [chemical binding]; other site 637910003178 HMMPfam hit to PF00582, UspA, score 1.9e-16 637910003179 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 637910003180 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637910003181 NAD binding site [chemical binding]; other site 637910003182 catalytic Zn binding site [ion binding]; other site 637910003183 structural Zn binding site [ion binding]; other site 637910003184 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 6.6e-49 637910003185 PS00059 Zinc-containing alcohol dehydrogenases signature. 637910003186 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 7.2e-23 637910003187 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003188 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 637910003189 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 637910003190 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 637910003191 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 637910003192 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 637910003193 HMMPfam hit to PF00561, Alpha/beta hydrolase fold-1, score 1.6e-37 637910003194 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 637910003195 B1 nucleotide binding pocket [chemical binding]; other site 637910003196 B2 nucleotide binding pocket [chemical binding]; other site 637910003197 CAS motifs; other site 637910003198 active site 637910003199 PS00531 Ribonuclease T2 family histidine active site 2. 637910003200 PS00530 Ribonuclease T2 family histidine active site 1. 637910003201 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 637910003202 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 637910003203 transmembrane helices; other site 637910003204 HMMPfam hit to PF00939, Sodium/sulphate symporter, score 1.3e-285 637910003205 13 transmembrane helices predicted for ROD06271 by TMHMM2.0 at aa 7-24, 34-53, 58-75, 95-117, 138-157, 198-220, 233-255, 288-305, 312-329, 339-361, 374-396, 428-450 and 463-485 637910003206 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003207 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003208 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 637910003209 HMMPfam hit to PF01874, Triphosphoribosyl-dephospho-CoA protein, score 1.1e-129 637910003210 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 637910003211 HMMPfam hit to PF03802, Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase, score 3.1e-89 637910003212 PS00017 ATP/GTP-binding site motif A (P-loop). 637910003213 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 637910003214 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 637910003215 HMMPfam hit to PF04223, Citrate lyase, subunit alpha, score 0 637910003216 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910003217 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 637910003218 HMMPfam hit to PF03328, HpcH/HpaI aldolase, score 6.1e-118 637910003219 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 637910003220 HMMPfam hit to PF04953, Citrate lyase ACP CitD, score 3.4e-59 637910003221 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 637910003222 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 637910003223 putative active site [active] 637910003224 (T/H)XGH motif; other site 637910003225 HMMPfam hit to PF08218, Citrate lyase ligase, C-terminal, score 2.1e-126 637910003226 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.8e-05 637910003227 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 637910003228 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637910003229 putative active site [active] 637910003230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910003231 ATP binding site [chemical binding]; other site 637910003232 Mg2+ binding site [ion binding]; other site 637910003233 G-X-G motif; other site 637910003234 2 transmembrane helices predicted for ROD06341 by TMHMM2.0 at aa 20-42 and 180-202 637910003235 HMMPfam hit to PF00989, PAS fold, score 6.9e-06 637910003236 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.1e-25 637910003237 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 637910003238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910003239 active site 637910003240 phosphorylation site [posttranslational modification] 637910003241 intermolecular recognition site; other site 637910003242 dimerization interface [polypeptide binding]; other site 637910003243 Transcriptional regulator; Region: CitT; pfam12431 637910003244 HMMPfam hit to PF00072, Response regulator receiver, score 6.1e-24 637910003245 Predicted helix-turn-helix motif with score 1208.000, SD 3.30 at aa 178-199, sequence HTAETVSQALTISRTTARRYLE 637910003246 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 637910003247 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 637910003248 12 transmembrane helices predicted for ROD06361 by TMHMM2.0 at aa 4-22, 29-46, 80-99, 112-134, 138-157, 162-184, 199-218, 238-260, 270-289, 310-332, 336-358 and 436-458 637910003249 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 2.3e-202 637910003250 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 637910003251 1 transmembrane helix predicted for ROD06371 by TMHMM2.0 at aa 12-31 637910003252 HMMPfam hit to PF07017, Antimicrobial peptide resistance and lipid A acylation PagP, score 1.1e-115 637910003253 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 637910003254 DNA-binding site [nucleotide binding]; DNA binding site 637910003255 RNA-binding motif; other site 637910003256 HMMPfam hit to PF00313, Cold-shock protein, DNA-binding, score 2e-44 637910003257 PS00352 'Cold-shock' DNA-binding domain signature. 637910003258 chromosome condensation membrane protein; Provisional; Region: PRK14196 637910003259 HMMPfam hit to PF02537, Camphor resistance CrcB protein, score 1e-57 637910003260 4 transmembrane helices predicted for ROD06391 by TMHMM2.0 at aa 4-23, 32-54, 69-91 and 98-120 637910003261 Predicted amidohydrolase [General function prediction only]; Region: COG0388 637910003262 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 637910003263 putative active site [active] 637910003264 catalytic triad [active] 637910003265 putative dimer interface [polypeptide binding]; other site 637910003266 HMMPfam hit to PF00795, Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase, score 2.2e-25 637910003267 PS01227 Uncharacterized protein family UPF0012 signature. 637910003268 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 637910003269 HMMPfam hit to PF02416, Bacterial sec-independent translocation protein mttA/Hcf106, score 3e-09 637910003270 1 transmembrane helix predicted for ROD06411 by TMHMM2.0 at aa 4-21 637910003271 pseudogene, disrupted by ISCro1 insertion 637910003272 HMMPfam hit to PF01609, Transposase, IS4-like, score 2.7e-20 637910003273 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910003274 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910003275 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910003276 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910003277 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910003278 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910003279 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910003280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910003281 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910003282 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910003283 Transposase; Region: HTH_Tnp_1; pfam01527 637910003284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910003285 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910003286 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910003287 lipoyl synthase; Provisional; Region: PRK05481 637910003288 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910003289 FeS/SAM binding site; other site 637910003290 HMMPfam hit to PF04055, Radical SAM, score 8.8e-23 637910003291 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 637910003292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910003293 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 637910003294 substrate binding pocket [chemical binding]; other site 637910003295 dimerization interface [polypeptide binding]; other site 637910003296 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.3e-05 637910003297 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2.8e-15 637910003298 PS00044 Bacterial regulatory proteins, lysR family signature. 637910003299 Predicted helix-turn-helix motif with score 1490.000, SD 4.26 at aa 72-93, sequence KGIVNAAKILNLTPSAISQSIQ 637910003300 lipoate-protein ligase B; Provisional; Region: PRK14342 637910003301 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase, score 8.8e-19 637910003302 PS01313 Lipoate-protein ligase B signature. 637910003303 hypothetical protein; Provisional; Region: PRK04998 637910003304 HMMPfam hit to PF04359, Protein of unknown function DUF493, score 3.6e-54 637910003305 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 637910003306 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 637910003307 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 637910003308 HMMPfam hit to PF07943, Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal, score 1.1e-36 637910003309 HMMPfam hit to PF00768, Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, score 3.3e-153 637910003310 rare lipoprotein A; Provisional; Region: PRK10672 637910003311 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 637910003312 Sporulation related domain; Region: SPOR; pfam05036 637910003313 HMMPfam hit to PF05036, Sporulation/cell division region, bacteria, score 1.2e-19 637910003314 HMMPfam hit to PF03330, Rare lipoprotein A, score 8.5e-28 637910003315 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003316 cell wall shape-determining protein; Provisional; Region: PRK10794 637910003317 HMMPfam hit to PF01098, Cell cycle protein, score 6.1e-181 637910003318 9 transmembrane helices predicted for ROD06521 by TMHMM2.0 at aa 15-37, 50-67, 77-99, 136-155, 160-179, 181-203, 272-294, 306-328 and 338-360 637910003319 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 637910003320 penicillin-binding protein 2; Provisional; Region: PRK10795 637910003321 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637910003322 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 637910003323 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 1.8e-101 637910003324 HMMPfam hit to PF03717, Penicillin-binding protein, dimerisation domain, score 9.9e-69 637910003325 1 transmembrane helix predicted for ROD06531 by TMHMM2.0 at aa 21-43 637910003326 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 637910003327 HMMPfam hit to PF02590, Protein of unknown function DUF163, score 2e-111 637910003328 ribosome-associated protein; Provisional; Region: PRK11538 637910003329 HMMPfam hit to PF02410, Iojap-related protein, score 1.1e-53 637910003330 PS00017 ATP/GTP-binding site motif A (P-loop). 637910003331 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637910003332 catalytic core [active] 637910003333 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 4.8e-46 637910003334 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 637910003335 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 637910003336 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637910003337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910003338 homodimer interface [polypeptide binding]; other site 637910003339 catalytic residue [active] 637910003340 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 2.4e-37 637910003341 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 637910003342 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 637910003343 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 637910003344 active site 637910003345 (T/H)XGH motif; other site 637910003346 HMMPfam hit to PF01467, Cytidylyltransferase, score 1.7e-61 637910003347 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 637910003348 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 637910003349 HMMPfam hit to PF06144, DNA polymerase III, delta, score 2.9e-131 637910003350 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 637910003351 HMMPfam hit to PF04390, Rare lipoprotein B, score 3.2e-77 637910003352 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003353 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 637910003354 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 637910003355 HIGH motif; other site 637910003356 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 637910003357 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637910003358 active site 637910003359 KMSKS motif; other site 637910003360 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 637910003361 tRNA binding surface [nucleotide binding]; other site 637910003362 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 637910003363 HMMPfam hit to PF08264, Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding, score 1.8e-07 637910003364 HMMPfam hit to PF00133, Aminoacyl-tRNA synthetase, class Ia, score 1.3e-13 637910003365 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 637910003366 hypothetical protein; Provisional; Region: PRK11032 637910003367 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 637910003368 HMMPfam hit to PF07295, Protein of unknown function DUF1451, score 9.8e-103 637910003369 pseudogene, truncated by premature stop codon 637910003370 HMMPfam hit to PF01156, Inosine/uridine-preferring nucleoside hydrolase, score 2e-180 637910003371 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637910003372 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637910003373 Walker A/P-loop; other site 637910003374 ATP binding site [chemical binding]; other site 637910003375 Q-loop/lid; other site 637910003376 ABC transporter signature motif; other site 637910003377 Walker B; other site 637910003378 D-loop; other site 637910003379 H-loop/switch region; other site 637910003380 HMMPfam hit to PF00005, ABC transporter related, score 1.1e-67 637910003381 PS00211 ABC transporters family signature. 637910003382 PS00017 ATP/GTP-binding site motif A (P-loop). 637910003383 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637910003384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910003385 dimer interface [polypeptide binding]; other site 637910003386 conserved gate region; other site 637910003387 putative PBP binding loops; other site 637910003388 ABC-ATPase subunit interface; other site 637910003389 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 4.3e-32 637910003390 5 transmembrane helices predicted for ROD06661 by TMHMM2.0 at aa 15-37, 58-80, 95-112, 155-177 and 197-219 637910003391 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637910003392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910003393 dimer interface [polypeptide binding]; other site 637910003394 conserved gate region; other site 637910003395 putative PBP binding loops; other site 637910003396 ABC-ATPase subunit interface; other site 637910003397 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.2e-39 637910003398 5 transmembrane helices predicted for ROD06671 by TMHMM2.0 at aa 31-53, 66-88, 108-127, 179-196 and 211-233 637910003399 Predicted helix-turn-helix motif with score 1078.000, SD 2.86 at aa 139-160, sequence RGQKNAALAMGLTLPQAYRYVL 637910003400 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 637910003401 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637910003402 substrate binding pocket [chemical binding]; other site 637910003403 membrane-bound complex binding site; other site 637910003404 hinge residues; other site 637910003405 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 1.4e-55 637910003406 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 637910003407 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 637910003408 putative active site [active] 637910003409 catalytic triad [active] 637910003410 putative dimer interface [polypeptide binding]; other site 637910003411 6 transmembrane helices predicted for ROD06691 by TMHMM2.0 at aa 12-34, 57-79, 91-113, 166-188, 195-213 and 489-507 637910003412 HMMPfam hit to PF00795, Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase, score 1.9e-45 637910003413 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 637910003414 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637910003415 Transporter associated domain; Region: CorC_HlyC; smart01091 637910003416 HMMPfam hit to PF03471, Transporter-associated region, score 2.3e-30 637910003417 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 6.1e-29 637910003418 metal-binding heat shock protein; Provisional; Region: PRK00016 637910003419 HMMPfam hit to PF02130, Protein of unknown function UPF0054, score 8.8e-55 637910003420 PS01306 Uncharacterized protein family UPF0054 signature. 637910003421 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 637910003422 PhoH-like protein; Region: PhoH; pfam02562 637910003423 HMMPfam hit to PF02562, PhoH-like protein, score 2.3e-154 637910003424 PS00017 ATP/GTP-binding site motif A (P-loop). 637910003425 1 transmembrane helix predicted for ROD06731 by TMHMM2.0 at aa 10-32 637910003426 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 637910003427 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 637910003428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910003429 FeS/SAM binding site; other site 637910003430 TRAM domain; Region: TRAM; pfam01938 637910003431 HMMPfam hit to PF01938, Deoxyribonuclease/rho motif-related TRAM, score 2.7e-24 637910003432 HMMPfam hit to PF04055, Radical SAM, score 7.6e-33 637910003433 PS01278 Uncharacterized protein family UPF0004 signature. 637910003434 HMMPfam hit to PF00919, Protein of unknown function UPF0004, N-terminal, score 6.6e-51 637910003435 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 637910003436 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 637910003437 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 5.6e-07 637910003438 1 transmembrane helix predicted for ROD06751 by TMHMM2.0 at aa 7-29 637910003439 PS01304 ubiH/COQ6 monooxygenase family signature. 637910003440 asparagine synthetase B; Provisional; Region: asnB; PRK09431 637910003441 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 637910003442 active site 637910003443 dimer interface [polypeptide binding]; other site 637910003444 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 637910003445 Ligand Binding Site [chemical binding]; other site 637910003446 Molecular Tunnel; other site 637910003447 HMMPfam hit to PF00733, Asparagine synthase, score 2e-111 637910003448 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 6.3e-27 637910003449 PS00443 Glutamine amidotransferases class-II active site. 637910003450 UMP phosphatase; Provisional; Region: PRK10444 637910003451 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910003452 active site 637910003453 motif I; other site 637910003454 motif II; other site 637910003455 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910003456 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.5e-17 637910003457 MarR family; Region: MarR; pfam01047 637910003458 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637910003459 ROK family; Region: ROK; pfam00480 637910003460 HMMPfam hit to PF00480, ROK, score 4.4e-90 637910003461 PS01125 ROK family signature. 637910003462 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 2.5e-07 637910003463 Predicted helix-turn-helix motif with score 1021.000, SD 2.66 at aa 33-54, sequence ISRIQIAEQSQLAPASVTKITR 637910003464 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 637910003465 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 637910003466 active site 637910003467 dimer interface [polypeptide binding]; other site 637910003468 HMMPfam hit to PF01979, Amidohydrolase 1, score 5.4e-54 637910003469 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 637910003470 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 637910003471 active site 637910003472 trimer interface [polypeptide binding]; other site 637910003473 allosteric site; other site 637910003474 active site lid [active] 637910003475 hexamer (dimer of trimers) interface [polypeptide binding]; other site 637910003476 HMMPfam hit to PF01182, Glucosamine/galactosamine-6-phosphate isomerase, score 4.7e-194 637910003477 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003478 PS01161 Glucosamine/galactosamine-6-phosphate isomerases signature. 637910003479 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 637910003480 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 637910003481 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637910003482 active site turn [active] 637910003483 phosphorylation site [posttranslational modification] 637910003484 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 637910003485 HPr interaction site; other site 637910003486 glycerol kinase (GK) interaction site [polypeptide binding]; other site 637910003487 active site 637910003488 phosphorylation site [posttranslational modification] 637910003489 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 3.5e-100 637910003490 11 transmembrane helices predicted for ROD06811 by TMHMM2.0 at aa 13-30, 40-62, 69-91, 96-118, 131-153, 163-185, 192-214, 229-251, 258-280, 295-317 and 337-359 637910003491 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 3.8e-15 637910003492 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 637910003493 HMMPfam hit to PF00358, Phosphotransferase system, sugar-specific permease EIIA 1 domain, score 3.2e-85 637910003494 PS00371 PTS EIIA domains phosphorylation site signature 1. 637910003495 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910003496 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910003497 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910003498 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910003499 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910003500 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910003501 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910003502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910003503 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910003504 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910003505 Transposase; Region: HTH_Tnp_1; pfam01527 637910003506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910003507 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910003508 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910003509 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 637910003510 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 637910003511 active site 637910003512 HIGH motif; other site 637910003513 nucleotide binding site [chemical binding]; other site 637910003514 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 637910003515 KMSKS motif; other site 637910003516 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 637910003517 HMMPfam hit to PF00749, Glutamyl/glutaminyl-tRNA synthetase, class Ic, score 3.9e-188 637910003518 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 637910003519 HMMPfam hit to PF03950, Glutamyl/glutaminyl-tRNA synthetase, class Ic, score 8.5e-109 637910003520 outer membrane porin, OprD family; Region: OprD; pfam03573 637910003521 HMMPfam hit to PF03573, Outer membrane porin, bacterial, score 8.5e-07 637910003522 1 transmembrane helix predicted for ROD06861 by TMHMM2.0 at aa 9-31 637910003523 citrate-proton symporter; Provisional; Region: PRK15075 637910003524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910003525 putative substrate translocation pore; other site 637910003526 12 transmembrane helices predicted for ROD06871 by TMHMM2.0 at aa 13-35, 50-72, 85-107, 117-139, 160-179, 189-208, 236-258, 273-295, 302-324, 334-353, 366-388 and 398-420 637910003527 HMMPfam hit to PF00083, General substrate transporter score 4e-72 637910003528 PS00216 Sugar transport proteins signature 1. 637910003529 PS00217 Sugar transport proteins signature 2. 637910003530 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003531 PS00216 Sugar transport proteins signature 1. 637910003532 tricarballylate utilization protein B; Provisional; Region: PRK15033 637910003533 6 transmembrane helices predicted for ROD06881 by TMHMM2.0 at aa 112-134, 154-176, 230-252, 262-284, 305-322 and 326-348 637910003534 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0032 637910003535 tricarballylate dehydrogenase; Validated; Region: PRK08274 637910003536 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637910003537 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 6.8e-09 637910003538 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910003539 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910003540 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 637910003541 putative dimerization interface [polypeptide binding]; other site 637910003542 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.3e-38 637910003543 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 5.1e-15 637910003544 ferric uptake regulator; Provisional; Region: fur; PRK09462 637910003545 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 637910003546 metal binding site 2 [ion binding]; metal-binding site 637910003547 putative DNA binding helix; other site 637910003548 metal binding site 1 [ion binding]; metal-binding site 637910003549 dimer interface [polypeptide binding]; other site 637910003550 structural Zn2+ binding site [ion binding]; other site 637910003551 HMMPfam hit to PF01475, Ferric-uptake regulator, score 3.2e-74 637910003552 flavodoxin FldA; Validated; Region: PRK09267 637910003553 HMMPfam hit to PF00258, Flavodoxin/nitric oxide synthase, score 8.9e-55 637910003554 PS00201 Flavodoxin signature. 637910003555 LexA regulated protein; Provisional; Region: PRK11675 637910003556 HMMPfam hit to PF01402, CopG-like DNA-binding, score 2.1e-08 637910003557 acyl-CoA esterase; Provisional; Region: PRK10673 637910003558 PGAP1-like protein; Region: PGAP1; pfam07819 637910003559 HMMPfam hit to PF00561, Alpha/beta hydrolase fold-1, score 1.3e-21 637910003560 replication initiation regulator SeqA; Provisional; Region: PRK11187 637910003561 HMMPfam hit to PF03925, SeqA protein, score 7.5e-138 637910003562 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 637910003563 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 637910003564 active site 637910003565 substrate binding site [chemical binding]; other site 637910003566 metal binding site [ion binding]; metal-binding site 637910003567 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I, score 5.6e-43 637910003568 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 637910003569 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II, score 3.9e-19 637910003570 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III, score 3.5e-29 637910003571 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase C-terminal, score 9e-15 637910003572 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910003573 1 transmembrane helix predicted for ROD06971 by TMHMM2.0 at aa 309-331 637910003574 HMMPfam hit to PF01609, Transposase, IS4-like, score 5.4e-13 637910003575 putrescine transporter; Provisional; Region: potE; PRK10655 637910003576 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 637910003577 12 transmembrane helices predicted for ROD06981 by TMHMM2.0 at aa 9-31, 37-59, 89-111, 121-143, 150-172, 187-206, 227-249, 269-291, 323-342, 352-374, 387-405 and 410-429 637910003578 HMMPfam hit to PF00324, Amino acid permease-associated region, score 1.8e-08 637910003579 PS00017 ATP/GTP-binding site motif A (P-loop). 637910003580 ornithine decarboxylase; Provisional; Region: PRK13578 637910003581 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 637910003582 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 637910003583 homodimer interface [polypeptide binding]; other site 637910003584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910003585 catalytic residue [active] 637910003586 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 637910003587 HMMPfam hit to PF03711, Orn/Lys/Arg decarboxylase, C-terminal, score 1.8e-85 637910003588 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase, major region, score 0 637910003589 PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. 637910003590 HMMPfam hit to PF03709, Orn/Lys/Arg decarboxylase, N-terminal, score 2.5e-46 637910003591 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 637910003592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910003593 active site 637910003594 phosphorylation site [posttranslational modification] 637910003595 intermolecular recognition site; other site 637910003596 dimerization interface [polypeptide binding]; other site 637910003597 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637910003598 DNA binding site [nucleotide binding] 637910003599 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 7.9e-18 637910003600 HMMPfam hit to PF00072, Response regulator receiver, score 1.1e-47 637910003601 sensor protein KdpD; Provisional; Region: PRK10490 637910003602 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 637910003603 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 637910003604 Ligand Binding Site [chemical binding]; other site 637910003605 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 637910003606 GAF domain; Region: GAF_3; pfam13492 637910003607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637910003608 dimer interface [polypeptide binding]; other site 637910003609 phosphorylation site [posttranslational modification] 637910003610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910003611 ATP binding site [chemical binding]; other site 637910003612 Mg2+ binding site [ion binding]; other site 637910003613 G-X-G motif; other site 637910003614 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.6e-37 637910003615 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 5.5e-15 637910003616 3 transmembrane helices predicted for ROD07011 by TMHMM2.0 at aa 402-424, 444-466 and 479-501 637910003617 HMMPfam hit to PF00582, UspA, score 1.1e-10 637910003618 HMMPfam hit to PF02702, Osmosensitive K+ channel His kinase sensor, N-terminal, score 9.5e-155 637910003619 PS00017 ATP/GTP-binding site motif A (P-loop). 637910003620 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 637910003621 HMMPfam hit to PF02669, K+ transporting ATPase, KdpC subunit, score 3.4e-112 637910003622 Predicted helix-turn-helix motif with score 1158.000, SD 3.13 at aa 139-160, sequence WQIPRVARARNLSVETVTQLVA 637910003623 1 transmembrane helix predicted for ROD07021 by TMHMM2.0 at aa 7-29 637910003624 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 637910003625 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637910003626 7 transmembrane helices predicted for ROD07031 by TMHMM2.0 at aa 36-58, 63-85, 220-242, 252-274, 578-600, 615-634 and 654-676 637910003627 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 3.9e-35 637910003628 PS00154 E1-E2 ATPases phosphorylation site. 637910003629 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 3e-63 637910003630 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 637910003631 HMMPfam hit to PF03814, K+ transporting ATPase, A subunit, score 0 637910003632 12 transmembrane helices predicted for ROD07041 by TMHMM2.0 at aa 5-27, 62-81, 130-152, 173-195, 248-270, 282-304, 327-349, 354-376, 380-399, 419-441, 483-505 and 526-548 637910003633 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003634 1 transmembrane helix predicted for ROD07042 by TMHMM2.0 at aa 4-26 637910003635 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 637910003636 1 transmembrane helix predicted for ROD07051 by TMHMM2.0 at aa 11-33 637910003637 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 637910003638 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910003639 HMMPfam hit to PF01609, Transposase, IS4-like, score 3.6e-20 637910003640 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 637910003641 DNA photolyase; Region: DNA_photolyase; pfam00875 637910003642 HMMPfam hit to PF00875, DNA photolyase, N-terminal, score 1.7e-73 637910003643 HMMPfam hit to PF03441, DNA photolyase, FAD-binding, score 7.1e-151 637910003644 PS00394 DNA photolyases class 1 signature 1. 637910003645 PS00691 DNA photolyases class 1 signature 2. 637910003646 putative transposase; Provisional; Region: PRK09857 637910003647 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 637910003648 HMMPfam hit to PF04754, Transposase (), YhgA-like, score 1.2e-211 637910003649 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 637910003650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910003651 putative substrate translocation pore; other site 637910003652 POT family; Region: PTR2; pfam00854 637910003653 14 transmembrane helices predicted for ROD07091 by TMHMM2.0 at aa 13-35, 45-67, 72-94, 98-117, 138-160, 165-187, 208-230, 235-254, 267-284, 310-332, 344-366, 376-398, 410-432 and 462-479 637910003654 HMMPfam hit to PF00854, TGF-beta receptor, type I/II extracellular region, score 9e-98 637910003655 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 637910003656 PS01022 PTR2 family proton/oligopeptide symporters signature 1. 637910003657 Uncharacterized conserved protein [Function unknown]; Region: COG0327 637910003658 metal-binding protein; Provisional; Region: PRK10799 637910003659 HMMPfam hit to PF01784, NGG1p interacting factor 3, NIF3, score 1.4e-113 637910003660 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 637910003661 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 637910003662 HMMPfam hit to PF02682, Allophanate hydrolase subunit 1, score 5.7e-134 637910003663 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 637910003664 HMMPfam hit to PF02626, Allophanate hydrolase subunit 2, score 1.5e-166 637910003665 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 637910003666 putative active site [active] 637910003667 HMMPfam hit to PF03746, LamB/YcsF, score 5.5e-148 637910003668 Protein of unknown function (DUF969); Region: DUF969; pfam06149 637910003669 HMMPfam hit to PF06149, Protein of unknown function DUF969, score 7.8e-151 637910003670 5 transmembrane helices predicted for ROD07141 by TMHMM2.0 at aa 5-22, 27-49, 64-81, 163-185 and 198-220 637910003671 Predicted membrane protein [Function unknown]; Region: COG3817 637910003672 Protein of unknown function (DUF979); Region: DUF979; pfam06166 637910003673 10 transmembrane helices predicted for ROD07151 by TMHMM2.0 at aa 5-24, 37-54, 64-86, 107-129, 139-161, 182-204, 214-236, 243-260, 270-292 and 313-330 637910003674 HMMPfam hit to PF06166, Protein of unknown function DUF979, score 1.4e-149 637910003675 pseudogene, C-terminus missing, truncated by downstream deletion event 637910003676 HMMPfam hit to PF01470, Peptidase C15, pyroglutamyl peptidase I, score 2.2e-15 637910003677 pseudogene, N-terminus missing, truncated by upstream deletion event 637910003678 HMMPfam hit to PF06831, Formamidopyrimidine-DNA glycolase, H2TH DNA binding, score 3.6e-18 637910003679 HMMPfam hit to PF06827, Formamidopyrimidine-DNA glycolase, C-terminal, score 0.00041 637910003680 Putative ammonia monooxygenase; Region: AmoA; pfam05145 637910003681 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 637910003682 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 637910003683 HMMPfam hit to PF05145, ammonia monooxygenase, score 2.6e-133 637910003684 9 transmembrane helices predicted for ROD07171 by TMHMM2.0 at aa 20-42, 54-76, 81-103, 144-163, 178-200, 205-227, 259-281, 288-310 and 314-336 637910003685 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003686 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 637910003687 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 637910003688 dimer interface [polypeptide binding]; other site 637910003689 active site 637910003690 citrylCoA binding site [chemical binding]; other site 637910003691 NADH binding [chemical binding]; other site 637910003692 cationic pore residues; other site 637910003693 oxalacetate/citrate binding site [chemical binding]; other site 637910003694 coenzyme A binding site [chemical binding]; other site 637910003695 catalytic triad [active] 637910003696 HMMPfam hit to PF00285, Citrate synthase, score 1e-234 637910003697 PS00480 Citrate synthase signature. 637910003698 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 637910003699 Iron-sulfur protein interface; other site 637910003700 proximal quinone binding site [chemical binding]; other site 637910003701 SdhD (CybS) interface [polypeptide binding]; other site 637910003702 proximal heme binding site [chemical binding]; other site 637910003703 HMMPfam hit to PF01127, Succinate dehydrogenase, cytochrome b subunit, score 2.2e-44 637910003704 PS01000 Succinate dehydrogenase cytochrome b subunit signature 1. 637910003705 3 transmembrane helices predicted for ROD07191 by TMHMM2.0 at aa 32-54, 69-91 and 117-133 637910003706 PS01001 Succinate dehydrogenase cytochrome b subunit signature 2. 637910003707 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 637910003708 SdhC subunit interface [polypeptide binding]; other site 637910003709 proximal heme binding site [chemical binding]; other site 637910003710 cardiolipin binding site; other site 637910003711 Iron-sulfur protein interface; other site 637910003712 proximal quinone binding site [chemical binding]; other site 637910003713 3 transmembrane helices predicted for ROD07201 by TMHMM2.0 at aa 16-38, 48-70 and 91-113 637910003714 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 637910003715 L-aspartate oxidase; Provisional; Region: PRK06175 637910003716 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 637910003717 HMMPfam hit to PF00890, Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal, score 1.2e-171 637910003718 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 637910003719 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydrogenase flavoprotein, C-terminal, score 6.4e-69 637910003720 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 637910003721 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 637910003722 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910003723 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 637910003724 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 637910003725 TPP-binding site [chemical binding]; other site 637910003726 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 637910003727 dimer interface [polypeptide binding]; other site 637910003728 PYR/PP interface [polypeptide binding]; other site 637910003729 TPP binding site [chemical binding]; other site 637910003730 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 637910003731 HMMPfam hit to PF00676, Dehydrogenase, E1 component, score 1.5e-29 637910003732 HMMPfam hit to PF02779, Transketolase, central region, score 1.8e-76 637910003733 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 637910003734 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 637910003735 E3 interaction surface; other site 637910003736 lipoyl attachment site [posttranslational modification]; other site 637910003737 e3 binding domain; Region: E3_binding; pfam02817 637910003738 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 637910003739 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 2.5e-21 637910003740 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 637910003741 HMMPfam hit to PF02817, E3 binding, score 4.7e-17 637910003742 HMMPfam hit to PF00198, Catalytic domain of components of various dehydrogenase complexes, score 1.7e-142 637910003743 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 637910003744 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 637910003745 CoA-ligase; Region: Ligase_CoA; pfam00549 637910003746 HMMPfam hit to PF08442, ATP-grasp fold, succinyl-CoA synthetase-type, score 3.1e-146 637910003747 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003748 HMMPfam hit to PF00549, ATP-citrate lyase/succinyl-CoA ligase, score 2.4e-81 637910003749 PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. 637910003750 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 637910003751 CoA binding domain; Region: CoA_binding; smart00881 637910003752 CoA-ligase; Region: Ligase_CoA; pfam00549 637910003753 HMMPfam hit to PF02629, CoA-binding, score 2.1e-49 637910003754 HMMPfam hit to PF00549, ATP-citrate lyase/succinyl-CoA ligase, score 1.9e-64 637910003755 PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. 637910003756 PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. 637910003757 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 637910003758 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 637910003759 HMMPfam hit to PF01654, Cytochrome bd ubiquinol oxidase, subunit I, score 0 637910003760 9 transmembrane helices predicted for ROD07271 by TMHMM2.0 at aa 20-42, 54-76, 96-118, 130-152, 185-207, 219-238, 387-409, 421-443 and 472-494 637910003761 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 637910003762 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 637910003763 HMMPfam hit to PF02322, Cytochrome bd ubiquinol oxidase, subunit II, score 1.6e-224 637910003764 8 transmembrane helices predicted for ROD07281 by TMHMM2.0 at aa 7-24, 77-99, 122-144, 159-181, 202-224, 262-281, 293-315 and 338-360 637910003765 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003766 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 637910003767 HMMPfam hit to PF08173, Membrane bound YbgT-like, score 4.9e-14 637910003768 1 transmembrane helix predicted for ROD07282 by TMHMM2.0 at aa 2-24 637910003769 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003770 hypothetical protein; Provisional; Region: PRK10588 637910003771 3 transmembrane helices predicted for ROD07291 by TMHMM2.0 at aa 19-36, 46-68 and 77-96 637910003772 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003773 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 637910003774 active site 637910003775 PS01328 4-hydroxybenzoyl-CoA thioesterase family active site. 637910003776 HMMPfam hit to PF03061, Thioesterase superfamily, score 1.2e-19 637910003777 colicin uptake protein TolQ; Provisional; Region: PRK10801 637910003778 3 transmembrane helices predicted for ROD07311 by TMHMM2.0 at aa 15-37, 133-155 and 170-192 637910003779 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel, score 4e-63 637910003780 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 637910003781 colicin uptake protein TolR; Provisional; Region: PRK11024 637910003782 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 2.1e-15 637910003783 1 transmembrane helix predicted for ROD07321 by TMHMM2.0 at aa 17-39 637910003784 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 637910003785 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 637910003786 TolA C-terminal; Region: TolA; pfam06519 637910003787 HMMPfam hit to PF06519, Tol-Pal system, TolA, score 2.5e-188 637910003788 1 transmembrane helix predicted for ROD07331 by TMHMM2.0 at aa 13-35 637910003789 PS00017 ATP/GTP-binding site motif A (P-loop). 637910003790 translocation protein TolB; Provisional; Region: tolB; PRK03629 637910003791 TolB amino-terminal domain; Region: TolB_N; pfam04052 637910003792 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 637910003793 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 637910003794 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 637910003795 HMMPfam hit to PF04052, TolB, N-terminal, score 1.1e-86 637910003796 HMMPfam hit to PF07676, WD40-like Beta Propeller, score 0.48 637910003797 HMMPfam hit to PF07676, WD40-like Beta Propeller, score 1.6e-06 637910003798 HMMPfam hit to PF07676, WD40-like Beta Propeller, score 2.2e-06 637910003799 HMMPfam hit to PF07676, WD40-like Beta Propeller, score 4.1 637910003800 HMMPfam hit to PF07676, WD40-like Beta Propeller, score 0.057 637910003801 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 637910003802 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637910003803 ligand binding site [chemical binding]; other site 637910003804 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003805 HMMPfam hit to PF00691, Outer membrane protein, OmpA/MotB, C-terminal, score 6.8e-50 637910003806 PS01068 OmpA-like domain. 637910003807 tol-pal system protein YbgF; Provisional; Region: PRK10803 637910003808 Tetratricopeptide repeat; Region: TPR_6; pfam13174 637910003809 Tetratricopeptide repeat; Region: TPR_6; pfam13174 637910003810 HMMPfam hit to PF07719, Tetratricopeptide TPR2, score 0.003 637910003811 HMMPfam hit to PF07719, Tetratricopeptide TPR2, score 0.0039 637910003812 quinolinate synthetase; Provisional; Region: PRK09375 637910003813 HMMPfam hit to PF02445, Quinolinate synthetase A, score 1.1e-187 637910003814 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 637910003815 HMMPfam hit to PF04973, Nicotinamide mononucleotide transporter PnuC, score 7.2e-102 637910003816 6 transmembrane helices predicted for ROD07391 by TMHMM2.0 at aa 20-42, 49-68, 72-89, 110-132, 158-177 and 184-206 637910003817 zinc transporter ZitB; Provisional; Region: PRK03557 637910003818 HMMPfam hit to PF01545, Cation efflux protein, score 1e-114 637910003819 PS00511 Corticotropin-releasing factor family signature. 637910003820 5 transmembrane helices predicted for ROD07401 by TMHMM2.0 at aa 21-43, 53-71, 84-106, 121-143 and 164-183 637910003821 YbgS-like protein; Region: YbgS; pfam13985 637910003822 PS00141 Eukaryotic and viral aspartyl proteases active site. 637910003823 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 637910003824 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 637910003825 HMMPfam hit to PF00793, DAHP synthetase I/KDSA, score 6.3e-183 637910003826 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 637910003827 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637910003828 N-terminal plug; other site 637910003829 ligand-binding site [chemical binding]; other site 637910003830 HMMPfam hit to PF07715, TonB-dependent receptor, plug, score 3.6e-14 637910003831 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 1.9e-23 637910003832 PS01156 TonB-dependent receptor proteins signature 2. 637910003833 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 637910003834 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 637910003835 putative ligand binding residues [chemical binding]; other site 637910003836 HMMPfam hit to PF01497, Periplasmic binding protein, score 1.2e-08 637910003837 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 637910003838 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 637910003839 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637910003840 ABC-ATPase subunit interface; other site 637910003841 dimer interface [polypeptide binding]; other site 637910003842 putative PBP binding regions; other site 637910003843 9 transmembrane helices predicted for ROD07451 by TMHMM2.0 at aa 31-53, 82-99, 112-134, 144-162, 175-197, 217-236, 269-291, 306-325 and 332-354 637910003844 HMMPfam hit to PF01032, Bacterial transport system permease, score 2.7e-80 637910003845 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 637910003846 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637910003847 Walker A/P-loop; other site 637910003848 ATP binding site [chemical binding]; other site 637910003849 Q-loop/lid; other site 637910003850 ABC transporter signature motif; other site 637910003851 Walker B; other site 637910003852 D-loop; other site 637910003853 H-loop/switch region; other site 637910003854 HMMPfam hit to PF00005, ABC transporter related, score 6.9e-51 637910003855 PS00017 ATP/GTP-binding site motif A (P-loop). 637910003856 PS00211 ABC transporters family signature. 637910003857 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637910003858 catalytic core [active] 637910003859 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637910003860 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 2e-44 637910003861 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 637910003862 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 637910003863 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 637910003864 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 3.5e-57 637910003865 10 transmembrane helices predicted for ROD07481 by TMHMM2.0 at aa 31-53, 85-107, 114-133, 143-165, 185-207, 217-239, 246-268, 300-322, 359-381 and 405-427 637910003866 PS00449 ATP synthase a subunit signature. 637910003867 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 637910003868 Cupin domain; Region: Cupin_2; pfam07883 637910003869 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910003870 HMMPfam hit to PF07883, Cupin 2, conserved barrel, score 0.0015 637910003871 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 9e-09 637910003872 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 637910003873 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 637910003874 NAD binding site [chemical binding]; other site 637910003875 sugar binding site [chemical binding]; other site 637910003876 divalent metal binding site [ion binding]; other site 637910003877 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637910003878 dimer interface [polypeptide binding]; other site 637910003879 HMMPfam hit to PF02056, Glycoside hydrolase, family 4, score 5.5e-192 637910003880 PS01324 Glycosyl hydrolases family 4 signature. 637910003881 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 637910003882 putative active site [active] 637910003883 YdjC motif; other site 637910003884 Mg binding site [ion binding]; other site 637910003885 putative homodimer interface [polypeptide binding]; other site 637910003886 HMMPfam hit to PF04794, YdjC-like protein, score 8.8e-93 637910003887 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 637910003888 active site 637910003889 catalytic residues [active] 637910003890 HMMPfam hit to PF01263, Aldose 1-epimerase, score 2.6e-124 637910003891 PS00545 Aldose 1-epimerase active site. 637910003892 galactokinase; Provisional; Region: PRK05101 637910003893 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 637910003894 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 637910003895 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 637910003896 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 2e-14 637910003897 HMMPfam hit to PF00288, GHMP kinase, score 1.9e-19 637910003898 PS00627 GHMP kinases ATP-binding domain. 637910003899 PS00106 Galactokinase signature. 637910003900 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 637910003901 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 637910003902 dimer interface [polypeptide binding]; other site 637910003903 active site 637910003904 HMMPfam hit to PF02744, Galactose-1-phosphate uridyl transferase, C-terminal, score 3.3e-103 637910003905 HMMPfam hit to PF01087, Galactose-1-phosphate uridyl transferase, N-terminal, score 2.8e-105 637910003906 PS00117 Galactose-1-phosphate uridyl transferase family 1 active site signature. 637910003907 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 637910003908 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 637910003909 NAD binding site [chemical binding]; other site 637910003910 homodimer interface [polypeptide binding]; other site 637910003911 active site 637910003912 substrate binding site [chemical binding]; other site 637910003913 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 1.3e-85 637910003914 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 637910003915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910003916 Walker A/P-loop; other site 637910003917 ATP binding site [chemical binding]; other site 637910003918 Q-loop/lid; other site 637910003919 ABC transporter signature motif; other site 637910003920 Walker B; other site 637910003921 D-loop; other site 637910003922 H-loop/switch region; other site 637910003923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910003924 Walker A/P-loop; other site 637910003925 ATP binding site [chemical binding]; other site 637910003926 Q-loop/lid; other site 637910003927 ABC transporter signature motif; other site 637910003928 Walker B; other site 637910003929 D-loop; other site 637910003930 H-loop/switch region; other site 637910003931 HMMPfam hit to PF00005, ABC transporter related, score 5e-48 637910003932 PS00017 ATP/GTP-binding site motif A (P-loop). 637910003933 PS00041 Bacterial regulatory proteins, araC family signature. 637910003934 HMMPfam hit to PF00005, ABC transporter related, score 1.2e-19 637910003935 PS00017 ATP/GTP-binding site motif A (P-loop). 637910003936 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 637910003937 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 637910003938 molybdenum-pterin binding domain; Region: Mop; TIGR00638 637910003939 TOBE domain; Region: TOBE; pfam03459 637910003940 HMMPfam hit to PF03459, Transport-associated OB, type 1, score 5.6e-13 637910003941 HMMPfam hit to PF03459, Transport-associated OB, type 1, score 1.3e-15 637910003942 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.9e-16 637910003943 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 637910003944 1 transmembrane helix predicted for ROD07581 by TMHMM2.0 at aa 42-64 637910003945 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 637910003946 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637910003947 substrate binding pocket [chemical binding]; other site 637910003948 membrane-bound complex binding site; other site 637910003949 hinge residues; other site 637910003950 PS00430 TonB-dependent receptor proteins signature 1. 637910003951 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 2.7e-09 637910003952 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 637910003953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910003954 dimer interface [polypeptide binding]; other site 637910003955 conserved gate region; other site 637910003956 putative PBP binding loops; other site 637910003957 ABC-ATPase subunit interface; other site 637910003958 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.8e-24 637910003959 5 transmembrane helices predicted for ROD07601 by TMHMM2.0 at aa 15-37, 49-71, 91-113, 134-156 and 197-219 637910003960 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910003961 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 637910003962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910003963 Walker A/P-loop; other site 637910003964 ATP binding site [chemical binding]; other site 637910003965 Q-loop/lid; other site 637910003966 ABC transporter signature motif; other site 637910003967 Walker B; other site 637910003968 D-loop; other site 637910003969 H-loop/switch region; other site 637910003970 molybdenum-pterin binding domain; Region: Mop; TIGR00638 637910003971 HMMPfam hit to PF00005, ABC transporter related, score 2.6e-68 637910003972 PS00017 ATP/GTP-binding site motif A (P-loop). 637910003973 PS00211 ABC transporters family signature. 637910003974 HMMPfam hit to PF03459, Transport-associated OB, type 1, score 4e-13 637910003975 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 637910003976 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910003977 active site 637910003978 motif I; other site 637910003979 motif II; other site 637910003980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910003981 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 4.9e-86 637910003982 PS01229 Hypothetical cof family signature 2. 637910003983 PS01228 Hypothetical cof family signature 1. 637910003984 6-phosphogluconolactonase; Provisional; Region: PRK11028 637910003985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910003986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910003987 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 637910003988 putative dimerization interface [polypeptide binding]; other site 637910003989 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.4e-52 637910003990 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 7.6e-21 637910003991 PS00044 Bacterial regulatory proteins, lysR family signature. 637910003992 Predicted helix-turn-helix motif with score 1419.000, SD 4.02 at aa 18-39, sequence ESFNNAAKLLNITQPALTRRIK 637910003993 PrpF protein; Region: PrpF; pfam04303 637910003994 HMMPfam hit to PF04303, Protein of unknown function DUF453, score 9.8e-205 637910003995 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910003996 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 637910003997 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 637910003998 transmembrane helices; other site 637910003999 HMMPfam hit to PF00939, Sodium/sulphate symporter, score 9.5e-259 637910004000 15 transmembrane helices predicted for ROD07661 by TMHMM2.0 at aa 5-27, 31-48, 55-73, 83-105, 112-134, 149-166, 183-205, 220-242, 274-293, 297-314, 327-349, 364-381, 394-416, 421-439 and 446-468 637910004001 putative hydratase; Provisional; Region: PRK11413 637910004002 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 637910004003 substrate binding site [chemical binding]; other site 637910004004 ligand binding site [chemical binding]; other site 637910004005 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 637910004006 substrate binding site [chemical binding]; other site 637910004007 HMMPfam hit to PF00330, Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, score 2.1e-17 637910004008 HMMPfam hit to PF00694, Aconitase A/isopropylmalate dehydratase small subunit, swivel, score 0.037 637910004009 acyl-CoA thioesterase; Provisional; Region: PRK10531 637910004010 putative pectinesterase; Region: PLN02432; cl01911 637910004011 HMMPfam hit to PF01095, Pectinesterase, catalytic, score 2.5e-07 637910004012 PS00503 Pectinesterase signature 2. 637910004013 PS00800 Pectinesterase signature 1. 637910004014 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910004015 imidazolonepropionase; Validated; Region: PRK09356 637910004016 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 637910004017 active site 637910004018 HMMPfam hit to PF01979, Amidohydrolase 1, score 9.3e-05 637910004019 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 637910004020 putative active site [active] 637910004021 putative metal binding site [ion binding]; other site 637910004022 HMMPfam hit to PF00491, Ureohydrolase, score 1.1e-08 637910004023 PS00147 Arginase family signature 1. 637910004024 PS01053 Arginase family signature 3. 637910004025 histidine utilization repressor; Provisional; Region: PRK14999 637910004026 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910004027 DNA-binding site [nucleotide binding]; DNA binding site 637910004028 UTRA domain; Region: UTRA; pfam07702 637910004029 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 5.2e-29 637910004030 PS00043 Bacterial regulatory proteins, gntR family signature. 637910004031 Predicted helix-turn-helix motif with score 1163.000, SD 3.15 at aa 37-58, sequence PSEAELVAQYGFSRMTINRALR 637910004032 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 6.6e-46 637910004033 urocanate hydratase; Provisional; Region: PRK05414 637910004034 HMMPfam hit to PF01175, Urocanase, score 0 637910004035 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910004036 PS01233 Urocanase active site. 637910004037 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 637910004038 active sites [active] 637910004039 tetramer interface [polypeptide binding]; other site 637910004040 HMMPfam hit to PF00221, Phenylalanine/histidine ammonia-lyase, score 2.6e-255 637910004041 PS00488 Phenylalanine and histidine ammonia-lyases signature. 637910004042 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 637910004043 substrate binding site [chemical binding]; other site 637910004044 HMMPfam hit to PF01161, PEBP, score 8.9e-07 637910004045 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 637910004046 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 637910004047 inhibitor-cofactor binding pocket; inhibition site 637910004048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910004049 catalytic residue [active] 637910004050 HMMPfam hit to PF00202, Aminotransferase class-III, score 2.5e-147 637910004051 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 637910004052 biotin synthase; Provisional; Region: PRK15108 637910004053 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910004054 FeS/SAM binding site; other site 637910004055 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 637910004056 HMMPfam hit to PF04055, Radical SAM, score 2.7e-24 637910004057 HMMPfam hit to PF06968, Biotin and thiamin synthesis associated, score 4.8e-52 637910004058 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910004059 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 637910004060 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 637910004061 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637910004062 catalytic residue [active] 637910004063 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 2.3e-81 637910004064 Predicted helix-turn-helix motif with score 1084.000, SD 2.88 at aa 131-152, sequence LSHASLLEAANLSPAQLRRFTH 637910004065 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 637910004066 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 637910004067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910004068 S-adenosylmethionine binding site [chemical binding]; other site 637910004069 HMMPfam hit to PF08241, Methyltransferase type 11, score 2.3e-34 637910004070 AAA domain; Region: AAA_26; pfam13500 637910004071 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 637910004072 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 637910004073 ADP binding site [chemical binding]; other site 637910004074 HMMPfam hit to PF01656, Cobyrinic acid a,c-diamide synthase, score 2.2e-24 637910004075 excinuclease ABC subunit B; Provisional; Region: PRK05298 637910004076 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637910004077 ATP binding site [chemical binding]; other site 637910004078 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637910004079 nucleotide binding region [chemical binding]; other site 637910004080 ATP-binding site [chemical binding]; other site 637910004081 Ultra-violet resistance protein B; Region: UvrB; pfam12344 637910004082 UvrB/uvrC motif; Region: UVR; pfam02151 637910004083 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/type III, Res subunit, score 1.4e-09 637910004084 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004085 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 7.5e-21 637910004086 HMMPfam hit to PF02151, UvrB/UvrC protein, score 3.1e-14 637910004087 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 637910004088 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 637910004089 putative substrate binding pocket [chemical binding]; other site 637910004090 dimer interface [polypeptide binding]; other site 637910004091 phosphate binding site [ion binding]; other site 637910004092 HMMPfam hit to PF01933, Protein of unknown function UPF0052 and CofD, score 8.5e-129 637910004093 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 637910004094 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910004095 FeS/SAM binding site; other site 637910004096 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 637910004097 HMMPfam hit to PF04055, Radical SAM, score 1.1e-38 637910004098 PS01305 moaA / nifB / pqqE family signature. 637910004099 HMMPfam hit to PF06463, Molybdenum cofactor synthesis C-terminal, score 7e-47 637910004100 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 637910004101 MPT binding site; other site 637910004102 trimer interface [polypeptide binding]; other site 637910004103 HMMPfam hit to PF00994, Molybdopterin binding, score 6.7e-44 637910004104 PS01078 Molybdenum cofactor biosynthesis proteins signature 1. 637910004105 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 637910004106 trimer interface [polypeptide binding]; other site 637910004107 dimer interface [polypeptide binding]; other site 637910004108 putative active site [active] 637910004109 HMMPfam hit to PF01967, Molybdopterin cofactor biosynthesis MoaC region, score 4.8e-96 637910004110 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 637910004111 MoaE interaction surface [polypeptide binding]; other site 637910004112 MoeB interaction surface [polypeptide binding]; other site 637910004113 thiocarboxylated glycine; other site 637910004114 HMMPfam hit to PF02597, ThiamineS, score 2.3e-29 637910004115 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 637910004116 MoaE homodimer interface [polypeptide binding]; other site 637910004117 MoaD interaction [polypeptide binding]; other site 637910004118 active site residues [active] 637910004119 HMMPfam hit to PF02391, Molybdopterin biosynthesis MoaE, score 3.2e-60 637910004120 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 637910004121 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 637910004122 HMMPfam hit to PF01027, Protein of unknown function UPF0005, score 5.2e-49 637910004123 7 transmembrane helices predicted for ROD07871 by TMHMM2.0 at aa 20-42, 57-76, 88-107, 112-131, 138-160, 165-184 and 209-231 637910004124 Predicted integral membrane protein [Function unknown]; Region: COG0392 637910004125 8 transmembrane helices predicted for ROD07881 by TMHMM2.0 at aa 13-30, 50-72, 85-107, 127-149, 162-184, 204-226, 233-255 and 281-303 637910004126 Predicted helix-turn-helix motif with score 1112.000, SD 2.97 at aa 107-128, sequence GMRYRLYSRLGLPGSTITRIFS 637910004127 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910004128 cardiolipin synthase 2; Provisional; Region: PRK11263 637910004129 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 637910004130 putative active site [active] 637910004131 catalytic site [active] 637910004132 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 637910004133 putative active site [active] 637910004134 catalytic site [active] 637910004135 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 1.4 637910004136 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 6.1e-09 637910004137 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 637910004138 putative catalytic site [active] 637910004139 putative metal binding site [ion binding]; other site 637910004140 putative phosphate binding site [ion binding]; other site 637910004141 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 1.4e-30 637910004142 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 637910004143 4 transmembrane helices predicted for ROD07911 by TMHMM2.0 at aa 13-32, 36-58, 79-96 and 100-119 637910004144 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 637910004145 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 637910004146 6 transmembrane helices predicted for ROD07921 by TMHMM2.0 at aa 24-46, 173-195, 223-245, 255-277, 284-303 and 338-360 637910004147 HMMPfam hit to PF01061, ABC-2 type transporter score 2.1e-42 637910004148 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 637910004149 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 637910004150 6 transmembrane helices predicted for ROD07931 by TMHMM2.0 at aa 27-49, 182-204, 231-253, 263-285, 292-314 and 346-368 637910004151 HMMPfam hit to PF01061, ABC-2 type transporter score 3.9e-25 637910004152 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 637910004153 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 637910004154 Walker A/P-loop; other site 637910004155 ATP binding site [chemical binding]; other site 637910004156 Q-loop/lid; other site 637910004157 ABC transporter signature motif; other site 637910004158 Walker B; other site 637910004159 D-loop; other site 637910004160 H-loop/switch region; other site 637910004161 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 637910004162 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 637910004163 Walker A/P-loop; other site 637910004164 ATP binding site [chemical binding]; other site 637910004165 Q-loop/lid; other site 637910004166 ABC transporter signature motif; other site 637910004167 Walker B; other site 637910004168 D-loop; other site 637910004169 H-loop/switch region; other site 637910004170 HMMPfam hit to PF00005, ABC transporter related, score 1.3e-46 637910004171 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004172 HMMPfam hit to PF00005, ABC transporter related, score 1.4e-40 637910004173 PS00211 ABC transporters family signature. 637910004174 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004175 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 637910004176 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637910004177 HlyD family secretion protein; Region: HlyD_3; pfam13437 637910004178 HMMPfam hit to PF00529, Secretion protein HlyD, score 8.9e-18 637910004179 1 transmembrane helix predicted for ROD07951 by TMHMM2.0 at aa 5-27 637910004180 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 637910004181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637910004182 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 637910004183 HMMPfam hit to PF09209, Transcriptional regulator, YbiH, C-terminal, score 1.3e-40 637910004184 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 1.1e-16 637910004185 PS01081 Bacterial regulatory proteins, tetR family signature. 637910004186 Predicted helix-turn-helix motif with score 1086.000, SD 2.89 at aa 32-53, sequence ATTRDIAAQAGQNIAAITYYFG 637910004187 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 637910004188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910004189 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 637910004190 dimerization interface [polypeptide binding]; other site 637910004191 substrate binding pocket [chemical binding]; other site 637910004192 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.1e-26 637910004193 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 4.5e-20 637910004194 PS00044 Bacterial regulatory proteins, lysR family signature. 637910004195 Predicted helix-turn-helix motif with score 1315.000, SD 3.67 at aa 28-49, sequence GSLNTAAENLNITASAVSHQIA 637910004196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910004197 D-galactonate transporter; Region: 2A0114; TIGR00893 637910004198 putative substrate translocation pore; other site 637910004199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910004200 12 transmembrane helices predicted for ROD07981 by TMHMM2.0 at aa 17-34, 58-80, 87-109, 113-135, 147-169, 173-195, 264-286, 296-318, 331-353, 358-380, 387-409 and 419-438 637910004201 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 4.6e-68 637910004202 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 637910004203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637910004204 NAD(P) binding site [chemical binding]; other site 637910004205 active site 637910004206 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 2.6e-31 637910004207 PS00061 Short-chain dehydrogenases/reductases family signature. 637910004208 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 637910004209 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637910004210 TPP-binding site [chemical binding]; other site 637910004211 dimer interface [polypeptide binding]; other site 637910004212 HMMPfam hit to PF00456, Transketolase, N-terminal, score 2.2e-16 637910004213 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 637910004214 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637910004215 PYR/PP interface [polypeptide binding]; other site 637910004216 dimer interface [polypeptide binding]; other site 637910004217 TPP binding site [chemical binding]; other site 637910004218 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637910004219 HMMPfam hit to PF02779, Transketolase, central region, score 9.8e-45 637910004220 HMMPfam hit to PF02780, Transketolase, C-terminal, score 1.1e-31 637910004221 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 637910004222 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 637910004223 putative catalytic cysteine [active] 637910004224 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 637910004225 putative active site [active] 637910004226 metal binding site [ion binding]; metal-binding site 637910004227 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 9.5e-08 637910004228 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 1.3e-237 637910004229 PS00913 Iron-containing alcohol dehydrogenases signature 1. 637910004230 PS00060 Iron-containing alcohol dehydrogenases signature 2. 637910004231 helicase 45; Provisional; Region: PTZ00424 637910004232 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 637910004233 ATP binding site [chemical binding]; other site 637910004234 Mg++ binding site [ion binding]; other site 637910004235 motif III; other site 637910004236 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637910004237 nucleotide binding region [chemical binding]; other site 637910004238 ATP-binding site [chemical binding]; other site 637910004239 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 3.8e-74 637910004240 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004241 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 637910004242 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 4.9e-34 637910004243 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 637910004244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 637910004245 DEAD_2; Region: DEAD_2; pfam06733 637910004246 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 637910004247 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004248 glycosyl transferase family protein; Provisional; Region: PRK08136 637910004249 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 637910004250 HMMPfam hit to PF02885, Glycosyl transferase, family 3, score 7e-26 637910004251 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 637910004252 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 1.6e-35 637910004253 1 transmembrane helix predicted for ROD08061 by TMHMM2.0 at aa 7-29 637910004254 hypothetical protein; Provisional; Region: PRK11019 637910004255 HMMPfam hit to PF01258, Zinc finger, DksA/TraR C4-type, score 3.5e-31 637910004256 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 637910004257 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 637910004258 HMMPfam hit to PF05971, Protein of unknown function DUF890, score 1.7e-210 637910004259 putative mechanosensitive channel protein; Provisional; Region: PRK11465 637910004260 Mechanosensitive ion channel; Region: MS_channel; pfam00924 637910004261 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 4.5e-61 637910004262 10 transmembrane helices predicted for ROD08091 by TMHMM2.0 at aa 138-160, 181-203, 218-240, 268-287, 292-314, 335-357, 372-394, 429-451, 466-488 and 509-531 637910004263 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 637910004264 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 637910004265 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637910004266 Walker A/P-loop; other site 637910004267 ATP binding site [chemical binding]; other site 637910004268 Q-loop/lid; other site 637910004269 ABC transporter signature motif; other site 637910004270 Walker B; other site 637910004271 D-loop; other site 637910004272 H-loop/switch region; other site 637910004273 HMMPfam hit to PF00005, ABC transporter related, score 1.4e-69 637910004274 PS00211 ABC transporters family signature. 637910004275 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004276 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637910004277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910004278 dimer interface [polypeptide binding]; other site 637910004279 conserved gate region; other site 637910004280 putative PBP binding loops; other site 637910004281 ABC-ATPase subunit interface; other site 637910004282 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.5e-35 637910004283 3 transmembrane helices predicted for ROD08111 by TMHMM2.0 at aa 20-42, 54-76 and 187-209 637910004284 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910004285 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 637910004286 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637910004287 substrate binding pocket [chemical binding]; other site 637910004288 membrane-bound complex binding site; other site 637910004289 hinge residues; other site 637910004290 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 1.1e-92 637910004291 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 637910004292 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 637910004293 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910004294 HMMPfam hit to PF01609, Transposase, IS4-like, score 3.8e-27 637910004295 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 637910004296 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 637910004297 dimerization interface [polypeptide binding]; other site 637910004298 DPS ferroxidase diiron center [ion binding]; other site 637910004299 ion pore; other site 637910004300 HMMPfam hit to PF00210, Ferritin and Dps, score 8.7e-13 637910004301 PS00819 Dps protein family signature 2. 637910004302 PS00818 Dps protein family signature 1. 637910004303 threonine and homoserine efflux system; Provisional; Region: PRK10532 637910004304 EamA-like transporter family; Region: EamA; pfam00892 637910004305 10 transmembrane helices predicted for ROD08151 by TMHMM2.0 at aa 9-31, 37-59, 72-89, 93-115, 122-139, 144-166, 179-198, 203-225, 238-257 and 261-283 637910004306 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 1.2e-21 637910004307 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910004308 outer membrane protein X; Provisional; Region: ompX; PRK09408 637910004309 HMMPfam hit to PF06316, Virulence-related outer membrane protein, score 3.1e-18 637910004310 1 transmembrane helix predicted for ROD08161 by TMHMM2.0 at aa 7-29 637910004311 PS00694 Enterobacterial virulence outer membrane protein signature 1. 637910004312 PS00695 Enterobacterial virulence outer membrane protein signature 2. 637910004313 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 637910004314 Sulfatase; Region: Sulfatase; pfam00884 637910004315 HMMPfam hit to PF00884, Sulphatase, score 1.1e-70 637910004316 4 transmembrane helices predicted for ROD08171 by TMHMM2.0 at aa 32-54, 63-85, 105-127 and 144-166 637910004317 1 transmembrane helix predicted for ROD08181 by TMHMM2.0 at aa 44-66 637910004318 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910004319 manganese transport regulator MntR; Provisional; Region: PRK11050 637910004320 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 637910004321 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 637910004322 HMMPfam hit to PF01325, Iron dependent repressor, score 3e-07 637910004323 Predicted helix-turn-helix motif with score 1524.000, SD 4.38 at aa 55-76, sequence ARQVDMAARLGVSQPTVAKMLK 637910004324 HMMPfam hit to PF02742, Iron dependent repressor, score 3.8e-08 637910004325 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 637910004326 transmembrane helices; other site 637910004327 Citrate transporter; Region: CitMHS; pfam03600 637910004328 HMMPfam hit to PF03600, Divalent ion symporter, score 5.8e-07 637910004329 10 transmembrane helices predicted for ROD08201 by TMHMM2.0 at aa 13-32, 42-64, 84-106, 160-182, 202-219, 223-242, 249-268, 283-305, 312-334 and 344-366 637910004330 L,D-transpeptidase; Provisional; Region: PRK10260 637910004331 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637910004332 HMMPfam hit to PF03734, ErfK/YbiS/YcfS/YnhG, score 9.2e-68 637910004333 1 transmembrane helix predicted for ROD08211 by TMHMM2.0 at aa 7-29 637910004334 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 637910004335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910004336 Walker A/P-loop; other site 637910004337 ATP binding site [chemical binding]; other site 637910004338 Q-loop/lid; other site 637910004339 ABC transporter signature motif; other site 637910004340 Walker B; other site 637910004341 D-loop; other site 637910004342 H-loop/switch region; other site 637910004343 ABC transporter; Region: ABC_tran_2; pfam12848 637910004344 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637910004345 HMMPfam hit to PF00005, ABC transporter related, score 4.1e-40 637910004346 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004347 HMMPfam hit to PF00005, ABC transporter related, score 1.9e-44 637910004348 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004349 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 637910004350 1 transmembrane helix predicted for ROD08231 by TMHMM2.0 at aa 159-181 637910004351 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 637910004352 HMMPfam hit to PF07350, Protein of unknown function DUF1479, score 0 637910004353 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 637910004354 6 transmembrane helices predicted for ROD08251 by TMHMM2.0 at aa 7-29, 44-66, 91-113, 123-145, 483-502 and 506-528 637910004355 HMMPfam hit to PF01435, Peptidase M48, Ste24p, score 0.0015 637910004356 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 637910004357 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 637910004358 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910004359 active site 637910004360 motif I; other site 637910004361 motif II; other site 637910004362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910004363 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 7e-70 637910004364 PS01229 Hypothetical cof family signature 2. 637910004365 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 637910004366 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 637910004367 dimer interface [polypeptide binding]; other site 637910004368 active site 637910004369 glycine loop; other site 637910004370 HMMPfam hit to PF01228, Formate C-acetyltransferase glycine radical, score 2.3e-19 637910004371 PS00850 Glycine radical signature. 637910004372 HMMPfam hit to PF02901, Pyruvate formate-lyase, PFL, score 0 637910004373 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 637910004374 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910004375 FeS/SAM binding site; other site 637910004376 HMMPfam hit to PF04055, Radical SAM, score 1.1e-10 637910004377 PS01087 Radical activating enzymes signature. 637910004378 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 637910004379 active site 637910004380 intersubunit interactions; other site 637910004381 catalytic residue [active] 637910004382 HMMPfam hit to PF00923, Transaldolase, score 1.7e-94 637910004383 PS01054 Transaldolase signature 1. 637910004384 PS00958 Transaldolase active site. 637910004385 putative transposase; Provisional; Region: PRK09857 637910004386 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 637910004387 HMMPfam hit to PF04754, Transposase (), YhgA-like, score 1.1e-191 637910004388 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 637910004389 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 637910004390 ATP binding site [chemical binding]; other site 637910004391 substrate interface [chemical binding]; other site 637910004392 HMMPfam hit to PF05237, MoeZ/MoeB, score 5.8e-34 637910004393 HMMPfam hit to PF00899, UBA/THIF-type NAD/FAD binding fold, score 3.6e-60 637910004394 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910004395 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 637910004396 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 637910004397 dimer interface [polypeptide binding]; other site 637910004398 putative functional site; other site 637910004399 putative MPT binding site; other site 637910004400 HMMPfam hit to PF03454, MoeA, C-terminal, domain IV, score 1.6e-26 637910004401 HMMPfam hit to PF00994, Molybdopterin binding, score 4e-52 637910004402 PS01079 Molybdenum cofactor biosynthesis proteins signature 2. 637910004403 HMMPfam hit to PF03453, MoeA, N-terminal, domain I and II, score 9.9e-82 637910004404 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 637910004405 catalytic nucleophile [active] 637910004406 HMMPfam hit to PF01112, Peptidase T2, asparaginase 2, score 1.2e-174 637910004407 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910004408 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 637910004409 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637910004410 Walker A/P-loop; other site 637910004411 ATP binding site [chemical binding]; other site 637910004412 Q-loop/lid; other site 637910004413 ABC transporter signature motif; other site 637910004414 Walker B; other site 637910004415 D-loop; other site 637910004416 H-loop/switch region; other site 637910004417 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 637910004418 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637910004419 Walker A/P-loop; other site 637910004420 ATP binding site [chemical binding]; other site 637910004421 Q-loop/lid; other site 637910004422 ABC transporter signature motif; other site 637910004423 Walker B; other site 637910004424 D-loop; other site 637910004425 H-loop/switch region; other site 637910004426 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 637910004427 HMMPfam hit to PF00005, ABC transporter related, score 3.2e-61 637910004428 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004429 PS00211 ABC transporters family signature. 637910004430 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter C-terminal, score 1.5e-06 637910004431 HMMPfam hit to PF00005, ABC transporter related, score 6.5e-64 637910004432 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004433 PS00211 ABC transporters family signature. 637910004434 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter C-terminal, score 1.1e-07 637910004435 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 637910004436 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 637910004437 1 transmembrane helix predicted for ROD08351 by TMHMM2.0 at aa 20-42 637910004438 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 8.8e-95 637910004439 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 637910004440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910004441 dimer interface [polypeptide binding]; other site 637910004442 conserved gate region; other site 637910004443 putative PBP binding loops; other site 637910004444 ABC-ATPase subunit interface; other site 637910004445 6 transmembrane helices predicted for ROD08361 by TMHMM2.0 at aa 9-31, 101-123, 135-157, 172-189, 227-249 and 278-300 637910004446 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.9e-58 637910004447 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910004448 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 637910004449 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 637910004450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910004451 dimer interface [polypeptide binding]; other site 637910004452 conserved gate region; other site 637910004453 putative PBP binding loops; other site 637910004454 ABC-ATPase subunit interface; other site 637910004455 6 transmembrane helices predicted for ROD08371 by TMHMM2.0 at aa 39-61, 107-129, 136-158, 163-185, 209-231 and 266-288 637910004456 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.3e-47 637910004457 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910004458 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 637910004459 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 637910004460 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910004461 FeS/SAM binding site; other site 637910004462 HMMPfam hit to PF04055, Radical SAM, score 8.3e-29 637910004463 PS01278 Uncharacterized protein family UPF0004 signature. 637910004464 HMMPfam hit to PF00919, Protein of unknown function UPF0004, N-terminal, score 3.3e-42 637910004465 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 637910004466 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 637910004467 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 637910004468 HMMPfam hit to PF07995, Glucose sorbosone dehydrogenase, score 1.5e-67 637910004469 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637910004470 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 637910004471 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 637910004472 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 8.4e-18 637910004473 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 637910004474 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637910004475 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910004476 DNA binding site [nucleotide binding] 637910004477 domain linker motif; other site 637910004478 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 637910004479 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 3.2e-11 637910004480 Predicted helix-turn-helix motif with score 2032.000, SD 6.11 at aa 7-28, sequence ITMSDIAREAGVSQATVSLVLN 637910004481 PS00356 Bacterial regulatory proteins, lacI family signature. 637910004482 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 4.8e-16 637910004483 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 637910004484 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 637910004485 putative C-terminal domain interface [polypeptide binding]; other site 637910004486 putative GSH binding site (G-site) [chemical binding]; other site 637910004487 putative dimer interface [polypeptide binding]; other site 637910004488 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 637910004489 putative N-terminal domain interface [polypeptide binding]; other site 637910004490 putative dimer interface [polypeptide binding]; other site 637910004491 putative substrate binding pocket (H-site) [chemical binding]; other site 637910004492 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 7e-14 637910004493 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 2.6e-10 637910004494 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 637910004495 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 637910004496 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 637910004497 HMMPfam hit to PF00768, Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, score 4.5e-151 637910004498 HMMPfam hit to PF07943, Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal, score 2.3e-38 637910004499 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 637910004500 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 637910004501 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637910004502 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 1.4e-70 637910004503 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 9.9e-20 637910004504 Predicted helix-turn-helix motif with score 2038.000, SD 6.13 at aa 22-43, sequence LHLKEAAALLGVSEMTIRRDLN 637910004505 PS00894 Bacterial regulatory proteins, deoR family signature. 637910004506 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 637910004507 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 637910004508 active site 637910004509 HMMPfam hit to PF01569, Phosphatidic acid phosphatase type 2-like, score 6.4e-29 637910004510 4 transmembrane helices predicted for ROD08471 by TMHMM2.0 at aa 26-48, 60-82, 126-148 and 155-172 637910004511 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910004512 pseudogene, truncated by frameshift mutation 637910004513 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 2.3e-25 637910004514 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 637910004515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910004516 active site 637910004517 motif I; other site 637910004518 motif II; other site 637910004519 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910004520 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 3.8e-67 637910004521 PS01229 Hypothetical cof family signature 2. 637910004522 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 637910004523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910004524 putative substrate translocation pore; other site 637910004525 12 transmembrane helices predicted for ROD08511 by TMHMM2.0 at aa 12-34, 49-71, 78-100, 104-126, 146-168, 172-191, 211-233, 253-275, 282-301, 305-327, 340-362 and 367-389 637910004526 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 9.5e-28 637910004527 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 637910004528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637910004529 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 637910004530 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 6.2e-11 637910004531 Predicted helix-turn-helix motif with score 990.000, SD 2.56 at aa 29-50, sequence VTHRKIAAIADVPLGSLTYYFS 637910004532 putative transporter; Provisional; Region: PRK04972 637910004533 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 637910004534 TrkA-C domain; Region: TrkA_C; pfam02080 637910004535 TrkA-C domain; Region: TrkA_C; pfam02080 637910004536 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 637910004537 9 transmembrane helices predicted for ROD08541 by TMHMM2.0 at aa 13-35, 64-86, 93-115, 159-181, 383-402, 406-428, 449-471, 476-498 and 535-557 637910004538 HMMPfam hit to PF06826, YidE/YbjL duplication, score 3.2e-61 637910004539 HMMPfam hit to PF02080, TrkA-C, score 6.3e-12 637910004540 HMMPfam hit to PF02080, TrkA-C, score 2.6e-11 637910004541 HMMPfam hit to PF06826, YidE/YbjL duplication, score 6.2e-66 637910004542 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 637910004543 4 transmembrane helices predicted for ROD08551 by TMHMM2.0 at aa 7-26, 36-55, 62-84 and 94-116 637910004544 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 637910004545 GSH binding site [chemical binding]; other site 637910004546 catalytic residues [active] 637910004547 HMMPfam hit to PF00462, Glutaredoxin, score 2.9e-15 637910004548 PS00195 Glutaredoxin active site. 637910004549 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 637910004550 dimer interface [polypeptide binding]; other site 637910004551 FMN binding site [chemical binding]; other site 637910004552 NADPH bind site [chemical binding]; other site 637910004553 HMMPfam hit to PF00881, Nitroreductase, score 3.3e-38 637910004554 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 637910004555 RimK-like ATP-grasp domain; Region: RimK; pfam08443 637910004556 HMMPfam hit to PF08443, ATP-grasp fold, RimK-type, score 2.3e-114 637910004557 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 637910004558 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 637910004559 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 637910004560 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 3.9e-11 637910004561 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 637910004562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910004563 Walker A/P-loop; other site 637910004564 ATP binding site [chemical binding]; other site 637910004565 Q-loop/lid; other site 637910004566 ABC transporter signature motif; other site 637910004567 Walker B; other site 637910004568 D-loop; other site 637910004569 H-loop/switch region; other site 637910004570 TOBE domain; Region: TOBE_2; pfam08402 637910004571 HMMPfam hit to PF00005, ABC transporter related, score 9.6e-65 637910004572 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004573 PS00211 ABC transporters family signature. 637910004574 HMMPfam hit to PF08402, Transport-associated OB, type 2, score 1.2e-25 637910004575 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 637910004576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910004577 dimer interface [polypeptide binding]; other site 637910004578 conserved gate region; other site 637910004579 putative PBP binding loops; other site 637910004580 ABC-ATPase subunit interface; other site 637910004581 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 637910004582 6 transmembrane helices predicted for ROD08621 by TMHMM2.0 at aa 31-52, 100-122, 135-157, 185-207, 228-250 and 284-306 637910004583 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.5e-30 637910004584 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910004585 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 637910004586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910004587 dimer interface [polypeptide binding]; other site 637910004588 conserved gate region; other site 637910004589 putative PBP binding loops; other site 637910004590 ABC-ATPase subunit interface; other site 637910004591 6 transmembrane helices predicted for ROD08631 by TMHMM2.0 at aa 13-35, 69-91, 104-126, 141-163, 184-206 and 242-264 637910004592 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 0.0003 637910004593 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910004594 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910004595 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 637910004596 3 transmembrane helices predicted for ROD08641 by TMHMM2.0 at aa 20-42, 57-79 and 86-108 637910004597 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 637910004598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910004599 S-adenosylmethionine binding site [chemical binding]; other site 637910004600 HMMPfam hit to PF05958, (Uracil-5)-methyltransferase, score 1.4e-06 637910004601 PS01230 RNA methyltransferase trmA family signature 1. 637910004602 PS01231 RNA methyltransferase trmA family signature 2. 637910004603 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 637910004604 HMMPfam hit to PF04215, sugar-specific permease, SgaT/UlaA, score 4e-86 637910004605 10 transmembrane helices predicted for ROD08671 by TMHMM2.0 at aa 5-24, 31-53, 91-113, 134-156, 160-182, 221-243, 258-280, 318-340, 344-365 and 372-394 637910004606 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 637910004607 active site 637910004608 P-loop; other site 637910004609 phosphorylation site [posttranslational modification] 637910004610 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 6.9e-07 637910004611 1 transmembrane helix predicted for ROD08681 by TMHMM2.0 at aa 7-25 637910004612 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 637910004613 Sulfatase; Region: Sulfatase; cl17466 637910004614 HMMPfam hit to PF00884, Sulphatase, score 5.2e-14 637910004615 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 637910004616 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637910004617 substrate binding pocket [chemical binding]; other site 637910004618 membrane-bound complex binding site; other site 637910004619 hinge residues; other site 637910004620 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 4e-101 637910004621 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 637910004622 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637910004623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910004624 dimer interface [polypeptide binding]; other site 637910004625 conserved gate region; other site 637910004626 putative PBP binding loops; other site 637910004627 ABC-ATPase subunit interface; other site 637910004628 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 4.6e-08 637910004629 5 transmembrane helices predicted for ROD08711 by TMHMM2.0 at aa 15-37, 46-68, 83-105, 155-174 and 189-211 637910004630 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637910004631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910004632 dimer interface [polypeptide binding]; other site 637910004633 conserved gate region; other site 637910004634 putative PBP binding loops; other site 637910004635 ABC-ATPase subunit interface; other site 637910004636 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 9.2e-17 637910004637 5 transmembrane helices predicted for ROD08721 by TMHMM2.0 at aa 13-35, 45-67, 74-96, 101-118 and 201-223 637910004638 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910004639 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 637910004640 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637910004641 substrate binding pocket [chemical binding]; other site 637910004642 membrane-bound complex binding site; other site 637910004643 hinge residues; other site 637910004644 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 4.7e-96 637910004645 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 637910004646 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 637910004647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910004648 Walker A/P-loop; other site 637910004649 ATP binding site [chemical binding]; other site 637910004650 Q-loop/lid; other site 637910004651 ABC transporter signature motif; other site 637910004652 Walker B; other site 637910004653 D-loop; other site 637910004654 H-loop/switch region; other site 637910004655 HMMPfam hit to PF00005, ABC transporter related, score 1.8e-76 637910004656 PS00211 ABC transporters family signature. 637910004657 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004658 putative lipoprotein; Provisional; Region: PRK10533 637910004659 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910004660 hypothetical protein; Provisional; Region: PRK02877 637910004661 HMMPfam hit to PF01906, Protein of unknown function DUF74, score 4.8e-64 637910004662 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 637910004663 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 637910004664 amidase catalytic site [active] 637910004665 Zn binding residues [ion binding]; other site 637910004666 substrate binding site [chemical binding]; other site 637910004667 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910004668 HMMPfam hit to PF01510, N-acetylmuramoyl-L-alanine amidase, family 2, score 1.1e-42 637910004669 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 637910004670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637910004671 NAD(P) binding site [chemical binding]; other site 637910004672 active site 637910004673 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 1.8e-19 637910004674 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 637910004675 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 637910004676 putative NAD(P) binding site [chemical binding]; other site 637910004677 putative active site [active] 637910004678 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 637910004679 1 transmembrane helix predicted for ROD08791 by TMHMM2.0 at aa 437-459 637910004680 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 4.8e-11 637910004681 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 637910004682 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 637910004683 tetramer interface [polypeptide binding]; other site 637910004684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910004685 catalytic residue [active] 637910004686 HMMPfam hit to PF01212, Aromatic amino acid beta-eliminating lyase/threonine aldolase, score 8.6e-154 637910004687 pyruvate dehydrogenase; Provisional; Region: PRK09124 637910004688 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 637910004689 PYR/PP interface [polypeptide binding]; other site 637910004690 dimer interface [polypeptide binding]; other site 637910004691 tetramer interface [polypeptide binding]; other site 637910004692 TPP binding site [chemical binding]; other site 637910004693 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637910004694 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 637910004695 TPP-binding site [chemical binding]; other site 637910004696 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-terminal TPP-binding, score 2.5e-61 637910004697 PS00187 Thiamine pyrophosphate enzymes signature. 637910004698 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central region, score 4.5e-47 637910004699 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-terminal TPP binding region, score 2.5e-81 637910004700 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 637910004701 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 637910004702 FAD binding pocket [chemical binding]; other site 637910004703 FAD binding motif [chemical binding]; other site 637910004704 phosphate binding motif [ion binding]; other site 637910004705 beta-alpha-beta structure motif; other site 637910004706 NAD binding pocket [chemical binding]; other site 637910004707 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637910004708 catalytic loop [active] 637910004709 iron binding site [ion binding]; other site 637910004710 HMMPfam hit to PF00111, Ferredoxin, score 3e-20 637910004711 HMMPfam hit to PF00175, Oxidoreductase FAD/NAD(P)-binding, score 4.4e-08 637910004712 HMMPfam hit to PF00970, Oxidoreductase FAD-binding region, score 2.8e-09 637910004713 hybrid cluster protein; Provisional; Region: PRK05290 637910004714 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637910004715 ACS interaction site; other site 637910004716 CODH interaction site; other site 637910004717 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 637910004718 hybrid metal cluster; other site 637910004719 HMMPfam hit to PF03063, Prismane, score 1.4e-258 637910004720 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004721 Predicted membrane protein [Function unknown]; Region: COG2431 637910004722 HMMPfam hit to PF03956, Protein of unknown function DUF340, prokaryotic membrane, score 9.9e-85 637910004723 8 transmembrane helices predicted for ROD08841 by TMHMM2.0 at aa 4-20, 32-51, 61-83, 111-133, 138-155, 167-189, 204-226 and 275-297 637910004724 PS00041 Bacterial regulatory proteins, araC family signature. 637910004725 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 637910004726 amphipathic channel; other site 637910004727 Asn-Pro-Ala signature motifs; other site 637910004728 6 transmembrane helices predicted for ROD08851 by TMHMM2.0 at aa 7-29, 33-55, 81-103, 130-152, 159-181 and 205-227 637910004729 HMMPfam hit to PF00230, major intrinsic protein, score 4.6e-51 637910004730 PS00221 MIP family signature. 637910004731 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910004732 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 637910004733 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 637910004734 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 637910004735 putative active site [active] 637910004736 putative metal-binding site [ion binding]; other site 637910004737 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004738 Protein of unknown function (DUF535); Region: DUF535; pfam04393 637910004739 HMMPfam hit to PF04393, Protein of unknown function DUF535, score 9.1e-92 637910004740 macrolide transporter subunit MacA; Provisional; Region: PRK11578 637910004741 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637910004742 HlyD family secretion protein; Region: HlyD_3; pfam13437 637910004743 1 transmembrane helix predicted for ROD08891 by TMHMM2.0 at aa 13-30 637910004744 HMMPfam hit to PF00529, Secretion protein HlyD, score 5.9e-10 637910004745 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 637910004746 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637910004747 Walker A/P-loop; other site 637910004748 ATP binding site [chemical binding]; other site 637910004749 Q-loop/lid; other site 637910004750 ABC transporter signature motif; other site 637910004751 Walker B; other site 637910004752 D-loop; other site 637910004753 H-loop/switch region; other site 637910004754 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637910004755 FtsX-like permease family; Region: FtsX; pfam02687 637910004756 HMMPfam hit to PF00005, ABC transporter related, score 1.1e-57 637910004757 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004758 PS00211 ABC transporters family signature. 637910004759 4 transmembrane helices predicted for ROD08901 by TMHMM2.0 at aa 273-295, 527-549, 572-594 and 609-631 637910004760 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 5.5e-56 637910004761 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 637910004762 DNA-binding site [nucleotide binding]; DNA binding site 637910004763 RNA-binding motif; other site 637910004764 HMMPfam hit to PF00313, Cold-shock protein, DNA-binding, score 1.3e-39 637910004765 PS00352 'Cold-shock' DNA-binding domain signature. 637910004766 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 637910004767 HMMPfam hit to PF02617, Adaptor protein ClpS, core, score 2.9e-49 637910004768 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 637910004769 Clp amino terminal domain; Region: Clp_N; pfam02861 637910004770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910004771 Walker A motif; other site 637910004772 ATP binding site [chemical binding]; other site 637910004773 Walker B motif; other site 637910004774 arginine finger; other site 637910004775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910004776 Walker A motif; other site 637910004777 ATP binding site [chemical binding]; other site 637910004778 Walker B motif; other site 637910004779 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 637910004780 HMMPfam hit to PF02861, Clp, N-terminal, score 7.5e-17 637910004781 HMMPfam hit to PF00004, AAA ATPase, core, score 5.3e-22 637910004782 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004783 PS00870 Chaperonins clpA/B signature 1. 637910004784 HMMPfam hit to PF07724, ATPase AAA-2, score 1.7e-88 637910004785 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004786 PS00871 Chaperonins clpA/B signature 2. 637910004787 CR_GI2 637910004788 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 637910004789 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637910004790 HlyD family secretion protein; Region: HlyD_3; pfam13437 637910004791 PS00543 HlyD family secretion proteins signature. 637910004792 HMMPfam hit to PF00529, Secretion protein HlyD, score 8.8e-06 637910004793 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 637910004794 HMMPfam hit to PF00529, Secretion protein HlyD, score 1.1e-08 637910004795 1 transmembrane helix predicted for ROD08941 by TMHMM2.0 at aa 17-39 637910004796 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 637910004797 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637910004798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910004799 Walker A/P-loop; other site 637910004800 ATP binding site [chemical binding]; other site 637910004801 Q-loop/lid; other site 637910004802 ABC transporter signature motif; other site 637910004803 Walker B; other site 637910004804 D-loop; other site 637910004805 H-loop/switch region; other site 637910004806 HMMPfam hit to PF00005, ABC transporter related, score 2e-55 637910004807 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004808 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 6.5e-17 637910004809 3 transmembrane helices predicted for ROD08951 by TMHMM2.0 at aa 170-192, 207-224 and 294-316 637910004810 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 637910004811 HMMPfam hit to PF02321, Outer membrane efflux protein, score 7.3e-16 637910004812 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.9e-20 637910004813 pseudogene, type I secreted protein, disrupted by prophage CRP99 insertion 637910004814 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 92 637910004815 prophage CRP99 637910004816 multiple promoter invertase; Provisional; Region: mpi; PRK13413 637910004817 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 637910004818 catalytic residues [active] 637910004819 catalytic nucleophile [active] 637910004820 Presynaptic Site I dimer interface [polypeptide binding]; other site 637910004821 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 637910004822 Synaptic Flat tetramer interface [polypeptide binding]; other site 637910004823 Synaptic Site I dimer interface [polypeptide binding]; other site 637910004824 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637910004825 DNA-binding interface [nucleotide binding]; DNA binding site 637910004826 HMMPfam hit to PF02796, Resolvase, helix-turn-helix region, score 1.1e-12 637910004827 Predicted helix-turn-helix motif with score 1805.000, SD 5.33 at aa 160-181, sequence HTRKQLSIIYDVGLSTLYRYFP 637910004828 HMMPfam hit to PF00239, Resolvase, N-terminal, score 5e-66 637910004829 PS00398 Site-specific recombinases signature 2. 637910004830 PS00397 Site-specific recombinases active site. 637910004831 invertible tail fibre region of prophage CRP99 637910004832 pseudogene, alternative tail fibre tip, disrupted by ISCro1 insertion 637910004833 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910004834 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910004835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910004836 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910004837 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910004838 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910004839 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910004840 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910004841 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910004842 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910004843 Transposase; Region: HTH_Tnp_1; pfam01527 637910004844 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910004845 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910004846 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910004847 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 637910004848 HMMPfam hit to PF02413, Phage tail assembly chaperone gp38, score 4.9e-36 637910004849 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 637910004850 HMMPfam hit to PF02413, Phage tail assembly chaperone gp38, score 6.8e-43 637910004851 Phage Tail Collar Domain; Region: Collar; pfam07484 637910004852 HMMPfam hit to PF07484, Phage Tail Collar, score 1.6e-20 637910004853 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 637910004854 Baseplate J-like protein; Region: Baseplate_J; cl01294 637910004855 HMMPfam hit to PF04865, Phage baseplate assembly predicted J-like, score 3.5e-129 637910004856 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 637910004857 HMMPfam hit to PF04965, GPW/gp25, score 7.3e-27 637910004858 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 637910004859 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 637910004860 HMMPfam hit to PF04717, Phage baseplate assembly protein V, score 3.9e-46 637910004861 Phage protein D [General function prediction only]; Region: COG3500 637910004862 HMMPfam hit to PF05954, Phage late control D, score 2.7e-179 637910004863 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 637910004864 HMMPfam hit to PF05489, Phage tail protein X, score 1.9e-27 637910004865 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 637910004866 PS00012 Phosphopantetheine attachment site. 637910004867 HMMPfam hit to PF06995, Phage P2 GpU, score 1e-31 637910004868 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 637910004869 2 transmembrane helices predicted for ROD09121 by TMHMM2.0 at aa 573-595 and 616-638 637910004870 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 637910004871 Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; pfam13876 637910004872 Phage tail tube protein FII; Region: Phage_tube; cl01390 637910004873 HMMPfam hit to PF04985, Phage major tail tube protein, score 2.8e-09 637910004874 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 637910004875 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 637910004876 HMMPfam hit to PF04984, Phage tail sheath protein, score 5.9e-189 637910004877 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004878 Gp37 protein; Region: Gp37; pfam09646 637910004879 Protein of unknown function (DUF1320); Region: DUF1320; pfam07030 637910004880 HMMPfam hit to PF07030, Protein of unknown function DUF1320, score 3.6e-63 637910004881 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 637910004882 HMMPfam hit to PF05069, Phage virion morphogenesis ( tail completion) protein, score 1.6e-26 637910004883 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 637910004884 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 637910004885 HMMPfam hit to PF04233, Phage head morphogenesis protein, SPP1 gp7, score 8.4e-45 637910004886 Protein of unknown function (DUF935); Region: DUF935; pfam06074 637910004887 HMMPfam hit to PF06074, Protein of unknown function DUF935, score 3.4e-230 637910004888 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 637910004889 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 637910004890 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 637910004891 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 637910004892 1 transmembrane helix predicted for ROD09291 by TMHMM2.0 at aa 7-29 637910004893 Predicted helix-turn-helix motif with score 1142.000, SD 3.08 at aa 189-210, sequence ANIIDNAKQCRIWRSQINRLLD 637910004894 1 transmembrane helix predicted for ROD09301 by TMHMM2.0 at aa 10-32 637910004895 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637910004896 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637910004897 catalytic residue [active] 637910004898 HMMPfam hit to PF01464, Lytic transglycosylase-like, catalytic, score 1e-06 637910004899 2 transmembrane helices predicted for ROD09311 by TMHMM2.0 at aa 4-26 and 38-57 637910004900 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 637910004901 3 transmembrane helices predicted for ROD09321 by TMHMM2.0 at aa 16-33, 38-57 and 92-114 637910004902 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 637910004903 HMMPfam hit to PF02086, D12 class N6 adenine-specific DNA methyltransferase, score 9.7e-20 637910004904 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910004905 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 637910004906 HMMPfam hit to PF07022, Bacteriophage CI repressor, score 4.1e-17 637910004907 Predicted helix-turn-helix motif with score 1544.000, SD 4.45 at aa 20-41, sequence DNDSELARALNVNRQTLASWRK 637910004908 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 637910004909 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 637910004910 HMMPfam hit to PF09339, Transcriptional regulator IclR, N-terminal, score 1.4e-08 637910004911 Predicted helix-turn-helix motif with score 1299.000, SD 3.61 at aa 28-49, sequence VSNGELASALGESPANINRALN 637910004912 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 637910004913 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004914 Integrase core domain; Region: rve; pfam00665 637910004915 HMMPfam hit to PF00665, Integrase, catalytic core, score 3.5e-08 637910004916 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 637910004917 Domain of unknown function DUF87; Region: DUF87; pfam01935 637910004918 Predicted helix-turn-helix motif with score 1392.000, SD 3.93 at aa 13-34, sequence IPQAVVARAVAVSEATLAQIVN 637910004919 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004920 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 637910004921 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u2; cd11539 637910004922 metal binding site [ion binding]; metal-binding site 637910004923 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 637910004924 1 transmembrane helix predicted for ROD09442 by TMHMM2.0 at aa 35-57 637910004925 Protein of unknown function (DUF1018); Region: DUF1018; pfam06252 637910004926 HMMPfam hit to PF06252, Protein of unknown function DUF1018, score 2.3e-74 637910004927 Mor transcription activator family; Region: Mor; pfam08765 637910004928 HMMPfam hit to PF08765, Mor transcription activator, score 9.9e-62 637910004929 Predicted helix-turn-helix motif with score 1626.000, SD 4.72 at aa 81-102, sequence RNHHELARKYGVSLQWIYSVVK 637910004930 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 55 637910004931 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 38 637910004932 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 38 637910004933 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 47 637910004934 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 38 637910004935 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 38 637910004936 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 38 637910004937 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637910004938 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910004939 DNA binding residues [nucleotide binding] 637910004940 dimerization interface [polypeptide binding]; other site 637910004941 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 8.5e-13 637910004942 PS00622 Bacterial regulatory proteins, luxR family signature. 637910004943 Predicted helix-turn-helix motif with score 1106.000, SD 2.95 at aa 158-179, sequence YNVQRIAKLMNVSAKTIHAHKY 637910004944 PS00237 G-protein coupled receptors signature. 637910004945 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 637910004946 rRNA binding site [nucleotide binding]; other site 637910004947 predicted 30S ribosome binding site; other site 637910004948 HMMPfam hit to PF01176, S1, IF1 type, score 2.1e-37 637910004949 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 637910004950 HMMPfam hit to PF03588, Leucyl/phenylalanyl-tRNA-protein transferase, score 1.5e-110 637910004951 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 637910004952 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637910004953 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 637910004954 Walker A/P-loop; other site 637910004955 ATP binding site [chemical binding]; other site 637910004956 Q-loop/lid; other site 637910004957 ABC transporter signature motif; other site 637910004958 Walker B; other site 637910004959 D-loop; other site 637910004960 H-loop/switch region; other site 637910004961 HMMPfam hit to PF00005, ABC transporter related, score 2.1e-64 637910004962 PS00211 ABC transporters family signature. 637910004963 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004964 6 transmembrane helices predicted for ROD09501 by TMHMM2.0 at aa 20-42, 47-69, 133-155, 160-182, 246-268 and 278-300 637910004965 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 637910004966 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637910004967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910004968 Walker A/P-loop; other site 637910004969 ATP binding site [chemical binding]; other site 637910004970 Q-loop/lid; other site 637910004971 ABC transporter signature motif; other site 637910004972 Walker B; other site 637910004973 D-loop; other site 637910004974 H-loop/switch region; other site 637910004975 HMMPfam hit to PF00005, ABC transporter related, score 8.9e-68 637910004976 PS00211 ABC transporters family signature. 637910004977 PS00017 ATP/GTP-binding site motif A (P-loop). 637910004978 6 transmembrane helices predicted for ROD09511 by TMHMM2.0 at aa 24-46, 61-80, 137-159, 163-185, 245-267 and 282-304 637910004979 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 2.8e-47 637910004980 thioredoxin reductase; Provisional; Region: PRK10262 637910004981 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637910004982 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637910004983 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 4e-52 637910004984 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 5.7e-26 637910004985 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 637910004986 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 637910004987 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637910004988 putative DNA binding site [nucleotide binding]; other site 637910004989 putative Zn2+ binding site [ion binding]; other site 637910004990 AsnC family; Region: AsnC_trans_reg; pfam01037 637910004991 PS00519 Bacterial regulatory proteins, asnC family signature. 637910004992 HMMPfam hit to PF01037, Bacterial regulatory proteins, AsnC/Lrp, score 5.2e-31 637910004993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910004994 DNA translocase FtsK; Provisional; Region: PRK10263 637910004995 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 637910004996 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 637910004997 5 transmembrane helices predicted for ROD09541 by TMHMM2.0 at aa 22-44, 75-97, 110-132, 137-158 and 165-187 637910004998 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910004999 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005000 HMMPfam hit to PF01580, Cell divisionFtsK/SpoIIIE, score 3.9e-105 637910005001 PS00017 ATP/GTP-binding site motif A (P-loop). 637910005002 periplasmic chaperone LolA; Region: lolA; TIGR00547 637910005003 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 637910005004 HMMPfam hit to PF03548, Outer membrane lipoprotein carrier protein LolA, score 7.9e-77 637910005005 recombination factor protein RarA; Reviewed; Region: PRK13342 637910005006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910005007 Walker A motif; other site 637910005008 ATP binding site [chemical binding]; other site 637910005009 Walker B motif; other site 637910005010 arginine finger; other site 637910005011 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 637910005012 HMMPfam hit to PF00004, AAA ATPase, core, score 1.5e-27 637910005013 PS00017 ATP/GTP-binding site motif A (P-loop). 637910005014 seryl-tRNA synthetase; Provisional; Region: PRK05431 637910005015 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 637910005016 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 637910005017 dimer interface [polypeptide binding]; other site 637910005018 active site 637910005019 motif 1; other site 637910005020 motif 2; other site 637910005021 motif 3; other site 637910005022 HMMPfam hit to PF02403, Seryl-tRNA synthetase, class IIa, N-terminal, score 8.7e-47 637910005023 HMMPfam hit to PF00587, Aminoacyl-tRNA synthetase, class II (G, H, P and S), score 5.5e-66 637910005024 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 637910005025 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 637910005026 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 637910005027 putative [Fe4-S4] binding site [ion binding]; other site 637910005028 putative molybdopterin cofactor binding site [chemical binding]; other site 637910005029 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 637910005030 putative molybdopterin cofactor binding site; other site 637910005031 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 5.1e-19 637910005032 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 637910005033 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 4.6e-185 637910005034 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 637910005035 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 6.5e-37 637910005036 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 637910005037 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 637910005038 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 637910005039 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005040 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 1.7e-07 637910005041 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910005042 PS00190 Cytochrome c family heme-binding site signature. 637910005043 PS00190 Cytochrome c family heme-binding site signature. 637910005044 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 637910005045 HMMPfam hit to PF04976, DMSO reductase anchor subunit (DmsC), score 1.5e-163 637910005046 8 transmembrane helices predicted for ROD09601 by TMHMM2.0 at aa 10-32, 45-67, 82-104, 117-134, 149-171, 178-200, 227-246 and 253-275 637910005047 Isochorismatase family; Region: Isochorismatase; pfam00857 637910005048 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 637910005049 catalytic triad [active] 637910005050 dimer interface [polypeptide binding]; other site 637910005051 conserved cis-peptide bond; other site 637910005052 HMMPfam hit to PF00857, Isochorismatase hydrolase, score 1.3e-63 637910005053 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005054 putative MFS family transporter protein; Provisional; Region: PRK03633 637910005055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910005056 putative substrate translocation pore; other site 637910005057 12 transmembrane helices predicted for ROD09621 by TMHMM2.0 at aa 7-29, 44-66, 73-95, 100-119, 131-150, 160-182, 203-225, 235-257, 264-281, 285-307, 319-341 and 351-368 637910005058 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 7.5e-28 637910005059 PS00237 G-protein coupled receptors signature. 637910005060 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005061 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 637910005062 inner membrane transporter YjeM; Provisional; Region: PRK15238 637910005063 11 transmembrane helices predicted for ROD09631 by TMHMM2.0 at aa 10-29, 36-58, 127-146, 158-180, 195-217, 238-260, 287-309, 341-363, 378-400, 413-435 and 445-467 637910005064 HMMPfam hit to PF00324, Amino acid permease-associated region, score 0.0032 637910005065 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005066 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637910005067 active site 637910005068 phosphorylation site [posttranslational modification] 637910005069 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 3.3e-16 637910005070 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 637910005071 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637910005072 PYR/PP interface [polypeptide binding]; other site 637910005073 dimer interface [polypeptide binding]; other site 637910005074 TPP binding site [chemical binding]; other site 637910005075 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637910005076 HMMPfam hit to PF02780, Transketolase, C-terminal, score 1.1e-05 637910005077 HMMPfam hit to PF02779, Transketolase, central region, score 1.5e-27 637910005078 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637910005079 TPP-binding site [chemical binding]; other site 637910005080 dimer interface [polypeptide binding]; other site 637910005081 HMMPfam hit to PF00456, Transketolase, N-terminal, score 4.1e-40 637910005082 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 637910005083 HMMPfam hit to PF04215, sugar-specific permease, SgaT/UlaA, score 2.8e-114 637910005084 10 transmembrane helices predicted for ROD09671 by TMHMM2.0 at aa 6-28, 48-70, 90-112, 119-138, 148-167, 228-250, 260-282, 308-330, 340-362 and 369-391 637910005085 PS00017 ATP/GTP-binding site motif A (P-loop). 637910005086 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005087 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 637910005088 active site 637910005089 P-loop; other site 637910005090 phosphorylation site [posttranslational modification] 637910005091 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 5e-11 637910005092 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637910005093 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637910005094 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 637910005095 putative active site [active] 637910005096 HMMPfam hit to PF01418, Helix-turn-helix protein RpiR, score 7.2e-11 637910005097 Predicted helix-turn-helix motif with score 1402.000, SD 3.96 at aa 40-61, sequence HTITELADSIETSEGSITRFCR 637910005098 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 0.0056 637910005099 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 637910005100 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910005101 FeS/SAM binding site; other site 637910005102 HMMPfam hit to PF04055, Radical SAM, score 1.3e-27 637910005103 PS01087 Radical activating enzymes signature. 637910005104 PS00190 Cytochrome c family heme-binding site signature. 637910005105 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 637910005106 Pyruvate formate lyase 1; Region: PFL1; cd01678 637910005107 coenzyme A binding site [chemical binding]; other site 637910005108 active site 637910005109 catalytic residues [active] 637910005110 glycine loop; other site 637910005111 HMMPfam hit to PF01228, Formate C-acetyltransferase glycine radical, score 1.8e-63 637910005112 PS00850 Glycine radical signature. 637910005113 HMMPfam hit to PF02901, Pyruvate formate-lyase, PFL, score 0 637910005114 formate transporter; Provisional; Region: PRK10805 637910005115 HMMPfam hit to PF01226, Formate/nitrite transporter score 6.5e-176 637910005116 6 transmembrane helices predicted for ROD09731 by TMHMM2.0 at aa 35-57, 77-99, 119-141, 161-183, 195-217 and 256-278 637910005117 PS01006 Formate and nitrite transporters signature 2. 637910005118 PS01005 Formate and nitrite transporters signature 1. 637910005119 uncharacterized domain; Region: TIGR00702 637910005120 YcaO-like family; Region: YcaO; pfam02624 637910005121 HMMPfam hit to PF02624, YcaO-like, score 5.2e-163 637910005122 Predicted membrane protein [Function unknown]; Region: COG2323 637910005123 3 transmembrane helices predicted for ROD09751 by TMHMM2.0 at aa 15-37, 50-69 and 74-91 637910005124 HMMPfam hit to PF04239, Protein of unknown function DUF421, score 2e-32 637910005125 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 637910005126 homodimer interface [polypeptide binding]; other site 637910005127 substrate-cofactor binding pocket; other site 637910005128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910005129 catalytic residue [active] 637910005130 HMMPfam hit to PF00266, Aminotransferase, class V, score 5.1e-83 637910005131 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 637910005132 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 637910005133 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 637910005134 putative active site [active] 637910005135 HMMPfam hit to PF00275, 3-phosphoshikimate 1-carboxyvinyltransferase, score 6.5e-230 637910005136 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005137 PS00104 EPSP synthase signature 1. 637910005138 PS00885 EPSP synthase signature 2. 637910005139 cytidylate kinase; Provisional; Region: cmk; PRK00023 637910005140 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 637910005141 CMP-binding site; other site 637910005142 The sites determining sugar specificity; other site 637910005143 HMMPfam hit to PF02224, Cytidylate kinase region, score 5.8e-93 637910005144 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 637910005145 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 637910005146 RNA binding site [nucleotide binding]; other site 637910005147 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 637910005148 RNA binding site [nucleotide binding]; other site 637910005149 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 637910005150 RNA binding site [nucleotide binding]; other site 637910005151 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 637910005152 RNA binding site [nucleotide binding]; other site 637910005153 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 637910005154 RNA binding site [nucleotide binding]; other site 637910005155 HMMPfam hit to PF00575, S1, RNA binding, score 1.5e-12 637910005156 HMMPfam hit to PF00575, S1, RNA binding, score 1.2e-17 637910005157 HMMPfam hit to PF00575, S1, RNA binding, score 7.1e-32 637910005158 HMMPfam hit to PF00575, S1, RNA binding, score 4.2e-30 637910005159 HMMPfam hit to PF00575, S1, RNA binding, score 5.8e-26 637910005160 HMMPfam hit to PF00575, S1, RNA binding, score 3.9e-25 637910005161 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 637910005162 IHF dimer interface [polypeptide binding]; other site 637910005163 IHF - DNA interface [nucleotide binding]; other site 637910005164 HMMPfam hit to PF00216, Histone-like bacterial DNA-binding protein, score 9.2e-47 637910005165 PS00045 Bacterial histone-like DNA-binding proteins signature. 637910005166 ComEC family competence protein; Provisional; Region: PRK11539 637910005167 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 637910005168 Competence protein; Region: Competence; pfam03772 637910005169 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 637910005170 10 transmembrane helices predicted for ROD09811 by TMHMM2.0 at aa 20-42, 49-71, 221-243, 264-286, 301-323, 328-346, 361-383, 390-412, 427-449 and 469-491 637910005171 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005172 HMMPfam hit to PF03772, ComEC/Rec2-related protein, score 1e-73 637910005173 HMMPfam hit to PF00753, beta-lactamase-like, score 3e-14 637910005174 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 637910005175 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637910005176 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 637910005177 Walker A/P-loop; other site 637910005178 ATP binding site [chemical binding]; other site 637910005179 Q-loop/lid; other site 637910005180 ABC transporter signature motif; other site 637910005181 Walker B; other site 637910005182 D-loop; other site 637910005183 H-loop/switch region; other site 637910005184 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 2.3e-67 637910005185 4 transmembrane helices predicted for ROD09821 by TMHMM2.0 at aa 27-49, 62-84, 164-186 and 245-267 637910005186 HMMPfam hit to PF00005, ABC transporter related, score 1e-64 637910005187 PS00017 ATP/GTP-binding site motif A (P-loop). 637910005188 PS00211 ABC transporters family signature. 637910005189 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 637910005190 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 637910005191 HMMPfam hit to PF02606, Tetraacyldisaccharide-1-P 4'-kinase, score 7.5e-175 637910005192 1 transmembrane helix predicted for ROD09831 by TMHMM2.0 at aa 12-34 637910005193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 637910005194 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 637910005195 HMMPfam hit to PF06224, Protein of unknown function DUF1006, score 4.6e-230 637910005196 hypothetical protein; Provisional; Region: PRK11827 637910005197 HMMPfam hit to PF03966, Protein of unknown function DUF343, score 1.9e-15 637910005198 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 637910005199 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 637910005200 Ligand binding site; other site 637910005201 oligomer interface; other site 637910005202 HMMPfam hit to PF02348, Acylneuraminate cytidylyltransferase, score 1.2e-97 637910005203 hypothetical protein; Provisional; Region: PRK10593 637910005204 Uncharacterized conserved protein [Function unknown]; Region: COG1434 637910005205 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 637910005206 putative active site [active] 637910005207 HMMPfam hit to PF02698, Protein of unknown function DUF218, score 5.6e-46 637910005208 2 transmembrane helices predicted for ROD09881 by TMHMM2.0 at aa 10-32 and 41-63 637910005209 Methyltransferase domain; Region: Methyltransf_31; pfam13847 637910005210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910005211 S-adenosylmethionine binding site [chemical binding]; other site 637910005212 HMMPfam hit to PF08241, Methyltransferase type 11, score 7.3e-19 637910005213 PS00017 ATP/GTP-binding site motif A (P-loop). 637910005214 condesin subunit F; Provisional; Region: PRK05260 637910005215 HMMPfam hit to PF03882, Prokaryotic chromosome segregation and condensation protein MukF, score 0 637910005216 condesin subunit E; Provisional; Region: PRK05256 637910005217 HMMPfam hit to PF04288, Prokaryotic chromosome segregation and condensation protein MukE, score 2.1e-164 637910005218 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 637910005219 P-loop containing region of AAA domain; Region: AAA_29; cl17516 637910005220 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 637910005221 HMMPfam hit to PF04310, Prokaryotic chromosome segregation and condensation protein MukB, N-terminal, score 5.2e-187 637910005222 PS00017 ATP/GTP-binding site motif A (P-loop). 637910005223 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 637910005224 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 637910005225 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 637910005226 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 637910005227 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 637910005228 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 637910005229 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 637910005230 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 637910005231 HMMPfam hit to PF02369, Bacterial Ig-like, group 1, score 1.6e-12 637910005232 HMMPfam hit to PF02369, Bacterial Ig-like, group 1, score 3.3e-11 637910005233 HMMPfam hit to PF02369, Bacterial Ig-like, group 1, score 4e-10 637910005234 HMMPfam hit to PF02369, Bacterial Ig-like, group 1, score 7.9e-18 637910005235 HMMPfam hit to PF02369, Bacterial Ig-like, group 1, score 8.6e-14 637910005236 HMMPfam hit to PF02369, Bacterial Ig-like, group 1, score 4.3e-09 637910005237 HMMPfam hit to PF02369, Bacterial Ig-like, group 1, score 1.9e-10 637910005238 murein L,D-transpeptidase; Provisional; Region: PRK10594 637910005239 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 637910005240 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637910005241 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637910005242 HMMPfam hit to PF01471, Peptidoglycan binding-like, score 8e-08 637910005243 PS00092 N-6 Adenine-specific DNA methylases signature. 637910005244 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 637910005245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 637910005246 Peptidase M15; Region: Peptidase_M15_3; cl01194 637910005247 1 transmembrane helix predicted for ROD09951 by TMHMM2.0 at aa 12-34 637910005248 HMMPfam hit to PF05951, Protein of unknown function DUF882, bacterial, score 1.5e-106 637910005249 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 637910005250 HMMPfam hit to PF00753, beta-lactamase-like, score 1.1e-38 637910005251 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 637910005252 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637910005253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910005254 homodimer interface [polypeptide binding]; other site 637910005255 catalytic residue [active] 637910005256 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 2.9e-142 637910005257 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 637910005258 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 637910005259 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 637910005260 trimer interface [polypeptide binding]; other site 637910005261 eyelet of channel; other site 637910005262 HMMPfam hit to PF00267, Porin, Gram-negative type, score 2e-189 637910005263 PS00576 General diffusion Gram-negative porins signature. 637910005264 1 transmembrane helix predicted for ROD09981 by TMHMM2.0 at aa 7-26 637910005265 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 637910005266 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 637910005267 putative dimer interface [polypeptide binding]; other site 637910005268 putative anticodon binding site; other site 637910005269 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 637910005270 homodimer interface [polypeptide binding]; other site 637910005271 motif 1; other site 637910005272 motif 2; other site 637910005273 active site 637910005274 motif 3; other site 637910005275 HMMPfam hit to PF00152, Aminoacyl-tRNA synthetase, class II (D, K and N), score 3.2e-77 637910005276 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910005277 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 637910005278 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 9.2e-19 637910005279 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 637910005280 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 637910005281 active site 637910005282 HMMPfam hit to PF04095, Nicotinate phosphoribosyltransferase-like, score 5.8e-123 637910005283 aminopeptidase N; Provisional; Region: pepN; PRK14015 637910005284 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 637910005285 active site 637910005286 Zn binding site [ion binding]; other site 637910005287 HMMPfam hit to PF01433, Peptidase M1, membrane alanine aminopeptidase, N-terminal, score 8.6e-70 637910005288 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 637910005289 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 637910005290 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 637910005291 Walker A/P-loop; other site 637910005292 ATP binding site [chemical binding]; other site 637910005293 Q-loop/lid; other site 637910005294 ABC transporter signature motif; other site 637910005295 Walker B; other site 637910005296 D-loop; other site 637910005297 H-loop/switch region; other site 637910005298 HMMPfam hit to PF00005, ABC transporter related, score 3.2e-56 637910005299 PS00211 ABC transporters family signature. 637910005300 PS00017 ATP/GTP-binding site motif A (P-loop). 637910005301 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 637910005302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910005303 dimer interface [polypeptide binding]; other site 637910005304 conserved gate region; other site 637910005305 putative PBP binding loops; other site 637910005306 ABC-ATPase subunit interface; other site 637910005307 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 6.4e-38 637910005308 7 transmembrane helices predicted for ROD10031 by TMHMM2.0 at aa 12-34, 64-86, 106-123, 128-147, 160-179, 189-211 and 223-245 637910005309 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 637910005310 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 637910005311 active site 637910005312 dimer interface [polypeptide binding]; other site 637910005313 non-prolyl cis peptide bond; other site 637910005314 insertion regions; other site 637910005315 HMMPfam hit to PF00296, Bacterial luciferase-like, score 0.00017 637910005316 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637910005317 substrate binding pocket [chemical binding]; other site 637910005318 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 637910005319 membrane-bound complex binding site; other site 637910005320 hinge residues; other site 637910005321 HMMPfam hit to PF09084, NMT1/THI5 like, score 3.5e-08 637910005322 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 637910005323 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637910005324 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 6e-55 637910005325 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 637910005326 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 637910005327 quinone interaction residues [chemical binding]; other site 637910005328 active site 637910005329 catalytic residues [active] 637910005330 FMN binding site [chemical binding]; other site 637910005331 substrate binding site [chemical binding]; other site 637910005332 HMMPfam hit to PF01180, Dihydroorotate dehydrogenase, core, score 5.4e-108 637910005333 PS00911 Dihydroorotate dehydrogenase signature 1. 637910005334 PS00912 Dihydroorotate dehydrogenase signature 2. 637910005335 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 637910005336 HMMPfam hit to PF07126, Protein of unknown function DUF1379, score 5.1e-122 637910005337 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 637910005338 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 637910005339 MOSC domain; Region: MOSC; pfam03473 637910005340 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637910005341 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 637910005342 catalytic loop [active] 637910005343 iron binding site [ion binding]; other site 637910005344 HMMPfam hit to PF00111, Ferredoxin, score 1.7e-17 637910005345 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 637910005346 HMMPfam hit to PF03473, Molybdenum cofactor sulphurase, C-terminal, score 4e-55 637910005347 HMMPfam hit to PF03476, MOSC, N-terminal beta barrel, score 1.1e-46 637910005348 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910005349 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 637910005350 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 637910005351 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 637910005352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910005353 S-adenosylmethionine binding site [chemical binding]; other site 637910005354 HMMPfam hit to PF02926, THUMP, score 4.5e-20 637910005355 HMMPfam hit to PF01170, RNA methylase, score 1.5e-98 637910005356 PS01261 Uncharacterized protein family UPF0020 signature. 637910005357 PS00092 N-6 Adenine-specific DNA methylases signature. 637910005358 HMMPfam hit to PF03602, Conserved hypothetical protein CHP00095, score 0.0043 637910005359 ABC transporter ATPase component; Reviewed; Region: PRK11147 637910005360 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910005361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910005362 Walker A/P-loop; other site 637910005363 Walker A/P-loop; other site 637910005364 ATP binding site [chemical binding]; other site 637910005365 ATP binding site [chemical binding]; other site 637910005366 Q-loop/lid; other site 637910005367 Q-loop/lid; other site 637910005368 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637910005369 ABC transporter signature motif; other site 637910005370 Walker B; other site 637910005371 D-loop; other site 637910005372 ABC transporter; Region: ABC_tran_2; pfam12848 637910005373 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637910005374 HMMPfam hit to PF00005, ABC transporter related, score 5.2e-48 637910005375 PS00017 ATP/GTP-binding site motif A (P-loop). 637910005376 PS00211 ABC transporters family signature. 637910005377 HMMPfam hit to PF00005, ABC transporter related, score 4.7e-47 637910005378 PS00017 ATP/GTP-binding site motif A (P-loop). 637910005379 PS00211 ABC transporters family signature. 637910005380 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 637910005381 Paraquat-inducible protein A; Region: PqiA; pfam04403 637910005382 Paraquat-inducible protein A; Region: PqiA; pfam04403 637910005383 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 1.6e-91 637910005384 8 transmembrane helices predicted for ROD10121 by TMHMM2.0 at aa 54-76, 100-122, 135-157, 162-184, 255-277, 304-326, 350-372 and 377-399 637910005385 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 6.1e-101 637910005386 paraquat-inducible protein B; Provisional; Region: PRK10807 637910005387 mce related protein; Region: MCE; pfam02470 637910005388 mce related protein; Region: MCE; pfam02470 637910005389 mce related protein; Region: MCE; pfam02470 637910005390 1 transmembrane helix predicted for ROD10131 by TMHMM2.0 at aa 16-38 637910005391 HMMPfam hit to PF02470, Mammalian cell entry related, score 7.5e-23 637910005392 HMMPfam hit to PF02470, Mammalian cell entry related, score 0.0024 637910005393 HMMPfam hit to PF02470, Mammalian cell entry related, score 2.2e-14 637910005394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 637910005395 Protein of unknown function (DUF330); Region: DUF330; pfam03886 637910005396 HMMPfam hit to PF03886, Protein of unknown function DUF330, score 5.9e-88 637910005397 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005398 ribosome modulation factor; Provisional; Region: PRK14563 637910005399 HMMPfam hit to PF04957, Ribosome modulation factor, score 5.1e-44 637910005400 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 637910005401 active site 1 [active] 637910005402 dimer interface [polypeptide binding]; other site 637910005403 active site 2 [active] 637910005404 HMMPfam hit to PF07977, beta-hydroxyacyl-ACP dehydratase, FabA/FabZ, score 4.9e-74 637910005405 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 637910005406 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 637910005407 HMMPfam hit to PF05362, Peptidase S16, lon C-terminal, score 0.00023 637910005408 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 637910005409 HMMPfam hit to PF06303, Protein of unknown function DUF1047, score 9.9e-89 637910005410 outer membrane protein A; Reviewed; Region: PRK10808 637910005411 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 637910005412 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637910005413 ligand binding site [chemical binding]; other site 637910005414 HMMPfam hit to PF00691, Outer membrane protein, OmpA/MotB, C-terminal, score 1.3e-47 637910005415 PS01068 OmpA-like domain. 637910005416 HMMPfam hit to PF01389, Outer membrane protein, OmpA-like, transmembrane region, score 1.6e-121 637910005417 SOS cell division inhibitor; Provisional; Region: PRK10595 637910005418 HMMPfam hit to PF03846, Cell division inhibitor SulA, score 3.5e-92 637910005419 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 637910005420 TfoX C-terminal domain; Region: TfoX_C; pfam04994 637910005421 HMMPfam hit to PF04993, TfoX, N-terminal, score 1.1e-07 637910005422 HMMPfam hit to PF04994, TfoX, C-terminal, score 2.1e-36 637910005423 TIGR01666 family membrane protein; Region: YCCS 637910005424 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 637910005425 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 637910005426 HMMPfam hit to PF05976, Protein of unknown function DUF893, YccS/YhfK, score 0 637910005427 11 transmembrane helices predicted for ROD10221 by TMHMM2.0 at aa 13-35, 40-54, 67-85, 89-108, 115-137, 141-163, 400-422, 437-459, 466-483, 488-510 and 517-534 637910005428 PS00217 Sugar transport proteins signature 2. 637910005429 Predicted membrane protein [Function unknown]; Region: COG3304 637910005430 Domain of unknown function (DUF307); Region: DUF307; pfam03733 637910005431 Domain of unknown function (DUF307); Region: DUF307; pfam03733 637910005432 HMMPfam hit to PF03733, Protein of unknown function DUF307, score 1.3e-31 637910005433 3 transmembrane helices predicted for ROD10231 by TMHMM2.0 at aa 32-54, 99-121 and 125-147 637910005434 HMMPfam hit to PF03733, Protein of unknown function DUF307, score 8.8e-20 637910005435 DNA helicase IV; Provisional; Region: helD; PRK11054 637910005436 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 637910005437 Part of AAA domain; Region: AAA_19; pfam13245 637910005438 Family description; Region: UvrD_C_2; pfam13538 637910005439 HMMPfam hit to PF00580, DNA helicase, UvrD/REP type, score 2.9e-21 637910005440 PS00017 ATP/GTP-binding site motif A (P-loop). 637910005441 HMMPfam hit to PF00580, DNA helicase, UvrD/REP type, score 1.1e-17 637910005442 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 637910005443 active site 637910005444 dimer interfaces [polypeptide binding]; other site 637910005445 catalytic residues [active] 637910005446 HMMPfam hit to PF02142, MGS-like, score 1.7e-27 637910005447 PS01335 Methylglyoxal synthase active site. 637910005448 hypothetical protein; Provisional; Region: PRK03641 637910005449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 637910005450 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 637910005451 HMMPfam hit to PF02629, CoA-binding, score 1.1e-25 637910005452 heat shock protein HspQ; Provisional; Region: PRK14129 637910005453 HMMPfam hit to PF08755, Hemimethylated DNA-binding region, score 6.1e-50 637910005454 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 637910005455 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 637910005456 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 637910005457 putative RNA binding site [nucleotide binding]; other site 637910005458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910005459 S-adenosylmethionine binding site [chemical binding]; other site 637910005460 PS00294 Prenyl group binding site (CAAX box). 637910005461 HMMPfam hit to PF03602, Conserved hypothetical protein CHP00095, score 0.0014 637910005462 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005463 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005464 acylphosphatase; Provisional; Region: PRK14426 637910005465 HMMPfam hit to PF00708, Acylphosphatase, score 8.3e-15 637910005466 PS00150 Acylphosphatase signature 1. 637910005467 PS00151 Acylphosphatase signature 2. 637910005468 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 637910005469 sulfur transfer protein TusE; Provisional; Region: PRK11508 637910005470 HMMPfam hit to PF04358, DsrC-like protein, score 6.1e-76 637910005471 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 637910005472 YccA-like proteins; Region: YccA_like; cd10433 637910005473 HMMPfam hit to PF01027, Protein of unknown function UPF0005, score 1.7e-59 637910005474 7 transmembrane helices predicted for ROD10321 by TMHMM2.0 at aa 21-40, 45-67, 74-96, 106-125, 132-154, 159-181 and 194-216 637910005475 PS01243 Uncharacterized protein family UPF0005 signature. 637910005476 prophage remnant; CRPr11 637910005477 pseudogene, fragmented by two frameshifts and N-terminal deleted by ISCro1 insertion 637910005478 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 0.0017 637910005479 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910005480 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910005481 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910005482 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910005483 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910005484 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910005485 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910005486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910005487 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910005488 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910005489 Transposase; Region: HTH_Tnp_1; pfam01527 637910005490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910005491 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910005492 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910005493 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 637910005494 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 637910005495 Acyltransferase family; Region: Acyl_transf_3; pfam01757 637910005496 HMMPfam hit to PF01757, Acyltransferase 3, score 0.00015 637910005497 10 transmembrane helices predicted for ROD10401 by TMHMM2.0 at aa 13-31, 46-65, 86-108, 118-140, 147-169, 179-196, 203-225, 240-262, 269-287 and 300-322 637910005498 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005499 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 637910005500 catalytic residues [active] 637910005501 HMMPfam hit to PF00959, Glycoside hydrolase, family 24, score 2.7e-27 637910005502 1 transmembrane helix predicted for ROD10412 by TMHMM2.0 at aa 7-25 637910005503 CR_GI3 637910005504 pseudogene, N-terminus missing, fragment; Similarity to prophage CP-933M is probably due to the same integration site in tRNAser 637910005505 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637910005506 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 637910005507 ligand binding site [chemical binding]; other site 637910005508 flexible hinge region; other site 637910005509 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 637910005510 HMMPfam hit to PF00027, Cyclic nucleotide-binding, score 1.7e-18 637910005511 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 637910005512 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 637910005513 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005514 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910005515 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 637910005516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 637910005517 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2.9e-14 637910005518 1 transmembrane helix predicted for ROD10491 by TMHMM2.0 at aa 20-37 637910005519 pseudogene, truncated by frameshift mutation 637910005520 HMMPfam hit to PF03212, Pertactin, score 1.1e-05 637910005521 HMMPfam hit to PF03797, Autotransporter beta-domain, score 8e-41 637910005522 pseudogene, C-terminus missing, fragment 637910005523 hypothetical protein; Provisional; Region: PRK12378 637910005524 HMMPfam hit to PF01709, Protein of unknown function DUF28, score 6.1e-126 637910005525 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 637910005526 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 637910005527 Cytochrome c; Region: Cytochrom_C; pfam00034 637910005528 HMMPfam hit to PF00034, Cytochrome c, class I, score 4.4e-05 637910005529 PS00190 Cytochrome c family heme-binding site signature. 637910005530 PS00190 Cytochrome c family heme-binding site signature. 637910005531 PS00190 Cytochrome c family heme-binding site signature. 637910005532 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 637910005533 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 637910005534 PS00318 Hydroxymethylglutaryl-coenzyme A reductases signature 2. 637910005535 HMMPfam hit to PF00732, Glucose-methanol-choline oxidoreductase, N-terminal, score 0.00044 637910005536 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 637910005537 Domain of unknown function DUF20; Region: UPF0118; pfam01594 637910005538 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 637910005539 8 transmembrane helices predicted for ROD10571 by TMHMM2.0 at aa 5-23, 27-46, 59-81, 154-176, 210-232, 247-269, 276-298 and 318-340 637910005540 HMMPfam hit to PF01594, Protein of unknown function UPF0118, score 6.3e-46 637910005541 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005542 4Fe-4S binding domain; Region: Fer4_5; pfam12801 637910005543 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 637910005544 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637910005545 5 transmembrane helices predicted for ROD10581 by TMHMM2.0 at aa 37-54, 92-114, 159-181, 196-218 and 312-334 637910005546 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.00072 637910005547 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910005548 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.00019 637910005549 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910005550 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 637910005551 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 637910005552 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 637910005553 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 637910005554 HSP70 interaction site [polypeptide binding]; other site 637910005555 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 637910005556 substrate binding site [polypeptide binding]; other site 637910005557 dimer interface [polypeptide binding]; other site 637910005558 HMMPfam hit to PF01556, chaperone DnaJ, C-terminal, score 1.1e-35 637910005559 HMMPfam hit to PF00226, Heat shock protein DnaJ, N-terminal, score 3.9e-34 637910005560 PS00636 Nt-dnaJ domain signature. 637910005561 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 637910005562 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 637910005563 catalytic core [active] 637910005564 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 637910005565 HMMPfam hit to PF00328, Histidine acid phosphatase, score 3.6e-55 637910005566 PS00616 Histidine acid phosphatases phosphohistidine signature. 637910005567 PS00778 Histidine acid phosphatases active site signature. 637910005568 hypothetical protein; Provisional; Region: PRK10174 637910005569 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 637910005570 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637910005571 HMMPfam hit to PF00258, Flavodoxin/nitric oxide synthase, score 5.1e-26 637910005572 General stress protein [General function prediction only]; Region: GsiB; COG3729 637910005573 PS00017 ATP/GTP-binding site motif A (P-loop). 637910005574 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 637910005575 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637910005576 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 637910005577 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 9.6e-17 637910005578 HMMPfam hit to PF08362, Transcriptional regulator, YcdC, C-terminal, score 3e-91 637910005579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 637910005580 HMMPfam hit to PF07007, Protein of unknown function DUF1311, score 1.1e-37 637910005581 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 637910005582 Predicted transcriptional regulator [Transcription]; Region: COG3905 637910005583 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 637910005584 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 637910005585 Glutamate binding site [chemical binding]; other site 637910005586 NAD binding site [chemical binding]; other site 637910005587 catalytic residues [active] 637910005588 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 637910005589 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 2e-105 637910005590 PS00070 Aldehyde dehydrogenases cysteine active site. 637910005591 PS00687 Aldehyde dehydrogenases glutamic acid active site. 637910005592 HMMPfam hit to PF01619, Proline dehydrogenase, score 1.3e-191 637910005593 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005594 1 transmembrane helix predicted for ROD10691 by TMHMM2.0 at aa 24-46 637910005595 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 637910005596 Na binding site [ion binding]; other site 637910005597 12 transmembrane helices predicted for ROD10701 by TMHMM2.0 at aa 7-26, 66-88, 125-147, 162-184, 191-213, 233-255, 276-298, 313-335, 372-391, 401-423, 428-450 and 455-473 637910005598 HMMPfam hit to PF00474, Na+/solute symporter, score 6e-217 637910005599 PS00456 Sodium:solute symporter family signature 1. 637910005600 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005601 Iron permease FTR1 family; Region: FTR1; cl00475 637910005602 HMMPfam hit to PF03239, Iron permease FTR1, score 9.4e-68 637910005603 6 transmembrane helices predicted for ROD10711 by TMHMM2.0 at aa 2-24, 34-53, 81-103, 113-135, 142-164 and 212-229 637910005604 PS00435 Peroxidases proximal heme-ligand signature. 637910005605 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 637910005606 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 637910005607 Imelysin; Region: Peptidase_M75; pfam09375 637910005608 HMMPfam hit to PF04302, Protein of unknown function DUF451, score 8.7e-172 637910005609 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 637910005610 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 637910005611 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005612 HMMPfam hit to PF04261, Dyp-type peroxidase, score 1.7e-183 637910005613 pseudogene, truncated by frameshift mutation; N-terminus is frameshifted compared to the E. coli homologue, which has been overexpressed and N-terminal aa sequenced. The C. rodentium frameshifted N-terminus is absent from homologues in other enterics including Salonella, Yersinia and Erwinia. 637910005614 HMMPfam hit to PF02562, PhoH-like protein, score 5.1e-138 637910005615 CR_GI4 637910005616 pseudogene, C-terminus missing, fragment 637910005617 pseudogene, N- and C-termini missing, fragment 637910005618 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 637910005619 HMMPfam hit to PF07906, ShET2 enterotoxin, N-terminal, score 7.2e-123 637910005620 pseudogene, fragmented by multiple mutations. Lacking start codon due to missense mutation at N-terminus, also truncated by frameshift mutation and premature stop codon 637910005621 HMMPfam hit to PF01797, Transposase IS200-like, score 2.1e-62 637910005622 pseudogene, N-terminal 165aa of ISCro3 transposase, fragment. C-terminal region is found downstream of adjacent IS element fragment 637910005623 pseudogene, N-terminal 40 aa missing, fragment 637910005624 HMMPfam hit to PF01797, Transposase IS200-like, score 7.7e-39 637910005625 pseudogene, N- and C-termini missing, fragment. aa 283 to 422 of ISCro3 transposase. Terminal 23 aa of the transposase are missing, part of N-terminus is upstream of adjacent IS200-family IS element fragment 637910005626 HMMPfam hit to PF01609, Transposase, IS4-like, score 2.1e-14 637910005627 type III secretion system protein; Provisional; Region: PRK15384; cl14665 637910005628 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 637910005629 pseudogene, truncated by frameshift mutation and premature stop codon 637910005630 HMMPfam hit to PF01695, IstB-like ATP-binding protein, score 5.1e-54 637910005631 HMMPfam hit to PF08483, IstB-like ATP binding N-terminal, score 1.3e-10 637910005632 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 637910005633 HMMPfam hit to PF06117, Protein of unknown function DUF957, enterobacteria, score 5.4e-44 637910005634 pseudogene, truncated by two frameshift mutations 637910005635 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 637910005636 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 637910005637 putative ligand binding site [chemical binding]; other site 637910005638 NAD binding site [chemical binding]; other site 637910005639 dimerization interface [polypeptide binding]; other site 637910005640 catalytic site [active] 637910005641 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, score 2e-49 637910005642 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 637910005643 putative hydrolase; Validated; Region: PRK09248 637910005644 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 637910005645 active site 637910005646 HMMPfam hit to PF02811, PHP, C-terminal, score 1.4e-42 637910005647 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 637910005648 HMMPfam hit to PF06192, Cytoplasmic chaperone TorD, score 1.1e-46 637910005649 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 637910005650 HMMPfam hit to PF06496, Protein of unknown function DUF1097, score 7.9e-91 637910005651 6 transmembrane helices predicted for ROD10941 by TMHMM2.0 at aa 20-37, 41-58, 65-84, 88-110, 115-134 and 139-161 637910005652 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005653 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005654 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 637910005655 HMMPfam hit to PF03783, Curli production assembly/transport component CsgG, score 1.6e-123 637910005656 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005657 curli assembly protein CsgF; Provisional; Region: PRK10050 637910005658 curli assembly protein CsgE; Provisional; Region: PRK10386 637910005659 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 637910005660 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 637910005661 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910005662 DNA binding residues [nucleotide binding] 637910005663 dimerization interface [polypeptide binding]; other site 637910005664 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 2.4e-21 637910005665 PS00622 Bacterial regulatory proteins, luxR family signature. 637910005666 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 637910005667 Curlin associated repeat; Region: Curlin_rpt; pfam07012 637910005668 Curlin associated repeat; Region: Curlin_rpt; pfam07012 637910005669 HMMPfam hit to PF07012, Curlin associated, score 1.8e-10 637910005670 HMMPfam hit to PF07012, Curlin associated, score 6.9e-09 637910005671 major curlin subunit; Provisional; Region: csgA; PRK10051 637910005672 Curlin associated repeat; Region: Curlin_rpt; pfam07012 637910005673 Curlin associated repeat; Region: Curlin_rpt; pfam07012 637910005674 HMMPfam hit to PF07012, Curlin associated, score 2e-07 637910005675 HMMPfam hit to PF07012, Curlin associated, score 6.1e-14 637910005676 HMMPfam hit to PF07012, Curlin associated, score 0.012 637910005677 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 637910005678 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637910005679 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 637910005680 putative ADP-ribose binding site [chemical binding]; other site 637910005681 putative active site [active] 637910005682 HMMPfam hit to PF01661, Appr-1-p processing, score 5.9e-68 637910005683 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 637910005684 PLD-like domain; Region: PLDc_2; pfam13091 637910005685 putative active site [active] 637910005686 catalytic site [active] 637910005687 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 637910005688 PLD-like domain; Region: PLDc_2; pfam13091 637910005689 putative active site [active] 637910005690 catalytic site [active] 637910005691 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 0.12 637910005692 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 0.033 637910005693 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 637910005694 Acyltransferase family; Region: Acyl_transf_3; pfam01757 637910005695 HMMPfam hit to PF01757, Acyltransferase 3, score 9.7e-43 637910005696 10 transmembrane helices predicted for ROD11061 by TMHMM2.0 at aa 17-39, 54-76, 88-110, 137-159, 172-194, 214-233, 240-262, 277-296, 309-331 and 335-357 637910005697 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 637910005698 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 637910005699 HMMPfam hit to PF04349, Glucan biosynthesis, periplasmic, MdoG C-terminal, score 0 637910005700 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 637910005701 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 637910005702 Ligand binding site; other site 637910005703 DXD motif; other site 637910005704 6 transmembrane helices predicted for ROD11091 by TMHMM2.0 at aa 139-156, 188-210, 512-534, 568-590, 603-625 and 680-702 637910005705 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 1.1e-13 637910005706 Predicted helix-turn-helix motif with score 1091.000, SD 2.90 at aa 806-827, sequence VTMARLHYRVWHSPERYSSWVN 637910005707 lipoprotein; Provisional; Region: PRK10175 637910005708 HMMPfam hit to PF07119, Protein of unknown function DUF1375, score 4.2e-36 637910005709 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005710 secY/secA suppressor protein; Provisional; Region: PRK11467 637910005711 drug efflux system protein MdtG; Provisional; Region: PRK09874 637910005712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910005713 putative substrate translocation pore; other site 637910005714 10 transmembrane helices predicted for ROD11121 by TMHMM2.0 at aa 36-58, 73-95, 108-130, 160-182, 189-211, 242-264, 271-293, 308-326, 333-355 and 392-414 637910005715 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.1e-51 637910005716 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 637910005717 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 637910005718 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 637910005719 putative acyl-acceptor binding pocket; other site 637910005720 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltransferase, score 7.8e-160 637910005721 1 transmembrane helix predicted for ROD11131 by TMHMM2.0 at aa 16-38 637910005722 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 637910005723 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 637910005724 active site residue [active] 637910005725 PS00017 ATP/GTP-binding site motif A (P-loop). 637910005726 HMMPfam hit to PF00581, Rhodanese-like, score 5e-29 637910005727 hypothetical protein; Provisional; Region: PRK03757 637910005728 HMMPfam hit to PF04264, Lipid/polyisoprenoid-binding, YceI-like, score 9.1e-86 637910005729 PS00387 Inorganic pyrophosphatase signature. 637910005730 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 637910005731 HMMPfam hit to PF01292, Cytochrome B561, bacterial, score 1.9e-70 637910005732 4 transmembrane helices predicted for ROD11161 by TMHMM2.0 at aa 13-35, 55-72, 92-114 and 147-169 637910005733 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 637910005734 1 transmembrane helix predicted for ROD11171 by TMHMM2.0 at aa 17-36 637910005735 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 637910005736 hydroxyglutarate oxidase; Provisional; Region: PRK11728 637910005737 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 8.2e-57 637910005738 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 637910005739 DNA damage-inducible protein I; Provisional; Region: PRK10597 637910005740 HMMPfam hit to PF06183, DinI-like, score 5.6e-36 637910005741 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 637910005742 active site 637910005743 substrate binding pocket [chemical binding]; other site 637910005744 dimer interface [polypeptide binding]; other site 637910005745 HMMPfam hit to PF01979, Amidohydrolase 1, score 6.4e-33 637910005746 PS00483 Dihydroorotase signature 2. 637910005747 PS00482 Dihydroorotase signature 1. 637910005748 lipoprotein; Provisional; Region: PRK10598 637910005749 HMMPfam hit to PF07273, Protein of unknown function DUF1439, score 2.7e-126 637910005750 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005751 glutaredoxin 2; Provisional; Region: PRK10387 637910005752 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 637910005753 C-terminal domain interface [polypeptide binding]; other site 637910005754 GSH binding site (G-site) [chemical binding]; other site 637910005755 catalytic residues [active] 637910005756 putative dimer interface [polypeptide binding]; other site 637910005757 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 637910005758 N-terminal domain interface [polypeptide binding]; other site 637910005759 HMMPfam hit to PF04399, Glutaredoxin 2, C-terminal, score 1.9e-79 637910005760 HMMPfam hit to PF00462, Glutaredoxin, score 1.2e-05 637910005761 PS00195 Glutaredoxin active site. 637910005762 pseudogene, truncated by frameshift mutation 637910005763 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 4.3e-45 637910005764 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 637910005765 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637910005766 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2.5e-12 637910005767 hypothetical protein; Provisional; Region: PRK11239 637910005768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 637910005769 HMMPfam hit to PF04337, Protein of unknown function DUF480, score 1.5e-131 637910005770 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005771 pseudogene, truncated by frameshift mutation 637910005772 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 1.4e-36 637910005773 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 637910005774 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 637910005775 13 transmembrane helices predicted for ROD11321 by TMHMM2.0 at aa 26-45, 88-110, 130-152, 159-181, 186-203, 237-259, 274-296, 316-338, 353-375, 382-404, 408-427, 444-466 and 481-503 637910005776 HMMPfam hit to PF03023, Virulence factor MVIN-like, score 2e-216 637910005777 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005778 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637910005779 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637910005780 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637910005781 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.2e-27 637910005782 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 1.2e-17 637910005783 HMMPfam hit to PF05130, FlgN, score 1.1e-56 637910005784 pseudogene, disrupted by ISCro3 insertion 637910005785 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 637910005786 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910005787 HMMPfam hit to PF01609, Transposase, IS4-like, score 3.6e-29 637910005788 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 637910005789 HMMPfam hit to PF04316, Anti-sigma-28 factor, FlgM, score 6.4e-27 637910005790 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 637910005791 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 637910005792 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 637910005793 HMMPfam hit to PF08666, SAF domain, score 7.6e-14 637910005794 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 637910005795 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 637910005796 HMMPfam hit to PF00460, Flagellar basal body rod protein, score 2.2e-12 637910005797 PS00588 Flagella basal body rod proteins signature. 637910005798 pseudogene, C-terminus missing, truncated by downstream deletion 637910005799 HMMPfam hit to PF00460, Flagellar basal body rod protein, score 1.9e-11 637910005800 pseudogene, N-terminus missing, truncated by upstream deletion 637910005801 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase, score 2.6e-09 637910005802 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 637910005803 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 637910005804 HMMPfam hit to PF00460, Flagellar basal body rod protein, score 5.9e-05 637910005805 HMMPfam hit to PF06429, Protein of unknown function DUF1078, C-terminal, score 1.6e-15 637910005806 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 637910005807 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 637910005808 HMMPfam hit to PF00669, Flagellin, N-terminal, score 1.5e-40 637910005809 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 637910005810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910005811 putative substrate translocation pore; other site 637910005812 12 transmembrane helices predicted for ROD11441 by TMHMM2.0 at aa 20-42, 57-79, 86-108, 113-135, 142-164, 169-191, 225-247, 257-279, 291-310, 314-333, 353-375 and 380-399 637910005813 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 8e-40 637910005814 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005815 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910005816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910005817 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 637910005818 putative effector binding pocket; other site 637910005819 dimerization interface [polypeptide binding]; other site 637910005820 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 5.9e-22 637910005821 Predicted helix-turn-helix motif with score 2061.000, SD 6.21 at aa 28-49, sequence GSLSAAARQLNTTQATISRRLQ 637910005822 PS00044 Bacterial regulatory proteins, lysR family signature. 637910005823 HMMPfam hit to PF03466, LysR, substrate-binding, score 4e-40 637910005824 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 637910005825 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 637910005826 homodimer interface [polypeptide binding]; other site 637910005827 oligonucleotide binding site [chemical binding]; other site 637910005828 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 637910005829 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005830 HMMPfam hit to PF00575, S1, RNA binding, score 6.1e-19 637910005831 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 637910005832 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637910005833 RNA binding surface [nucleotide binding]; other site 637910005834 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 637910005835 active site 637910005836 HMMPfam hit to PF01479, RNA-binding S4, score 2.6e-11 637910005837 HMMPfam hit to PF00849, Pseudouridine synthase, score 2.6e-60 637910005838 PS01129 Rlu family of pseudouridine synthase signature. 637910005839 Maf-like protein; Region: Maf; pfam02545 637910005840 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 637910005841 active site 637910005842 dimer interface [polypeptide binding]; other site 637910005843 HMMPfam hit to PF02545, Maf-like protein, score 2.1e-83 637910005844 hypothetical protein; Provisional; Region: PRK11193 637910005845 HMMPfam hit to PF02620, Protein of unknown function DUF177, score 3.7e-55 637910005846 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 637910005847 HMMPfam hit to PF01783, Ribosomal protein L32p, score 2.3e-20 637910005848 putative phosphate acyltransferase; Provisional; Region: PRK05331 637910005849 HMMPfam hit to PF02504, Fatty acid synthesis plsX protein, score 1.6e-185 637910005850 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 637910005851 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 637910005852 dimer interface [polypeptide binding]; other site 637910005853 active site 637910005854 CoA binding pocket [chemical binding]; other site 637910005855 HMMPfam hit to PF08545, 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, score 7.9e-43 637910005856 HMMPfam hit to PF08541, 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal, score 7.6e-54 637910005857 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 637910005858 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 637910005859 HMMPfam hit to PF00698, Acyl transferase, score 1.6e-23 637910005860 PS00435 Peroxidases proximal heme-ligand signature. 637910005861 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 637910005862 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 637910005863 NAD(P) binding site [chemical binding]; other site 637910005864 homotetramer interface [polypeptide binding]; other site 637910005865 homodimer interface [polypeptide binding]; other site 637910005866 active site 637910005867 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 6.2e-43 637910005868 PS00061 Short-chain dehydrogenases/reductases family signature. 637910005869 acyl carrier protein; Provisional; Region: acpP; PRK00982 637910005870 HMMPfam hit to PF00550, Phosphopantetheine-binding, score 4.3e-24 637910005871 PS00012 Phosphopantetheine attachment site. 637910005872 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 637910005873 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 637910005874 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 637910005875 dimer interface [polypeptide binding]; other site 637910005876 active site 637910005877 HMMPfam hit to PF00109, beta-ketoacyl synthase, N-terminal, score 1.6e-75 637910005878 PS00606 beta-ketoacyl synthases active site. 637910005879 HMMPfam hit to PF02801, beta-ketoacyl synthase, C-terminal, score 4.6e-57 637910005880 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 637910005881 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 637910005882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910005883 catalytic residue [active] 637910005884 HMMPfam hit to PF01063, Aminotransferase, class IV, score 4.8e-57 637910005885 PS00770 Aminotransferases class-IV signature. 637910005886 conserved hypothetical protein, YceG family; Region: TIGR00247 637910005887 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 637910005888 dimerization interface [polypeptide binding]; other site 637910005889 1 transmembrane helix predicted for ROD11591 by TMHMM2.0 at aa 5-24 637910005890 HMMPfam hit to PF02618, Aminodeoxychorismate lyase, score 2e-151 637910005891 thymidylate kinase; Validated; Region: tmk; PRK00698 637910005892 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 637910005893 TMP-binding site; other site 637910005894 ATP-binding site [chemical binding]; other site 637910005895 HMMPfam hit to PF02223, thymidylate kinase, score 2.2e-82 637910005896 PS00017 ATP/GTP-binding site motif A (P-loop). 637910005897 PS01331 thymidylate kinase signature. 637910005898 DNA polymerase III subunit delta'; Validated; Region: PRK07993 637910005899 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 637910005900 HMMPfam hit to PF09115, DNA polymerase III subunit delta, C-terminal, score 3.3e-42 637910005901 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 637910005902 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 637910005903 active site 637910005904 HMMPfam hit to PF01026, Deoxyribonuclease, TatD-related, score 2.1e-117 637910005905 PS01137 Uncharacterized protein family UPF0006 signature 1. 637910005906 PS01091 Uncharacterized protein family UPF0006 signature 3. 637910005907 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 637910005908 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 637910005909 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637910005910 active site turn [active] 637910005911 phosphorylation site [posttranslational modification] 637910005912 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.2e-108 637910005913 10 transmembrane helices predicted for ROD11631 by TMHMM2.0 at aa 21-43, 53-72, 79-101, 116-135, 155-177, 192-214, 250-272, 282-304, 309-331 and 354-376 637910005914 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 2.7e-18 637910005915 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 637910005916 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 637910005917 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637910005918 N-terminal plug; other site 637910005919 ligand-binding site [chemical binding]; other site 637910005920 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 2.4e-27 637910005921 PS01156 TonB-dependent receptor proteins signature 2. 637910005922 HMMPfam hit to PF07715, TonB-dependent receptor, plug, score 1.1e-18 637910005923 PS00430 TonB-dependent receptor proteins signature 1. 637910005924 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 637910005925 nucleotide binding site/active site [active] 637910005926 HIT family signature motif; other site 637910005927 catalytic residue [active] 637910005928 HMMPfam hit to PF01230, Histidine triad (HIT) protein, score 2.9e-47 637910005929 PS00892 HIT family signature. 637910005930 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 637910005931 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 637910005932 putative dimer interface [polypeptide binding]; other site 637910005933 HMMPfam hit to PF07233, Protein of unknown function DUF1425, score 3e-62 637910005934 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005935 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 637910005936 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910005937 thiamine kinase; Region: ycfN_thiK; TIGR02721 637910005938 active site 637910005939 substrate binding site [chemical binding]; other site 637910005940 ATP binding site [chemical binding]; other site 637910005941 thiamine kinase; Provisional; Region: thiK; PRK10271 637910005942 HMMPfam hit to PF01636, Aminoglycoside phosphotransferase, score 2.1e-24 637910005943 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 637910005944 beta-hexosaminidase; Provisional; Region: PRK05337 637910005945 HMMPfam hit to PF00933, Glycoside hydrolase, family 3, N-terminal, score 4.5e-86 637910005946 PS00775 Glycosyl hydrolases family 3 active site. 637910005947 hypothetical protein; Provisional; Region: PRK04940 637910005948 HMMPfam hit to PF05728, Protein of unknown function UPF0227, score 5.3e-106 637910005949 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 637910005950 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637910005951 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 5.9e-34 637910005952 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 2.8e-24 637910005953 hypothetical protein; Provisional; Region: PRK11280 637910005954 1 transmembrane helix predicted for ROD11731 by TMHMM2.0 at aa 5-27 637910005955 HMMPfam hit to PF05433, Rickettsia 17 kDa surface antigen, score 1.3e-14 637910005956 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 2.1e-09 637910005957 pseudogene, N-terminus missing, fragment 637910005958 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637910005959 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637910005960 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 1e-15 637910005961 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 637910005962 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 2.4e-23 637910005963 putative fimbrial chaperone protein; Provisional; Region: PRK09918 637910005964 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637910005965 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637910005966 1 transmembrane helix predicted for ROD11771 by TMHMM2.0 at aa 7-29 637910005967 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 6e-25 637910005968 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 1.3e-07 637910005969 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 637910005970 PapC N-terminal domain; Region: PapC_N; pfam13954 637910005971 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637910005972 PapC C-terminal domain; Region: PapC_C; pfam13953 637910005973 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 8.1e-94 637910005974 PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 637910005975 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 637910005976 hypothetical protein; Provisional; Region: PRK15301 637910005977 L,D-transpeptidase; Provisional; Region: PRK10190 637910005978 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637910005979 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637910005980 HMMPfam hit to PF03734, ErfK/YbiS/YcfS/YnhG, score 2.7e-65 637910005981 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 4.8e-08 637910005982 transcription-repair coupling factor; Provisional; Region: PRK10689 637910005983 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 637910005984 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637910005985 ATP binding site [chemical binding]; other site 637910005986 putative Mg++ binding site [ion binding]; other site 637910005987 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637910005988 nucleotide binding region [chemical binding]; other site 637910005989 ATP-binding site [chemical binding]; other site 637910005990 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 637910005991 HMMPfam hit to PF03461, TRCF, score 3.6e-55 637910005992 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 1.6e-21 637910005993 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 5e-44 637910005994 PS00017 ATP/GTP-binding site motif A (P-loop). 637910005995 HMMPfam hit to PF02559, Transcription factor CarD, score 7.6e-50 637910005996 Predicted membrane protein [Function unknown]; Region: COG4763 637910005997 Acyltransferase family; Region: Acyl_transf_3; pfam01757 637910005998 HMMPfam hit to PF01757, Acyltransferase 3, score 1.3e-46 637910005999 8 transmembrane helices predicted for ROD11821 by TMHMM2.0 at aa 13-32, 47-69, 90-112, 132-154, 166-188, 229-251, 272-294 and 309-331 637910006000 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 637910006001 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637910006002 FtsX-like permease family; Region: FtsX; pfam02687 637910006003 4 transmembrane helices predicted for ROD11831 by TMHMM2.0 at aa 25-47, 266-288, 318-340 and 360-382 637910006004 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 4.1e-47 637910006005 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 637910006006 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637910006007 Walker A/P-loop; other site 637910006008 ATP binding site [chemical binding]; other site 637910006009 Q-loop/lid; other site 637910006010 ABC transporter signature motif; other site 637910006011 Walker B; other site 637910006012 D-loop; other site 637910006013 H-loop/switch region; other site 637910006014 HMMPfam hit to PF00005, ABC transporter related, score 1e-65 637910006015 PS00017 ATP/GTP-binding site motif A (P-loop). 637910006016 PS00211 ABC transporters family signature. 637910006017 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 637910006018 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637910006019 FtsX-like permease family; Region: FtsX; pfam02687 637910006020 4 transmembrane helices predicted for ROD11851 by TMHMM2.0 at aa 21-43, 270-292, 318-340 and 375-397 637910006021 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 1.3e-51 637910006022 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006023 PS00027 'Homeobox' domain signature. 637910006024 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637910006025 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637910006026 nucleotide binding site [chemical binding]; other site 637910006027 HMMPfam hit to PF00480, ROK, score 2.4e-53 637910006028 PS01125 ROK family signature. 637910006029 PS00017 ATP/GTP-binding site motif A (P-loop). 637910006030 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 637910006031 NAD-dependent deacetylase; Provisional; Region: PRK00481 637910006032 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 637910006033 NAD+ binding site [chemical binding]; other site 637910006034 substrate binding site [chemical binding]; other site 637910006035 Zn binding site [ion binding]; other site 637910006036 HMMPfam hit to PF02146, Silent information regulator protein Sir2, score 1.5e-86 637910006037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910006038 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637910006039 putative substrate translocation pore; other site 637910006040 9 transmembrane helices predicted for ROD11881 by TMHMM2.0 at aa 13-35, 50-72, 85-107, 172-194, 215-232, 247-269, 289-311, 341-363 and 368-390 637910006041 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 2.1e-39 637910006042 tRNA-guanine transglycosylase, archaeosine-15-forming; Region: arcsn_tRNA_tgt; TIGR00432 637910006043 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006044 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 637910006045 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637910006046 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637910006047 HMMPfam hit to PF03797, Autotransporter beta-domain, score 5.3e-33 637910006048 HMMPfam hit to PF03212, Pertactin, score 1.2e-43 637910006049 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 637910006050 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 637910006051 MOFRL family; Region: MOFRL; pfam05161 637910006052 HMMPfam hit to PF05161, MOFRL, score 3.1e-52 637910006053 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 637910006054 tartrate dehydrogenase; Region: TTC; TIGR02089 637910006055 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 4.1e-97 637910006056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910006057 putative substrate translocation pore; other site 637910006058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 637910006059 9 transmembrane helices predicted for ROD11941 by TMHMM2.0 at aa 13-35, 50-69, 82-104, 114-136, 143-165, 175-197, 244-266, 276-298 and 310-332 637910006060 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 6.5e-41 637910006061 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910006062 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006063 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 637910006064 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910006065 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 637910006066 dimerization interface [polypeptide binding]; other site 637910006067 substrate binding pocket [chemical binding]; other site 637910006068 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2.3e-12 637910006069 Predicted helix-turn-helix motif with score 1238.000, SD 3.40 at aa 16-37, sequence LHFGRAARKLEMMPASLSRFIK 637910006070 HMMPfam hit to PF03466, LysR, substrate-binding, score 1e-40 637910006071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637910006072 Coenzyme A binding pocket [chemical binding]; other site 637910006073 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.1e-15 637910006074 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 637910006075 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637910006076 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637910006077 HMMPfam hit to PF03797, Autotransporter beta-domain, score 1.4e-31 637910006078 HMMPfam hit to PF03212, Pertactin, score 1.5e-44 637910006079 1 transmembrane helix predicted for ROD11971 by TMHMM2.0 at aa 13-35 637910006080 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637910006081 catalytic residues [active] 637910006082 HMMPfam hit to PF00085, Thioredoxin domain, score 0.00014 637910006083 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 637910006084 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 637910006085 Walker A/P-loop; other site 637910006086 ATP binding site [chemical binding]; other site 637910006087 Q-loop/lid; other site 637910006088 ABC transporter signature motif; other site 637910006089 Walker B; other site 637910006090 D-loop; other site 637910006091 H-loop/switch region; other site 637910006092 HMMPfam hit to PF00005, ABC transporter related, score 2.6e-65 637910006093 PS00211 ABC transporters family signature. 637910006094 PS00017 ATP/GTP-binding site motif A (P-loop). 637910006095 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 637910006096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910006097 dimer interface [polypeptide binding]; other site 637910006098 conserved gate region; other site 637910006099 putative PBP binding loops; other site 637910006100 ABC-ATPase subunit interface; other site 637910006101 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 637910006102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910006103 dimer interface [polypeptide binding]; other site 637910006104 conserved gate region; other site 637910006105 putative PBP binding loops; other site 637910006106 ABC-ATPase subunit interface; other site 637910006107 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.6e-23 637910006108 10 transmembrane helices predicted for ROD12001 by TMHMM2.0 at aa 20-37, 78-100, 107-129, 199-221, 228-250, 330-352, 364-383, 388-407, 435-457 and 485-502 637910006109 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3.2e-19 637910006110 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 637910006111 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 637910006112 membrane-bound complex binding site; other site 637910006113 HMMPfam hit to PF09084, NMT1/THI5 like, score 1.4e-09 637910006114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910006115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910006116 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637910006117 dimerization interface [polypeptide binding]; other site 637910006118 HMMPfam hit to PF03466, LysR, substrate-binding, score 3.4e-28 637910006119 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 637910006120 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 3e-19 637910006121 PS00044 Bacterial regulatory proteins, lysR family signature. 637910006122 Predicted helix-turn-helix motif with score 1482.000, SD 4.23 at aa 18-39, sequence GSFNRAAEAVCLSQSAFSRSIQ 637910006123 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 637910006124 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 637910006125 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 1.4e-11 637910006126 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 637910006127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910006128 dimer interface [polypeptide binding]; other site 637910006129 conserved gate region; other site 637910006130 putative PBP binding loops; other site 637910006131 ABC-ATPase subunit interface; other site 637910006132 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.4e-14 637910006133 6 transmembrane helices predicted for ROD12041 by TMHMM2.0 at aa 5-27, 64-86, 99-121, 126-148, 176-195 and 230-252 637910006134 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910006135 lambdoid prophage remnant; CRPr13 637910006136 pseudogene, truncated by frameshift mutation 637910006137 HMMPfam hit to PF08400, Prophage tail fibre N-terminal, score 4e-93 637910006138 HMMPfam hit to PF01391, Collagen triple helix repeat, score 4.5e-12 637910006139 HMMPfam hit to PF01391, Collagen triple helix repeat, score 5.5e-11 637910006140 HMMPfam hit to PF06820, prophage tail fibre, C-terminal, score 1.3e-45 637910006141 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 637910006142 HMMPfam hit to PF06820, prophage tail fibre, C-terminal, score 6.8e-41 637910006143 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 637910006144 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 637910006145 SopA-like central domain; Region: SopA; pfam13981 637910006146 SopA-like catalytic domain; Region: SopA_C; pfam13979 637910006147 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006148 HMMPfam hit to PF00805, Pentapeptide repeat, score 7.7e-06 637910006149 HMMPfam hit to PF00805, Pentapeptide repeat, score 0.00026 637910006150 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 637910006151 pseudogene, fragmented by two frameshift mutations and a premature stop codon 637910006152 type III secretion protein GogB; Provisional; Region: PRK15386 637910006153 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006154 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 637910006155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910006156 dimer interface [polypeptide binding]; other site 637910006157 conserved gate region; other site 637910006158 putative PBP binding loops; other site 637910006159 ABC-ATPase subunit interface; other site 637910006160 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.8e-14 637910006161 6 transmembrane helices predicted for ROD12131 by TMHMM2.0 at aa 5-27, 59-81, 88-110, 141-163, 184-206 and 240-262 637910006162 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006163 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910006164 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006165 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 637910006166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910006167 Walker A/P-loop; other site 637910006168 ATP binding site [chemical binding]; other site 637910006169 Q-loop/lid; other site 637910006170 ABC transporter signature motif; other site 637910006171 Walker B; other site 637910006172 D-loop; other site 637910006173 H-loop/switch region; other site 637910006174 TOBE domain; Region: TOBE_2; pfam08402 637910006175 HMMPfam hit to PF08402, Transport-associated OB, type 2, score 3.3e-07 637910006176 HMMPfam hit to PF00005, ABC transporter related, score 3.3e-66 637910006177 PS00211 ABC transporters family signature. 637910006178 PS00017 ATP/GTP-binding site motif A (P-loop). 637910006179 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 637910006180 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 637910006181 metal binding site [ion binding]; metal-binding site 637910006182 dimer interface [polypeptide binding]; other site 637910006183 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 637910006184 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 637910006185 HMMPfam hit to PF01546, Peptidase M20, score 2.9e-17 637910006186 HMMPfam hit to PF07687, Peptidase M20, dimerisation, score 1.6e-26 637910006187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637910006188 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637910006189 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637910006190 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 1.2e-17 637910006191 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.2e-27 637910006192 Uncharacterized conserved protein [Function unknown]; Region: COG2850 637910006193 Cupin domain; Region: Cupin_2; cl17218 637910006194 HMMPfam hit to PF08007, Cupin 4, score 3e-154 637910006195 sensor protein PhoQ; Provisional; Region: PRK10815 637910006196 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 637910006197 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 637910006198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910006199 ATP binding site [chemical binding]; other site 637910006200 Mg2+ binding site [ion binding]; other site 637910006201 G-X-G motif; other site 637910006202 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 3.9e-30 637910006203 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 0.00042 637910006204 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 2.6e-08 637910006205 2 transmembrane helices predicted for ROD12181 by TMHMM2.0 at aa 20-42 and 194-216 637910006206 HMMPfam hit to PF08918, PhoQ Sensor, score 3.2e-122 637910006207 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 637910006208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910006209 active site 637910006210 phosphorylation site [posttranslational modification] 637910006211 intermolecular recognition site; other site 637910006212 dimerization interface [polypeptide binding]; other site 637910006213 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637910006214 DNA binding site [nucleotide binding] 637910006215 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 8.7e-17 637910006216 HMMPfam hit to PF00072, Response regulator receiver, score 1.8e-31 637910006217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637910006218 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637910006219 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637910006220 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 2.7e-31 637910006221 adenylosuccinate lyase; Provisional; Region: PRK09285 637910006222 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 637910006223 tetramer interface [polypeptide binding]; other site 637910006224 active site 637910006225 HMMPfam hit to PF08328, Adenylosuccinate lyase C-terminal, score 2.6e-90 637910006226 HMMPfam hit to PF00206, Fumarate lyase, score 4.1e-111 637910006227 PS00163 Fumarate lyases signature. 637910006228 putative lysogenization regulator; Reviewed; Region: PRK00218 637910006229 HMMPfam hit to PF04356, Protein of unknown function DUF489, score 1.1e-139 637910006230 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 637910006231 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 637910006232 HMMPfam hit to PF03054, tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase, score 6.6e-235 637910006233 PS00070 Aldehyde dehydrogenases cysteine active site. 637910006234 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 637910006235 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 637910006236 nudix motif; other site 637910006237 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 2.9e-30 637910006238 PS00893 mutT domain signature. 637910006239 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 637910006240 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 637910006241 probable active site [active] 637910006242 HMMPfam hit to PF00849, Pseudouridine synthase, score 3.5e-20 637910006243 PS01149 Rsu family of pseudouridine synthase signature. 637910006244 isocitrate dehydrogenase; Validated; Region: PRK07362 637910006245 isocitrate dehydrogenase; Reviewed; Region: PRK07006 637910006246 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 9.3e-166 637910006247 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 637910006248 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 637910006249 2 transmembrane helices predicted for ROD12271 by TMHMM2.0 at aa 7-29 and 44-66 637910006250 Pertussis toxin, subunit 1; Region: Pertussis_S1; cl03779 637910006251 2 transmembrane helices predicted for ROD12291 by TMHMM2.0 at aa 35-57 and 88-110 637910006252 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 637910006253 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 637910006254 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 1.4e-25 637910006255 1 transmembrane helix predicted for ROD12311 by TMHMM2.0 at aa 20-37 637910006256 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 637910006257 HMMPfam hit to PF00144, beta-lactamase, score 1.3e-53 637910006258 PS00146 beta-lactamase class-A active site. 637910006259 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 637910006260 dimerization interface [polypeptide binding]; other site 637910006261 HMMPfam hit to PF03860, Protein of unknown function DUF326, score 0.11 637910006262 HMMPfam hit to PF03860, Protein of unknown function DUF326, score 0.0013 637910006263 HMMPfam hit to PF03860, Protein of unknown function DUF326, score 0.085 637910006264 HMMPfam hit to PF03860, Protein of unknown function DUF326, score 0.052 637910006265 zinc/cadmium-binding protein; Provisional; Region: PRK10306 637910006266 HMMPfam hit to PF09223, YodA, score 3.5e-122 637910006267 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 637910006268 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 637910006269 Catalytic site [active] 637910006270 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, C-terminal, score 1.7e-14 637910006271 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 637910006272 Citrate transporter; Region: CitMHS; pfam03600 637910006273 12 transmembrane helices predicted for ROD12371 by TMHMM2.0 at aa 4-20, 27-49, 59-76, 88-110, 141-163, 176-198, 237-270, 283-305, 320-342, 349-366, 381-403 and 410-432 637910006274 HMMPfam hit to PF03600, Divalent ion symporter, score 2.4e-58 637910006275 putative aldolase; Validated; Region: PRK08130 637910006276 intersubunit interface [polypeptide binding]; other site 637910006277 active site 637910006278 Zn2+ binding site [ion binding]; other site 637910006279 HMMPfam hit to PF00596, Class II aldolase/adducin, N-terminal, score 6.7e-56 637910006280 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 637910006282 HMMPfam hit to PF07005, type III effector Hrp-dependent outers, score 2.2e-62 637910006283 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 637910006284 tartrate dehydrogenase; Region: TTC; TIGR02089 637910006285 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 2.9e-90 637910006286 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 637910006287 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 637910006288 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 637910006289 active site 637910006290 HMMPfam hit to PF04909, Amidohydrolase 2, score 5.4e-41 637910006291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910006292 D-galactonate transporter; Region: 2A0114; TIGR00893 637910006293 putative substrate translocation pore; other site 637910006294 11 transmembrane helices predicted for ROD12431 by TMHMM2.0 at aa 15-33, 54-76, 86-103, 110-132, 175-197, 250-272, 287-309, 316-338, 348-370, 383-405 and 415-434 637910006295 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 3.6e-52 637910006296 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006297 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637910006298 substrate binding pocket [chemical binding]; other site 637910006299 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637910006300 membrane-bound complex binding site; other site 637910006301 hinge residues; other site 637910006302 aconitate hydratase; Validated; Region: PRK09277 637910006303 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 637910006304 substrate binding site [chemical binding]; other site 637910006305 ligand binding site [chemical binding]; other site 637910006306 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 637910006307 substrate binding site [chemical binding]; other site 637910006308 HMMPfam hit to PF00330, Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, score 6.8e-127 637910006309 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006310 PS01244 Aconitase family signature 2. 637910006311 HMMPfam hit to PF00694, Aconitase A/isopropylmalate dehydratase small subunit, swivel, score 7.1e-32 637910006312 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910006313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910006314 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637910006315 dimerization interface [polypeptide binding]; other site 637910006316 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.1e-15 637910006317 Predicted helix-turn-helix motif with score 1057.000, SD 2.79 at aa 22-43, sequence QNLTRAARRKHTAVSAVSKRIA 637910006318 PS00044 Bacterial regulatory proteins, lysR family signature. 637910006319 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.5e-30 637910006320 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 637910006321 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 637910006322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637910006323 NAD(P) binding site [chemical binding]; other site 637910006324 active site 637910006325 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 8.7e-27 637910006326 PS00061 Short-chain dehydrogenases/reductases family signature. 637910006327 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 637910006328 Citrate transporter; Region: CitMHS; pfam03600 637910006329 11 transmembrane helices predicted for ROD12491 by TMHMM2.0 at aa 2-19, 24-43, 56-78, 107-129, 136-158, 173-195, 241-260, 264-281, 301-320, 340-362 and 420-442 637910006330 HMMPfam hit to PF03600, Divalent ion symporter, score 3.1e-136 637910006331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910006332 Transcriptional regulators [Transcription]; Region: GntR; COG1802 637910006333 DNA-binding site [nucleotide binding]; DNA binding site 637910006334 Transcriptional regulators [Transcription]; Region: FadR; COG2186 637910006335 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 637910006336 HMMPfam hit to PF07729, GntR, C-terminal, score 5.7e-06 637910006337 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 2.6e-20 637910006338 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 637910006339 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 637910006340 active site 637910006341 DNA binding site [nucleotide binding] 637910006342 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 637910006343 HMMPfam hit to PF00817, UMUC-like DNA-repair protein, score 3.4e-161 637910006344 leucine export protein LeuE; Provisional; Region: PRK10958 637910006345 6 transmembrane helices predicted for ROD12531 by TMHMM2.0 at aa 10-32, 45-67, 77-99, 120-142, 157-179 and 191-210 637910006346 HMMPfam hit to PF01810, Lysine exporter protein (LYSE/YGGA), score 2e-60 637910006347 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 637910006348 HMMPfam hit to PF09313, Protein of unknown function DUF1971, score 1.1e-38 637910006349 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 637910006350 HMMPfam hit to PF08956, Protein of unknown function DUF1869, score 3e-48 637910006351 6 transmembrane helices predicted for ROD12561 by TMHMM2.0 at aa 5-27, 37-59, 71-90, 100-122, 135-154 and 174-193 637910006352 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006353 hypothetical protein; Provisional; Region: PRK10457 637910006354 3 transmembrane helices predicted for ROD12571 by TMHMM2.0 at aa 2-21, 31-53 and 60-77 637910006355 HMMPfam hit to PF04226, Transglycosylase-associated protein, score 9.3e-20 637910006356 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 637910006357 Domain of unknown function (DUF333); Region: DUF333; pfam03891 637910006358 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006359 HMMPfam hit to PF03891, Protein of unknown function DUF333, score 5.4e-23 637910006360 PS00017 ATP/GTP-binding site motif A (P-loop). 637910006361 Uncharacterized conserved protein [Function unknown]; Region: COG3189 637910006362 HMMPfam hit to PF04343, Protein of unknown function DUF488, score 2.2e-42 637910006363 Uncharacterized conserved protein [Function unknown]; Region: COG1683 637910006364 HMMPfam hit to PF04463, Protein of unknown function DUF523, score 3.1e-60 637910006365 hypothetical protein; Validated; Region: PRK06186 637910006366 conserved cys residue [active] 637910006367 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 9.2e-08 637910006368 Predicted membrane protein [Function unknown]; Region: COG2707 637910006369 HMMPfam hit to PF04284, Protein of unknown function DUF441, transmembrame, score 1.4e-87 637910006370 4 transmembrane helices predicted for ROD12651 by TMHMM2.0 at aa 12-34, 49-71, 78-100 and 124-146 637910006371 1 transmembrane helix predicted for ROD12652 by TMHMM2.0 at aa 7-29 637910006372 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 637910006373 putative deacylase active site [active] 637910006374 HMMPfam hit to PF04073, YbaK/prolyl-tRNA synthetase associated region, score 1.7e-46 637910006375 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637910006376 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637910006377 metal binding site [ion binding]; metal-binding site 637910006378 active site 637910006379 I-site; other site 637910006380 HMMPfam hit to PF00990, GGDEF, score 1.3e-39 637910006381 2 transmembrane helices predicted for ROD12671 by TMHMM2.0 at aa 7-29 and 305-327 637910006382 hypothetical protein; Provisional; Region: PRK05325 637910006383 HMMPfam hit to PF04285, Protein of unknown function DUF444, score 2.6e-286 637910006384 PrkA family serine protein kinase; Provisional; Region: PRK15455 637910006385 AAA ATPase domain; Region: AAA_16; pfam13191 637910006386 Walker A motif; other site 637910006387 ATP binding site [chemical binding]; other site 637910006388 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 637910006389 HMMPfam hit to PF06798, PrkA serine kinase, score 4.7e-181 637910006390 HMMPfam hit to PF08298, PrkA AAA, score 1.9e-270 637910006391 PS00017 ATP/GTP-binding site motif A (P-loop). 637910006392 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 637910006393 HMMPfam hit to PF06629, MltA-interacting MipA, score 3.4e-99 637910006394 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637910006395 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637910006396 active site 637910006397 catalytic tetrad [active] 637910006398 HMMPfam hit to PF00248, Aldo/keto reductase, score 2.8e-70 637910006399 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 637910006400 active site 637910006401 phosphate binding residues; other site 637910006402 catalytic residues [active] 637910006403 HMMPfam hit to PF01263, Aldose 1-epimerase, score 1.5e-46 637910006404 PS00017 ATP/GTP-binding site motif A (P-loop). 637910006405 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 637910006406 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 637910006407 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 637910006408 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, score 1.9e-118 637910006409 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 637910006410 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, score 1.5e-98 637910006411 methionine sulfoxide reductase B; Provisional; Region: PRK00222 637910006412 SelR domain; Region: SelR; pfam01641 637910006413 HMMPfam hit to PF01641, Methionine sulphoxide reductase B, score 2.3e-79 637910006414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 637910006415 HMMPfam hit to PF07023, Protein of unknown function DUF1315, score 1.3e-61 637910006416 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 637910006417 active site 637910006418 HMMPfam hit to PF01844, HNH endonuclease, score 3.1e-05 637910006419 PS00190 Cytochrome c family heme-binding site signature. 637910006420 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 637910006421 Glyco_18 domain; Region: Glyco_18; smart00636 637910006422 active site 637910006423 HMMPfam hit to PF00704, Glycoside hydrolase, family 18, catalytic domain, score 1.9e-76 637910006424 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637910006425 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 637910006426 putative NAD(P) binding site [chemical binding]; other site 637910006427 catalytic Zn binding site [ion binding]; other site 637910006428 structural Zn binding site [ion binding]; other site 637910006429 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 8.2e-38 637910006430 PS00059 Zinc-containing alcohol dehydrogenases signature. 637910006431 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 1.2e-41 637910006432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910006433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910006434 12 transmembrane helices predicted for ROD12791 by TMHMM2.0 at aa 25-47, 59-81, 91-108, 115-137, 152-174, 181-203, 266-288, 301-323, 330-347, 354-376, 391-413 and 420-442 637910006435 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 2.4e-27 637910006436 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637910006437 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 637910006438 inhibitor binding site; inhibition site 637910006439 catalytic Zn binding site [ion binding]; other site 637910006440 structural Zn binding site [ion binding]; other site 637910006441 NADP binding site [chemical binding]; other site 637910006442 tetramer interface [polypeptide binding]; other site 637910006443 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 8.5e-41 637910006444 PS00059 Zinc-containing alcohol dehydrogenases signature. 637910006445 PS00693 Riboflavin synthase subunit alpha family signature. 637910006446 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 1.9e-39 637910006447 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006448 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 637910006449 intersubunit interface [polypeptide binding]; other site 637910006450 active site 637910006451 zinc binding site [ion binding]; other site 637910006452 Na+ binding site [ion binding]; other site 637910006453 HMMPfam hit to PF01116, Ketose-bisphosphate aldolase, class-II, score 6.5e-68 637910006454 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 637910006455 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 637910006456 substrate binding site [chemical binding]; other site 637910006457 ATP binding site [chemical binding]; other site 637910006458 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 8.2e-74 637910006459 PS00583 pfkB family of carbohydrate kinases signature 1. 637910006460 PS00584 pfkB family of carbohydrate kinases signature 2. 637910006461 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637910006462 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637910006463 active site 637910006464 catalytic tetrad [active] 637910006465 HMMPfam hit to PF00248, Aldo/keto reductase, score 6.3e-37 637910006466 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637910006467 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 637910006468 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637910006469 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 1.5e-18 637910006470 PS00894 Bacterial regulatory proteins, deoR family signature. 637910006471 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 1.2e-45 637910006472 pseudogene, disrupted by ICSCro1 insertion 637910006473 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.3e-28 637910006474 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910006475 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910006476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910006477 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910006478 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910006479 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910006480 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910006481 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910006482 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910006483 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910006484 Transposase; Region: HTH_Tnp_1; pfam01527 637910006485 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910006486 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910006487 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910006488 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 637910006489 Isochorismatase family; Region: Isochorismatase; pfam00857 637910006490 catalytic triad [active] 637910006491 metal binding site [ion binding]; metal-binding site 637910006492 conserved cis-peptide bond; other site 637910006493 HMMPfam hit to PF00857, Isochorismatase hydrolase, score 1.8e-81 637910006494 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 637910006495 active site 637910006496 homodimer interface [polypeptide binding]; other site 637910006497 HMMPfam hit to PF00710, Asparaginase/glutaminase, score 5.4e-139 637910006498 PS00917 Asparaginase / glutaminase active site signature 2. 637910006499 PS00144 Asparaginase / glutaminase active site signature 1. 637910006500 protease 4; Provisional; Region: PRK10949 637910006501 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 637910006502 tandem repeat interface [polypeptide binding]; other site 637910006503 oligomer interface [polypeptide binding]; other site 637910006504 active site residues [active] 637910006505 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 637910006506 tandem repeat interface [polypeptide binding]; other site 637910006507 oligomer interface [polypeptide binding]; other site 637910006508 active site residues [active] 637910006509 HMMPfam hit to PF01343, Peptidase S49, score 1.4e-78 637910006510 HMMPfam hit to PF01343, Peptidase S49, score 1.1e-57 637910006511 1 transmembrane helix predicted for ROD12921 by TMHMM2.0 at aa 21-43 637910006512 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 637910006513 putative FMN binding site [chemical binding]; other site 637910006514 HMMPfam hit to PF00881, Nitroreductase, score 7.9e-47 637910006515 selenophosphate synthetase; Provisional; Region: PRK00943 637910006516 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 637910006517 dimerization interface [polypeptide binding]; other site 637910006518 putative ATP binding site [chemical binding]; other site 637910006519 HMMPfam hit to PF00586, AIR synthase related protein, score 4.9e-11 637910006520 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006521 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 5.1e-23 637910006522 DNA topoisomerase III; Provisional; Region: PRK07726 637910006523 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 637910006524 active site 637910006525 putative interdomain interaction site [polypeptide binding]; other site 637910006526 putative metal-binding site [ion binding]; other site 637910006527 putative nucleotide binding site [chemical binding]; other site 637910006528 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 637910006529 domain I; other site 637910006530 DNA binding groove [nucleotide binding] 637910006531 phosphate binding site [ion binding]; other site 637910006532 domain II; other site 637910006533 domain III; other site 637910006534 nucleotide binding site [chemical binding]; other site 637910006535 catalytic site [active] 637910006536 domain IV; other site 637910006537 HMMPfam hit to PF01751, TOPRIM, score 9.7e-37 637910006538 HMMPfam hit to PF01131, DNA topoisomerase, type IA, central, score 2.8e-190 637910006539 PS00396 Prokaryotic DNA topoisomerase I active site. 637910006540 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637910006541 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637910006542 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637910006543 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.2e-27 637910006544 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 1.2e-17 637910006545 glutamate dehydrogenase; Provisional; Region: PRK09414 637910006546 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 637910006547 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 637910006548 NAD(P) binding site [chemical binding]; other site 637910006549 HMMPfam hit to PF00208, Glu/Leu/Phe/Val dehydrogenase, C-terminal, score 1.7e-141 637910006550 HMMPfam hit to PF02812, Glu/Leu/Phe/Val dehydrogenase, dimerisation region, score 1.3e-86 637910006551 PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 637910006552 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 637910006553 HMMPfam hit to PF07383, Protein of unknown function DUF1496, score 7.3e-46 637910006554 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 637910006555 active site 637910006556 8-oxo-dGMP binding site [chemical binding]; other site 637910006557 nudix motif; other site 637910006558 metal binding site [ion binding]; metal-binding site 637910006559 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 1.3e-30 637910006560 PS00893 mutT domain signature. 637910006561 Uncharacterized conserved protein [Function unknown]; Region: COG2128 637910006562 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 637910006563 1 transmembrane helix predicted for ROD13001 by TMHMM2.0 at aa 48-66 637910006564 HMMPfam hit to PF02627, Carboxymuconolactone decarboxylase, score 0.0009 637910006565 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 637910006566 5 transmembrane helices predicted for ROD13011 by TMHMM2.0 at aa 38-60, 80-102, 112-134, 147-169 and 174-196 637910006567 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 2.9e-18 637910006568 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 637910006569 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 637910006570 active site residue [active] 637910006571 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 637910006572 active site residue [active] 637910006573 PS00683 Rhodanese C-terminal signature. 637910006574 PS00380 Rhodanese signature 1. 637910006575 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006576 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 637910006577 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910006578 Walker A/P-loop; other site 637910006579 ATP binding site [chemical binding]; other site 637910006580 Q-loop/lid; other site 637910006581 ABC transporter signature motif; other site 637910006582 Walker B; other site 637910006583 D-loop; other site 637910006584 H-loop/switch region; other site 637910006585 HMMPfam hit to PF00005, ABC transporter related, score 1.8e-34 637910006586 PS00211 ABC transporters family signature. 637910006587 PS00017 ATP/GTP-binding site motif A (P-loop). 637910006588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910006589 dimer interface [polypeptide binding]; other site 637910006590 conserved gate region; other site 637910006591 putative PBP binding loops; other site 637910006592 ABC-ATPase subunit interface; other site 637910006593 11 transmembrane helices predicted for ROD13041 by TMHMM2.0 at aa 42-64, 76-95, 115-137, 164-186, 222-244, 265-287, 302-324, 331-350, 360-379, 412-434 and 466-488 637910006594 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 637910006595 hypothetical protein; Provisional; Region: PRK11622 637910006596 Uncharacterized conserved protein [Function unknown]; Region: COG0398 637910006597 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 637910006598 6 transmembrane helices predicted for ROD13061 by TMHMM2.0 at aa 10-29, 50-72, 87-109, 133-155, 165-182 and 195-217 637910006599 HMMPfam hit to PF09335, SNARE associated Golgi protein, score 3.3e-47 637910006600 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 637910006601 putative catalytic site [active] 637910006602 putative phosphate binding site [ion binding]; other site 637910006603 active site 637910006604 metal binding site A [ion binding]; metal-binding site 637910006605 DNA binding site [nucleotide binding] 637910006606 putative AP binding site [nucleotide binding]; other site 637910006607 putative metal binding site B [ion binding]; other site 637910006608 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 1e-52 637910006609 PS00728 AP endonucleases family 1 signature 3. 637910006610 PS00727 AP endonucleases family 1 signature 2. 637910006611 PS00726 AP endonucleases family 1 signature 1. 637910006612 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 637910006613 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 637910006614 inhibitor-cofactor binding pocket; inhibition site 637910006615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910006616 catalytic residue [active] 637910006617 HMMPfam hit to PF00202, Aminotransferase class-III, score 3.9e-147 637910006618 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 637910006619 arginine succinyltransferase; Provisional; Region: PRK10456 637910006620 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 637910006621 HMMPfam hit to PF04958, Arginine N-succinyltransferase beta subunit, score 3.4e-236 637910006622 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 637910006623 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 637910006624 NAD(P) binding site [chemical binding]; other site 637910006625 catalytic residues [active] 637910006626 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 3.2e-114 637910006627 PS00687 Aldehyde dehydrogenases glutamic acid active site. 637910006628 PS00070 Aldehyde dehydrogenases cysteine active site. 637910006629 succinylarginine dihydrolase; Provisional; Region: PRK13281 637910006630 HMMPfam hit to PF04996, Succinylarginine dihydrolase, score 0 637910006631 succinylglutamate desuccinylase; Provisional; Region: PRK05324 637910006632 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 637910006633 active site 637910006634 Zn binding site [ion binding]; other site 637910006635 HMMPfam hit to PF04952, Succinylglutamate desuccinylase/aspartoacylase, score 2.8e-83 637910006636 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 637910006637 dimer interface [polypeptide binding]; other site 637910006638 HMMPfam hit to PF07813, Region of unknown function, Spy-related, score 2.1e-05 637910006639 HMMPfam hit to PF07813, Region of unknown function, Spy-related, score 0.002 637910006640 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 637910006641 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 637910006642 GIY-YIG motif/motif A; other site 637910006643 active site 637910006644 catalytic site [active] 637910006645 putative DNA binding site [nucleotide binding]; other site 637910006646 metal binding site [ion binding]; metal-binding site 637910006647 HMMPfam hit to PF01541, Excinuclease ABC, C subunit, N-terminal, score 1e-13 637910006648 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 637910006649 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 637910006650 homodimer interface [polypeptide binding]; other site 637910006651 NAD binding pocket [chemical binding]; other site 637910006652 ATP binding pocket [chemical binding]; other site 637910006653 Mg binding site [ion binding]; other site 637910006654 active-site loop [active] 637910006655 HMMPfam hit to PF02540, NAD+ synthase, score 2.4e-129 637910006656 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 637910006657 1 transmembrane helix predicted for ROD13171 by TMHMM2.0 at aa 5-24 637910006658 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006659 HMMPfam hit to PF04355, SmpA/OmlA, score 1.3e-21 637910006660 Predicted helix-turn-helix motif with score 1071.000, SD 2.83 at aa 43-64, sequence MSRTQVAQIAGKPSSEVSMIHA 637910006661 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 637910006662 active site 637910006663 P-loop; other site 637910006664 phosphorylation site [posttranslational modification] 637910006665 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 7.6e-25 637910006666 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 637910006667 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 637910006668 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.1e-59 637910006669 8 transmembrane helices predicted for ROD13191 by TMHMM2.0 at aa 31-53, 85-107, 114-133, 143-165, 185-207, 227-249, 298-320 and 356-378 637910006670 PS00017 ATP/GTP-binding site motif A (P-loop). 637910006671 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637910006672 methionine cluster; other site 637910006673 active site 637910006674 phosphorylation site [posttranslational modification] 637910006675 metal binding site [ion binding]; metal-binding site 637910006676 HMMPfam hit to PF02255, Phosphotransferase system, lactose/cellobiose-specific IIA subunit, score 7.8e-50 637910006677 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 637910006678 Cupin domain; Region: Cupin_2; pfam07883 637910006679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910006680 HMMPfam hit to PF07883, Cupin 2, conserved barrel, score 1.1e-05 637910006681 PS00041 Bacterial regulatory proteins, araC family signature. 637910006682 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 8.8e-13 637910006683 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 637910006684 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 637910006685 NAD binding site [chemical binding]; other site 637910006686 sugar binding site [chemical binding]; other site 637910006687 divalent metal binding site [ion binding]; other site 637910006688 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637910006689 dimer interface [polypeptide binding]; other site 637910006690 HMMPfam hit to PF02056, Glycoside hydrolase, family 4, score 1e-219 637910006691 PS01324 Glycosyl hydrolases family 4 signature. 637910006692 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 637910006693 putative active site [active] 637910006694 YdjC motif; other site 637910006695 Mg binding site [ion binding]; other site 637910006696 putative homodimer interface [polypeptide binding]; other site 637910006697 HMMPfam hit to PF04794, YdjC-like protein, score 8.6e-111 637910006698 hydroperoxidase II; Provisional; Region: katE; PRK11249 637910006699 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 637910006700 tetramer interface [polypeptide binding]; other site 637910006701 heme binding pocket [chemical binding]; other site 637910006702 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 637910006703 domain interactions; other site 637910006704 HMMPfam hit to PF06628, Catalase-related, score 8.1e-29 637910006705 HMMPfam hit to PF00199, Catalase, N-terminal, score 8.8e-284 637910006706 PS00437 Catalase proximal heme-ligand signature. 637910006707 PS00438 Catalase proximal active site signature. 637910006708 cell division modulator; Provisional; Region: PRK10113 637910006709 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 637910006710 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 637910006711 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter, score 8.4e-113 637910006712 9 transmembrane helices predicted for ROD13261 by TMHMM2.0 at aa 5-20, 33-51, 71-93, 105-127, 180-202, 260-282, 340-362, 369-391 and 395-417 637910006713 inner membrane protein; Provisional; Region: PRK11648 637910006714 HMMPfam hit to PF04307, Protein of unknown function DUF457, transmembrane, score 1.2e-39 637910006715 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 637910006716 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 637910006717 NADP binding site [chemical binding]; other site 637910006718 homodimer interface [polypeptide binding]; other site 637910006719 active site 637910006720 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 9e-28 637910006721 PS00061 Short-chain dehydrogenases/reductases family signature. 637910006722 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 637910006723 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 637910006724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910006725 motif II; other site 637910006726 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 5.4e-30 637910006727 YniB-like protein; Region: YniB; pfam14002 637910006728 3 transmembrane helices predicted for ROD13301 by TMHMM2.0 at aa 15-37, 84-101 and 155-177 637910006729 Phosphotransferase enzyme family; Region: APH; pfam01636 637910006730 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 637910006731 active site 637910006732 ATP binding site [chemical binding]; other site 637910006733 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 637910006734 active site 637910006735 ATP binding site [chemical binding]; other site 637910006736 HMMPfam hit to PF03881, Fructosamine kinase, score 2e-213 637910006737 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 637910006738 6-phosphofructokinase 2; Provisional; Region: PRK10294 637910006739 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 637910006740 putative substrate binding site [chemical binding]; other site 637910006741 putative ATP binding site [chemical binding]; other site 637910006742 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 1.1e-70 637910006743 PS00584 pfkB family of carbohydrate kinases signature 2. 637910006744 PS00583 pfkB family of carbohydrate kinases signature 1. 637910006745 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 637910006746 HMMPfam hit to PF04338, Protein of unknown function DUF481, score 1.2e-119 637910006747 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 637910006748 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 3.2e-07 637910006749 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 637910006750 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 637910006751 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 637910006752 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 637910006753 active site 637910006754 dimer interface [polypeptide binding]; other site 637910006755 motif 1; other site 637910006756 motif 2; other site 637910006757 motif 3; other site 637910006758 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 637910006759 anticodon binding site; other site 637910006760 HMMPfam hit to PF02824, TGS, score 9.6e-17 637910006761 HMMPfam hit to PF07973, Threonyl/alanyl tRNA synthetase, SAD, score 1.3e-23 637910006762 HMMPfam hit to PF00587, Aminoacyl-tRNA synthetase, class II (G, H, P and S), score 1.2e-65 637910006763 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 637910006764 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910006765 HMMPfam hit to PF03129, Anticodon-binding, score 2.3e-33 637910006766 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 637910006767 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 637910006768 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 637910006769 HMMPfam hit to PF05198, Initiation factor 3, score 1.2e-48 637910006770 PS00938 Initiation factor 3 signature. 637910006771 HMMPfam hit to PF00707, Initiation factor 3, score 2.8e-55 637910006772 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 637910006773 HMMPfam hit to PF01632, Ribosomal protein L35, score 1.2e-32 637910006774 PS00936 Ribosomal protein L35 signature. 637910006775 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 637910006776 23S rRNA binding site [nucleotide binding]; other site 637910006777 L21 binding site [polypeptide binding]; other site 637910006778 L13 binding site [polypeptide binding]; other site 637910006779 HMMPfam hit to PF00453, Ribosomal protein L20, score 2.9e-69 637910006780 PS00937 Ribosomal protein L20 signature. 637910006781 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 637910006782 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 637910006783 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 637910006784 dimer interface [polypeptide binding]; other site 637910006785 motif 1; other site 637910006786 active site 637910006787 motif 2; other site 637910006788 motif 3; other site 637910006789 HMMPfam hit to PF02912, Phenylalanyl-tRNA synthetase, class II, N-terminal, score 6.1e-39 637910006790 HMMPfam hit to PF01409, Phenylalanyl-tRNA synthetase, class IIc, score 4.5e-169 637910006791 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 637910006792 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910006793 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 637910006794 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 637910006795 putative tRNA-binding site [nucleotide binding]; other site 637910006796 B3/4 domain; Region: B3_4; pfam03483 637910006797 tRNA synthetase B5 domain; Region: B5; smart00874 637910006798 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 637910006799 dimer interface [polypeptide binding]; other site 637910006800 motif 1; other site 637910006801 motif 3; other site 637910006802 motif 2; other site 637910006803 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 637910006804 HMMPfam hit to PF01588, tRNA-binding region, score 2.5e-44 637910006805 HMMPfam hit to PF03483, B3/4, score 2.4e-111 637910006806 HMMPfam hit to PF03484, tRNA synthetase, B5, score 2.4e-30 637910006807 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910006808 HMMPfam hit to PF03147, Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding, score 1.4e-46 637910006809 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 637910006810 IHF dimer interface [polypeptide binding]; other site 637910006811 IHF - DNA interface [nucleotide binding]; other site 637910006812 HMMPfam hit to PF00216, Histone-like bacterial DNA-binding protein, score 4.7e-47 637910006813 PS00045 Bacterial histone-like DNA-binding proteins signature. 637910006814 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 637910006815 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637910006816 ABC-ATPase subunit interface; other site 637910006817 dimer interface [polypeptide binding]; other site 637910006818 putative PBP binding regions; other site 637910006819 10 transmembrane helices predicted for ROD13441 by TMHMM2.0 at aa 13-35, 55-77, 90-107, 111-133, 145-167, 182-204, 224-243, 247-269, 274-293 and 303-322 637910006820 HMMPfam hit to PF01032, Bacterial transport system permease, score 4.7e-136 637910006821 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 637910006822 catalytic residues [active] 637910006823 dimer interface [polypeptide binding]; other site 637910006824 HMMPfam hit to PF00255, Glutathione peroxidase, score 1.4e-69 637910006825 PS00460 Glutathione peroxidases selenocysteine active site. 637910006826 PS00763 Glutathione peroxidases signature 2. 637910006827 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 637910006828 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 637910006829 Walker A/P-loop; other site 637910006830 ATP binding site [chemical binding]; other site 637910006831 Q-loop/lid; other site 637910006832 ABC transporter signature motif; other site 637910006833 Walker B; other site 637910006834 D-loop; other site 637910006835 H-loop/switch region; other site 637910006836 HMMPfam hit to PF00005, ABC transporter related, score 1.4e-39 637910006837 PS00017 ATP/GTP-binding site motif A (P-loop). 637910006838 PS00211 ABC transporters family signature. 637910006839 NlpC/P60 family; Region: NLPC_P60; pfam00877 637910006840 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006841 HMMPfam hit to PF00877, NLP/P60, score 8.5e-49 637910006842 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 637910006843 Uncharacterized conserved protein [Function unknown]; Region: COG0397 637910006844 hypothetical protein; Validated; Region: PRK00029 637910006845 HMMPfam hit to PF02696, Protein of unknown function UPF0061, score 1.8e-263 637910006846 Hemin uptake protein hemP; Region: hemP; cl10043 637910006847 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 637910006848 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 637910006849 HMMPfam hit to PF00793, DAHP synthetase I/KDSA, score 3e-173 637910006850 PEP synthetase regulatory protein; Provisional; Region: PRK05339 637910006851 HMMPfam hit to PF03618, Protein of unknown function DUF299, score 3.8e-165 637910006852 PS00017 ATP/GTP-binding site motif A (P-loop). 637910006853 phosphoenolpyruvate synthase; Validated; Region: PRK06464 637910006854 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 637910006855 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 637910006856 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 637910006857 HMMPfam hit to PF01326, Pyruvate phosphate dikinase, PEP/pyruvate-binding, score 1.5e-174 637910006858 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile region, score 2.5e-42 637910006859 PS00370 PEP-utilizing enzymes phosphorylation site signature. 637910006860 HMMPfam hit to PF02896, PEP-utilizing enzyme, score 4e-62 637910006861 PS00742 PEP-utilizing enzymes signature 2. 637910006862 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 637910006863 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 637910006864 active site 637910006865 catalytic residue [active] 637910006866 dimer interface [polypeptide binding]; other site 637910006867 HMMPfam hit to PF01487, Dehydroquinase class I, score 5.7e-101 637910006868 PS01028 Dehydroquinase class I active site. 637910006869 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 637910006870 putative symporter YagG; Provisional; Region: PRK09669 637910006871 11 transmembrane helices predicted for ROD13561 by TMHMM2.0 at aa 13-35, 40-62, 83-101, 116-138, 151-173, 183-205, 235-257, 267-289, 302-324, 365-387 and 407-429 637910006872 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.7e-05 637910006873 PS00872 Sodium:galactoside symporter family signature. 637910006874 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006875 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006876 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 637910006877 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 637910006878 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 637910006879 HMMPfam hit to PF00933, Glycoside hydrolase, family 3, N-terminal, score 7.1e-69 637910006880 HMMPfam hit to PF01915, Glycoside hydrolase, family 3, C-terminal, score 1.5e-67 637910006881 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 637910006882 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 637910006883 RHS Repeat; Region: RHS_repeat; pfam05593 637910006884 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 637910006885 RHS Repeat; Region: RHS_repeat; cl11982 637910006886 RHS Repeat; Region: RHS_repeat; pfam05593 637910006887 RHS Repeat; Region: RHS_repeat; pfam05593 637910006888 RHS Repeat; Region: RHS_repeat; pfam05593 637910006889 RHS Repeat; Region: RHS_repeat; cl11982 637910006890 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 637910006891 HMMPfam hit to PF05593, YD repeat, score 0.94 637910006892 HMMPfam hit to PF05593, YD repeat, score 0.00022 637910006893 HMMPfam hit to PF05593, YD repeat, score 2.3 637910006894 HMMPfam hit to PF05593, YD repeat, score 1.1e-07 637910006895 HMMPfam hit to PF05593, YD repeat, score 0.0011 637910006896 HMMPfam hit to PF05593, YD repeat, score 0.0017 637910006897 HMMPfam hit to PF05593, YD repeat, score 7.2e-07 637910006898 HMMPfam hit to PF05593, YD repeat, score 2.2 637910006899 HMMPfam hit to PF05593, YD repeat, score 1.9e-05 637910006900 HMMPfam hit to PF05593, YD repeat, score 0.005 637910006901 pseudogene, N-terminus missing, fragment 637910006902 putative inner membrane protein; Provisional; Region: PRK10983 637910006903 Domain of unknown function DUF20; Region: UPF0118; pfam01594 637910006904 HMMPfam hit to PF01594, Protein of unknown function UPF0118, score 5.5e-64 637910006905 9 transmembrane helices predicted for ROD13621 by TMHMM2.0 at aa 13-32, 36-53, 65-87, 159-181, 202-224, 228-250, 252-271, 276-295 and 308-330 637910006906 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006907 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006908 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 637910006909 FAD binding domain; Region: FAD_binding_4; pfam01565 637910006910 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 637910006911 HMMPfam hit to PF01565, FAD linked oxidase, N-terminal, score 2e-48 637910006912 PS00017 ATP/GTP-binding site motif A (P-loop). 637910006913 HMMPfam hit to PF02913, FAD linked oxidase, C-terminal, score 5.7e-72 637910006914 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910006915 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910006916 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 637910006917 CoenzymeA binding site [chemical binding]; other site 637910006918 subunit interaction site [polypeptide binding]; other site 637910006919 PHB binding site; other site 637910006920 HMMPfam hit to PF03061, Thioesterase superfamily, score 1e-18 637910006921 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 637910006922 HMMPfam hit to PF01521, HesB/YadR/YfhF, score 7e-37 637910006923 PS01152 Hypothetical hesB/yadR/yfhF family signature. 637910006924 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 637910006925 putative ABC transporter; Region: ycf24; CHL00085 637910006926 HMMPfam hit to PF01458, SUF system FeS cluster assembly, SufBD, score 7.4e-148 637910006927 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 637910006928 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 637910006929 Walker A/P-loop; other site 637910006930 ATP binding site [chemical binding]; other site 637910006931 Q-loop/lid; other site 637910006932 ABC transporter signature motif; other site 637910006933 Walker B; other site 637910006934 D-loop; other site 637910006935 H-loop/switch region; other site 637910006936 HMMPfam hit to PF00005, ABC transporter related, score 4.4e-28 637910006937 PS00017 ATP/GTP-binding site motif A (P-loop). 637910006938 PS00211 ABC transporters family signature. 637910006939 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 637910006940 FeS assembly protein SufD; Region: sufD; TIGR01981 637910006941 HMMPfam hit to PF01458, SUF system FeS cluster assembly, SufBD, score 1.7e-96 637910006942 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 637910006943 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 637910006944 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637910006945 catalytic residue [active] 637910006946 HMMPfam hit to PF00266, Aminotransferase, class V, score 1.1e-222 637910006947 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 637910006948 cysteine desufuration protein SufE; Provisional; Region: PRK09296 637910006949 HMMPfam hit to PF02657, Fe-S metabolism associated SufE, score 4.3e-66 637910006950 L,D-transpeptidase; Provisional; Region: PRK10190 637910006951 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637910006952 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637910006953 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 2.4e-08 637910006954 HMMPfam hit to PF03734, ErfK/YbiS/YcfS/YnhG, score 6.5e-59 637910006955 murein lipoprotein; Provisional; Region: PRK15396 637910006956 HMMPfam hit to PF04728, LPP motif, score 0.013 637910006957 HMMPfam hit to PF04728, LPP motif, score 0.012 637910006958 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006959 pyruvate kinase; Provisional; Region: PRK09206 637910006960 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 637910006961 domain interfaces; other site 637910006962 active site 637910006963 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta, score 1.8e-28 637910006964 HMMPfam hit to PF00224, Pyruvate kinase, barrel, score 3.8e-214 637910006965 PS00110 Pyruvate kinase active site signature. 637910006966 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 637910006967 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 637910006968 Walker A/P-loop; other site 637910006969 ATP binding site [chemical binding]; other site 637910006970 Q-loop/lid; other site 637910006971 ABC transporter signature motif; other site 637910006972 Walker B; other site 637910006973 D-loop; other site 637910006974 H-loop/switch region; other site 637910006975 NIL domain; Region: NIL; pfam09383 637910006976 HMMPfam hit to PF00005, ABC transporter related, score 6.8e-72 637910006977 PS00017 ATP/GTP-binding site motif A (P-loop). 637910006978 PS00211 ABC transporters family signature. 637910006979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910006980 dimer interface [polypeptide binding]; other site 637910006981 conserved gate region; other site 637910006982 putative PBP binding loops; other site 637910006983 ABC-ATPase subunit interface; other site 637910006984 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1e-16 637910006985 5 transmembrane helices predicted for ROD13771 by TMHMM2.0 at aa 30-52, 59-81, 91-113, 151-173 and 193-215 637910006986 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910006987 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 637910006988 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 637910006989 PS00430 TonB-dependent receptor proteins signature 1. 637910006990 HMMPfam hit to PF03180, NLPA lipoprotein, score 2.1e-102 637910006991 hypothetical protein; Provisional; Region: PRK10292 637910006992 hypothetical protein; Provisional; Region: PRK09898 637910006993 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637910006994 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910006995 PS00190 Cytochrome c family heme-binding site signature. 637910006996 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0042 637910006997 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 3.7e-05 637910006998 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910006999 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 3.9e-07 637910007000 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910007001 putative oxidoreductase; Provisional; Region: PRK09849 637910007002 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 637910007003 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 637910007004 HMMPfam hit to PF02730, Aldehyde ferredoxin oxidoreductase, N-terminal, score 3.7e-123 637910007005 HMMPfam hit to PF01314, Aldehyde ferredoxin oxidoreductase, C-terminal, score 1.5e-234 637910007006 hypothetical protein; Provisional; Region: PRK09947 637910007007 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 637910007008 4Fe-4S binding domain; Region: Fer4; cl02805 637910007009 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0095 637910007010 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 4.4e-06 637910007011 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910007012 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 637910007013 5 transmembrane helices predicted for ROD13841 by TMHMM2.0 at aa 28-50, 76-98, 113-135, 182-204 and 219-241 637910007014 HMMPfam hit to PF01292, Cytochrome B561, bacterial, score 0.00011 637910007015 hypothetical protein; Provisional; Region: PRK09946 637910007016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910007017 dimer interface [polypeptide binding]; other site 637910007018 conserved gate region; other site 637910007019 putative PBP binding loops; other site 637910007020 ABC-ATPase subunit interface; other site 637910007021 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1e-12 637910007022 5 transmembrane helices predicted for ROD13861 by TMHMM2.0 at aa 30-52, 65-87, 97-119, 155-177 and 192-214 637910007023 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910007024 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007025 pseudogene, N-terminus missing, fragment 637910007026 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 0.012 637910007027 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637910007028 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637910007029 Walker A/P-loop; other site 637910007030 ATP binding site [chemical binding]; other site 637910007031 Q-loop/lid; other site 637910007032 ABC transporter signature motif; other site 637910007033 Walker B; other site 637910007034 D-loop; other site 637910007035 H-loop/switch region; other site 637910007036 HMMPfam hit to PF00005, ABC transporter related, score 2.3e-64 637910007037 PS00211 ABC transporters family signature. 637910007038 PS00017 ATP/GTP-binding site motif A (P-loop). 637910007039 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637910007040 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637910007041 substrate binding pocket [chemical binding]; other site 637910007042 membrane-bound complex binding site; other site 637910007043 hinge residues; other site 637910007044 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 5.2e-72 637910007045 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 637910007046 hypothetical protein; Provisional; Region: PRK09897 637910007047 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 637910007048 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910007049 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910007050 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910007051 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910007052 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910007053 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910007054 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910007055 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910007056 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910007057 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910007058 Transposase; Region: HTH_Tnp_1; pfam01527 637910007059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910007060 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910007061 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910007062 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 637910007063 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007064 short chain dehydrogenase; Provisional; Region: PRK06181 637910007065 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 637910007066 putative NAD(P) binding site [chemical binding]; other site 637910007067 active site 637910007068 1 transmembrane helix predicted for ROD13951 by TMHMM2.0 at aa 307-324 637910007069 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 2.8e-22 637910007070 PS00061 Short-chain dehydrogenases/reductases family signature. 637910007071 putative monooxygenase; Provisional; Region: PRK11118 637910007072 HMMPfam hit to PF08803, Mono-oxygenase, YdhR, score 4.2e-70 637910007073 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 637910007074 Mechanosensitive ion channel; Region: MS_channel; pfam00924 637910007075 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 5.6e-71 637910007076 4 transmembrane helices predicted for ROD13971 by TMHMM2.0 at aa 20-42, 71-90, 136-158 and 165-187 637910007077 hypothetical protein; Provisional; Region: PRK06847 637910007078 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 637910007079 HMMPfam hit to PF00890, Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal, score 0.00021 637910007080 1 transmembrane helix predicted for ROD13981 by TMHMM2.0 at aa 5-22 637910007081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910007082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910007083 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 637910007084 putative substrate binding pocket [chemical binding]; other site 637910007085 putative dimerization interface [polypeptide binding]; other site 637910007086 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 3.1e-13 637910007087 Predicted helix-turn-helix motif with score 1190.000, SD 3.24 at aa 21-42, sequence QNITRAAGRLHMTQSATSGVLN 637910007088 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.2e-05 637910007089 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 637910007090 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 637910007091 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 637910007092 putative active site [active] 637910007093 putative metal binding site [ion binding]; other site 637910007094 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 0.00052 637910007095 PS00934 Glyoxalase I signature 1. 637910007096 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 637910007097 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 637910007098 HMMPfam hit to PF01557, Fumarylacetoacetase, C-terminal-like, score 1.4e-05 637910007099 Putative cyclase; Region: Cyclase; pfam04199 637910007100 HMMPfam hit to PF04199, cyclase, score 1.8e-45 637910007101 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 637910007102 multidrug efflux protein; Reviewed; Region: PRK01766 637910007103 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 637910007104 cation binding site [ion binding]; other site 637910007105 12 transmembrane helices predicted for ROD14061 by TMHMM2.0 at aa 12-34, 44-66, 91-113, 128-147, 160-180, 190-212, 241-263, 278-300, 313-335, 350-367, 387-409 and 419-438 637910007106 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 1.4e-45 637910007107 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 1.9e-49 637910007108 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 637910007109 Lumazine binding domain; Region: Lum_binding; pfam00677 637910007110 Lumazine binding domain; Region: Lum_binding; pfam00677 637910007111 HMMPfam hit to PF00677, Lumazine-binding protein, score 2e-45 637910007112 PS00693 Riboflavin synthase subunit alpha family signature. 637910007113 HMMPfam hit to PF00677, Lumazine-binding protein, score 5.1e-46 637910007114 PS00693 Riboflavin synthase subunit alpha family signature. 637910007115 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 637910007116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 637910007117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910007118 S-adenosylmethionine binding site [chemical binding]; other site 637910007119 HMMPfam hit to PF02353, Cyclopropane-fatty-acyl-phospholipid synthase, score 4.2e-166 637910007120 putative transporter; Provisional; Region: PRK11043 637910007121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910007122 putative substrate translocation pore; other site 637910007123 12 transmembrane helices predicted for ROD14091 by TMHMM2.0 at aa 7-29, 39-61, 73-92, 97-119, 131-153, 158-180, 208-230, 235-257, 270-289, 299-321, 333-355 and 359-377 637910007124 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 9.7e-55 637910007125 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007126 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 637910007127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910007128 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637910007129 dimerization interface [polypeptide binding]; other site 637910007130 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 3.5e-18 637910007131 Predicted helix-turn-helix motif with score 1104.000, SD 2.95 at aa 17-38, sequence GSFSSAAQELHRVPSAVSYTVR 637910007132 PS00044 Bacterial regulatory proteins, lysR family signature. 637910007133 HMMPfam hit to PF03466, LysR, substrate-binding, score 8.9e-28 637910007134 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 637910007135 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910007136 DNA binding site [nucleotide binding] 637910007137 domain linker motif; other site 637910007138 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 637910007139 dimerization interface [polypeptide binding]; other site 637910007140 ligand binding site [chemical binding]; other site 637910007141 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 1.3e-25 637910007142 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 1.6e-12 637910007143 Predicted helix-turn-helix motif with score 2035.000, SD 6.12 at aa 2-23, sequence ATIKDVAKRANVSTTTVSHVIN 637910007144 PS00356 Bacterial regulatory proteins, lacI family signature. 637910007145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910007146 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637910007147 putative substrate translocation pore; other site 637910007148 12 transmembrane helices predicted for ROD14131 by TMHMM2.0 at aa 5-27, 42-64, 71-90, 100-122, 129-151, 156-178, 203-225, 235-257, 264-286, 291-308, 329-351 and 355-377 637910007149 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 3e-43 637910007150 superoxide dismutase; Provisional; Region: PRK10543 637910007151 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 637910007152 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 637910007153 HMMPfam hit to PF02777, Manganese and iron superoxide dismutase, score 2.5e-81 637910007154 PS00088 Manganese and iron superoxide dismutases signature. 637910007155 HMMPfam hit to PF00081, Manganese and iron superoxide dismutase, score 7.5e-53 637910007156 PS00017 ATP/GTP-binding site motif A (P-loop). 637910007157 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 637910007158 NlpC/P60 family; Region: NLPC_P60; pfam00877 637910007159 HMMPfam hit to PF00877, NLP/P60, score 9.9e-55 637910007160 1 transmembrane helix predicted for ROD14151 by TMHMM2.0 at aa 7-24 637910007161 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 637910007162 putative GSH binding site [chemical binding]; other site 637910007163 catalytic residues [active] 637910007164 HMMPfam hit to PF00462, Glutaredoxin, score 9.6e-28 637910007165 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007166 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 637910007167 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 637910007168 dimer interface [polypeptide binding]; other site 637910007169 catalytic site [active] 637910007170 putative active site [active] 637910007171 putative substrate binding site [chemical binding]; other site 637910007172 HMMPfam hit to PF00929, Exonuclease, RNase T and DNA polymerase III, score 1e-36 637910007173 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 637910007174 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 637910007175 dimer interface [polypeptide binding]; other site 637910007176 active site 637910007177 metal binding site [ion binding]; metal-binding site 637910007178 glutathione binding site [chemical binding]; other site 637910007179 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 4.2e-41 637910007180 PS00935 Glyoxalase I signature 2. 637910007181 PS00934 Glyoxalase I signature 1. 637910007182 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 637910007183 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 637910007184 FMN binding site [chemical binding]; other site 637910007185 active site 637910007186 substrate binding site [chemical binding]; other site 637910007187 catalytic residue [active] 637910007188 HMMPfam hit to PF00724, NADH:flavin oxidoreductase/NADH oxidase, N-terminal, score 7.6e-102 637910007189 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 637910007190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 637910007191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637910007192 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007193 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 6e-10 637910007194 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637910007195 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637910007196 active site 637910007197 catalytic tetrad [active] 637910007198 HMMPfam hit to PF00248, Aldo/keto reductase, score 2.4e-69 637910007199 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 637910007200 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 637910007201 E-class dimer interface [polypeptide binding]; other site 637910007202 P-class dimer interface [polypeptide binding]; other site 637910007203 active site 637910007204 Cu2+ binding site [ion binding]; other site 637910007205 Zn2+ binding site [ion binding]; other site 637910007206 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007207 HMMPfam hit to PF00080, Superoxide dismutase, copper/zinc binding, score 1.7e-31 637910007208 PS00087 Copper/Zinc superoxide dismutase signature 1. 637910007209 PS00332 Copper/Zinc superoxide dismutase signature 2. 637910007210 Fusaric acid resistance protein family; Region: FUSC; pfam04632 637910007211 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 637910007212 10 transmembrane helices predicted for ROD14231 by TMHMM2.0 at aa 21-43, 47-69, 76-98, 118-140, 153-170, 382-404, 411-433, 438-455, 462-481 and 496-515 637910007213 HMMPfam hit to PF04632, Fusaric acid resistance protein conserved region, score 7.8e-47 637910007214 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007215 PS00435 Peroxidases proximal heme-ligand signature. 637910007216 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 637910007217 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637910007218 HlyD family secretion protein; Region: HlyD_3; pfam13437 637910007219 HMMPfam hit to PF00529, Secretion protein HlyD, score 7.3e-45 637910007220 1 transmembrane helix predicted for ROD14241 by TMHMM2.0 at aa 7-26 637910007221 transcriptional regulator SlyA; Provisional; Region: PRK03573 637910007222 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 637910007223 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 5.6e-24 637910007224 Predicted helix-turn-helix motif with score 1097.000, SD 2.92 at aa 47-68, sequence QSQIQLAKAIGIEQPSLVRTLD 637910007225 PS01117 Bacterial regulatory proteins, marR family signature. 637910007226 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 637910007227 HMMPfam hit to PF05433, Rickettsia 17 kDa surface antigen, score 4.5e-10 637910007228 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007229 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 637910007230 HMMPfam hit to PF03702, Protein of unknown function UPF0075, score 2e-247 637910007231 lysozyme inhibitor; Provisional; Region: PRK11372 637910007232 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 637910007233 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007234 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 637910007235 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 637910007236 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 637910007237 HMMPfam hit to PF01243, Pyridoxamine 5'-phosphate oxidase-related, FMN-binding core, score 4.2e-31 637910007238 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 637910007239 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 637910007240 active site 637910007241 HIGH motif; other site 637910007242 dimer interface [polypeptide binding]; other site 637910007243 KMSKS motif; other site 637910007244 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637910007245 RNA binding surface [nucleotide binding]; other site 637910007246 HMMPfam hit to PF00579, Aminoacyl-tRNA synthetase, class Ib, score 9.5e-136 637910007247 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 637910007248 HMMPfam hit to PF01479, RNA-binding S4, score 0.0022 637910007249 pyridoxamine kinase; Validated; Region: PRK05756 637910007250 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 637910007251 dimer interface [polypeptide binding]; other site 637910007252 pyridoxal binding site [chemical binding]; other site 637910007253 ATP binding site [chemical binding]; other site 637910007254 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 9.7e-07 637910007255 glutathionine S-transferase; Provisional; Region: PRK10542 637910007256 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 637910007257 C-terminal domain interface [polypeptide binding]; other site 637910007258 GSH binding site (G-site) [chemical binding]; other site 637910007259 dimer interface [polypeptide binding]; other site 637910007260 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 637910007261 N-terminal domain interface [polypeptide binding]; other site 637910007262 dimer interface [polypeptide binding]; other site 637910007263 substrate binding pocket (H-site) [chemical binding]; other site 637910007264 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 5e-20 637910007265 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 8.3e-08 637910007266 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 637910007267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910007268 putative substrate translocation pore; other site 637910007269 POT family; Region: PTR2; pfam00854 637910007270 14 transmembrane helices predicted for ROD14331 by TMHMM2.0 at aa 22-44, 59-81, 90-107, 112-129, 150-172, 177-199, 220-239, 243-262, 275-292, 323-340, 353-371, 386-408, 415-437 and 457-479 637910007271 HMMPfam hit to PF00854, TGF-beta receptor, type I/II extracellular region, score 1.4e-108 637910007272 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 637910007273 PS00778 Histidine acid phosphatases active site signature. 637910007274 PS01022 PTR2 family proton/oligopeptide symporters signature 1. 637910007275 endonuclease III; Provisional; Region: PRK10702 637910007276 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 637910007277 minor groove reading motif; other site 637910007278 helix-hairpin-helix signature motif; other site 637910007279 substrate binding pocket [chemical binding]; other site 637910007280 active site 637910007281 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 637910007282 PS00764 Endonuclease III iron-sulfur binding region signature. 637910007283 HMMPfam hit to PF00730, HhH-GPD, score 8.5e-20 637910007284 PS01155 Endonuclease III family signature. 637910007285 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 2e-07 637910007286 electron transport complex RsxE subunit; Provisional; Region: PRK12405 637910007287 5 transmembrane helices predicted for ROD14351 by TMHMM2.0 at aa 34-56, 69-86, 90-112, 125-147 and 184-206 637910007288 HMMPfam hit to PF02508, RnfA-Nqr electron transport subunit, score 2.6e-117 637910007289 electron transport complex protein RnfG; Validated; Region: PRK01908 637910007290 HMMPfam hit to PF04205, FMN-binding, score 6.4e-23 637910007291 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 637910007292 HMMPfam hit to PF03116, NQR2 and RnfD, score 5.9e-191 637910007293 10 transmembrane helices predicted for ROD14371 by TMHMM2.0 at aa 20-39, 43-62, 69-91, 95-117, 124-143, 214-236, 243-262, 272-294, 301-318 and 323-342 637910007294 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007295 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 637910007296 SLBB domain; Region: SLBB; pfam10531 637910007297 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637910007298 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.00015 637910007299 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910007300 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0033 637910007301 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910007302 HMMPfam hit to PF01512, Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit, score 2.1e-98 637910007303 PS00070 Aldehyde dehydrogenases cysteine active site. 637910007304 electron transport complex protein RnfB; Provisional; Region: PRK05113 637910007305 Putative Fe-S cluster; Region: FeS; pfam04060 637910007306 4Fe-4S binding domain; Region: Fer4; pfam00037 637910007307 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 8.3e-06 637910007308 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910007309 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 4.1e-07 637910007310 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910007311 HMMPfam hit to PF04060, Fe-S cluster, score 1.2e-14 637910007312 1 transmembrane helix predicted for ROD14391 by TMHMM2.0 at aa 4-26 637910007313 electron transport complex protein RsxA; Provisional; Region: PRK05151 637910007314 HMMPfam hit to PF02508, RnfA-Nqr electron transport subunit, score 3.6e-116 637910007315 6 transmembrane helices predicted for ROD14401 by TMHMM2.0 at aa 5-27, 37-59, 66-88, 103-125, 132-154 and 169-191 637910007316 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 637910007317 4 transmembrane helices predicted for ROD14411 by TMHMM2.0 at aa 13-35, 55-77, 90-109 and 114-133 637910007318 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 637910007319 HMMPfam hit to PF05321, Haemolysin expression modulating, score 4.3e-36 637910007320 1 transmembrane helix predicted for ROD14441 by TMHMM2.0 at aa 4-26 637910007321 putative oxidoreductase; Provisional; Region: PRK11579 637910007322 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637910007323 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 637910007324 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 1.5e-42 637910007325 HMMPfam hit to PF02894, Oxidoreductase, C-terminal, score 8.6e-28 637910007326 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 637910007327 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 637910007328 active site 637910007329 purine riboside binding site [chemical binding]; other site 637910007330 HMMPfam hit to PF00962, Adenosine/AMP deaminase, score 5e-131 637910007331 Predicted helix-turn-helix motif with score 1237.000, SD 3.40 at aa 289-310, sequence HEYTVAAPAAGLSREQIRQAQI 637910007332 PS00485 Adenosine and AMP deaminase signature. 637910007333 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 637910007334 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637910007335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910007336 homodimer interface [polypeptide binding]; other site 637910007337 catalytic residue [active] 637910007338 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 7.5e-73 637910007339 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 637910007340 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 637910007341 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637910007342 active site turn [active] 637910007343 phosphorylation site [posttranslational modification] 637910007344 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 3.5e-19 637910007345 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 637910007346 8 transmembrane helices predicted for ROD14481 by TMHMM2.0 at aa 21-43, 72-89, 96-118, 138-160, 183-205, 325-347, 352-374 and 397-419 637910007347 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 2.2e-113 637910007348 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 637910007349 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910007350 DNA binding site [nucleotide binding] 637910007351 domain linker motif; other site 637910007352 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 637910007353 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 9.1e-12 637910007354 Predicted helix-turn-helix motif with score 1696.000, SD 4.96 at aa 7-28, sequence ITIHDVALAAGVSVSTVSLVLS 637910007355 PS00356 Bacterial regulatory proteins, lacI family signature. 637910007356 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 9.2e-100 637910007357 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 637910007358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 637910007359 HMMPfam hit to PF06097, Protein of unknown function DUF945, bacterial, score 3.1e-277 637910007360 PS00017 ATP/GTP-binding site motif A (P-loop). 637910007361 1 transmembrane helix predicted for ROD14501 by TMHMM2.0 at aa 5-24 637910007362 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 637910007363 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 637910007364 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 637910007365 HMMPfam hit to PF01238, Mannose-6-phosphate isomerase, type I, score 4.6e-182 637910007366 PS00966 Phosphomannose isomerase type I signature 2. 637910007367 PS00965 Phosphomannose isomerase type I signature 1. 637910007368 fumarate hydratase; Provisional; Region: PRK15389 637910007369 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 637910007370 Fumarase C-terminus; Region: Fumerase_C; pfam05683 637910007371 HMMPfam hit to PF05681, Fe-S type hydro-lyases tartrate/fumarate alpha region, score 5.6e-142 637910007372 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007373 HMMPfam hit to PF05683, Fe-S type hydro-lyases tartrate/fumarate beta region, score 2.9e-117 637910007374 PS00163 Fumarate lyases signature. 637910007375 fumarate hydratase; Reviewed; Region: fumC; PRK00485 637910007376 Class II fumarases; Region: Fumarase_classII; cd01362 637910007377 active site 637910007378 tetramer interface [polypeptide binding]; other site 637910007379 HMMPfam hit to PF00206, Fumarate lyase, score 1.7e-195 637910007380 PS00163 Fumarate lyases signature. 637910007381 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 637910007382 HMMPfam hit to PF05472, DNA replication terminus site-binding protein, score 8.7e-217 637910007383 sensor protein RstB; Provisional; Region: PRK10604 637910007384 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637910007385 dimerization interface [polypeptide binding]; other site 637910007386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637910007387 dimer interface [polypeptide binding]; other site 637910007388 phosphorylation site [posttranslational modification] 637910007389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910007390 ATP binding site [chemical binding]; other site 637910007391 Mg2+ binding site [ion binding]; other site 637910007392 G-X-G motif; other site 637910007393 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1e-36 637910007394 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.8e-11 637910007395 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 3.5e-07 637910007396 2 transmembrane helices predicted for ROD14551 by TMHMM2.0 at aa 5-27 and 139-156 637910007397 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 637910007398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910007399 active site 637910007400 phosphorylation site [posttranslational modification] 637910007401 intermolecular recognition site; other site 637910007402 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637910007403 DNA binding site [nucleotide binding] 637910007404 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1.5e-20 637910007405 HMMPfam hit to PF00072, Response regulator receiver, score 4.6e-22 637910007406 GlpM protein; Region: GlpM; pfam06942 637910007407 4 transmembrane helices predicted for ROD14571 by TMHMM2.0 at aa 2-21, 25-47, 59-81 and 86-108 637910007408 HMMPfam hit to PF06942, GlpM, score 1e-74 637910007409 dihydromonapterin reductase; Provisional; Region: PRK06483 637910007410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637910007411 NAD(P) binding site [chemical binding]; other site 637910007412 active site 637910007413 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 4.1e-06 637910007414 PS00061 Short-chain dehydrogenases/reductases family signature. 637910007415 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 637910007416 Spore germination protein; Region: Spore_permease; cl17796 637910007417 13 transmembrane helices predicted for ROD14591 by TMHMM2.0 at aa 5-24, 39-61, 90-112, 127-149, 156-178, 203-222, 235-257, 277-299, 329-351, 356-378, 385-403, 408-427 and 440-459 637910007418 HMMPfam hit to PF00324, Amino acid permease-associated region, score 0.00075 637910007419 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007420 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 637910007421 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 637910007422 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 637910007423 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 6.4e-06 637910007424 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 5.2e-11 637910007425 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 637910007426 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 637910007427 ligand binding site [chemical binding]; other site 637910007428 homodimer interface [polypeptide binding]; other site 637910007429 NAD(P) binding site [chemical binding]; other site 637910007430 trimer interface B [polypeptide binding]; other site 637910007431 trimer interface A [polypeptide binding]; other site 637910007432 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 637910007433 HMMPfam hit to PF05222, Alanine dehydrogenase/PNT, N-terminal, score 1.3e-73 637910007434 PS00836 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1 637910007435 HMMPfam hit to PF01262, Alanine dehydrogenase/PNT, C-terminal, score 2.8e-90 637910007436 5 transmembrane helices predicted for ROD14621 by TMHMM2.0 at aa 169-191, 403-420, 424-446, 453-472 and 477-499 637910007437 PS00837 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2 637910007438 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007439 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 637910007440 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 637910007441 HMMPfam hit to PF02233, NAD(P) transhydrogenase, beta subunit, score 0 637910007442 9 transmembrane helices predicted for ROD14631 by TMHMM2.0 at aa 5-24, 33-52, 57-74, 86-108, 121-143, 164-181, 185-207, 214-236 and 240-259 637910007443 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 637910007444 Domain of unknown function DUF20; Region: UPF0118; pfam01594 637910007445 HMMPfam hit to PF01594, Protein of unknown function UPF0118, score 5.6e-82 637910007446 8 transmembrane helices predicted for ROD14641 by TMHMM2.0 at aa 7-29, 33-50, 62-84, 141-163, 196-218, 222-244, 257-279 and 299-321 637910007447 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 637910007448 4 transmembrane helices predicted for ROD14652 by TMHMM2.0 at aa 2-19, 29-51, 56-78 and 82-101 637910007449 HMMPfam hit to PF00893, Small multidrug resistance protein, score 9.9e-37 637910007450 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 637910007451 HMMPfam hit to PF00893, Small multidrug resistance protein, score 8.7e-45 637910007452 4 transmembrane helices predicted for ROD14661 by TMHMM2.0 at aa 10-29, 36-53, 63-85 and 92-106 637910007453 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 637910007454 HMMPfam hit to PF00089, Peptidase S1 and S6, chymotrypsin/Hap, score 1.2e-05 637910007455 PS00135 Serine proteases, trypsin family, serine active site. 637910007456 PS00134 Serine proteases, trypsin family, histidine active site. 637910007457 1 transmembrane helix predicted for ROD14681 by TMHMM2.0 at aa 13-35 637910007458 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 637910007459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910007460 putative substrate translocation pore; other site 637910007461 12 transmembrane helices predicted for ROD14691 by TMHMM2.0 at aa 38-60, 75-96, 103-125, 129-151, 158-180, 190-212, 241-263, 273-290, 302-324, 329-351, 364-386 and 390-412 637910007462 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 2.7e-43 637910007463 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007464 PS00216 Sugar transport proteins signature 1. 637910007465 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 637910007466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910007467 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 637910007468 dimerization interface [polypeptide binding]; other site 637910007469 substrate binding pocket [chemical binding]; other site 637910007470 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.1e-19 637910007471 Predicted helix-turn-helix motif with score 1561.000, SD 4.50 at aa 18-39, sequence LHFGRAAARLNISQPPLSQQIQ 637910007472 PS00044 Bacterial regulatory proteins, lysR family signature. 637910007473 HMMPfam hit to PF03466, LysR, substrate-binding, score 3e-49 637910007474 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 637910007475 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637910007476 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637910007477 nucleotide binding site [chemical binding]; other site 637910007478 HMMPfam hit to PF00480, ROK, score 1.7e-35 637910007479 PS00501 Signal peptidases I serine active site. 637910007480 putative dithiobiotin synthetase; Provisional; Region: PRK12374 637910007481 AAA domain; Region: AAA_26; pfam13500 637910007482 HMMPfam hit to PF01656, Cobyrinic acid a,c-diamide synthase, score 1.1e-26 637910007483 PS00017 ATP/GTP-binding site motif A (P-loop). 637910007484 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 637910007485 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 637910007486 Walker A/P-loop; other site 637910007487 ATP binding site [chemical binding]; other site 637910007488 Q-loop/lid; other site 637910007489 ABC transporter signature motif; other site 637910007490 Walker B; other site 637910007491 D-loop; other site 637910007492 H-loop/switch region; other site 637910007493 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 637910007494 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 1.7e-17 637910007495 HMMPfam hit to PF00005, ABC transporter related, score 8.3e-59 637910007496 PS00211 ABC transporters family signature. 637910007497 PS00017 ATP/GTP-binding site motif A (P-loop). 637910007498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910007499 dimer interface [polypeptide binding]; other site 637910007500 conserved gate region; other site 637910007501 ABC-ATPase subunit interface; other site 637910007502 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1e-22 637910007503 6 transmembrane helices predicted for ROD14741 by TMHMM2.0 at aa 22-44, 51-73, 78-100, 130-149, 154-176 and 183-202 637910007504 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910007505 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 637910007506 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 637910007507 HMMPfam hit to PF04069, Substrate-binding region of ABC-type glycine betaine transport system, score 6.4e-88 637910007508 1 transmembrane helix predicted for ROD14751 by TMHMM2.0 at aa 7-29 637910007509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910007510 dimer interface [polypeptide binding]; other site 637910007511 conserved gate region; other site 637910007512 putative PBP binding loops; other site 637910007513 ABC-ATPase subunit interface; other site 637910007514 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.7e-26 637910007515 5 transmembrane helices predicted for ROD14761 by TMHMM2.0 at aa 10-27, 47-69, 94-116, 173-195 and 205-227 637910007516 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910007517 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 637910007518 HMMPfam hit to PF06192, Cytoplasmic chaperone TorD, score 1.2e-51 637910007519 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 637910007520 HMMPfam hit to PF06649, Protein of unknown function DUF1161, score 3.8e-39 637910007521 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 637910007522 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637910007523 Coenzyme A binding pocket [chemical binding]; other site 637910007524 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 3.2e-20 637910007525 hypothetical protein; Provisional; Region: PRK13659 637910007526 HMMPfam hit to PF06932, Protein of unknown function DUF1283, score 5.9e-67 637910007527 pseudogene, N-terminus missing, fragment 637910007528 metabolite-proton symporter; Region: 2A0106; TIGR00883 637910007529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910007530 putative substrate translocation pore; other site 637910007531 9 transmembrane helices predicted for ROD14821 by TMHMM2.0 at aa 27-49, 61-83, 131-153, 160-182, 257-276, 283-302, 312-334, 355-372 and 376-398 637910007532 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 3.3e-24 637910007533 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 637910007534 Glucuronate isomerase; Region: UxaC; pfam02614 637910007535 HMMPfam hit to PF02614, Glucuronate isomerase, score 1.1e-200 637910007536 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 637910007537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910007538 putative substrate translocation pore; other site 637910007539 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 7.7e-14 637910007540 11 transmembrane helices predicted for ROD14841 by TMHMM2.0 at aa 21-43, 53-75, 88-105, 110-132, 153-175, 179-201, 253-275, 285-307, 314-336, 395-414 and 427-449 637910007541 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 637910007542 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 637910007543 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 637910007544 HMMPfam hit to PF01232, Mannitol dehydrogenase rossman, N-terminal, score 1.8e-93 637910007545 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007546 HMMPfam hit to PF08125, Mannitol dehydrogenase, C-terminal, score 5.1e-134 637910007547 PS00974 Mannitol dehydrogenases signature. 637910007548 YdfZ protein; Region: YdfZ; pfam14001 637910007549 Transcriptional regulators [Transcription]; Region: GntR; COG1802 637910007550 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910007551 DNA-binding site [nucleotide binding]; DNA binding site 637910007552 FCD domain; Region: FCD; pfam07729 637910007553 HMMPfam hit to PF07729, GntR, C-terminal, score 7e-15 637910007554 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 1.6e-21 637910007555 PS00043 Bacterial regulatory proteins, gntR family signature. 637910007556 malonic semialdehyde reductase; Provisional; Region: PRK10538 637910007557 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 637910007558 putative NAD(P) binding site [chemical binding]; other site 637910007559 homodimer interface [polypeptide binding]; other site 637910007560 homotetramer interface [polypeptide binding]; other site 637910007561 active site 637910007562 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 2e-32 637910007563 PS00061 Short-chain dehydrogenases/reductases family signature. 637910007564 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 637910007565 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 637910007566 active site 637910007567 Zn binding site [ion binding]; other site 637910007568 HMMPfam hit to PF01432, Peptidase M3A and M3B, thimet/oligopeptidase F, score 2e-181 637910007569 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 637910007570 2 transmembrane helices predicted for ROD14901 by TMHMM2.0 at aa 13-35 and 64-83 637910007571 Competence-damaged protein; Region: CinA; cl00666 637910007572 HMMPfam hit to PF02464, CinA, C-terminal, score 2.7e-68 637910007573 Predicted membrane protein [Function unknown]; Region: COG2323 637910007574 HMMPfam hit to PF04239, Protein of unknown function DUF421, score 5e-10 637910007575 2 transmembrane helices predicted for ROD14931 by TMHMM2.0 at aa 7-26 and 53-75 637910007576 1 transmembrane helix predicted for ROD14941 by TMHMM2.0 at aa 30-52 637910007577 hypothetical protein; Provisional; Region: PRK10053 637910007578 HMMPfam hit to PF04076, Conserved hypothetical protein CHP00156, score 1.5e-64 637910007579 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 637910007580 substrate binding site [chemical binding]; other site 637910007581 THF binding site; other site 637910007582 zinc-binding site [ion binding]; other site 637910007583 HMMPfam hit to PF01717, Methionine synthase, vitamin-B12 independent, score 9.1e-05 637910007584 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 637910007585 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 637910007586 putative ligand binding site [chemical binding]; other site 637910007587 PS00430 TonB-dependent receptor proteins signature 1. 637910007588 HEAT repeats; Region: HEAT_2; pfam13646 637910007589 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 637910007590 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637910007591 TM-ABC transporter signature motif; other site 637910007592 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 4.9e-41 637910007593 7 transmembrane helices predicted for ROD15001 by TMHMM2.0 at aa 237-259, 289-311, 324-346, 370-392, 424-446, 461-483 and 492-509 637910007594 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 637910007595 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 637910007596 TM-ABC transporter signature motif; other site 637910007597 11 transmembrane helices predicted for ROD15011 by TMHMM2.0 at aa 15-37, 44-66, 70-92, 99-121, 126-148, 155-174, 178-197, 204-226, 257-279, 292-314 and 329-351 637910007598 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 2.9e-36 637910007599 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 637910007600 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 637910007601 Walker A/P-loop; other site 637910007602 ATP binding site [chemical binding]; other site 637910007603 Q-loop/lid; other site 637910007604 ABC transporter signature motif; other site 637910007605 Walker B; other site 637910007606 D-loop; other site 637910007607 H-loop/switch region; other site 637910007608 HMMPfam hit to PF00005, ABC transporter related, score 1.4e-45 637910007609 PS00017 ATP/GTP-binding site motif A (P-loop). 637910007610 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 637910007611 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 637910007612 Walker A/P-loop; other site 637910007613 ATP binding site [chemical binding]; other site 637910007614 Q-loop/lid; other site 637910007615 ABC transporter signature motif; other site 637910007616 Walker B; other site 637910007617 D-loop; other site 637910007618 H-loop/switch region; other site 637910007619 HMMPfam hit to PF00005, ABC transporter related, score 9.2e-45 637910007620 PS00017 ATP/GTP-binding site motif A (P-loop). 637910007621 putative transporter; Provisional; Region: PRK10054 637910007622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910007623 putative substrate translocation pore; other site 637910007624 12 transmembrane helices predicted for ROD15041 by TMHMM2.0 at aa 12-34, 44-66, 75-94, 99-121, 133-155, 165-187, 208-230, 245-264, 276-295, 300-322, 335-357 and 362-381 637910007625 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.1e-35 637910007626 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 637910007627 EamA-like transporter family; Region: EamA; pfam00892 637910007628 10 transmembrane helices predicted for ROD15051 by TMHMM2.0 at aa 7-29, 33-51, 58-80, 90-109, 116-135, 140-162, 174-196, 211-233, 246-263 and 267-289 637910007629 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 2.1e-12 637910007630 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 2e-16 637910007631 MarB protein; Region: MarB; pfam13999 637910007632 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 637910007633 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910007634 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910007635 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 5.6e-10 637910007636 PS00041 Bacterial regulatory proteins, araC family signature. 637910007637 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.9e-13 637910007638 Predicted helix-turn-helix motif with score 1423.000, SD 4.03 at aa 26-47, sequence LSLEKVSERSGYSKWHLQRMFK 637910007639 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 637910007640 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 637910007641 PS00190 Cytochrome c family heme-binding site signature. 637910007642 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 1.5e-27 637910007643 PS01117 Bacterial regulatory proteins, marR family signature. 637910007644 inner membrane protein; Provisional; Region: PRK10995 637910007645 HMMPfam hit to PF01914, Multiple antibiotic resistance (MarC)-related proteins, score 2.7e-91 637910007646 6 transmembrane helices predicted for ROD15091 by TMHMM2.0 at aa 10-32, 44-66, 71-93, 117-139, 154-176 and 196-218 637910007647 putative arabinose transporter; Provisional; Region: PRK03545 637910007648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910007649 putative substrate translocation pore; other site 637910007650 12 transmembrane helices predicted for ROD15101 by TMHMM2.0 at aa 12-34, 49-71, 80-99, 109-131, 138-160, 170-189, 210-229, 244-266, 273-295, 299-321, 333-352 and 362-384 637910007651 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 2e-44 637910007652 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007653 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 637910007654 HMMPfam hit to PF02567, Phenazine biosynthesis PhzC/PhzF protein, score 1.1e-50 637910007655 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 637910007656 transmembrane helices; other site 637910007657 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 637910007658 11 transmembrane helices predicted for ROD15121 by TMHMM2.0 at aa 7-28, 48-70, 98-120, 149-171, 180-202, 253-271, 284-306, 310-332, 345-367, 372-394 and 401-423 637910007659 HMMPfam hit to PF03600, Divalent ion symporter, score 0.0047 637910007660 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007661 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 637910007662 BNR repeat-like domain; Region: BNR_2; pfam13088 637910007663 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 4.8 637910007664 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 5.9 637910007665 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 1.5 637910007666 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 3.6 637910007667 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 637910007668 7 transmembrane helices predicted for ROD15141 by TMHMM2.0 at aa 15-37, 50-72, 82-104, 124-146, 151-173, 186-203 and 213-231 637910007669 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 637910007670 HMMPfam hit to PF03741, Integral membrane protein TerC, score 1.7e-28 637910007671 dihydrodipicolinate synthase; Region: dapA; TIGR00674 637910007672 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 637910007673 inhibitor site; inhibition site 637910007674 active site 637910007675 dimer interface [polypeptide binding]; other site 637910007676 catalytic residue [active] 637910007677 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase, score 2e-45 637910007678 PS00666 Dihydrodipicolinate synthetase signature 2. 637910007679 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 637910007680 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 637910007681 active site 637910007682 NAD binding site [chemical binding]; other site 637910007683 metal binding site [ion binding]; metal-binding site 637910007684 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 9e-48 637910007685 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910007686 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910007687 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 637910007688 putative dimerization interface [polypeptide binding]; other site 637910007689 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.7e-51 637910007690 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.4e-18 637910007691 PS00044 Bacterial regulatory proteins, lysR family signature. 637910007692 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 637910007693 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 637910007694 NAD(P) binding site [chemical binding]; other site 637910007695 catalytic residues [active] 637910007696 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 4.9e-160 637910007697 PS00070 Aldehyde dehydrogenases cysteine active site. 637910007698 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 637910007699 glutaminase; Provisional; Region: PRK00971 637910007700 HMMPfam hit to PF04960, Glutaminase, core, score 4.5e-202 637910007701 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 637910007702 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637910007703 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637910007704 metal binding site [ion binding]; metal-binding site 637910007705 active site 637910007706 I-site; other site 637910007707 9 transmembrane helices predicted for ROD15211 by TMHMM2.0 at aa 21-40, 50-69, 72-89, 93-115, 128-150, 172-194, 201-223, 243-265 and 278-300 637910007708 HMMPfam hit to PF00990, GGDEF, score 1.1e-55 637910007709 altronate oxidoreductase; Provisional; Region: PRK03643 637910007710 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 637910007711 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 637910007712 HMMPfam hit to PF01232, Mannitol dehydrogenase rossman, N-terminal, score 9.9e-51 637910007713 HMMPfam hit to PF08125, Mannitol dehydrogenase, C-terminal, score 1.4e-96 637910007714 Predicted membrane protein [Function unknown]; Region: COG3781 637910007715 HMMPfam hit to PF05249, Protein of unknown function UPF0187, score 5.2e-175 637910007716 3 transmembrane helices predicted for ROD15231 by TMHMM2.0 at aa 28-47, 52-74 and 218-240 637910007717 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 637910007718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910007719 S-adenosylmethionine binding site [chemical binding]; other site 637910007720 HMMPfam hit to PF08241, Methyltransferase type 11, score 4.6e-16 637910007721 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 637910007722 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 637910007723 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637910007724 catalytic residue [active] 637910007725 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 8.3e-30 637910007726 PS00237 G-protein coupled receptors signature. 637910007727 2 transmembrane helices predicted for ROD15261 by TMHMM2.0 at aa 12-29 and 39-61 637910007728 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 637910007729 Na binding site [ion binding]; other site 637910007730 13 transmembrane helices predicted for ROD15271 by TMHMM2.0 at aa 6-28, 33-55, 75-97, 129-151, 161-183, 195-217, 237-259, 272-294, 329-351, 372-389, 393-415, 427-449 and 459-481 637910007731 HMMPfam hit to PF00474, Na+/solute symporter, score 2.2e-40 637910007732 PS00457 Sodium:solute symporter family signature 2. 637910007733 Predicted transcriptional regulators [Transcription]; Region: COG1725 637910007734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910007735 DNA-binding site [nucleotide binding]; DNA binding site 637910007736 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 3.6e-12 637910007737 Predicted helix-turn-helix motif with score 1017.000, SD 2.65 at aa 37-58, sequence PSVRALSKTLGVAQLTVSHAYN 637910007738 Creatinine amidohydrolase; Region: Creatininase; pfam02633 637910007739 HMMPfam hit to PF02633, Creatininase, score 4.2e-09 637910007740 Homeodomain-like domain; Region: HTH_32; pfam13565 637910007741 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 637910007742 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637910007743 putative DNA binding site [nucleotide binding]; other site 637910007744 putative Zn2+ binding site [ion binding]; other site 637910007745 HipA-like N-terminal domain; Region: HipA_N; pfam07805 637910007746 HipA-like C-terminal domain; Region: HipA_C; pfam07804 637910007747 HMMPfam hit to PF07804, HipA-like, C-terminal, score 1.5e-07 637910007748 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007749 HMMPfam hit to PF07805, HipA-like, N-terminal, score 3.8e-15 637910007750 HMMPfam hit to PF01022, Bacterial regulatory protein, ArsR, score 7.3e-06 637910007751 Predicted helix-turn-helix motif with score 2278.000, SD 6.95 at aa 17-38, sequence TTARQLADIMGISQPTVSRELK 637910007752 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 637910007753 HMMPfam hit to PF04076, Conserved hypothetical protein CHP00156, score 1.5e-12 637910007754 1 transmembrane helix predicted for ROD15341 by TMHMM2.0 at aa 7-29 637910007755 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 637910007756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 637910007757 HMMPfam hit to PF02638, Protein of unknown function DUF187, score 1.4e-208 637910007758 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007759 transcriptional regulator MirA; Provisional; Region: PRK15043 637910007760 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 637910007761 DNA binding residues [nucleotide binding] 637910007762 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 2.9e-11 637910007763 PS00552 Bacterial regulatory proteins, merR family signature. 637910007764 Predicted helix-turn-helix motif with score 1777.000, SD 5.24 at aa 12-33, sequence YSIGDVSERCGINPVTLRAWQR 637910007765 Sensors of blue-light using FAD; Region: BLUF; pfam04940 637910007766 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637910007767 HMMPfam hit to PF00563, EAL, score 2.8e-55 637910007768 HMMPfam hit to PF04940, BLUF, score 4e-38 637910007769 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 637910007770 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 637910007771 HMMPfam hit to PF06884, Protein of unknown function DUF1264, score 6.9e-135 637910007772 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 637910007773 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 637910007774 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 637910007775 active site 637910007776 catalytic site [active] 637910007777 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 3.5e-13 637910007778 HMMPfam hit to PF02922, Glycoside hydrolase, family 13, N-terminal, score 4.7e-31 637910007779 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 637910007780 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 637910007781 active site 637910007782 catalytic site [active] 637910007783 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 9.2e-21 637910007784 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 637910007785 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 637910007786 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 637910007787 catalytic site [active] 637910007788 active site 637910007789 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 637910007790 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 6.7e-05 637910007791 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 9.4e-18 637910007792 HMMPfam hit to PF02922, Glycoside hydrolase, family 13, N-terminal, score 0.0084 637910007793 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 637910007794 heme-binding site [chemical binding]; other site 637910007795 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637910007796 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637910007797 metal binding site [ion binding]; metal-binding site 637910007798 active site 637910007799 I-site; other site 637910007800 HMMPfam hit to PF00990, GGDEF, score 2.4e-70 637910007801 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 637910007802 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637910007803 putative active site [active] 637910007804 heme pocket [chemical binding]; other site 637910007805 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637910007806 putative active site [active] 637910007807 heme pocket [chemical binding]; other site 637910007808 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637910007809 metal binding site [ion binding]; metal-binding site 637910007810 active site 637910007811 I-site; other site 637910007812 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637910007813 HMMPfam hit to PF00989, PAS fold, score 2.6e-12 637910007814 HMMPfam hit to PF00989, PAS fold, score 5.6e-15 637910007815 HMMPfam hit to PF00990, GGDEF, score 4.7e-17 637910007816 HMMPfam hit to PF00563, EAL, score 3.6e-121 637910007817 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910007818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910007819 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 637910007820 putative dimerization interface [polypeptide binding]; other site 637910007821 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.3e-45 637910007822 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 3.6e-20 637910007823 PS00044 Bacterial regulatory proteins, lysR family signature. 637910007824 Predicted helix-turn-helix motif with score 1368.000, SD 3.85 at aa 18-39, sequence LNFAHASERLNISQPALSLTIK 637910007825 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 637910007826 HMMPfam hit to PF01144, Coenzyme A transferase, score 1.4e-91 637910007827 PS01273 CoA transferases signature 1. 637910007828 pseudogene, C-terminus missing, truncated by downstream deletion event 637910007829 HMMPfam hit to PF01144, Coenzyme A transferase, score 3.2e-28 637910007830 pseudogene, N-terminus missing, truncated by upstream deletion event and C-terminal part truncated by frameshift mutation 637910007831 HMMPfam hit to PF03600, Divalent ion symporter, score 9.5e-37 637910007832 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 637910007833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637910007834 NAD(P) binding site [chemical binding]; other site 637910007835 active site 637910007836 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 9.1e-32 637910007837 PS00061 Short-chain dehydrogenases/reductases family signature. 637910007838 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 637910007839 HMMPfam hit to PF02566, OsmC-like protein, score 1.3e-29 637910007840 biofilm-dependent modulation protein; Provisional; Region: PRK11436 637910007841 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 637910007842 HMMPfam hit to PF08136, Ribosomal protein, S22, score 2.1e-31 637910007843 malate dehydrogenase; Provisional; Region: PRK13529 637910007844 Malic enzyme, N-terminal domain; Region: malic; pfam00390 637910007845 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 637910007846 NAD(P) binding site [chemical binding]; other site 637910007847 HMMPfam hit to PF00390, Malic enzyme, N-terminal, score 8.8e-130 637910007848 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007849 PS00331 Malic enzymes signature. 637910007850 HMMPfam hit to PF03949, Malic enzyme, NAD-binding, score 1.4e-142 637910007851 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007852 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 637910007853 HMMPfam hit to PF05015, Plasmid maintenance system killer, score 1.1e-40 637910007854 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 637910007855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637910007856 non-specific DNA binding site [nucleotide binding]; other site 637910007857 salt bridge; other site 637910007858 sequence-specific DNA binding site [nucleotide binding]; other site 637910007859 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 3.1e-10 637910007860 Predicted helix-turn-helix motif with score 1665.000, SD 4.86 at aa 22-43, sequence VSLREFARAMEIAPSTASRLLT 637910007861 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 637910007862 dimer interface [polypeptide binding]; other site 637910007863 substrate binding site [chemical binding]; other site 637910007864 metal binding sites [ion binding]; metal-binding site 637910007865 HMMPfam hit to PF00719, Inorganic pyrophosphatase, score 1.2e-43 637910007866 PS00387 Inorganic pyrophosphatase signature. 637910007867 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 637910007868 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 637910007869 4 transmembrane helices predicted for ROD15601 by TMHMM2.0 at aa 21-43, 53-75, 117-139 and 154-176 637910007870 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 637910007871 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 637910007872 HMMPfam hit to PF09163, Formate dehydrogenase, transmembrane, score 3.6e-21 637910007873 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 2.5e-05 637910007874 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910007875 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 637910007876 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 637910007877 [4Fe-4S] binding site [ion binding]; other site 637910007878 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 637910007879 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 637910007880 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 637910007881 molybdopterin cofactor binding site; other site 637910007882 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 3.1e-15 637910007883 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1.1e-33 637910007884 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 1.6e-22 637910007885 aromatic amino acid exporter; Provisional; Region: PRK11689 637910007886 9 transmembrane helices predicted for ROD15631 by TMHMM2.0 at aa 15-35, 42-64, 74-96, 103-120, 135-157, 164-186, 196-218, 225-247 and 251-270 637910007887 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 1.6e-05 637910007888 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 637910007889 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 637910007890 trimer interface [polypeptide binding]; other site 637910007891 eyelet of channel; other site 637910007892 HMMPfam hit to PF00267, Porin, Gram-negative type, score 8.5e-205 637910007893 PS00576 General diffusion Gram-negative porins signature. 637910007894 Uncharacterized conserved protein [Function unknown]; Region: COG3791 637910007895 HMMPfam hit to PF04828, Glutathione-dependent formaldehyde-activating, GFA, score 1.1e-14 637910007896 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 637910007897 14 transmembrane helices predicted for ROD15661 by TMHMM2.0 at aa 7-29, 44-66, 73-92, 97-119, 132-154, 158-180, 193-212, 218-240, 261-283, 298-320, 327-344, 354-376, 389-411 and 468-490 637910007898 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 5.1e-45 637910007899 TetR family transcriptional regulator; Provisional; Region: PRK14996 637910007900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637910007901 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 4.2e-12 637910007902 Predicted helix-turn-helix motif with score 986.000, SD 2.55 at aa 29-50, sequence MTVRRIASEAKVATGQVHHHFA 637910007903 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 637910007904 12 transmembrane helices predicted for ROD15681 by TMHMM2.0 at aa 36-58, 73-95, 102-120, 130-152, 172-194, 214-233, 254-276, 286-308, 313-335, 345-367, 401-418 and 433-455 637910007905 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.2e-13 637910007906 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 637910007907 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 637910007908 [4Fe-4S] binding site [ion binding]; other site 637910007909 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 637910007910 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 637910007911 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 637910007912 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 637910007913 molybdopterin cofactor binding site; other site 637910007914 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 637910007915 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1.5e-148 637910007916 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910007917 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 637910007918 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 2.7e-24 637910007919 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 637910007920 PS00190 Cytochrome c family heme-binding site signature. 637910007921 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 637910007922 HMMPfam hit to PF02613, Nitrate reductase, delta subunit, score 9.9e-83 637910007923 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 637910007924 HMMPfam hit to PF02665, Nitrate reductase, gamma subunit, score 2.4e-121 637910007925 5 transmembrane helices predicted for ROD15721 by TMHMM2.0 at aa 5-27, 48-70, 90-112, 128-150 and 185-207 637910007926 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 637910007927 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637910007928 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637910007929 HMMPfam hit to PF03212, Pertactin, score 4.3e-08 637910007930 HMMPfam hit to PF03797, Autotransporter beta-domain, score 5.4e-43 637910007931 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 637910007932 HMMPfam hit to PF00797, N-acetyltransferase, score 9.5e-115 637910007933 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 637910007934 HMMPfam hit to PF01613, Flavin reductase-like, FMN-binding, score 3e-05 637910007935 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 637910007936 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 637910007937 C-terminal domain interface [polypeptide binding]; other site 637910007938 GSH binding site (G-site) [chemical binding]; other site 637910007939 dimer interface [polypeptide binding]; other site 637910007940 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 637910007941 dimer interface [polypeptide binding]; other site 637910007942 N-terminal domain interface [polypeptide binding]; other site 637910007943 substrate binding pocket (H-site) [chemical binding]; other site 637910007944 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 637910007945 pseudogene, truncated by frameshift mutation 637910007946 HMMPfam hit to PF07715, TonB-dependent receptor, plug, score 4.9e-24 637910007947 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 1.7e-33 637910007948 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 637910007949 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910007950 DNA-binding site [nucleotide binding]; DNA binding site 637910007951 FCD domain; Region: FCD; pfam07729 637910007952 HMMPfam hit to PF07729, GntR, C-terminal, score 0.0001 637910007953 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 1.2e-13 637910007954 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 637910007955 Prostaglandin dehydrogenases; Region: PGDH; cd05288 637910007956 NAD(P) binding site [chemical binding]; other site 637910007957 substrate binding site [chemical binding]; other site 637910007958 dimer interface [polypeptide binding]; other site 637910007959 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 1.2e-20 637910007960 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637910007961 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637910007962 non-specific DNA binding site [nucleotide binding]; other site 637910007963 salt bridge; other site 637910007964 sequence-specific DNA binding site [nucleotide binding]; other site 637910007965 Cupin domain; Region: Cupin_2; cl17218 637910007966 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 3.5e-17 637910007967 Predicted helix-turn-helix motif with score 2032.000, SD 6.11 at aa 25-46, sequence WSLTELAEKAGVSRAMIHKIER 637910007968 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 637910007969 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637910007970 Coenzyme A binding pocket [chemical binding]; other site 637910007971 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 4e-24 637910007972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 637910007973 HMMPfam hit to PF04657, Protein of unknown function DUF606, score 5.2e-51 637910007974 5 transmembrane helices predicted for ROD15841 by TMHMM2.0 at aa 7-29, 33-55, 68-90, 94-116 and 123-145 637910007975 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 637910007976 Virulence factor SrfB; Region: SrfB; pfam07520 637910007977 HMMPfam hit to PF07520, Predicted virulence protein SrfB, score 0 637910007978 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 637910007979 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 637910007980 2 transmembrane helices predicted for ROD15891 by TMHMM2.0 at aa 29-46 and 56-78 637910007981 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 637910007982 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 637910007983 tetrameric interface [polypeptide binding]; other site 637910007984 NAD binding site [chemical binding]; other site 637910007985 catalytic residues [active] 637910007986 substrate binding site [chemical binding]; other site 637910007987 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 2.4e-224 637910007988 PS00687 Aldehyde dehydrogenases glutamic acid active site. 637910007989 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 637910007990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910007991 dimer interface [polypeptide binding]; other site 637910007992 conserved gate region; other site 637910007993 ABC-ATPase subunit interface; other site 637910007994 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.5e-09 637910007995 6 transmembrane helices predicted for ROD15911 by TMHMM2.0 at aa 12-34, 71-93, 100-122, 132-154, 180-202 and 234-256 637910007996 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910007997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910007998 dimer interface [polypeptide binding]; other site 637910007999 conserved gate region; other site 637910008000 putative PBP binding loops; other site 637910008001 ABC-ATPase subunit interface; other site 637910008002 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 4.1e-10 637910008003 6 transmembrane helices predicted for ROD15921 by TMHMM2.0 at aa 27-49, 89-111, 124-146, 186-208, 232-254 and 283-305 637910008004 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910008005 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008006 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 637910008007 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910008008 Walker A/P-loop; other site 637910008009 ATP binding site [chemical binding]; other site 637910008010 Q-loop/lid; other site 637910008011 ABC transporter signature motif; other site 637910008012 Walker B; other site 637910008013 D-loop; other site 637910008014 H-loop/switch region; other site 637910008015 TOBE domain; Region: TOBE_2; pfam08402 637910008016 HMMPfam hit to PF08402, Transport-associated OB, type 2, score 2.1e-16 637910008017 PS00211 ABC transporters family signature. 637910008018 HMMPfam hit to PF00005, ABC transporter related, score 7.7e-65 637910008019 PS00211 ABC transporters family signature. 637910008020 PS00017 ATP/GTP-binding site motif A (P-loop). 637910008021 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 637910008022 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 637910008023 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 5.5e-23 637910008024 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 637910008025 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910008026 DNA-binding site [nucleotide binding]; DNA binding site 637910008027 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637910008028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910008029 homodimer interface [polypeptide binding]; other site 637910008030 catalytic residue [active] 637910008031 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 1.5e-11 637910008032 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 4.1e-15 637910008033 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 637910008034 Predicted helix-turn-helix motif with score 1139.000, SD 3.07 at aa 98-119, sequence ISQLELAKRIGRPKQEITRLFD 637910008035 HMMPfam hit to PF03681, Protein of unknown function UPF0150, score 1.9e-13 637910008036 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 637910008037 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 637910008038 Peptidase family U32; Region: Peptidase_U32; pfam01136 637910008039 Collagenase; Region: DUF3656; pfam12392 637910008040 HMMPfam hit to PF01136, Peptidase U32, score 2.4e-72 637910008041 PS01276 Peptidase family U32 signature. 637910008042 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 637910008043 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637910008044 non-specific DNA binding site [nucleotide binding]; other site 637910008045 salt bridge; other site 637910008046 sequence-specific DNA binding site [nucleotide binding]; other site 637910008047 Cupin domain; Region: Cupin_2; pfam07883 637910008048 HMMPfam hit to PF07883, Cupin 2, conserved barrel, score 6.6e-08 637910008049 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 9.1e-16 637910008050 Predicted helix-turn-helix motif with score 1598.000, SD 4.63 at aa 21-42, sequence WSLSRLAEATGVSKAMLGQIER 637910008051 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 637910008052 benzoate transporter; Region: benE; TIGR00843 637910008053 HMMPfam hit to PF03594, Benzoate membrane transport protein, score 2.6e-189 637910008054 11 transmembrane helices predicted for ROD16001 by TMHMM2.0 at aa 11-33, 43-65, 70-89, 94-113, 120-142, 157-179, 192-214, 245-267, 288-310, 315-337 and 350-372 637910008055 PS00041 Bacterial regulatory proteins, araC family signature. 637910008056 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910008057 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637910008058 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910008059 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.3e-13 637910008060 PS00041 Bacterial regulatory proteins, araC family signature. 637910008061 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 7.9e-08 637910008062 Predicted helix-turn-helix motif with score 1224.000, SD 3.36 at aa 204-225, sequence MTLADLAREAALSEFHFARMFR 637910008063 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 637910008064 10 transmembrane helices predicted for ROD16021 by TMHMM2.0 at aa 2-21, 31-50, 63-85, 90-112, 119-136, 147-169, 182-199, 209-231, 238-260 and 264-286 637910008065 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 3e-09 637910008066 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 2.2e-11 637910008067 HMMPfam hit to PF05684, Protein of unknown function DUF819, score 0.00056 637910008068 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 637910008069 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008070 tellurite resistance protein TehB; Provisional; Region: PRK11207 637910008071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910008072 S-adenosylmethionine binding site [chemical binding]; other site 637910008073 HMMPfam hit to PF03848, Tellurite resistance methyltransferase, TehB, core, score 3.7e-151 637910008074 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 637910008075 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 637910008076 gating phenylalanine in ion channel; other site 637910008077 8 transmembrane helices predicted for ROD16051 by TMHMM2.0 at aa 13-35, 48-70, 82-104, 108-126, 161-183, 198-220, 233-255 and 285-307 637910008078 HMMPfam hit to PF03595, C4-dicarboxylate transporter/malic acid transport protein, score 2.6e-82 637910008079 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008080 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008081 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 637910008082 putative trimer interface [polypeptide binding]; other site 637910008083 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 637910008084 putative trimer interface [polypeptide binding]; other site 637910008085 putative CoA binding site [chemical binding]; other site 637910008086 putative CoA binding site [chemical binding]; other site 637910008087 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 637910008088 putative trimer interface [polypeptide binding]; other site 637910008089 putative CoA binding site [chemical binding]; other site 637910008090 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 37 637910008091 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 57 637910008092 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 57 637910008093 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 23 637910008094 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 96 637910008095 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 17 637910008096 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 37 637910008097 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 637910008098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637910008099 Coenzyme A binding pocket [chemical binding]; other site 637910008100 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.8e-13 637910008101 hypothetical protein; Provisional; Region: PRK11415 637910008102 HMMPfam hit to PF04325, Protein of unknown function DUF465, score 1.3e-07 637910008103 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 637910008104 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 637910008105 HMMPfam hit to PF04349, Glucan biosynthesis, periplasmic, MdoG C-terminal, score 6.8e-167 637910008106 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008107 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 637910008108 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 637910008109 substrate binding pocket [chemical binding]; other site 637910008110 catalytic triad [active] 637910008111 HMMPfam hit to PF00135, Carboxylesterase, type B, score 2.9e-102 637910008112 PS00122 Carboxylesterases type-B serine active site. 637910008113 PS00941 Carboxylesterases type-B signature 2. 637910008114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 637910008115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 637910008116 PS00294 Prenyl group binding site (CAAX box). 637910008117 HMMPfam hit to PF07063, Protein of unknown function DUF1338, score 1.1e-73 637910008118 PS00237 G-protein coupled receptors signature. 637910008119 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 637910008120 heterodimer interface [polypeptide binding]; other site 637910008121 multimer interface [polypeptide binding]; other site 637910008122 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 637910008123 active site 637910008124 HMMPfam hit to PF00775, Intradiol ring-cleavage dioxygenase, C-terminal, score 8.8e-68 637910008125 PS00083 Intradiol ring-cleavage dioxygenases signature. 637910008126 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 637910008127 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 637910008128 heterodimer interface [polypeptide binding]; other site 637910008129 active site 637910008130 HMMPfam hit to PF00775, Intradiol ring-cleavage dioxygenase, C-terminal, score 4.4e-08 637910008131 PS00083 Intradiol ring-cleavage dioxygenases signature. 637910008132 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 637910008133 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910008134 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637910008135 dimerization interface [polypeptide binding]; other site 637910008136 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 4.4e-18 637910008137 Predicted helix-turn-helix motif with score 1622.000, SD 4.71 at aa 26-47, sequence GTLGRAAETLNLSQPALSKTLN 637910008138 PS00044 Bacterial regulatory proteins, lysR family signature. 637910008139 HMMPfam hit to PF03466, LysR, substrate-binding, score 7.2e-36 637910008140 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 637910008141 dimer interface [polypeptide binding]; other site 637910008142 ligand binding site [chemical binding]; other site 637910008143 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637910008144 dimerization interface [polypeptide binding]; other site 637910008145 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637910008146 dimer interface [polypeptide binding]; other site 637910008147 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 637910008148 putative CheW interface [polypeptide binding]; other site 637910008149 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 5e-113 637910008150 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 3.8e-15 637910008151 2 transmembrane helices predicted for ROD16161 by TMHMM2.0 at aa 25-47 and 203-225 637910008152 HMMPfam hit to PF02203, Ligand binding Tar, score 3.3e-30 637910008153 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 637910008154 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 637910008155 substrate binding site [chemical binding]; other site 637910008156 catalytic Zn binding site [ion binding]; other site 637910008157 NAD binding site [chemical binding]; other site 637910008158 structural Zn binding site [ion binding]; other site 637910008159 dimer interface [polypeptide binding]; other site 637910008160 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 1.4e-34 637910008161 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 5.1e-39 637910008162 PS00059 Zinc-containing alcohol dehydrogenases signature. 637910008163 5 transmembrane helices predicted for ROD16181 by TMHMM2.0 at aa 12-34, 54-76, 88-110, 120-142 and 155-177 637910008164 pseudogene, truncated by frameshift mutation 637910008165 cytochrome b561; Provisional; Region: PRK11513 637910008166 HMMPfam hit to PF01292, Cytochrome B561, bacterial, score 6.5e-64 637910008167 5 transmembrane helices predicted for ROD16211 by TMHMM2.0 at aa 10-27, 40-62, 82-104, 111-133 and 143-162 637910008168 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 637910008169 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 637910008170 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 637910008171 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, score 1.5e-85 637910008172 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 637910008173 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, score 3.7e-92 637910008174 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 637910008175 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 637910008176 NAD binding site [chemical binding]; other site 637910008177 catalytic residues [active] 637910008178 substrate binding site [chemical binding]; other site 637910008179 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 6.5e-228 637910008180 PS00070 Aldehyde dehydrogenases cysteine active site. 637910008181 PS00687 Aldehyde dehydrogenases glutamic acid active site. 637910008182 Uncharacterized conserved protein [Function unknown]; Region: COG1434 637910008183 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 637910008184 putative active site [active] 637910008185 HMMPfam hit to PF02698, Protein of unknown function DUF218, score 5.9e-25 637910008186 metabolite-proton symporter; Region: 2A0106; TIGR00883 637910008187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910008188 putative substrate translocation pore; other site 637910008189 12 transmembrane helices predicted for ROD16251 by TMHMM2.0 at aa 20-42, 57-79, 91-113, 123-145, 154-176, 186-208, 243-265, 280-302, 309-326, 336-358, 370-392 and 402-424 637910008190 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 6.5e-24 637910008191 PS00217 Sugar transport proteins signature 2. 637910008192 PS00024 Hemopexin domain signature. 637910008193 PS00216 Sugar transport proteins signature 1. 637910008194 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 637910008195 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637910008196 ATP binding site [chemical binding]; other site 637910008197 putative Mg++ binding site [ion binding]; other site 637910008198 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637910008199 nucleotide binding region [chemical binding]; other site 637910008200 ATP-binding site [chemical binding]; other site 637910008201 Helicase associated domain (HA2); Region: HA2; pfam04408 637910008202 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 637910008203 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 637910008204 HMMPfam hit to PF07717, Region of unknown function DUF1605, score 2.3e-21 637910008205 HMMPfam hit to PF04408, Helicase-associated region, score 2.1e-28 637910008206 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 1.2e-13 637910008207 PS00017 ATP/GTP-binding site motif A (P-loop). 637910008208 azoreductase; Reviewed; Region: PRK00170 637910008209 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637910008210 HMMPfam hit to PF02525, Flavodoxin-like fold, score 1.1e-60 637910008211 Uncharacterized conserved protein [Function unknown]; Region: COG3791 637910008212 HMMPfam hit to PF04828, Glutathione-dependent formaldehyde-activating, GFA, score 1.9e-26 637910008213 3 transmembrane helices predicted for ROD16301 by TMHMM2.0 at aa 23-45, 47-69 and 117-134 637910008214 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008215 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 637910008216 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 637910008217 active site 637910008218 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 637910008219 active site 637910008220 catalytic residues [active] 637910008221 HMMPfam hit to PF00782, Protein-tyrosine phosphatase, dual specificity, score 1.1e-12 637910008222 PS00383 Tyrosine specific protein phosphatases active site. 637910008223 5 transmembrane helices predicted for ROD16311 by TMHMM2.0 at aa 12-34, 49-71, 83-105, 175-197 and 218-240 637910008224 HMMPfam hit to PF01569, Phosphatidic acid phosphatase type 2-like, score 1.2e-07 637910008225 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008226 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 637910008227 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 637910008228 Putative methyltransferase; Region: Methyltransf_20; pfam12147 637910008229 HMMPfam hit to PF00561, Alpha/beta hydrolase fold-1, score 0.00055 637910008230 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 637910008231 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 637910008232 putative acyl-acceptor binding pocket; other site 637910008233 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 1.1e-22 637910008234 1 transmembrane helix predicted for ROD16331 by TMHMM2.0 at aa 7-24 637910008235 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 637910008236 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 637910008237 HMMPfam hit to PF01148, Phosphatidate cytidylyltransferase, score 1.7e-82 637910008238 PS01315 Phosphatidate cytidylyltransferase signature. 637910008239 8 transmembrane helices predicted for ROD16341 by TMHMM2.0 at aa 7-29, 44-69, 89-106, 110-132, 145-167, 172-194, 213-235 and 239-261 637910008240 PS00017 ATP/GTP-binding site motif A (P-loop). 637910008241 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 637910008242 PS00237 G-protein coupled receptors signature. 637910008243 3 transmembrane helices predicted for ROD16351 by TMHMM2.0 at aa 27-49, 54-76 and 106-128 637910008244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 637910008245 HMMPfam hit to PF07027, Uncharacterised conserved protein UCP025560, score 5.4e-57 637910008246 hypothetical protein; Provisional; Region: PRK10695 637910008247 1 transmembrane helix predicted for ROD16371 by TMHMM2.0 at aa 7-29 637910008248 hypothetical protein; Provisional; Region: PRK09951 637910008249 HMMPfam hit to PF02586, Protein of unknown function DUF159, score 4.7e-63 637910008250 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 637910008251 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 637910008252 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637910008253 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637910008254 PS00017 ATP/GTP-binding site motif A (P-loop). 637910008255 HMMPfam hit to PF03797, Autotransporter beta-domain, score 1e-35 637910008256 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 637910008257 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 637910008258 putative ligand binding site [chemical binding]; other site 637910008259 putative NAD binding site [chemical binding]; other site 637910008260 catalytic site [active] 637910008261 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region, score 1.9e-37 637910008262 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, score 2.4e-72 637910008263 PS00017 ATP/GTP-binding site motif A (P-loop). 637910008264 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 637910008265 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 637910008266 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 637910008267 heat-inducible protein; Provisional; Region: PRK10449 637910008268 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008269 HMMPfam hit to PF03724, Protein of unknown function DUF306, Meta and HslJ, score 5.8e-31 637910008270 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008271 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 637910008272 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 637910008273 dimer interface [polypeptide binding]; other site 637910008274 PYR/PP interface [polypeptide binding]; other site 637910008275 TPP binding site [chemical binding]; other site 637910008276 substrate binding site [chemical binding]; other site 637910008277 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 637910008278 Domain of unknown function; Region: EKR; smart00890 637910008279 4Fe-4S binding domain; Region: Fer4_6; pfam12837 637910008280 4Fe-4S binding domain; Region: Fer4; pfam00037 637910008281 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 637910008282 TPP-binding site [chemical binding]; other site 637910008283 dimer interface [polypeptide binding]; other site 637910008284 HMMPfam hit to PF01855, Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal, score 3.8e-120 637910008285 HMMPfam hit to PF01558, Pyruvate ferredoxin/flavodoxin oxidoreductase, score 1e-81 637910008286 PS00024 Hemopexin domain signature. 637910008287 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 6.1e-06 637910008288 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910008289 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 7.9e-05 637910008290 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910008291 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-terminal TPP-binding, score 4.3e-11 637910008292 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 637910008293 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 637910008294 trimer interface [polypeptide binding]; other site 637910008295 eyelet of channel; other site 637910008296 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 637910008297 HMMPfam hit to PF00267, Porin, Gram-negative type, score 2.4e-218 637910008298 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 637910008299 Ligand Binding Site [chemical binding]; other site 637910008300 HMMPfam hit to PF00582, UspA, score 3e-20 637910008301 lambdoid prophage remnant.; CRPr17 637910008302 NFkB-p65-degrading zinc protease; Region: Peptidase_M85; pfam13678 637910008303 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 637910008304 pseudogene, truncated by frameshift mutation and internal deletion 637910008305 pseudogene, N-terminus missing, fragment 637910008306 HMMPfam hit to PF06820, prophage tail fibre, C-terminal, score 1.6e-34 637910008307 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 637910008308 HMMPfam hit to PF06416, Protein of unknown function DUF1076, score 9.2e-49 637910008309 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910008310 Transposase; Region: HTH_Tnp_1; pfam01527 637910008311 HMMPfam hit to PF01527, Transposase IS3/IS911, score 5.2e-23 637910008312 Predicted helix-turn-helix motif with score 1681.000, SD 4.91 at aa 23-44, sequence YSVAEVSDRLGVSAHSLYKWLR 637910008313 putative transposase OrfB; Reviewed; Region: PHA02517 637910008314 HTH-like domain; Region: HTH_21; pfam13276 637910008315 Integrase core domain; Region: rve; pfam00665 637910008316 Integrase core domain; Region: rve_3; pfam13683 637910008317 HMMPfam hit to PF00665, Integrase, catalytic core, score 1.3e-45 637910008318 PS00501 Signal peptidases I serine active site. 637910008319 pseudogene, N-terminal missing, truncated by ISEc14 insertion 637910008320 pseudogene, C-terminus missing, fragment 637910008321 HMMPfam hit to PF00665, Integrase, catalytic core, score 2.7e-07 637910008322 pseudogene, fragmented by multiple frameshift mutations 637910008323 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 1.8e-11 637910008324 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 637910008325 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 637910008326 Ligand Binding Site [chemical binding]; other site 637910008327 HMMPfam hit to PF01171, PP-loop, score 7.5e-07 637910008328 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 637910008329 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 637910008330 ATP binding site [chemical binding]; other site 637910008331 Mg++ binding site [ion binding]; other site 637910008332 motif III; other site 637910008333 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637910008334 nucleotide binding region [chemical binding]; other site 637910008335 ATP-binding site [chemical binding]; other site 637910008336 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 637910008337 putative RNA binding site [nucleotide binding]; other site 637910008338 HMMPfam hit to PF03880, DbpA, RNA-binding, score 1.8e-32 637910008339 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 2.7e-32 637910008340 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 5.8e-68 637910008341 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 637910008342 PS00017 ATP/GTP-binding site motif A (P-loop). 637910008343 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 637910008344 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 637910008345 Cl binding site [ion binding]; other site 637910008346 oligomer interface [polypeptide binding]; other site 637910008347 HMMPfam hit to PF01544, Mg2+ transporter protein, CorA-like, score 0.00045 637910008348 2 transmembrane helices predicted for ROD16611 by TMHMM2.0 at aa 272-294 and 301-323 637910008349 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637910008350 PAS domain; Region: PAS_9; pfam13426 637910008351 putative active site [active] 637910008352 heme pocket [chemical binding]; other site 637910008353 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637910008354 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637910008355 metal binding site [ion binding]; metal-binding site 637910008356 active site 637910008357 I-site; other site 637910008358 HMMPfam hit to PF08448, PAS fold-4, score 4e-08 637910008359 HMMPfam hit to PF00990, GGDEF, score 1.8e-52 637910008360 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 637910008361 HMMPfam hit to PF02627, Carboxymuconolactone decarboxylase, score 1.7e-31 637910008362 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 637910008363 TAP-like protein; Region: Abhydrolase_4; pfam08386 637910008364 HMMPfam hit to PF00561, Alpha/beta hydrolase fold-1, score 6.5e-16 637910008365 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008366 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 637910008367 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 637910008368 tetramer interface [polypeptide binding]; other site 637910008369 active site 637910008370 HMMPfam hit to PF00206, Fumarate lyase, score 3.5e-54 637910008371 PS00163 Fumarate lyases signature. 637910008372 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 637910008373 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 637910008374 dimer interface [polypeptide binding]; other site 637910008375 active site 637910008376 HMMPfam hit to PF02803, Thiolase, score 1.5e-70 637910008377 PS00099 Thiolases active site. 637910008378 PS00737 Thiolases signature 2. 637910008379 HMMPfam hit to PF00108, Thiolase, score 1.5e-101 637910008380 PS00098 Thiolases acyl-enzyme intermediate signature. 637910008381 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 637910008382 HMMPfam hit to PF01144, Coenzyme A transferase, score 6.4e-56 637910008383 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008384 PS01274 CoA transferases signature 2. 637910008385 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 637910008386 HMMPfam hit to PF01144, Coenzyme A transferase, score 8.2e-85 637910008387 PS01273 CoA transferases signature 1. 637910008388 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 637910008389 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 637910008390 Bacterial transcriptional regulator; Region: IclR; pfam01614 637910008391 HMMPfam hit to PF09339, Transcriptional regulator IclR, N-terminal, score 1.3e-29 637910008392 Predicted helix-turn-helix motif with score 1560.000, SD 4.50 at aa 43-64, sequence LSISQISQKTGIPRAAVRRCLY 637910008393 HMMPfam hit to PF01614, Transcriptional regulator IclR, C-terminal, score 1.2e-41 637910008394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 637910008395 Smr domain; Region: Smr; pfam01713 637910008396 HMMPfam hit to PF01713, Smr protein/MutS2 C-terminal, score 7.6e-27 637910008397 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008398 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 637910008399 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 637910008400 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 637910008401 DNA binding site [nucleotide binding] 637910008402 active site 637910008403 HMMPfam hit to PF02870, Methylguanine DNA methyltransferase, ribonuclease-like, score 1e-18 637910008404 HMMPfam hit to PF01035, Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding, score 6e-58 637910008405 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 637910008406 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 637910008407 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637910008408 ligand binding site [chemical binding]; other site 637910008409 flexible hinge region; other site 637910008410 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 637910008411 putative switch regulator; other site 637910008412 non-specific DNA interactions [nucleotide binding]; other site 637910008413 DNA binding site [nucleotide binding] 637910008414 sequence specific DNA binding site [nucleotide binding]; other site 637910008415 putative cAMP binding site [chemical binding]; other site 637910008416 HMMPfam hit to PF00027, Cyclic nucleotide-binding, score 1.3e-20 637910008417 HMMPfam hit to PF00325, Bacterial regulatory protein, Crp, score 1.5e-16 637910008418 PS00042 Bacterial regulatory proteins, crp family signature. 637910008419 Predicted helix-turn-helix motif with score 1841.000, SD 5.46 at aa 195-216, sequence MTRGDIGNYLGLTVETISRLLG 637910008420 universal stress protein UspE; Provisional; Region: PRK11175 637910008421 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 637910008422 Ligand Binding Site [chemical binding]; other site 637910008423 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 637910008424 Ligand Binding Site [chemical binding]; other site 637910008425 HMMPfam hit to PF00582, UspA, score 4.9e-17 637910008426 HMMPfam hit to PF00582, UspA, score 5.1e-12 637910008427 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 637910008428 2 transmembrane helices predicted for ROD16741 by TMHMM2.0 at aa 13-35 and 60-82 637910008429 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 637910008430 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637910008431 peptide binding site [polypeptide binding]; other site 637910008432 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 3.1e-83 637910008433 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 637910008434 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 637910008435 putative active site [active] 637910008436 Zn binding site [ion binding]; other site 637910008437 HMMPfam hit to PF00246, Peptidase M14, carboxypeptidase A, score 3.1e-25 637910008438 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 637910008439 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 637910008440 active site 637910008441 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008442 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 5e-17 637910008443 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 637910008444 HMMPfam hit to PF02746, Mandelate racemase/muconate lactonizing enzyme, N-terminal, score 3.1e-37 637910008445 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 637910008446 dimer interface [polypeptide binding]; other site 637910008447 catalytic triad [active] 637910008448 peroxidatic and resolving cysteines [active] 637910008449 HMMPfam hit to PF08534, Redoxin, score 9.8e-51 637910008450 PS01265 Tpx family signature. 637910008451 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 637910008452 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 637910008453 putative aromatic amino acid binding site; other site 637910008454 PAS domain; Region: PAS; smart00091 637910008455 putative active site [active] 637910008456 heme pocket [chemical binding]; other site 637910008457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910008458 Walker A motif; other site 637910008459 ATP binding site [chemical binding]; other site 637910008460 Walker B motif; other site 637910008461 arginine finger; other site 637910008462 Predicted helix-turn-helix motif with score 1684.000, SD 4.92 at aa 481-502, sequence PSTRKLAKRLGVSHTAIANKLR 637910008463 PS00688 Sigma-54 interaction domain C-terminal part signature. 637910008464 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 7.9e-115 637910008465 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 637910008466 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 637910008467 HMMPfam hit to PF01842, Amino acid-binding ACT, score 0.00031 637910008468 hypothetical protein; Provisional; Region: PRK05415 637910008469 TIGR01620 family protein; Region: hyp_HI0043 637910008470 HMMPfam hit to PF05128, Conserved hypothetical protein CHP01620, score 1.5e-207 637910008471 3 transmembrane helices predicted for ROD16801 by TMHMM2.0 at aa 69-88, 98-120 and 210-232 637910008472 Predicted ATPase [General function prediction only]; Region: COG3106 637910008473 HMMPfam hit to PF04317, Protein of unknown function DUF463, YcjX-like protein, score 0 637910008474 PS00017 ATP/GTP-binding site motif A (P-loop). 637910008475 Isochorismatase family; Region: Isochorismatase; pfam00857 637910008476 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 637910008477 catalytic triad [active] 637910008478 conserved cis-peptide bond; other site 637910008479 HMMPfam hit to PF00857, Isochorismatase hydrolase, score 2.9e-06 637910008480 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 637910008481 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637910008482 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637910008483 HMMPfam hit to PF03212, Pertactin, score 5.3e-43 637910008484 HMMPfam hit to PF03797, Autotransporter beta-domain, score 4.2e-32 637910008485 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 637910008486 Predicted membrane protein [Function unknown]; Region: COG3326 637910008487 2 transmembrane helices predicted for ROD16871 by TMHMM2.0 at aa 20-42 and 90-112 637910008488 HMMPfam hit to PF06961, Protein of unknown function DUF1294, score 1.6e-32 637910008489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 637910008490 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 637910008491 HMMPfam hit to PF06906, Protein of unknown function DUF1272, score 4.8e-43 637910008492 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637910008493 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910008494 DNA binding site [nucleotide binding] 637910008495 domain linker motif; other site 637910008496 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 637910008497 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 1.1e-12 637910008498 Predicted helix-turn-helix motif with score 2211.000, SD 6.72 at aa 3-24, sequence PTIYDIARVAGVSKSTVSRVLN 637910008499 PS00356 Bacterial regulatory proteins, lacI family signature. 637910008500 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 1.2e-09 637910008501 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 637910008502 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008503 pseudogene, truncated by premature stop codon 637910008504 HMMPfam hit to PF08402, Transport-associated OB, type 2, score 3.3e-09 637910008505 HMMPfam hit to PF00005, ABC transporter related, score 5.6e-55 637910008506 beta-phosphoglucomutase; Region: bPGM; TIGR01990 637910008507 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910008508 motif II; other site 637910008509 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 2.6e-37 637910008510 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 637910008511 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 637910008512 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 637910008513 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 637910008514 HMMPfam hit to PF03633, Glycoside hydrolase, family 65, C-terminal, score 7.1e-10 637910008515 HMMPfam hit to PF03632, Glycoside hydrolase family 65, central catalytic, score 1.1e-204 637910008516 PS00584 pfkB family of carbohydrate kinases signature 2. 637910008517 HMMPfam hit to PF03636, Glycoside hydrolase family 65, N-terminal, score 1e-67 637910008518 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637910008519 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637910008520 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 637910008521 HMMPfam hit to PF02894, Oxidoreductase, C-terminal, score 8.3e-11 637910008522 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 1.1e-44 637910008523 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 637910008524 HMMPfam hit to PF01261, Xylose isomerase-type TIM barrel, score 4.5e-40 637910008525 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637910008526 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 637910008527 putative NAD(P) binding site [chemical binding]; other site 637910008528 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 3.6e-35 637910008529 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637910008530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910008531 dimer interface [polypeptide binding]; other site 637910008532 conserved gate region; other site 637910008533 putative PBP binding loops; other site 637910008534 ABC-ATPase subunit interface; other site 637910008535 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3.2e-15 637910008536 6 transmembrane helices predicted for ROD16971 by TMHMM2.0 at aa 12-34, 78-100, 117-139, 186-208, 215-237 and 242-264 637910008537 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910008538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910008539 dimer interface [polypeptide binding]; other site 637910008540 conserved gate region; other site 637910008541 putative PBP binding loops; other site 637910008542 ABC-ATPase subunit interface; other site 637910008543 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.3e-19 637910008544 6 transmembrane helices predicted for ROD16981 by TMHMM2.0 at aa 13-35, 76-98, 110-127, 164-186, 208-230 and 265-282 637910008545 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910008546 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637910008547 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 637910008548 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 5.5e-34 637910008549 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008550 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 637910008551 sucrose phosphorylase; Provisional; Region: PRK13840 637910008552 active site 637910008553 homodimer interface [polypeptide binding]; other site 637910008554 catalytic site [active] 637910008555 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 637910008556 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 2.6e-08 637910008557 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 637910008558 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 637910008559 phage shock protein C; Region: phageshock_pspC; TIGR02978 637910008560 HMMPfam hit to PF04024, PspC, score 2.8e-29 637910008561 1 transmembrane helix predicted for ROD17021 by TMHMM2.0 at aa 39-61 637910008562 phage shock protein B; Provisional; Region: pspB; PRK09458 637910008563 HMMPfam hit to PF06667, Phage shock B, score 2.1e-47 637910008564 1 transmembrane helix predicted for ROD17031 by TMHMM2.0 at aa 4-26 637910008565 phage shock protein PspA; Provisional; Region: PRK10698 637910008566 HMMPfam hit to PF04012, PspA/IM30, score 1.3e-55 637910008567 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 637910008568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910008569 Walker A motif; other site 637910008570 ATP binding site [chemical binding]; other site 637910008571 Walker B motif; other site 637910008572 arginine finger; other site 637910008573 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 637910008574 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 1.4e-126 637910008575 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 637910008576 PS00688 Sigma-54 interaction domain C-terminal part signature. 637910008577 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 2.9e-07 637910008578 Predicted helix-turn-helix motif with score 1645.000, SD 4.79 at aa 300-321, sequence FNQKRAAELLGLTYHQLRALLK 637910008579 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637910008580 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 637910008581 peptide binding site [polypeptide binding]; other site 637910008582 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 2.6e-71 637910008583 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 637910008584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910008585 dimer interface [polypeptide binding]; other site 637910008586 conserved gate region; other site 637910008587 putative PBP binding loops; other site 637910008588 ABC-ATPase subunit interface; other site 637910008589 5 transmembrane helices predicted for ROD17071 by TMHMM2.0 at aa 9-31, 80-102, 114-136, 251-273 and 286-308 637910008590 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.3e-53 637910008591 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 637910008592 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 637910008593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910008594 putative PBP binding loops; other site 637910008595 dimer interface [polypeptide binding]; other site 637910008596 ABC-ATPase subunit interface; other site 637910008597 5 transmembrane helices predicted for ROD17081 by TMHMM2.0 at aa 30-52, 99-121, 148-170, 201-223 and 261-283 637910008598 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 4.7e-29 637910008599 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 637910008600 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637910008601 Walker A/P-loop; other site 637910008602 ATP binding site [chemical binding]; other site 637910008603 Q-loop/lid; other site 637910008604 ABC transporter signature motif; other site 637910008605 Walker B; other site 637910008606 D-loop; other site 637910008607 H-loop/switch region; other site 637910008608 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637910008609 HMMPfam hit to PF00005, ABC transporter related, score 9.6e-68 637910008610 PS00017 ATP/GTP-binding site motif A (P-loop). 637910008611 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter C-terminal, score 5.7e-23 637910008612 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 637910008613 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637910008614 Walker A/P-loop; other site 637910008615 ATP binding site [chemical binding]; other site 637910008616 Q-loop/lid; other site 637910008617 ABC transporter signature motif; other site 637910008618 Walker B; other site 637910008619 D-loop; other site 637910008620 H-loop/switch region; other site 637910008621 HMMPfam hit to PF00005, ABC transporter related, score 1.7e-63 637910008622 PS00017 ATP/GTP-binding site motif A (P-loop). 637910008623 PS00211 ABC transporters family signature. 637910008624 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 637910008625 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 637910008626 NAD binding site [chemical binding]; other site 637910008627 homotetramer interface [polypeptide binding]; other site 637910008628 homodimer interface [polypeptide binding]; other site 637910008629 substrate binding site [chemical binding]; other site 637910008630 active site 637910008631 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 0.00097 637910008632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 637910008633 exoribonuclease II; Provisional; Region: PRK05054 637910008634 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 637910008635 RNB domain; Region: RNB; pfam00773 637910008636 S1 RNA binding domain; Region: S1; pfam00575 637910008637 HMMPfam hit to PF08206, Ribonuclease B, OB region N-terminal, score 5.2e-25 637910008638 HMMPfam hit to PF00773, Ribonuclease II and R, score 2.9e-130 637910008639 PS01175 Ribonuclease II family signature. 637910008640 HMMPfam hit to PF00575, S1, RNA binding, score 2.4e-10 637910008641 RNase II stability modulator; Provisional; Region: PRK10060 637910008642 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637910008643 putative active site [active] 637910008644 heme pocket [chemical binding]; other site 637910008645 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637910008646 metal binding site [ion binding]; metal-binding site 637910008647 active site 637910008648 I-site; other site 637910008649 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637910008650 HMMPfam hit to PF00989, PAS fold, score 9.1e-10 637910008651 HMMPfam hit to PF00990, GGDEF, score 2.8e-63 637910008652 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008653 HMMPfam hit to PF00563, EAL, score 4.7e-125 637910008654 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637910008655 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 637910008656 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637910008657 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 1.2e-16 637910008658 Predicted helix-turn-helix motif with score 1900.000, SD 5.66 at aa 18-39, sequence MSVSELAKITGVSEVTIRQDLN 637910008659 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 7.3e-36 637910008660 lipoprotein; Provisional; Region: PRK10540 637910008661 Predicted helix-turn-helix motif with score 1158.000, SD 3.13 at aa 8-29, sequence MTAAVLAITLAMSLSACSNWSK 637910008662 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008663 translation initiation factor Sui1; Validated; Region: PRK06824 637910008664 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 637910008665 putative rRNA binding site [nucleotide binding]; other site 637910008666 HMMPfam hit to PF01253, Translation initiation factor SUI1, score 2e-33 637910008667 PS01118 Translation initiation factor SUI1 signature. 637910008668 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 637910008669 active site 637910008670 dimer interface [polypeptide binding]; other site 637910008671 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase, core, score 5.1e-91 637910008672 PS00156 Orotidine 5'-phosphate decarboxylase active site. 637910008673 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 637910008674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 637910008675 TPR motif; other site 637910008676 binding surface 637910008677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 637910008678 binding surface 637910008679 TPR motif; other site 637910008680 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637910008681 TPR motif; other site 637910008682 binding surface 637910008683 HMMPfam hit to PF07719, Tetratricopeptide TPR2, score 0.00093 637910008684 Predicted membrane protein [Function unknown]; Region: COG3771 637910008685 HMMPfam hit to PF06305, Protein of unknown function DUF1049, score 9.3e-57 637910008686 2 transmembrane helices predicted for ROD17211 by TMHMM2.0 at aa 5-23 and 43-65 637910008687 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 637910008688 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 637910008689 active site 637910008690 HMMPfam hit to PF01569, Phosphatidic acid phosphatase type 2-like, score 4.8e-27 637910008691 6 transmembrane helices predicted for ROD17221 by TMHMM2.0 at aa 12-29, 49-68, 75-92, 157-179, 186-208 and 212-229 637910008692 PS00027 'Homeobox' domain signature. 637910008693 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 637910008694 dimerization interface [polypeptide binding]; other site 637910008695 active site 637910008696 HMMPfam hit to PF00925, GTP cyclohydrolase II, score 8.2e-121 637910008697 aconitate hydratase; Validated; Region: PRK09277 637910008698 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 637910008699 substrate binding site [chemical binding]; other site 637910008700 ligand binding site [chemical binding]; other site 637910008701 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 637910008702 substrate binding site [chemical binding]; other site 637910008703 HMMPfam hit to PF00694, Aconitase A/isopropylmalate dehydratase small subunit, swivel, score 6.1e-66 637910008704 HMMPfam hit to PF00330, Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, score 3.5e-283 637910008705 PS01244 Aconitase family signature 2. 637910008706 PS00450 Aconitase family signature 1. 637910008707 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008708 1 transmembrane helix predicted for ROD17271 by TMHMM2.0 at aa 30-52 637910008709 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 637910008710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910008711 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 637910008712 substrate binding site [chemical binding]; other site 637910008713 putative dimerization interface [polypeptide binding]; other site 637910008714 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.1e-45 637910008715 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 637910008716 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 3.3e-15 637910008717 PS00044 Bacterial regulatory proteins, lysR family signature. 637910008718 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 637910008719 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 637910008720 active site 637910008721 interdomain interaction site; other site 637910008722 putative metal-binding site [ion binding]; other site 637910008723 nucleotide binding site [chemical binding]; other site 637910008724 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 637910008725 domain I; other site 637910008726 DNA binding groove [nucleotide binding] 637910008727 phosphate binding site [ion binding]; other site 637910008728 domain II; other site 637910008729 domain III; other site 637910008730 nucleotide binding site [chemical binding]; other site 637910008731 catalytic site [active] 637910008732 domain IV; other site 637910008733 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 637910008734 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 637910008735 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 637910008736 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 637910008737 HMMPfam hit to PF08272, DNA topoisomerase I, zinc ribbon-like, bacterial-type, score 5.1e-22 637910008738 HMMPfam hit to PF08272, DNA topoisomerase I, zinc ribbon-like, bacterial-type, score 1.1e-15 637910008739 HMMPfam hit to PF01396, DNA topoisomerase, type IA, zn finger, score 1.1e-13 637910008740 HMMPfam hit to PF01396, DNA topoisomerase, type IA, zn finger, score 0.00056 637910008741 HMMPfam hit to PF01131, DNA topoisomerase, type IA, central, score 1.9e-199 637910008742 PS00396 Prokaryotic DNA topoisomerase I active site. 637910008743 HMMPfam hit to PF01751, TOPRIM, score 3.9e-39 637910008744 hypothetical protein; Provisional; Region: PRK11037 637910008745 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 637910008746 putative inner membrane peptidase; Provisional; Region: PRK11778 637910008747 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 637910008748 tandem repeat interface [polypeptide binding]; other site 637910008749 oligomer interface [polypeptide binding]; other site 637910008750 active site residues [active] 637910008751 HMMPfam hit to PF01343, Peptidase S49, score 2.7e-62 637910008752 2 transmembrane helices predicted for ROD17321 by TMHMM2.0 at aa 10-32 and 189-206 637910008753 HMMPfam hit to PF08496, Peptidase S49, N-terminal proteobacteria, score 4.6e-91 637910008754 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 637910008755 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 637910008756 NADP binding site [chemical binding]; other site 637910008757 homodimer interface [polypeptide binding]; other site 637910008758 active site 637910008759 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 5.5e-32 637910008760 PS00061 Short-chain dehydrogenases/reductases family signature. 637910008761 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 637910008762 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 637910008763 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 637910008764 homodimer interface [polypeptide binding]; other site 637910008765 Walker A motif; other site 637910008766 ATP binding site [chemical binding]; other site 637910008767 hydroxycobalamin binding site [chemical binding]; other site 637910008768 Walker B motif; other site 637910008769 HMMPfam hit to PF02572, Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR, score 1e-129 637910008770 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 637910008771 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637910008772 RNA binding surface [nucleotide binding]; other site 637910008773 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 637910008774 probable active site [active] 637910008775 HMMPfam hit to PF00849, Pseudouridine synthase, score 1.3e-12 637910008776 PS01149 Rsu family of pseudouridine synthase signature. 637910008777 HMMPfam hit to PF01479, RNA-binding S4, score 2.6e-08 637910008778 hypothetical protein; Provisional; Region: PRK11630 637910008779 HMMPfam hit to PF01300, SUA5/yciO/yrdC, N-terminal, score 3.1e-80 637910008780 PS01147 SUA5/yciO/yrdC family signature. 637910008781 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 637910008782 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 637910008783 active site 637910008784 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 637910008785 HMMPfam hit to PF02811, PHP, C-terminal, score 1.1e-40 637910008786 HMMPfam hit to PF08255, Leader peptide, tryptophan-operon, score 8.6e-06 637910008787 anthranilate synthase component I; Provisional; Region: PRK13564 637910008788 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 637910008789 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 637910008790 HMMPfam hit to PF04715, Anthranilate synthase component I, N-terminal, score 6e-28 637910008791 HMMPfam hit to PF00425, Chorismate binding, C-terminal, score 2e-166 637910008792 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 637910008793 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 637910008794 glutamine binding [chemical binding]; other site 637910008795 catalytic triad [active] 637910008796 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 637910008797 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 637910008798 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 4e-72 637910008799 PS00442 Glutamine amidotransferases class-I active site. 637910008800 HMMPfam hit to PF02885, Glycosyl transferase, family 3, score 9.1e-25 637910008801 HMMPfam hit to PF00591, Glycosyl transferase, family 3, score 1.9e-153 637910008802 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008803 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 637910008804 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 637910008805 active site 637910008806 ribulose/triose binding site [chemical binding]; other site 637910008807 phosphate binding site [ion binding]; other site 637910008808 substrate (anthranilate) binding pocket [chemical binding]; other site 637910008809 product (indole) binding pocket [chemical binding]; other site 637910008810 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 637910008811 active site 637910008812 HMMPfam hit to PF00218, Indole-3-glycerol phosphate synthase, score 8.9e-155 637910008813 PS00614 Indole-3-glycerol phosphate synthase signature. 637910008814 HMMPfam hit to PF00697, N-(5'phosphoribosyl)anthranilate isomerase (PRAI), score 3.8e-88 637910008815 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 637910008816 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 637910008817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910008818 catalytic residue [active] 637910008819 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 1.1e-120 637910008820 PS00168 Tryptophan synthase subunit beta pyridoxal-phosphate attachment site. 637910008821 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 637910008822 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 637910008823 substrate binding site [chemical binding]; other site 637910008824 active site 637910008825 catalytic residues [active] 637910008826 heterodimer interface [polypeptide binding]; other site 637910008827 HMMPfam hit to PF00290, Tryptophan synthase, subunit alpha, score 8.2e-147 637910008828 PS00167 Tryptophan synthase subunit alpha signature. 637910008829 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 637910008830 dimerization interface [polypeptide binding]; other site 637910008831 metal binding site [ion binding]; metal-binding site 637910008832 HMMPfam hit to PF05974, Protein of unknown function DUF892, score 4.1e-86 637910008833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 637910008834 HMMPfam hit to PF05974, Protein of unknown function DUF892, score 3.5e-69 637910008835 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 637910008836 dimanganese center [ion binding]; other site 637910008837 HMMPfam hit to PF05067, Catalase, manganese, score 9e-134 637910008838 outer membrane protein W; Provisional; Region: PRK10959 637910008839 HMMPfam hit to PF03922, Outer membrane protein, OmpW, score 6.7e-108 637910008840 hypothetical protein; Provisional; Region: PRK02868 637910008841 HMMPfam hit to PF06790, Protein of unknown function UPF0259, score 5e-149 637910008842 6 transmembrane helices predicted for ROD17501 by TMHMM2.0 at aa 20-42, 89-111, 118-140, 144-166, 187-209 and 219-241 637910008843 intracellular septation protein A; Reviewed; Region: PRK00259 637910008844 HMMPfam hit to PF04279, Intracellular septation protein A, score 1.8e-115 637910008845 5 transmembrane helices predicted for ROD17511 by TMHMM2.0 at aa 20-42, 51-68, 78-95, 119-141 and 151-170 637910008846 pseudogene, disrupted by ISCro3 insertion 637910008847 HMMPfam hit to PF07715, TonB-dependent receptor, plug, score 2.8e-32 637910008848 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 3.9e-36 637910008849 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 637910008850 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910008851 HMMPfam hit to PF01609, Transposase, IS4-like, score 3.6e-29 637910008852 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 637910008853 HMMPfam hit to PF03061, Thioesterase superfamily, score 4.8e-20 637910008854 transport protein TonB; Provisional; Region: PRK10819 637910008855 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 637910008856 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 9.6e-19 637910008857 YciI-like protein; Reviewed; Region: PRK11370 637910008858 HMMPfam hit to PF03795, YCII-related, score 1.8e-45 637910008859 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 637910008860 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 637910008861 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 637910008862 putative active site [active] 637910008863 catalytic site [active] 637910008864 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 637910008865 putative active site [active] 637910008866 catalytic site [active] 637910008867 2 transmembrane helices predicted for ROD17591 by TMHMM2.0 at aa 10-29 and 36-58 637910008868 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 8.1e-08 637910008869 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008870 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 6.4e-08 637910008871 dsDNA-mimic protein; Reviewed; Region: PRK05094 637910008872 HMMPfam hit to PF04269, dsDNA mimic, , score 9.3e-37 637910008873 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 637910008874 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637910008875 Walker A/P-loop; other site 637910008876 ATP binding site [chemical binding]; other site 637910008877 Q-loop/lid; other site 637910008878 ABC transporter signature motif; other site 637910008879 Walker B; other site 637910008880 D-loop; other site 637910008881 H-loop/switch region; other site 637910008882 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 637910008883 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter C-terminal, score 5.9e-35 637910008884 HMMPfam hit to PF00005, ABC transporter related, score 3e-64 637910008885 PS00211 ABC transporters family signature. 637910008886 PS00017 ATP/GTP-binding site motif A (P-loop). 637910008887 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 637910008888 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637910008889 Walker A/P-loop; other site 637910008890 ATP binding site [chemical binding]; other site 637910008891 Q-loop/lid; other site 637910008892 ABC transporter signature motif; other site 637910008893 Walker B; other site 637910008894 D-loop; other site 637910008895 H-loop/switch region; other site 637910008896 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 637910008897 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter C-terminal, score 2.8e-30 637910008898 HMMPfam hit to PF00005, ABC transporter related, score 3e-67 637910008899 PS00211 ABC transporters family signature. 637910008900 PS00017 ATP/GTP-binding site motif A (P-loop). 637910008901 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 637910008902 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 637910008903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910008904 dimer interface [polypeptide binding]; other site 637910008905 conserved gate region; other site 637910008906 ABC-ATPase subunit interface; other site 637910008907 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.8e-40 637910008908 6 transmembrane helices predicted for ROD17631 by TMHMM2.0 at aa 40-62, 103-125, 138-160, 164-183, 214-236 and 268-290 637910008909 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910008910 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 637910008911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910008912 dimer interface [polypeptide binding]; other site 637910008913 conserved gate region; other site 637910008914 putative PBP binding loops; other site 637910008915 ABC-ATPase subunit interface; other site 637910008916 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 4.8e-56 637910008917 6 transmembrane helices predicted for ROD17641 by TMHMM2.0 at aa 13-30, 102-121, 134-156, 166-188, 228-250 and 278-300 637910008918 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910008919 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 637910008920 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 637910008921 peptide binding site [polypeptide binding]; other site 637910008922 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 3.3e-86 637910008923 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 637910008924 1 transmembrane helix predicted for ROD17651 by TMHMM2.0 at aa 7-26 637910008925 hypothetical protein; Provisional; Region: PRK11111 637910008926 6 transmembrane helices predicted for ROD17671 by TMHMM2.0 at aa 10-32, 52-74, 78-100, 120-142, 146-168 and 189-211 637910008927 HMMPfam hit to PF01914, Multiple antibiotic resistance (MarC)-related proteins, score 9e-106 637910008928 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 637910008929 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 637910008930 putative catalytic cysteine [active] 637910008931 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 637910008932 putative active site [active] 637910008933 metal binding site [ion binding]; metal-binding site 637910008934 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 7.9e-08 637910008935 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 1.3e-237 637910008936 PS00913 Iron-containing alcohol dehydrogenases signature 1. 637910008937 PS00060 Iron-containing alcohol dehydrogenases signature 2. 637910008938 thymidine kinase; Provisional; Region: PRK04296 637910008939 HMMPfam hit to PF00265, Thymidine kinase, score 7.3e-101 637910008940 PS00603 Thymidine kinase cellular-type signature. 637910008941 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 637910008942 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 637910008943 HMMPfam hit to PF00816, Histone-like nucleoid-structuring protein H-NS, score 1.2e-48 637910008944 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 637910008945 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 637910008946 active site 637910008947 tetramer interface; other site 637910008948 HMMPfam hit to PF00483, Nucleotidyl transferase, score 4.7e-12 637910008949 PS00017 ATP/GTP-binding site motif A (P-loop). 637910008950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910008951 active site 637910008952 response regulator of RpoS; Provisional; Region: PRK10693 637910008953 phosphorylation site [posttranslational modification] 637910008954 intermolecular recognition site; other site 637910008955 dimerization interface [polypeptide binding]; other site 637910008956 HMMPfam hit to PF00072, Response regulator receiver, score 1.7e-42 637910008957 hypothetical protein; Provisional; Region: PRK10279 637910008958 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 637910008959 active site 637910008960 nucleophile elbow; other site 637910008961 HMMPfam hit to PF01734, Patatin, score 2.8e-54 637910008962 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910008963 PS01237 Uncharacterized protein family UPF0028 signature. 637910008964 SEC-C motif; Region: SEC-C; pfam02810 637910008965 hypothetical protein; Provisional; Region: PRK04233 637910008966 HMMPfam hit to PF02810, SEC-C motif, score 6.4e-07 637910008967 HMMPfam hit to PF02810, SEC-C motif, score 1.4e-05 637910008968 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 637910008969 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 637910008970 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 637910008971 putative active site [active] 637910008972 putative substrate binding site [chemical binding]; other site 637910008973 putative cosubstrate binding site; other site 637910008974 catalytic site [active] 637910008975 HMMPfam hit to PF01842, Amino acid-binding ACT, score 2e-06 637910008976 HMMPfam hit to PF00551, Formyl transferase, N-terminal, score 4.8e-79 637910008977 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 637910008978 HMMPfam hit to PF02665, Nitrate reductase, gamma subunit, score 3.7e-117 637910008979 5 transmembrane helices predicted for ROD17791 by TMHMM2.0 at aa 4-26, 55-77, 92-114, 127-149 and 184-206 637910008980 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 637910008981 HMMPfam hit to PF02613, Nitrate reductase, delta subunit, score 4.5e-85 637910008982 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 637910008983 4Fe-4S binding domain; Region: Fer4; cl02805 637910008984 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.011 637910008985 PS00190 Cytochrome c family heme-binding site signature. 637910008986 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 637910008987 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 637910008988 [4Fe-4S] binding site [ion binding]; other site 637910008989 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 637910008990 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 637910008991 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 637910008992 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 637910008993 molybdopterin cofactor binding site; other site 637910008994 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 1.7e-25 637910008995 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 637910008996 PS00037 Myb DNA-binding domain repeat signature 1. 637910008997 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1.9e-178 637910008998 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 637910008999 HMMPfam hit to PF07993, Male sterility C-terminal, score 0.00013 637910009000 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009001 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 0.00041 637910009002 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 637910009003 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 637910009004 12 transmembrane helices predicted for ROD17831 by TMHMM2.0 at aa 38-60, 75-97, 104-123, 133-155, 176-198, 213-235, 256-278, 288-310, 322-344, 348-370, 404-421 and 436-458 637910009005 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 5e-14 637910009006 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 637910009007 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 637910009008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637910009009 dimerization interface [polypeptide binding]; other site 637910009010 Histidine kinase; Region: HisKA_3; pfam07730 637910009011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910009012 ATP binding site [chemical binding]; other site 637910009013 Mg2+ binding site [ion binding]; other site 637910009014 G-X-G motif; other site 637910009015 2 transmembrane helices predicted for ROD17841 by TMHMM2.0 at aa 15-37 and 152-174 637910009016 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 5.3e-12 637910009017 HMMPfam hit to PF07730, Histidine kinase, dimerisation and phosphoacceptor region, score 2.9e-22 637910009018 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 7.4e-23 637910009019 transcriptional regulator NarL; Provisional; Region: PRK10651 637910009020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910009021 active site 637910009022 phosphorylation site [posttranslational modification] 637910009023 intermolecular recognition site; other site 637910009024 dimerization interface [polypeptide binding]; other site 637910009025 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910009026 DNA binding residues [nucleotide binding] 637910009027 dimerization interface [polypeptide binding]; other site 637910009028 HMMPfam hit to PF00072, Response regulator receiver, score 2.9e-42 637910009029 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 7.1e-27 637910009030 PS00622 Bacterial regulatory proteins, luxR family signature. 637910009031 Predicted helix-turn-helix motif with score 1665.000, SD 4.86 at aa 171-192, sequence LPNKMIARRLDITESTVKVHVK 637910009032 putative invasin; Provisional; Region: PRK10177 637910009033 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 637910009034 PS00697 ATP-dependent DNA ligase AMP-binding site. 637910009035 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 637910009036 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 637910009037 [4Fe-4S] binding site [ion binding]; other site 637910009038 molybdopterin cofactor binding site; other site 637910009039 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 637910009040 molybdopterin cofactor binding site; other site 637910009041 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 637910009042 HMMPfam hit to PF04324, BFD-like [2Fe-2S]-binding region, score 2.4e-17 637910009043 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 1.1e-35 637910009044 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 5.2e-126 637910009045 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009046 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 5.6e-22 637910009047 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 637910009048 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 637910009049 nitrite reductase subunit NirD; Provisional; Region: PRK14989 637910009050 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637910009051 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637910009052 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 637910009053 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 637910009054 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 637910009055 PS00017 ATP/GTP-binding site motif A (P-loop). 637910009056 HMMPfam hit to PF01077, Nitrite and sulphite reductase 4Fe-4S region, score 2e-49 637910009057 HMMPfam hit to PF03460, Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like, score 2.3e-22 637910009058 Predicted helix-turn-helix motif with score 982.000, SD 2.53 at aa 875-896, sequence VVKKDICEHFPYSRQEIYHLVR 637910009059 HMMPfam hit to PF04324, BFD-like [2Fe-2S]-binding region, score 7.8e-20 637910009060 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 1.2e-35 637910009061 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 2e-27 637910009062 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 2.3e-42 637910009063 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 7.7e-26 637910009064 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 637910009065 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 637910009066 Walker A/P-loop; other site 637910009067 ATP binding site [chemical binding]; other site 637910009068 Q-loop/lid; other site 637910009069 ABC transporter signature motif; other site 637910009070 Walker B; other site 637910009071 D-loop; other site 637910009072 H-loop/switch region; other site 637910009073 HMMPfam hit to PF00005, ABC transporter related, score 1.3e-68 637910009074 PS00211 ABC transporters family signature. 637910009075 PS00017 ATP/GTP-binding site motif A (P-loop). 637910009076 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 637910009077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910009078 dimer interface [polypeptide binding]; other site 637910009079 conserved gate region; other site 637910009080 putative PBP binding loops; other site 637910009081 ABC-ATPase subunit interface; other site 637910009082 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.3e-18 637910009083 4 transmembrane helices predicted for ROD17901 by TMHMM2.0 at aa 43-62, 101-123, 228-250 and 260-282 637910009084 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 637910009085 NMT1-like family; Region: NMT1_2; pfam13379 637910009086 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009087 Nitrate and nitrite sensing; Region: NIT; pfam08376 637910009088 ANTAR domain; Region: ANTAR; pfam03861 637910009089 HMMPfam hit to PF03861, ANTAR, score 2.5e-21 637910009090 HMMPfam hit to PF08376, Nitrate and nitrite sensing, score 4.3e-70 637910009091 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 637910009092 HMMPfam hit to PF02635, DsrE-like protein, score 1.6e-37 637910009093 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 637910009094 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 637910009095 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 637910009096 putative active site pocket [active] 637910009097 dimerization interface [polypeptide binding]; other site 637910009098 putative catalytic residue [active] 637910009099 HMMPfam hit to PF04752, ChaC-like protein, score 1.2e-89 637910009100 cation transport regulator; Reviewed; Region: chaB; PRK09582 637910009101 HMMPfam hit to PF06150, ChaB, score 7.3e-11 637910009102 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 637910009103 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 637910009104 11 transmembrane helices predicted for ROD17971 by TMHMM2.0 at aa 13-32, 36-58, 71-93, 108-127, 139-161, 166-188, 220-237, 247-269, 290-312, 317-339 and 346-365 637910009105 HMMPfam hit to PF01699, Sodium/calcium exchanger membrane region, score 2.2e-12 637910009106 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 637910009107 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 637910009108 HMMPfam hit to PF00793, DAHP synthetase I/KDSA, score 6.3e-116 637910009109 hypothetical protein; Provisional; Region: PRK10941 637910009110 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 637910009111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 637910009112 TPR motif; other site 637910009113 binding surface 637910009114 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 637910009115 hypothetical protein; Provisional; Region: PRK10278 637910009116 HMMPfam hit to PF04247, Invasion gene expression up-regulator, SirB, score 4.1e-57 637910009117 4 transmembrane helices predicted for ROD18001 by TMHMM2.0 at aa 4-26, 39-61, 71-93 and 105-124 637910009118 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 637910009119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910009120 PS00092 N-6 Adenine-specific DNA methylases signature. 637910009121 HMMPfam hit to PF08241, Methyltransferase type 11, score 8.7e-08 637910009122 peptide chain release factor 1; Validated; Region: prfA; PRK00591 637910009123 This domain is found in peptide chain release factors; Region: PCRF; smart00937 637910009124 RF-1 domain; Region: RF-1; pfam00472 637910009125 HMMPfam hit to PF00472, Class I peptide chain release factor, score 1.6e-75 637910009126 PS00745 Prokaryotic-type class I peptide chain release factors signature. 637910009127 HMMPfam hit to PF03462, PCRF, score 5.5e-74 637910009128 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 637910009129 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 637910009130 tRNA; other site 637910009131 putative tRNA binding site [nucleotide binding]; other site 637910009132 putative NADP binding site [chemical binding]; other site 637910009133 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 637910009134 HMMPfam hit to PF00745, Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, C-terminal, score 4.3e-37 637910009135 HMMPfam hit to PF01488, Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase, score 3.2e-66 637910009136 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009137 HMMPfam hit to PF05201, Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, N-terminal, score 1.7e-85 637910009138 PS00747 Glutamyl-tRNA reductase signature. 637910009139 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 637910009140 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 637910009141 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009142 PS00017 ATP/GTP-binding site motif A (P-loop). 637910009143 HMMPfam hit to PF03550, Outer membrane lipoprotein LolB, score 9.6e-82 637910009144 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 637910009145 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 637910009146 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 637910009147 HMMPfam hit to PF00288, GHMP kinase, score 2e-20 637910009148 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 3.3e-09 637910009149 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 637910009150 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 637910009151 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637910009152 active site 637910009153 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910009154 PS00114 Phosphoribosyl pyrophosphate synthetase signature. 637910009155 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 2.1e-37 637910009156 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 637910009157 putative transporter; Provisional; Region: PRK11660 637910009158 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 637910009159 Sulfate transporter family; Region: Sulfate_transp; pfam00916 637910009160 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 637910009161 10 transmembrane helices predicted for ROD18071 by TMHMM2.0 at aa 33-55, 100-122, 127-149, 177-199, 212-234, 277-299, 319-341, 346-368, 370-388 and 408-439 637910009162 PS01130 Sulfate transporters signature. 637910009163 HMMPfam hit to PF00916, Sulphate transporter score 2.4e-104 637910009164 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009165 HMMPfam hit to PF01740, Sulphate transporter/antisigma-factor antagonist STAS, score 1.5e-23 637910009166 hypothetical protein; Provisional; Region: PRK10692 637910009167 2 transmembrane helices predicted for ROD18081 by TMHMM2.0 at aa 7-29 and 39-61 637910009168 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 637910009169 putative active site [active] 637910009170 catalytic residue [active] 637910009171 HMMPfam hit to PF01195, Peptidyl-tRNA hydrolase, score 9e-112 637910009172 PS01196 Peptidyl-tRNA hydrolase signature 2. 637910009173 PS00217 Sugar transport proteins signature 2. 637910009174 GTP-binding protein YchF; Reviewed; Region: PRK09601 637910009175 YchF GTPase; Region: YchF; cd01900 637910009176 G1 box; other site 637910009177 GTP/Mg2+ binding site [chemical binding]; other site 637910009178 Switch I region; other site 637910009179 G2 box; other site 637910009180 Switch II region; other site 637910009181 G3 box; other site 637910009182 G4 box; other site 637910009183 G5 box; other site 637910009184 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 637910009185 PS00443 Glutamine amidotransferases class-II active site. 637910009186 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 1.5e-31 637910009187 PS00017 ATP/GTP-binding site motif A (P-loop). 637910009188 HMMPfam hit to PF06071, Protein of unknown function DUF933, score 3.5e-60 637910009189 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 637910009190 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 637910009191 PS00017 ATP/GTP-binding site motif A (P-loop). 637910009192 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637910009193 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 637910009194 DNA binding residues [nucleotide binding] 637910009195 dimerization interface [polypeptide binding]; other site 637910009196 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 2e-09 637910009197 PS00622 Bacterial regulatory proteins, luxR family signature. 637910009198 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637910009199 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 6.4e-12 637910009200 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637910009201 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 4.8e-05 637910009202 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009203 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 637910009204 PapC N-terminal domain; Region: PapC_N; pfam13954 637910009205 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637910009206 PapC C-terminal domain; Region: PapC_C; pfam13953 637910009207 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 0 637910009208 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 637910009209 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 637910009210 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 637910009211 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 637910009212 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637910009213 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637910009214 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 1e-18 637910009215 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 6.1e-50 637910009216 PS00635 Gram-negative pili assembly chaperone signature. 637910009217 1 transmembrane helix predicted for ROD18171 by TMHMM2.0 at aa 3-25 637910009218 Fimbrial protein; Region: Fimbrial; cl01416 637910009219 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 1.9e-28 637910009220 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 637910009221 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 637910009222 trehalase; Provisional; Region: treA; PRK13271 637910009223 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 637910009224 HMMPfam hit to PF01204, Glycoside hydrolase, family 37, score 3.7e-267 637910009225 PS00927 Trehalase signature 1. 637910009226 PS00928 Trehalase signature 2. 637910009227 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 637910009228 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637910009229 N-terminal plug; other site 637910009230 ligand-binding site [chemical binding]; other site 637910009231 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 5.3e-18 637910009232 HMMPfam hit to PF07715, TonB-dependent receptor, plug, score 1.4e-16 637910009233 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 637910009234 HMMPfam hit to PF04226, Transglycosylase-associated protein, score 2.3e-20 637910009235 3 transmembrane helices predicted for ROD18231 by TMHMM2.0 at aa 4-22, 27-49 and 59-81 637910009236 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 637910009237 Flagellar regulator YcgR; Region: YcgR; pfam07317 637910009238 PilZ domain; Region: PilZ; pfam07238 637910009239 HMMPfam hit to PF07317, YcgR, score 1.7e-47 637910009240 HMMPfam hit to PF07238, type IV pilus assembly PilZ, score 2e-13 637910009241 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 637910009242 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637910009243 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637910009244 catalytic residue [active] 637910009245 HMMPfam hit to PF01464, Lytic transglycosylase-like, catalytic, score 1.3e-37 637910009246 PS00922 Prokaryotic transglycosylases signature. 637910009247 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009248 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 637910009249 dimer interface [polypeptide binding]; other site 637910009250 catalytic triad [active] 637910009251 HMMPfam hit to PF02016, Peptidase S66, LD-carboxypeptidase A, score 3.3e-44 637910009252 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 637910009253 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 637910009254 TrkA-C domain; Region: TrkA_C; pfam02080 637910009255 Transporter associated domain; Region: CorC_HlyC; smart01091 637910009256 12 transmembrane helices predicted for ROD18271 by TMHMM2.0 at aa 5-27, 31-53, 60-78, 93-115, 122-141, 187-209, 216-238, 243-261, 273-290, 300-322, 334-356 and 361-383 637910009257 HMMPfam hit to PF00999, Sodium/hydrogen exchanger, score 1.4e-72 637910009258 HMMPfam hit to PF02080, TrkA-C, score 1.2e-09 637910009259 HMMPfam hit to PF03471, Transporter-associated region, score 2.2e-23 637910009260 alanine racemase; Reviewed; Region: dadX; PRK03646 637910009261 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 637910009262 active site 637910009263 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637910009264 substrate binding site [chemical binding]; other site 637910009265 catalytic residues [active] 637910009266 dimer interface [polypeptide binding]; other site 637910009267 HMMPfam hit to PF00842, Alanine racemase, C-terminal, score 1.6e-65 637910009268 HMMPfam hit to PF01168, Alanine racemase, N-terminal, score 7.1e-86 637910009269 PS00395 Alanine racemase pyridoxal-phosphate attachment site. 637910009270 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 637910009271 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637910009272 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 4e-106 637910009273 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009274 SpoVR family protein; Provisional; Region: PRK11767 637910009275 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 637910009276 HMMPfam hit to PF04293, Sporulation stage V, protein R, score 0 637910009277 fatty acid metabolism regulator; Provisional; Region: PRK04984 637910009278 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910009279 DNA-binding site [nucleotide binding]; DNA binding site 637910009280 FadR C-terminal domain; Region: FadR_C; pfam07840 637910009281 HMMPfam hit to PF07840, Fatty acid responsive transcription factor FadR, C-terminal, score 5.1e-120 637910009282 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 7.4e-26 637910009283 PS00043 Bacterial regulatory proteins, gntR family signature. 637910009284 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 637910009285 transmembrane helices; other site 637910009286 HMMPfam hit to PF06450, Na+/H+ antiporter NhaB, score 0 637910009287 12 transmembrane helices predicted for ROD18321 by TMHMM2.0 at aa 26-48, 61-80, 95-117, 122-144, 148-165, 197-219, 239-261, 299-331, 346-368, 389-411, 453-472 and 479-501 637910009288 disulfide bond formation protein B; Provisional; Region: PRK01749 637910009289 HMMPfam hit to PF02600, Disulphide bond formation protein DsbB, score 5.3e-73 637910009290 4 transmembrane helices predicted for ROD18331 by TMHMM2.0 at aa 13-32, 42-64, 71-89 and 144-166 637910009291 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 637910009292 HMMPfam hit to PF09313, Protein of unknown function DUF1971, score 5.7e-45 637910009293 hypothetical protein; Provisional; Region: PRK05170 637910009294 HMMPfam hit to PF03692, Protein of unknown function UPF0153, score 4.8e-24 637910009295 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 637910009296 hypothetical protein; Provisional; Region: PRK10691 637910009297 HMMPfam hit to PF01557, Fumarylacetoacetase, C-terminal-like, score 5.3e-89 637910009298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 637910009299 HMMPfam hit to PF05166, Protein of unknown function DUF709, score 2.2e-58 637910009300 septum formation inhibitor; Reviewed; Region: minC; PRK03511 637910009301 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 637910009302 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 637910009303 HMMPfam hit to PF05209, Septum formation inhibitor MinC, N-terminal, score 4.7e-49 637910009304 HMMPfam hit to PF03775, Septum formation inhibitor MinC, C-terminal, score 4.7e-63 637910009305 cell division inhibitor MinD; Provisional; Region: PRK10818 637910009306 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 637910009307 Switch I; other site 637910009308 Switch II; other site 637910009309 HMMPfam hit to PF01656, Cobyrinic acid a,c-diamide synthase, score 2.8e-26 637910009310 PS00017 ATP/GTP-binding site motif A (P-loop). 637910009311 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 637910009312 HMMPfam hit to PF03776, Septum formation topological specificity factor MinE, score 2.5e-54 637910009313 transcriptional activator TtdR; Provisional; Region: PRK09801 637910009314 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910009315 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 637910009316 putative effector binding pocket; other site 637910009317 putative dimerization interface [polypeptide binding]; other site 637910009318 HMMPfam hit to PF03466, LysR, substrate-binding, score 3.4e-40 637910009319 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2.3e-15 637910009320 PS00044 Bacterial regulatory proteins, lysR family signature. 637910009321 Predicted helix-turn-helix motif with score 1426.000, SD 4.04 at aa 20-41, sequence AGFAAVAQEMGVSPAFVSKRIA 637910009322 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 637910009323 tartrate dehydrogenase; Region: TTC; TIGR02089 637910009324 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 5.2e-98 637910009325 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 637910009326 ribonuclease D; Provisional; Region: PRK10829 637910009327 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 637910009328 catalytic site [active] 637910009329 putative active site [active] 637910009330 putative substrate binding site [chemical binding]; other site 637910009331 Helicase and RNase D C-terminal; Region: HRDC; smart00341 637910009332 HMMPfam hit to PF00570, Helicase and RNase D C-terminal, HRDC, score 2.3e-27 637910009333 HMMPfam hit to PF01612, 3'-5' exonuclease, score 1.7e-68 637910009334 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 637910009335 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 637910009336 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 637910009337 acyl-activating enzyme (AAE) consensus motif; other site 637910009338 putative AMP binding site [chemical binding]; other site 637910009339 putative active site [active] 637910009340 putative CoA binding site [chemical binding]; other site 637910009341 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 2.2e-136 637910009342 PS00455 AMP-binding domain signature. 637910009343 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 637910009344 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 637910009345 HMMPfam hit to PF03843, Outer membrane lipoprotein Slp, score 3.2e-92 637910009346 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009347 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 637910009348 Glycoprotease family; Region: Peptidase_M22; pfam00814 637910009349 HMMPfam hit to PF00814, Peptidase M22, glycoprotease, score 2.8e-50 637910009350 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 637910009351 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 637910009352 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 637910009353 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/type III, Res subunit, score 2e-05 637910009354 PS00017 ATP/GTP-binding site motif A (P-loop). 637910009355 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 637910009356 homotrimer interaction site [polypeptide binding]; other site 637910009357 putative active site [active] 637910009358 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 7.5e-36 637910009359 PS01094 Uncharacterized protein family UPF0076 signature. 637910009360 hypothetical protein; Provisional; Region: PRK05114 637910009361 HMMPfam hit to PF03701, Protein of unknown function UPF0181, score 9.1e-32 637910009362 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 637910009363 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 637910009364 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 637910009365 HMMPfam hit to PF04715, Anthranilate synthase component I, N-terminal, score 1.2e-32 637910009366 HMMPfam hit to PF00425, Chorismate binding, C-terminal, score 3.2e-147 637910009367 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 637910009368 putative active site [active] 637910009369 putative CoA binding site [chemical binding]; other site 637910009370 nudix motif; other site 637910009371 metal binding site [ion binding]; metal-binding site 637910009372 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 5.4e-19 637910009373 PS01293 Uncharacterized protein family UPF0035 signature. 637910009374 L-serine deaminase; Provisional; Region: PRK15023 637910009375 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 637910009376 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 637910009377 HMMPfam hit to PF03315, Serine dehydratase subunit beta, score 2.4e-105 637910009378 HMMPfam hit to PF03313, Serine dehydratase subunit alpha, score 2e-203 637910009379 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009380 phage resistance protein; Provisional; Region: PRK10551 637910009381 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 637910009382 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637910009383 1 transmembrane helix predicted for ROD18531 by TMHMM2.0 at aa 17-36 637910009384 PS00678 Trp-Asp (WD) repeats signature. 637910009385 HMMPfam hit to PF00563, EAL, score 1.7e-109 637910009386 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 637910009387 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 637910009388 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637910009389 Transporter associated domain; Region: CorC_HlyC; smart01091 637910009390 HMMPfam hit to PF03471, Transporter-associated region, score 2.1e-18 637910009391 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 3.6e-22 637910009392 7 transmembrane helices predicted for ROD18541 by TMHMM2.0 at aa 13-35, 48-70, 85-102, 123-145, 155-172, 185-207 and 212-231 637910009393 HMMPfam hit to PF03741, Integral membrane protein TerC, score 1.5e-35 637910009394 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 637910009395 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 637910009396 active pocket/dimerization site; other site 637910009397 active site 637910009398 phosphorylation site [posttranslational modification] 637910009399 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 637910009400 active site 637910009401 phosphorylation site [posttranslational modification] 637910009402 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 2e-51 637910009403 HMMPfam hit to PF03830, Phosphotransferase system, sorbose subfamily IIB component, score 2.7e-96 637910009404 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 637910009405 HMMPfam hit to PF03609, Phosphotransferase system, sorbose-specific IIC subunit, score 2e-150 637910009406 7 transmembrane helices predicted for ROD18561 by TMHMM2.0 at aa 5-27, 34-56, 66-88, 95-117, 143-165, 178-200 and 215-237 637910009407 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009408 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 637910009409 HMMPfam hit to PF03613, Phosphotransferase system, mannose/fructose/sorbose family IID component, score 1.6e-188 637910009410 2 transmembrane helices predicted for ROD18571 by TMHMM2.0 at aa 135-157 and 262-284 637910009411 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009412 hypothetical protein; Provisional; Region: PRK02913 637910009413 HMMPfam hit to PF06173, Protein of unknown function DUF986, score 6.5e-102 637910009414 2 transmembrane helices predicted for ROD18581 by TMHMM2.0 at aa 7-26 and 68-87 637910009415 hypothetical protein; Provisional; Region: PRK11469 637910009416 Domain of unknown function DUF; Region: DUF204; pfam02659 637910009417 Domain of unknown function DUF; Region: DUF204; pfam02659 637910009418 HMMPfam hit to PF02659, Protein of unknown function DUF204, score 7.9e-36 637910009419 6 transmembrane helices predicted for ROD18591 by TMHMM2.0 at aa 7-29, 39-61, 68-86, 106-128, 133-155 and 165-187 637910009420 HMMPfam hit to PF02659, Protein of unknown function DUF204, score 1.4e-31 637910009421 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009422 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 637910009423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910009424 S-adenosylmethionine binding site [chemical binding]; other site 637910009425 HMMPfam hit to PF08241, Methyltransferase type 11, score 5.1e-16 637910009426 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 637910009427 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 637910009428 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 637910009429 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 1.9e-104 637910009430 HMMPfam hit to PF03717, Penicillin-binding protein, dimerisation domain, score 1.2e-49 637910009431 Predicted helix-turn-helix motif with score 987.000, SD 2.55 at aa 101-122, sequence ARWQALADTLHLSLSTLAERVN 637910009432 1 transmembrane helix predicted for ROD18611 by TMHMM2.0 at aa 16-38 637910009433 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 637910009434 DNA-binding site [nucleotide binding]; DNA binding site 637910009435 RNA-binding motif; other site 637910009436 HMMPfam hit to PF00313, Cold-shock protein, DNA-binding, score 3.2e-43 637910009437 PS00352 'Cold-shock' DNA-binding domain signature. 637910009438 YebO-like protein; Region: YebO; pfam13974 637910009439 PS00017 ATP/GTP-binding site motif A (P-loop). 637910009440 1 transmembrane helix predicted for ROD18641 by TMHMM2.0 at aa 10-32 637910009441 PhoPQ regulatory protein; Provisional; Region: PRK10299 637910009442 1 transmembrane helix predicted for ROD18651 by TMHMM2.0 at aa 7-25 637910009443 YobH-like protein; Region: YobH; pfam13996 637910009444 1 transmembrane helix predicted for ROD18661 by TMHMM2.0 at aa 7-29 637910009445 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 637910009446 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637910009447 dimerization interface [polypeptide binding]; other site 637910009448 putative Zn2+ binding site [ion binding]; other site 637910009449 putative DNA binding site [nucleotide binding]; other site 637910009450 Bacterial transcriptional regulator; Region: IclR; pfam01614 637910009451 HMMPfam hit to PF01614, Transcriptional regulator IclR, C-terminal, score 7e-65 637910009452 PS01051 Bacterial regulatory proteins, iclR family signature. 637910009453 HMMPfam hit to PF09339, Transcriptional regulator IclR, N-terminal, score 3e-29 637910009454 Predicted helix-turn-helix motif with score 1951.000, SD 5.83 at aa 32-53, sequence IGITELSQRVMMSKSTVYRFLQ 637910009455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910009456 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637910009457 putative substrate translocation pore; other site 637910009458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910009459 12 transmembrane helices predicted for ROD18681 by TMHMM2.0 at aa 21-43, 53-75, 87-109, 113-132, 144-166, 171-193, 205-227, 231-249, 269-291, 306-328, 335-357 and 426-448 637910009460 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.8e-55 637910009461 heat shock protein HtpX; Provisional; Region: PRK05457 637910009462 HMMPfam hit to PF01435, Peptidase M48, Ste24p, score 1.5e-46 637910009463 4 transmembrane helices predicted for ROD18691 by TMHMM2.0 at aa 5-27, 32-54, 158-180 and 195-217 637910009464 HMMPfam hit to PF06509, Peptidase M48B, HtpX peptidase N-terminal, score 7e-55 637910009465 carboxy-terminal protease; Provisional; Region: PRK11186 637910009466 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 637910009467 protein binding site [polypeptide binding]; other site 637910009468 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 637910009469 Catalytic dyad [active] 637910009470 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 637910009471 HMMPfam hit to PF03572, Peptidase S41, score 5.7e-65 637910009472 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 3.3e-17 637910009473 ProP expression regulator; Provisional; Region: PRK04950 637910009474 ProQ/FINO family; Region: ProQ; pfam04352 637910009475 HMMPfam hit to PF04352, ProQ activator of osmoprotectant transporter ProP, score 6.5e-97 637910009476 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 637910009477 GAF domain; Region: GAF_2; pfam13185 637910009478 HMMPfam hit to PF01590, GAF, score 1.7e-07 637910009479 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 637910009480 Paraquat-inducible protein A; Region: PqiA; pfam04403 637910009481 Paraquat-inducible protein A; Region: PqiA; pfam04403 637910009482 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 3.1e-96 637910009483 8 transmembrane helices predicted for ROD18731 by TMHMM2.0 at aa 65-84, 119-141, 162-184, 188-210, 268-290, 314-336, 356-378 and 383-405 637910009484 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 1.2e-97 637910009485 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 637910009486 mce related protein; Region: MCE; pfam02470 637910009487 mce related protein; Region: MCE; pfam02470 637910009488 mce related protein; Region: MCE; pfam02470 637910009489 mce related protein; Region: MCE; pfam02470 637910009490 mce related protein; Region: MCE; pfam02470 637910009491 mce related protein; Region: MCE; pfam02470 637910009492 1 transmembrane helix predicted for ROD18741 by TMHMM2.0 at aa 20-39 637910009493 HMMPfam hit to PF02470, Mammalian cell entry related, score 3.9e-31 637910009494 HMMPfam hit to PF02470, Mammalian cell entry related, score 8.7e-05 637910009495 HMMPfam hit to PF02470, Mammalian cell entry related, score 5.3e-15 637910009496 HMMPfam hit to PF02470, Mammalian cell entry related, score 5.5e-06 637910009497 HMMPfam hit to PF02470, Mammalian cell entry related, score 0.00091 637910009498 HMMPfam hit to PF02470, Mammalian cell entry related, score 1.5e-20 637910009499 HMMPfam hit to PF02470, Mammalian cell entry related, score 3.8e-17 637910009500 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 637910009501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910009502 S-adenosylmethionine binding site [chemical binding]; other site 637910009503 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 637910009504 PS01153 NOL1/NOP2/sun family signature. 637910009505 HMMPfam hit to PF01189, Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, score 5.5e-73 637910009506 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 637910009507 HMMPfam hit to PF07351, Protein of unknown function DUF1480, score 3.8e-67 637910009508 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 637910009509 HMMPfam hit to PF07358, Protein of unknown function DUF1482, score 1.1e-39 637910009510 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 637910009511 1 transmembrane helix predicted for ROD18781 by TMHMM2.0 at aa 4-26 637910009512 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 637910009513 HMMPfam hit to PF05425, Copper resistance D, score 2.5e-97 637910009514 8 transmembrane helices predicted for ROD18791 by TMHMM2.0 at aa 11-30, 51-73, 93-111, 118-137, 152-174, 195-217, 227-249 and 262-284 637910009515 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009516 hypothetical protein; Provisional; Region: PRK10301 637910009517 HMMPfam hit to PF04234, Copper resistance protein CopC, core, score 1e-54 637910009518 1 transmembrane helix predicted for ROD18801 by TMHMM2.0 at aa 12-29 637910009519 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 637910009520 HMMPfam hit to PF06440, DNA polymerase III-theta, bacterial, score 5.6e-53 637910009521 Predicted amidohydrolase [General function prediction only]; Region: COG0388 637910009522 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 637910009523 HMMPfam hit to PF00795, Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase, score 9.3e-07 637910009524 exodeoxyribonuclease X; Provisional; Region: PRK07983 637910009525 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 637910009526 active site 637910009527 catalytic site [active] 637910009528 substrate binding site [chemical binding]; other site 637910009529 HMMPfam hit to PF00929, Exonuclease, RNase T and DNA polymerase III, score 1.7e-21 637910009530 protease 2; Provisional; Region: PRK10115 637910009531 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 637910009532 HMMPfam hit to PF00326, Peptidase S9, prolyl oligopeptidase active site region, score 1.9e-105 637910009533 PS00708 Prolyl endopeptidase family serine active site. 637910009534 HMMPfam hit to PF02897, Peptidase S9A, oligopeptidase, N-terminal beta-propeller, score 1.5e-149 637910009535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 637910009536 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 637910009537 putative metal binding site [ion binding]; other site 637910009538 HMMPfam hit to PF04391, Protein of unknown function DUF533, score 7.8e-100 637910009539 hypothetical protein; Provisional; Region: PRK13680 637910009540 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 637910009541 HMMPfam hit to PF07130, YebG, score 6.8e-51 637910009542 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 637910009543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637910009544 ATP-grasp domain; Region: ATP-grasp; pfam02222 637910009545 HMMPfam hit to PF02222, ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type, score 8.6e-104 637910009546 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 637910009547 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 637910009548 active site 637910009549 intersubunit interface [polypeptide binding]; other site 637910009550 catalytic residue [active] 637910009551 HMMPfam hit to PF01081, KDPG and KHG aldolase, score 3e-137 637910009552 PS00160 KDPG and KHG aldolases Schiff-base forming residue. 637910009553 PS00159 KDPG and KHG aldolases active site. 637910009554 phosphogluconate dehydratase; Validated; Region: PRK09054 637910009555 6-phosphogluconate dehydratase; Region: edd; TIGR01196 637910009556 HMMPfam hit to PF00920, Dihydroxy-acid and 6-phosphogluconate dehydratase, score 3.4e-281 637910009557 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 637910009558 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 637910009559 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009560 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 637910009561 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 637910009562 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 637910009563 HMMPfam hit to PF02781, Glucose-6-phosphate dehydrogenase, score 2.9e-205 637910009564 HMMPfam hit to PF00479, Glucose-6-phosphate dehydrogenase, score 9.9e-106 637910009565 PS00069 Glucose-6-phosphate dehydrogenase active site. 637910009566 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 637910009567 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637910009568 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 637910009569 putative active site [active] 637910009570 HMMPfam hit to PF01418, Helix-turn-helix protein RpiR, score 5.1e-58 637910009571 Predicted helix-turn-helix motif with score 1719.000, SD 5.04 at aa 35-56, sequence CSIATLAQEANVSEPTVNRFCR 637910009572 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 1.4e-38 637910009573 pyruvate kinase; Provisional; Region: PRK05826 637910009574 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 637910009575 domain interfaces; other site 637910009576 active site 637910009577 HMMPfam hit to PF00224, Pyruvate kinase, barrel, score 1.3e-222 637910009578 PS00110 Pyruvate kinase active site signature. 637910009579 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta, score 2.5e-59 637910009580 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 637910009581 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910009582 HMMPfam hit to PF01609, Transposase, IS4-like, score 3.6e-29 637910009583 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 637910009584 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 637910009585 putative acyl-acceptor binding pocket; other site 637910009586 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltransferase, score 2.5e-156 637910009587 1 transmembrane helix predicted for ROD18961 by TMHMM2.0 at aa 24-43 637910009588 putative peptidase; Provisional; Region: PRK11649 637910009589 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 637910009590 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637910009591 Peptidase family M23; Region: Peptidase_M23; pfam01551 637910009592 HMMPfam hit to PF01551, Peptidase M23B, score 1.7e-58 637910009593 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 2.4e-07 637910009594 HMMPfam hit to PF08525, Opacity-associated protein A, N-terminal, score 3.6e-07 637910009595 1 transmembrane helix predicted for ROD18971 by TMHMM2.0 at aa 21-40 637910009596 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 637910009597 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 637910009598 metal binding site [ion binding]; metal-binding site 637910009599 HMMPfam hit to PF01297, Periplasmic solute binding protein, score 9.4e-31 637910009600 1 transmembrane helix predicted for ROD18981 by TMHMM2.0 at aa 7-29 637910009601 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 637910009602 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 637910009603 HMMPfam hit to PF00005, ABC transporter related, score 1e-47 637910009604 PS00017 ATP/GTP-binding site motif A (P-loop). 637910009605 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 637910009606 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637910009607 ABC-ATPase subunit interface; other site 637910009608 dimer interface [polypeptide binding]; other site 637910009609 putative PBP binding regions; other site 637910009610 HMMPfam hit to PF00950, ABC-3, score 4.7e-122 637910009611 7 transmembrane helices predicted for ROD19001 by TMHMM2.0 at aa 5-27, 48-70, 85-107, 127-145, 170-192, 213-235 and 239-256 637910009612 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009613 1 transmembrane helix predicted for ROD19011 by TMHMM2.0 at aa 4-26 637910009614 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 637910009615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910009616 Walker A motif; other site 637910009617 ATP binding site [chemical binding]; other site 637910009618 Walker B motif; other site 637910009619 arginine finger; other site 637910009620 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 637910009621 HMMPfam hit to PF05491, DNA helicase, Holliday junction RuvB type, C-terminal, score 3.9e-55 637910009622 HMMPfam hit to PF00004, AAA ATPase, core, score 1.3e-34 637910009623 PS00017 ATP/GTP-binding site motif A (P-loop). 637910009624 HMMPfam hit to PF05496, DNA helicase, Holliday junction RuvB type, N-terminal, score 1.1e-28 637910009625 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 637910009626 RuvA N terminal domain; Region: RuvA_N; pfam01330 637910009627 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 637910009628 HMMPfam hit to PF07499, DNA helicase, Holliday junction RuvA type, C-terminal domain III, score 1.7e-16 637910009629 HMMPfam hit to PF01330, DNA helicase, Holliday junction RuvA type, domain I, bacterial, score 2.3e-28 637910009630 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 637910009631 active site 637910009632 putative DNA-binding cleft [nucleotide binding]; other site 637910009633 dimer interface [polypeptide binding]; other site 637910009634 HMMPfam hit to PF02075, Crossover junction endodeoxyribonuclease RuvC, score 1.2e-103 637910009635 PS01321 Crossover junction endodeoxyribonuclease ruvC signature. 637910009636 hypothetical protein; Validated; Region: PRK00110 637910009637 HMMPfam hit to PF01709, Protein of unknown function DUF28, score 1.6e-151 637910009638 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 637910009639 nudix motif; other site 637910009640 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 1.1e-28 637910009641 PS00893 mutT domain signature. 637910009642 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 637910009643 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 637910009644 dimer interface [polypeptide binding]; other site 637910009645 anticodon binding site; other site 637910009646 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 637910009647 homodimer interface [polypeptide binding]; other site 637910009648 motif 1; other site 637910009649 active site 637910009650 motif 2; other site 637910009651 GAD domain; Region: GAD; pfam02938 637910009652 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 637910009653 active site 637910009654 motif 3; other site 637910009655 HMMPfam hit to PF00152, Aminoacyl-tRNA synthetase, class II (D, K and N), score 1.3e-215 637910009656 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910009657 HMMPfam hit to PF02938, GAD, score 5.6e-52 637910009658 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 637910009659 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 3.2e-28 637910009660 Isochorismatase family; Region: Isochorismatase; pfam00857 637910009661 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 637910009662 catalytic triad [active] 637910009663 conserved cis-peptide bond; other site 637910009664 HMMPfam hit to PF00857, Isochorismatase hydrolase, score 2.1e-71 637910009665 pseudogene, N-terminus missing, C-terminal part fragmented by two frameshift mutations 637910009666 HMMPfam hit to PF00078, RNA-directed DNA polymerase (reverse transcriptase), score 1.6e-20 637910009667 HMMPfam hit to PF00078, RNA-directed DNA polymerase (reverse transcriptase), score 1e-14 637910009668 PS00017 ATP/GTP-binding site motif A (P-loop). 637910009669 pseudogene, N- and C-termini missing, fragmented by two frameshift mutations 637910009670 HMMPfam hit to PF00290, Tryptophan synthase, subunit alpha, score 2.2e-09 637910009671 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 637910009672 3 transmembrane helices predicted for ROD19151 by TMHMM2.0 at aa 5-27, 71-93 and 106-128 637910009673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910009674 S-adenosylmethionine binding site [chemical binding]; other site 637910009675 HMMPfam hit to PF08241, Methyltransferase type 11, score 4.4e-12 637910009676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910009677 S-adenosylmethionine binding site [chemical binding]; other site 637910009678 HMMPfam hit to PF08003, Methyltransferase, , score 4.8e-252 637910009679 copper homeostasis protein CutC; Provisional; Region: PRK11572 637910009680 HMMPfam hit to PF03932, CutC, score 4.4e-125 637910009681 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 637910009682 putative metal binding site [ion binding]; other site 637910009683 HMMPfam hit to PF06185, Protein of unknown function DUF991, score 4.9e-114 637910009684 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 637910009685 arginyl-tRNA synthetase; Region: argS; TIGR00456 637910009686 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 637910009687 active site 637910009688 HIGH motif; other site 637910009689 KMSK motif region; other site 637910009690 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 637910009691 tRNA binding surface [nucleotide binding]; other site 637910009692 anticodon binding site; other site 637910009693 HMMPfam hit to PF03485, Arginyl tRNA synthetase, class Ic, N-terminal, score 2.2e-31 637910009694 HMMPfam hit to PF00750, Arginyl-tRNA synthetase, class Ic, core, score 8e-212 637910009695 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 637910009696 HMMPfam hit to PF05746, DALR anticodon binding, score 3.3e-51 637910009697 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 637910009698 HMMPfam hit to PF07470, Glycosyl hydrolase, family 88, score 2.1e-158 637910009699 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 637910009700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910009701 12 transmembrane helices predicted for ROD19221 by TMHMM2.0 at aa 13-35, 45-67, 86-103, 108-130, 151-173, 178-200, 250-272, 287-309, 316-335, 339-361, 397-414 and 424-446 637910009702 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009703 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.1e-10 637910009704 Flagellar protein FlhE; Region: FlhE; pfam06366 637910009705 HMMPfam hit to PF06366, Flagellar FlhE, score 1.6e-82 637910009706 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 637910009707 FHIPEP family; Region: FHIPEP; pfam00771 637910009708 HMMPfam hit to PF00771, Bacterial type III secretion FHIPEP, score 0 637910009709 7 transmembrane helices predicted for ROD19241 by TMHMM2.0 at aa 21-43, 47-64, 76-98, 118-140, 209-231, 251-273 and 293-327 637910009710 PS00994 Bacterial export FHIPEP family signature. 637910009711 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 637910009712 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 637910009713 HMMPfam hit to PF01312, type III secretion exporter, score 2.9e-178 637910009714 4 transmembrane helices predicted for ROD19251 by TMHMM2.0 at aa 32-49, 92-114, 142-164 and 188-210 637910009715 PS00017 ATP/GTP-binding site motif A (P-loop). 637910009716 pseudogene, C-terminus missing, N-terminal part truncated by frameshift mutation 637910009717 HMMPfam hit to PF05593, YD repeat, score 3.6 637910009718 HMMPfam hit to PF05593, YD repeat, score 0.027 637910009719 HMMPfam hit to PF05593, YD repeat, score 0.0037 637910009720 HMMPfam hit to PF05593, YD repeat, score 0.00044 637910009721 HMMPfam hit to PF05593, YD repeat, score 0.0029 637910009722 HMMPfam hit to PF05593, YD repeat, score 0.00021 637910009723 HMMPfam hit to PF05593, YD repeat, score 9.3e-07 637910009724 HMMPfam hit to PF05593, YD repeat, score 0.19 637910009725 HMMPfam hit to PF05593, YD repeat, score 0.00032 637910009726 HMMPfam hit to PF05593, YD repeat, score 0.0065 637910009727 HMMPfam hit to PF05593, YD repeat, score 0.047 637910009728 HMMPfam hit to PF03527, RHS protein, score 7.8e-23 637910009729 HMMPfam hit to PF05593, YD repeat, score 2.1 637910009730 chemotaxis regulator CheZ; Provisional; Region: PRK11166 637910009731 HMMPfam hit to PF04344, Chemotaxis phosphatase, CheZ, score 2.2e-144 637910009732 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 637910009733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910009734 active site 637910009735 phosphorylation site [posttranslational modification] 637910009736 intermolecular recognition site; other site 637910009737 dimerization interface [polypeptide binding]; other site 637910009738 HMMPfam hit to PF00072, Response regulator receiver, score 1.3e-47 637910009739 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 637910009740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910009741 active site 637910009742 phosphorylation site [posttranslational modification] 637910009743 intermolecular recognition site; other site 637910009744 dimerization interface [polypeptide binding]; other site 637910009745 CheB methylesterase; Region: CheB_methylest; pfam01339 637910009746 HMMPfam hit to PF01339, Chemotaxis response regulator protein-glutamate methylesterase, score 4.1e-132 637910009747 HMMPfam hit to PF00072, Response regulator receiver, score 2.5e-33 637910009748 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 637910009749 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 637910009750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910009751 S-adenosylmethionine binding site [chemical binding]; other site 637910009752 HMMPfam hit to PF01739, MCP methyltransferase, CheR-type, score 2.5e-93 637910009753 HMMPfam hit to PF03705, MCP methyltransferase, CheR-type, score 2.3e-15 637910009754 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 637910009755 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 637910009756 dimer interface [polypeptide binding]; other site 637910009757 ligand binding site [chemical binding]; other site 637910009758 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637910009759 dimerization interface [polypeptide binding]; other site 637910009760 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637910009761 dimer interface [polypeptide binding]; other site 637910009762 putative CheW interface [polypeptide binding]; other site 637910009763 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 7.7e-119 637910009764 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 2.6e-15 637910009765 2 transmembrane helices predicted for ROD19331 by TMHMM2.0 at aa 10-32 and 194-212 637910009766 HMMPfam hit to PF02203, Ligand binding Tar, score 4.6e-45 637910009767 Spore Coat Protein U domain; Region: SCPU; pfam05229 637910009768 HMMPfam hit to PF05229, Spore coat protein U, score 4.5e-13 637910009769 PapC N-terminal domain; Region: PapC_N; pfam13954 637910009770 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 637910009771 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637910009772 PapC C-terminal domain; Region: PapC_C; pfam13953 637910009773 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 9.3e-14 637910009774 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 637910009775 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 637910009776 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637910009777 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637910009778 1 transmembrane helix predicted for ROD19361 by TMHMM2.0 at aa 7-29 637910009779 Spore Coat Protein U domain; Region: SCPU; pfam05229 637910009780 HMMPfam hit to PF05229, Spore coat protein U, score 8.5e-05 637910009781 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009782 Spore Coat Protein U domain; Region: SCPU; pfam05229 637910009783 HMMPfam hit to PF05229, Spore coat protein U, score 3.5e-11 637910009784 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 637910009785 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 637910009786 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter, score 8.5e-94 637910009787 9 transmembrane helices predicted for ROD19391 by TMHMM2.0 at aa 7-29, 49-71, 84-106, 153-171, 192-214, 227-249, 294-316, 326-348 and 355-377 637910009788 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 637910009789 putative CheA interaction surface; other site 637910009790 HMMPfam hit to PF01584, CheW-like protein, score 1.9e-34 637910009791 chemotaxis protein CheA; Provisional; Region: PRK10547 637910009792 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 637910009793 putative binding surface; other site 637910009794 active site 637910009795 CheY binding; Region: CheY-binding; pfam09078 637910009796 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 637910009797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910009798 ATP binding site [chemical binding]; other site 637910009799 Mg2+ binding site [ion binding]; other site 637910009800 G-X-G motif; other site 637910009801 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 637910009802 HMMPfam hit to PF01584, CheW-like protein, score 4.9e-29 637910009803 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.4e-29 637910009804 HMMPfam hit to PF02895, Signal transducing histidine kinase, homodimeric, score 9.7e-30 637910009805 HMMPfam hit to PF09078, CheY binding, score 9.2e-30 637910009806 HMMPfam hit to PF01627, Hpt, score 2.9e-16 637910009807 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 637910009808 flagellar motor protein MotB; Validated; Region: motB; PRK09041 637910009809 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 637910009810 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637910009811 ligand binding site [chemical binding]; other site 637910009812 HMMPfam hit to PF00691, Outer membrane protein, OmpA/MotB, C-terminal, score 4.4e-37 637910009813 1 transmembrane helix predicted for ROD19421 by TMHMM2.0 at aa 29-51 637910009814 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 637910009815 flagellar motor protein MotA; Validated; Region: PRK09110 637910009816 4 transmembrane helices predicted for ROD19431 by TMHMM2.0 at aa 2-24, 34-51, 171-190 and 205-227 637910009817 PS01307 Flagellar motor protein motA family signature. 637910009818 transcriptional activator FlhC; Provisional; Region: PRK12722 637910009819 HMMPfam hit to PF05280, Flagellar transcriptional activator FlhC, score 3.2e-158 637910009820 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009821 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009822 transcriptional activator FlhD; Provisional; Region: PRK02909 637910009823 HMMPfam hit to PF05247, Flagellar transcriptional activator, score 6.1e-73 637910009824 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 637910009825 Ligand Binding Site [chemical binding]; other site 637910009826 HMMPfam hit to PF00582, UspA, score 7.3e-12 637910009827 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 637910009828 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 637910009829 active site 637910009830 homotetramer interface [polypeptide binding]; other site 637910009831 HMMPfam hit to PF00982, Glycosyl transferase, family 20, score 1.9e-209 637910009832 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 637910009833 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910009834 active site 637910009835 motif I; other site 637910009836 motif II; other site 637910009837 HMMPfam hit to PF02358, Trehalose-phosphatase, score 2.4e-74 637910009838 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637910009839 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637910009840 TM-ABC transporter signature motif; other site 637910009841 9 transmembrane helices predicted for ROD19501 by TMHMM2.0 at aa 24-46, 53-75, 102-124, 131-150, 170-192, 222-241, 251-269, 276-293 and 298-317 637910009842 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 3.6e-61 637910009843 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009844 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009845 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009846 pseudogene, truncated by frameshift mutation 637910009847 HMMPfam hit to PF00005, ABC transporter related, score 7.4e-20 637910009848 HMMPfam hit to PF00005, ABC transporter related, score 7.5e-62 637910009849 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 637910009850 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 637910009851 ligand binding site [chemical binding]; other site 637910009852 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 2.7e-144 637910009853 DJ-1 family protein; Region: not_thiJ; TIGR01383 637910009854 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 637910009855 conserved cys residue [active] 637910009856 HMMPfam hit to PF01965, ThiJ/PfpI, score 5.3e-20 637910009857 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 637910009858 Ferritin-like domain; Region: Ferritin; pfam00210 637910009859 ferroxidase diiron center [ion binding]; other site 637910009860 HMMPfam hit to PF00210, Ferritin and Dps, score 4.3e-23 637910009861 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 637910009862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910009863 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637910009864 putative substrate translocation pore; other site 637910009865 14 transmembrane helices predicted for ROD19571 by TMHMM2.0 at aa 13-35, 55-75, 82-104, 108-130, 137-159, 169-191, 204-226, 230-252, 272-294, 309-331, 336-355, 365-387, 400-422 and 437-456 637910009866 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 2.7e-50 637910009867 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009868 hypothetical protein; Provisional; Region: PRK09273 637910009869 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 637910009870 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 637910009871 HMMPfam hit to PF02502, Ribose/galactose isomerase, score 2.9e-37 637910009872 YecR-like lipoprotein; Region: YecR; pfam13992 637910009873 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009874 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 637910009875 Ferritin-like domain; Region: Ferritin; pfam00210 637910009876 ferroxidase diiron center [ion binding]; other site 637910009877 HMMPfam hit to PF00210, Ferritin and Dps, score 2.5e-42 637910009878 probable metal-binding protein; Region: matur_matur; TIGR03853 637910009879 tyrosine transporter TyrP; Provisional; Region: PRK15132 637910009880 aromatic amino acid transport protein; Region: araaP; TIGR00837 637910009881 HMMPfam hit to PF03222, Aromatic amino acid permease, score 1.1e-205 637910009882 11 transmembrane helices predicted for ROD19621 by TMHMM2.0 at aa 7-29, 33-55, 81-103, 113-135, 148-170, 185-207, 214-236, 273-295, 308-330, 335-357 and 377-399 637910009883 PS00594 Aromatic amino acids permeases signature. 637910009884 hypothetical protein; Provisional; Region: PRK10396 637910009885 yecA family protein; Region: ygfB_yecA; TIGR02292 637910009886 SEC-C motif; Region: SEC-C; pfam02810 637910009887 HMMPfam hit to PF02810, SEC-C motif, score 7.4e-07 637910009888 PS00294 Prenyl group binding site (CAAX box). 637910009889 anti-adapter protein IraM; Provisional; Region: PRK09919 637910009890 PS00027 'Homeobox' domain signature. 637910009891 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910009892 Helix-turn-helix domain; Region: HTH_28; pfam13518 637910009893 Predicted helix-turn-helix motif with score 1716.000, SD 5.03 at aa 21-42, sequence EGQEATAKRFGIDHSAVRKWTA 637910009894 PS00294 Prenyl group binding site (CAAX box). 637910009895 putative transposase OrfB; Reviewed; Region: PHA02517 637910009896 HTH-like domain; Region: HTH_21; pfam13276 637910009897 Integrase core domain; Region: rve; pfam00665 637910009898 Integrase core domain; Region: rve_2; pfam13333 637910009899 HMMPfam hit to PF00665, Integrase, catalytic core, score 1.6e-36 637910009900 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 637910009901 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 3.2e-47 637910009902 3 transmembrane helices predicted for ROD19671 by TMHMM2.0 at aa 7-26, 30-52 and 147-169 637910009903 PS00379 CDP-alcohol phosphatidyltransferases signature. 637910009904 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 637910009905 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 637910009906 GIY-YIG motif/motif A; other site 637910009907 active site 637910009908 catalytic site [active] 637910009909 putative DNA binding site [nucleotide binding]; other site 637910009910 metal binding site [ion binding]; metal-binding site 637910009911 UvrB/uvrC motif; Region: UVR; pfam02151 637910009912 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 637910009913 Helix-hairpin-helix motif; Region: HHH; pfam00633 637910009914 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 4.9e-07 637910009915 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 5.8e-07 637910009916 HMMPfam hit to PF08459, Excinuclease ABC, C subunit, C-terminal, score 8.6e-92 637910009917 HMMPfam hit to PF02151, UvrB/UvrC protein, score 3.8e-11 637910009918 HMMPfam hit to PF01541, Excinuclease ABC, C subunit, N-terminal, score 6.9e-32 637910009919 response regulator; Provisional; Region: PRK09483 637910009920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910009921 active site 637910009922 phosphorylation site [posttranslational modification] 637910009923 intermolecular recognition site; other site 637910009924 dimerization interface [polypeptide binding]; other site 637910009925 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910009926 DNA binding residues [nucleotide binding] 637910009927 dimerization interface [polypeptide binding]; other site 637910009928 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 5.3e-27 637910009929 PS00622 Bacterial regulatory proteins, luxR family signature. 637910009930 HMMPfam hit to PF00072, Response regulator receiver, score 6.2e-45 637910009931 hypothetical protein; Provisional; Region: PRK10613 637910009932 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 637910009933 Autoinducer binding domain; Region: Autoind_bind; pfam03472 637910009934 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910009935 DNA binding residues [nucleotide binding] 637910009936 dimerization interface [polypeptide binding]; other site 637910009937 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 2.4e-25 637910009938 PS00622 Bacterial regulatory proteins, luxR family signature. 637910009939 Predicted helix-turn-helix motif with score 1338.000, SD 3.74 at aa 195-216, sequence KTSYEIAMILSISENTVNFHQK 637910009940 HMMPfam hit to PF03472, Autoinducer-binding, score 3.3e-46 637910009941 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 637910009942 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637910009943 Walker A/P-loop; other site 637910009944 ATP binding site [chemical binding]; other site 637910009945 Q-loop/lid; other site 637910009946 ABC transporter signature motif; other site 637910009947 Walker B; other site 637910009948 D-loop; other site 637910009949 H-loop/switch region; other site 637910009950 HMMPfam hit to PF00005, ABC transporter related, score 3.7e-71 637910009951 PS00211 ABC transporters family signature. 637910009952 PS00017 ATP/GTP-binding site motif A (P-loop). 637910009953 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 637910009954 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637910009955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910009956 dimer interface [polypeptide binding]; other site 637910009957 conserved gate region; other site 637910009958 putative PBP binding loops; other site 637910009959 ABC-ATPase subunit interface; other site 637910009960 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.5e-35 637910009961 3 transmembrane helices predicted for ROD19731 by TMHMM2.0 at aa 20-42, 54-76 and 185-207 637910009962 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910009963 D-cysteine desulfhydrase; Validated; Region: PRK03910 637910009964 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 637910009965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910009966 catalytic residue [active] 637910009967 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 7e-09 637910009968 cystine transporter subunit; Provisional; Region: PRK11260 637910009969 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637910009970 substrate binding pocket [chemical binding]; other site 637910009971 membrane-bound complex binding site; other site 637910009972 hinge residues; other site 637910009973 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 9.7e-102 637910009974 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 637910009975 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 637910009976 HMMPfam hit to PF02899, Integrase, N-terminal SAM-like, phage, score 1.9e-10 637910009977 PS00190 Cytochrome c family heme-binding site signature. 637910009978 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 637910009979 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637910009980 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 637910009981 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637910009982 DNA binding residues [nucleotide binding] 637910009983 HMMPfam hit to PF04545, RNA polymerase sigma-70 region 4, score 1.1e-19 637910009984 PS00716 Sigma-70 factors family signature 2. 637910009985 Predicted helix-turn-helix motif with score 1242.000, SD 3.42 at aa 205-226, sequence LNLKEIGAVLEVGESRVSQLHS 637910009986 HMMPfam hit to PF04539, RNA polymerase sigma-70 region 3, score 5.1e-22 637910009987 HMMPfam hit to PF04542, RNA polymerase sigma-70 region 2, score 5.2e-19 637910009988 PS00715 Sigma-70 factors family signature 1. 637910009989 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910009990 pseudogene, disrupted by prophage CRP20 insertion 637910009991 prophage remnant CRPr20 637910009992 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 637910009993 DNA methylase; Region: N6_N4_Mtase; pfam01555 637910009994 HMMPfam hit to PF01555, DNA methylase N-4/N-6, score 1.2e-26 637910009995 PS00092 N-6 Adenine-specific DNA methylases signature. 637910009996 Mu-like prophage protein Com [General function prediction only]; Region: Com; COG4416 637910009997 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 637910009998 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 637910009999 2 transmembrane helices predicted for ROD19801 by TMHMM2.0 at aa 37-56 and 63-85 637910010000 HMMPfam hit to PF05154, TM2, score 2.5e-18 637910010001 Hok/gef family; Region: HOK_GEF; pfam01848 637910010002 1 transmembrane helix predicted for ROD19811 by TMHMM2.0 at aa 5-27 637910010003 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 637910010004 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 637910010005 HMMPfam hit to PF04606, Phage transcriptional activator, Ogr/Delta, score 1.3e-12 637910010006 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 637910010007 HMMPfam hit to PF05954, Phage late control D, score 7.6e-128 637910010008 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 637910010009 HMMPfam hit to PF04984, Phage tail sheath protein, score 4e-87 637910010010 Phage tail tube protein FII; Region: Phage_tube; cl01390 637910010011 HMMPfam hit to PF04985, Phage major tail tube protein, score 4.4e-51 637910010012 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 637910010013 HMMPfam hit to PF06158, Phage tail E, score 2.8e-44 637910010014 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 637910010015 HMMPfam hit to PF06528, Phage P2 GpE, score 6.3e-23 637910010016 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 637910010017 PS00215 Mitochondrial energy transfer proteins signature. 637910010018 3 transmembrane helices predicted for ROD19881 by TMHMM2.0 at aa 529-551, 558-580 and 590-612 637910010019 Predicted helix-turn-helix motif with score 974.000, SD 2.50 at aa 642-663, sequence ERFGPVFDAVGSGISQVFNWFK 637910010020 Phage protein U [General function prediction only]; Region: COG3499 637910010021 HMMPfam hit to PF06995, Phage P2 GpU, score 8.8e-76 637910010022 multiple promoter invertase; Provisional; Region: mpi; PRK13413 637910010023 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 637910010024 catalytic residues [active] 637910010025 catalytic nucleophile [active] 637910010026 Presynaptic Site I dimer interface [polypeptide binding]; other site 637910010027 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 637910010028 Synaptic Flat tetramer interface [polypeptide binding]; other site 637910010029 Synaptic Site I dimer interface [polypeptide binding]; other site 637910010030 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637910010031 DNA-binding interface [nucleotide binding]; DNA binding site 637910010032 HMMPfam hit to PF02796, Resolvase, helix-turn-helix region, score 1.8e-12 637910010033 Predicted helix-turn-helix motif with score 1793.000, SD 5.29 at aa 159-180, sequence HDRKQLAIIYGIGTSTIYRYHP 637910010034 HMMPfam hit to PF00239, Resolvase, N-terminal, score 6.6e-73 637910010035 PS00398 Site-specific recombinases signature 2. 637910010036 PS00397 Site-specific recombinases active site. 637910010037 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 637910010038 HMMPfam hit to PF05840, Bacteriophage replication gene A, score 4.6e-149 637910010039 Ash protein family; Region: Phage_ASH; pfam10554 637910010040 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 637910010041 SPFH domain / Band 7 family; Region: Band_7; pfam01145 637910010042 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 637910010043 HMMPfam hit to PF01145, Band 7 protein, score 2.8e-05 637910010044 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010045 2 transmembrane helices predicted for ROD19951 by TMHMM2.0 at aa 5-27 and 37-59 637910010046 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637910010047 MarR family; Region: MarR_2; pfam12802 637910010048 1 transmembrane helix predicted for ROD20001 by TMHMM2.0 at aa 4-26 637910010049 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010050 1 transmembrane helix predicted for ROD20041 by TMHMM2.0 at aa 42-64 637910010051 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637910010052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637910010053 non-specific DNA binding site [nucleotide binding]; other site 637910010054 salt bridge; other site 637910010055 sequence-specific DNA binding site [nucleotide binding]; other site 637910010056 integrase; Provisional; Region: int; PHA02601 637910010057 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637910010058 active site 637910010059 DNA binding site [nucleotide binding] 637910010060 Int/Topo IB signature motif; other site 637910010061 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 2.3e-29 637910010062 HMMPfam hit to PF00700, Flagellin, C-terminal, score 3.6e-37 637910010063 HMMPfam hit to PF08884, Flagellin D3, score 5.5e-08 637910010064 HMMPfam hit to PF00669, Flagellin, N-terminal, score 1.5e-79 637910010065 flagellar capping protein; Reviewed; Region: fliD; PRK08032 637910010066 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 637910010067 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 637910010068 HMMPfam hit to PF02465, Flagellar hook-associated protein 2, N-terminal, score 7.2e-31 637910010069 HMMPfam hit to PF07196, Flagellin hook IN, score 5.1e-07 637910010070 HMMPfam hit to PF07195, Flagellar hook-associated 2, C-terminal, score 1.2e-77 637910010071 PS00017 ATP/GTP-binding site motif A (P-loop). 637910010072 flagellar protein FliS; Validated; Region: fliS; PRK05685 637910010073 HMMPfam hit to PF02561, Flagellar protein FliS, score 1.4e-54 637910010074 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 637910010075 HMMPfam hit to PF05400, Flagellar export chaperone, score 1.5e-73 637910010076 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 637910010077 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 637910010078 active site 637910010079 Na/Ca binding site [ion binding]; other site 637910010080 catalytic site [active] 637910010081 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 1.5e-85 637910010082 HMMPfam hit to PF02806, Alpha-amylase, C-terminal all beta, score 6.7e-05 637910010083 lipoprotein; Provisional; Region: PRK10397 637910010084 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010085 putative inner membrane protein; Provisional; Region: PRK11099 637910010086 Sulphur transport; Region: Sulf_transp; pfam04143 637910010087 10 transmembrane helices predicted for ROD20131 by TMHMM2.0 at aa 12-34, 81-103, 116-138, 148-170, 197-216, 221-240, 260-282, 286-308, 321-340 and 360-382 637910010088 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010089 HMMPfam hit to PF04143, Protein of unknown function DUF395, YeeE/YedE, score 1.3e-18 637910010090 HMMPfam hit to PF04143, Protein of unknown function DUF395, YeeE/YedE, score 7.3e-21 637910010091 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010092 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 637910010093 CPxP motif; other site 637910010094 HMMPfam hit to PF01206, SirA-like, score 6.7e-43 637910010095 PS01148 Uncharacterized protein family UPF0033 signature. 637910010096 outer membrane protease; Reviewed; Region: PRK10993 637910010097 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010098 HMMPfam hit to PF01278, Peptidase A26, omptin, score 6e-191 637910010099 PS00834 Serine proteases, omptin family signature 1. 637910010100 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010101 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010102 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 637910010103 HMMPfam hit to PF02049, Flagellar hook-basal body complex protein FliE, score 4.1e-48 637910010104 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 637910010105 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 637910010106 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 637910010107 HMMPfam hit to PF01514, Secretory protein YscJ/FliF, score 2e-93 637910010108 1 transmembrane helix predicted for ROD20181 by TMHMM2.0 at aa 26-45 637910010109 HMMPfam hit to PF08345, Flagellar M-ring C-terminal, score 2.7e-88 637910010110 flagellar motor switch protein FliG; Region: fliG; TIGR00207 637910010111 FliG C-terminal domain; Region: FliG_C; pfam01706 637910010112 HMMPfam hit to PF01706, Flagellar motor switch protein FliG, score 2e-62 637910010113 flagellar assembly protein H; Validated; Region: fliH; PRK05687 637910010114 Flagellar assembly protein FliH; Region: FliH; pfam02108 637910010115 HMMPfam hit to PF02108, Flagellar assembly protein FliH, score 4.3e-130 637910010116 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 637910010117 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 637910010118 Walker A motif/ATP binding site; other site 637910010119 Walker B motif; other site 637910010120 HMMPfam hit to PF00006, ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding, score 1.3e-120 637910010121 PS00017 ATP/GTP-binding site motif A (P-loop). 637910010122 PS00152 ATP synthase alpha and beta subunits signature. 637910010123 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 637910010124 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 637910010125 HMMPfam hit to PF02050, Flagellar FliJ protein, score 8.1e-116 637910010126 flagellar hook-length control protein; Provisional; Region: PRK10118 637910010127 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 637910010128 HMMPfam hit to PF02120, Flagellar hook-length control protein, score 5.6e-42 637910010129 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 637910010130 HMMPfam hit to PF03748, Flagellar basal body-associated protein FliL, score 1.1e-48 637910010131 1 transmembrane helix predicted for ROD20241 by TMHMM2.0 at aa 13-35 637910010132 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010133 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 637910010134 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 637910010135 HMMPfam hit to PF02154, Flagellar motor switch protein FliM, score 2.5e-124 637910010136 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) protein, score 0.16 637910010137 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 637910010138 flagellar motor switch protein; Validated; Region: fliN; PRK05698 637910010139 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) protein, score 2.8e-36 637910010140 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 637910010141 1 transmembrane helix predicted for ROD20271 by TMHMM2.0 at aa 21-39 637910010142 HMMPfam hit to PF04347, Flagellar biosynthesis protein, FliO, score 1.1e-38 637910010143 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 637910010144 5 transmembrane helices predicted for ROD20281 by TMHMM2.0 at aa 9-31, 46-68, 88-105, 185-207 and 214-236 637910010145 HMMPfam hit to PF00813, type III secretion system inner membrane P protein, score 2.7e-126 637910010146 PS01060 Flagella transport protein fliP family signature 1. 637910010147 PS01061 Flagella transport protein fliP family signature 2. 637910010148 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 637910010149 HMMPfam hit to PF01313, Bacterial export protein FliQ, family 3, score 1.5e-40 637910010150 2 transmembrane helices predicted for ROD20291 by TMHMM2.0 at aa 20-42 and 52-74 637910010151 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 637910010152 HMMPfam hit to PF01311, type III secretion system inner membrane R protein, score 3e-90 637910010153 6 transmembrane helices predicted for ROD20301 by TMHMM2.0 at aa 15-37, 44-63, 73-95, 132-154, 169-191 and 211-233 637910010154 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 637910010155 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910010156 DNA binding residues [nucleotide binding] 637910010157 dimerization interface [polypeptide binding]; other site 637910010158 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 3.6e-22 637910010159 PS00622 Bacterial regulatory proteins, luxR family signature. 637910010160 hypothetical protein; Provisional; Region: PRK10708 637910010161 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 637910010162 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 637910010163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910010164 active site 637910010165 motif I; other site 637910010166 motif II; other site 637910010167 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 6.4e-09 637910010168 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 637910010169 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637910010170 metal binding site [ion binding]; metal-binding site 637910010171 active site 637910010172 I-site; other site 637910010173 HMMPfam hit to PF00990, GGDEF, score 1.1e-66 637910010174 2 transmembrane helices predicted for ROD20351 by TMHMM2.0 at aa 20-42 and 358-380 637910010175 Uncharacterized small protein [Function unknown]; Region: COG5475 637910010176 Protein of unknown function (DUF808); Region: DUF808; cl01002 637910010177 HMMPfam hit to PF05661, Protein of unknown function DUF808, score 2e-160 637910010178 4 transmembrane helices predicted for ROD20371 by TMHMM2.0 at aa 49-71, 151-173, 208-230 and 245-267 637910010179 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 637910010180 EamA-like transporter family; Region: EamA; pfam00892 637910010181 10 transmembrane helices predicted for ROD20381 by TMHMM2.0 at aa 7-29, 39-56, 68-87, 97-119, 126-143, 148-170, 177-199, 212-234, 241-260 and 270-292 637910010182 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 1.3e-27 637910010183 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 3.7e-16 637910010184 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 637910010185 additional DNA contacts [nucleotide binding]; other site 637910010186 mismatch recognition site; other site 637910010187 active site 637910010188 zinc binding site [ion binding]; other site 637910010189 DNA intercalation site [nucleotide binding]; other site 637910010190 HMMPfam hit to PF03852, DNA mismatch endonuclease vsr, score 1.1e-42 637910010191 DNA cytosine methylase; Provisional; Region: PRK10458 637910010192 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 637910010193 cofactor binding site; other site 637910010194 DNA binding site [nucleotide binding] 637910010195 substrate interaction site [chemical binding]; other site 637910010196 HMMPfam hit to PF00145, C-5 cytosine-specific DNA methylase, score 9.3e-89 637910010197 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 637910010198 PS00094 C-5 cytosine-specific DNA methylases active site. 637910010199 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 637910010200 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637910010201 Zn2+ binding site [ion binding]; other site 637910010202 Mg2+ binding site [ion binding]; other site 637910010203 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 7.4e-16 637910010204 2 transmembrane helices predicted for ROD20421 by TMHMM2.0 at aa 19-41 and 65-87 637910010205 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 637910010206 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 637910010207 trimer interface [polypeptide binding]; other site 637910010208 eyelet of channel; other site 637910010209 HMMPfam hit to PF00267, Porin, Gram-negative type, score 7.1e-216 637910010210 PS00576 General diffusion Gram-negative porins signature. 637910010211 CR_GI5 637910010212 integrase; Provisional; Region: PRK09692 637910010213 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 637910010214 active site 637910010215 Int/Topo IB signature motif; other site 637910010216 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 4.9e-21 637910010217 4 transmembrane helices predicted for ROD20451 by TMHMM2.0 at aa 30-52, 67-89, 155-172 and 195-217 637910010218 Conjugal transfer protein TraD; Region: TraD; pfam06412 637910010219 4 transmembrane helices predicted for ROD20471 by TMHMM2.0 at aa 16-38, 48-65, 77-99 and 114-136 637910010220 2 transmembrane helices predicted for ROD20481 by TMHMM2.0 at aa 11-28 and 43-65 637910010221 MobA/MobL family; Region: MobA_MobL; pfam03389 637910010222 HMMPfam hit to PF03389, MobA/MobL protein, score 1.4e-40 637910010223 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 637910010224 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010225 1 transmembrane helix predicted for ROD20521 by TMHMM2.0 at aa 10-27 637910010226 pseudogene, truncated by premature stop codon 637910010227 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 637910010228 active site 637910010229 GIY-YIG motif/motif A; other site 637910010230 catalytic site [active] 637910010231 metal binding site [ion binding]; metal-binding site 637910010232 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 637910010233 GIY-YIG motif/motif A; other site 637910010234 active site 637910010235 catalytic site [active] 637910010236 metal binding site [ion binding]; metal-binding site 637910010237 HMMPfam hit to PF01541, Excinuclease ABC, C subunit, N-terminal, score 0.0039 637910010238 Predicted helix-turn-helix motif with score 1160.000, SD 3.14 at aa 103-124, sequence ISQAKLCRDLDIKKSNMSIVFT 637910010239 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 637910010240 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 637910010241 HMMPfam hit to PF00816, Histone-like nucleoid-structuring protein H-NS, score 1.4e-37 637910010242 PS00017 ATP/GTP-binding site motif A (P-loop). 637910010243 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 637910010244 HMMPfam hit to PF05930, Prophage CP4-57 regulatory, score 4.6e-24 637910010245 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 637910010246 HMMPfam hit to PF06167, Protein of unknown function DUF980, score 1.6e-145 637910010247 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 637910010248 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 637910010249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910010250 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 637910010251 putative substrate binding site [chemical binding]; other site 637910010252 dimerization interface [polypeptide binding]; other site 637910010253 HMMPfam hit to PF03466, LysR, substrate-binding, score 3.8e-47 637910010254 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 5.7e-16 637910010255 PS00044 Bacterial regulatory proteins, lysR family signature. 637910010256 Predicted helix-turn-helix motif with score 1732.000, SD 5.09 at aa 17-38, sequence YNLTEVASMLYTSQSGVSRHIR 637910010257 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 637910010258 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910010259 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 637910010260 putative dimerization interface [polypeptide binding]; other site 637910010261 HMMPfam hit to PF03466, LysR, substrate-binding, score 7.7e-35 637910010262 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 7.3e-21 637910010263 PS00044 Bacterial regulatory proteins, lysR family signature. 637910010264 Predicted helix-turn-helix motif with score 1549.000, SD 4.46 at aa 16-37, sequence GSLTQAAEVLHIAQPALSQQVA 637910010265 integrase; Provisional; Region: PRK09692 637910010266 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 637910010267 active site 637910010268 Int/Topo IB signature motif; other site 637910010269 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 6e-27 637910010270 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 637910010271 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910010272 HMMPfam hit to PF01609, Transposase, IS4-like, score 9.3e-30 637910010273 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 637910010274 Integrase; Region: Integrase_1; pfam12835 637910010275 Predicted helix-turn-helix motif with score 992.000, SD 2.57 at aa 6-27, sequence QEMKRLAQQAGGSHKTVHDRIK 637910010276 pseudogene, N-terminus missing, fragment 637910010277 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 637910010278 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 637910010279 4 transmembrane helices predicted for ROD20801 by TMHMM2.0 at aa 23-45, 49-71, 101-123 and 143-165 637910010280 Autotransporter beta-domain; Region: Autotransporter; cl17461 637910010281 HMMPfam hit to PF03797, Autotransporter beta-domain, score 2e-06 637910010282 PS00192 Cytochrome b/b6 heme-ligand signature. 637910010283 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 637910010284 Fatty acid desaturase; Region: FA_desaturase; pfam00487 637910010285 putative di-iron ligands [ion binding]; other site 637910010286 4 transmembrane helices predicted for ROD20821 by TMHMM2.0 at aa 7-24, 29-51, 122-144 and 191-213 637910010287 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010288 HMMPfam hit to PF00487, Fatty acid desaturase, type 1, score 0.00068 637910010289 1 transmembrane helix predicted for ROD20831 by TMHMM2.0 at aa 156-175 637910010290 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 637910010291 active site 637910010292 HMMPfam hit to PF01569, Phosphatidic acid phosphatase type 2-like, score 6.5e-10 637910010293 6 transmembrane helices predicted for ROD20841 by TMHMM2.0 at aa 12-34, 54-76, 83-105, 132-149, 156-175 and 180-197 637910010294 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 637910010295 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 637910010296 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910010297 FeS/SAM binding site; other site 637910010298 HMMPfam hit to PF04055, Radical SAM, score 3.7e-09 637910010299 HMMPfam hit to PF02310, Cobalamin (vitamin B12)-binding, score 2.2e-07 637910010300 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 637910010301 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 637910010302 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910010303 FeS/SAM binding site; other site 637910010304 HMMPfam hit to PF04055, Radical SAM, score 1.1e-17 637910010305 HMMPfam hit to PF02310, Cobalamin (vitamin B12)-binding, score 4.4e-08 637910010306 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 637910010307 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 637910010308 B12 binding site [chemical binding]; other site 637910010309 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910010310 FeS/SAM binding site; other site 637910010311 HMMPfam hit to PF04055, Radical SAM, score 4e-14 637910010312 HMMPfam hit to PF02310, Cobalamin (vitamin B12)-binding, score 2.6e-06 637910010313 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 637910010314 B12 binding site [chemical binding]; other site 637910010315 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 637910010316 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910010317 FeS/SAM binding site; other site 637910010318 HMMPfam hit to PF04055, Radical SAM, score 4.4e-11 637910010319 HMMPfam hit to PF02310, Cobalamin (vitamin B12)-binding, score 6.6e-06 637910010320 GH3 auxin-responsive promoter; Region: GH3; pfam03321 637910010321 HMMPfam hit to PF03321, GH3 auxin-responsive promoter, score 1.3e-09 637910010322 shikimate transporter; Provisional; Region: PRK09952 637910010323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910010324 putative substrate translocation pore; other site 637910010325 12 transmembrane helices predicted for ROD20931 by TMHMM2.0 at aa 26-48, 63-85, 97-119, 129-151, 164-186, 196-215, 255-277, 287-309, 318-337, 341-363, 383-405 and 409-431 637910010326 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 8.8e-24 637910010327 PS00217 Sugar transport proteins signature 2. 637910010328 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010329 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010330 AMP nucleosidase; Provisional; Region: PRK08292 637910010331 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 637910010332 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 637910010333 HMMPfam hit to PF01048, Nucleoside phosphorylase, score 3e-91 637910010334 MATE family multidrug exporter; Provisional; Region: PRK10189 637910010335 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 637910010336 11 transmembrane helices predicted for ROD20951 by TMHMM2.0 at aa 48-70, 85-107, 120-142, 157-179, 192-214, 234-256, 263-285, 295-317, 351-373, 388-410 and 433-455 637910010337 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 1.7e-40 637910010338 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 8.1e-42 637910010339 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910010340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910010341 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 637910010342 dimerization interface [polypeptide binding]; other site 637910010343 HMMPfam hit to PF03466, LysR, substrate-binding, score 8.5e-06 637910010344 PS00435 Peroxidases proximal heme-ligand signature. 637910010345 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 4.1e-19 637910010346 PS00044 Bacterial regulatory proteins, lysR family signature. 637910010347 Predicted helix-turn-helix motif with score 1223.000, SD 3.35 at aa 16-37, sequence GNYSLAATARHITQPALSRRIK 637910010348 isoaspartyl dipeptidase; Provisional; Region: PRK10657 637910010349 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 637910010350 active site 637910010351 HMMPfam hit to PF01979, Amidohydrolase 1, score 0.00035 637910010352 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 637910010353 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 1.1e-76 637910010354 11 transmembrane helices predicted for ROD20991 by TMHMM2.0 at aa 5-20, 27-49, 80-102, 115-137, 195-217, 249-271, 314-336, 348-370, 406-428, 441-458 and 462-479 637910010355 L,D-transpeptidase; Provisional; Region: PRK10190 637910010356 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 637910010357 HMMPfam hit to PF03734, ErfK/YbiS/YcfS/YnhG, score 2.6e-64 637910010358 1 transmembrane helix predicted for ROD21001 by TMHMM2.0 at aa 5-27 637910010359 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 637910010360 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 637910010361 putative dimer interface [polypeptide binding]; other site 637910010362 active site pocket [active] 637910010363 putative cataytic base [active] 637910010364 HMMPfam hit to PF02277, Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase-like, core, score 1.2e-171 637910010365 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010366 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010367 cobalamin synthase; Reviewed; Region: cobS; PRK00235 637910010368 HMMPfam hit to PF02654, Cobalamin (vitamin B12) biosynthesis CobS, cobalamin-5-phosphate synthase, score 9.8e-101 637910010369 6 transmembrane helices predicted for ROD21021 by TMHMM2.0 at aa 33-55, 59-81, 109-131, 136-158, 171-193 and 197-219 637910010370 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010371 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 637910010372 homotrimer interface [polypeptide binding]; other site 637910010373 Walker A motif; other site 637910010374 GTP binding site [chemical binding]; other site 637910010375 Walker B motif; other site 637910010376 HMMPfam hit to PF02283, Cobinamide kinase/cobinamide phosphate guanyltransferase, score 6.3e-104 637910010377 PS00017 ATP/GTP-binding site motif A (P-loop). 637910010378 cobyric acid synthase; Provisional; Region: PRK00784 637910010379 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 637910010380 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 637910010381 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 637910010382 catalytic triad [active] 637910010383 HMMPfam hit to PF07685, CobB/CobQ-like glutamine amidotransferase, score 4.2e-66 637910010384 HMMPfam hit to PF01656, Cobyrinic acid a,c-diamide synthase, score 1.5e-59 637910010385 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 637910010386 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 637910010387 Walker A/P-loop; other site 637910010388 ATP binding site [chemical binding]; other site 637910010389 Q-loop/lid; other site 637910010390 ABC transporter signature motif; other site 637910010391 Walker B; other site 637910010392 D-loop; other site 637910010393 H-loop/switch region; other site 637910010394 HMMPfam hit to PF00005, ABC transporter related, score 1.1e-63 637910010395 PS00211 ABC transporters family signature. 637910010396 PS00017 ATP/GTP-binding site motif A (P-loop). 637910010397 cobalt transport protein CbiQ; Provisional; Region: PRK15485 637910010398 HMMPfam hit to PF02361, Cobalt transport protein, score 1.6e-51 637910010399 6 transmembrane helices predicted for ROD21061 by TMHMM2.0 at aa 23-43, 63-85, 92-111, 121-143, 156-174 and 189-206 637910010400 cobalt transport protein CbiN; Provisional; Region: PRK02898 637910010401 2 transmembrane helices predicted for ROD21071 by TMHMM2.0 at aa 5-22 and 60-82 637910010402 HMMPfam hit to PF02553, Cobalt transport protein CbiN, score 1e-40 637910010403 cobalt transport protein CbiM; Validated; Region: PRK08319 637910010404 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 637910010405 HMMPfam hit to PF01891, Cobalamin (vitamin B12) biosynthesis CbiM, score 9e-95 637910010406 6 transmembrane helices predicted for ROD21081 by TMHMM2.0 at aa 12-31, 36-58, 103-125, 135-157, 169-188 and 208-230 637910010407 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 637910010408 active site 637910010409 SAM binding site [chemical binding]; other site 637910010410 homodimer interface [polypeptide binding]; other site 637910010411 HMMPfam hit to PF00590, Tetrapyrrole methylase, score 2.2e-56 637910010412 PS00840 Uroporphyrin-III C-methyltransferase signature 2. 637910010413 PS00839 Uroporphyrin-III C-methyltransferase signature 1. 637910010414 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 637910010415 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 637910010416 active site 637910010417 C-terminal domain interface [polypeptide binding]; other site 637910010418 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 637910010419 active site 637910010420 N-terminal domain interface [polypeptide binding]; other site 637910010421 HMMPfam hit to PF06180, Anaerobic cobalt chelatase, score 5e-160 637910010422 PS00761 Signal peptidases I signature 3. 637910010423 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010424 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 637910010425 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 637910010426 HMMPfam hit to PF02571, Cobalamin (vitamin B12) biosynthesis CobK/CbiJ, precorrin-6x reductase, score 7.2e-42 637910010427 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 637910010428 active site 637910010429 SAM binding site [chemical binding]; other site 637910010430 homodimer interface [polypeptide binding]; other site 637910010431 HMMPfam hit to PF00590, Tetrapyrrole methylase, score 7.6e-77 637910010432 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 637910010433 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 637910010434 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 637910010435 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 637910010436 HMMPfam hit to PF01890, Cobalamin (vitamin B12) biosynthesis CbiG, core, score 9.9e-136 637910010437 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 637910010438 active site 637910010439 SAM binding site [chemical binding]; other site 637910010440 homodimer interface [polypeptide binding]; other site 637910010441 HMMPfam hit to PF00590, Tetrapyrrole methylase, score 1.1e-76 637910010442 PS00840 Uroporphyrin-III C-methyltransferase signature 2. 637910010443 PS00017 ATP/GTP-binding site motif A (P-loop). 637910010444 PS00839 Uroporphyrin-III C-methyltransferase signature 1. 637910010445 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 637910010446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910010447 S-adenosylmethionine binding site [chemical binding]; other site 637910010448 PS00012 Phosphopantetheine attachment site. 637910010449 HMMPfam hit to PF08242, Methyltransferase type 12, score 2.3e-05 637910010450 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 637910010451 active site 637910010452 putative homodimer interface [polypeptide binding]; other site 637910010453 SAM binding site [chemical binding]; other site 637910010454 HMMPfam hit to PF00590, Tetrapyrrole methylase, score 1.1e-47 637910010455 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 637910010456 HMMPfam hit to PF01888, Cobalamin (vitamin B12) biosynthesis CbiD, score 1.2e-173 637910010457 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 637910010458 Precorrin-8X methylmutase; Region: CbiC; pfam02570 637910010459 HMMPfam hit to PF02570, Cobalamin (vitamin B12) biosynthesis CobH/CbiC, precorrin-8X methylmutase, core, score 1.4e-39 637910010460 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 637910010461 5 transmembrane helices predicted for ROD21191 by TMHMM2.0 at aa 52-74, 79-101, 155-177, 207-224 and 294-316 637910010462 HMMPfam hit to PF03186, Cobalamin (vitamin B12) biosynthesis CbiB, score 1.1e-154 637910010463 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 637910010464 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 637910010465 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 637910010466 HMMPfam hit to PF01656, Cobyrinic acid a,c-diamide synthase, score 5.9e-52 637910010467 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010468 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 637910010469 Sensory domain found in PocR; Region: PocR; pfam10114 637910010470 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910010471 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637910010472 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910010473 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 1.3e-14 637910010474 PS00041 Bacterial regulatory proteins, araC family signature. 637910010475 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 9.6e-14 637910010476 Predicted helix-turn-helix motif with score 1209.000, SD 3.30 at aa 211-232, sequence LRLEDVASHVYLSPYYFSKLFK 637910010477 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 637910010478 amphipathic channel; other site 637910010479 Asn-Pro-Ala signature motifs; other site 637910010480 6 transmembrane helices predicted for ROD21221 by TMHMM2.0 at aa 10-32, 37-59, 89-111, 140-162, 177-199 and 231-253 637910010481 HMMPfam hit to PF00230, major intrinsic protein, score 2.3e-89 637910010482 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010483 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010484 PS00221 MIP family signature. 637910010485 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010486 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 637910010487 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 637910010488 Hexamer interface [polypeptide binding]; other site 637910010489 Putative hexagonal pore residue; other site 637910010490 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 1e-40 637910010491 PS01139 Bacterial microcompartiments proteins signature. 637910010492 propanediol utilization protein PduB; Provisional; Region: PRK15415 637910010493 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 637910010494 putative hexamer interface [polypeptide binding]; other site 637910010495 putative hexagonal pore; other site 637910010496 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 637910010497 putative hexamer interface [polypeptide binding]; other site 637910010498 putative hexagonal pore; other site 637910010499 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 5.9e-18 637910010500 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 3.8e-17 637910010501 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 637910010502 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 637910010503 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 637910010504 alpha-beta subunit interface [polypeptide binding]; other site 637910010505 alpha-gamma subunit interface [polypeptide binding]; other site 637910010506 active site 637910010507 substrate and K+ binding site; other site 637910010508 K+ binding site [ion binding]; other site 637910010509 cobalamin binding site [chemical binding]; other site 637910010510 HMMPfam hit to PF02286, Dehydratase, large subunit, score 0 637910010511 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010512 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 637910010513 HMMPfam hit to PF02288, Dehydratase, medium subunit, score 4.2e-124 637910010514 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 637910010515 HMMPfam hit to PF02287, Dehydratase, small subunit, score 9.1e-102 637910010516 Cell division protein FtsA; Region: FtsA; cl17206 637910010517 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 637910010518 HMMPfam hit to PF08841, Diol/glycerol dehydratase reactivating factor, large subunit, score 0 637910010519 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 637910010520 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 637910010521 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 637910010522 Hexamer interface [polypeptide binding]; other site 637910010523 Putative hexagonal pore residue; other site 637910010524 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 5.9e-42 637910010525 PS01139 Bacterial microcompartiments proteins signature. 637910010526 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 637910010527 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 637910010528 putative hexamer interface [polypeptide binding]; other site 637910010529 putative hexagonal pore; other site 637910010530 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 2.2e-30 637910010531 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 637910010532 Propanediol utilisation protein PduL; Region: PduL; pfam06130 637910010533 Propanediol utilisation protein PduL; Region: PduL; pfam06130 637910010534 HMMPfam hit to PF06130, Propanediol utilization protein, score 4.2e-44 637910010535 HMMPfam hit to PF06130, Propanediol utilization protein, score 1.1e-33 637910010536 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 637910010537 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cl01889 637910010538 Hexamer/Pentamer interface [polypeptide binding]; other site 637910010539 central pore; other site 637910010540 HMMPfam hit to PF03319, Ethanolamine utilization protein EutN/carboxysome structural protein Ccml, score 6e-45 637910010541 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 637910010542 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 637910010543 HMMPfam hit to PF01923, Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase, score 2.6e-87 637910010544 HMMPfam hit to PF03928, Protein of unknown function DUF336, score 6e-55 637910010545 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 637910010546 putative catalytic cysteine [active] 637910010547 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 5.1e-09 637910010548 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 637910010549 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 637910010550 putative active site [active] 637910010551 metal binding site [ion binding]; metal-binding site 637910010552 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 4.1e-96 637910010553 PS00913 Iron-containing alcohol dehydrogenases signature 1. 637910010554 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 637910010555 SLBB domain; Region: SLBB; pfam10531 637910010556 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 637910010557 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 637910010558 HMMPfam hit to PF01512, Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit, score 1.6e-15 637910010559 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0097 637910010560 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910010561 Predicted helix-turn-helix motif with score 1230.000, SD 3.38 at aa 313-334, sequence NVCESVACPVGISPMRINRMLK 637910010562 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 637910010563 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 637910010564 putative hexamer interface [polypeptide binding]; other site 637910010565 putative hexagonal pore; other site 637910010566 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 637910010567 putative hexamer interface [polypeptide binding]; other site 637910010568 putative hexagonal pore; other site 637910010569 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 8e-30 637910010570 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 3.3e-32 637910010571 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 637910010572 putative hexamer interface [polypeptide binding]; other site 637910010573 putative hexagonal pore; other site 637910010574 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 1.3e-23 637910010575 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 637910010576 G1 box; other site 637910010577 GTP/Mg2+ binding site [chemical binding]; other site 637910010578 G2 box; other site 637910010579 G3 box; other site 637910010580 Switch II region; other site 637910010581 G4 box; other site 637910010582 G5 box; other site 637910010583 PS00017 ATP/GTP-binding site motif A (P-loop). 637910010584 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010585 propionate kinase; Reviewed; Region: PRK12397 637910010586 propionate/acetate kinase; Provisional; Region: PRK12379 637910010587 HMMPfam hit to PF00871, Acetate and butyrate kinase, score 1.4e-199 637910010588 PS01075 Acetate and butyrate kinases family signature 1. 637910010589 PS01076 Acetate and butyrate kinases family signature 2. 637910010590 Predicted helix-turn-helix motif with score 1092.000, SD 2.91 at aa 247-268, sequence SILPWLAQREGKTPQQLNQLLN 637910010591 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 637910010592 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 637910010593 HMMPfam hit to PF00288, GHMP kinase, score 4.7e-11 637910010594 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 5.9e-05 637910010595 hypothetical protein; Provisional; Region: PRK05423 637910010596 HMMPfam hit to PF04363, Protein of unknown function DUF496, score 3e-69 637910010597 pseudogene, truncated by frameshift mutation 637910010598 DNA gyrase inhibitor; Provisional; Region: PRK10016 637910010599 HMMPfam hit to PF06445, Bacterial transcription activator, effector binding, score 4.7e-33 637910010600 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 637910010601 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 637910010602 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 637910010603 HMMPfam hit to PF07943, Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal, score 5.6e-33 637910010604 HMMPfam hit to PF00768, Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, score 2.5e-145 637910010605 exonuclease I; Provisional; Region: sbcB; PRK11779 637910010606 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 637910010607 active site 637910010608 catalytic site [active] 637910010609 substrate binding site [chemical binding]; other site 637910010610 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 637910010611 HMMPfam hit to PF00929, Exonuclease, RNase T and DNA polymerase III, score 1.7e-37 637910010612 HMMPfam hit to PF08411, Exonuclease C-terminal, score 8e-171 637910010613 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 637910010614 CPxP motif; other site 637910010615 HMMPfam hit to PF01206, SirA-like, score 2.9e-37 637910010616 PS01148 Uncharacterized protein family UPF0033 signature. 637910010617 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 637910010618 Sulphur transport; Region: Sulf_transp; pfam04143 637910010619 HMMPfam hit to PF04143, Protein of unknown function DUF395, YeeE/YedE, score 1.5e-16 637910010620 9 transmembrane helices predicted for ROD21521 by TMHMM2.0 at aa 4-21, 42-64, 74-93, 106-123, 151-169, 198-217, 247-266, 287-309 and 319-338 637910010621 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010622 HMMPfam hit to PF04143, Protein of unknown function DUF395, YeeE/YedE, score 4.4e-12 637910010623 Transposase IS200 like; Region: Y1_Tnp; pfam01797 637910010624 HMMPfam hit to PF01797, Transposase IS200-like, score 6.3e-68 637910010625 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 637910010626 12 transmembrane helices predicted for ROD21541 by TMHMM2.0 at aa 20-38, 53-75, 96-118, 133-151, 160-182, 197-219, 240-262, 289-311, 342-364, 368-385, 398-417 and 422-439 637910010627 HMMPfam hit to PF00324, Amino acid permease-associated region, score 2.1e-19 637910010628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910010629 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 637910010630 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637910010631 dimerization interface [polypeptide binding]; other site 637910010632 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.7e-26 637910010633 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 6.3e-16 637910010634 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 637910010635 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 637910010636 putative NAD(P) binding site [chemical binding]; other site 637910010637 PS00017 ATP/GTP-binding site motif A (P-loop). 637910010638 HMMPfam hit to PF03446, 6-phosphogluconate dehydrogenase, NAD-binding, score 8.9e-05 637910010639 HMMPfam hit to PF08047, Histidine operon leader peptide, score 7e-06 637910010640 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 637910010641 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 637910010642 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 637910010643 HMMPfam hit to PF01634, ATP phosphoribosyltransferase, catalytic region, score 3.9e-83 637910010644 PS01316 ATP phosphoribosyltransferase signature. 637910010645 HMMPfam hit to PF08029, Histidine biosynthesis HisG, C-terminal, score 8.2e-39 637910010646 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 637910010647 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 637910010648 NAD binding site [chemical binding]; other site 637910010649 dimerization interface [polypeptide binding]; other site 637910010650 product binding site; other site 637910010651 substrate binding site [chemical binding]; other site 637910010652 zinc binding site [ion binding]; other site 637910010653 catalytic residues [active] 637910010654 HMMPfam hit to PF00815, Histidinol dehydrogenase, score 6.4e-275 637910010655 PS00611 Histidinol dehydrogenase signature. 637910010656 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 637910010657 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637910010658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910010659 homodimer interface [polypeptide binding]; other site 637910010660 catalytic residue [active] 637910010661 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 7.1e-94 637910010662 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 637910010663 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 637910010664 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910010665 active site 637910010666 motif I; other site 637910010667 motif II; other site 637910010668 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 637910010669 putative active site pocket [active] 637910010670 4-fold oligomerization interface [polypeptide binding]; other site 637910010671 metal binding residues [ion binding]; metal-binding site 637910010672 3-fold/trimer interface [polypeptide binding]; other site 637910010673 HMMPfam hit to PF08645, Polynucleotide kinase 3 phosphatase, central region, score 0.00036 637910010674 HMMPfam hit to PF00475, Imidazole glycerol-phosphate dehydratase, score 2.5e-107 637910010675 PS00954 Imidazoleglycerol-phosphate dehydratase signature 1. 637910010676 PS00955 Imidazoleglycerol-phosphate dehydratase signature 2. 637910010677 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 637910010678 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 637910010679 putative active site [active] 637910010680 oxyanion strand; other site 637910010681 catalytic triad [active] 637910010682 PS00136 Serine proteases, subtilase family, aspartic acid active site. 637910010683 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 1.2e-43 637910010684 PS00442 Glutamine amidotransferases class-I active site. 637910010685 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 637910010686 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 637910010687 catalytic residues [active] 637910010688 HMMPfam hit to PF00977, Histidine biosynthesis, score 4.8e-109 637910010689 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 637910010690 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 637910010691 substrate binding site [chemical binding]; other site 637910010692 glutamase interaction surface [polypeptide binding]; other site 637910010693 HMMPfam hit to PF00977, Histidine biosynthesis, score 1.9e-117 637910010694 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 637910010695 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 637910010696 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 637910010697 metal binding site [ion binding]; metal-binding site 637910010698 HMMPfam hit to PF01502, Phosphoribosyl-AMP cyclohydrolase, score 1.3e-47 637910010699 HMMPfam hit to PF01503, Phosphoribosyl-ATP pyrophosphohydrolase, score 8.9e-48 637910010700 chain length determinant protein WzzB; Provisional; Region: PRK15471 637910010701 Chain length determinant protein; Region: Wzz; cl15801 637910010702 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 637910010703 2 transmembrane helices predicted for ROD21651 by TMHMM2.0 at aa 32-51 and 296-315 637910010704 HMMPfam hit to PF02706, Lipopolysaccharide biosynthesis, score 8.3e-23 637910010705 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 637910010706 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 637910010707 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 637910010708 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 637910010709 HMMPfam hit to PF03720, UDP-glucose/GDP-mannose dehydrogenase, C-terminal, score 1.9e-05 637910010710 HMMPfam hit to PF00984, UDP-glucose/GDP-mannose dehydrogenase, dimerisation, score 1.6e-36 637910010711 HMMPfam hit to PF03721, UDP-glucose/GDP-mannose dehydrogenase, N-terminal, score 4.8e-43 637910010712 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 637910010713 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 637910010714 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 637910010715 HMMPfam hit to PF00393, 6-phosphogluconate dehydrogenase, C-terminal, score 1.8e-257 637910010716 PS00461 6-phosphogluconate dehydrogenase signature. 637910010717 HMMPfam hit to PF03446, 6-phosphogluconate dehydrogenase, NAD-binding, score 1.9e-93 637910010718 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637910010719 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 637910010720 putative ADP-binding pocket [chemical binding]; other site 637910010721 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 1e-41 637910010722 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910010723 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 637910010724 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637910010725 active site 637910010726 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 2.8e-37 637910010727 11 transmembrane helices predicted for ROD21701 by TMHMM2.0 at aa 2-21, 31-53, 65-87, 92-109, 116-138, 158-180, 189-211, 235-252, 265-287, 292-311 and 318-337 637910010728 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010729 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 637910010730 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 637910010731 10 transmembrane helices predicted for ROD21721 by TMHMM2.0 at aa 5-27, 37-59, 80-102, 107-129, 164-186, 212-234, 280-299, 319-341, 348-367 and 377-399 637910010732 HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 1.7e-56 637910010733 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 637910010734 putative ligand binding site [chemical binding]; other site 637910010735 putative catalytic site [active] 637910010736 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 637910010737 HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose 3,5-epimerase related, score 2.8e-122 637910010738 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 637910010739 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 637910010740 substrate binding site; other site 637910010741 tetramer interface; other site 637910010742 HMMPfam hit to PF00483, Nucleotidyl transferase, score 1.6e-115 637910010743 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 637910010744 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 637910010745 NADP binding site [chemical binding]; other site 637910010746 active site 637910010747 putative substrate binding site [chemical binding]; other site 637910010748 HMMPfam hit to PF04321, dTDP-4-dehydrorhamnose reductase, score 4.2e-158 637910010749 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 637910010750 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 637910010751 NAD binding site [chemical binding]; other site 637910010752 substrate binding site [chemical binding]; other site 637910010753 homodimer interface [polypeptide binding]; other site 637910010754 active site 637910010755 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 1.4e-94 637910010756 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 637910010757 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 637910010758 active site 637910010759 tetramer interface; other site 637910010760 HMMPfam hit to PF00483, Nucleotidyl transferase, score 4.7e-11 637910010761 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 637910010762 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 637910010763 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 637910010764 putative ADP-binding pocket [chemical binding]; other site 637910010765 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 1.7e-43 637910010766 colanic acid biosynthesis protein; Provisional; Region: PRK10017 637910010767 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 637910010768 HMMPfam hit to PF04230, Polysaccharide pyruvyl transferase, score 1.1e-153 637910010769 colanic acid exporter; Provisional; Region: PRK10459 637910010770 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 637910010771 10 transmembrane helices predicted for ROD21821 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 165-187, 286-308, 323-340, 361-383, 387-409, 416-438 and 453-472 637910010772 HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 3.5e-75 637910010773 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 637910010774 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 637910010775 HMMPfam hit to PF02397, Bacterial sugar transferase, score 6.5e-42 637910010776 5 transmembrane helices predicted for ROD21831 by TMHMM2.0 at aa 12-34, 44-66, 79-101, 111-130 and 279-300 637910010777 phosphomannomutase CpsG; Provisional; Region: PRK15414 637910010778 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 637910010779 active site 637910010780 substrate binding site [chemical binding]; other site 637910010781 metal binding site [ion binding]; metal-binding site 637910010782 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase C-terminal, score 8.6e-31 637910010783 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III, score 6.5e-56 637910010784 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II, score 3.5e-58 637910010785 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I, score 6.8e-50 637910010786 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 637910010787 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 637910010788 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 637910010789 Substrate binding site; other site 637910010790 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 637910010791 HMMPfam hit to PF01050, Mannose-6-phosphate isomerase, type II, C-terminal, score 2.2e-132 637910010792 HMMPfam hit to PF00483, Nucleotidyl transferase, score 3.6e-143 637910010793 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 637910010794 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 637910010795 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 1.4e-20 637910010796 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 637910010797 dimer interface [polypeptide binding]; other site 637910010798 active site 637910010799 GDP-Mannose binding site [chemical binding]; other site 637910010800 modified nudix motif 637910010801 metal binding site [ion binding]; metal-binding site 637910010802 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 5.9e-25 637910010803 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 637910010804 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 637910010805 NADP binding site [chemical binding]; other site 637910010806 active site 637910010807 putative substrate binding site [chemical binding]; other site 637910010808 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 2.3e-90 637910010809 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 637910010810 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 637910010811 NADP-binding site; other site 637910010812 homotetramer interface [polypeptide binding]; other site 637910010813 substrate binding site [chemical binding]; other site 637910010814 homodimer interface [polypeptide binding]; other site 637910010815 active site 637910010816 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 1.1e-111 637910010817 PS00061 Short-chain dehydrogenases/reductases family signature. 637910010818 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 637910010819 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 637910010820 putative trimer interface [polypeptide binding]; other site 637910010821 putative active site [active] 637910010822 putative substrate binding site [chemical binding]; other site 637910010823 putative CoA binding site [chemical binding]; other site 637910010824 PS00101 Hexapeptide-repeat containing-transferases signature. 637910010825 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.12 637910010826 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 1.1e+02 637910010827 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.45 637910010828 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 637910010829 putative glycosyl transferase; Provisional; Region: PRK10063 637910010830 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 637910010831 metal-binding site 637910010832 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 4.7e-21 637910010833 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 637910010834 11 transmembrane helices predicted for ROD21921 by TMHMM2.0 at aa 7-25, 30-47, 54-76, 81-103, 115-137, 172-191, 203-225, 245-264, 277-299, 326-348 and 368-390 637910010835 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 637910010836 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 637910010837 putative acyl transferase; Provisional; Region: PRK10191 637910010838 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 637910010839 trimer interface [polypeptide binding]; other site 637910010840 active site 637910010841 substrate binding site [chemical binding]; other site 637910010842 CoA binding site [chemical binding]; other site 637910010843 PS00101 Hexapeptide-repeat containing-transferases signature. 637910010844 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.053 637910010845 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 9.9 637910010846 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 93 637910010847 putative glycosyl transferase; Provisional; Region: PRK10018 637910010848 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 637910010849 active site 637910010850 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 7e-32 637910010851 tyrosine kinase; Provisional; Region: PRK11519 637910010852 Chain length determinant protein; Region: Wzz; pfam02706 637910010853 Chain length determinant protein; Region: Wzz; cl15801 637910010854 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 637910010855 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 637910010856 3 transmembrane helices predicted for ROD21961 by TMHMM2.0 at aa 32-54, 427-449 and 528-550 637910010857 HMMPfam hit to PF02706, Lipopolysaccharide biosynthesis, score 2.1e-87 637910010858 Low molecular weight phosphatase family; Region: LMWPc; cd00115 637910010859 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 637910010860 active site 637910010861 HMMPfam hit to PF01451, Protein-tyrosine phosphatase, low molecular weight, score 1.2e-64 637910010862 polysaccharide export protein Wza; Provisional; Region: PRK15078 637910010863 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 637910010864 SLBB domain; Region: SLBB; pfam10531 637910010865 HMMPfam hit to PF02563, Polysaccharide export protein, score 1.2e-66 637910010866 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010867 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 637910010868 FOG: CBS domain [General function prediction only]; Region: COG0517 637910010869 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637910010870 Transporter associated domain; Region: CorC_HlyC; smart01091 637910010871 HMMPfam hit to PF03741, Integral membrane protein TerC, score 2.1e-37 637910010872 7 transmembrane helices predicted for ROD21991 by TMHMM2.0 at aa 13-35, 48-70, 80-99, 126-148, 153-172, 185-207 and 212-234 637910010873 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 1.2e-22 637910010874 HMMPfam hit to PF03471, Transporter-associated region, score 3.7e-23 637910010875 putative assembly protein; Provisional; Region: PRK10833 637910010876 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 637910010877 HMMPfam hit to PF05170, AsmA, score 5.4e-139 637910010878 1 transmembrane helix predicted for ROD22001 by TMHMM2.0 at aa 7-26 637910010879 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 637910010880 trimer interface [polypeptide binding]; other site 637910010881 active site 637910010882 HMMPfam hit to PF00692, DeoxyUTP pyrophosphatase, score 0.00098 637910010883 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 637910010884 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 637910010885 ATP-binding site [chemical binding]; other site 637910010886 Sugar specificity; other site 637910010887 Pyrimidine base specificity; other site 637910010888 HMMPfam hit to PF00485, Phosphoribulokinase/uridine kinase, score 7e-52 637910010889 PS00017 ATP/GTP-binding site motif A (P-loop). 637910010890 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 637910010891 PAS domain S-box; Region: sensory_box; TIGR00229 637910010892 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637910010893 putative active site [active] 637910010894 heme pocket [chemical binding]; other site 637910010895 PAS domain S-box; Region: sensory_box; TIGR00229 637910010896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637910010897 putative active site [active] 637910010898 heme pocket [chemical binding]; other site 637910010899 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637910010900 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637910010901 metal binding site [ion binding]; metal-binding site 637910010902 active site 637910010903 I-site; other site 637910010904 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 637910010905 11 transmembrane helices predicted for ROD22031 by TMHMM2.0 at aa 7-29, 39-58, 65-84, 89-111, 124-146, 156-177, 190-207, 211-228, 235-252, 267-289 and 310-327 637910010906 HMMPfam hit to PF05231, MASE1, score 5.8e-39 637910010907 HMMPfam hit to PF00989, PAS fold, score 4.2e-10 637910010908 HMMPfam hit to PF08448, PAS fold-4, score 1.9e-12 637910010909 HMMPfam hit to PF00990, GGDEF, score 3.8e-61 637910010910 HMMPfam hit to PF00563, EAL, score 6.7e-06 637910010911 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 637910010912 AlkA N-terminal domain; Region: AlkA_N; pfam06029 637910010913 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 637910010914 minor groove reading motif; other site 637910010915 helix-hairpin-helix signature motif; other site 637910010916 substrate binding pocket [chemical binding]; other site 637910010917 active site 637910010918 HMMPfam hit to PF00730, HhH-GPD, score 1.9e-17 637910010919 PS00516 Alkylbase DNA glycosidases alkA family signature. 637910010920 HMMPfam hit to PF06029, AlkA, N-terminal, score 3e-47 637910010921 putative chaperone; Provisional; Region: PRK11678 637910010922 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 637910010923 nucleotide binding site [chemical binding]; other site 637910010924 putative NEF/HSP70 interaction site [polypeptide binding]; other site 637910010925 SBD interface [polypeptide binding]; other site 637910010926 HMMPfam hit to PF00012, Heat shock protein 70, score 0.00015 637910010927 HMMPfam hit to PF00012, Heat shock protein 70, score 0.00018 637910010928 PS00329 Heat shock hsp70 proteins family signature 2. 637910010929 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 637910010930 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637910010931 HlyD family secretion protein; Region: HlyD_3; pfam13437 637910010932 1 transmembrane helix predicted for ROD22061 by TMHMM2.0 at aa 7-26 637910010933 HMMPfam hit to PF00529, Secretion protein HlyD, score 1.6e-24 637910010934 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 637910010935 Protein export membrane protein; Region: SecD_SecF; cl14618 637910010936 HMMPfam hit to PF00873, Acriflavin resistance protein, score 0 637910010937 11 transmembrane helices predicted for ROD22071 by TMHMM2.0 at aa 15-37, 345-362, 367-389, 396-418, 438-460, 472-494, 535-557, 867-889, 909-931, 968-990 and 1000-1022 637910010938 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 637910010939 HMMPfam hit to PF00873, Acriflavin resistance protein, score 0 637910010940 10 transmembrane helices predicted for ROD22081 by TMHMM2.0 at aa 7-29, 336-353, 360-379, 389-411, 431-453, 468-490, 853-875, 895-917, 948-970 and 985-1007 637910010941 putative transporter; Provisional; Region: PRK10504 637910010942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910010943 putative substrate translocation pore; other site 637910010944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910010945 14 transmembrane helices predicted for ROD22091 by TMHMM2.0 at aa 12-34, 47-69, 76-98, 102-124, 136-158, 163-185, 197-214, 220-242, 263-285, 290-312, 324-346, 350-372, 393-415 and 430-452 637910010946 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 8e-54 637910010947 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910010948 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 637910010949 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637910010950 dimerization interface [polypeptide binding]; other site 637910010951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637910010952 dimer interface [polypeptide binding]; other site 637910010953 phosphorylation site [posttranslational modification] 637910010954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910010955 ATP binding site [chemical binding]; other site 637910010956 Mg2+ binding site [ion binding]; other site 637910010957 G-X-G motif; other site 637910010958 2 transmembrane helices predicted for ROD22101 by TMHMM2.0 at aa 13-35 and 167-186 637910010959 PS00213 Lipocalin signature. 637910010960 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 1.6e-17 637910010961 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 2.6e-17 637910010962 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.9e-38 637910010963 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 637910010964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910010965 active site 637910010966 phosphorylation site [posttranslational modification] 637910010967 intermolecular recognition site; other site 637910010968 dimerization interface [polypeptide binding]; other site 637910010969 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637910010970 DNA binding site [nucleotide binding] 637910010971 HMMPfam hit to PF00072, Response regulator receiver, score 1.7e-32 637910010972 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1.8e-21 637910010973 PS00294 Prenyl group binding site (CAAX box). 637910010974 Tetratricopeptide repeat; Region: TPR_12; pfam13424 637910010975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637910010976 binding surface 637910010977 TPR motif; other site 637910010978 putative protease; Provisional; Region: PRK15452 637910010979 Peptidase family U32; Region: Peptidase_U32; pfam01136 637910010980 HMMPfam hit to PF01136, Peptidase U32, score 3.7e-149 637910010981 PS01276 Peptidase family U32 signature. 637910010982 lipid kinase; Reviewed; Region: PRK13054 637910010983 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 637910010984 HMMPfam hit to PF00781, Diacylglycerol kinase, catalytic region, score 1.3e-37 637910010985 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 637910010986 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637910010987 Walker A/P-loop; other site 637910010988 ATP binding site [chemical binding]; other site 637910010989 Q-loop/lid; other site 637910010990 ABC transporter signature motif; other site 637910010991 Walker B; other site 637910010992 D-loop; other site 637910010993 H-loop/switch region; other site 637910010994 HMMPfam hit to PF00005, ABC transporter related, score 2e-66 637910010995 PS00211 ABC transporters family signature. 637910010996 PS00017 ATP/GTP-binding site motif A (P-loop). 637910010997 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 637910010998 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637910010999 Walker A/P-loop; other site 637910011000 ATP binding site [chemical binding]; other site 637910011001 Q-loop/lid; other site 637910011002 ABC transporter signature motif; other site 637910011003 Walker B; other site 637910011004 D-loop; other site 637910011005 H-loop/switch region; other site 637910011006 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 637910011007 HMMPfam hit to PF00005, ABC transporter related, score 3.3e-44 637910011008 PS00017 ATP/GTP-binding site motif A (P-loop). 637910011009 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 637910011010 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 637910011011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910011012 dimer interface [polypeptide binding]; other site 637910011013 conserved gate region; other site 637910011014 ABC-ATPase subunit interface; other site 637910011015 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3.8e-42 637910011016 5 transmembrane helices predicted for ROD22181 by TMHMM2.0 at aa 37-59, 102-124, 139-161, 228-245 and 265-287 637910011017 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 637910011018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910011019 dimer interface [polypeptide binding]; other site 637910011020 conserved gate region; other site 637910011021 putative PBP binding loops; other site 637910011022 ABC-ATPase subunit interface; other site 637910011023 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 5.8e-43 637910011024 6 transmembrane helices predicted for ROD22191 by TMHMM2.0 at aa 20-42, 109-131, 144-166, 204-226, 267-289 and 309-331 637910011025 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 637910011026 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 637910011027 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 1e-65 637910011028 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 637910011029 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 637910011030 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 637910011031 putative active site pocket [active] 637910011032 metal binding site [ion binding]; metal-binding site 637910011033 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 1.1e-35 637910011034 HMMPfam hit to PF02746, Mandelate racemase/muconate lactonizing enzyme, N-terminal, score 5.3e-05 637910011035 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 637910011036 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 637910011037 putative active site; other site 637910011038 catalytic residue [active] 637910011039 HMMPfam hit to PF01791, Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase, score 1.3e-87 637910011040 nucleoside transporter; Region: 2A0110; TIGR00889 637910011041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910011042 putative substrate translocation pore; other site 637910011043 HMMPfam hit to PF03825, Nucleoside:H+ symporter, score 4.9e-274 637910011044 12 transmembrane helices predicted for ROD22231 by TMHMM2.0 at aa 7-29, 39-61, 70-87, 97-119, 132-154, 159-181, 211-233, 243-265, 274-291, 301-323, 336-358 and 378-400 637910011045 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 637910011046 HMMPfam hit to PF03747, ADP-ribosylation/Crystallin J1, score 9.4e-102 637910011047 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 637910011048 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 637910011049 substrate binding site [chemical binding]; other site 637910011050 ATP binding site [chemical binding]; other site 637910011051 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 1.7e-51 637910011052 PS00583 pfkB family of carbohydrate kinases signature 1. 637910011053 PS00584 pfkB family of carbohydrate kinases signature 2. 637910011054 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637910011055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910011056 DNA-binding site [nucleotide binding]; DNA binding site 637910011057 UTRA domain; Region: UTRA; pfam07702 637910011058 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 1.2e-44 637910011059 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 1e-17 637910011060 Predicted helix-turn-helix motif with score 1126.000, SD 3.02 at aa 48-69, sequence PGERDLSQLTGVSRITVRKAMQ 637910011061 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 637910011062 dimer interface [polypeptide binding]; other site 637910011063 substrate binding site [chemical binding]; other site 637910011064 ATP binding site [chemical binding]; other site 637910011065 HMMPfam hit to PF08543, Phosphomethylpyrimidine kinase type-1, score 1.1e-138 637910011066 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 637910011067 substrate binding site [chemical binding]; other site 637910011068 multimerization interface [polypeptide binding]; other site 637910011069 ATP binding site [chemical binding]; other site 637910011070 HMMPfam hit to PF02110, Hydroxyethylthiazole kinase, score 1.8e-133 637910011071 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011072 Predicted integral membrane protein [Function unknown]; Region: COG5455 637910011073 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 637910011074 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 637910011075 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 0.012 637910011076 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 637910011077 PapC N-terminal domain; Region: PapC_N; pfam13954 637910011078 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637910011079 PapC C-terminal domain; Region: PapC_C; pfam13953 637910011080 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 2e-275 637910011081 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 637910011082 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637910011083 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 1.2e-06 637910011084 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 2.5e-60 637910011085 PS00635 Gram-negative pili assembly chaperone signature. 637910011086 1 transmembrane helix predicted for ROD22331 by TMHMM2.0 at aa 7-29 637910011087 fimbrial chaperone protein; Provisional; Region: PRK15220 637910011088 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 0.0008 637910011089 PS00237 G-protein coupled receptors signature. 637910011090 1 transmembrane helix predicted for ROD22341 by TMHMM2.0 at aa 5-22 637910011091 antiporter inner membrane protein; Provisional; Region: PRK11670 637910011092 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 637910011093 Walker A motif; other site 637910011094 PS01215 Mrp family signature. 637910011095 PS00017 ATP/GTP-binding site motif A (P-loop). 637910011096 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 637910011097 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 637910011098 active site 637910011099 HIGH motif; other site 637910011100 KMSKS motif; other site 637910011101 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 637910011102 tRNA binding surface [nucleotide binding]; other site 637910011103 anticodon binding site; other site 637910011104 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 637910011105 dimer interface [polypeptide binding]; other site 637910011106 putative tRNA-binding site [nucleotide binding]; other site 637910011107 HMMPfam hit to PF09334, Aminoacyl-tRNA synthetase, class I (M), score 9.4e-234 637910011108 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 637910011109 HMMPfam hit to PF01588, tRNA-binding region, score 6.8e-42 637910011110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 637910011111 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 637910011112 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 637910011113 HMMPfam hit to PF07308, Protein of unknown function DUF1456, score 8.6e-33 637910011114 HMMPfam hit to PF07308, Protein of unknown function DUF1456, score 3.6e-28 637910011115 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 637910011116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910011117 active site 637910011118 phosphorylation site [posttranslational modification] 637910011119 intermolecular recognition site; other site 637910011120 dimerization interface [polypeptide binding]; other site 637910011121 LytTr DNA-binding domain; Region: LytTR; pfam04397 637910011122 HMMPfam hit to PF04397, LytTr DNA-binding region, score 5.1e-28 637910011123 HMMPfam hit to PF00072, Response regulator receiver, score 4e-42 637910011124 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 637910011125 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 637910011126 GAF domain; Region: GAF; pfam01590 637910011127 Histidine kinase; Region: His_kinase; pfam06580 637910011128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910011129 ATP binding site [chemical binding]; other site 637910011130 Mg2+ binding site [ion binding]; other site 637910011131 G-X-G motif; other site 637910011132 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 8.1e-13 637910011133 HMMPfam hit to PF06580, Histidine kinase internal region, score 2.6e-42 637910011134 HMMPfam hit to PF01590, GAF, score 0.00018 637910011135 6 transmembrane helices predicted for ROD22391 by TMHMM2.0 at aa 4-23, 44-64, 74-96, 103-125, 140-162 and 169-191 637910011136 HMMPfam hit to PF07694, 5TM Receptors of the LytS-YhcK type, transmembrane region, score 9.7e-41 637910011137 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011138 transcriptional regulator MirA; Provisional; Region: PRK15043 637910011139 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 637910011140 DNA binding residues [nucleotide binding] 637910011141 Predicted helix-turn-helix motif with score 1630.000, SD 4.74 at aa 4-25, sequence YTIGEVALLCDINPVTLRAWQR 637910011142 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 4.9e-12 637910011143 PS00552 Bacterial regulatory proteins, merR family signature. 637910011144 hypothetical protein; Provisional; Region: PRK13681 637910011145 1 transmembrane helix predicted for ROD22402 by TMHMM2.0 at aa 7-29 637910011146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910011147 dimer interface [polypeptide binding]; other site 637910011148 conserved gate region; other site 637910011149 putative PBP binding loops; other site 637910011150 ABC-ATPase subunit interface; other site 637910011151 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 8.3e-30 637910011152 6 transmembrane helices predicted for ROD22411 by TMHMM2.0 at aa 7-29, 54-76, 89-111, 121-143, 164-186 and 201-223 637910011153 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 637910011154 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 637910011155 Walker A/P-loop; other site 637910011156 ATP binding site [chemical binding]; other site 637910011157 Q-loop/lid; other site 637910011158 ABC transporter signature motif; other site 637910011159 Walker B; other site 637910011160 D-loop; other site 637910011161 H-loop/switch region; other site 637910011162 CBS domain; Region: CBS; pfam00571 637910011163 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 6.2e-05 637910011164 HMMPfam hit to PF00005, ABC transporter related, score 4.6e-58 637910011165 PS00211 ABC transporters family signature. 637910011166 PS00017 ATP/GTP-binding site motif A (P-loop). 637910011167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910011168 dimer interface [polypeptide binding]; other site 637910011169 conserved gate region; other site 637910011170 ABC-ATPase subunit interface; other site 637910011171 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 6.1e-24 637910011172 10 transmembrane helices predicted for ROD22431 by TMHMM2.0 at aa 9-26, 41-63, 70-89, 104-123, 135-157, 183-205, 212-234, 249-271, 324-346 and 356-378 637910011173 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910011174 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011175 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011176 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 637910011177 HMMPfam hit to PF04069, Substrate-binding region of ABC-type glycine betaine transport system, score 4.4e-79 637910011178 polyol permease family; Region: 2A0118; TIGR00897 637910011179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910011180 putative substrate translocation pore; other site 637910011181 12 transmembrane helices predicted for ROD22451 by TMHMM2.0 at aa 21-43, 58-80, 87-106, 116-138, 145-167, 177-199, 232-254, 264-286, 295-317, 327-349, 362-384 and 388-407 637910011182 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 9.7e-19 637910011183 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 637910011184 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 637910011185 12 transmembrane helices predicted for ROD22461 by TMHMM2.0 at aa 21-43, 53-75, 88-105, 109-131, 151-173, 183-205, 255-277, 287-306, 313-335, 339-361, 382-404 and 424-446 637910011186 PS00340 Growth factor and cytokines receptors family signature 2. 637910011187 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 2.6e-10 637910011188 pseudogene, truncated by premature stop codon 637910011189 HMMPfam hit to PF00295, Glycoside hydrolase, family 28, score 1.4e-05 637910011190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910011191 AAA domain; Region: AAA_21; pfam13304 637910011192 Walker A/P-loop; other site 637910011193 ATP binding site [chemical binding]; other site 637910011194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910011195 Q-loop/lid; other site 637910011196 ABC transporter signature motif; other site 637910011197 Walker B; other site 637910011198 D-loop; other site 637910011199 H-loop/switch region; other site 637910011200 PS00017 ATP/GTP-binding site motif A (P-loop). 637910011201 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 637910011202 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 637910011203 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 637910011204 HMMPfam hit to PF01915, Glycoside hydrolase, family 3, C-terminal, score 1.3e-102 637910011205 HMMPfam hit to PF00933, Glycoside hydrolase, family 3, N-terminal, score 1.3e-103 637910011206 PS00775 Glycosyl hydrolases family 3 active site. 637910011207 D-lactate dehydrogenase; Provisional; Region: PRK11183 637910011208 FAD binding domain; Region: FAD_binding_4; pfam01565 637910011209 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 637910011210 HMMPfam hit to PF01565, FAD linked oxidase, N-terminal, score 7e-09 637910011211 HMMPfam hit to PF09330, D-lactate dehydrogenase, membrane binding, C-terminal, score 1.2e-231 637910011212 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 637910011213 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 637910011214 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637910011215 Coenzyme A binding pocket [chemical binding]; other site 637910011216 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 3.9e-13 637910011217 2 transmembrane helices predicted for ROD22541 by TMHMM2.0 at aa 15-34 and 105-127 637910011218 PAAR motif; Region: PAAR_motif; pfam05488 637910011219 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011220 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 637910011221 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 637910011222 HMMPfam hit to PF00768, Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, score 6.7e-124 637910011223 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 637910011224 HMMPfam hit to PF06930, Protein of unknown function DUF1282, score 1.3e-134 637910011225 5 transmembrane helices predicted for ROD22581 by TMHMM2.0 at aa 33-55, 65-87, 108-130, 135-157 and 170-192 637910011226 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 637910011227 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 637910011228 4 transmembrane helices predicted for ROD22591 by TMHMM2.0 at aa 13-35, 48-70, 100-122 and 170-187 637910011229 HMMPfam hit to PF09335, SNARE associated Golgi protein, score 7.3e-06 637910011230 oxidoreductase; Provisional; Region: PRK12743 637910011231 classical (c) SDRs; Region: SDR_c; cd05233 637910011232 NAD(P) binding site [chemical binding]; other site 637910011233 active site 637910011234 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 1.3e-24 637910011235 PS00061 Short-chain dehydrogenases/reductases family signature. 637910011236 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 637910011237 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.5e-36 637910011238 HMMPfam hit to PF02321, Outer membrane efflux protein, score 5.2e-16 637910011239 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011240 pseudogene, truncated by premature stop codon 637910011241 HMMPfam hit to PF01207, Dihydrouridine synthase, DuS, score 2.3e-132 637910011242 salicylate hydroxylase; Provisional; Region: PRK08163 637910011243 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 637910011244 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 3.9e-09 637910011245 1 transmembrane helix predicted for ROD22631 by TMHMM2.0 at aa 7-24 637910011246 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 637910011247 maleylacetoacetate isomerase; Region: maiA; TIGR01262 637910011248 C-terminal domain interface [polypeptide binding]; other site 637910011249 GSH binding site (G-site) [chemical binding]; other site 637910011250 putative dimer interface [polypeptide binding]; other site 637910011251 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 637910011252 dimer interface [polypeptide binding]; other site 637910011253 N-terminal domain interface [polypeptide binding]; other site 637910011254 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 637910011255 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 5.9e-07 637910011256 Predicted helix-turn-helix motif with score 1208.000, SD 3.30 at aa 111-132, sequence RVLRYLSEELKVSEGEVKRWYA 637910011257 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 7.6e-12 637910011258 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 637910011259 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 637910011260 HMMPfam hit to PF01557, Fumarylacetoacetase, C-terminal-like, score 1.2e-57 637910011261 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 637910011262 Cupin domain; Region: Cupin_2; pfam07883 637910011263 Cupin domain; Region: Cupin_2; pfam07883 637910011264 HMMPfam hit to PF07883, Cupin 2, conserved barrel, score 0.00094 637910011265 HMMPfam hit to PF07883, Cupin 2, conserved barrel, score 2.4e-22 637910011266 benzoate transport; Region: 2A0115; TIGR00895 637910011267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910011268 putative substrate translocation pore; other site 637910011269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910011270 putative substrate translocation pore; other site 637910011271 12 transmembrane helices predicted for ROD22671 by TMHMM2.0 at aa 23-45, 55-77, 89-108, 113-135, 148-170, 175-197, 253-275, 290-312, 319-338, 342-364, 385-407 and 412-434 637910011272 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 6.2e-57 637910011273 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 637910011274 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910011275 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637910011276 dimerization interface [polypeptide binding]; other site 637910011277 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 6.7e-17 637910011278 Predicted helix-turn-helix motif with score 2318.000, SD 7.08 at aa 23-44, sequence GNLTQVARMMNITQPALSKWLS 637910011279 PS00044 Bacterial regulatory proteins, lysR family signature. 637910011280 HMMPfam hit to PF03466, LysR, substrate-binding, score 8.8e-36 637910011281 hypothetical protein; Provisional; Region: PRK01821 637910011282 4 transmembrane helices predicted for ROD22691 by TMHMM2.0 at aa 7-29, 34-56, 63-85 and 95-117 637910011283 HMMPfam hit to PF03788, LrgA, score 3.9e-53 637910011284 hypothetical protein; Provisional; Region: PRK10711 637910011285 6 transmembrane helices predicted for ROD22701 by TMHMM2.0 at aa 4-23, 30-52, 90-112, 119-141, 145-167 and 205-227 637910011286 HMMPfam hit to PF04172, LrgB-like protein, score 4.5e-123 637910011287 cytidine deaminase; Provisional; Region: PRK09027 637910011288 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 637910011289 active site 637910011290 catalytic motif [active] 637910011291 Zn binding site [ion binding]; other site 637910011292 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 637910011293 active site 637910011294 catalytic motif [active] 637910011295 Zn binding site [ion binding]; other site 637910011296 HMMPfam hit to PF00383, CMP/dCMP deaminase, zinc-binding, score 1.5e-22 637910011297 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011298 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 637910011299 HMMPfam hit to PF08211, Cytidine and deoxycytidylate deaminase, zinc-binding region, score 2.5e-76 637910011300 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 637910011301 putative active site [active] 637910011302 1 transmembrane helix predicted for ROD22721 by TMHMM2.0 at aa 5-27 637910011303 HMMPfam hit to PF02698, Protein of unknown function DUF218, score 2.3e-38 637910011304 2 transmembrane helices predicted for ROD22731 by TMHMM2.0 at aa 5-24 and 55-77 637910011305 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 637910011306 2 transmembrane helices predicted for ROD22741 by TMHMM2.0 at aa 5-24 and 56-78 637910011307 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637910011308 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637910011309 TM-ABC transporter signature motif; other site 637910011310 9 transmembrane helices predicted for ROD22751 by TMHMM2.0 at aa 20-42, 49-68, 100-122, 127-149, 179-201, 222-244, 259-281, 286-308 and 312-330 637910011311 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 3.5e-65 637910011312 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637910011313 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 637910011314 Walker A/P-loop; other site 637910011315 ATP binding site [chemical binding]; other site 637910011316 Q-loop/lid; other site 637910011317 ABC transporter signature motif; other site 637910011318 Walker B; other site 637910011319 D-loop; other site 637910011320 H-loop/switch region; other site 637910011321 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637910011322 HMMPfam hit to PF00005, ABC transporter related, score 1.6e-21 637910011323 PS00211 ABC transporters family signature. 637910011324 HMMPfam hit to PF00005, ABC transporter related, score 4.5e-41 637910011325 PS00017 ATP/GTP-binding site motif A (P-loop). 637910011326 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 637910011327 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 637910011328 ligand binding site [chemical binding]; other site 637910011329 calcium binding site [ion binding]; other site 637910011330 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 0.00058 637910011331 1 transmembrane helix predicted for ROD22771 by TMHMM2.0 at aa 5-24 637910011332 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 637910011333 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910011334 DNA binding site [nucleotide binding] 637910011335 domain linker motif; other site 637910011336 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 637910011337 dimerization interface (closed form) [polypeptide binding]; other site 637910011338 ligand binding site [chemical binding]; other site 637910011339 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 6.6e-14 637910011340 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 7.9e-13 637910011341 Predicted helix-turn-helix motif with score 2365.000, SD 7.24 at aa 2-23, sequence ITIRDVARQAGVSVATVSRVLN 637910011342 PS00356 Bacterial regulatory proteins, lacI family signature. 637910011343 Predicted membrane protein [Function unknown]; Region: COG2311 637910011344 hypothetical protein; Provisional; Region: PRK10835 637910011345 HMMPfam hit to PF04235, Protein of unknown function DUF418, score 1.7e-53 637910011346 9 transmembrane helices predicted for ROD22801 by TMHMM2.0 at aa 12-34, 49-71, 83-102, 107-123, 130-152, 199-221, 234-256, 308-330 and 337-359 637910011347 HMMPfam hit to PF04171, Protein of unknown function DUF405, score 1e-60 637910011348 GTP cyclohydrolase I; Provisional; Region: PLN03044 637910011349 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 637910011350 active site 637910011351 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 4.4e-56 637910011352 PS00860 GTP cyclohydrolase I signature 2. 637910011353 PS00859 GTP cyclohydrolase I signature 1. 637910011354 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 637910011355 S-formylglutathione hydrolase; Region: PLN02442 637910011356 HMMPfam hit to PF00756, esterase, score 2e-112 637910011357 putative outer membrane receptor; Provisional; Region: PRK13513 637910011358 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637910011359 N-terminal plug; other site 637910011360 ligand-binding site [chemical binding]; other site 637910011361 PS00430 TonB-dependent receptor proteins signature 1. 637910011362 HMMPfam hit to PF07715, TonB-dependent receptor, plug, score 6.2e-31 637910011363 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 1.5e-29 637910011364 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 637910011365 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910011366 HMMPfam hit to PF01609, Transposase, IS4-like, score 3.6e-29 637910011367 lysine transporter; Provisional; Region: PRK10836 637910011368 HMMPfam hit to PF00324, Amino acid permease-associated region, score 1.5e-201 637910011369 12 transmembrane helices predicted for ROD22851 by TMHMM2.0 at aa 21-43, 53-75, 103-125, 130-152, 159-181, 196-218, 245-267, 287-309, 343-365, 370-392, 413-435 and 445-467 637910011370 PS00218 Amino acid permeases signature. 637910011371 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 637910011372 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910011373 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 637910011374 putative dimerization interface [polypeptide binding]; other site 637910011375 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.3e-52 637910011376 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.1e-17 637910011377 PS00044 Bacterial regulatory proteins, lysR family signature. 637910011378 Predicted helix-turn-helix motif with score 1086.000, SD 2.89 at aa 18-39, sequence GSTTQASVMLALSQSAVSAALT 637910011379 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 637910011380 10 transmembrane helices predicted for ROD22871 by TMHMM2.0 at aa 13-32, 36-58, 100-122, 132-151, 164-186, 196-218, 225-247, 262-284, 291-313 and 323-345 637910011381 HMMPfam hit to PF03601, Conserved hypothetical protein CHP00698, score 1.2e-166 637910011382 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011383 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 637910011384 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 637910011385 AP (apurinic/apyrimidinic) site pocket; other site 637910011386 DNA interaction; other site 637910011387 Metal-binding active site; metal-binding site 637910011388 HMMPfam hit to PF01261, Xylose isomerase-type TIM barrel, score 1e-60 637910011389 PS00729 AP endonucleases family 2 signature 1. 637910011390 PS00730 AP endonucleases family 2 signature 2. 637910011391 PS00731 AP endonucleases family 2 signature 3. 637910011392 putative kinase; Provisional; Region: PRK09954 637910011393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637910011394 putative DNA binding site [nucleotide binding]; other site 637910011395 putative Zn2+ binding site [ion binding]; other site 637910011396 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 637910011397 substrate binding site [chemical binding]; other site 637910011398 ATP binding site [chemical binding]; other site 637910011399 HMMPfam hit to PF08279, Helix-turn-helix, type 11, score 0.00051 637910011400 Predicted helix-turn-helix motif with score 1281.000, SD 3.55 at aa 18-39, sequence IQQNEIADILQISRSRVAAHIM 637910011401 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 7.2e-66 637910011402 PS00583 pfkB family of carbohydrate kinases signature 1. 637910011403 PS00584 pfkB family of carbohydrate kinases signature 2. 637910011404 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 637910011405 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 637910011406 Nucleoside recognition; Region: Gate; pfam07670 637910011407 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 637910011408 8 transmembrane helices predicted for ROD22911 by TMHMM2.0 at aa 5-22, 27-49, 96-118, 173-195, 258-280, 287-309, 352-374 and 394-413 637910011409 HMMPfam hit to PF07662, Na+ dependent nucleoside transporter C-terminal, score 3.3e-99 637910011410 HMMPfam hit to PF07670, Nucleoside recognition, score 4.6e-15 637910011411 HMMPfam hit to PF01773, Na+ dependent nucleoside transporter score 2.9e-35 637910011412 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 637910011413 HMMPfam hit to PF04227, Indigoidine synthase A like protein, score 2.4e-215 637910011414 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011415 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 637910011416 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 637910011417 substrate binding site [chemical binding]; other site 637910011418 ATP binding site [chemical binding]; other site 637910011419 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 1.1e-70 637910011420 PS00584 pfkB family of carbohydrate kinases signature 2. 637910011421 PS00583 pfkB family of carbohydrate kinases signature 1. 637910011422 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 637910011423 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 637910011424 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 637910011425 active site 637910011426 P-loop; other site 637910011427 phosphorylation site [posttranslational modification] 637910011428 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 637910011429 8 transmembrane helices predicted for ROD22941 by TMHMM2.0 at aa 230-252, 272-294, 307-329, 349-368, 389-408, 428-450, 487-509 and 529-551 637910011430 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 3e-17 637910011431 HMMPfam hit to PF02379, Phosphotransferase system, fructose-specific IIB subunit, score 8e-63 637910011432 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 637910011433 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 637910011434 putative substrate binding site [chemical binding]; other site 637910011435 putative ATP binding site [chemical binding]; other site 637910011436 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 4.8e-76 637910011437 PS00584 pfkB family of carbohydrate kinases signature 2. 637910011438 PS00583 pfkB family of carbohydrate kinases signature 1. 637910011439 PS00464 Ribosomal protein L22 signature. 637910011440 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 637910011441 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637910011442 active site 637910011443 phosphorylation site [posttranslational modification] 637910011444 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 637910011445 dimerization domain swap beta strand [polypeptide binding]; other site 637910011446 regulatory protein interface [polypeptide binding]; other site 637910011447 active site 637910011448 regulatory phosphorylation site [posttranslational modification]; other site 637910011449 HMMPfam hit to PF00381, Phosphotransferase system, phosphocarrier HPr protein, score 1.6e-51 637910011450 PS00589 PTS HPR component serine phosphorylation site signature. 637910011451 PS00369 PTS HPR component histidine phosphorylation site signature. 637910011452 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 5.3e-77 637910011453 PS00372 PTS EIIA domains phosphorylation site signature 2. 637910011454 sugar efflux transporter B; Provisional; Region: PRK15011 637910011455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910011456 putative substrate translocation pore; other site 637910011457 12 transmembrane helices predicted for ROD22971 by TMHMM2.0 at aa 13-35, 50-72, 84-101, 105-124, 145-167, 172-194, 222-244, 254-276, 283-302, 306-328, 349-367 and 371-390 637910011458 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.4e-37 637910011459 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011460 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011461 Flagellin N-methylase; Region: FliB; pfam03692 637910011462 HMMPfam hit to PF03692, Protein of unknown function UPF0153, score 7e-14 637910011463 elongation factor P; Provisional; Region: PRK04542 637910011464 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 637910011465 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 637910011466 RNA binding site [nucleotide binding]; other site 637910011467 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 637910011468 RNA binding site [nucleotide binding]; other site 637910011469 HMMPfam hit to PF08207, Translation elongation factor, KOW-like, score 6.3e-29 637910011470 HMMPfam hit to PF01132, Translation elongation factor P/YeiP, central, score 2.4e-29 637910011471 HMMPfam hit to PF09285, Elongation factor P, C-terminal, score 7.5e-29 637910011472 PS01275 Elongation factor P signature. 637910011473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637910011474 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637910011475 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637910011476 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 2.7e-31 637910011477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637910011478 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637910011479 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637910011480 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.2e-27 637910011481 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 1.2e-17 637910011482 mannonate dehydratase; Provisional; Region: PRK03906 637910011483 mannonate dehydratase; Region: uxuA; TIGR00695 637910011484 HMMPfam hit to PF03786, Mannonate dehydratase, score 3.7e-260 637910011485 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 637910011486 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 637910011487 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 637910011488 HMMPfam hit to PF01232, Mannitol dehydrogenase rossman, N-terminal, score 9.6e-90 637910011489 HMMPfam hit to PF08125, Mannitol dehydrogenase, C-terminal, score 1.9e-125 637910011490 PS00974 Mannitol dehydrogenases signature. 637910011491 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 637910011492 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 637910011493 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 637910011494 HMMPfam hit to PF02492, Cobalamin (vitamin B12) biosynthesis CobW-like, score 9.4e-48 637910011495 PS00017 ATP/GTP-binding site motif A (P-loop). 637910011496 HMMPfam hit to PF07683, Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal, score 1.6e-07 637910011497 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 637910011498 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 637910011499 active site 637910011500 5 transmembrane helices predicted for ROD23051 by TMHMM2.0 at aa 9-31, 62-81, 93-115, 160-182 and 187-209 637910011501 HMMPfam hit to PF01569, Phosphatidic acid phosphatase type 2-like, score 7.7e-20 637910011502 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 637910011503 NlpC/P60 family; Region: NLPC_P60; pfam00877 637910011504 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011505 HMMPfam hit to PF00877, NLP/P60, score 1.5e-54 637910011506 phage resistance protein; Provisional; Region: PRK10551 637910011507 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 637910011508 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637910011509 2 transmembrane helices predicted for ROD23071 by TMHMM2.0 at aa 12-34 and 236-258 637910011510 HMMPfam hit to PF00563, EAL, score 1.2e-96 637910011511 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 637910011512 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 637910011513 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 4.3e-53 637910011514 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 637910011515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910011516 dimer interface [polypeptide binding]; other site 637910011517 conserved gate region; other site 637910011518 putative PBP binding loops; other site 637910011519 ABC-ATPase subunit interface; other site 637910011520 6 transmembrane helices predicted for ROD23091 by TMHMM2.0 at aa 9-31, 134-156, 169-191, 224-246, 283-305 and 329-348 637910011521 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 9.7e-58 637910011522 microcin C ABC transporter permease; Provisional; Region: PRK15021 637910011523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910011524 dimer interface [polypeptide binding]; other site 637910011525 conserved gate region; other site 637910011526 ABC-ATPase subunit interface; other site 637910011527 6 transmembrane helices predicted for ROD23101 by TMHMM2.0 at aa 21-43, 142-164, 177-199, 203-222, 254-276 and 306-328 637910011528 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.9e-47 637910011529 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910011530 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 637910011531 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637910011532 Walker A/P-loop; other site 637910011533 ATP binding site [chemical binding]; other site 637910011534 Q-loop/lid; other site 637910011535 ABC transporter signature motif; other site 637910011536 Walker B; other site 637910011537 D-loop; other site 637910011538 H-loop/switch region; other site 637910011539 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 637910011540 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637910011541 Walker A/P-loop; other site 637910011542 ATP binding site [chemical binding]; other site 637910011543 Q-loop/lid; other site 637910011544 ABC transporter signature motif; other site 637910011545 Walker B; other site 637910011546 D-loop; other site 637910011547 H-loop/switch region; other site 637910011548 HMMPfam hit to PF00005, ABC transporter related, score 2e-61 637910011549 PS00017 ATP/GTP-binding site motif A (P-loop). 637910011550 PS00211 ABC transporters family signature. 637910011551 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter C-terminal, score 0.00037 637910011552 HMMPfam hit to PF00005, ABC transporter related, score 8.3e-61 637910011553 PS00017 ATP/GTP-binding site motif A (P-loop). 637910011554 PS00211 ABC transporters family signature. 637910011555 hypothetical protein; Provisional; Region: PRK11835 637910011556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910011557 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 637910011558 putative substrate translocation pore; other site 637910011559 12 transmembrane helices predicted for ROD23131 by TMHMM2.0 at aa 7-26, 41-63, 76-98, 102-124, 137-159, 163-185, 219-241, 251-273, 286-308, 313-332, 344-366 and 370-389 637910011560 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1e-56 637910011561 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011562 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011563 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 637910011564 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637910011565 RNA binding surface [nucleotide binding]; other site 637910011566 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 637910011567 active site 637910011568 uracil binding [chemical binding]; other site 637910011569 HMMPfam hit to PF00849, Pseudouridine synthase, score 6.4e-28 637910011570 PS01149 Rsu family of pseudouridine synthase signature. 637910011571 HMMPfam hit to PF01479, RNA-binding S4, score 3.4e-10 637910011572 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 637910011573 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637910011574 ATP binding site [chemical binding]; other site 637910011575 putative Mg++ binding site [ion binding]; other site 637910011576 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637910011577 nucleotide binding region [chemical binding]; other site 637910011578 ATP-binding site [chemical binding]; other site 637910011579 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 637910011580 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/type III, Res subunit, score 1.6e-42 637910011581 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 7.5e-14 637910011582 PS00017 ATP/GTP-binding site motif A (P-loop). 637910011583 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 637910011584 5S rRNA interface [nucleotide binding]; other site 637910011585 CTC domain interface [polypeptide binding]; other site 637910011586 L16 interface [polypeptide binding]; other site 637910011587 HMMPfam hit to PF01386, Ribosomal protein L25, score 9e-48 637910011588 Nucleoid-associated protein [General function prediction only]; Region: COG3081 637910011589 nucleoid-associated protein NdpA; Validated; Region: PRK00378 637910011590 HMMPfam hit to PF04245, 37kDa nucleoid-associated bacterial protein, score 1.1e-172 637910011591 hypothetical protein; Provisional; Region: PRK13689 637910011592 HMMPfam hit to PF07208, Protein of unknown function DUF1414, score 2.8e-51 637910011593 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 637910011594 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 637910011595 Sulfatase; Region: Sulfatase; cl17466 637910011596 PS00430 TonB-dependent receptor proteins signature 1. 637910011597 5 transmembrane helices predicted for ROD23201 by TMHMM2.0 at aa 21-43, 58-80, 85-103, 135-157 and 169-191 637910011598 HMMPfam hit to PF00884, Sulphatase, score 2.7e-68 637910011599 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 637910011600 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 637910011601 active site 637910011602 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 8.2e-47 637910011603 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 637910011604 trimer interface [polypeptide binding]; other site 637910011605 active site 637910011606 substrate binding site [chemical binding]; other site 637910011607 CoA binding site [chemical binding]; other site 637910011608 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 75 637910011609 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 11 637910011610 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 5.6 637910011611 transcriptional regulator NarP; Provisional; Region: PRK10403 637910011612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910011613 active site 637910011614 phosphorylation site [posttranslational modification] 637910011615 intermolecular recognition site; other site 637910011616 dimerization interface [polypeptide binding]; other site 637910011617 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910011618 DNA binding residues [nucleotide binding] 637910011619 dimerization interface [polypeptide binding]; other site 637910011620 HMMPfam hit to PF00072, Response regulator receiver, score 6.4e-43 637910011621 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 1.6e-29 637910011622 PS00622 Bacterial regulatory proteins, luxR family signature. 637910011623 Predicted helix-turn-helix motif with score 1668.000, SD 4.87 at aa 169-190, sequence LSNKQIASVLNISEQTVKVHIR 637910011624 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 637910011625 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 637910011626 2 transmembrane helices predicted for ROD23251 by TMHMM2.0 at aa 99-121 and 147-169 637910011627 HMMPfam hit to PF03918, Cytochrome C biogenesis protein, score 6.8e-79 637910011628 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 637910011629 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 637910011630 catalytic residues [active] 637910011631 central insert; other site 637910011632 HMMPfam hit to PF08534, Redoxin, score 1.7e-23 637910011633 PS00194 Thioredoxin family active site. 637910011634 1 transmembrane helix predicted for ROD23261 by TMHMM2.0 at aa 5-24 637910011635 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 637910011636 15 transmembrane helices predicted for ROD23271 by TMHMM2.0 at aa 6-28, 41-63, 95-114, 121-143, 176-198, 211-233, 248-265, 277-299, 314-332, 353-375, 390-412, 425-444, 448-470, 482-504 and 610-629 637910011637 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011638 HMMPfam hit to PF01578, Cytochrome c assembly protein, score 4.3e-88 637910011639 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 637910011640 HMMPfam hit to PF03100, CcmE/CycJ protein, score 5.3e-92 637910011641 1 transmembrane helix predicted for ROD23281 by TMHMM2.0 at aa 7-29 637910011642 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 637910011643 HMMPfam hit to PF04995, Heme exporter protein D (CcmD), score 2.7e-19 637910011644 1 transmembrane helix predicted for ROD23291 by TMHMM2.0 at aa 15-37 637910011645 heme exporter protein CcmC; Region: ccmC; TIGR01191 637910011646 6 transmembrane helices predicted for ROD23301 by TMHMM2.0 at aa 21-43, 63-85, 92-114, 129-148, 155-177 and 204-226 637910011647 HMMPfam hit to PF01578, Cytochrome c assembly protein, score 5.1e-60 637910011648 heme exporter protein CcmB; Region: ccmB; TIGR01190 637910011649 HMMPfam hit to PF03379, Cytochrome c-type biogenesis protein CcmB, score 6.8e-127 637910011650 6 transmembrane helices predicted for ROD23311 by TMHMM2.0 at aa 20-39, 43-65, 96-118, 128-150, 157-179 and 194-216 637910011651 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 637910011652 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 637910011653 Walker A/P-loop; other site 637910011654 ATP binding site [chemical binding]; other site 637910011655 Q-loop/lid; other site 637910011656 ABC transporter signature motif; other site 637910011657 Walker B; other site 637910011658 D-loop; other site 637910011659 H-loop/switch region; other site 637910011660 HMMPfam hit to PF00005, ABC transporter related, score 1.8e-51 637910011661 PS00211 ABC transporters family signature. 637910011662 PS00017 ATP/GTP-binding site motif A (P-loop). 637910011663 cytochrome c-type protein NapC; Provisional; Region: PRK10617 637910011664 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 637910011665 HMMPfam hit to PF03264, NapC/NirT cytochrome c, N-terminal, score 4.2e-125 637910011666 PS00190 Cytochrome c family heme-binding site signature. 637910011667 PS00190 Cytochrome c family heme-binding site signature. 637910011668 PS00190 Cytochrome c family heme-binding site signature. 637910011669 1 transmembrane helix predicted for ROD23331 by TMHMM2.0 at aa 21-43 637910011670 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 637910011671 HMMPfam hit to PF03892, Nitrate reductase cytochrome c-type subunit (NapB), score 1.2e-53 637910011672 PS00190 Cytochrome c family heme-binding site signature. 637910011673 PS00190 Cytochrome c family heme-binding site signature. 637910011674 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 637910011675 4Fe-4S binding domain; Region: Fer4_5; pfam12801 637910011676 4Fe-4S binding domain; Region: Fer4_6; pfam12837 637910011677 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.00044 637910011678 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910011679 4 transmembrane helices predicted for ROD23351 by TMHMM2.0 at aa 30-52, 78-100, 138-160 and 170-192 637910011680 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 637910011681 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0022 637910011682 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 3.1e-05 637910011683 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910011684 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 637910011685 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 637910011686 [4Fe-4S] binding site [ion binding]; other site 637910011687 molybdopterin cofactor binding site; other site 637910011688 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 637910011689 molybdopterin cofactor binding site; other site 637910011690 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 6.2e-34 637910011691 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 7.4e-138 637910011692 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 1.3e-23 637910011693 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 637910011694 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 637910011695 HMMPfam hit to PF03927, NapD, score 6e-36 637910011696 ferredoxin-type protein; Provisional; Region: PRK10194 637910011697 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 3.5e-06 637910011698 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910011699 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.00095 637910011700 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910011701 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0016 637910011702 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910011703 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 637910011704 secondary substrate binding site; other site 637910011705 primary substrate binding site; other site 637910011706 inhibition loop; other site 637910011707 dimerization interface [polypeptide binding]; other site 637910011708 HMMPfam hit to PF03974, Proteinase inhibitor I11, ecotin, score 7.2e-128 637910011709 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011710 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 637910011711 Predicted dehydrogenase [General function prediction only]; Region: COG0579 637910011712 malate:quinone oxidoreductase; Validated; Region: PRK05257 637910011713 HMMPfam hit to PF06039, Malate:quinone-oxidoreductase, score 0 637910011714 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 637910011715 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 637910011716 Sulfate transporter family; Region: Sulfate_transp; pfam00916 637910011717 11 transmembrane helices predicted for ROD23421 by TMHMM2.0 at aa 30-52, 59-81, 101-120, 127-149, 159-176, 183-205, 220-242, 273-295, 305-322, 329-351 and 371-393 637910011718 HMMPfam hit to PF00916, Sulphate transporter score 8e-63 637910011719 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011720 MgtE intracellular N domain; Region: MgtE_N; cl15244 637910011721 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 637910011722 MgtE intracellular N domain; Region: MgtE_N; smart00924 637910011723 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 637910011724 Divalent cation transporter; Region: MgtE; cl00786 637910011725 3 transmembrane helices predicted for ROD23431 by TMHMM2.0 at aa 389-411, 418-440 and 455-477 637910011726 HMMPfam hit to PF01769, MgtE integral membrane region, score 2.5e-13 637910011727 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 1e-12 637910011728 HMMPfam hit to PF03448, MgtE intracellular region, score 1.1e-29 637910011729 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 637910011730 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 637910011731 Walker A/P-loop; other site 637910011732 ATP binding site [chemical binding]; other site 637910011733 Q-loop/lid; other site 637910011734 ABC transporter signature motif; other site 637910011735 Walker B; other site 637910011736 D-loop; other site 637910011737 H-loop/switch region; other site 637910011738 HMMPfam hit to PF00005, ABC transporter related, score 1.1e-44 637910011739 PS00211 ABC transporters family signature. 637910011740 PS00017 ATP/GTP-binding site motif A (P-loop). 637910011741 6 transmembrane helices predicted for ROD23441 by TMHMM2.0 at aa 13-35, 50-72, 122-144, 149-171, 231-253 and 268-290 637910011742 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 637910011743 HMMPfam hit to PF03171, 2OG-Fe(II) oxygenase, score 5.1e-09 637910011744 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 637910011745 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 637910011746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910011747 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 637910011748 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 637910011749 DNA binding site [nucleotide binding] 637910011750 active site 637910011751 HMMPfam hit to PF01035, Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding, score 2.2e-50 637910011752 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 637910011753 HMMPfam hit to PF02870, Methylguanine DNA methyltransferase, ribonuclease-like, score 2.5e-18 637910011754 PS00435 Peroxidases proximal heme-ligand signature. 637910011755 PS00041 Bacterial regulatory proteins, araC family signature. 637910011756 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 1.6e-13 637910011757 PS00041 Bacterial regulatory proteins, araC family signature. 637910011758 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 100-121, sequence IALAALAQQVAMSPYHFHRLFK 637910011759 HMMPfam hit to PF02805, Ada, metal-binding, score 6.3e-43 637910011760 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 637910011761 ApbE family; Region: ApbE; pfam02424 637910011762 HMMPfam hit to PF02424, ApbE-like lipoprotein, score 2.9e-150 637910011763 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011764 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 637910011765 outer membrane porin protein C; Provisional; Region: PRK10554 637910011766 HMMPfam hit to PF00267, Porin, Gram-negative type, score 2.2e-197 637910011767 PS00576 General diffusion Gram-negative porins signature. 637910011768 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 637910011769 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 637910011770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910011771 ATP binding site [chemical binding]; other site 637910011772 Mg2+ binding site [ion binding]; other site 637910011773 G-X-G motif; other site 637910011774 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 637910011775 putative binding surface; other site 637910011776 active site 637910011777 2 transmembrane helices predicted for ROD23491 by TMHMM2.0 at aa 20-42 and 308-330 637910011778 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 4e-13 637910011779 HMMPfam hit to PF01627, Hpt, score 2.7e-15 637910011780 transcriptional regulator RcsB; Provisional; Region: PRK10840 637910011781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910011782 active site 637910011783 phosphorylation site [posttranslational modification] 637910011784 intermolecular recognition site; other site 637910011785 dimerization interface [polypeptide binding]; other site 637910011786 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910011787 DNA binding residues [nucleotide binding] 637910011788 dimerization interface [polypeptide binding]; other site 637910011789 HMMPfam hit to PF00072, Response regulator receiver, score 1.5e-33 637910011790 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 6e-22 637910011791 PS00622 Bacterial regulatory proteins, luxR family signature. 637910011792 Predicted helix-turn-helix motif with score 1130.000, SD 3.04 at aa 166-187, sequence FLVTEIAKKLNRSIKTISSQKK 637910011793 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 637910011794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637910011795 dimer interface [polypeptide binding]; other site 637910011796 phosphorylation site [posttranslational modification] 637910011797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910011798 ATP binding site [chemical binding]; other site 637910011799 Mg2+ binding site [ion binding]; other site 637910011800 G-X-G motif; other site 637910011801 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 637910011802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910011803 active site 637910011804 phosphorylation site [posttranslational modification] 637910011805 intermolecular recognition site; other site 637910011806 dimerization interface [polypeptide binding]; other site 637910011807 HMMPfam hit to PF00072, Response regulator receiver, score 2.6e-42 637910011808 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.1e-43 637910011809 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.2e-21 637910011810 1 transmembrane helix predicted for ROD23521 by TMHMM2.0 at aa 245-264 637910011811 DNA gyrase subunit A; Validated; Region: PRK05560 637910011812 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 637910011813 CAP-like domain; other site 637910011814 active site 637910011815 primary dimer interface [polypeptide binding]; other site 637910011816 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637910011817 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637910011818 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637910011819 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637910011820 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637910011821 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637910011822 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 9e-14 637910011823 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 7.1e-15 637910011824 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 3.4e-16 637910011825 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 3.3e-10 637910011826 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 2.3e-15 637910011827 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 4.3e-13 637910011828 HMMPfam hit to PF00521, DNA topoisomerase, type IIA, subunit A or C-terminal, score 0 637910011829 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 637910011830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910011831 S-adenosylmethionine binding site [chemical binding]; other site 637910011832 HMMPfam hit to PF08241, Methyltransferase type 11, score 3.9e-28 637910011833 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 637910011834 ATP cone domain; Region: ATP-cone; pfam03477 637910011835 Class I ribonucleotide reductase; Region: RNR_I; cd01679 637910011836 active site 637910011837 dimer interface [polypeptide binding]; other site 637910011838 catalytic residues [active] 637910011839 effector binding site; other site 637910011840 R2 peptide binding site; other site 637910011841 HMMPfam hit to PF03477, ATP-cone, score 5.3e-23 637910011842 HMMPfam hit to PF00317, Ribonucleotide reductase large subunit, N-terminal, score 6.1e-24 637910011843 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011844 HMMPfam hit to PF02867, Ribonucleotide reductase large subunit, C-terminal, score 6.6e-272 637910011845 PS00089 Ribonucleotide reductase large subunit signature. 637910011846 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 637910011847 dimer interface [polypeptide binding]; other site 637910011848 putative radical transfer pathway; other site 637910011849 diiron center [ion binding]; other site 637910011850 tyrosyl radical; other site 637910011851 PS00368 Ribonucleotide reductase small subunit signature. 637910011852 HMMPfam hit to PF00268, Ribonucleotide reductase, score 2.7e-10 637910011853 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 637910011854 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637910011855 catalytic loop [active] 637910011856 iron binding site [ion binding]; other site 637910011857 HMMPfam hit to PF00111, Ferredoxin, score 1.7e-15 637910011858 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 637910011859 4 transmembrane helices predicted for ROD23601 by TMHMM2.0 at aa 21-43, 53-75, 80-102 and 106-128 637910011860 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910011861 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910011862 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910011863 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910011864 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910011865 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910011866 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910011867 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910011868 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910011869 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910011870 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910011871 Transposase; Region: HTH_Tnp_1; pfam01527 637910011872 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910011873 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910011874 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910011875 pseudogene, N-terminus deleted by ISCro1, fragment 637910011876 3 transmembrane helices predicted for ROD23651 by TMHMM2.0 at aa 15-32, 45-70 and 85-107 637910011877 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910011878 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910011879 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 637910011880 putative dimerization interface [polypeptide binding]; other site 637910011881 HMMPfam hit to PF03466, LysR, substrate-binding, score 7.3e-52 637910011882 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 8.5e-23 637910011883 PS00044 Bacterial regulatory proteins, lysR family signature. 637910011884 Predicted helix-turn-helix motif with score 1577.000, SD 4.56 at aa 18-39, sequence KSFSRAGECIGLSQSAVSHSIK 637910011885 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 637910011886 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 637910011887 9 transmembrane helices predicted for ROD23681 by TMHMM2.0 at aa 7-24, 29-48, 69-91, 101-123, 130-152, 167-189, 202-224, 229-251 and 272-294 637910011888 HMMPfam hit to PF01758, Bile acid:sodium symporter, score 0.00058 637910011889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 637910011890 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 637910011891 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 637910011892 nucleotide binding pocket [chemical binding]; other site 637910011893 K-X-D-G motif; other site 637910011894 catalytic site [active] 637910011895 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 637910011896 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 637910011897 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 637910011898 Dimer interface [polypeptide binding]; other site 637910011899 BRCT sequence motif; other site 637910011900 HMMPfam hit to PF00533, BRCT, score 1.1e-20 637910011901 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 5e-06 637910011902 HMMPfam hit to PF03119, Zinc-finger, NAD-dependent DNA ligase C4-type, score 1.8e-11 637910011903 HMMPfam hit to PF03120, NAD-dependent DNA ligase, OB-fold, score 4.8e-53 637910011904 PS01056 NAD-dependent DNA ligase signature 2. 637910011905 HMMPfam hit to PF01653, NAD-dependent DNA ligase, adenylation, score 7.7e-218 637910011906 PS01055 NAD-dependent DNA ligase signature 1. 637910011907 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 637910011908 cell division protein ZipA; Provisional; Region: PRK03427 637910011909 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 637910011910 FtsZ protein binding site [polypeptide binding]; other site 637910011911 HMMPfam hit to PF04354, ZipA, C-terminal FtsZ-binding region, score 2.7e-89 637910011912 1 transmembrane helix predicted for ROD23711 by TMHMM2.0 at aa 5-27 637910011913 putative sulfate transport protein CysZ; Validated; Region: PRK04949 637910011914 4 transmembrane helices predicted for ROD23721 by TMHMM2.0 at aa 31-53, 68-90, 151-173 and 220-242 637910011915 HMMPfam hit to PF04401, Protein of unknown function DUF540, score 1e-110 637910011916 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 637910011917 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 637910011918 dimer interface [polypeptide binding]; other site 637910011919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910011920 catalytic residue [active] 637910011921 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 2.3e-127 637910011922 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 637910011923 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 637910011924 dimerization domain swap beta strand [polypeptide binding]; other site 637910011925 regulatory protein interface [polypeptide binding]; other site 637910011926 active site 637910011927 regulatory phosphorylation site [posttranslational modification]; other site 637910011928 HMMPfam hit to PF00381, Phosphotransferase system, phosphocarrier HPr protein, score 5.7e-49 637910011929 PS00369 PTS HPR component histidine phosphorylation site signature. 637910011930 PS00589 PTS HPR component serine phosphorylation site signature. 637910011931 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 637910011932 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 637910011933 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 637910011934 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 637910011935 HMMPfam hit to PF05524, Phosphotransferase system, PEP-utilising enzyme, N-terminal, score 1.4e-59 637910011936 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile region, score 4.4e-36 637910011937 PS00370 PEP-utilizing enzymes phosphorylation site signature. 637910011938 HMMPfam hit to PF02896, PEP-utilizing enzyme, score 1.9e-193 637910011939 PS00742 PEP-utilizing enzymes signature 2. 637910011940 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 637910011941 HPr interaction site; other site 637910011942 glycerol kinase (GK) interaction site [polypeptide binding]; other site 637910011943 active site 637910011944 phosphorylation site [posttranslational modification] 637910011945 HMMPfam hit to PF00358, Phosphotransferase system, sugar-specific permease EIIA 1 domain, score 1e-80 637910011946 PS00371 PTS EIIA domains phosphorylation site signature 1. 637910011947 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 637910011948 dimer interface [polypeptide binding]; other site 637910011949 pyridoxamine kinase; Validated; Region: PRK05756 637910011950 pyridoxal binding site [chemical binding]; other site 637910011951 ATP binding site [chemical binding]; other site 637910011952 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 0.00035 637910011953 pseudogene, truncated by frameshift mutation 637910011954 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 6.5e-23 637910011955 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 1.1e-08 637910011956 Protein of unknown function (DUF2659); Region: DUF2659; pfam10858 637910011957 cysteine synthase B; Region: cysM; TIGR01138 637910011958 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 637910011959 dimer interface [polypeptide binding]; other site 637910011960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910011961 catalytic residue [active] 637910011962 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 6.5e-111 637910011963 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 637910011964 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 637910011965 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 637910011966 Walker A/P-loop; other site 637910011967 ATP binding site [chemical binding]; other site 637910011968 Q-loop/lid; other site 637910011969 ABC transporter signature motif; other site 637910011970 Walker B; other site 637910011971 D-loop; other site 637910011972 H-loop/switch region; other site 637910011973 TOBE-like domain; Region: TOBE_3; pfam12857 637910011974 HMMPfam hit to PF00005, ABC transporter related, score 2.9e-73 637910011975 PS00211 ABC transporters family signature. 637910011976 PS00017 ATP/GTP-binding site motif A (P-loop). 637910011977 sulfate transport protein; Provisional; Region: cysT; CHL00187 637910011978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910011979 dimer interface [polypeptide binding]; other site 637910011980 conserved gate region; other site 637910011981 putative PBP binding loops; other site 637910011982 ABC-ATPase subunit interface; other site 637910011983 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 5.4e-18 637910011984 6 transmembrane helices predicted for ROD23841 by TMHMM2.0 at aa 20-42, 68-90, 103-125, 140-162, 201-223 and 246-268 637910011985 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910011986 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 637910011987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910011988 dimer interface [polypeptide binding]; other site 637910011989 conserved gate region; other site 637910011990 putative PBP binding loops; other site 637910011991 ABC-ATPase subunit interface; other site 637910011992 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 6.3e-34 637910011993 7 transmembrane helices predicted for ROD23851 by TMHMM2.0 at aa 15-37, 62-84, 104-126, 138-160, 188-205, 212-234 and 244-266 637910011994 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910011995 thiosulfate transporter subunit; Provisional; Region: PRK10852 637910011996 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 637910011997 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 1.7e-11 637910011998 PS00757 Prokaryotic sulfate-binding proteins signature 2. 637910011999 PS00401 Prokaryotic sulfate-binding proteins signature 1. 637910012000 PS00092 N-6 Adenine-specific DNA methylases signature. 637910012001 short chain dehydrogenase; Provisional; Region: PRK08226 637910012002 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 637910012003 NAD binding site [chemical binding]; other site 637910012004 homotetramer interface [polypeptide binding]; other site 637910012005 homodimer interface [polypeptide binding]; other site 637910012006 active site 637910012007 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 4.5e-37 637910012008 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 637910012009 HMMPfam hit to PF04261, Dyp-type peroxidase, score 6.8e-159 637910012010 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 637910012011 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 637910012012 HMMPfam hit to PF06572, Protein of unknown function DUF1131, score 5.8e-154 637910012013 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012014 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 637910012015 4 transmembrane helices predicted for ROD23901 by TMHMM2.0 at aa 21-40, 60-79, 86-108 and 118-135 637910012016 putative acetyltransferase; Provisional; Region: PRK03624 637910012017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637910012018 Coenzyme A binding pocket [chemical binding]; other site 637910012019 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2.6e-22 637910012020 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 637910012021 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 637910012022 active site 637910012023 metal binding site [ion binding]; metal-binding site 637910012024 HMMPfam hit to PF01520, Cell wall hydrolase/autolysin, catalytic, score 2.5e-106 637910012025 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 637910012026 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 637910012027 HMMPfam hit to PF01218, Coproporphyrinogen III oxidase, score 3.6e-243 637910012028 PS01021 Coproporphyrinogen III oxidase signature. 637910012029 transcriptional regulator EutR; Provisional; Region: PRK10130 637910012030 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910012031 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910012032 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 5.1e-05 637910012033 PS00041 Bacterial regulatory proteins, araC family signature. 637910012034 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 7.6e-10 637910012035 Predicted helix-turn-helix motif with score 1361.000, SD 3.82 at aa 257-278, sequence LTVLDLCNQLHVSRRTLQNAFH 637910012036 carboxysome structural protein EutK; Provisional; Region: PRK15466 637910012037 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 637910012038 Hexamer interface [polypeptide binding]; other site 637910012039 Hexagonal pore residue; other site 637910012040 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 3.1e-31 637910012041 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 637910012042 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 637910012043 putative hexamer interface [polypeptide binding]; other site 637910012044 putative hexagonal pore; other site 637910012045 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 637910012046 putative hexamer interface [polypeptide binding]; other site 637910012047 putative hexagonal pore; other site 637910012048 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 2.1e-13 637910012049 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 637910012050 HMMPfam hit to PF05985, Ethanolamine ammonia-lyase light chain, score 5.5e-150 637910012051 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 637910012052 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 637910012053 HMMPfam hit to PF06751, Ethanolamine ammonia lyase large subunit, score 0 637910012054 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012055 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012056 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 637910012057 HMMPfam hit to PF06277, Ethanolamine utilisation EutA, score 0 637910012058 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 637910012059 HMMPfam hit to PF04346, Ethanolamine utilisation protein, EutH, score 1.3e-267 637910012060 10 transmembrane helices predicted for ROD24001 by TMHMM2.0 at aa 7-29, 58-80, 87-109, 124-146, 153-175, 190-212, 231-253, 273-295, 342-364 and 369-391 637910012061 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012062 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 637910012063 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 637910012064 active site 637910012065 metal binding site [ion binding]; metal-binding site 637910012066 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 2.9e-190 637910012067 PS00060 Iron-containing alcohol dehydrogenases signature 2. 637910012068 PS00913 Iron-containing alcohol dehydrogenases signature 1. 637910012069 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012070 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 637910012071 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637910012072 nucleotide binding site [chemical binding]; other site 637910012073 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 637910012074 putative catalytic cysteine [active] 637910012075 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 8.9e-10 637910012076 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 637910012077 Hexamer/Pentamer interface [polypeptide binding]; other site 637910012078 central pore; other site 637910012079 HMMPfam hit to PF03319, Ethanolamine utilization protein EutN/carboxysome structural protein Ccml, score 2.3e-50 637910012080 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 637910012081 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 637910012082 Hexamer interface [polypeptide binding]; other site 637910012083 Hexagonal pore residue; other site 637910012084 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 8.6e-40 637910012085 PS01139 Bacterial microcompartiments proteins signature. 637910012086 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 637910012087 HMMPfam hit to PF01515, Phosphate acetyl/butaryl transferase, score 5.5e-164 637910012088 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 637910012089 HMMPfam hit to PF01923, Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase, score 2.4e-37 637910012090 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 637910012091 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 637910012092 HMMPfam hit to PF06249, Ethanolamine utilisation EutQ, score 1.2e-103 637910012093 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 637910012094 G1 box; other site 637910012095 GTP/Mg2+ binding site [chemical binding]; other site 637910012096 G2 box; other site 637910012097 Switch I region; other site 637910012098 G3 box; other site 637910012099 Switch II region; other site 637910012100 G4 box; other site 637910012101 G5 box; other site 637910012102 PS00017 ATP/GTP-binding site motif A (P-loop). 637910012103 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 637910012104 putative hexamer interface [polypeptide binding]; other site 637910012105 putative hexagonal pore; other site 637910012106 HMMPfam hit to PF00936, Bacterial microcompartments protein, score 9.9e-16 637910012107 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 637910012108 Malic enzyme, N-terminal domain; Region: malic; pfam00390 637910012109 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 637910012110 putative NAD(P) binding site [chemical binding]; other site 637910012111 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 637910012112 HMMPfam hit to PF01515, Phosphate acetyl/butaryl transferase, score 4.1e-118 637910012113 HMMPfam hit to PF03949, Malic enzyme, NAD-binding, score 8.6e-129 637910012114 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012115 HMMPfam hit to PF00390, Malic enzyme, N-terminal, score 9.2e-77 637910012116 transaldolase-like protein; Provisional; Region: PTZ00411 637910012117 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 637910012118 active site 637910012119 dimer interface [polypeptide binding]; other site 637910012120 catalytic residue [active] 637910012121 HMMPfam hit to PF00923, Transaldolase, score 3e-184 637910012122 PS01054 Transaldolase signature 1. 637910012123 PS00958 Transaldolase active site. 637910012124 transketolase; Reviewed; Region: PRK12753 637910012125 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637910012126 TPP-binding site [chemical binding]; other site 637910012127 dimer interface [polypeptide binding]; other site 637910012128 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637910012129 PYR/PP interface [polypeptide binding]; other site 637910012130 dimer interface [polypeptide binding]; other site 637910012131 TPP binding site [chemical binding]; other site 637910012132 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637910012133 HMMPfam hit to PF00456, Transketolase, N-terminal, score 2.7e-256 637910012134 PS00801 Transketolase signature 1. 637910012135 HMMPfam hit to PF02779, Transketolase, central region, score 7.3e-72 637910012136 PS00802 Transketolase signature 2. 637910012137 HMMPfam hit to PF02780, Transketolase, C-terminal, score 1.4e-15 637910012138 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 637910012139 HMMPfam hit to PF06674, Protein of unknown function DUF1176, score 1.3e-184 637910012140 PS00687 Aldehyde dehydrogenases glutamic acid active site. 637910012141 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 637910012142 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 637910012143 dimer interface [polypeptide binding]; other site 637910012144 ADP-ribose binding site [chemical binding]; other site 637910012145 active site 637910012146 nudix motif; other site 637910012147 metal binding site [ion binding]; metal-binding site 637910012148 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 1.4e-18 637910012149 PS00017 ATP/GTP-binding site motif A (P-loop). 637910012150 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 637910012151 4Fe-4S binding domain; Region: Fer4; pfam00037 637910012152 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637910012153 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637910012154 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 6.5e-22 637910012155 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 0.0049 637910012156 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012157 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 4.6e-07 637910012158 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910012159 PS00190 Cytochrome c family heme-binding site signature. 637910012160 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 637910012161 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 637910012162 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637910012163 dimerization interface [polypeptide binding]; other site 637910012164 Histidine kinase; Region: HisKA_3; pfam07730 637910012165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910012166 ATP binding site [chemical binding]; other site 637910012167 Mg2+ binding site [ion binding]; other site 637910012168 G-X-G motif; other site 637910012169 2 transmembrane helices predicted for ROD24171 by TMHMM2.0 at aa 15-37 and 147-169 637910012170 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 4.6e-14 637910012171 HMMPfam hit to PF07730, Histidine kinase, dimerisation and phosphoacceptor region, score 2.9e-20 637910012172 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.1e-19 637910012173 pseudogene, truncated by premature stop codon 637910012174 HMMPfam hit to PF00873, Acriflavin resistance protein, score 0 637910012175 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 637910012176 ArsC family; Region: ArsC; pfam03960 637910012177 putative catalytic residues [active] 637910012178 HMMPfam hit to PF03960, Arsenate reductase and related, score 7.7e-49 637910012179 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 637910012180 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 637910012181 metal binding site [ion binding]; metal-binding site 637910012182 dimer interface [polypeptide binding]; other site 637910012183 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 637910012184 HMMPfam hit to PF01546, Peptidase M20, score 5.9e-54 637910012185 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 637910012186 HMMPfam hit to PF07687, Peptidase M20, dimerisation, score 3e-33 637910012187 hypothetical protein; Provisional; Region: PRK13664 637910012188 1 transmembrane helix predicted for ROD24211 by TMHMM2.0 at aa 5-24 637910012189 putative hydrolase; Provisional; Region: PRK11460 637910012190 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 637910012191 HMMPfam hit to PF02230, Phospholipase/Carboxylesterase, score 1.5e-64 637910012192 PS00217 Sugar transport proteins signature 2. 637910012193 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 637910012194 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 637910012195 Helicase; Region: Helicase_RecD; pfam05127 637910012196 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 637910012197 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 637910012198 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 0.0003 637910012199 HMMPfam hit to PF05127, Protein of unknown function DUF699, ATPase , score 3.2e-60 637910012200 PS00017 ATP/GTP-binding site motif A (P-loop). 637910012201 Predicted metalloprotease [General function prediction only]; Region: COG2321 637910012202 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 637910012203 HMMPfam hit to PF04228, Protein of unknown function, zinc metallopeptidase , score 1.9e-245 637910012204 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 637910012205 1 transmembrane helix predicted for ROD24241 by TMHMM2.0 at aa 37-59 637910012206 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 637910012207 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 637910012208 ATP binding site [chemical binding]; other site 637910012209 active site 637910012210 substrate binding site [chemical binding]; other site 637910012211 HMMPfam hit to PF01259, SAICAR synthetase, score 2.9e-126 637910012212 PS01058 SAICAR synthetase signature 2. 637910012213 PS01057 SAICAR synthetase signature 1. 637910012214 lipoprotein; Provisional; Region: PRK11679 637910012215 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 637910012216 HMMPfam hit to PF06804, NlpBDapX lipoprotein, score 4.9e-197 637910012217 PS00572 Glycosyl hydrolases family 1 active site. 637910012218 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012219 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 637910012220 dihydrodipicolinate synthase; Region: dapA; TIGR00674 637910012221 dimer interface [polypeptide binding]; other site 637910012222 active site 637910012223 catalytic residue [active] 637910012224 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase, score 4e-169 637910012225 PS00666 Dihydrodipicolinate synthetase signature 2. 637910012226 PS00665 Dihydrodipicolinate synthetase signature 1. 637910012227 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 637910012228 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 637910012229 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 637910012230 HMMPfam hit to PF01842, Amino acid-binding ACT, score 0.00019 637910012231 HMMPfam hit to PF01842, Amino acid-binding ACT, score 1.6e-05 637910012232 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 637910012233 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 637910012234 catalytic triad [active] 637910012235 HMMPfam hit to PF00578, Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen, score 6.2e-50 637910012236 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012237 isoaspartyl dipeptidase; Provisional; Region: PRK10657 637910012238 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 637910012239 active site 637910012240 HMMPfam hit to PF01979, Amidohydrolase 1, score 8.7e-06 637910012241 hypothetical protein; Provisional; Region: PRK10519 637910012242 3 transmembrane helices predicted for ROD24311 by TMHMM2.0 at aa 20-42, 69-91 and 130-152 637910012243 HMMPfam hit to PF07670, Nucleoside recognition, score 7.3e-14 637910012244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 637910012245 Nucleoside recognition; Region: Gate; pfam07670 637910012246 HMMPfam hit to PF07670, Nucleoside recognition, score 3.2e-14 637910012247 4 transmembrane helices predicted for ROD24321 by TMHMM2.0 at aa 29-48, 93-115, 128-147 and 195-217 637910012248 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012249 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 637910012250 Domain of unknown function DUF20; Region: UPF0118; pfam01594 637910012251 HMMPfam hit to PF01594, Protein of unknown function UPF0118, score 2.1e-102 637910012252 7 transmembrane helices predicted for ROD24331 by TMHMM2.0 at aa 20-51, 71-93, 155-177, 217-236, 251-273, 278-300 and 310-332 637910012253 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 637910012254 Peptidase family M48; Region: Peptidase_M48; cl12018 637910012255 HMMPfam hit to PF01435, Peptidase M48, Ste24p, score 5.7e-30 637910012256 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 637910012257 ArsC family; Region: ArsC; pfam03960 637910012258 catalytic residues [active] 637910012259 HMMPfam hit to PF03960, Arsenate reductase and related, score 9.7e-51 637910012260 pseudogene, C-terminus missing, fragment 637910012261 HMMPfam hit to PF04754, Transposase (), YhgA-like, score 4.7e-109 637910012262 pseudogene, N-terminus missing, fragment 637910012263 HMMPfam hit to PF04754, Transposase (), YhgA-like, score 2.5e-10 637910012264 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 637910012265 DNA replication initiation factor; Provisional; Region: PRK08084 637910012266 HMMPfam hit to PF00308, Chromosomal replication initiator, DnaA, score 1.1e-06 637910012267 uracil transporter; Provisional; Region: PRK10720 637910012268 12 transmembrane helices predicted for ROD24401 by TMHMM2.0 at aa 13-35, 39-61, 68-85, 89-108, 121-143, 158-180, 185-207, 227-249, 304-326, 331-353, 365-387 and 392-411 637910012269 HMMPfam hit to PF00860, Xanthine/uracil/vitamin C permease, score 1.2e-144 637910012270 PS01116 Xanthine/uracil permeases family signature. 637910012271 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012272 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637910012273 active site 637910012274 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 7.4e-13 637910012275 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 637910012276 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 637910012277 dimerization interface [polypeptide binding]; other site 637910012278 putative ATP binding site [chemical binding]; other site 637910012279 HMMPfam hit to PF00586, AIR synthase related protein, score 8e-75 637910012280 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 1.2e-50 637910012281 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 637910012282 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 637910012283 active site 637910012284 substrate binding site [chemical binding]; other site 637910012285 cosubstrate binding site; other site 637910012286 catalytic site [active] 637910012287 HMMPfam hit to PF00551, Formyl transferase, N-terminal, score 2e-87 637910012288 PS00373 Phosphoribosylglycinamide formyltransferase active site. 637910012289 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 637910012290 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 637910012291 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 637910012292 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 637910012293 domain interface [polypeptide binding]; other site 637910012294 active site 637910012295 catalytic site [active] 637910012296 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 637910012297 domain interface [polypeptide binding]; other site 637910012298 active site 637910012299 catalytic site [active] 637910012300 HMMPfam hit to PF02503, Polyphosphate kinase, score 0 637910012301 exopolyphosphatase; Provisional; Region: PRK10854 637910012302 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637910012303 nucleotide binding site [chemical binding]; other site 637910012304 HMMPfam hit to PF02541, Ppx/GppA phosphatase, score 1.2e-142 637910012305 MASE1; Region: MASE1; pfam05231 637910012306 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637910012307 diguanylate cyclase; Region: GGDEF; smart00267 637910012308 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637910012309 HMMPfam hit to PF00563, EAL, score 1.2e-101 637910012310 HMMPfam hit to PF05231, MASE1, score 2.8e-57 637910012311 8 transmembrane helices predicted for ROD24461 by TMHMM2.0 at aa 43-65, 80-102, 123-145, 165-187, 217-236, 240-259, 266-285 and 295-317 637910012312 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 637910012313 1 transmembrane helix predicted for ROD24471 by TMHMM2.0 at aa 20-42 637910012314 GMP synthase; Reviewed; Region: guaA; PRK00074 637910012315 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 637910012316 AMP/PPi binding site [chemical binding]; other site 637910012317 candidate oxyanion hole; other site 637910012318 catalytic triad [active] 637910012319 potential glutamine specificity residues [chemical binding]; other site 637910012320 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 637910012321 ATP Binding subdomain [chemical binding]; other site 637910012322 Ligand Binding sites [chemical binding]; other site 637910012323 Dimerization subdomain; other site 637910012324 HMMPfam hit to PF00958, GMP synthase, C-terminal, score 8.7e-60 637910012325 HMMPfam hit to PF03054, tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase, score 7.3e-10 637910012326 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 1.9e-52 637910012327 PS00442 Glutamine amidotransferases class-I active site. 637910012328 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 637910012329 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 637910012330 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 637910012331 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 637910012332 active site 637910012333 HMMPfam hit to PF00478, IMP dehydrogenase/GMP reductase, score 2.5e-243 637910012334 PS00487 IMP dehydrogenase / GMP reductase signature. 637910012335 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 3.9e-25 637910012336 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 637910012337 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 637910012338 generic binding surface II; other site 637910012339 generic binding surface I; other site 637910012340 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 5.8e-13 637910012341 HMMPfam hit to PF02601, Exonuclease VII, large subunit, score 2e-89 637910012342 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 637910012343 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 637910012344 active site 637910012345 Zn binding site [ion binding]; other site 637910012346 HMMPfam hit to PF01447, Peptidase M4, thermolysin, score 7e-19 637910012347 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 637910012348 HMMPfam hit to PF02868, Peptidase M4, thermolysin C-terminal, score 3.2e-32 637910012349 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 637910012350 HMMPfam hit to PF07191, Protein of unknown function DUF1407, score 3.8e-44 637910012351 GTP-binding protein Der; Reviewed; Region: PRK00093 637910012352 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 637910012353 G1 box; other site 637910012354 GTP/Mg2+ binding site [chemical binding]; other site 637910012355 Switch I region; other site 637910012356 G2 box; other site 637910012357 Switch II region; other site 637910012358 G3 box; other site 637910012359 G4 box; other site 637910012360 G5 box; other site 637910012361 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 637910012362 G1 box; other site 637910012363 GTP/Mg2+ binding site [chemical binding]; other site 637910012364 Switch I region; other site 637910012365 G2 box; other site 637910012366 G3 box; other site 637910012367 Switch II region; other site 637910012368 G4 box; other site 637910012369 G5 box; other site 637910012370 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 9.1e-45 637910012371 PS00017 ATP/GTP-binding site motif A (P-loop). 637910012372 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 1.6e-47 637910012373 PS00017 ATP/GTP-binding site motif A (P-loop). 637910012374 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 637910012375 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 637910012376 Trp docking motif [polypeptide binding]; other site 637910012377 active site 637910012378 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 9.4e-06 637910012379 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 9.1e-05 637910012380 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 0.00012 637910012381 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 2e-07 637910012382 HMMPfam hit to PF01011, Pyrrolo-quinoline quinone, score 4.2e-08 637910012383 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 637910012385 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 637910012386 1 transmembrane helix predicted for ROD24561 by TMHMM2.0 at aa 21-43 637910012387 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 637910012388 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 637910012389 dimer interface [polypeptide binding]; other site 637910012390 motif 1; other site 637910012391 active site 637910012392 motif 2; other site 637910012393 motif 3; other site 637910012394 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 637910012395 anticodon binding site; other site 637910012396 HMMPfam hit to PF03129, Anticodon-binding, score 9.2e-13 637910012397 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910012398 HMMPfam hit to PF00587, Aminoacyl-tRNA synthetase, class II (G, H, P and S), score 7.7e-56 637910012399 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 637910012400 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 637910012401 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 637910012402 HMMPfam hit to PF04551, IspG protein, score 1.4e-256 637910012403 cytoskeletal protein RodZ; Provisional; Region: PRK10856 637910012404 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637910012405 non-specific DNA binding site [nucleotide binding]; other site 637910012406 salt bridge; other site 637910012407 sequence-specific DNA binding site [nucleotide binding]; other site 637910012408 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 637910012409 1 transmembrane helix predicted for ROD24591 by TMHMM2.0 at aa 111-133 637910012410 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 3.4e-08 637910012411 Predicted helix-turn-helix motif with score 1707.000, SD 5.00 at aa 17-49, sequence VRLRNAREQLGLSQQAVAERLCLKVSTVRDIEE 637910012412 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 637910012413 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910012414 FeS/SAM binding site; other site 637910012415 HMMPfam hit to PF04055, Radical SAM, score 1.1e-18 637910012416 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 637910012417 active site 637910012418 multimer interface [polypeptide binding]; other site 637910012419 HMMPfam hit to PF00334, Nucleoside diphosphate kinase, core, score 8.8e-92 637910012420 PS00469 Nucleoside diphosphate kinases active site. 637910012421 pseudogene, truncated by frameshift mutation 637910012422 HMMPfam hit to PF06832, Penicillin-binding, C-terminal, score 1e-21 637910012423 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 7.3e-12 637910012424 HMMPfam hit to PF00912, Glycosyl transferase, family 51, score 2.1e-79 637910012425 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 637910012426 MG2 domain; Region: A2M_N; pfam01835 637910012427 Alpha-2-macroglobulin family; Region: A2M; pfam00207 637910012428 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 637910012429 surface patch; other site 637910012430 thioester region; other site 637910012431 HMMPfam hit to PF07703, Alpha-2-macroglobulin, N-terminal 2, score 3.4e-34 637910012432 PS00215 Mitochondrial energy transfer proteins signature. 637910012433 HMMPfam hit to PF01835, Alpha-2-macroglobulin, N-terminal, score 2.4e-83 637910012434 HMMPfam hit to PF03304, Mlp lipoprotein, score 0.00024 637910012435 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012436 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 637910012437 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 637910012438 active site residue [active] 637910012439 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 637910012440 active site residue [active] 637910012441 HMMPfam hit to PF00581, Rhodanese-like, score 1.2e-38 637910012442 PS00380 Rhodanese signature 1. 637910012443 HMMPfam hit to PF00581, Rhodanese-like, score 1.2e-27 637910012444 PS00683 Rhodanese C-terminal signature. 637910012445 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 637910012446 HMMPfam hit to PF07179, SseB, score 1.5e-201 637910012447 aminopeptidase B; Provisional; Region: PRK05015 637910012448 Peptidase; Region: DUF3663; pfam12404 637910012449 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 637910012450 interface (dimer of trimers) [polypeptide binding]; other site 637910012451 Substrate-binding/catalytic site; other site 637910012452 Zn-binding sites [ion binding]; other site 637910012453 HMMPfam hit to PF00883, Peptidase M17, leucyl aminopeptidase, C-terminal, score 6.1e-176 637910012454 PS00631 Cytosol aminopeptidase signature. 637910012455 hypothetical protein; Provisional; Region: PRK10721 637910012456 HMMPfam hit to PF04384, ISC system FeS cluster assembly, IscX, score 8.6e-45 637910012457 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 637910012458 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637910012459 catalytic loop [active] 637910012460 iron binding site [ion binding]; other site 637910012461 HMMPfam hit to PF00111, Ferredoxin, score 1.2e-22 637910012462 PS00814 Adrenodoxin family, iron-sulfur binding region signature. 637910012463 chaperone protein HscA; Provisional; Region: hscA; PRK05183 637910012464 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 637910012465 nucleotide binding site [chemical binding]; other site 637910012466 putative NEF/HSP70 interaction site [polypeptide binding]; other site 637910012467 SBD interface [polypeptide binding]; other site 637910012468 HMMPfam hit to PF00012, Heat shock protein 70, score 1.3e-282 637910012469 PS01036 Heat shock hsp70 proteins family signature 3. 637910012470 PS00329 Heat shock hsp70 proteins family signature 2. 637910012471 PS00297 Heat shock hsp70 proteins family signature 1. 637910012472 co-chaperone HscB; Provisional; Region: hscB; PRK05014 637910012473 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 637910012474 HSP70 interaction site [polypeptide binding]; other site 637910012475 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 637910012476 HMMPfam hit to PF07743, Heat shock cognate protein B, C-terminal oligomerisation, score 4.5e-33 637910012477 HMMPfam hit to PF00226, Heat shock protein DnaJ, N-terminal, score 1e-12 637910012478 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 637910012479 PS01152 Hypothetical hesB/yadR/yfhF family signature. 637910012480 HMMPfam hit to PF01521, HesB/YadR/YfhF, score 4.3e-44 637910012481 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 637910012482 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 637910012483 trimerization site [polypeptide binding]; other site 637910012484 active site 637910012485 HMMPfam hit to PF01592, NIF system FeS cluster assembly, NifU, N-terminal, score 5.5e-83 637910012486 cysteine desulfurase; Provisional; Region: PRK14012 637910012487 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 637910012488 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637910012489 catalytic residue [active] 637910012490 HMMPfam hit to PF00266, Aminotransferase, class V, score 7.1e-125 637910012491 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 637910012492 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 637910012493 Rrf2 family protein; Region: rrf2_super; TIGR00738 637910012494 HMMPfam hit to PF02082, Transcriptional regulator, Rrf2, score 2.9e-52 637910012495 PS01332 Uncharacterized protein family UPF0074 signature. 637910012496 Predicted helix-turn-helix motif with score 1222.000, SD 3.35 at aa 26-47, sequence VPLADISERQGISLSYLEQLFS 637910012497 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 637910012498 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 637910012499 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase, SpoU, score 1.5e-36 637910012500 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 637910012501 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 637910012502 active site 637910012503 dimerization interface [polypeptide binding]; other site 637910012504 HMMPfam hit to PF00459, Inositol monophosphatase, score 1.4e-114 637910012505 PS00629 Inositol monophosphatase family signature 1. 637910012506 PS00630 Inositol monophosphatase family signature 2. 637910012507 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 637910012508 HMMPfam hit to PF03824, Nickel/cobalt transporter high-affinity, score 7.7e-84 637910012509 7 transmembrane helices predicted for ROD24781 by TMHMM2.0 at aa 13-35, 68-90, 111-133, 148-170, 225-247, 251-273 and 294-316 637910012510 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 637910012511 HMMPfam hit to PF06226, Protein of unknown function DUF1007, score 2.5e-100 637910012512 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 637910012513 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 637910012514 ligand binding site [chemical binding]; other site 637910012515 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012516 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637910012517 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637910012518 Walker A/P-loop; other site 637910012519 ATP binding site [chemical binding]; other site 637910012520 Q-loop/lid; other site 637910012521 ABC transporter signature motif; other site 637910012522 Walker B; other site 637910012523 D-loop; other site 637910012524 H-loop/switch region; other site 637910012525 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637910012526 HMMPfam hit to PF00005, ABC transporter related, score 5.5e-48 637910012527 PS00017 ATP/GTP-binding site motif A (P-loop). 637910012528 HMMPfam hit to PF00005, ABC transporter related, score 5.8e-27 637910012529 PS00211 ABC transporters family signature. 637910012530 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637910012531 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637910012532 TM-ABC transporter signature motif; other site 637910012533 9 transmembrane helices predicted for ROD24831 by TMHMM2.0 at aa 15-32, 45-67, 87-109, 116-138, 170-192, 219-241, 245-267, 274-296 and 300-319 637910012534 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 4.6e-55 637910012535 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012536 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012537 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637910012538 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637910012539 TM-ABC transporter signature motif; other site 637910012540 10 transmembrane helices predicted for ROD24841 by TMHMM2.0 at aa 12-34, 39-61, 68-90, 95-117, 122-144, 164-186, 213-235, 245-262, 267-284 and 290-312 637910012541 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 4.1e-46 637910012542 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 637910012543 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 637910012544 N- and C-terminal domain interface [polypeptide binding]; other site 637910012545 active site 637910012546 MgATP binding site [chemical binding]; other site 637910012547 catalytic site [active] 637910012548 metal binding site [ion binding]; metal-binding site 637910012549 carbohydrate binding site [chemical binding]; other site 637910012550 putative homodimer interface [polypeptide binding]; other site 637910012551 HMMPfam hit to PF00370, Carbohydrate kinase, FGGY, score 3.8e-28 637910012552 HMMPfam hit to PF02782, Carbohydrate kinase, FGGY, score 1.2e-13 637910012553 PS00017 ATP/GTP-binding site motif A (P-loop). 637910012554 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 637910012555 putative active site [active] 637910012556 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 1.5e-19 637910012557 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 637910012558 PRD domain; Region: PRD; pfam00874 637910012559 PRD domain; Region: PRD; pfam00874 637910012560 HMMPfam hit to PF00874, PRD, score 6.6e-10 637910012561 HMMPfam hit to PF00874, PRD, score 1.4e-12 637910012562 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 637910012563 12 transmembrane helices predicted for ROD24881 by TMHMM2.0 at aa 9-31, 41-63, 70-89, 93-111, 132-154, 158-176, 207-229, 234-256, 269-288, 293-315, 328-350 and 354-371 637910012564 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.9e-19 637910012565 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 637910012566 active site 637910012567 catalytic residues [active] 637910012568 HMMPfam hit to PF01263, Aldose 1-epimerase, score 3.7e-16 637910012569 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 637910012570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910012571 putative substrate translocation pore; other site 637910012572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910012573 HMMPfam hit to PF00083, General substrate transporter score 1.7e-114 637910012574 12 transmembrane helices predicted for ROD24901 by TMHMM2.0 at aa 12-34, 54-76, 83-102, 107-129, 142-164, 184-206, 267-289, 304-326, 335-357, 362-384, 396-418 and 422-444 637910012575 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012576 PS00216 Sugar transport proteins signature 1. 637910012577 PS00217 Sugar transport proteins signature 2. 637910012578 PS00216 Sugar transport proteins signature 1. 637910012579 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012580 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012581 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637910012582 binding surface 637910012583 TPR motif; other site 637910012584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637910012585 binding surface 637910012586 TPR motif; other site 637910012587 TPR repeat; Region: TPR_11; pfam13414 637910012588 TPR repeat; Region: TPR_11; pfam13414 637910012589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637910012590 TPR motif; other site 637910012591 binding surface 637910012592 HMMPfam hit to PF00515, Tetratricopeptide TPR-1, score 0.019 637910012593 HMMPfam hit to PF00515, Tetratricopeptide TPR-1, score 0.0032 637910012594 HMMPfam hit to PF00515, Tetratricopeptide TPR-1, score 0.087 637910012595 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 637910012596 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637910012597 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637910012598 nucleotide binding site [chemical binding]; other site 637910012599 Predicted helix-turn-helix motif with score 1827.000, SD 5.41 at aa 29-50, sequence LSKSRLAQLTGLSIPAVSNILQ 637910012600 HMMPfam hit to PF00480, ROK, score 1e-15 637910012601 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 637910012602 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 637910012603 dimer interface [polypeptide binding]; other site 637910012604 active site 637910012605 glycine-pyridoxal phosphate binding site [chemical binding]; other site 637910012606 folate binding site [chemical binding]; other site 637910012607 HMMPfam hit to PF00464, Glycine hydroxymethyltransferase, score 2.5e-286 637910012608 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 637910012609 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 637910012610 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 637910012611 heme-binding site [chemical binding]; other site 637910012612 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 637910012613 FAD binding pocket [chemical binding]; other site 637910012614 FAD binding motif [chemical binding]; other site 637910012615 phosphate binding motif [ion binding]; other site 637910012616 beta-alpha-beta structure motif; other site 637910012617 NAD binding pocket [chemical binding]; other site 637910012618 Heme binding pocket [chemical binding]; other site 637910012619 HMMPfam hit to PF00042, Globin, subset, score 8.3e-28 637910012620 HMMPfam hit to PF00970, Oxidoreductase FAD-binding region, score 3.7e-12 637910012621 HMMPfam hit to PF00175, Oxidoreductase FAD/NAD(P)-binding, score 2.2e-18 637910012622 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637910012623 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637910012624 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637910012625 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 1.2e-17 637910012626 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.2e-27 637910012627 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 637910012628 Nitrogen regulatory protein P-II; Region: P-II; smart00938 637910012629 HMMPfam hit to PF00543, Nitrogen regulatory protein PII, score 1.7e-78 637910012630 PS00638 P-II protein C-terminal region signature. 637910012631 PS00496 P-II protein urydylation site. 637910012632 response regulator GlrR; Provisional; Region: PRK15115 637910012633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910012634 active site 637910012635 phosphorylation site [posttranslational modification] 637910012636 intermolecular recognition site; other site 637910012637 dimerization interface [polypeptide binding]; other site 637910012638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910012639 Walker A motif; other site 637910012640 ATP binding site [chemical binding]; other site 637910012641 Walker B motif; other site 637910012642 arginine finger; other site 637910012643 PS00688 Sigma-54 interaction domain C-terminal part signature. 637910012644 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 1.1e-149 637910012645 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 637910012646 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 637910012647 HMMPfam hit to PF00072, Response regulator receiver, score 1.4e-45 637910012648 hypothetical protein; Provisional; Region: PRK10722 637910012649 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637910012651 HAMP domain; Region: HAMP; pfam00672 637910012652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637910012653 dimer interface [polypeptide binding]; other site 637910012654 phosphorylation site [posttranslational modification] 637910012655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910012656 ATP binding site [chemical binding]; other site 637910012657 Mg2+ binding site [ion binding]; other site 637910012658 G-X-G motif; other site 637910012659 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2e-29 637910012660 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 8.1e-19 637910012661 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 5.5e-09 637910012662 2 transmembrane helices predicted for ROD24991 by TMHMM2.0 at aa 35-52 and 196-218 637910012663 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 637910012664 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 637910012665 dimerization interface [polypeptide binding]; other site 637910012666 ATP binding site [chemical binding]; other site 637910012667 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 637910012668 dimerization interface [polypeptide binding]; other site 637910012669 ATP binding site [chemical binding]; other site 637910012670 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 637910012671 putative active site [active] 637910012672 catalytic triad [active] 637910012673 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012674 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 2.2e-24 637910012675 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 2.6e-35 637910012676 HMMPfam hit to PF00586, AIR synthase related protein, score 2.4e-46 637910012677 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 637910012678 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637910012679 substrate binding pocket [chemical binding]; other site 637910012680 membrane-bound complex binding site; other site 637910012681 hinge residues; other site 637910012682 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637910012683 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637910012684 catalytic residue [active] 637910012685 1 transmembrane helix predicted for ROD25011 by TMHMM2.0 at aa 7-29 637910012686 HMMPfam hit to PF01464, Lytic transglycosylase-like, catalytic, score 1.1e-42 637910012687 PS00922 Prokaryotic transglycosylases signature. 637910012688 Helix-turn-helix domain; Region: HTH_18; pfam12833 637910012689 1 transmembrane helix predicted for ROD25021 by TMHMM2.0 at aa 10-29 637910012690 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012691 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 637910012692 nucleoside/Zn binding site; other site 637910012693 dimer interface [polypeptide binding]; other site 637910012694 catalytic motif [active] 637910012695 HMMPfam hit to PF00383, CMP/dCMP deaminase, zinc-binding, score 9.5e-47 637910012696 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 637910012697 hypothetical protein; Provisional; Region: PRK11590 637910012698 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 637910012699 1 transmembrane helix predicted for ROD25041 by TMHMM2.0 at aa 35-54 637910012700 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 637910012701 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637910012702 active site turn [active] 637910012703 phosphorylation site [posttranslational modification] 637910012704 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 637910012705 9 transmembrane helices predicted for ROD25051 by TMHMM2.0 at aa 116-138, 153-175, 182-204, 214-232, 288-310, 325-347, 360-382, 397-419 and 426-448 637910012706 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 5.2e-38 637910012707 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 2.4e-10 637910012708 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 637910012709 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 637910012710 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 637910012711 putative active site [active] 637910012712 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 2.5e-07 637910012713 PS01272 glucokinase regulatory protein family signature. 637910012714 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012715 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637910012716 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 637910012717 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 637910012718 putative active site [active] 637910012719 HMMPfam hit to PF01418, Helix-turn-helix protein RpiR, score 5.7e-51 637910012720 Predicted helix-turn-helix motif with score 1311.000, SD 3.65 at aa 35-56, sequence LSSQQLAEAAGVSQSSVVKFAQ 637910012721 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 1.2e-32 637910012722 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 637910012723 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 2e-05 637910012724 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910012725 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 637910012726 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase, score 2.1e-09 637910012727 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 637910012728 active site 637910012729 hydrophilic channel; other site 637910012730 dimerization interface [polypeptide binding]; other site 637910012731 catalytic residues [active] 637910012732 active site lid [active] 637910012733 HMMPfam hit to PF03740, Pyridoxal phosphate (active vitamin B6) biosynthesis PdxJ, score 2.2e-147 637910012734 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 637910012735 Recombination protein O N terminal; Region: RecO_N; pfam11967 637910012736 Recombination protein O C terminal; Region: RecO_C; pfam02565 637910012737 HMMPfam hit to PF02565, Recombination protein O, RecO, score 3.3e-113 637910012738 GTPase Era; Reviewed; Region: era; PRK00089 637910012739 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 637910012740 G1 box; other site 637910012741 GTP/Mg2+ binding site [chemical binding]; other site 637910012742 Switch I region; other site 637910012743 G2 box; other site 637910012744 Switch II region; other site 637910012745 G3 box; other site 637910012746 G4 box; other site 637910012747 G5 box; other site 637910012748 KH domain; Region: KH_2; pfam07650 637910012749 HMMPfam hit to PF07650, K Homology, type 2, score 1e-25 637910012750 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 2e-38 637910012751 PS00017 ATP/GTP-binding site motif A (P-loop). 637910012752 ribonuclease III; Reviewed; Region: rnc; PRK00102 637910012753 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 637910012754 dimerization interface [polypeptide binding]; other site 637910012755 active site 637910012756 metal binding site [ion binding]; metal-binding site 637910012757 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 637910012758 dsRNA binding site [nucleotide binding]; other site 637910012759 HMMPfam hit to PF00035, Double-stranded RNA binding, score 2.7e-17 637910012760 HMMPfam hit to PF00636, Ribonuclease III, score 1.7e-45 637910012761 PS00517 Ribonuclease III family signature. 637910012762 signal peptidase I; Provisional; Region: PRK10861 637910012763 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637910012764 Catalytic site [active] 637910012765 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 637910012766 PS00761 Signal peptidases I signature 3. 637910012767 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, C-terminal, score 1.5e-24 637910012768 PS00760 Signal peptidases I lysine active site. 637910012769 PS00501 Signal peptidases I serine active site. 637910012770 2 transmembrane helices predicted for ROD25141 by TMHMM2.0 at aa 5-27 and 60-82 637910012771 GTP-binding protein LepA; Provisional; Region: PRK05433 637910012772 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 637910012773 G1 box; other site 637910012774 putative GEF interaction site [polypeptide binding]; other site 637910012775 GTP/Mg2+ binding site [chemical binding]; other site 637910012776 Switch I region; other site 637910012777 G2 box; other site 637910012778 G3 box; other site 637910012779 Switch II region; other site 637910012780 G4 box; other site 637910012781 G5 box; other site 637910012782 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 637910012783 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 637910012784 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 637910012785 HMMPfam hit to PF06421, GTP-binding protein LepA, C-terminal, score 8.5e-79 637910012786 HMMPfam hit to PF00679, Translation elongation factor EFG/EF2, C-terminal, score 5.9e-32 637910012787 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 8.5e-12 637910012788 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 4.4e-74 637910012789 PS00301 GTP-binding elongation factors signature. 637910012790 PS00017 ATP/GTP-binding site motif A (P-loop). 637910012791 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 637910012792 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 637910012793 inhibitor site; inhibition site 637910012794 active site 637910012795 dimer interface [polypeptide binding]; other site 637910012796 catalytic residue [active] 637910012797 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase, score 3e-13 637910012798 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012799 SoxR reducing system protein RseC; Provisional; Region: PRK10862 637910012800 HMMPfam hit to PF04246, Positive regulator of sigma(E), RseC/MucC, score 5e-61 637910012801 2 transmembrane helices predicted for ROD25171 by TMHMM2.0 at aa 65-87 and 91-113 637910012802 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 637910012803 anti-sigma E factor; Provisional; Region: rseB; PRK09455 637910012804 HMMPfam hit to PF03888, MucB/RseB, score 1.4e-200 637910012805 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 637910012806 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 637910012807 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 637910012808 HMMPfam hit to PF03873, Anti sigma-E protein RseA, C-terminal, score 3.6e-28 637910012809 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012810 HMMPfam hit to PF03872, Anti sigma-E protein RseA, N-terminal, score 2.2e-52 637910012811 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 637910012812 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637910012813 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637910012814 DNA binding residues [nucleotide binding] 637910012815 HMMPfam hit to PF08281, RNA polymerase sigma factor 70, region 4 type 2, score 1.5e-21 637910012816 Predicted helix-turn-helix motif with score 1179.000, SD 3.20 at aa 154-175, sequence LSYEEIAAIMDCPVGTVRSRIF 637910012817 HMMPfam hit to PF04542, RNA polymerase sigma-70 region 2, score 2.7e-20 637910012818 PS01063 Sigma-70 factors ECF subfamily signature. 637910012819 L-aspartate oxidase; Provisional; Region: PRK09077 637910012820 L-aspartate oxidase; Provisional; Region: PRK06175 637910012821 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 637910012822 HMMPfam hit to PF00890, Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal, score 3.3e-140 637910012823 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydrogenase flavoprotein, C-terminal, score 1.1e-07 637910012824 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 637910012825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910012826 S-adenosylmethionine binding site [chemical binding]; other site 637910012827 HMMPfam hit to PF05175, Methyltransferase small, score 2.3e-05 637910012828 PS00092 N-6 Adenine-specific DNA methylases signature. 637910012829 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 637910012830 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 637910012831 ATP binding site [chemical binding]; other site 637910012832 Mg++ binding site [ion binding]; other site 637910012833 motif III; other site 637910012834 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637910012835 nucleotide binding region [chemical binding]; other site 637910012836 ATP-binding site [chemical binding]; other site 637910012837 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 2.9e-71 637910012838 PS00017 ATP/GTP-binding site motif A (P-loop). 637910012839 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 637910012840 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 1.2e-31 637910012841 PS00185 Isopenicillin N synthetase signature 1. 637910012842 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 637910012843 HMMPfam hit to PF01228, Formate C-acetyltransferase glycine radical, score 1.1e-51 637910012844 PS00850 Glycine radical signature. 637910012845 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 637910012846 ligand binding site [chemical binding]; other site 637910012847 active site 637910012848 UGI interface [polypeptide binding]; other site 637910012849 catalytic site [active] 637910012850 HMMPfam hit to PF03167, Uracil-DNA glycosylase superfamily, score 7.3e-85 637910012851 PS00130 Uracil-DNA glycosylase signature. 637910012852 putative methyltransferase; Provisional; Region: PRK10864 637910012853 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 637910012854 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 637910012855 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase, SpoU, score 6.7e-42 637910012856 HMMPfam hit to PF08032, RNA 2-O ribose methyltransferase, substrate-binding, score 1e-13 637910012857 PS00017 ATP/GTP-binding site motif A (P-loop). 637910012858 thioredoxin 2; Provisional; Region: PRK10996 637910012859 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 637910012860 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637910012861 catalytic residues [active] 637910012862 HMMPfam hit to PF00085, Thioredoxin domain, score 5.9e-39 637910012863 PS00194 Thioredoxin family active site. 637910012864 Uncharacterized conserved protein [Function unknown]; Region: COG3148 637910012865 HMMPfam hit to PF03942, DTW, score 7e-83 637910012866 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 637910012867 CoA binding domain; Region: CoA_binding_2; pfam13380 637910012868 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 637910012869 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 637910012870 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 637910012871 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 637910012872 HMMPfam hit to PF02629, CoA-binding, score 0.00097 637910012873 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.3e-15 637910012874 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 637910012875 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 637910012876 domain interface [polypeptide binding]; other site 637910012877 putative active site [active] 637910012878 catalytic site [active] 637910012879 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 637910012880 domain interface [polypeptide binding]; other site 637910012881 putative active site [active] 637910012882 catalytic site [active] 637910012883 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 1.6e-05 637910012884 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 9.3e-07 637910012885 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 637910012886 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910012887 HMMPfam hit to PF01609, Transposase, IS4-like, score 3.6e-29 637910012888 lipoprotein; Provisional; Region: PRK10759 637910012889 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012890 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 637910012891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910012892 putative substrate translocation pore; other site 637910012893 HMMPfam hit to PF00083, General substrate transporter score 1.6e-29 637910012894 12 transmembrane helices predicted for ROD25331 by TMHMM2.0 at aa 21-43, 62-84, 96-113, 118-140, 160-182, 197-214, 244-266, 281-303, 310-332, 337-359, 372-394 and 404-423 637910012895 PS00217 Sugar transport proteins signature 2. 637910012896 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012897 protein disaggregation chaperone; Provisional; Region: PRK10865 637910012898 Clp amino terminal domain; Region: Clp_N; pfam02861 637910012899 Clp amino terminal domain; Region: Clp_N; pfam02861 637910012900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910012901 Walker A motif; other site 637910012902 ATP binding site [chemical binding]; other site 637910012903 Walker B motif; other site 637910012904 arginine finger; other site 637910012905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910012906 Walker A motif; other site 637910012907 ATP binding site [chemical binding]; other site 637910012908 Walker B motif; other site 637910012909 arginine finger; other site 637910012910 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 637910012911 PS00017 ATP/GTP-binding site motif A (P-loop). 637910012912 HMMPfam hit to PF07724, ATPase AAA-2, score 1.5e-112 637910012913 PS00871 Chaperonins clpA/B signature 2. 637910012914 PS00017 ATP/GTP-binding site motif A (P-loop). 637910012915 PS00017 ATP/GTP-binding site motif A (P-loop). 637910012916 PS00870 Chaperonins clpA/B signature 1. 637910012917 HMMPfam hit to PF00004, AAA ATPase, core, score 4.2e-12 637910012918 PS00017 ATP/GTP-binding site motif A (P-loop). 637910012919 HMMPfam hit to PF02861, Clp, N-terminal, score 2.9e-14 637910012920 Predicted helix-turn-helix motif with score 1023.000, SD 2.67 at aa 120-141, sequence GTLADLLKSAGATTASISQAIE 637910012921 HMMPfam hit to PF02861, Clp, N-terminal, score 9.6e-17 637910012922 hypothetical protein; Provisional; Region: PRK10723 637910012923 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 637910012924 HMMPfam hit to PF02578, Protein of unknown function DUF152, score 2.3e-111 637910012925 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 637910012926 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637910012927 RNA binding surface [nucleotide binding]; other site 637910012928 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 637910012929 active site 637910012930 HMMPfam hit to PF00849, Pseudouridine synthase, score 7.1e-68 637910012931 PS01129 Rlu family of pseudouridine synthase signature. 637910012932 HMMPfam hit to PF01479, RNA-binding S4, score 1.6e-13 637910012933 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 637910012934 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 637910012935 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012936 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 637910012937 30S subunit binding site; other site 637910012938 HMMPfam hit to PF02482, Ribosomal protein S30Ae/sigma 54 modulation protein, score 7.2e-48 637910012939 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 637910012940 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 637910012941 Prephenate dehydratase; Region: PDT; pfam00800 637910012942 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 637910012943 putative L-Phe binding site [chemical binding]; other site 637910012944 HMMPfam hit to PF01817, Chorismate mutase, score 4.3e-30 637910012945 HMMPfam hit to PF00800, Prephenate dehydratase, score 2.2e-88 637910012946 PS00858 Prephenate dehydratase signature 2. 637910012947 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 637910012948 HMMPfam hit to PF08450, SMP-30/Gluconolaconase/LRE-like region, score 2.9e-103 637910012949 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 637910012950 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 2.5e-16 637910012951 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637910012952 catalytic loop [active] 637910012953 iron binding site [ion binding]; other site 637910012954 HMMPfam hit to PF00111, Ferredoxin, score 0.026 637910012955 1 transmembrane helix predicted for ROD25421 by TMHMM2.0 at aa 15-32 637910012956 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 637910012957 hydroxyglutarate oxidase; Provisional; Region: PRK11728 637910012958 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 637910012959 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 2.9e-74 637910012960 1 transmembrane helix predicted for ROD25431 by TMHMM2.0 at aa 7-24 637910012961 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910012962 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 637910012963 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 637910012964 HMMPfam hit to PF05544, Proline racemase, score 5.5e-124 637910012965 PAS fold; Region: PAS_4; pfam08448 637910012966 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637910012967 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910012968 HMMPfam hit to PF08448, PAS fold-4, score 5.2e-23 637910012969 PS00041 Bacterial regulatory proteins, araC family signature. 637910012970 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 1.6e-08 637910012971 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 637910012972 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 637910012973 inhibitor site; inhibition site 637910012974 active site 637910012975 dimer interface [polypeptide binding]; other site 637910012976 catalytic residue [active] 637910012977 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase, score 1.3e-48 637910012978 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 637910012979 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 637910012980 dimer interface [polypeptide binding]; other site 637910012981 NADP binding site [chemical binding]; other site 637910012982 catalytic residues [active] 637910012983 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 3.1e-16 637910012984 amino acid transporter; Region: 2A0306; TIGR00909 637910012985 HMMPfam hit to PF00324, Amino acid permease-associated region, score 1.1e-10 637910012986 13 transmembrane helices predicted for ROD25501 by TMHMM2.0 at aa 30-52, 57-79, 100-122, 142-164, 171-193, 213-235, 248-270, 293-315, 349-371, 376-398, 411-433, 437-454 and 475-497 637910012987 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 637910012988 Chorismate mutase type II; Region: CM_2; cl00693 637910012989 prephenate dehydrogenase; Validated; Region: PRK08507 637910012990 HMMPfam hit to PF02153, Prephenate dehydrogenase, score 2.5e-17 637910012991 HMMPfam hit to PF01817, Chorismate mutase, score 4.6e-32 637910012992 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 637910012993 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 637910012994 HMMPfam hit to PF00793, DAHP synthetase I/KDSA, score 1.2e-172 637910012995 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 637910012996 1 transmembrane helix predicted for ROD25531 by TMHMM2.0 at aa 7-29 637910012997 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 637910012998 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637910012999 metal binding site [ion binding]; metal-binding site 637910013000 active site 637910013001 I-site; other site 637910013002 2 transmembrane helices predicted for ROD25541 by TMHMM2.0 at aa 20-42 and 154-176 637910013003 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 0.0003 637910013004 HMMPfam hit to PF00990, GGDEF, score 8.9e-51 637910013005 putative outer membrane lipoprotein; Provisional; Region: PRK09967 637910013006 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637910013007 ligand binding site [chemical binding]; other site 637910013008 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013009 HMMPfam hit to PF00691, Outer membrane protein, OmpA/MotB, C-terminal, score 9.9e-41 637910013010 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 637910013011 HMMPfam hit to PF01245, Ribosomal protein L19, score 6.5e-84 637910013012 PS01015 Ribosomal protein L19 signature. 637910013013 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 637910013014 HMMPfam hit to PF01746, tRNA (guanine-N1-)-methyltransferase, score 2.4e-88 637910013015 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 637910013016 RimM N-terminal domain; Region: RimM; pfam01782 637910013017 PRC-barrel domain; Region: PRC; pfam05239 637910013018 HMMPfam hit to PF05239, PRC-barrel, score 2.3e-13 637910013019 HMMPfam hit to PF01782, RimM protein, score 6.8e-38 637910013020 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 637910013021 HMMPfam hit to PF00886, Ribosomal protein S16, score 2.9e-35 637910013022 PS00732 Ribosomal protein S16 signature. 637910013023 signal recognition particle protein; Provisional; Region: PRK10867 637910013024 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 637910013025 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 637910013026 P loop; other site 637910013027 GTP binding site [chemical binding]; other site 637910013028 Signal peptide binding domain; Region: SRP_SPB; pfam02978 637910013029 HMMPfam hit to PF02978, Signal recognition particle, SRP54 subunit, M-domain, score 9.4e-53 637910013030 HMMPfam hit to PF00448, Signal recognition particle, SRP54 subunit, GTPase, score 1.3e-119 637910013031 PS00300 SRP54-type proteins GTP-binding domain signature. 637910013032 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 637910013033 PS00017 ATP/GTP-binding site motif A (P-loop). 637910013034 HMMPfam hit to PF02881, Signal recognition particle, SRP54 subunit, helical bundle, score 2e-35 637910013035 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 637910013036 8 transmembrane helices predicted for ROD25611 by TMHMM2.0 at aa 2-24, 34-56, 63-85, 90-109, 129-151, 176-198, 210-227 and 237-254 637910013037 HMMPfam hit to PF01578, Cytochrome c assembly protein, score 5.4e-72 637910013038 hypothetical protein; Provisional; Region: PRK11573 637910013039 Domain of unknown function DUF21; Region: DUF21; pfam01595 637910013040 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637910013041 Transporter associated domain; Region: CorC_HlyC; smart01091 637910013042 HMMPfam hit to PF01595, Protein of unknown function DUF21, score 9.2e-59 637910013043 3 transmembrane helices predicted for ROD25621 by TMHMM2.0 at aa 32-54, 64-82 and 94-116 637910013044 Predicted helix-turn-helix motif with score 1130.000, SD 3.04 at aa 139-160, sequence LSKDELRTIVNESRSQISRRNQ 637910013045 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 2.1e-16 637910013046 HMMPfam hit to PF03471, Transporter-associated region, score 7.1e-24 637910013047 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 637910013048 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 637910013049 dimer interface [polypeptide binding]; other site 637910013050 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 637910013051 HMMPfam hit to PF01025, GrpE nucleotide exchange factor, score 9.6e-72 637910013052 PS01071 grpE protein signature. 637910013053 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 637910013054 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 637910013055 HMMPfam hit to PF01513, ATP-NAD/AcoX kinase, score 1.1e-106 637910013056 recombination and repair protein; Provisional; Region: PRK10869 637910013057 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 637910013058 Walker A/P-loop; other site 637910013059 ATP binding site [chemical binding]; other site 637910013060 Q-loop/lid; other site 637910013061 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 637910013062 Q-loop/lid; other site 637910013063 ABC transporter signature motif; other site 637910013064 Walker B; other site 637910013065 D-loop; other site 637910013066 H-loop/switch region; other site 637910013067 HMMPfam hit to PF02463, SMC protein, N-terminal, score 4e-10 637910013068 PS00017 ATP/GTP-binding site motif A (P-loop). 637910013069 Predicted helix-turn-helix motif with score 1303.000, SD 3.62 at aa 306-327, sequence SKQISLARKHHVSPEALPQYYQ 637910013070 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 637910013071 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 637910013072 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013073 HMMPfam hit to PF04355, SmpA/OmlA, score 5.9e-43 637910013074 PS00018 EF-hand calcium-binding domain. 637910013075 hypothetical protein; Validated; Region: PRK01777 637910013076 HMMPfam hit to PF03658, Protein of unknown function UPF0125, score 5.9e-55 637910013077 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 637910013078 putative coenzyme Q binding site [chemical binding]; other site 637910013079 PS00036 bZIP transcription factors basic domain signature. 637910013080 HMMPfam hit to PF03364, Streptomyces cyclase/dehydrase, score 5.8e-44 637910013081 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 637910013082 SmpB-tmRNA interface; other site 637910013083 HMMPfam hit to PF01668, SmpB protein, score 1.2e-40 637910013084 PS01317 Protein smpB signature. 637910013085 CR_GI6 637910013086 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 637910013087 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 637910013088 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 637910013089 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 637910013090 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 637910013091 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 637910013092 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 637910013093 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 637910013094 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 637910013095 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 637910013096 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 637910013097 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 637910013098 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 637910013099 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 637910013100 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 637910013101 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 637910013102 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 637910013103 HMMPfam hit to PF00801, PKD, score 6.3e-05 637910013104 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 637910013105 HMMPfam hit to PF02321, Outer membrane efflux protein, score 2.1e-22 637910013106 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.3e-11 637910013107 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637910013108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910013109 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 637910013110 Walker A/P-loop; other site 637910013111 ATP binding site [chemical binding]; other site 637910013112 Q-loop/lid; other site 637910013113 ABC transporter signature motif; other site 637910013114 Walker B; other site 637910013115 D-loop; other site 637910013116 H-loop/switch region; other site 637910013117 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 1.9e-06 637910013118 HMMPfam hit to PF00005, ABC transporter related, score 1.7e-54 637910013119 PS00017 ATP/GTP-binding site motif A (P-loop). 637910013120 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 637910013121 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637910013122 HlyD family secretion protein; Region: HlyD_3; pfam13437 637910013123 1 transmembrane helix predicted for ROD25731 by TMHMM2.0 at aa 13-35 637910013124 HMMPfam hit to PF00529, Secretion protein HlyD, score 9.4e-13 637910013125 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 637910013126 PS00543 HlyD family secretion proteins signature. 637910013127 prophage phiNP 637910013128 DinI-like family; Region: DinI; pfam06183 637910013129 HMMPfam hit to PF06183, DinI-like, score 7.3e-25 637910013130 YcfA-like protein; Region: YcfA; pfam07927 637910013131 HMMPfam hit to PF07927, YcfA-like, score 1.4e-20 637910013132 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 637910013133 HMMPfam hit to PF03681, Protein of unknown function UPF0150, score 4.8e-15 637910013134 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 637910013135 trimer interface [polypeptide binding]; other site 637910013136 active site 637910013137 substrate binding site [chemical binding]; other site 637910013138 CoA binding site [chemical binding]; other site 637910013139 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 72 637910013140 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 6.8 637910013141 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.14 637910013142 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 637910013143 HMMPfam hit to PF02413, Phage tail assembly chaperone gp38, score 4.5e-47 637910013144 Phage Tail Collar Domain; Region: Collar; pfam07484 637910013145 HMMPfam hit to PF03335, Phage tail fiber repeat, score 0.32 637910013146 HMMPfam hit to PF03335, Phage tail fiber repeat, score 0.16 637910013147 HMMPfam hit to PF03335, Phage tail fiber repeat, score 11 637910013148 HMMPfam hit to PF03335, Phage tail fiber repeat, score 0.77 637910013149 HMMPfam hit to PF07484, Phage Tail Collar, score 1.7e-21 637910013150 PS00213 Lipocalin signature. 637910013151 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 637910013152 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 637910013153 HMMPfam hit to PF04865, Phage baseplate assembly predicted J-like, score 1.4e-51 637910013154 Phage protein GP46; Region: GP46; pfam07409 637910013155 HMMPfam hit to PF07409, Phage GP46, score 5.8e-47 637910013156 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 637910013157 HMMPfam hit to PF06890, Bacteriophage Mu Gp45, score 1.4e-47 637910013158 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 637910013159 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 637910013160 HMMPfam hit to PF06893, Bacteriophage Mu P, score 8.5e-129 637910013161 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 637910013162 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 637910013163 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 637910013164 PS00044 Bacterial regulatory proteins, lysR family signature. 637910013165 HMMPfam hit to PF07157, DNA circulation, N-terminal, score 3.8e-36 637910013166 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 637910013167 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637910013168 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637910013169 catalytic residue [active] 637910013170 HMMPfam hit to PF01464, Lytic transglycosylase-like, catalytic, score 8.5e-31 637910013171 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 637910013172 Phage tail tube protein; Region: Tail_tube; pfam10618 637910013173 PS00017 ATP/GTP-binding site motif A (P-loop). 637910013174 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 637910013175 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 637910013176 HMMPfam hit to PF06274, Bacteriophage Mu tail sheath, score 6.1e-254 637910013177 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 637910013178 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 637910013179 HMMPfam hit to PF03864, Phage major capsid protein E, score 1.3e-08 637910013180 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 637910013181 PS00017 ATP/GTP-binding site motif A (P-loop). 637910013182 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 637910013183 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 637910013184 tandem repeat interface [polypeptide binding]; other site 637910013185 oligomer interface [polypeptide binding]; other site 637910013186 active site residues [active] 637910013187 HMMPfam hit to PF01343, Peptidase S49, score 4.5e-26 637910013188 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 637910013189 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 637910013190 HMMPfam hit to PF05136, Phage portal protein, lambda, score 8.8e-49 637910013191 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 637910013192 HMMPfam hit to PF02831, Head-to-tail joining protein W, gpW, score 4.2e-06 637910013193 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 637910013194 HMMPfam hit to PF05876, Phage terminase GpA, score 1.4e-180 637910013195 Predicted helix-turn-helix motif with score 2199.000, SD 6.68 at aa 1-22, sequence MNQSEFARLHGVSRKTVTQWKA 637910013196 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 637910013197 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 637910013198 virion protein; Provisional; Region: V; PHA02564 637910013199 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 637910013200 HMMPfam hit to PF05106, Holin, phage lambda, score 3.3e-08 637910013201 3 transmembrane helices predicted for ROD26101 by TMHMM2.0 at aa 15-37, 44-63 and 67-86 637910013202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910013203 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 637910013204 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 637910013205 DNA methylase; Region: N6_N4_Mtase; pfam01555 637910013206 HMMPfam hit to PF01555, DNA methylase N-4/N-6, score 1.8e-40 637910013207 PS00092 N-6 Adenine-specific DNA methylases signature. 637910013208 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 637910013209 putative DNA binding site [nucleotide binding]; other site 637910013210 putative Zn2+ binding site [ion binding]; other site 637910013211 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 637910013212 HMMPfam hit to PF06323, Phage antitermination Q, score 1.1e-24 637910013213 PS00237 G-protein coupled receptors signature. 637910013214 Protein of unknown function (DUF968); Region: DUF968; pfam06147 637910013215 HMMPfam hit to PF06914, Protein of unknown function DUF1277, score 4.7e-143 637910013216 PS00190 Cytochrome c family heme-binding site signature. 637910013217 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 637910013218 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 637910013219 cofactor binding site; other site 637910013220 DNA binding site [nucleotide binding] 637910013221 substrate interaction site [chemical binding]; other site 637910013222 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 637910013223 HMMPfam hit to PF00145, C-5 cytosine-specific DNA methylase, score 5.7e-07 637910013224 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 637910013225 PS00228 Tubulin-beta mRNA autoregulation signal. 637910013226 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 637910013227 HMMPfam hit to PF05869, DNA N-6-adenine-methyltransferase, score 6.6e-76 637910013228 PS00092 N-6 Adenine-specific DNA methylases signature. 637910013229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910013230 DNA-binding site [nucleotide binding]; DNA binding site 637910013231 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 637910013232 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 5.6e-05 637910013233 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 637910013234 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 637910013235 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 637910013236 Predicted helix-turn-helix motif with score 1294.000, SD 3.59 at aa 29-50, sequence GGYAEAAEWLDVTENSLFNRLR 637910013237 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637910013238 non-specific DNA binding site [nucleotide binding]; other site 637910013239 salt bridge; other site 637910013240 sequence-specific DNA binding site [nucleotide binding]; other site 637910013241 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 7.3e-13 637910013242 Predicted helix-turn-helix motif with score 1443.000, SD 4.10 at aa 14-35, sequence LTLSYVANLVGIDPANLSRIER 637910013243 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637910013244 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637910013245 non-specific DNA binding site [nucleotide binding]; other site 637910013246 salt bridge; other site 637910013247 sequence-specific DNA binding site [nucleotide binding]; other site 637910013248 Predicted transcriptional regulator [Transcription]; Region: COG2932 637910013249 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 637910013250 Catalytic site [active] 637910013251 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 4.8e-13 637910013252 Predicted helix-turn-helix motif with score 1316.000, SD 3.67 at aa 16-37, sequence MKISDLADAVGIDGANVSRVET 637910013253 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, C-terminal, score 4.6e-18 637910013254 1 transmembrane helix predicted for ROD26223 by TMHMM2.0 at aa 13-35 637910013255 Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065 637910013256 HD domain; Region: HD_3; cl17350 637910013257 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 637910013258 DNA methylase; Region: N6_N4_Mtase; pfam01555 637910013259 HMMPfam hit to PF01555, DNA methylase N-4/N-6, score 1.8e-22 637910013260 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013261 PS00017 ATP/GTP-binding site motif A (P-loop). 637910013262 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 637910013263 active site 637910013264 catalytic site [active] 637910013265 substrate binding site [chemical binding]; other site 637910013266 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 637910013267 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637910013268 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 637910013269 Int/Topo IB signature motif; other site 637910013270 PS00017 ATP/GTP-binding site motif A (P-loop). 637910013271 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 1.3e-13 637910013272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910013273 AAA domain; Region: AAA_21; pfam13304 637910013274 Walker A/P-loop; other site 637910013275 ATP binding site [chemical binding]; other site 637910013276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 637910013277 Walker B; other site 637910013278 D-loop; other site 637910013279 H-loop/switch region; other site 637910013280 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 637910013281 HMMPfam hit to PF02086, D12 class N6 adenine-specific DNA methyltransferase, score 3.4e-06 637910013282 pseudogene, C-terminus missing, truncated by ISEc14 insertion; Part of the backbone found conserved in EC K12 and therefore not associated with prophage NP or the IS elements which have inserted on either side of this gene. 637910013283 CR_GI7 637910013284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910013285 Transposase; Region: HTH_Tnp_1; pfam01527 637910013286 HMMPfam hit to PF01527, Transposase IS3/IS911, score 5.2e-23 637910013287 Predicted helix-turn-helix motif with score 1681.000, SD 4.91 at aa 23-44, sequence YSVAEVSDRLGVSAHSLYKWLR 637910013288 putative transposase OrfB; Reviewed; Region: PHA02517 637910013289 HTH-like domain; Region: HTH_21; pfam13276 637910013290 Integrase core domain; Region: rve; pfam00665 637910013291 Integrase core domain; Region: rve_3; pfam13683 637910013292 HMMPfam hit to PF00665, Integrase, catalytic core, score 1.3e-45 637910013293 PS00501 Signal peptidases I serine active site. 637910013294 Integrase core domain; Region: rve; pfam00665 637910013295 Integrase core domain; Region: rve_3; pfam13683 637910013296 HMMPfam hit to PF00665, Integrase, catalytic core, score 7.1e-35 637910013297 pseudogene, C-terminus deleted by another IS3 family IS element 637910013298 HMMPfam hit to PF01527, Transposase IS3/IS911, score 1.8e-23 637910013299 Predicted helix-turn-helix motif with score 1325.000, SD 3.70 at aa 25-46, sequence HSVSSVATRLDITTHSLYAWIK 637910013300 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 637910013301 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 637910013302 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 637910013303 cysteine protease domain, YopT-type; Region: yopT_cys_prot; TIGR01586 637910013304 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 637910013305 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 637910013306 HMMPfam hit to PF04488, Glycosyltransferase sugar-binding region containing DXD motif, score 1.6e-28 637910013307 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 637910013308 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910013309 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910013310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910013311 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910013312 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910013313 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910013314 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910013315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910013316 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910013317 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910013318 Transposase; Region: HTH_Tnp_1; pfam01527 637910013319 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910013320 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910013321 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910013322 Transposase; Region: HTH_Tnp_1; pfam01527 637910013323 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910013324 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910013325 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910013326 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910013327 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910013328 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910013329 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910013330 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910013331 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910013332 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910013333 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910013334 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910013335 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910013336 pseudogene, C-terminus deleted by ISCro1 insertion, N-terminal part fragmented by frameshift mutation and premature stop codon; Repeated at 2986669..2983023 637910013337 HMMPfam hit to PF03527, RHS protein, score 8.6e-23 637910013338 HMMPfam hit to PF05593, YD repeat, score 0.047 637910013339 HMMPfam hit to PF05593, YD repeat, score 0.0065 637910013340 HMMPfam hit to PF05593, YD repeat, score 0.00029 637910013341 HMMPfam hit to PF05593, YD repeat, score 0.19 637910013342 HMMPfam hit to PF05593, YD repeat, score 9.3e-07 637910013343 HMMPfam hit to PF05593, YD repeat, score 0.00021 637910013344 HMMPfam hit to PF05593, YD repeat, score 0.0029 637910013345 HMMPfam hit to PF05593, YD repeat, score 0.00044 637910013346 HMMPfam hit to PF05593, YD repeat, score 0.0037 637910013347 HMMPfam hit to PF05593, YD repeat, score 0.014 637910013348 HMMPfam hit to PF05593, YD repeat, score 3.6 637910013349 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 637910013350 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 637910013351 active site 637910013352 catalytic site [active] 637910013353 metal binding site [ion binding]; metal-binding site 637910013354 HMMPfam hit to PF03009, Glycerophosphoryl diester phosphodiesterase, score 5.7e-107 637910013355 PS00017 ATP/GTP-binding site motif A (P-loop). 637910013356 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 637910013357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910013358 putative substrate translocation pore; other site 637910013359 12 transmembrane helices predicted for ROD26521 by TMHMM2.0 at aa 28-45, 65-87, 94-116, 120-142, 161-183, 188-207, 254-273, 293-312, 319-341, 351-373, 386-408 and 418-437 637910013360 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.2e-48 637910013361 PS00942 glpT family of transporters signature. 637910013362 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 637910013363 hydroxyglutarate oxidase; Provisional; Region: PRK11728 637910013364 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 637910013365 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 1.5e-70 637910013366 PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1. 637910013367 PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. 637910013368 HMMPfam hit to PF04324, BFD-like [2Fe-2S]-binding region, score 1.7e-18 637910013369 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 637910013370 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 637910013371 HMMPfam hit to PF00890, Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal, score 1.6e-89 637910013372 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 637910013373 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637910013374 Cysteine-rich domain; Region: CCG; pfam02754 637910013375 Cysteine-rich domain; Region: CCG; pfam02754 637910013376 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910013377 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0022 637910013378 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910013379 HMMPfam hit to PF02754, Cysteine-rich region, CCG, score 1e-08 637910013380 HMMPfam hit to PF02754, Cysteine-rich region, CCG, score 6e-17 637910013381 hypothetical protein; Provisional; Region: PRK09956 637910013382 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 637910013383 HMMPfam hit to PF04754, Transposase (), YhgA-like, score 1.8e-198 637910013384 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 637910013385 HMMPfam hit to PF03328, HpcH/HpaI aldolase, score 4.5e-113 637910013386 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 637910013387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910013388 putative substrate translocation pore; other site 637910013389 12 transmembrane helices predicted for ROD26591 by TMHMM2.0 at aa 13-30, 52-74, 79-101, 107-129, 142-164, 174-196, 241-263, 273-295, 308-325, 329-351, 358-380 and 395-417 637910013390 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.8e-47 637910013391 L-rhamnonate dehydratase; Provisional; Region: PRK15440 637910013392 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 637910013393 putative active site pocket [active] 637910013394 putative metal binding site [ion binding]; other site 637910013395 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 1.1e-27 637910013396 HMMPfam hit to PF02746, Mandelate racemase/muconate lactonizing enzyme, N-terminal, score 0.00029 637910013397 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 637910013398 Transcriptional regulator [Transcription]; Region: IclR; COG1414 637910013399 Bacterial transcriptional regulator; Region: IclR; pfam01614 637910013400 HMMPfam hit to PF01614, Transcriptional regulator IclR, C-terminal, score 7.1e-52 637910013401 PS01051 Bacterial regulatory proteins, iclR family signature. 637910013402 HMMPfam hit to PF09339, Transcriptional regulator IclR, N-terminal, score 7e-16 637910013403 hypothetical protein; Provisional; Region: PRK03673 637910013404 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 637910013405 putative MPT binding site; other site 637910013406 Competence-damaged protein; Region: CinA; cl00666 637910013407 HMMPfam hit to PF00994, Molybdopterin binding, score 2.9e-50 637910013408 YfaZ precursor; Region: YfaZ; pfam07437 637910013409 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 637910013410 HMMPfam hit to PF07437, YfaZ, score 3.6e-115 637910013411 1 transmembrane helix predicted for ROD26641 by TMHMM2.0 at aa 41-63 637910013412 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 637910013413 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 6.7e-24 637910013414 PS00893 mutT domain signature. 637910013415 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 637910013416 catalytic core [active] 637910013417 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 2.3e-09 637910013418 1 transmembrane helix predicted for ROD26661 by TMHMM2.0 at aa 30-52 637910013419 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013420 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 637910013421 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 637910013422 putative AMP binding site [chemical binding]; other site 637910013423 putative active site [active] 637910013424 acyl-activating enzyme (AAE) consensus motif; other site 637910013425 putative CoA binding site [chemical binding]; other site 637910013426 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 2e-58 637910013427 PS00455 AMP-binding domain signature. 637910013428 O-succinylbenzoate synthase; Provisional; Region: PRK05105 637910013429 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 637910013430 active site 637910013431 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 4.1e-10 637910013432 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 637910013433 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 637910013434 substrate binding site [chemical binding]; other site 637910013435 oxyanion hole (OAH) forming residues; other site 637910013436 trimer interface [polypeptide binding]; other site 637910013437 HMMPfam hit to PF00378, Crotonase, core, score 1.5e-73 637910013438 PS00166 Enoyl-CoA hydratase/isomerase signature. 637910013439 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 637910013440 HMMPfam hit to PF00561, Alpha/beta hydrolase fold-1, score 1.6e-11 637910013441 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 637910013442 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 637910013443 dimer interface [polypeptide binding]; other site 637910013444 tetramer interface [polypeptide binding]; other site 637910013445 PYR/PP interface [polypeptide binding]; other site 637910013446 TPP binding site [chemical binding]; other site 637910013447 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 637910013448 TPP-binding site; other site 637910013449 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 637910013450 isochorismate synthases; Region: isochor_syn; TIGR00543 637910013451 HMMPfam hit to PF00425, Chorismate binding, C-terminal, score 4.6e-18 637910013452 hypothetical protein; Provisional; Region: PRK10404 637910013453 HMMPfam hit to PF05957, Protein of unknown function DUF883, ElaB, score 8.1e-49 637910013454 1 transmembrane helix predicted for ROD26731 by TMHMM2.0 at aa 80-99 637910013455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637910013456 Coenzyme A binding pocket [chemical binding]; other site 637910013457 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 4.6e-12 637910013458 pseudogene, truncated by premature stop codon 637910013459 HMMPfam hit to PF00753, beta-lactamase-like, score 4.4e-09 637910013460 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 637910013461 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 637910013462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910013463 active site 637910013464 phosphorylation site [posttranslational modification] 637910013465 intermolecular recognition site; other site 637910013466 dimerization interface [polypeptide binding]; other site 637910013467 HMMPfam hit to PF01584, CheW-like protein, score 1.8e-27 637910013468 HMMPfam hit to PF00072, Response regulator receiver, score 2.8e-07 637910013469 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 637910013470 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910013471 HMMPfam hit to PF01609, Transposase, IS4-like, score 3.6e-20 637910013472 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 637910013473 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 637910013474 14 transmembrane helices predicted for ROD26781 by TMHMM2.0 at aa 6-28, 35-57, 72-94, 106-120, 125-147, 159-181, 201-223, 236-258, 268-290, 297-319, 329-351, 371-393, 408-430 and 450-472 637910013475 HMMPfam hit to PF00361, NADH/Ubiquinone/plastoquinone (complex I), score 1.7e-94 637910013476 PS00017 ATP/GTP-binding site motif A (P-loop). 637910013477 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 637910013478 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 637910013479 14 transmembrane helices predicted for ROD26791 by TMHMM2.0 at aa 4-18, 30-49, 81-103, 115-134, 139-161, 174-196, 222-244, 251-273, 288-307, 314-336, 341-363, 384-406, 416-438 and 459-481 637910013480 HMMPfam hit to PF00361, NADH/Ubiquinone/plastoquinone (complex I), score 3.2e-74 637910013481 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 637910013482 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 637910013483 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 637910013484 16 transmembrane helices predicted for ROD26801 by TMHMM2.0 at aa 4-21, 28-50, 84-106, 113-132, 136-158, 171-193, 213-235, 248-267, 277-299, 306-328, 332-354, 375-397, 412-434, 455-477, 492-514 and 590-612 637910013485 HMMPfam hit to PF00361, NADH/Ubiquinone/plastoquinone (complex I), score 1.5e-121 637910013486 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013487 HMMPfam hit to PF00662, NADH-Ubiquinone oxidoreductase (complex I), chain 5/L, N-terminal, score 5.7e-30 637910013488 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 637910013489 HMMPfam hit to PF00420, NADH-ubiquinone oxidoreductase, chain 4L, score 7.1e-32 637910013490 3 transmembrane helices predicted for ROD26811 by TMHMM2.0 at aa 4-23, 28-50 and 60-82 637910013491 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 637910013492 HMMPfam hit to PF00499, NADH-ubiquinone/plastoquinone oxidoreductase, chain 6, score 1.5e-31 637910013493 5 transmembrane helices predicted for ROD26821 by TMHMM2.0 at aa 4-22, 29-51, 56-78, 91-113 and 133-155 637910013494 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 637910013495 4Fe-4S binding domain; Region: Fer4; pfam00037 637910013496 4Fe-4S binding domain; Region: Fer4; pfam00037 637910013497 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 2.8e-08 637910013498 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910013499 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.00012 637910013500 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910013501 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 637910013502 8 transmembrane helices predicted for ROD26841 by TMHMM2.0 at aa 13-35, 81-103, 113-135, 155-174, 189-206, 235-257, 267-289 and 302-324 637910013503 HMMPfam hit to PF00146, Respiratory-chain NADH dehydrogenase, subunit 1, score 1e-183 637910013504 PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 637910013505 PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. 637910013506 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 637910013507 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 637910013508 catalytic loop [active] 637910013509 iron binding site [ion binding]; other site 637910013510 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 637910013511 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 637910013512 [4Fe-4S] binding site [ion binding]; other site 637910013513 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 637910013514 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 4.4e-06 637910013515 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 4.4e-15 637910013516 PS00643 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. 637910013517 PS00642 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. 637910013518 HMMPfam hit to PF00111, Ferredoxin, score 1.2e-13 637910013519 PS00641 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. 637910013520 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013521 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 637910013522 SLBB domain; Region: SLBB; pfam10531 637910013523 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 637910013524 PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. 637910013525 HMMPfam hit to PF01512, Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit, score 7.7e-183 637910013526 PS00644 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. 637910013527 NADH dehydrogenase subunit E; Validated; Region: PRK07539 637910013528 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 637910013529 putative dimer interface [polypeptide binding]; other site 637910013530 [2Fe-2S] cluster binding site [ion binding]; other site 637910013531 HMMPfam hit to PF01257, NADH dehydrogenase (ubiquinone), 24 kDa subunit, score 4e-103 637910013532 PS01099 Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. 637910013533 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 637910013534 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 637910013535 NADH dehydrogenase subunit D; Validated; Region: PRK06075 637910013536 HMMPfam hit to PF00346, NADH-ubiquinone oxidoreductase, chain 49kDa, score 4.6e-216 637910013537 PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 637910013538 HMMPfam hit to PF00329, NADH dehydrogenase (ubiquinone), 30 kDa subunit, score 1.2e-37 637910013539 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 637910013540 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 kDa subunit, score 1.5e-56 637910013541 PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. 637910013542 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013543 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 637910013544 HMMPfam hit to PF00507, NADH-ubiquinone/plastoquinone oxidoreductase, chain 3, score 5.1e-39 637910013545 3 transmembrane helices predicted for ROD26901 by TMHMM2.0 at aa 15-37, 66-88 and 98-120 637910013546 PS00012 Phosphopantetheine attachment site. 637910013547 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 637910013548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910013549 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 637910013550 putative dimerization interface [polypeptide binding]; other site 637910013551 HMMPfam hit to PF03466, LysR, substrate-binding, score 3.7e-27 637910013552 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 637910013553 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2.8e-16 637910013554 PS00044 Bacterial regulatory proteins, lysR family signature. 637910013555 Predicted helix-turn-helix motif with score 1312.000, SD 3.66 at aa 26-47, sequence NTFAAAAAAVCRTQSAVSQQMQ 637910013556 aminotransferase AlaT; Validated; Region: PRK09265 637910013557 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637910013558 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910013559 homodimer interface [polypeptide binding]; other site 637910013560 catalytic residue [active] 637910013561 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 4.1e-38 637910013562 5'-nucleotidase; Provisional; Region: PRK03826 637910013563 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 5.7e-16 637910013564 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 637910013565 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 637910013566 TrkA-C domain; Region: TrkA_C; pfam02080 637910013567 TrkA-C domain; Region: TrkA_C; pfam02080 637910013568 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 637910013569 11 transmembrane helices predicted for ROD26941 by TMHMM2.0 at aa 5-22, 29-51, 61-83, 96-118, 138-160, 173-195, 429-451, 464-482, 502-524, 544-566 and 586-608 637910013570 PS01271 Sodium:sulfate symporter family signature. 637910013571 HMMPfam hit to PF03600, Divalent ion symporter, score 1.3e-52 637910013572 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013573 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013574 HMMPfam hit to PF02080, TrkA-C, score 4.4e-12 637910013575 HMMPfam hit to PF02080, TrkA-C, score 7.6e-12 637910013576 putative phosphatase; Provisional; Region: PRK11587 637910013577 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910013578 motif II; other site 637910013579 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 6e-40 637910013580 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013581 hypothetical protein; Validated; Region: PRK05445 637910013582 HMMPfam hit to PF03887, YfbU, score 3.7e-118 637910013583 hypothetical protein; Provisional; Region: PRK01816 637910013584 HMMPfam hit to PF04217, Protein of unknown function DUF412, score 2.6e-109 637910013585 2 transmembrane helices predicted for ROD26971 by TMHMM2.0 at aa 46-65 and 69-91 637910013586 propionate/acetate kinase; Provisional; Region: PRK12379 637910013587 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 637910013588 HMMPfam hit to PF00871, Acetate and butyrate kinase, score 9.9e-257 637910013589 PS01075 Acetate and butyrate kinases family signature 1. 637910013590 PS01076 Acetate and butyrate kinases family signature 2. 637910013591 phosphate acetyltransferase; Reviewed; Region: PRK05632 637910013592 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 637910013593 DRTGG domain; Region: DRTGG; pfam07085 637910013594 phosphate acetyltransferase; Region: pta; TIGR00651 637910013595 HMMPfam hit to PF07085, DRTGG, score 3.6e-58 637910013596 HMMPfam hit to PF01515, Phosphate acetyl/butaryl transferase, score 1.9e-190 637910013597 hypothetical protein; Provisional; Region: PRK11588 637910013598 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 637910013599 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 1.2e-192 637910013600 13 transmembrane helices predicted for ROD27001 by TMHMM2.0 at aa 21-43, 108-129, 150-167, 177-199, 206-228, 232-254, 289-311, 316-338, 351-373, 383-405, 412-434, 454-473 and 485-507 637910013601 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 637910013602 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637910013603 PYR/PP interface [polypeptide binding]; other site 637910013604 dimer interface [polypeptide binding]; other site 637910013605 TPP binding site [chemical binding]; other site 637910013606 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637910013607 HMMPfam hit to PF02780, Transketolase, C-terminal, score 3.9e-38 637910013608 HMMPfam hit to PF02779, Transketolase, central region, score 1.6e-15 637910013609 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637910013610 TPP-binding site [chemical binding]; other site 637910013611 dimer interface [polypeptide binding]; other site 637910013612 HMMPfam hit to PF00456, Transketolase, N-terminal, score 6.3e-37 637910013613 PS00107 Protein kinases ATP-binding region signature. 637910013614 1 transmembrane helix predicted for ROD27021 by TMHMM2.0 at aa 21-43 637910013615 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 637910013616 11 transmembrane helices predicted for ROD27031 by TMHMM2.0 at aa 10-32, 39-61, 95-114, 121-143, 147-169, 226-243, 258-280, 310-332, 342-364, 377-399 and 423-445 637910013617 HMMPfam hit to PF04215, sugar-specific permease, SgaT/UlaA, score 1.7e-129 637910013618 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 637910013619 active site 637910013620 P-loop; other site 637910013621 phosphorylation site [posttranslational modification] 637910013622 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 4.9e-19 637910013623 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637910013624 active site 637910013625 phosphorylation site [posttranslational modification] 637910013626 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 8.3e-36 637910013627 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 637910013628 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910013629 DNA binding site [nucleotide binding] 637910013630 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 637910013631 putative dimerization interface [polypeptide binding]; other site 637910013632 putative ligand binding site [chemical binding]; other site 637910013633 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 5.7e-10 637910013634 Predicted helix-turn-helix motif with score 2022.000, SD 6.07 at aa 13-34, sequence VTIADVAQLAGVGTMTVSRALR 637910013635 PS00356 Bacterial regulatory proteins, lacI family signature. 637910013636 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 2.3e-07 637910013637 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 637910013638 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 637910013639 nudix motif; other site 637910013640 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 3e-26 637910013641 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 637910013642 active site 637910013643 metal binding site [ion binding]; metal-binding site 637910013644 homotetramer interface [polypeptide binding]; other site 637910013645 HMMPfam hit to PF00149, Metallophosphoesterase, score 1.9e-15 637910013646 glutathione S-transferase; Provisional; Region: PRK15113 637910013647 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 637910013648 C-terminal domain interface [polypeptide binding]; other site 637910013649 GSH binding site (G-site) [chemical binding]; other site 637910013650 dimer interface [polypeptide binding]; other site 637910013651 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 637910013652 N-terminal domain interface [polypeptide binding]; other site 637910013653 putative dimer interface [polypeptide binding]; other site 637910013654 putative substrate binding pocket (H-site) [chemical binding]; other site 637910013655 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 5.1e-13 637910013656 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 637910013657 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 637910013658 C-terminal domain interface [polypeptide binding]; other site 637910013659 GSH binding site (G-site) [chemical binding]; other site 637910013660 dimer interface [polypeptide binding]; other site 637910013661 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 637910013662 N-terminal domain interface [polypeptide binding]; other site 637910013663 putative dimer interface [polypeptide binding]; other site 637910013664 active site 637910013665 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 5.8e-08 637910013666 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 1.8e-10 637910013667 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 637910013668 homooctamer interface [polypeptide binding]; other site 637910013669 active site 637910013670 HMMPfam hit to PF02152, Dihydroneopterin aldolase, score 4.8e-45 637910013671 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 637910013672 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 637910013673 putative NAD(P) binding site [chemical binding]; other site 637910013674 putative active site [active] 637910013675 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 5.7e-20 637910013676 HMMPfam hit to PF08338, Region of unknown function DUF1731, score 1.6e-23 637910013677 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 637910013678 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 637910013679 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 4.1e-10 637910013680 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 637910013681 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637910013682 Walker A/P-loop; other site 637910013683 ATP binding site [chemical binding]; other site 637910013684 Q-loop/lid; other site 637910013685 ABC transporter signature motif; other site 637910013686 Walker B; other site 637910013687 D-loop; other site 637910013688 H-loop/switch region; other site 637910013689 HMMPfam hit to PF00005, ABC transporter related, score 1.6e-63 637910013690 PS00211 ABC transporters family signature. 637910013691 PS00527 Ribosomal protein S14 signature. 637910013692 PS00017 ATP/GTP-binding site motif A (P-loop). 637910013693 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637910013694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910013695 dimer interface [polypeptide binding]; other site 637910013696 conserved gate region; other site 637910013697 putative PBP binding loops; other site 637910013698 ABC-ATPase subunit interface; other site 637910013699 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.3e-17 637910013700 4 transmembrane helices predicted for ROD27151 by TMHMM2.0 at aa 25-47, 57-79, 167-189 and 199-221 637910013701 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910013702 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637910013703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910013704 dimer interface [polypeptide binding]; other site 637910013705 conserved gate region; other site 637910013706 putative PBP binding loops; other site 637910013707 ABC-ATPase subunit interface; other site 637910013708 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.8e-35 637910013709 5 transmembrane helices predicted for ROD27161 by TMHMM2.0 at aa 15-37, 58-80, 90-108, 149-171 and 191-213 637910013710 PS00017 ATP/GTP-binding site motif A (P-loop). 637910013711 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910013712 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 637910013713 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637910013714 substrate binding pocket [chemical binding]; other site 637910013715 membrane-bound complex binding site; other site 637910013716 hinge residues; other site 637910013717 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 1.3e-98 637910013718 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 637910013719 1 transmembrane helix predicted for ROD27171 by TMHMM2.0 at aa 5-24 637910013720 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 637910013721 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637910013722 substrate binding pocket [chemical binding]; other site 637910013723 membrane-bound complex binding site; other site 637910013724 hinge residues; other site 637910013725 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 5.4e-90 637910013726 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 637910013727 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 637910013728 Flavoprotein; Region: Flavoprotein; pfam02441 637910013729 HMMPfam hit to PF02441, Flavoprotein, score 1.6e-50 637910013730 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637910013731 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910013732 DNA binding site [nucleotide binding] 637910013733 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 637910013734 ligand binding site [chemical binding]; other site 637910013735 dimerization interface [polypeptide binding]; other site 637910013736 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 8.2e-25 637910013737 HMMPfam hit to PF08212, Lipocalin-like, score 0.00038 637910013738 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 2.9e-07 637910013739 Predicted helix-turn-helix motif with score 1656.000, SD 4.83 at aa 5-26, sequence IRIKDIASASGVSLAAVSRALK 637910013740 PS00356 Bacterial regulatory proteins, lacI family signature. 637910013741 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 637910013742 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 637910013743 11 transmembrane helices predicted for ROD27211 by TMHMM2.0 at aa 46-68, 95-114, 129-151, 164-186, 196-218, 248-270, 280-302, 309-331, 336-358, 385-407 and 422-444 637910013744 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 637910013746 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 637910013747 HMMPfam hit to PF07944, Protein of unknown function DUF1680, score 2.8e-241 637910013748 amidophosphoribosyltransferase; Provisional; Region: PRK09246 637910013749 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 637910013750 active site 637910013751 tetramer interface [polypeptide binding]; other site 637910013752 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637910013753 active site 637910013754 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 9.5e-13 637910013755 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 637910013756 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 3e-70 637910013757 PS00443 Glutamine amidotransferases class-II active site. 637910013758 colicin V production protein; Provisional; Region: PRK10845 637910013759 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 637910013760 HMMPfam hit to PF02674, Colicin V production protein, score 1.1e-60 637910013761 4 transmembrane helices predicted for ROD27241 by TMHMM2.0 at aa 4-26, 31-53, 63-85 and 98-120 637910013762 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013763 cell division protein DedD; Provisional; Region: PRK11633 637910013764 Sporulation related domain; Region: SPOR; pfam05036 637910013765 HMMPfam hit to PF05036, Sporulation/cell division region, bacteria, score 2.6e-15 637910013766 1 transmembrane helix predicted for ROD27261 by TMHMM2.0 at aa 10-27 637910013767 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 637910013768 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637910013769 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637910013770 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 0.0001 637910013771 HMMPfam hit to PF08245, Mur ligase, central, score 1.1e-06 637910013772 PS01012 Folylpolyglutamate synthase signature 2. 637910013773 PS01011 Folylpolyglutamate synthase signature 1. 637910013774 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 637910013775 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 637910013776 HMMPfam hit to PF01039, Carboxyl transferase, score 9.6e-13 637910013777 hypothetical protein; Provisional; Region: PRK10847 637910013778 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 637910013779 4 transmembrane helices predicted for ROD27291 by TMHMM2.0 at aa 27-49, 71-93, 158-180 and 190-208 637910013780 HMMPfam hit to PF09335, SNARE associated Golgi protein, score 3.1e-06 637910013781 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 637910013782 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 637910013783 dimerization interface 3.5A [polypeptide binding]; other site 637910013784 active site 637910013785 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 4.9e-31 637910013786 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 8.9e-38 637910013787 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 637910013788 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 637910013789 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisation region, score 3.7e-56 637910013790 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013791 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD - binding, score 2.2e-39 637910013792 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 637910013793 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 637910013794 ligand binding site [chemical binding]; other site 637910013795 NAD binding site [chemical binding]; other site 637910013796 catalytic site [active] 637910013797 homodimer interface [polypeptide binding]; other site 637910013798 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region, score 4.8e-29 637910013799 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, score 1.5e-30 637910013800 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 637910013801 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 637910013802 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 637910013803 1 transmembrane helix predicted for ROD27331 by TMHMM2.0 at aa 312-334 637910013804 putative transporter; Provisional; Region: PRK12382 637910013805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910013806 putative substrate translocation pore; other site 637910013807 12 transmembrane helices predicted for ROD27341 by TMHMM2.0 at aa 20-42, 52-71, 83-105, 120-142, 149-171, 175-197, 210-232, 247-269, 276-298, 303-325, 338-360 and 370-389 637910013808 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013809 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 6.4e-33 637910013810 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013811 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 637910013812 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 637910013813 dimer interface [polypeptide binding]; other site 637910013814 active site 637910013815 HMMPfam hit to PF02801, beta-ketoacyl synthase, C-terminal, score 5e-43 637910013816 HMMPfam hit to PF00109, beta-ketoacyl synthase, N-terminal, score 7.4e-55 637910013817 PS00606 beta-ketoacyl synthases active site. 637910013818 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013819 Uncharacterized conserved protein [Function unknown]; Region: COG4121 637910013820 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 637910013821 HMMPfam hit to PF05430, Protein of unknown function DUF752, score 1e-144 637910013822 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 1.2e-59 637910013823 PS00659 Glycosyl hydrolases family 5 signature. 637910013824 YfcL protein; Region: YfcL; pfam08891 637910013825 HMMPfam hit to PF08891, YfcL protein, score 2.2e-46 637910013826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 637910013827 HMMPfam hit to PF04315, Protein of unknown function DUF462, score 6e-149 637910013828 hypothetical protein; Provisional; Region: PRK10621 637910013829 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 637910013830 8 transmembrane helices predicted for ROD27391 by TMHMM2.0 at aa 7-29, 51-73, 85-104, 108-127, 139-158, 163-182, 195-217 and 237-255 637910013831 HMMPfam hit to PF01925, Protein of unknown function DUF81, score 5.5e-60 637910013832 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013833 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 637910013834 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 637910013835 HMMPfam hit to PF03411, Peptidase M74, penicillin-insensitive murein endopeptidase, score 8.5e-197 637910013836 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 637910013837 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 637910013838 Tetramer interface [polypeptide binding]; other site 637910013839 active site 637910013840 FMN-binding site [chemical binding]; other site 637910013841 HMMPfam hit to PF01264, Chorismate synthase, score 9.7e-237 637910013842 PS00789 Chorismate synthase signature 3. 637910013843 PS00788 Chorismate synthase signature 2. 637910013844 PS00787 Chorismate synthase signature 1. 637910013845 HemK family putative methylases; Region: hemK_fam; TIGR00536 637910013846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910013847 S-adenosylmethionine binding site [chemical binding]; other site 637910013848 HMMPfam hit to PF05175, Methyltransferase small, score 1.1e-09 637910013849 PS00092 N-6 Adenine-specific DNA methylases signature. 637910013850 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013851 hypothetical protein; Provisional; Region: PRK04946 637910013852 Smr domain; Region: Smr; pfam01713 637910013853 HMMPfam hit to PF01713, Smr protein/MutS2 C-terminal, score 1.4e-30 637910013854 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637910013855 catalytic core [active] 637910013856 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 7.2e-10 637910013857 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 637910013858 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 637910013859 substrate binding site [chemical binding]; other site 637910013860 oxyanion hole (OAH) forming residues; other site 637910013861 trimer interface [polypeptide binding]; other site 637910013862 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 637910013863 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 637910013864 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 0.00058 637910013865 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 1.6e-41 637910013866 PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 637910013867 HMMPfam hit to PF02737, 3-hydroxyacyl-CoA dehydrogenase, NAD-binding, score 1.8e-87 637910013868 HMMPfam hit to PF00378, Crotonase, core, score 4.1e-63 637910013869 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 637910013870 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 637910013871 dimer interface [polypeptide binding]; other site 637910013872 active site 637910013873 HMMPfam hit to PF02803, Thiolase, score 2.4e-54 637910013874 PS00099 Thiolases active site. 637910013875 PS00737 Thiolases signature 2. 637910013876 HMMPfam hit to PF00108, Thiolase, score 8.8e-64 637910013877 PS00098 Thiolases acyl-enzyme intermediate signature. 637910013878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 637910013879 HMMPfam hit to PF04175, Conserved hypothetical protein CHP00743, score 1e-61 637910013880 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 637910013881 HMMPfam hit to PF03349, Membrane protein involved in aromatic hydrocarbon degradation, score 2.6e-189 637910013882 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 637910013883 PS00017 ATP/GTP-binding site motif A (P-loop). 637910013884 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 637910013885 HMMPfam hit to PF04333, VacJ-like lipoprotein, score 2.2e-120 637910013886 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013887 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 637910013888 7 transmembrane helices predicted for ROD27501 by TMHMM2.0 at aa 10-30, 133-155, 165-187, 208-230, 261-280, 287-306 and 326-348 637910013889 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013890 pseudogene, C-terminus missing, fragment 637910013891 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 637910013892 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 637910013893 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 637910013894 MarR family; Region: MarR_2; pfam12802 637910013895 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637910013896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637910013897 Coenzyme A binding pocket [chemical binding]; other site 637910013898 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 2.1e-12 637910013899 Predicted helix-turn-helix motif with score 1450.000, SD 4.13 at aa 51-72, sequence LTAAQLVQILGLEKSSVSRMLA 637910013900 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.3e-18 637910013901 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 637910013902 HMMPfam hit to PF03691, Protein of unknown function UPF0167, score 4e-11 637910013903 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013904 1 transmembrane helix predicted for ROD27581 by TMHMM2.0 at aa 4-26 637910013905 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 637910013906 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910013907 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637910013908 dimerization interface [polypeptide binding]; other site 637910013909 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.7e-20 637910013910 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 4.2e-17 637910013911 PS00044 Bacterial regulatory proteins, lysR family signature. 637910013912 Predicted helix-turn-helix motif with score 1620.000, SD 4.70 at aa 21-42, sequence GNFARAAEELSLTEGAISRQIA 637910013913 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 637910013914 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 637910013915 HMMPfam hit to PF00753, beta-lactamase-like, score 1.2e-23 637910013916 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 637910013917 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637910013918 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637910013919 HMMPfam hit to PF03797, Autotransporter beta-domain, score 7.7e-32 637910013920 PS00583 pfkB family of carbohydrate kinases signature 1. 637910013921 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 637910013922 HMMPfam hit to PF04965, GPW/gp25, score 3.5e-17 637910013923 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 637910013924 ImpE protein; Region: ImpE; pfam07024 637910013925 HMMPfam hit to PF07024, Predicted virulence protein, SciE type, score 1e-77 637910013926 PS00017 ATP/GTP-binding site motif A (P-loop). 637910013927 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 637910013928 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 637910013929 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 637910013930 PS00147 Arginase family signature 1. 637910013931 HMMPfam hit to PF04524, Rhs element Vgr protein, score 1.4e-53 637910013932 pseudogene, truncated by frameshift mutation, however the frameshift occurs at a poly A tract therefore the full length gene may still be expressed via transcriptional slipage 637910013933 HMMPfam hit to PF06744, Protein of unknown function DUF1215, score 2e-32 637910013934 HMMPfam hit to PF06761, ImcF-related, score 9.1e-58 637910013935 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 637910013936 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637910013937 ligand binding site [chemical binding]; other site 637910013938 HMMPfam hit to PF00691, Outer membrane protein, OmpA/MotB, C-terminal, score 1.1e-27 637910013939 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 637910013940 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 637910013941 HMMPfam hit to PF05936, Protein of unknown function DUF876, bacterial, score 8.4e-241 637910013942 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 637910013943 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013944 Protein of unknown function (DUF796); Region: DUF796; pfam05638 637910013945 HMMPfam hit to PF05638, Virulence factor for secretion apparatus, score 8.1e-60 637910013946 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 637910013947 Protein of unknown function (DUF877); Region: DUF877; pfam05943 637910013948 HMMPfam hit to PF05943, Protein of unknown function DUF877, score 0 637910013949 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 637910013950 HMMPfam hit to PF05591, Uncharacterised conserved protein UCP028301, score 2.9e-102 637910013951 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637910013952 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 2.2e-17 637910013953 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 637910013954 PapC N-terminal domain; Region: PapC_N; pfam13954 637910013955 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637910013956 PapC C-terminal domain; Region: PapC_C; pfam13953 637910013957 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 5.2e-239 637910013958 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 637910013959 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 637910013960 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637910013961 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637910013962 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 1e-09 637910013963 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 1e-54 637910013964 PS00635 Gram-negative pili assembly chaperone signature. 637910013965 1 transmembrane helix predicted for ROD27791 by TMHMM2.0 at aa 7-29 637910013966 Fimbrial protein; Region: Fimbrial; cl01416 637910013967 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 7.6e-21 637910013968 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 637910013969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910013970 Walker A motif; other site 637910013971 ATP binding site [chemical binding]; other site 637910013972 Walker B motif; other site 637910013973 arginine finger; other site 637910013974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910013975 Walker A motif; other site 637910013976 ATP binding site [chemical binding]; other site 637910013977 Walker B motif; other site 637910013978 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 637910013979 HMMPfam hit to PF07724, ATPase AAA-2, score 1.1e-83 637910013980 PS00017 ATP/GTP-binding site motif A (P-loop). 637910013981 HMMPfam hit to PF00004, AAA ATPase, core, score 5.6e-10 637910013982 PS00870 Chaperonins clpA/B signature 1. 637910013983 PS00017 ATP/GTP-binding site motif A (P-loop). 637910013984 HMMPfam hit to PF02861, Clp, N-terminal, score 0.038 637910013985 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 637910013986 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 637910013987 HMMPfam hit to PF05947, Protein of unknown function DUF879, bacterial, score 9.5e-292 637910013988 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910013989 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 637910013990 HMMPfam hit to PF06996, Protein of unknown function DUF1305, score 3e-124 637910013991 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 637910013992 HMMPfam hit to PF06812, ImpA, N-terminal, score 1e-22 637910013993 PS00017 ATP/GTP-binding site motif A (P-loop). 637910013994 Fimbrial protein; Region: Fimbrial; pfam00419 637910013995 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 0.00076 637910013996 Glycosyltransferase (GlcNAc); Region: GlcNAc; pfam11397 637910013997 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 637910013998 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637910013999 ligand binding site [chemical binding]; other site 637910014000 1 transmembrane helix predicted for ROD27871 by TMHMM2.0 at aa 430-452 637910014001 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910014002 HMMPfam hit to PF00691, Outer membrane protein, OmpA/MotB, C-terminal, score 7.7e-28 637910014003 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 637910014004 HMMPfam hit to PF08786, Protein of unknown function DUF1795, score 3.4e-31 637910014005 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637910014006 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637910014007 Walker A/P-loop; other site 637910014008 ATP binding site [chemical binding]; other site 637910014009 Q-loop/lid; other site 637910014010 ABC transporter signature motif; other site 637910014011 Walker B; other site 637910014012 D-loop; other site 637910014013 H-loop/switch region; other site 637910014014 HMMPfam hit to PF00005, ABC transporter related, score 1.5e-67 637910014015 PS00211 ABC transporters family signature. 637910014016 PS00017 ATP/GTP-binding site motif A (P-loop). 637910014017 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 637910014018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910014019 dimer interface [polypeptide binding]; other site 637910014020 conserved gate region; other site 637910014021 putative PBP binding loops; other site 637910014022 ABC-ATPase subunit interface; other site 637910014023 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2e-22 637910014024 4 transmembrane helices predicted for ROD27901 by TMHMM2.0 at aa 21-43, 72-94, 115-137 and 216-238 637910014025 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910014026 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637910014027 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 637910014028 substrate binding pocket [chemical binding]; other site 637910014029 membrane-bound complex binding site; other site 637910014030 hinge residues; other site 637910014031 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 9.9e-71 637910014032 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 637910014033 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 637910014034 putative acyl-acceptor binding pocket; other site 637910014035 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltransferase, score 1.5e-147 637910014036 1 transmembrane helix predicted for ROD27921 by TMHMM2.0 at aa 20-42 637910014037 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 637910014038 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910014039 HMMPfam hit to PF01609, Transposase, IS4-like, score 5.4e-13 637910014040 1 transmembrane helix predicted for ROD27931 by TMHMM2.0 at aa 309-331 637910014041 aminotransferase; Validated; Region: PRK08175 637910014042 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637910014043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910014044 homodimer interface [polypeptide binding]; other site 637910014045 catalytic residue [active] 637910014046 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 3.3e-61 637910014047 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 637910014048 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 637910014049 GAF domain; Region: GAF; pfam01590 637910014050 Histidine kinase; Region: His_kinase; pfam06580 637910014051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910014052 ATP binding site [chemical binding]; other site 637910014053 Mg2+ binding site [ion binding]; other site 637910014054 G-X-G motif; other site 637910014055 6 transmembrane helices predicted for ROD27951 by TMHMM2.0 at aa 4-26, 46-65, 75-97, 106-128, 138-160 and 169-191 637910014056 HMMPfam hit to PF07694, 5TM Receptors of the LytS-YhcK type, transmembrane region, score 1.2e-35 637910014057 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910014058 HMMPfam hit to PF01590, GAF, score 2.1e-05 637910014059 HMMPfam hit to PF06580, Histidine kinase internal region, score 1.3e-40 637910014060 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 6.5e-17 637910014061 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 637910014062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910014063 active site 637910014064 phosphorylation site [posttranslational modification] 637910014065 intermolecular recognition site; other site 637910014066 dimerization interface [polypeptide binding]; other site 637910014067 LytTr DNA-binding domain; Region: LytTR; pfam04397 637910014068 HMMPfam hit to PF00072, Response regulator receiver, score 3.5e-35 637910014069 HMMPfam hit to PF04397, LytTr DNA-binding region, score 9e-28 637910014070 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 637910014071 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910014072 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 0.00033 637910014073 Predicted helix-turn-helix motif with score 1662.000, SD 4.85 at aa 198-219, sequence LSRESVATFFNITPNHLSRLFT 637910014074 PS00041 Bacterial regulatory proteins, araC family signature. 637910014075 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 6.2e-13 637910014076 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 637910014077 DNA-binding site [nucleotide binding]; DNA binding site 637910014078 RNA-binding motif; other site 637910014079 HMMPfam hit to PF00313, Cold-shock protein, DNA-binding, score 3e-05 637910014080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 637910014081 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 637910014082 HMMPfam hit to PF06042, Protein of unknown function DUF925, bacterial, score 3e-56 637910014083 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 637910014084 dimerization domain swap beta strand [polypeptide binding]; other site 637910014085 regulatory protein interface [polypeptide binding]; other site 637910014086 active site 637910014087 regulatory phosphorylation site [posttranslational modification]; other site 637910014088 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 637910014089 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 637910014090 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 637910014091 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 637910014092 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637910014093 active site 637910014094 phosphorylation site [posttranslational modification] 637910014095 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 9.7e-06 637910014096 HMMPfam hit to PF02896, PEP-utilizing enzyme, score 8.4e-150 637910014097 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile region, score 2.2e-19 637910014098 HMMPfam hit to PF05524, Phosphotransferase system, PEP-utilising enzyme, N-terminal, score 3.2e-06 637910014099 HMMPfam hit to PF00381, Phosphotransferase system, phosphocarrier HPr protein, score 0.00018 637910014100 exoaminopeptidase; Provisional; Region: PRK09961 637910014101 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 637910014102 metal binding site [ion binding]; metal-binding site 637910014103 HMMPfam hit to PF05343, Peptidase M42, score 1.4e-112 637910014104 aminopeptidase; Provisional; Region: PRK09795 637910014105 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 637910014106 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 637910014107 active site 637910014108 HMMPfam hit to PF00557, Peptidase M24, catalytic core, score 2.1e-67 637910014109 HMMPfam hit to PF01321, Creatinase, score 0.00015 637910014110 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 637910014111 10 transmembrane helices predicted for ROD28041 by TMHMM2.0 at aa 46-68, 97-119, 126-145, 155-177, 198-220, 240-262, 275-297, 317-335, 342-364 and 379-401 637910014112 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 0.00011 637910014113 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 637910014114 active site 637910014115 P-loop; other site 637910014116 phosphorylation site [posttranslational modification] 637910014117 HMMPfam hit to PF02379, Phosphotransferase system, fructose-specific IIB subunit, score 1.6e-57 637910014118 glucokinase; Provisional; Region: glk; PRK00292 637910014119 glucokinase, proteobacterial type; Region: glk; TIGR00749 637910014120 HMMPfam hit to PF02685, glucokinase, score 2e-191 637910014121 1 transmembrane helix predicted for ROD28061 by TMHMM2.0 at aa 244-266 637910014122 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 637910014123 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 637910014124 Cl- selectivity filter; other site 637910014125 Cl- binding residues [ion binding]; other site 637910014126 pore gating glutamate residue; other site 637910014127 dimer interface [polypeptide binding]; other site 637910014128 11 transmembrane helices predicted for ROD28071 by TMHMM2.0 at aa 9-31, 55-77, 90-112, 148-170, 186-208, 223-245, 258-280, 295-317, 322-341, 345-363 and 376-398 637910014129 HMMPfam hit to PF00654, Chloride channel, core, score 5.8e-05 637910014130 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 637910014131 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 637910014132 dimer interface [polypeptide binding]; other site 637910014133 PYR/PP interface [polypeptide binding]; other site 637910014134 TPP binding site [chemical binding]; other site 637910014135 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637910014136 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 637910014137 TPP-binding site [chemical binding]; other site 637910014138 dimer interface [polypeptide binding]; other site 637910014139 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 637910014140 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-terminal TPP-binding, score 7e-17 637910014141 PS00187 Thiamine pyrophosphate enzymes signature. 637910014142 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central region, score 1e-11 637910014143 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-terminal TPP binding region, score 1.3e-74 637910014144 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 637910014145 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637910014146 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637910014147 active site 637910014148 catalytic tetrad [active] 637910014149 HMMPfam hit to PF00248, Aldo/keto reductase, score 3.3e-65 637910014150 1 transmembrane helix predicted for ROD28101 by TMHMM2.0 at aa 5-27 637910014151 manganese transport protein MntH; Reviewed; Region: PRK00701 637910014152 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 637910014153 11 transmembrane helices predicted for ROD28111 by TMHMM2.0 at aa 17-39, 54-76, 96-118, 123-145, 157-176, 196-218, 239-261, 281-303, 324-343, 348-370 and 391-410 637910014154 HMMPfam hit to PF01566, Natural resistance-associated macrophage protein, score 2.6e-192 637910014155 1 transmembrane helix predicted for ROD28121 by TMHMM2.0 at aa 12-34 637910014156 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 637910014157 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 637910014158 Nucleoside recognition; Region: Gate; pfam07670 637910014159 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 637910014160 HMMPfam hit to PF01773, Na+ dependent nucleoside transporter score 8.9e-32 637910014161 9 transmembrane helices predicted for ROD28131 by TMHMM2.0 at aa 4-23, 36-57, 86-108, 167-189, 193-215, 244-266, 276-298, 340-362 and 377-399 637910014162 HMMPfam hit to PF07670, Nucleoside recognition, score 3.6e-18 637910014163 HMMPfam hit to PF07662, Na+ dependent nucleoside transporter C-terminal, score 9.1e-107 637910014164 MASE1; Region: MASE1; pfam05231 637910014165 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637910014166 diguanylate cyclase; Region: GGDEF; smart00267 637910014167 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637910014168 HMMPfam hit to PF00563, EAL, score 2.3e-97 637910014169 HMMPfam hit to PF00990, GGDEF, score 6.5e-05 637910014170 HMMPfam hit to PF05231, MASE1, score 1.6e-48 637910014171 9 transmembrane helices predicted for ROD28141 by TMHMM2.0 at aa 13-32, 42-59, 64-83, 87-104, 125-147, 162-184, 214-236, 246-268 and 289-311 637910014172 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 637910014173 HMMPfam hit to PF07037, Protein of unknown function DUF1323, score 5.2e-70 637910014174 Predicted helix-turn-helix motif with score 1895.000, SD 5.64 at aa 1-22, sequence MTPEELASLTGYSRQTINKWVR 637910014175 Winged helix-turn helix; Region: HTH_29; pfam13551 637910014176 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 637910014177 HMMPfam hit to PF07037, Protein of unknown function DUF1323, score 1.3e-78 637910014178 Predicted helix-turn-helix motif with score 2380.000, SD 7.29 at aa 8-29, sequence MTTEELAQCLGVARQTVNRWVR 637910014179 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 637910014180 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 637910014181 active site 637910014182 HIGH motif; other site 637910014183 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 637910014184 active site 637910014185 KMSKS motif; other site 637910014186 HMMPfam hit to PF00749, Glutamyl/glutaminyl-tRNA synthetase, class Ic, score 8.4e-182 637910014187 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 637910014188 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 637910014189 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 637910014190 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 637910014191 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 637910014192 HMMPfam hit to PF04524, Rhs element Vgr protein, score 4.7e-52 637910014193 HMMPfam hit to PF06715, Gp5, C-terminal, score 0.0017 637910014194 HMMPfam hit to PF06715, Gp5, C-terminal, score 0.008 637910014195 pseudogene, C-terminus missing, N-terminal part fragmented by frameshift mutation and premature stop codon; Repeated at 2798382..2794736 637910014196 HMMPfam hit to PF05593, YD repeat, score 3.6 637910014197 HMMPfam hit to PF05593, YD repeat, score 0.014 637910014198 HMMPfam hit to PF05593, YD repeat, score 0.0037 637910014199 HMMPfam hit to PF05593, YD repeat, score 0.00044 637910014200 HMMPfam hit to PF05593, YD repeat, score 0.0029 637910014201 HMMPfam hit to PF05593, YD repeat, score 0.00021 637910014202 HMMPfam hit to PF05593, YD repeat, score 9.3e-07 637910014203 HMMPfam hit to PF05593, YD repeat, score 0.19 637910014204 HMMPfam hit to PF05593, YD repeat, score 0.00029 637910014205 HMMPfam hit to PF05593, YD repeat, score 0.0065 637910014206 HMMPfam hit to PF05593, YD repeat, score 0.047 637910014207 HMMPfam hit to PF03527, RHS protein, score 7.8e-23 637910014208 HMMPfam hit to PF05593, YD repeat, score 2.1 637910014209 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910014210 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910014211 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910014212 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910014213 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910014214 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910014215 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910014216 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910014217 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910014218 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910014219 Transposase; Region: HTH_Tnp_1; pfam01527 637910014220 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910014221 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910014222 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910014223 pseudogene, N-terminus deleted by ISCro1 insertion 637910014224 1 transmembrane helix predicted for ROD28281 by TMHMM2.0 at aa 102-121 637910014225 pseudogene, N-terminus missing, C-terminus deleted by ISCro1 insertion 637910014226 HMMPfam hit to PF04524, Rhs element Vgr protein, score 1.7e-11 637910014227 Transposase; Region: HTH_Tnp_1; pfam01527 637910014228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910014229 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910014230 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910014231 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910014232 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910014233 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910014234 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910014235 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910014236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910014237 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910014238 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910014239 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910014240 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910014241 SecY interacting protein Syd; Provisional; Region: PRK04968 637910014242 HMMPfam hit to PF07348, Syd, score 2.6e-117 637910014243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 637910014244 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 637910014245 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 637910014246 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 7.9e-09 637910014247 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 637910014248 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 637910014249 HMMPfam hit to PF03641, Conserved hypothetical protein CHP00730, score 5.4e-55 637910014250 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 637910014251 serine transporter; Region: stp; TIGR00814 637910014252 11 transmembrane helices predicted for ROD28361 by TMHMM2.0 at aa 24-41, 45-67, 103-125, 140-157, 164-186, 206-228, 249-271, 300-322, 351-373, 377-394 and 406-428 637910014253 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910014254 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 637910014255 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 637910014256 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 637910014257 HMMPfam hit to PF03315, Serine dehydratase subunit beta, score 2.3e-106 637910014258 HMMPfam hit to PF03313, Serine dehydratase subunit alpha, score 4.3e-203 637910014259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637910014260 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637910014261 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637910014262 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 1.2e-17 637910014263 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.2e-27 637910014264 flap endonuclease-like protein; Provisional; Region: PRK09482 637910014265 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 637910014266 active site 637910014267 metal binding site 1 [ion binding]; metal-binding site 637910014268 putative 5' ssDNA interaction site; other site 637910014269 metal binding site 3; metal-binding site 637910014270 metal binding site 2 [ion binding]; metal-binding site 637910014271 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 637910014272 putative DNA binding site [nucleotide binding]; other site 637910014273 putative metal binding site [ion binding]; other site 637910014274 HMMPfam hit to PF02739, 5'-3' exonuclease, score 7.4e-21 637910014275 HMMPfam hit to PF01367, 5'-3' exonuclease, score 1.2e-25 637910014276 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 637910014277 intersubunit interface [polypeptide binding]; other site 637910014278 active site 637910014279 Zn2+ binding site [ion binding]; other site 637910014280 HMMPfam hit to PF00596, Class II aldolase/adducin, N-terminal, score 1e-72 637910014281 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910014282 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637910014283 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910014284 DNA binding site [nucleotide binding] 637910014285 domain linker motif; other site 637910014286 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 637910014287 dimerization interface [polypeptide binding]; other site 637910014288 ligand binding site [chemical binding]; other site 637910014289 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 2.4e-05 637910014290 Predicted helix-turn-helix motif with score 1340.000, SD 3.75 at aa 3-24, sequence KTVEQIADDLNLSVTTVRLVLN 637910014291 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 637910014292 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 637910014293 putative ligand binding site [chemical binding]; other site 637910014294 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 4.2e-06 637910014295 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910014296 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637910014297 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637910014298 TM-ABC transporter signature motif; other site 637910014299 8 transmembrane helices predicted for ROD28441 by TMHMM2.0 at aa 7-24, 39-61, 68-90, 105-124, 149-171, 202-221, 242-264 and 279-297 637910014300 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 1.2e-70 637910014301 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 637910014302 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910014303 HMMPfam hit to PF01609, Transposase, IS4-like, score 9.3e-30 637910014304 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637910014305 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637910014306 Walker A/P-loop; other site 637910014307 ATP binding site [chemical binding]; other site 637910014308 Q-loop/lid; other site 637910014309 ABC transporter signature motif; other site 637910014310 Walker B; other site 637910014311 D-loop; other site 637910014312 H-loop/switch region; other site 637910014313 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637910014314 HMMPfam hit to PF00005, ABC transporter related, score 5.9e-28 637910014315 PS00211 ABC transporters family signature. 637910014316 HMMPfam hit to PF00005, ABC transporter related, score 6.8e-55 637910014317 PS00017 ATP/GTP-binding site motif A (P-loop). 637910014318 L-fucose isomerase; Provisional; Region: fucI; PRK10991 637910014319 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 637910014320 hexamer (dimer of trimers) interface [polypeptide binding]; other site 637910014321 trimer interface [polypeptide binding]; other site 637910014322 substrate binding site [chemical binding]; other site 637910014323 Mn binding site [ion binding]; other site 637910014324 HMMPfam hit to PF07881, L-fucose isomerase, N-terminal-1, score 4.2e-124 637910014325 HMMPfam hit to PF07882, L-fucose isomerase, N-terminal-2, score 8.6e-128 637910014326 HMMPfam hit to PF02952, L-fucose isomerase-like, C-terminal, score 6e-109 637910014327 L-fuculokinase; Provisional; Region: PRK10331 637910014328 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 637910014329 nucleotide binding site [chemical binding]; other site 637910014330 HMMPfam hit to PF00370, Carbohydrate kinase, FGGY, score 4.3e-98 637910014331 PS00933 FGGY family of carbohydrate kinases signature 1. 637910014332 HMMPfam hit to PF02782, Carbohydrate kinase, FGGY, score 1e-71 637910014333 PS00445 FGGY family of carbohydrate kinases signature 2. 637910014334 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 637910014335 HMMPfam hit to PF05025, RbsD or FucU transport, score 3.5e-56 637910014336 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 637910014337 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 637910014338 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637910014339 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 5e-21 637910014340 PS00894 Bacterial regulatory proteins, deoR family signature. 637910014341 Predicted helix-turn-helix motif with score 1372.000, SD 3.86 at aa 19-40, sequence LTTDALSVQLNVSKETIRRDLS 637910014342 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 3.1e-68 637910014343 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 637910014344 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 637910014345 HMMPfam hit to PF01728, Ribosomal RNA methyltransferase RrmJ/FtsJ, score 5.1e-07 637910014346 hypothetical protein; Provisional; Region: PRK10873 637910014347 4 transmembrane helices predicted for ROD28521 by TMHMM2.0 at aa 5-27, 37-59, 66-88 and 98-120 637910014348 HMMPfam hit to PF04241, Protein of unknown function DUF423, score 7.3e-53 637910014349 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 637910014350 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910014351 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 637910014352 dimerization interface [polypeptide binding]; other site 637910014353 substrate binding pocket [chemical binding]; other site 637910014354 HMMPfam hit to PF03466, LysR, substrate-binding, score 9e-46 637910014355 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 8.5e-22 637910014356 PS00044 Bacterial regulatory proteins, lysR family signature. 637910014357 Predicted helix-turn-helix motif with score 1791.000, SD 5.29 at aa 21-42, sequence LSFTRAAEELFVTQAAVSHQIK 637910014358 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 637910014359 HMMPfam hit to PF06004, Protein of unknown function DUF903, bacterial, score 1.9e-44 637910014360 1 transmembrane helix predicted for ROD28541 by TMHMM2.0 at aa 4-26 637910014361 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910014362 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 637910014363 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 637910014364 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637910014365 catalytic residue [active] 637910014366 HMMPfam hit to PF00266, Aminotransferase, class V, score 4.2e-199 637910014367 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910014368 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 637910014369 CsdA-binding activator; Provisional; Region: PRK15019 637910014370 HMMPfam hit to PF02657, Fe-S metabolism associated SufE, score 1.3e-61 637910014371 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 637910014372 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 637910014373 putative ATP binding site [chemical binding]; other site 637910014374 putative substrate interface [chemical binding]; other site 637910014375 1 transmembrane helix predicted for ROD28571 by TMHMM2.0 at aa 235-257 637910014376 HMMPfam hit to PF00899, UBA/THIF-type NAD/FAD binding fold, score 2.5e-58 637910014377 murein transglycosylase A; Provisional; Region: mltA; PRK11162 637910014378 MltA specific insert domain; Region: MltA; pfam03562 637910014379 3D domain; Region: 3D; pfam06725 637910014380 HMMPfam hit to PF06725, 3D, score 6.2e-34 637910014381 HMMPfam hit to PF03562, MltA, score 1e-75 637910014382 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910014383 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 637910014384 AMIN domain; Region: AMIN; pfam11741 637910014385 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 637910014386 active site 637910014387 metal binding site [ion binding]; metal-binding site 637910014388 HMMPfam hit to PF01520, Cell wall hydrolase/autolysin, catalytic, score 1.7e-106 637910014389 N-acetylglutamate synthase; Validated; Region: PRK05279 637910014390 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 637910014391 putative feedback inhibition sensing region; other site 637910014392 putative nucleotide binding site [chemical binding]; other site 637910014393 putative substrate binding site [chemical binding]; other site 637910014394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637910014395 Coenzyme A binding pocket [chemical binding]; other site 637910014396 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 3.9e-37 637910014397 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.5e-10 637910014398 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 637910014399 AAA domain; Region: AAA_30; pfam13604 637910014400 Family description; Region: UvrD_C_2; pfam13538 637910014401 PS00017 ATP/GTP-binding site motif A (P-loop). 637910014402 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 637910014403 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 637910014404 HMMPfam hit to PF00580, DNA helicase, UvrD/REP type, score 3e-160 637910014405 PS00017 ATP/GTP-binding site motif A (P-loop). 637910014406 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 637910014407 protease3; Provisional; Region: PRK15101 637910014408 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 637910014409 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 637910014410 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 637910014411 HMMPfam hit to PF05193, Peptidase M16, C-terminal, score 5.6e-17 637910014412 HMMPfam hit to PF05193, Peptidase M16, C-terminal, score 1.3e-27 637910014413 HMMPfam hit to PF00675, Peptidase M16, N-terminal, score 3.2e-54 637910014414 PS00143 Insulinase family, zinc-binding region signature. 637910014415 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 637910014416 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 637910014417 HMMPfam hit to PF04257, Exodeoxyribonuclease V, RecC subunit, score 0 637910014418 hypothetical protein; Provisional; Region: PRK10332 637910014419 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 637910014420 1 transmembrane helix predicted for ROD28651 by TMHMM2.0 at aa 15-37 637910014421 PS00409 Prokaryotic N-terminal methylation site. 637910014422 hypothetical protein; Provisional; Region: PRK11521 637910014423 1 transmembrane helix predicted for ROD28661 by TMHMM2.0 at aa 7-29 637910014424 hypothetical protein; Provisional; Region: PRK10557 637910014425 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 637910014426 HMMPfam hit to PF07963, Prepilin-type cleavage/methylation, N-terminal, score 2.8e-05 637910014427 1 transmembrane helix predicted for ROD28671 by TMHMM2.0 at aa 7-29 637910014428 PS00409 Prokaryotic N-terminal methylation site. 637910014429 hypothetical protein; Provisional; Region: PRK10506 637910014430 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 637910014431 1 transmembrane helix predicted for ROD28681 by TMHMM2.0 at aa 7-29 637910014432 HMMPfam hit to PF07963, Prepilin-type cleavage/methylation, N-terminal, score 0.002 637910014433 PS00409 Prokaryotic N-terminal methylation site. 637910014434 thymidylate synthase; Reviewed; Region: thyA; PRK01827 637910014435 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 637910014436 dimerization interface [polypeptide binding]; other site 637910014437 active site 637910014438 HMMPfam hit to PF00303, Thymidylate synthase, C-terminal, score 5.8e-152 637910014439 PS00091 Thymidylate synthase active site. 637910014440 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 637910014441 HMMPfam hit to PF01790, Prolipoprotein diacylglyceryl transferase, score 3.1e-146 637910014442 5 transmembrane helices predicted for ROD28701 by TMHMM2.0 at aa 15-37, 58-80, 95-117, 223-245 and 260-282 637910014443 PS01311 Prolipoprotein diacylglyceryl transferase signature. 637910014444 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 637910014445 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 637910014446 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 637910014447 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 637910014448 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 637910014449 HMMPfam hit to PF02896, PEP-utilizing enzyme, score 5.9e-161 637910014450 PS00742 PEP-utilizing enzymes signature 2. 637910014451 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile region, score 4.6e-23 637910014452 PS00370 PEP-utilizing enzymes phosphorylation site signature. 637910014453 HMMPfam hit to PF05524, Phosphotransferase system, PEP-utilising enzyme, N-terminal, score 1.1e-41 637910014454 HMMPfam hit to PF01590, GAF, score 5.9e-27 637910014455 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 637910014456 putative active site [active] 637910014457 Ap4A binding site [chemical binding]; other site 637910014458 nudix motif; other site 637910014459 putative metal binding site [ion binding]; other site 637910014460 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 8.2e-31 637910014461 PS00893 mutT domain signature. 637910014462 PS00589 PTS HPR component serine phosphorylation site signature. 637910014463 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 637910014464 putative DNA-binding cleft [nucleotide binding]; other site 637910014465 putative DNA clevage site; other site 637910014466 molecular lever; other site 637910014467 HMMPfam hit to PF02976, DNA mismatch repair enzyme MutH, score 1.5e-58 637910014468 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 637910014469 HMMPfam hit to PF03741, Integral membrane protein TerC, score 4e-46 637910014470 7 transmembrane helices predicted for ROD28751 by TMHMM2.0 at aa 15-37, 50-69, 84-101, 122-139, 154-176, 183-202 and 212-230 637910014471 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 637910014472 HMMPfam hit to PF06004, Protein of unknown function DUF903, bacterial, score 2.3e-47 637910014473 1 transmembrane helix predicted for ROD28761 by TMHMM2.0 at aa 12-34 637910014474 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910014475 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637910014476 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637910014477 active site 637910014478 catalytic tetrad [active] 637910014479 HMMPfam hit to PF00248, Aldo/keto reductase, score 2.9e-49 637910014480 lysophospholipid transporter LplT; Provisional; Region: PRK11195 637910014481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910014482 10 transmembrane helices predicted for ROD28781 by TMHMM2.0 at aa 19-41, 51-73, 94-116, 162-184, 220-242, 257-279, 286-305, 309-331, 344-366 and 371-393 637910014483 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 3.4e-10 637910014484 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 637910014485 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 637910014486 putative acyl-acceptor binding pocket; other site 637910014487 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 637910014488 acyl-activating enzyme (AAE) consensus motif; other site 637910014489 putative AMP binding site [chemical binding]; other site 637910014490 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 8.7e-74 637910014491 PS00455 AMP-binding domain signature. 637910014492 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 2.4e-32 637910014493 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 637910014494 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910014495 DNA binding site [nucleotide binding] 637910014496 domain linker motif; other site 637910014497 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 637910014498 dimerization interface (closed form) [polypeptide binding]; other site 637910014499 ligand binding site [chemical binding]; other site 637910014500 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 2.7e-14 637910014501 Predicted helix-turn-helix motif with score 2178.000, SD 6.60 at aa 2-23, sequence ATIKDVARLAGVSVATVSRVIN 637910014502 PS00356 Bacterial regulatory proteins, lacI family signature. 637910014503 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 1.7e-25 637910014504 diaminopimelate decarboxylase; Provisional; Region: PRK11165 637910014505 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 637910014506 active site 637910014507 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637910014508 substrate binding site [chemical binding]; other site 637910014509 catalytic residues [active] 637910014510 dimer interface [polypeptide binding]; other site 637910014511 HMMPfam hit to PF00278, Orn/DAP/Arg decarboxylase 2, score 4.8e-38 637910014512 HMMPfam hit to PF02784, Orn/DAP/Arg decarboxylase 2, score 1.1e-93 637910014513 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 637910014514 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 637910014515 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 637910014516 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910014517 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 637910014518 putative dimerization interface [polypeptide binding]; other site 637910014519 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 3.5e-20 637910014520 Predicted helix-turn-helix motif with score 2041.000, SD 6.14 at aa 19-40, sequence GNLTEAARLLHTSQPTVSRELA 637910014521 PS00044 Bacterial regulatory proteins, lysR family signature. 637910014522 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.8e-43 637910014523 putative racemase; Provisional; Region: PRK10200 637910014524 aspartate racemase; Region: asp_race; TIGR00035 637910014525 HMMPfam hit to PF01177, Asp/Glu/hydantoin racemase, score 9e-61 637910014526 PS00924 Aspartate and glutamate racemases signature 2. 637910014527 PS00923 Aspartate and glutamate racemases signature 1. 637910014528 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 637910014529 HMMPfam hit to PF07883, Cupin 2, conserved barrel, score 1.4e-16 637910014530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910014531 dimer interface [polypeptide binding]; other site 637910014532 conserved gate region; other site 637910014533 putative PBP binding loops; other site 637910014534 ABC-ATPase subunit interface; other site 637910014535 7 transmembrane helices predicted for ROD28861 by TMHMM2.0 at aa 7-29, 69-91, 104-126, 153-175, 196-215, 225-247 and 256-278 637910014536 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.7e-09 637910014537 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910014538 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637910014539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910014540 dimer interface [polypeptide binding]; other site 637910014541 conserved gate region; other site 637910014542 putative PBP binding loops; other site 637910014543 ABC-ATPase subunit interface; other site 637910014544 6 transmembrane helices predicted for ROD28871 by TMHMM2.0 at aa 29-51, 99-121, 128-150, 165-184, 205-227 and 262-284 637910014545 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.4e-16 637910014546 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910014547 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 637910014548 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 637910014549 Walker A/P-loop; other site 637910014550 ATP binding site [chemical binding]; other site 637910014551 Q-loop/lid; other site 637910014552 ABC transporter signature motif; other site 637910014553 Walker B; other site 637910014554 D-loop; other site 637910014555 H-loop/switch region; other site 637910014556 TOBE domain; Region: TOBE; pfam03459 637910014557 HMMPfam hit to PF00005, ABC transporter related, score 2.2e-49 637910014558 PS00211 ABC transporters family signature. 637910014559 HMMPfam hit to PF08402, Transport-associated OB, type 2, score 0.0058 637910014560 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637910014561 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 637910014562 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 1.8e-20 637910014563 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 637910014564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910014565 putative substrate translocation pore; other site 637910014566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910014567 HMMPfam hit to PF00083, General substrate transporter score 3.2e-172 637910014568 12 transmembrane helices predicted for ROD28901 by TMHMM2.0 at aa 21-43, 63-83, 90-112, 116-138, 150-167, 177-199, 259-281, 296-318, 325-347, 362-384, 397-419 and 424-446 637910014569 PS00216 Sugar transport proteins signature 1. 637910014570 PS00217 Sugar transport proteins signature 2. 637910014571 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 637910014572 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 637910014573 NADP binding site [chemical binding]; other site 637910014574 homodimer interface [polypeptide binding]; other site 637910014575 active site 637910014576 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 1.5e-27 637910014577 PS00061 Short-chain dehydrogenases/reductases family signature. 637910014578 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 637910014579 HMMPfam hit to PF04962, 5-keto 4-deoxyuronate isomerase, score 1e-224 637910014580 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 637910014581 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 637910014582 HMMPfam hit to PF07676, WD40-like Beta Propeller, score 0.00031 637910014583 pseudogene, disrupted by IS102 insertion 637910014584 HMMPfam hit to PF06178, Oligogalacturonate-specific porin, score 1.2e-72 637910014585 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 637910014586 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910014587 HMMPfam hit to PF01609, Transposase, IS4-like, score 9.3e-30 637910014588 1 transmembrane helix predicted for ROD28971 by TMHMM2.0 at aa 5-27 637910014589 putative acyltransferase; Provisional; Region: PRK05790 637910014590 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 637910014591 dimer interface [polypeptide binding]; other site 637910014592 active site 637910014593 HMMPfam hit to PF02803, Thiolase, score 8.5e-93 637910014594 PS00099 Thiolases active site. 637910014595 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910014596 PS00737 Thiolases signature 2. 637910014597 HMMPfam hit to PF00108, Thiolase, score 5.1e-159 637910014598 PS00098 Thiolases acyl-enzyme intermediate signature. 637910014599 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 637910014600 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 637910014601 11 transmembrane helices predicted for ROD28991 by TMHMM2.0 at aa 13-30, 35-52, 86-108, 123-145, 152-174, 194-216, 236-258, 273-295, 334-356, 360-382 and 389-408 637910014602 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910014603 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 637910014604 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 637910014605 putative metal binding site [ion binding]; other site 637910014606 putative homodimer interface [polypeptide binding]; other site 637910014607 putative homotetramer interface [polypeptide binding]; other site 637910014608 putative homodimer-homodimer interface [polypeptide binding]; other site 637910014609 putative allosteric switch controlling residues; other site 637910014610 HMMPfam hit to PF02583, Protein of unknown function DUF156, score 1.5e-30 637910014611 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 637910014612 6 transmembrane helices predicted for ROD29031 by TMHMM2.0 at aa 10-32, 52-74, 89-111, 184-206, 216-238 and 259-281 637910014613 HMMPfam hit to PF03824, Nickel/cobalt transporter high-affinity, score 4.8e-60 637910014614 Predicted acetyltransferase [General function prediction only]; Region: COG2388 637910014615 Uncharacterized conserved protein [Function unknown]; Region: COG3592 637910014616 HMMPfam hit to PF06902, Protein of unknown function DUF1271, score 1.6e-42 637910014617 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 637910014618 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1.3e-15 637910014619 1 transmembrane helix predicted for ROD29061 by TMHMM2.0 at aa 145-167 637910014620 1 transmembrane helix predicted for ROD29071 by TMHMM2.0 at aa 5-27 637910014621 Mononegavirales mRNA-capping region V; Region: Mononeg_mRNAcap; pfam14318 637910014622 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 637910014623 Int/Topo IB signature motif; other site 637910014624 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 5.6e-52 637910014625 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 637910014626 Int/Topo IB signature motif; other site 637910014627 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 1e-51 637910014628 Fimbrial protein; Region: Fimbrial; cl01416 637910014629 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 1.3e-64 637910014630 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637910014631 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 3.1e-59 637910014632 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 637910014633 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637910014634 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637910014635 1 transmembrane helix predicted for ROD29141 by TMHMM2.0 at aa 13-32 637910014636 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 3.5e-67 637910014637 PS00635 Gram-negative pili assembly chaperone signature. 637910014638 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 4.5e-25 637910014639 outer membrane usher protein; Provisional; Region: PRK15193 637910014640 PapC N-terminal domain; Region: PapC_N; pfam13954 637910014641 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637910014642 PapC C-terminal domain; Region: PapC_C; pfam13953 637910014643 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 0 637910014644 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 637910014645 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 637910014646 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637910014647 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 4.3e-35 637910014648 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637910014649 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 1.5e-10 637910014650 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 637910014651 mannosyl binding site [chemical binding]; other site 637910014652 Fimbrial protein; Region: Fimbrial; cl01416 637910014653 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910014654 HMMPfam hit to PF09160, FimH, mannose-binding, score 1.8e-58 637910014655 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 0.00019 637910014656 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637910014657 Predicted helix-turn-helix motif with score 1311.000, SD 3.65 at aa 109-130, sequence YSIAERAKHRGISQKTLYNQRT 637910014658 HMMPfam hit to PF00563, EAL, score 3.9e-62 637910014659 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910014660 putative fimbrial protein TcfA; Provisional; Region: PRK15308 637910014661 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637910014662 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 637910014663 1 transmembrane helix predicted for ROD29231 by TMHMM2.0 at aa 7-29 637910014664 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 637910014665 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637910014666 HMMPfam hit to PF00563, EAL, score 6.1e-65 637910014667 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 637910014668 DNA binding residues [nucleotide binding] 637910014669 dimerization interface [polypeptide binding]; other site 637910014670 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 4.2e-05 637910014671 PS00622 Bacterial regulatory proteins, luxR family signature. 637910014672 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 637910014673 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 637910014674 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910014675 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 637910014676 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910014677 HMMPfam hit to PF01609, Transposase, IS4-like, score 9.3e-30 637910014678 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 637910014679 HMMPfam hit to PF06316, Virulence-related outer membrane protein, score 2e-10 637910014680 PS00694 Enterobacterial virulence outer membrane protein signature 1. 637910014681 1 transmembrane helix predicted for ROD29301 by TMHMM2.0 at aa 7-26 637910014682 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 637910014683 1 transmembrane helix predicted for ROD29311 by TMHMM2.0 at aa 146-163 637910014684 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 637910014685 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637910014686 HMMPfam hit to PF00563, EAL, score 3.3e-93 637910014687 2 transmembrane helices predicted for ROD29321 by TMHMM2.0 at aa 7-29 and 224-246 637910014688 1 transmembrane helix predicted for ROD29331 by TMHMM2.0 at aa 7-26 637910014689 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 637910014690 1 transmembrane helix predicted for ROD29341 by TMHMM2.0 at aa 143-165 637910014691 pseudogene, truncated by premature stop codon 637910014692 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 2.1e-15 637910014693 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 637910014694 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637910014695 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637910014696 1 transmembrane helix predicted for ROD29371 by TMHMM2.0 at aa 12-34 637910014697 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 2.2e-40 637910014698 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 2.9e-07 637910014699 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 637910014700 PapC N-terminal domain; Region: PapC_N; pfam13954 637910014701 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637910014702 PapC C-terminal domain; Region: PapC_C; pfam13953 637910014703 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 9.6e-238 637910014704 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 637910014705 PS00687 Aldehyde dehydrogenases glutamic acid active site. 637910014706 Fimbrial protein; Region: Fimbrial; cl01416 637910014707 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637910014708 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637910014709 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637910014710 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637910014711 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637910014712 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637910014713 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 637910014714 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 637910014715 putative active site [active] 637910014716 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.00097 637910014717 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.05 637910014718 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 2.9e-06 637910014719 PS00017 ATP/GTP-binding site motif A (P-loop). 637910014720 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.48 637910014721 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 1.5 637910014722 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.012 637910014723 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.39 637910014724 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.00023 637910014725 PS00017 ATP/GTP-binding site motif A (P-loop). 637910014726 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.041 637910014727 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.00016 637910014728 PS00017 ATP/GTP-binding site motif A (P-loop). 637910014729 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 1.4 637910014730 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.00022 637910014731 PS00017 ATP/GTP-binding site motif A (P-loop). 637910014732 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.049 637910014733 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.0015 637910014734 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.0005 637910014735 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 637910014736 HMMPfam hit to PF08845, Protein of unknown function DUF1813, HSP20-like, score 1.7e-09 637910014737 pseudogene, N- and C-termini missing, also truncated by frameshift mutation 637910014738 pseudogene, C-terminus missing, truncated by IS102 insertion 637910014739 CR_GI8 637910014740 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 637910014741 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910014742 HMMPfam hit to PF01609, Transposase, IS4-like, score 9.3e-30 637910014743 transcriptional regulator TraR; Provisional; Region: PRK13870 637910014744 Autoinducer binding domain; Region: Autoind_bind; pfam03472 637910014745 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910014746 DNA binding residues [nucleotide binding] 637910014747 dimerization interface [polypeptide binding]; other site 637910014748 HMMPfam hit to PF03472, Autoinducer-binding, score 2.2e-21 637910014749 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 2e-17 637910014750 PS00622 Bacterial regulatory proteins, luxR family signature. 637910014751 Predicted helix-turn-helix motif with score 1130.000, SD 3.04 at aa 183-204, sequence KTYAEVSLILSITERTVKFHMS 637910014752 Autoinducer synthetase; Region: Autoind_synth; cl17404 637910014753 HMMPfam hit to PF00765, Autoinducer synthesis protein, score 5.9e-65 637910014754 PS00949 Autoinducers synthetases family signature. 637910014755 PS00237 G-protein coupled receptors signature. 637910014756 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 637910014757 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 637910014758 PS00237 G-protein coupled receptors signature. 637910014759 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910014760 1 transmembrane helix predicted for ROD29561 by TMHMM2.0 at aa 93-115 637910014761 GA module; Region: GA; smart00844 637910014762 GA module; Region: GA; pfam01468 637910014763 GA module; Region: GA; smart00844 637910014764 GA module; Region: GA; pfam01468 637910014765 GA module; Region: GA; pfam01468 637910014766 GA module; Region: GA; smart00844 637910014767 GA module; Region: GA; cl08325 637910014768 GA module; Region: GA; pfam01468 637910014769 GA module; Region: GA; pfam01468 637910014770 GA module; Region: GA; pfam01468 637910014771 HMMPfam hit to PF01468, Protein G-related, albumin-binding GA module, score 7.4e-09 637910014772 HMMPfam hit to PF01468, Protein G-related, albumin-binding GA module, score 5.4e-09 637910014773 HMMPfam hit to PF01468, Protein G-related, albumin-binding GA module, score 5.8e-07 637910014774 HMMPfam hit to PF01468, Protein G-related, albumin-binding GA module, score 2e-05 637910014775 HMMPfam hit to PF01468, Protein G-related, albumin-binding GA module, score 5.5e-06 637910014776 HMMPfam hit to PF01468, Protein G-related, albumin-binding GA module, score 1.8e-07 637910014777 HMMPfam hit to PF01468, Protein G-related, albumin-binding GA module, score 7.9e-07 637910014778 HMMPfam hit to PF01468, Protein G-related, albumin-binding GA module, score 1.7e-07 637910014779 HMMPfam hit to PF01468, Protein G-related, albumin-binding GA module, score 7.1e-08 637910014780 HMMPfam hit to PF01468, Protein G-related, albumin-binding GA module, score 9.8e-07 637910014781 HMMPfam hit to PF01468, Protein G-related, albumin-binding GA module, score 2.5e-08 637910014782 HMMPfam hit to PF01468, Protein G-related, albumin-binding GA module, score 2.5e-07 637910014783 6 transmembrane helices predicted for ROD29581 by TMHMM2.0 at aa 1017-1039, 1052-1074, 1105-1127, 1134-1156, 1160-1182 and 1184-1206 637910014784 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 637910014785 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.2e-19 637910014786 HMMPfam hit to PF02321, Outer membrane efflux protein, score 8.4e-16 637910014787 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 637910014788 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637910014789 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 637910014790 Walker A/P-loop; other site 637910014791 ATP binding site [chemical binding]; other site 637910014792 Q-loop/lid; other site 637910014793 ABC transporter signature motif; other site 637910014794 Walker B; other site 637910014795 D-loop; other site 637910014796 H-loop/switch region; other site 637910014797 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 4.7e-07 637910014798 3 transmembrane helices predicted for ROD29601 by TMHMM2.0 at aa 169-191, 206-228 and 292-314 637910014799 HMMPfam hit to PF00005, ABC transporter related, score 1.9e-53 637910014800 PS00017 ATP/GTP-binding site motif A (P-loop). 637910014801 PS00017 ATP/GTP-binding site motif A (P-loop). 637910014802 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 637910014803 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637910014804 HlyD family secretion protein; Region: HlyD_3; pfam13437 637910014805 1 transmembrane helix predicted for ROD29611 by TMHMM2.0 at aa 55-77 637910014806 HMMPfam hit to PF00529, Secretion protein HlyD, score 5.6e-15 637910014807 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 637910014808 PS00543 HlyD family secretion proteins signature. 637910014809 pseudogene, N-terminal deleted by ISEc14 insertion, C-terminal part fragmented by three frameshift mutations 637910014810 HMMPfam hit to PF00665, Integrase, catalytic core, score 5.6e-21 637910014811 LEE 637910014812 putative transposase OrfB; Reviewed; Region: PHA02517 637910014813 HTH-like domain; Region: HTH_21; pfam13276 637910014814 Integrase core domain; Region: rve; pfam00665 637910014815 Integrase core domain; Region: rve_3; pfam13683 637910014816 HMMPfam hit to PF00665, Integrase, catalytic core, score 1.3e-45 637910014817 PS00501 Signal peptidases I serine active site. 637910014818 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910014819 Transposase; Region: HTH_Tnp_1; pfam01527 637910014820 HMMPfam hit to PF01527, Transposase IS3/IS911, score 5.2e-23 637910014821 Predicted helix-turn-helix motif with score 1681.000, SD 4.91 at aa 23-44, sequence YSVAEVSDRLGVSAHSLYKWLR 637910014822 EspG protein; Region: EspG; pfam06872 637910014823 HMMPfam hit to PF06872, EspG, score 0 637910014824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 637910014825 SdiA-regulated; Region: SdiA-regulated; cd09971 637910014826 putative active site [active] 637910014827 1 transmembrane helix predicted for ROD29691 by TMHMM2.0 at aa 7-29 637910014828 HMMPfam hit to PF06977, SdiA-regulated, score 9.5e-41 637910014829 DNA topoisomerase 2; Provisional; Region: PLN03237 637910014830 HMMPfam hit to PF04806, EspF protein, score 1.4e-14 637910014831 HMMPfam hit to PF04806, EspF protein, score 1.7e-94 637910014832 type III secretion system protein, SsaH family; Region: type_III_ssaH; TIGR02498 637910014833 HMMPfam hit to PF06287, type III secretion system SsaH, score 2.4e-71 637910014834 Type III secretion needle MxiH like; Region: MxiH; cl09641 637910014835 Type III secretion system regulator (LcrR); Region: LcrR; cl09838 637910014836 Enterobacterial EspB protein; Region: EspB; pfam05802 637910014837 HMMPfam hit to PF05802, Enterobacterial EspB, score 6.3e-206 637910014838 1 transmembrane helix predicted for ROD29741 by TMHMM2.0 at aa 97-119 637910014839 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 637910014840 HMMPfam hit to PF04888, Secretion system effector C (SseC) like protein, score 7.4e-157 637910014841 2 transmembrane helices predicted for ROD29751 by TMHMM2.0 at aa 181-203 and 230-252 637910014842 EspA-like secreted protein; Region: EspA; pfam03433 637910014843 HMMPfam hit to PF03433, EspA-like secreted protein, score 1e-106 637910014844 HrpJ-like domain; Region: HrpJ; cl15454 637910014845 type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511 637910014846 HMMPfam hit to PF07018, SepL/SsaL, score 1.2e-245 637910014847 type III secretion system protein SsaD; Provisional; Region: PRK15367 637910014848 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 637910014849 1 transmembrane helix predicted for ROD29781 by TMHMM2.0 at aa 120-142 637910014850 pseudogene, fragmented by five frameshift mutations and two premature stop codons 637910014851 HMMPfam hit to PF00872, Transposase, mutator type, score 5e-50 637910014852 HMMPfam hit to PF00872, Transposase, mutator type, score 1.7e-12 637910014853 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 637910014854 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 637910014855 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 637910014856 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 637910014857 Intimin C-type lectin domain; Region: Intimin_C; pfam07979 637910014858 HMMPfam hit to PF07979, Intimin, C-terminal, score 5.1e-63 637910014859 HMMPfam hit to PF02368, Bacterial Ig-like, group 2, score 6.2e-27 637910014860 HMMPfam hit to PF02369, Bacterial Ig-like, group 1, score 2.4e-35 637910014861 HMMPfam hit to PF02369, Bacterial Ig-like, group 1, score 2.2e-27 637910014862 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 0.00052 637910014863 1 transmembrane helix predicted for ROD29831 by TMHMM2.0 at aa 20-39 637910014864 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 637910014865 HMMPfam hit to PF05932, Tir chaperone, score 4.9e-38 637910014866 Translocated intimin receptor (Tir) N-terminus; Region: Tir_receptor_N; pfam07490 637910014867 Translocated intimin receptor (Tir) intimin-binding domain; Region: Tir_receptor_M; pfam03549 637910014868 Translocated intimin receptor (Tir) C-terminus; Region: Tir_receptor_C; pfam07489 637910014869 HMMPfam hit to PF07489, Translocated intimin receptor, score 1.1e-164 637910014870 HMMPfam hit to PF03549, Translocated intimin receptor, score 4e-43 637910014871 HMMPfam hit to PF07490, Translocated intimin receptor, score 1.9e-168 637910014872 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 637910014873 HMMPfam hit to PF03278, IpaB/EvcA, score 8.5e-86 637910014874 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 637910014875 SepQ protein; Region: SepQ; pfam06622 637910014876 HMMPfam hit to PF06622, SepQ, score 4.9e-273 637910014877 Protein of unknown function (DUF1106); Region: DUF1106; pfam06523 637910014878 HMMPfam hit to PF06523, Protein of unknown function DUF1106, score 3.5e-75 637910014879 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 637910014880 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 637910014881 Walker A motif/ATP binding site; other site 637910014882 Walker B motif; other site 637910014883 HMMPfam hit to PF00006, ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding, score 4.1e-121 637910014884 PS00152 ATP synthase alpha and beta subunits signature. 637910014885 PS00017 ATP/GTP-binding site motif A (P-loop). 637910014886 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 637910014887 FHIPEP family; Region: FHIPEP; pfam00771 637910014888 HMMPfam hit to PF00771, Bacterial type III secretion FHIPEP, score 0 637910014889 7 transmembrane helices predicted for ROD29941 by TMHMM2.0 at aa 13-32, 37-59, 71-93, 108-130, 199-221, 236-258 and 286-319 637910014890 PS00994 Bacterial export FHIPEP family signature. 637910014891 Region: SepZ; pfam06066 637910014892 HMMPfam hit to PF06066, SepZ, score 4.8e-62 637910014893 2 transmembrane helices predicted for ROD29961 by TMHMM2.0 at aa 42-64 and 76-97 637910014894 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 637910014895 HMMPfam hit to PF01514, Secretory protein YscJ/FliF, score 5.9e-83 637910014896 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910014897 outer membrane secretin SsaC; Provisional; Region: PRK15346 637910014898 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 637910014899 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 637910014900 HMMPfam hit to PF03958, NolW-like, score 1.8e-10 637910014901 HMMPfam hit to PF03958, NolW-like, score 4.9e-18 637910014902 HMMPfam hit to PF00263, Bacterial type II and III secretion system protein, score 6.1e-74 637910014903 PS00875 Bacterial type II secretion system protein D signature. 637910014904 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 637910014905 Tetratricopeptide repeat; Region: TPR_3; pfam07720 637910014906 HMMPfam hit to PF07720, Tetratricopeptide TPR-3, score 1.1e-11 637910014907 pseudogene, fragmented by six frameshift mutations and a premature stop codon 637910014908 HMMPfam hit to PF00665, Integrase, catalytic core, score 0.0001 637910014909 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 637910014910 HMMPfam hit to PF07180, Protein of unknown function DUF1401, score 8.4e-96 637910014911 Predicted helix-turn-helix motif with score 1217.000, SD 3.33 at aa 37-58, sequence ISRNDIAEAFGINLRRASFIIT 637910014912 negative regulator GrlR; Provisional; Region: PRK14051 637910014913 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 637910014914 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637910014915 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637910014916 catalytic residue [active] 637910014917 HMMPfam hit to PF01464, Lytic transglycosylase-like, catalytic, score 4e-40 637910014918 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 637910014919 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 637910014920 HMMPfam hit to PF01312, type III secretion exporter, score 7.2e-108 637910014921 4 transmembrane helices predicted for ROD30081 by TMHMM2.0 at aa 34-56, 89-111, 143-165 and 175-197 637910014922 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 637910014923 HMMPfam hit to PF01311, type III secretion system inner membrane R protein, score 1.8e-42 637910014924 5 transmembrane helices predicted for ROD30091 by TMHMM2.0 at aa 7-29, 78-100, 120-142, 181-203 and 210-232 637910014925 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 637910014926 HMMPfam hit to PF01313, Bacterial export protein FliQ, family 3, score 4.1e-26 637910014927 2 transmembrane helices predicted for ROD30092 by TMHMM2.0 at aa 15-37 and 49-71 637910014928 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 637910014929 4 transmembrane helices predicted for ROD30101 by TMHMM2.0 at aa 13-35, 57-79, 160-182 and 197-216 637910014930 HMMPfam hit to PF00813, type III secretion system inner membrane P protein, score 1.4e-89 637910014931 PS01061 Flagella transport protein fliP family signature 2. 637910014932 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 637910014933 Type III secretion system filament chaperone CesA; Region: CesA; pfam11439 637910014934 type III secretion system protein, YseE family; Region: type_III_yscE; TIGR02501 637910014935 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 637910014936 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 637910014937 HMMPfam hit to PF00816, Histone-like nucleoid-structuring protein H-NS, score 1.2e-32 637910014938 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910014939 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910014940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910014941 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910014942 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910014943 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910014944 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910014945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910014946 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910014947 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910014948 Transposase; Region: HTH_Tnp_1; pfam01527 637910014949 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910014950 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910014951 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910014952 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637910014953 non-specific DNA binding site [nucleotide binding]; other site 637910014954 salt bridge; other site 637910014955 sequence-specific DNA binding site [nucleotide binding]; other site 637910014956 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 2.9e-09 637910014957 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 637910014958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 637910014959 HMMPfam hit to PF04287, Protein of unknown function DUF446, score 2.2e-56 637910014960 pseudogene, truncated by premature stop codon 637910014961 HMMPfam hit to PF00849, Pseudouridine synthase, score 2.3e-53 637910014962 flavodoxin; Provisional; Region: PRK08105 637910014963 HMMPfam hit to PF00258, Flavodoxin/nitric oxide synthase, score 9e-37 637910014964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910014965 D-galactonate transporter; Region: 2A0114; TIGR00893 637910014966 putative substrate translocation pore; other site 637910014967 12 transmembrane helices predicted for ROD30251 by TMHMM2.0 at aa 20-42, 57-79, 86-105, 110-132, 152-174, 179-201, 256-278, 293-315, 328-348, 352-374, 387-409 and 414-436 637910014968 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.4e-64 637910014969 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 637910014970 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 637910014971 active site 637910014972 tetramer interface [polypeptide binding]; other site 637910014973 HMMPfam hit to PF02746, Mandelate racemase/muconate lactonizing enzyme, N-terminal, score 0.00053 637910014974 PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 637910014975 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 3.7e-25 637910014976 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 637910014977 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 637910014978 active site 637910014979 tetramer interface [polypeptide binding]; other site 637910014980 HMMPfam hit to PF02746, Mandelate racemase/muconate lactonizing enzyme, N-terminal, score 7.2e-05 637910014981 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 1.4e-22 637910014982 PS00294 Prenyl group binding site (CAAX box). 637910014983 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 637910014984 HMMPfam hit to PF02595, Glycerate kinase, score 2.6e-237 637910014985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637910014986 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637910014987 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637910014988 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 1.2e-17 637910014989 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.2e-27 637910014990 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 637910014991 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 637910014992 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637910014993 dimerization interface [polypeptide binding]; other site 637910014994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637910014995 dimer interface [polypeptide binding]; other site 637910014996 phosphorylation site [posttranslational modification] 637910014997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910014998 ATP binding site [chemical binding]; other site 637910014999 Mg2+ binding site [ion binding]; other site 637910015000 G-X-G motif; other site 637910015001 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 637910015002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910015003 active site 637910015004 phosphorylation site [posttranslational modification] 637910015005 intermolecular recognition site; other site 637910015006 dimerization interface [polypeptide binding]; other site 637910015007 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 637910015008 putative binding surface; other site 637910015009 active site 637910015010 HMMPfam hit to PF01627, Hpt, score 3.9e-16 637910015011 HMMPfam hit to PF00072, Response regulator receiver, score 6.9e-45 637910015012 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.1e-42 637910015013 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.4e-26 637910015014 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 1.5e-13 637910015015 2 transmembrane helices predicted for ROD30301 by TMHMM2.0 at aa 10-32 and 177-199 637910015016 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 637910015017 TRAM domain; Region: TRAM; pfam01938 637910015018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910015019 S-adenosylmethionine binding site [chemical binding]; other site 637910015020 HMMPfam hit to PF01938, Deoxyribonuclease/rho motif-related TRAM, score 2.6e-15 637910015021 HMMPfam hit to PF05958, (Uracil-5)-methyltransferase, score 2.5e-09 637910015022 PS01230 RNA methyltransferase trmA family signature 1. 637910015023 PS01231 RNA methyltransferase trmA family signature 2. 637910015024 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 637910015025 HD domain; Region: HD_4; pfam13328 637910015026 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 637910015027 synthetase active site [active] 637910015028 NTP binding site [chemical binding]; other site 637910015029 metal binding site [ion binding]; metal-binding site 637910015030 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 637910015031 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 637910015032 HMMPfam hit to PF04607, RelA/SpoT, score 9.7e-48 637910015033 HMMPfam hit to PF02824, TGS, score 1.7e-30 637910015034 HMMPfam hit to PF01842, Amino acid-binding ACT, score 4.8e-10 637910015035 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 637910015036 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 637910015037 homodimer interface [polypeptide binding]; other site 637910015038 metal binding site [ion binding]; metal-binding site 637910015039 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 637910015040 homodimer interface [polypeptide binding]; other site 637910015041 active site 637910015042 putative chemical substrate binding site [chemical binding]; other site 637910015043 metal binding site [ion binding]; metal-binding site 637910015044 HMMPfam hit to PF03819, NTP pyrophosphohydrolase MazG, catalytic core, score 8.8e-42 637910015045 HMMPfam hit to PF03819, NTP pyrophosphohydrolase MazG, catalytic core, score 1.5e-05 637910015046 CTP synthetase; Validated; Region: pyrG; PRK05380 637910015047 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 637910015048 Catalytic site [active] 637910015049 active site 637910015050 UTP binding site [chemical binding]; other site 637910015051 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 637910015052 active site 637910015053 putative oxyanion hole; other site 637910015054 catalytic triad [active] 637910015055 HMMPfam hit to PF06418, CTP synthase, score 4.7e-214 637910015056 1 transmembrane helix predicted for ROD30341 by TMHMM2.0 at aa 7-29 637910015057 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 5.6e-80 637910015058 PS00442 Glutamine amidotransferases class-I active site. 637910015059 enolase; Provisional; Region: eno; PRK00077 637910015060 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 637910015061 dimer interface [polypeptide binding]; other site 637910015062 metal binding site [ion binding]; metal-binding site 637910015063 substrate binding pocket [chemical binding]; other site 637910015064 HMMPfam hit to PF03952, Enolase, score 7e-70 637910015065 HMMPfam hit to PF00113, Enolase, score 2.5e-190 637910015066 PS00164 Enolase signature. 637910015067 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 637910015068 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 637910015069 HMMPfam hit to PF04055, Radical SAM, score 0.017 637910015070 Major Facilitator Superfamily; Region: MFS_1; pfam07690 637910015071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910015072 putative substrate translocation pore; other site 637910015073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910015074 putative substrate translocation pore; other site 637910015075 14 transmembrane helices predicted for ROD30381 by TMHMM2.0 at aa 21-43, 53-75, 82-104, 108-130, 143-165, 169-191, 204-223, 233-255, 276-298, 303-325, 337-359, 363-382, 410-432 and 436-458 637910015076 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 2.3e-45 637910015077 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015078 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015079 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015080 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 637910015081 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 637910015082 metal binding site [ion binding]; metal-binding site 637910015083 putative dimer interface [polypeptide binding]; other site 637910015084 HMMPfam hit to PF01546, Peptidase M20, score 3.2e-61 637910015085 HMMPfam hit to PF07687, Peptidase M20, dimerisation, score 3.3e-10 637910015086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910015087 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637910015088 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 637910015089 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 3.8e-09 637910015090 Predicted helix-turn-helix motif with score 1853.000, SD 5.50 at aa 181-202, sequence ISLAEIAQAEFVSEAWLSRLFR 637910015091 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 9e-06 637910015092 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 637910015093 active site 637910015094 HMMPfam hit to PF01242, 6-pyruvoyl tetrahydropterin synthase and hypothetical protein, score 1.1e-78 637910015095 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 637910015096 Flavodoxin; Region: Flavodoxin_1; pfam00258 637910015097 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 637910015098 FAD binding pocket [chemical binding]; other site 637910015099 FAD binding motif [chemical binding]; other site 637910015100 catalytic residues [active] 637910015101 NAD binding pocket [chemical binding]; other site 637910015102 phosphate binding motif [ion binding]; other site 637910015103 beta-alpha-beta structure motif; other site 637910015104 HMMPfam hit to PF00258, Flavodoxin/nitric oxide synthase, score 3.8e-43 637910015105 HMMPfam hit to PF00667, FAD-binding, score 2.7e-75 637910015106 HMMPfam hit to PF00175, Oxidoreductase FAD/NAD(P)-binding, score 8.3e-38 637910015107 sulfite reductase subunit beta; Provisional; Region: PRK13504 637910015108 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 637910015109 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 637910015110 HMMPfam hit to PF03460, Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like, score 5e-19 637910015111 HMMPfam hit to PF01077, Nitrite and sulphite reductase 4Fe-4S region, score 1.3e-58 637910015112 HMMPfam hit to PF03460, Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like, score 1.1e-19 637910015113 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 637910015114 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 637910015115 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 637910015116 Active Sites [active] 637910015117 HMMPfam hit to PF01507, Phosphoadenosine phosphosulphate reductase, score 2.5e-86 637910015118 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 637910015119 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 637910015120 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 637910015121 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 0.0032 637910015122 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 637910015123 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 637910015124 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 637910015125 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 637910015126 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 637910015127 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 637910015128 HMMPfam hit to PF08798, CRISPR-associated protein, CT1974, score 1.2e-89 637910015129 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 637910015130 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015131 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 637910015132 3 transmembrane helices predicted for ROD30541 by TMHMM2.0 at aa 31-50, 62-81 and 91-113 637910015133 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 637910015134 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 637910015135 metal binding site [ion binding]; metal-binding site 637910015136 HMMPfam hit to PF04389, Peptidase M28, score 4.3e-35 637910015137 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 637910015138 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 637910015139 Active Sites [active] 637910015140 HMMPfam hit to PF01507, Phosphoadenosine phosphosulphate reductase, score 1.8e-144 637910015141 PS00215 Mitochondrial energy transfer proteins signature. 637910015142 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 637910015143 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 637910015144 CysD dimerization site [polypeptide binding]; other site 637910015145 G1 box; other site 637910015146 putative GEF interaction site [polypeptide binding]; other site 637910015147 GTP/Mg2+ binding site [chemical binding]; other site 637910015148 Switch I region; other site 637910015149 G2 box; other site 637910015150 G3 box; other site 637910015151 Switch II region; other site 637910015152 G4 box; other site 637910015153 G5 box; other site 637910015154 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 637910015155 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 637910015156 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 9.6e-74 637910015157 PS00017 ATP/GTP-binding site motif A (P-loop). 637910015158 PS00301 GTP-binding elongation factors signature. 637910015159 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 2.9e-11 637910015160 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 637910015161 ligand-binding site [chemical binding]; other site 637910015162 HMMPfam hit to PF01583, Adenylylsulphate kinase, C-terminal, score 2.7e-112 637910015163 PS00017 ATP/GTP-binding site motif A (P-loop). 637910015164 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 637910015165 3 transmembrane helices predicted for ROD30601 by TMHMM2.0 at aa 23-45, 52-74 and 84-106 637910015166 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 637910015167 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 637910015168 1 transmembrane helix predicted for ROD30611 by TMHMM2.0 at aa 4-21 637910015169 HMMPfam hit to PF04977, Septum formation initiator, score 1e-34 637910015170 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 637910015171 substrate binding site; other site 637910015172 dimer interface; other site 637910015173 HMMPfam hit to PF01128, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, score 4.3e-140 637910015174 PS01295 Uncharacterized protein family UPF0007 signature. 637910015175 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 637910015176 homotrimer interaction site [polypeptide binding]; other site 637910015177 zinc binding site [ion binding]; other site 637910015178 CDP-binding sites; other site 637910015179 HMMPfam hit to PF02542, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, core, score 8e-103 637910015180 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 637910015181 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 637910015182 Permutation of conserved domain; other site 637910015183 active site 637910015184 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 637910015185 HMMPfam hit to PF01142, tRNA pseudouridine synthase D, score 1.2e-159 637910015186 PS01268 Uncharacterized protein family UPF0024 signature. 637910015187 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 637910015188 HMMPfam hit to PF01975, Survival protein SurE, score 9.4e-112 637910015189 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 637910015190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910015191 S-adenosylmethionine binding site [chemical binding]; other site 637910015192 HMMPfam hit to PF01135, Protein-L-isoaspartate(D-aspartate) O-methyltransferase, score 2.2e-125 637910015193 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910015194 PS01279 Protein-L-isoaspartate(D-aspartate) O-methyltransferase signature. 637910015195 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 637910015196 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637910015197 Peptidase family M23; Region: Peptidase_M23; pfam01551 637910015198 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015199 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 2.4e-13 637910015200 HMMPfam hit to PF01551, Peptidase M23B, score 2.4e-53 637910015201 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 637910015202 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 637910015203 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637910015204 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 637910015205 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637910015206 DNA binding residues [nucleotide binding] 637910015207 HMMPfam hit to PF00140, RNA polymerase sigma-70 region 1.2, score 3.1e-13 637910015208 HMMPfam hit to PF04542, RNA polymerase sigma-70 region 2, score 5.2e-27 637910015209 PS00715 Sigma-70 factors family signature 1. 637910015210 HMMPfam hit to PF04539, RNA polymerase sigma-70 region 3, score 4.3e-28 637910015211 HMMPfam hit to PF04545, RNA polymerase sigma-70 region 4, score 1.5e-20 637910015212 Predicted helix-turn-helix motif with score 1306.000, SD 3.64 at aa 286-307, sequence ATLEDVGREIGLTRERVRQIQV 637910015213 PS00716 Sigma-70 factors family signature 2. 637910015214 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637910015215 MarR family; Region: MarR_2; cl17246 637910015216 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 1.4e-18 637910015217 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 637910015218 Flavoprotein; Region: Flavoprotein; pfam02441 637910015219 HMMPfam hit to PF02441, Flavoprotein, score 2.5e-42 637910015220 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 637910015221 HMMPfam hit to PF01977, Carboxylyase-related, score 1.8e-154 637910015222 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 637910015223 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 637910015224 MutS domain I; Region: MutS_I; pfam01624 637910015225 MutS domain II; Region: MutS_II; pfam05188 637910015226 MutS domain III; Region: MutS_III; pfam05192 637910015227 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 637910015228 Walker A/P-loop; other site 637910015229 ATP binding site [chemical binding]; other site 637910015230 Q-loop/lid; other site 637910015231 ABC transporter signature motif; other site 637910015232 Walker B; other site 637910015233 D-loop; other site 637910015234 H-loop/switch region; other site 637910015235 HMMPfam hit to PF00488, DNA mismatch repair protein MutS, C-terminal, score 1.6e-175 637910015236 PS00486 DNA mismatch repair proteins mutS family signature. 637910015237 PS00017 ATP/GTP-binding site motif A (P-loop). 637910015238 HMMPfam hit to PF05192, MutS III, score 1.3e-95 637910015239 HMMPfam hit to PF05190, MutS IV, score 1.5e-41 637910015240 HMMPfam hit to PF05188, MutS II, score 4.6e-51 637910015241 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 637910015242 HMMPfam hit to PF01624, DNA mismatch repair protein MutS, N-terminal, score 6.2e-73 637910015243 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 637910015244 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637910015245 ABC-ATPase subunit interface; other site 637910015246 dimer interface [polypeptide binding]; other site 637910015247 8 transmembrane helices predicted for ROD30751 by TMHMM2.0 at aa 21-43, 53-75, 95-114, 129-151, 171-193, 198-215, 222-244 and 248-270 637910015248 HMMPfam hit to PF00950, ABC-3, score 2.5e-104 637910015249 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 637910015250 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 637910015251 ABC-ATPase subunit interface; other site 637910015252 dimer interface [polypeptide binding]; other site 637910015253 putative PBP binding regions; other site 637910015254 7 transmembrane helices predicted for ROD30761 by TMHMM2.0 at aa 15-37, 50-72, 92-114, 127-149, 183-205, 218-240 and 250-272 637910015255 HMMPfam hit to PF00950, ABC-3, score 1.9e-109 637910015256 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015257 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 637910015258 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 637910015259 HMMPfam hit to PF00005, ABC transporter related, score 1.4e-49 637910015260 PS00211 ABC transporters family signature. 637910015261 PS00017 ATP/GTP-binding site motif A (P-loop). 637910015262 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 637910015263 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 637910015264 metal binding site [ion binding]; metal-binding site 637910015265 HMMPfam hit to PF01297, Periplasmic solute binding protein, score 2.4e-119 637910015266 1 transmembrane helix predicted for ROD30781 by TMHMM2.0 at aa 7-26 637910015267 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 637910015268 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 637910015269 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 637910015270 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 637910015271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910015272 Walker A motif; other site 637910015273 ATP binding site [chemical binding]; other site 637910015274 Walker B motif; other site 637910015275 arginine finger; other site 637910015276 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 637910015277 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 2.5e-06 637910015278 PS00688 Sigma-54 interaction domain C-terminal part signature. 637910015279 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 3.8e-147 637910015280 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 637910015281 HMMPfam hit to PF01590, GAF, score 6.4e-18 637910015282 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 637910015283 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 637910015284 dimerization interface [polypeptide binding]; other site 637910015285 ATP binding site [chemical binding]; other site 637910015286 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 3.2e-36 637910015287 HMMPfam hit to PF00586, AIR synthase related protein, score 2.4e-32 637910015288 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 637910015289 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 637910015290 HMMPfam hit to PF01924, Hydrogenase formation HypD protein, score 9.7e-262 637910015291 hydrogenase assembly chaperone; Provisional; Region: PRK10409 637910015292 HMMPfam hit to PF01455, Hydrogenase expression/formation protein (HUPF/HYPC), score 2.1e-44 637910015293 PS01097 Hydrogenases expression/synthesis hupF/hypC family signature. 637910015294 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 637910015295 HMMPfam hit to PF02492, Cobalamin (vitamin B12) biosynthesis CobW-like, score 1.3e-69 637910015296 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 637910015297 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 637910015298 HMMPfam hit to PF01155, Hydrogenase expression/synthesis, HypA, score 2e-54 637910015299 PS01249 Hydrogenases expression/synthesis hypA family signature. 637910015300 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 637910015301 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 637910015302 PS00190 Cytochrome c family heme-binding site signature. 637910015303 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 4.5e-07 637910015304 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910015305 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 637910015306 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 637910015307 15 transmembrane helices predicted for ROD30881 by TMHMM2.0 at aa 4-26, 31-53, 73-95, 108-125, 129-148, 155-177, 197-219, 231-253, 257-279, 292-311, 326-348, 373-395, 415-437, 457-479 and 499-521 637910015308 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015309 HMMPfam hit to PF00361, NADH/Ubiquinone/plastoquinone (complex I), score 5.1e-30 637910015310 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015311 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 637910015312 NADH dehydrogenase; Region: NADHdh; cl00469 637910015313 HMMPfam hit to PF00146, Respiratory-chain NADH dehydrogenase, subunit 1, score 5e-06 637910015314 7 transmembrane helices predicted for ROD30891 by TMHMM2.0 at aa 5-27, 62-84, 94-111, 132-154, 169-188, 252-274 and 289-306 637910015315 PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. 637910015316 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015317 PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 637910015318 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 637910015319 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 637910015320 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 637910015321 HMMPfam hit to PF00329, NADH dehydrogenase (ubiquinone), 30 kDa subunit, score 1.1e-27 637910015322 PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 637910015323 HMMPfam hit to PF00374, Nickel-dependent hydrogenase, large subunit, score 5.9e-11 637910015324 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015325 HMMPfam hit to PF00346, NADH-ubiquinone oxidoreductase, chain 49kDa, score 2.9e-13 637910015326 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 637910015327 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637910015328 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 2.1e-07 637910015329 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910015330 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 2.1e-08 637910015331 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910015332 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 637910015333 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 kDa subunit, score 1.2e-52 637910015334 PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. 637910015335 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 637910015336 HMMPfam hit to PF07450, Formate hydrogenlyase maturation HycH, score 2.9e-99 637910015337 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 637910015338 nickel binding site [ion binding]; other site 637910015339 HMMPfam hit to PF01750, Peptidase A31, hydrogen uptake protein, score 8.2e-35 637910015340 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 637910015341 HMMPfam hit to PF04014, SpoVT/AbrB-like, predicted transcription regulator, score 0.0017 637910015342 PemK-like protein; Region: PemK; pfam02452 637910015343 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 637910015344 HMMPfam hit to PF08845, Protein of unknown function DUF1813, HSP20-like, score 1e-18 637910015345 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 637910015346 beta-galactosidase; Region: BGL; TIGR03356 637910015347 HMMPfam hit to PF00232, Glycoside hydrolase, family 1, score 6.9e-145 637910015348 PS00572 Glycosyl hydrolases family 1 active site. 637910015349 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 637910015350 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 637910015351 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637910015352 active site turn [active] 637910015353 phosphorylation site [posttranslational modification] 637910015354 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 637910015355 8 transmembrane helices predicted for ROD30991 by TMHMM2.0 at aa 102-124, 149-171, 178-197, 212-234, 255-277, 282-304, 389-411 and 431-453 637910015356 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.3e-56 637910015357 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 4.6e-19 637910015358 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 637910015359 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637910015360 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910015361 DNA binding site [nucleotide binding] 637910015362 domain linker motif; other site 637910015363 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 637910015364 dimerization interface (closed form) [polypeptide binding]; other site 637910015365 ligand binding site [chemical binding]; other site 637910015366 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 9.4e-13 637910015367 Predicted helix-turn-helix motif with score 1940.000, SD 5.79 at aa 2-23, sequence TTMLEVAKRAGVSKATVSRVLS 637910015368 PS00356 Bacterial regulatory proteins, lacI family signature. 637910015369 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 5.2e-09 637910015370 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 637910015371 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 637910015372 Predicted helix-turn-helix motif with score 983.000, SD 2.53 at aa 41-62, sequence LPRIHVIKGVNVSTATLCRQCE 637910015373 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 7.5e-08 637910015374 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910015375 PS00190 Cytochrome c family heme-binding site signature. 637910015376 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 637910015377 Acylphosphatase; Region: Acylphosphatase; pfam00708 637910015378 HypF finger; Region: zf-HYPF; pfam07503 637910015379 HypF finger; Region: zf-HYPF; pfam07503 637910015380 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 637910015381 HMMPfam hit to PF00708, Acylphosphatase, score 1.4e-06 637910015382 PS00150 Acylphosphatase signature 1. 637910015383 HMMPfam hit to PF07503, Zinc finger, HypF-type, score 1.3e-16 637910015384 HMMPfam hit to PF07503, Zinc finger, HypF-type, score 1.7e-14 637910015385 HMMPfam hit to PF01300, SUA5/yciO/yrdC, N-terminal, score 4.1e-66 637910015386 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 637910015387 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637910015388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637910015389 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 3.2e-26 637910015390 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 2.6e-29 637910015391 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 637910015392 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 637910015393 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 637910015394 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 637910015395 iron binding site [ion binding]; other site 637910015396 HMMPfam hit to PF00301, Rubredoxin-type Fe(Cys)4 protein, score 6.2e-23 637910015397 HMMPfam hit to PF00258, Flavodoxin/nitric oxide synthase, score 2.2e-24 637910015398 HMMPfam hit to PF00753, beta-lactamase-like, score 4.4e-30 637910015399 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 637910015400 GAF domain; Region: GAF; pfam01590 637910015401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910015402 Walker A motif; other site 637910015403 ATP binding site [chemical binding]; other site 637910015404 Walker B motif; other site 637910015405 arginine finger; other site 637910015406 HMMPfam hit to PF01590, GAF, score 4e-14 637910015407 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 1e-143 637910015408 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 637910015409 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 637910015410 PS00688 Sigma-54 interaction domain C-terminal part signature. 637910015411 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 637910015412 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 637910015413 putative active site [active] 637910015414 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 637910015415 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 6.6e-24 637910015416 PS00622 Bacterial regulatory proteins, luxR family signature. 637910015417 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 2.4e-33 637910015418 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 637910015419 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 637910015420 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637910015421 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 5.5e-82 637910015422 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 1.5e-25 637910015423 PS00894 Bacterial regulatory proteins, deoR family signature. 637910015424 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 637910015425 HMMPfam hit to PF06923, Glucitol operon activator, score 4.3e-55 637910015426 1 transmembrane helix predicted for ROD31081 by TMHMM2.0 at aa 2-24 637910015427 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 637910015428 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 637910015429 putative NAD(P) binding site [chemical binding]; other site 637910015430 active site 637910015431 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 1.6e-26 637910015432 PS00061 Short-chain dehydrogenases/reductases family signature. 637910015433 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 637910015434 HMMPfam hit to PF03829, Phosphotransferase system, glucitol/sorbitol-specific IIA component, score 2.9e-71 637910015435 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 637910015436 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 637910015437 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 637910015438 4 transmembrane helices predicted for ROD31111 by TMHMM2.0 at aa 181-203, 218-240, 247-269 and 300-322 637910015439 HMMPfam hit to PF07663, Sorbitol phosphotransferase enzyme II, C-terminal, score 2.5e-56 637910015440 PS00107 Protein kinases ATP-binding region signature. 637910015441 HMMPfam hit to PF03612, Sorbitol phosphotransferase enzyme II, N-terminal, score 1.1e-118 637910015442 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 637910015443 HMMPfam hit to PF03608, Phosphotransferase system, enzyme II sorbitol-specific factor, score 9.8e-143 637910015444 3 transmembrane helices predicted for ROD31121 by TMHMM2.0 at aa 26-48, 68-90 and 134-156 637910015445 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015446 Transglycosylase SLT domain; Region: SLT_2; pfam13406 637910015447 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637910015448 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637910015449 catalytic residue [active] 637910015450 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015451 hypothetical protein; Validated; Region: PRK03661 637910015452 HMMPfam hit to PF02464, CinA, C-terminal, score 7.5e-94 637910015453 recombinase A; Provisional; Region: recA; PRK09354 637910015454 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 637910015455 hexamer interface [polypeptide binding]; other site 637910015456 Walker A motif; other site 637910015457 ATP binding site [chemical binding]; other site 637910015458 Walker B motif; other site 637910015459 HMMPfam hit to PF00154, RecA, score 2.7e-253 637910015460 PS00017 ATP/GTP-binding site motif A (P-loop). 637910015461 PS00017 ATP/GTP-binding site motif A (P-loop). 637910015462 PS00321 recA signature. 637910015463 recombination regulator RecX; Reviewed; Region: recX; PRK00117 637910015464 HMMPfam hit to PF02631, Regulatory protein RecX, score 3e-56 637910015465 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 637910015466 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 637910015467 motif 1; other site 637910015468 active site 637910015469 motif 2; other site 637910015470 motif 3; other site 637910015471 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 637910015472 DHHA1 domain; Region: DHHA1; pfam02272 637910015473 HMMPfam hit to PF01411, Alanyl-tRNA synthetase, class IIc, score 0 637910015474 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910015475 HMMPfam hit to PF07973, Threonyl/alanyl tRNA synthetase, SAD, score 1.1e-21 637910015476 HMMPfam hit to PF02272, Phosphoesterase, DHHA1, score 4.3e-23 637910015477 carbon storage regulator; Provisional; Region: PRK01712 637910015478 HMMPfam hit to PF02599, Carbon storage regulator, score 7.2e-35 637910015479 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 637910015480 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910015481 active site 637910015482 motif I; other site 637910015483 motif II; other site 637910015484 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 5.8e-32 637910015485 Predicted membrane protein [Function unknown]; Region: COG1238 637910015486 4 transmembrane helices predicted for ROD31221 by TMHMM2.0 at aa 15-37, 44-66, 86-108 and 115-137 637910015487 glutamate--cysteine ligase; Provisional; Region: PRK02107 637910015488 HMMPfam hit to PF04262, glutamate--cysteine ligase, score 5.6e-284 637910015489 S-ribosylhomocysteinase; Provisional; Region: PRK02260 637910015490 HMMPfam hit to PF02664, S-ribosylhomocysteinase (LuxS), score 1.7e-115 637910015491 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 637910015492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910015493 putative substrate translocation pore; other site 637910015494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910015495 13 transmembrane helices predicted for ROD31251 by TMHMM2.0 at aa 9-28, 51-73, 80-102, 106-128, 140-162, 167-189, 201-218, 228-250, 270-292, 302-324, 336-353, 368-390 and 480-498 637910015496 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 3.4e-56 637910015497 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015498 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 637910015499 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637910015500 HlyD family secretion protein; Region: HlyD_3; pfam13437 637910015501 HMMPfam hit to PF00529, Secretion protein HlyD, score 5.1e-86 637910015502 1 transmembrane helix predicted for ROD31261 by TMHMM2.0 at aa 23-45 637910015503 transcriptional repressor MprA; Provisional; Region: PRK10870 637910015504 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 637910015505 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 1.8e-26 637910015506 PS01117 Bacterial regulatory proteins, marR family signature. 637910015507 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 637910015508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910015509 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 4.2e-40 637910015510 10 transmembrane helices predicted for ROD31281 by TMHMM2.0 at aa 7-29, 48-70, 77-94, 104-126, 133-155, 160-182, 217-239, 249-271, 284-306 and 338-360 637910015511 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 637910015512 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 637910015513 HMMPfam hit to PF04069, Substrate-binding region of ABC-type glycine betaine transport system, score 1.7e-58 637910015514 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 637910015515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910015516 dimer interface [polypeptide binding]; other site 637910015517 conserved gate region; other site 637910015518 putative PBP binding loops; other site 637910015519 ABC-ATPase subunit interface; other site 637910015520 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1e-33 637910015521 6 transmembrane helices predicted for ROD31301 by TMHMM2.0 at aa 92-114, 119-141, 148-170, 196-218, 271-293 and 297-319 637910015522 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910015523 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 637910015524 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 637910015525 Walker A/P-loop; other site 637910015526 ATP binding site [chemical binding]; other site 637910015527 Q-loop/lid; other site 637910015528 ABC transporter signature motif; other site 637910015529 Walker B; other site 637910015530 D-loop; other site 637910015531 H-loop/switch region; other site 637910015532 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 637910015533 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 5.7e-10 637910015534 HMMPfam hit to PF00005, ABC transporter related, score 2.1e-67 637910015535 PS00211 ABC transporters family signature. 637910015536 PS00017 ATP/GTP-binding site motif A (P-loop). 637910015537 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 637910015538 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 637910015539 dimer interface [polypeptide binding]; other site 637910015540 putative radical transfer pathway; other site 637910015541 diiron center [ion binding]; other site 637910015542 tyrosyl radical; other site 637910015543 HMMPfam hit to PF00268, Ribonucleotide reductase, score 4.2e-116 637910015544 PS00368 Ribonucleotide reductase small subunit signature. 637910015545 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 637910015546 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 637910015547 Class I ribonucleotide reductase; Region: RNR_I; cd01679 637910015548 active site 637910015549 dimer interface [polypeptide binding]; other site 637910015550 catalytic residues [active] 637910015551 effector binding site; other site 637910015552 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 637910015553 HMMPfam hit to PF02867, Ribonucleotide reductase large subunit, C-terminal, score 3e-260 637910015554 PS00089 Ribonucleotide reductase large subunit signature. 637910015555 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 637910015556 HMMPfam hit to PF00317, Ribonucleotide reductase large subunit, N-terminal, score 4.1e-25 637910015557 HMMPfam hit to PF08343, Ribonucleotide reductase N-terminal, score 7.5e-43 637910015558 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 637910015559 HMMPfam hit to PF07972, Ribonucleotide reductase Class Ib, NrdI, score 1.5e-78 637910015560 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 637910015561 catalytic residues [active] 637910015562 HMMPfam hit to PF00462, Glutaredoxin, score 2.6e-16 637910015563 PS00190 Cytochrome c family heme-binding site signature. 637910015564 hypothetical protein; Provisional; Region: PRK10132 637910015565 HMMPfam hit to PF05957, Protein of unknown function DUF883, ElaB, score 4.6e-45 637910015566 1 transmembrane helix predicted for ROD31361 by TMHMM2.0 at aa 87-106 637910015567 hypothetical protein; Provisional; Region: PRK10556 637910015568 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 637910015569 HMMPfam hit to PF06610, Protein of unknown function DUF1144, score 9.1e-100 637910015570 4 transmembrane helices predicted for ROD31381 by TMHMM2.0 at aa 12-34, 44-62, 83-105 and 110-132 637910015571 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 637910015572 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 637910015573 HMMPfam hit to PF00816, Histone-like nucleoid-structuring protein H-NS, score 1.6e-47 637910015574 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 637910015575 active site residue [active] 637910015576 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 637910015577 2 transmembrane helices predicted for ROD31401 by TMHMM2.0 at aa 113-135 and 140-162 637910015578 HMMPfam hit to PF00581, Rhodanese-like, score 1.4e-05 637910015579 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637910015580 putative DNA binding site [nucleotide binding]; other site 637910015581 dimerization interface [polypeptide binding]; other site 637910015582 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637910015583 putative Zn2+ binding site [ion binding]; other site 637910015584 HMMPfam hit to PF01022, Bacterial regulatory protein, ArsR, score 5.7e-18 637910015585 Predicted helix-turn-helix motif with score 1759.000, SD 5.18 at aa 39-60, sequence TSAGELAKITGLSPSATSQHLA 637910015586 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 637910015587 HMMPfam hit to PF01679, Protein of unknown function UPF0057, score 1.9e-23 637910015588 PS01309 Uncharacterized protein family UPF0057 signature. 637910015589 1 transmembrane helix predicted for ROD31421 by TMHMM2.0 at aa 26-48 637910015590 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 637910015591 bacterial OsmY and nodulation domain; Region: BON; smart00749 637910015592 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637910015593 HMMPfam hit to PF04972, Transport-associated, score 3.3e-10 637910015594 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 7.1e-14 637910015595 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 637910015596 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 637910015597 1 transmembrane helix predicted for ROD31441 by TMHMM2.0 at aa 13-35 637910015598 PS00120 Lipases, serine active site. 637910015599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 637910015600 12 transmembrane helices predicted for ROD31451 by TMHMM2.0 at aa 20-42, 47-69, 110-132, 142-164, 171-193, 208-230, 260-282, 321-343, 356-378, 388-410, 415-433 and 470-492 637910015601 HMMPfam hit to PF01970, Protein of unknown function DUF112, transmembrane, score 1.1e-221 637910015602 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015603 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 637910015604 4 transmembrane helices predicted for ROD31461 by TMHMM2.0 at aa 5-22, 37-55, 76-98 and 102-124 637910015605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 637910015606 HMMPfam hit to PF03401, Bordetella uptake gene, score 5.6e-08 637910015607 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 637910015608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910015609 active site 637910015610 phosphorylation site [posttranslational modification] 637910015611 intermolecular recognition site; other site 637910015612 dimerization interface [polypeptide binding]; other site 637910015613 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637910015614 DNA binding site [nucleotide binding] 637910015615 HMMPfam hit to PF00072, Response regulator receiver, score 2.8e-36 637910015616 PS00217 Sugar transport proteins signature 2. 637910015617 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 2.1e-18 637910015618 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 637910015619 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 637910015620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637910015621 dimer interface [polypeptide binding]; other site 637910015622 phosphorylation site [posttranslational modification] 637910015623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910015624 ATP binding site [chemical binding]; other site 637910015625 G-X-G motif; other site 637910015626 2 transmembrane helices predicted for ROD31491 by TMHMM2.0 at aa 15-37 and 170-192 637910015627 HMMPfam hit to PF08521, Two-component sensor kinase N-terminal, score 4.9e-71 637910015628 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 637910015629 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 6.5e-09 637910015630 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.3e-08 637910015631 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 9.7e-28 637910015632 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 637910015633 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910015634 HMMPfam hit to PF01609, Transposase, IS4-like, score 9.3e-30 637910015635 pseudogene, C-terminus deleted by IS102 insertion 637910015636 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637910015637 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910015638 DNA-binding site [nucleotide binding]; DNA binding site 637910015639 UTRA domain; Region: UTRA; pfam07702 637910015640 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 1.6e-20 637910015641 PS00043 Bacterial regulatory proteins, gntR family signature. 637910015642 Predicted helix-turn-helix motif with score 1199.000, SD 3.27 at aa 39-60, sequence PSEYQIMDMLEVSRGTVKKAVN 637910015643 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 1.2e-32 637910015644 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637910015645 active site 637910015646 phosphorylation site [posttranslational modification] 637910015647 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 2.1e-06 637910015648 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 637910015649 active site 637910015650 P-loop; other site 637910015651 phosphorylation site [posttranslational modification] 637910015652 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 2.3e-05 637910015653 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 637910015654 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 637910015655 11 transmembrane helices predicted for ROD31571 by TMHMM2.0 at aa 13-35, 42-64, 98-120, 141-163, 178-200, 224-246, 251-270, 305-327, 337-356, 363-385 and 421-443 637910015656 HMMPfam hit to PF03611, Phosphotransferase system, galactitol-specific IIC component, score 2.2e-123 637910015657 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015658 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 637910015659 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 637910015660 putative N- and C-terminal domain interface [polypeptide binding]; other site 637910015661 putative active site [active] 637910015662 putative MgATP binding site [chemical binding]; other site 637910015663 catalytic site [active] 637910015664 metal binding site [ion binding]; metal-binding site 637910015665 putative carbohydrate binding site [chemical binding]; other site 637910015666 HMMPfam hit to PF00370, Carbohydrate kinase, FGGY, score 7e-37 637910015667 HMMPfam hit to PF02782, Carbohydrate kinase, FGGY, score 3.7e-09 637910015668 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015669 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 637910015670 intersubunit interface [polypeptide binding]; other site 637910015671 active site 637910015672 zinc binding site [ion binding]; other site 637910015673 Na+ binding site [ion binding]; other site 637910015674 HMMPfam hit to PF01116, Ketose-bisphosphate aldolase, class-II, score 3.6e-49 637910015675 PS00602 Fructose-bisphosphate aldolase class-II signature 1. 637910015676 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 637910015677 dimerization domain swap beta strand [polypeptide binding]; other site 637910015678 regulatory protein interface [polypeptide binding]; other site 637910015679 active site 637910015680 regulatory phosphorylation site [posttranslational modification]; other site 637910015681 HMMPfam hit to PF00381, Phosphotransferase system, phosphocarrier HPr protein, score 3.6e-09 637910015682 PS00369 PTS HPR component histidine phosphorylation site signature. 637910015683 benzoate transport; Region: 2A0115; TIGR00895 637910015684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910015685 putative substrate translocation pore; other site 637910015686 12 transmembrane helices predicted for ROD31611 by TMHMM2.0 at aa 25-47, 62-84, 91-110, 115-137, 150-172, 177-199, 260-282, 292-314, 323-340, 344-366, 387-409 and 414-431 637910015687 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 7.6e-55 637910015688 PS00216 Sugar transport proteins signature 1. 637910015689 PS00217 Sugar transport proteins signature 2. 637910015690 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 637910015691 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 637910015692 putative active site [active] 637910015693 Fe(II) binding site [ion binding]; other site 637910015694 putative dimer interface [polypeptide binding]; other site 637910015695 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 637910015696 putative dimer interface [polypeptide binding]; other site 637910015697 putative N- and C-terminal domain interface [polypeptide binding]; other site 637910015698 HMMPfam hit to PF02900, Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B, score 2.3e-59 637910015699 HMMPfam hit to PF07746, Extradiol ring-cleavage dioxygenase LigAB, LigA subunit, score 7.2e-44 637910015700 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910015701 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910015702 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 637910015703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910015704 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 637910015705 putative dimerization interface [polypeptide binding]; other site 637910015706 HMMPfam hit to PF03466, LysR, substrate-binding, score 3.4e-39 637910015707 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 9.2e-10 637910015708 PS00044 Bacterial regulatory proteins, lysR family signature. 637910015709 Predicted helix-turn-helix motif with score 1427.000, SD 4.05 at aa 126-147, sequence NHTQTVATQLGVTQPAVSAALK 637910015710 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 4.9e-19 637910015711 PS00044 Bacterial regulatory proteins, lysR family signature. 637910015712 Predicted helix-turn-helix motif with score 1427.000, SD 4.05 at aa 25-46, sequence GSVSRAADDLFRTQSAITRAIR 637910015713 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 637910015714 HMMPfam hit to PF02585, N-acetylglucosaminylphosphatidylinositol deacetylase, score 1.1e-37 637910015715 Predicted helix-turn-helix motif with score 1257.000, SD 3.47 at aa 49-70, sequence GESAKLWRKGNMTEETVKRYRR 637910015716 hypothetical protein; Provisional; Region: PRK09262 637910015717 HMMPfam hit to PF03737, Ribonuclease E inhibitor RraA/Dimethylmenaquinone methyltransferase, score 2.9e-16 637910015718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 637910015719 HMMPfam hit to PF04303, Protein of unknown function DUF453, score 2e-148 637910015720 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015721 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 637910015722 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 637910015723 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 637910015724 HMMPfam hit to PF03446, 6-phosphogluconate dehydrogenase, NAD-binding, score 2.4e-05 637910015725 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015726 HMMPfam hit to PF09130, Phosphogluconate dehydrogenase, NAD-binding, , C-terminal, score 6.3e-29 637910015727 anti-adapter protein IraM; Provisional; Region: PRK09919 637910015728 NTP pyrophosphohydrolases including oxidative damage repair enzymes [DNA replication, recombination, and repair / General function prediction only]; Region: MutT; COG0494 637910015729 nudix motif; other site 637910015730 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 0.05 637910015731 pseudogene, N-terminus missing, C-terminal part truncated by frameshift mutation 637910015732 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 3.7e-12 637910015733 prophage remnant; CRPr33 637910015734 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 637910015735 Putative prophage tail fibre C-terminus; Region: Phage_fiber_C; pfam06820 637910015736 HMMPfam hit to PF08400, Prophage tail fibre N-terminal, score 4.5e-12 637910015737 HMMPfam hit to PF06820, prophage tail fibre, C-terminal, score 7.7e-28 637910015738 one of three copies in CR (ROD12061, ROD16501, ROD31741); pseudogene, truncated by frameshift mutation 637910015739 HMMPfam hit to PF06820, prophage tail fibre, C-terminal, score 4.5e-28 637910015740 pseudogene, truncated by premature stop codon and frameshift mutation 637910015741 HMMPfam hit to PF06416, Protein of unknown function DUF1076, score 2.2e-68 637910015742 pseudogene, fragmented by two premature stop codons and three frameshift mutations 637910015743 HMMPfam hit to PF06416, Protein of unknown function DUF1076, score 6.6e-62 637910015744 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 637910015745 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015746 HMMPfam hit to PF03278, IpaB/EvcA, score 2.2e-65 637910015747 CR_GI9 637910015748 pseudogene, truncated by frameshift mutation 637910015749 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 4.2e-45 637910015750 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145 637910015751 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 637910015752 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 637910015753 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 637910015754 pseudogene, N-terminus missing, C-terminal part fragmented by three frameshift mutations 637910015755 HMMPfam hit to PF00665, Integrase, catalytic core, score 2.5e-38 637910015756 pseudogene, truncated by two frameshift mutations and missense mutation of start codon 637910015757 pseudogene, truncated by frameshift mutation 637910015758 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 3.4e-26 637910015759 Transposase; Region: HTH_Tnp_1; pfam01527 637910015760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910015761 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910015762 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910015763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910015764 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910015765 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910015766 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910015767 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910015768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910015769 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910015770 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910015771 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910015772 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910015773 PS00063 Aldo/keto reductase family active site signature. 637910015774 pseudogene, truncated by frameshift mutation; Note, ROD20691 is an intact copy of this gene 637910015775 pseudogene, truncated by frameshift mutation and premature stop codon 637910015776 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 5.6e-21 637910015777 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 637910015778 HMMPfam hit to PF06674, Protein of unknown function DUF1176, score 1.5e-16 637910015779 putative transcriptional regulator; Provisional; Region: PRK11640 637910015780 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 637910015781 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 637910015782 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 637910015783 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 637910015784 DsbD alpha interface [polypeptide binding]; other site 637910015785 catalytic residues [active] 637910015786 HMMPfam hit to PF00085, Thioredoxin domain, score 0.0031 637910015787 PS00194 Thioredoxin family active site. 637910015788 7 transmembrane helices predicted for ROD31991 by TMHMM2.0 at aa 178-200, 212-234, 249-271, 292-314, 334-356, 369-386 and 391-413 637910015789 HMMPfam hit to PF02683, Cytochrome c biogenesis protein, transmembrane region, score 4.6e-07 637910015790 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 637910015791 HMMPfam hit to PF03091, Divalent ion tolerance protein, CutA1, score 1.5e-55 637910015792 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 637910015793 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 637910015794 10 transmembrane helices predicted for ROD32011 by TMHMM2.0 at aa 7-40, 50-72, 93-115, 162-184, 226-243, 258-277, 284-306, 326-345, 358-380 and 410-432 637910015795 HMMPfam hit to PF03605, Anaerobic c4-dicarboxylate membrane transporter score 1.7e-240 637910015796 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 637910015797 Aspartase; Region: Aspartase; cd01357 637910015798 active sites [active] 637910015799 tetramer interface [polypeptide binding]; other site 637910015800 HMMPfam hit to PF00206, Fumarate lyase, score 1e-180 637910015801 PS00163 Fumarate lyases signature. 637910015802 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 637910015803 3 transmembrane helices predicted for ROD32031 by TMHMM2.0 at aa 4-21, 26-48 and 79-101 637910015804 HMMPfam hit to PF04186, FxsA cytoplasmic membrane protein, score 3.9e-59 637910015805 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 637910015806 putative transporter; Provisional; Region: PRK11021 637910015807 11 transmembrane helices predicted for ROD32041 by TMHMM2.0 at aa 13-35, 41-63, 87-109, 114-136, 143-165, 185-207, 220-242, 265-287, 318-340, 344-366 and 373-406 637910015808 HMMPfam hit to PF00324, Amino acid permease-associated region, score 0.00093 637910015809 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015810 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015811 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 637910015812 oligomerisation interface [polypeptide binding]; other site 637910015813 mobile loop; other site 637910015814 roof hairpin; other site 637910015815 HMMPfam hit to PF00166, Chaperonin Cpn10, score 7.9e-42 637910015816 PS00681 Chaperonins cpn10 signature. 637910015817 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 637910015818 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 637910015819 ring oligomerisation interface [polypeptide binding]; other site 637910015820 ATP/Mg binding site [chemical binding]; other site 637910015821 stacking interactions; other site 637910015822 hinge regions; other site 637910015823 HMMPfam hit to PF00118, Chaperonin Cpn60/TCP-1, score 3.7e-194 637910015824 PS00296 Chaperonins cpn60 signature. 637910015825 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 637910015826 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 637910015827 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 637910015828 putative active site [active] 637910015829 putative NTP binding site [chemical binding]; other site 637910015830 putative nucleic acid binding site [nucleotide binding]; other site 637910015831 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 637910015832 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 637910015833 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 637910015834 active site 637910015835 HMMPfam hit to PF00078, RNA-directed DNA polymerase (reverse transcriptase), score 6e-57 637910015836 HMMPfam hit to PF08388, Group II intron, maturase-specific, score 9.3e-35 637910015837 HMMPfam hit to PF01844, HNH endonuclease, score 0.00029 637910015838 PS00028 Zinc finger, C2H2 type, domain. 637910015839 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 637910015840 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015841 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 637910015842 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910015843 FeS/SAM binding site; other site 637910015844 HMMPfam hit to PF04055, Radical SAM, score 3.7e-11 637910015845 elongation factor P; Validated; Region: PRK00529 637910015846 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 637910015847 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 637910015848 RNA binding site [nucleotide binding]; other site 637910015849 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 637910015850 RNA binding site [nucleotide binding]; other site 637910015851 HMMPfam hit to PF08207, Translation elongation factor, KOW-like, score 2.2e-32 637910015852 HMMPfam hit to PF01132, Translation elongation factor P/YeiP, central, score 3.2e-32 637910015853 HMMPfam hit to PF09285, Elongation factor P, C-terminal, score 4e-35 637910015854 PS01275 Elongation factor P signature. 637910015855 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637910015856 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910015857 DNA binding residues [nucleotide binding] 637910015858 dimerization interface [polypeptide binding]; other site 637910015859 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 4.9e-09 637910015860 PS00622 Bacterial regulatory proteins, luxR family signature. 637910015861 PS00017 ATP/GTP-binding site motif A (P-loop). 637910015862 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015863 multidrug efflux system protein; Provisional; Region: PRK11431 637910015864 HMMPfam hit to PF00893, Small multidrug resistance protein, score 1.3e-48 637910015865 4 transmembrane helices predicted for ROD32131 by TMHMM2.0 at aa 2-19, 29-48, 55-77 and 87-104 637910015866 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 637910015867 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 637910015868 HMMPfam hit to PF08212, Lipocalin-like, score 2.4e-77 637910015869 PS00213 Lipocalin signature. 637910015870 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015871 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 637910015872 Iron-sulfur protein interface; other site 637910015873 proximal quinone binding site [chemical binding]; other site 637910015874 C-subunit interface; other site 637910015875 distal quinone binding site; other site 637910015876 HMMPfam hit to PF02313, Fumarate reductase, D subunit, score 1.6e-84 637910015877 3 transmembrane helices predicted for ROD32151 by TMHMM2.0 at aa 24-46, 66-88 and 109-128 637910015878 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 637910015879 D-subunit interface [polypeptide binding]; other site 637910015880 Iron-sulfur protein interface; other site 637910015881 proximal quinone binding site [chemical binding]; other site 637910015882 distal quinone binding site [chemical binding]; other site 637910015883 HMMPfam hit to PF02300, Fumarate reductase, subunit C, score 7.4e-97 637910015884 3 transmembrane helices predicted for ROD32161 by TMHMM2.0 at aa 28-50, 60-82 and 108-130 637910015885 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 637910015886 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 637910015887 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.00083 637910015888 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910015889 HMMPfam hit to PF00111, Ferredoxin, score 0.0034 637910015890 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 637910015891 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 637910015892 L-aspartate oxidase; Provisional; Region: PRK06175 637910015893 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 637910015894 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydrogenase flavoprotein, C-terminal, score 4.8e-69 637910015895 HMMPfam hit to PF00890, Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal, score 4.3e-157 637910015896 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 637910015897 poxB regulator PoxA; Provisional; Region: PRK09350 637910015898 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 637910015899 motif 1; other site 637910015900 dimer interface [polypeptide binding]; other site 637910015901 active site 637910015902 motif 2; other site 637910015903 motif 3; other site 637910015904 HMMPfam hit to PF00152, Aminoacyl-tRNA synthetase, class II (D, K and N), score 3e-74 637910015905 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 637910015906 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910015907 inner membrane transporter YjeM; Provisional; Region: PRK15238 637910015908 12 transmembrane helices predicted for ROD32201 by TMHMM2.0 at aa 12-34, 39-58, 79-101, 132-154, 161-183, 208-230, 243-265, 310-332, 364-383, 393-415, 435-457 and 467-484 637910015909 HMMPfam hit to PF00324, Amino acid permease-associated region, score 0.00026 637910015910 putative mechanosensitive channel protein; Provisional; Region: PRK10929 637910015911 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 637910015912 Mechanosensitive ion channel; Region: MS_channel; pfam00924 637910015913 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 2.2e-79 637910015914 PS01246 Uncharacterized protein family UPF0003 signature. 637910015915 11 transmembrane helices predicted for ROD32211 by TMHMM2.0 at aa 467-484, 508-530, 545-567, 588-609, 619-640, 661-683, 688-710, 776-798, 818-840, 871-890 and 900-922 637910015916 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 637910015917 HMMPfam hit to PF02666, Phosphatidylserine decarboxylase-related, score 7.4e-113 637910015918 GTPase RsgA; Reviewed; Region: PRK12288 637910015919 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 637910015920 RNA binding site [nucleotide binding]; other site 637910015921 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 637910015922 GTPase/Zn-binding domain interface [polypeptide binding]; other site 637910015923 GTP/Mg2+ binding site [chemical binding]; other site 637910015924 G4 box; other site 637910015925 G5 box; other site 637910015926 G1 box; other site 637910015927 Switch I region; other site 637910015928 G2 box; other site 637910015929 G3 box; other site 637910015930 Switch II region; other site 637910015931 HMMPfam hit to PF03193, GTPase EngC, score 1.2e-146 637910015932 PS00017 ATP/GTP-binding site motif A (P-loop). 637910015933 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 637910015934 catalytic site [active] 637910015935 putative active site [active] 637910015936 putative substrate binding site [chemical binding]; other site 637910015937 dimer interface [polypeptide binding]; other site 637910015938 HMMPfam hit to PF00929, Exonuclease, RNase T and DNA polymerase III, score 7.3e-40 637910015939 PS00017 ATP/GTP-binding site motif A (P-loop). 637910015940 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 637910015941 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 637910015942 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910015943 epoxyqueuosine reductase; Region: TIGR00276 637910015944 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 637910015945 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0041 637910015946 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910015947 HMMPfam hit to PF08331, Region of unknown function DUF1730, score 1.9e-37 637910015948 putative carbohydrate kinase; Provisional; Region: PRK10565 637910015949 Uncharacterized conserved protein [Function unknown]; Region: COG0062 637910015950 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 637910015951 putative substrate binding site [chemical binding]; other site 637910015952 putative ATP binding site [chemical binding]; other site 637910015953 HMMPfam hit to PF03853, YjeF-related protein, N-terminal, score 2.6e-69 637910015954 HMMPfam hit to PF01256, Carbohydrate kinase, score 2.6e-113 637910015955 PS01050 Uncharacterized protein family UPF0031 signature 2. 637910015956 ADP-binding protein; Provisional; Region: PRK10646 637910015957 HMMPfam hit to PF02367, Protein of unknown function UPF0079, ATPase bacteria, score 6.7e-67 637910015958 PS00017 ATP/GTP-binding site motif A (P-loop). 637910015959 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 637910015960 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 637910015961 active site 637910015962 metal binding site [ion binding]; metal-binding site 637910015963 HMMPfam hit to PF01520, Cell wall hydrolase/autolysin, catalytic, score 4.5e-101 637910015964 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 637910015965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910015966 ATP binding site [chemical binding]; other site 637910015967 Mg2+ binding site [ion binding]; other site 637910015968 G-X-G motif; other site 637910015969 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 637910015970 ATP binding site [chemical binding]; other site 637910015971 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 637910015972 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 4e-10 637910015973 PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature. 637910015974 HMMPfam hit to PF01119, DNA mismatch repair protein, C-terminal, score 1.9e-46 637910015975 HMMPfam hit to PF08676, MutL, C-terminal, dimerisation, score 1.1e-22 637910015976 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 637910015977 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 637910015978 PS00017 ATP/GTP-binding site motif A (P-loop). 637910015979 HMMPfam hit to PF01715, tRNA isopentenyltransferase, score 3.4e-162 637910015980 bacterial Hfq-like; Region: Hfq; cd01716 637910015981 hexamer interface [polypeptide binding]; other site 637910015982 Sm1 motif; other site 637910015983 RNA binding site [nucleotide binding]; other site 637910015984 Sm2 motif; other site 637910015985 HMMPfam hit to PF01423, Like-Sm ribonucleoprotein, core, score 3.9e-12 637910015986 GTPase HflX; Provisional; Region: PRK11058 637910015987 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 637910015988 HflX GTPase family; Region: HflX; cd01878 637910015989 G1 box; other site 637910015990 GTP/Mg2+ binding site [chemical binding]; other site 637910015991 Switch I region; other site 637910015992 G2 box; other site 637910015993 G3 box; other site 637910015994 Switch II region; other site 637910015995 G4 box; other site 637910015996 G5 box; other site 637910015997 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 8.9e-39 637910015998 PS00017 ATP/GTP-binding site motif A (P-loop). 637910015999 FtsH protease regulator HflK; Provisional; Region: PRK10930 637910016000 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 637910016001 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 637910016002 HMMPfam hit to PF01145, Band 7 protein, score 6.2e-53 637910016003 FtsH protease regulator HflC; Provisional; Region: PRK11029 637910016004 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 637910016005 1 transmembrane helix predicted for ROD32351 by TMHMM2.0 at aa 5-23 637910016006 HMMPfam hit to PF01145, Band 7 protein, score 1.6e-61 637910016007 PS00055 Ribosomal protein S12 signature. 637910016008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 637910016009 2 transmembrane helices predicted for ROD32361 by TMHMM2.0 at aa 5-27 and 42-60 637910016010 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 637910016011 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 637910016012 GDP-binding site [chemical binding]; other site 637910016013 ACT binding site; other site 637910016014 IMP binding site; other site 637910016015 HMMPfam hit to PF00709, Adenylosuccinate synthetase, score 0 637910016016 PS01266 Adenylosuccinate synthetase GTP-binding site. 637910016017 PS00513 Adenylosuccinate synthetase active site. 637910016018 Predicted transcriptional regulator [Transcription]; Region: COG1959 637910016019 transcriptional repressor NsrR; Provisional; Region: PRK11014 637910016020 HMMPfam hit to PF02082, Transcriptional regulator, Rrf2, score 7.4e-46 637910016021 Predicted helix-turn-helix motif with score 1160.000, SD 3.14 at aa 26-47, sequence TSISEVTEVYGVSRNHMVKIIN 637910016022 exoribonuclease R; Provisional; Region: PRK11642 637910016023 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 637910016024 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 637910016025 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 637910016026 RNB domain; Region: RNB; pfam00773 637910016027 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 637910016028 RNA binding site [nucleotide binding]; other site 637910016029 HMMPfam hit to PF08461, Ribonuclease R winged-helix domain, score 3e-21 637910016030 HMMPfam hit to PF08206, Ribonuclease B, OB region N-terminal, score 9.4e-29 637910016031 HMMPfam hit to PF08206, Ribonuclease B, OB region N-terminal, score 0.00024 637910016032 HMMPfam hit to PF00773, Ribonuclease II and R, score 1.9e-156 637910016033 PS01175 Ribonuclease II family signature. 637910016034 HMMPfam hit to PF00575, S1, RNA binding, score 1.3e-22 637910016035 PS00017 ATP/GTP-binding site motif A (P-loop). 637910016036 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 637910016037 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 637910016038 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 637910016039 HMMPfam hit to PF08032, RNA 2-O ribose methyltransferase, substrate-binding, score 5.7e-22 637910016040 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase, SpoU, score 9.9e-64 637910016041 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 637910016042 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 637910016043 FAD binding site [chemical binding]; other site 637910016044 substrate binding site [chemical binding]; other site 637910016045 catalytic residues [active] 637910016046 HMMPfam hit to PF02771, Acyl-CoA dehydrogenase, N-terminal, score 3.9e-42 637910016047 HMMPfam hit to PF02770, Acyl-CoA dehydrogenase/oxidase, central region, score 9.7e-14 637910016048 PS00072 Acyl-CoA dehydrogenases signature 1. 637910016049 HMMPfam hit to PF00441, Acyl-CoA oxidase/dehydrogenase, type 1, score 2.6e-34 637910016050 PS00073 Acyl-CoA dehydrogenases signature 2. 637910016051 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 637910016052 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 5.8e-43 637910016053 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 637910016054 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 1e-05 637910016055 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016056 esterase; Provisional; Region: PRK10566 637910016057 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 637910016058 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 637910016059 HMMPfam hit to PF02230, Phospholipase/Carboxylesterase, score 0.0001 637910016060 1 transmembrane helix predicted for ROD32441 by TMHMM2.0 at aa 29-51 637910016061 transcriptional repressor UlaR; Provisional; Region: PRK13509 637910016062 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 637910016063 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637910016064 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 1.3e-67 637910016065 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 2.3e-26 637910016066 Predicted helix-turn-helix motif with score 1188.000, SD 3.23 at aa 20-41, sequence VTVENVVERLGISPATARRDIN 637910016067 PS00894 Bacterial regulatory proteins, deoR family signature. 637910016068 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 637910016069 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 637910016070 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 637910016072 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 637910016073 HMMPfam hit to PF04215, sugar-specific permease, SgaT/UlaA, score 1e-276 637910016074 10 transmembrane helices predicted for ROD32471 by TMHMM2.0 at aa 15-34, 41-63, 100-122, 143-172, 233-252, 264-286, 306-328, 340-362, 377-399 and 424-446 637910016075 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 637910016076 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016077 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 637910016078 active site 637910016079 P-loop; other site 637910016080 phosphorylation site [posttranslational modification] 637910016081 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 4.5e-33 637910016082 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637910016083 active site 637910016084 phosphorylation site [posttranslational modification] 637910016085 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 7.3e-72 637910016086 PS00372 PTS EIIA domains phosphorylation site signature 2. 637910016087 PS00387 Inorganic pyrophosphatase signature. 637910016088 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 637910016089 active site 637910016090 dimer interface [polypeptide binding]; other site 637910016091 magnesium binding site [ion binding]; other site 637910016092 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase, core, score 5.8e-61 637910016093 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 637910016094 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 637910016095 AP (apurinic/apyrimidinic) site pocket; other site 637910016096 DNA interaction; other site 637910016097 Metal-binding active site; metal-binding site 637910016098 HMMPfam hit to PF01261, Xylose isomerase-type TIM barrel, score 8.2e-44 637910016099 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 637910016100 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 637910016101 intersubunit interface [polypeptide binding]; other site 637910016102 active site 637910016103 Zn2+ binding site [ion binding]; other site 637910016104 HMMPfam hit to PF00596, Class II aldolase/adducin, N-terminal, score 3.8e-95 637910016105 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 637910016106 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 1.2e-29 637910016107 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 637910016108 HMMPfam hit to PF01250, Ribosomal protein S6, score 2.2e-50 637910016109 PS01048 Ribosomal protein S6 signature. 637910016110 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 637910016111 dimer interface [polypeptide binding]; other site 637910016112 ssDNA binding site [nucleotide binding]; other site 637910016113 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637910016114 HMMPfam hit to PF00436, Primosome PriB/single-strand DNA-binding, score 1.2e-16 637910016115 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 637910016116 HMMPfam hit to PF01084, Ribosomal protein S18, score 1.3e-32 637910016117 PS00057 Ribosomal protein S18 signature. 637910016118 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 637910016119 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 637910016120 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 637910016121 HMMPfam hit to PF01281, Ribosomal protein L9, score 4.1e-27 637910016122 PS00651 Ribosomal protein L9 signature. 637910016123 HMMPfam hit to PF03948, Ribosomal protein L9, score 1.6e-45 637910016124 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 637910016125 EamA-like transporter family; Region: EamA; pfam00892 637910016126 EamA-like transporter family; Region: EamA; pfam00892 637910016127 10 transmembrane helices predicted for ROD32591 by TMHMM2.0 at aa 15-34, 54-71, 86-108, 115-134, 144-163, 165-187, 202-224, 231-253, 258-280 and 287-304 637910016128 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 4.9e-12 637910016129 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 3.2e-11 637910016130 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016131 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 637910016132 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 637910016133 HMMPfam hit to PF04225, Opacity-associated protein A, score 1.6e-54 637910016134 HMMPfam hit to PF08525, Opacity-associated protein A, N-terminal, score 3.3e-08 637910016135 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 637910016136 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 637910016137 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 637910016138 HMMPfam hit to PF01346, Peptidyl-prolyl cis-trans isomerase, FKBP-type, N-terminal, score 1.6e-05 637910016139 HMMPfam hit to PF00254, Peptidyl-prolyl cis-trans isomerase, FKBP-type, score 3.3e-47 637910016140 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 637910016141 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 637910016142 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 637910016143 HMMPfam hit to PF00324, Amino acid permease-associated region, score 1.9e-168 637910016144 12 transmembrane helices predicted for ROD32621 by TMHMM2.0 at aa 27-44, 49-71, 104-126, 136-158, 165-187, 210-232, 252-274, 289-311, 342-364, 374-396, 417-435 and 439-461 637910016145 PS00218 Amino acid permeases signature. 637910016146 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 637910016147 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 637910016148 Hemerythrin-like domain; Region: Hr-like; cd12108 637910016149 Fe binding site [ion binding]; other site 637910016150 HMMPfam hit to PF01814, Hemerythrin HHE cation binding region, score 0.0012 637910016151 HMMPfam hit to PF01814, Hemerythrin HHE cation binding region, score 2.1e-07 637910016152 HMMPfam hit to PF04405, Protein of unknown function DUF542, ScdA N-terminal, score 4.3e-42 637910016153 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 637910016154 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 637910016155 dimer interface [polypeptide binding]; other site 637910016156 ligand binding site [chemical binding]; other site 637910016157 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637910016158 dimerization interface [polypeptide binding]; other site 637910016159 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637910016160 dimer interface [polypeptide binding]; other site 637910016161 putative CheW interface [polypeptide binding]; other site 637910016162 2 transmembrane helices predicted for ROD32641 by TMHMM2.0 at aa 10-32 and 192-214 637910016163 HMMPfam hit to PF02203, Ligand binding Tar, score 1.4e-09 637910016164 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 3.9e-15 637910016165 PS00538 Bacterial chemotaxis sensory transducers signature. 637910016166 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 9.5e-109 637910016167 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 637910016168 EamA-like transporter family; Region: EamA; pfam00892 637910016169 10 transmembrane helices predicted for ROD32651 by TMHMM2.0 at aa 5-25, 35-52, 64-86, 91-113, 120-142, 152-174, 195-217, 232-254, 259-281 and 286-305 637910016170 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 1.5e-07 637910016171 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 637910016172 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 637910016173 NADP binding site [chemical binding]; other site 637910016174 HMMPfam hit to PF07993, Male sterility C-terminal, score 5.2e-07 637910016175 Predicted transcriptional regulators [Transcription]; Region: COG1733 637910016176 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 637910016177 HMMPfam hit to PF01638, Helix-turn-helix, HxlR type, score 5e-53 637910016178 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 637910016179 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 637910016180 active site 637910016181 metal binding site [ion binding]; metal-binding site 637910016182 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 637910016183 HMMPfam hit to PF02872, 5'-Nucleotidase, C-terminal, score 7e-63 637910016184 HMMPfam hit to PF00149, Metallophosphoesterase, score 1.6e-19 637910016185 PS00786 5'-nucleotidase signature 2. 637910016186 PS00785 5'-nucleotidase signature 1. 637910016187 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 637910016188 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 637910016189 active site 637910016190 HMMPfam hit to PF00459, Inositol monophosphatase, score 1.4e-76 637910016191 PS00629 Inositol monophosphatase family signature 1. 637910016192 PS00630 Inositol monophosphatase family signature 2. 637910016193 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 637910016194 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 637910016195 HMMPfam hit to PF06526, Protein of unknown function DUF1107, score 1.7e-46 637910016196 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 637910016197 Domain of unknown function DUF21; Region: DUF21; pfam01595 637910016198 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 637910016199 Transporter associated domain; Region: CorC_HlyC; smart01091 637910016200 HMMPfam hit to PF03471, Transporter-associated region, score 4.1e-24 637910016201 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 7.9e-16 637910016202 HMMPfam hit to PF01595, Protein of unknown function DUF21, score 1.4e-71 637910016203 4 transmembrane helices predicted for ROD32721 by TMHMM2.0 at aa 5-27, 58-80, 100-117 and 143-165 637910016204 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 637910016205 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 637910016206 12 transmembrane helices predicted for ROD32731 by TMHMM2.0 at aa 13-35, 50-72, 89-106, 110-132, 149-171, 181-203, 250-272, 282-304, 316-338, 342-364, 385-407 and 427-449 637910016207 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 6.4e-09 637910016208 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637910016209 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637910016210 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 637910016211 PS00017 ATP/GTP-binding site motif A (P-loop). 637910016212 HMMPfam hit to PF02894, Oxidoreductase, C-terminal, score 5.5e-05 637910016213 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 7.2e-31 637910016214 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637910016215 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637910016216 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 637910016217 HMMPfam hit to PF02894, Oxidoreductase, C-terminal, score 0.075 637910016218 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 7.2e-08 637910016219 pseudogene, truncated by premature stop codon 637910016220 HMMPfam hit to PF02894, Oxidoreductase, C-terminal, score 7.7e-16 637910016221 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 2.1e-32 637910016222 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637910016223 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637910016224 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 637910016225 HMMPfam hit to PF02894, Oxidoreductase, C-terminal, score 1.2e-09 637910016226 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 5e-28 637910016227 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637910016228 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910016229 DNA binding site [nucleotide binding] 637910016230 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 637910016231 ligand binding site [chemical binding]; other site 637910016232 dimerization interface [polypeptide binding]; other site 637910016233 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 3.2e-07 637910016234 Predicted helix-turn-helix motif with score 1514.000, SD 4.34 at aa 5-26, sequence LKMDEIAALTGFSVSTVSRVLS 637910016235 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 0.00041 637910016236 methionine sulfoxide reductase A; Provisional; Region: PRK00058 637910016237 HMMPfam hit to PF01625, Methionine sulphoxide reductase A, score 1.1e-109 637910016238 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 637910016239 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 637910016240 Surface antigen; Region: Bac_surface_Ag; pfam01103 637910016241 HMMPfam hit to PF07244, Surface antigen variable number, score 6.6e-11 637910016242 HMMPfam hit to PF01103, Bacterial surface antigen (D15), score 2.3e-80 637910016243 PS00213 Lipocalin signature. 637910016244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 637910016245 Family of unknown function (DUF490); Region: DUF490; pfam04357 637910016246 1 transmembrane helix predicted for ROD32821 by TMHMM2.0 at aa 7-29 637910016247 PS00213 Lipocalin signature. 637910016248 HMMPfam hit to PF04357, Protein of unknown function DUF490, score 9.2e-169 637910016249 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 637910016250 putative active site pocket [active] 637910016251 dimerization interface [polypeptide binding]; other site 637910016252 putative catalytic residue [active] 637910016253 HMMPfam hit to PF03674, Protein of unknown function UPF0131, score 1.9e-48 637910016254 antitoxin ChpS; Provisional; Region: PRK11347 637910016255 HMMPfam hit to PF04014, SpoVT/AbrB-like, predicted transcription regulator, score 2.8e-08 637910016256 toxin ChpB; Provisional; Region: PRK09812 637910016257 HMMPfam hit to PF02452, PemK-like protein, score 3.2e-37 637910016258 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 637910016259 dimer interface [polypeptide binding]; other site 637910016260 substrate binding site [chemical binding]; other site 637910016261 metal binding sites [ion binding]; metal-binding site 637910016262 HMMPfam hit to PF00719, Inorganic pyrophosphatase, score 3.6e-62 637910016263 PS00387 Inorganic pyrophosphatase signature. 637910016264 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 637910016265 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 637910016266 putative ligand binding site [chemical binding]; other site 637910016267 1 transmembrane helix predicted for ROD32871 by TMHMM2.0 at aa 5-27 637910016268 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 9.7e-07 637910016269 PS00063 Aldo/keto reductase family active site signature. 637910016270 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 637910016271 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637910016272 Walker A/P-loop; other site 637910016273 ATP binding site [chemical binding]; other site 637910016274 Q-loop/lid; other site 637910016275 ABC transporter signature motif; other site 637910016276 Walker B; other site 637910016277 D-loop; other site 637910016278 H-loop/switch region; other site 637910016279 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637910016280 HMMPfam hit to PF00005, ABC transporter related, score 1.7e-64 637910016281 PS00017 ATP/GTP-binding site motif A (P-loop). 637910016282 HMMPfam hit to PF00005, ABC transporter related, score 4.3e-20 637910016283 PS00211 ABC transporters family signature. 637910016284 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637910016285 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637910016286 TM-ABC transporter signature motif; other site 637910016287 9 transmembrane helices predicted for ROD32901 by TMHMM2.0 at aa 24-46, 67-89, 109-131, 136-158, 173-195, 223-245, 255-274, 281-303 and 313-330 637910016288 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 2.2e-77 637910016289 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637910016290 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637910016291 TM-ABC transporter signature motif; other site 637910016292 9 transmembrane helices predicted for ROD32911 by TMHMM2.0 at aa 7-29, 44-61, 63-85, 90-109, 116-135, 158-180, 214-236, 251-273 and 286-308 637910016293 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 4.5e-54 637910016294 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016295 HAMP domain; Region: HAMP; pfam00672 637910016296 dimerization interface [polypeptide binding]; other site 637910016297 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637910016298 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637910016299 dimer interface [polypeptide binding]; other site 637910016300 putative CheW interface [polypeptide binding]; other site 637910016301 2 transmembrane helices predicted for ROD32921 by TMHMM2.0 at aa 10-32 and 39-61 637910016302 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 1.1e-11 637910016303 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 2.9e-94 637910016304 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 637910016305 AMP binding site [chemical binding]; other site 637910016306 metal binding site [ion binding]; metal-binding site 637910016307 active site 637910016308 HMMPfam hit to PF00316, Inositol phosphatase/fructose-1,6-bisphosphatase, score 5.9e-222 637910016309 PS00124 Fructose-1-6-bisphosphatase active site. 637910016310 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 637910016311 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 637910016312 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 637910016313 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 637910016314 HMMPfam hit to PF01225, Mur ligase, N-terminal, score 1.7e-30 637910016315 HMMPfam hit to PF08245, Mur ligase, central, score 2e-11 637910016316 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 1.1e-07 637910016317 hypothetical protein; Provisional; Region: PRK05255 637910016318 HMMPfam hit to PF04751, Protein of unknown function DUF615, score 7.3e-116 637910016319 peptidase PmbA; Provisional; Region: PRK11040 637910016320 HMMPfam hit to PF01523, Peptidase U62, modulator of DNA gyrase, score 1e-102 637910016321 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 637910016322 HMMPfam hit to PF05973, Protein of unknown function DUF891, score 1.7e-20 637910016323 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 637910016324 HMMPfam hit to PF00874, PRD, score 5.4e-10 637910016325 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 637910016326 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 637910016327 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 637910016328 6 transmembrane helices predicted for ROD33011 by TMHMM2.0 at aa 2-24, 55-77, 111-133, 143-165, 177-199 and 214-232 637910016329 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 637910016330 6 transmembrane helices predicted for ROD33021 by TMHMM2.0 at aa 15-37, 57-74, 84-106, 111-133, 165-187 and 194-213 637910016331 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637910016332 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637910016333 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637910016334 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 1.2e-17 637910016335 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.2e-27 637910016336 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 637910016337 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 637910016338 active site 637910016339 HMMPfam hit to PF07969, Amidohydrolase 3, score 6.4e-05 637910016340 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 637910016341 HMMPfam hit to PF01212, Aromatic amino acid beta-eliminating lyase/threonine aldolase, score 0.00039 637910016342 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 637910016343 HMMPfam hit to PF07071, Protein of unknown function DUF1341, score 8.7e-163 637910016344 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 637910016345 HTH domain; Region: HTH_11; pfam08279 637910016346 Mga helix-turn-helix domain; Region: Mga; pfam05043 637910016347 PRD domain; Region: PRD; pfam00874 637910016348 PRD domain; Region: PRD; pfam00874 637910016349 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 637910016350 active site 637910016351 P-loop; other site 637910016352 phosphorylation site [posttranslational modification] 637910016353 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637910016354 active site 637910016355 phosphorylation site [posttranslational modification] 637910016356 HMMPfam hit to PF08279, Helix-turn-helix, type 11, score 1.4e-15 637910016357 PS00894 Bacterial regulatory proteins, deoR family signature. 637910016358 Predicted helix-turn-helix motif with score 1542.000, SD 4.44 at aa 20-41, sequence LPQDELAQRLSVSTRTVRADIS 637910016359 Predicted helix-turn-helix motif with score 1542.000, SD 4.44 at aa 107-41, sequence SALNALLTGHGAQFILSRGNGYQLRIDDPASFKSLQTQQPSMLRIPRSSQERVHYLM VRFLTSAFSI 637910016360 HMMPfam hit to PF05043, M trans-acting positive regulator, score 2.1e-08 637910016361 Predicted helix-turn-helix motif with score 1221.000, SD 3.35 at aa 107-128, sequence IKLEDLADEWFVSRATLQNDMA 637910016362 HMMPfam hit to PF00874, PRD, score 1.6e-08 637910016363 HMMPfam hit to PF00874, PRD, score 2.8e-16 637910016364 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 0.00011 637910016365 PS00372 PTS EIIA domains phosphorylation site signature 2. 637910016366 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 637910016367 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910016368 FeS/SAM binding site; other site 637910016369 PS01087 Radical activating enzymes signature. 637910016370 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 637910016371 ATP cone domain; Region: ATP-cone; pfam03477 637910016372 Class III ribonucleotide reductase; Region: RNR_III; cd01675 637910016373 effector binding site; other site 637910016374 active site 637910016375 Zn binding site [ion binding]; other site 637910016376 glycine loop; other site 637910016377 HMMPfam hit to PF01228, Formate C-acetyltransferase glycine radical, score 1.5e-58 637910016378 PS00850 Glycine radical signature. 637910016379 HMMPfam hit to PF03477, ATP-cone, score 3.8e-31 637910016380 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 637910016381 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 637910016382 Ca binding site [ion binding]; other site 637910016383 active site 637910016384 catalytic site [active] 637910016385 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 637910016386 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 1.1e-147 637910016387 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 637910016388 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637910016389 active site turn [active] 637910016390 phosphorylation site [posttranslational modification] 637910016391 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 637910016392 10 transmembrane helices predicted for ROD33111 by TMHMM2.0 at aa 107-129, 157-179, 186-208, 223-245, 257-279, 299-321, 342-361, 371-393, 406-428 and 438-460 637910016393 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 9e-28 637910016394 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 1.1e-09 637910016395 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 637910016396 trehalose repressor; Provisional; Region: treR; PRK09492 637910016397 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910016398 DNA binding site [nucleotide binding] 637910016399 domain linker motif; other site 637910016400 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 637910016401 dimerization interface [polypeptide binding]; other site 637910016402 ligand binding site [chemical binding]; other site 637910016403 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 3.2e-05 637910016404 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 8.5e-13 637910016405 Predicted helix-turn-helix motif with score 2311.000, SD 7.06 at aa 5-26, sequence LTIKDIARLSGVGKSTVSRVLN 637910016406 PS00356 Bacterial regulatory proteins, lacI family signature. 637910016407 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 637910016408 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 637910016409 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637910016410 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 637910016411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910016412 motif II; other site 637910016413 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 637910016414 HMMPfam hit to PF00690, ATPase, P-type cation-transporter N-terminal, score 2.5e-15 637910016415 7 transmembrane helices predicted for ROD33131 by TMHMM2.0 at aa 130-149, 303-322, 722-744, 780-802, 812-834, 847-866 and 881-903 637910016416 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 1.8e-92 637910016417 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.2e-17 637910016418 PS00154 E1-E2 ATPases phosphorylation site. 637910016419 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 637910016420 homotrimer interaction site [polypeptide binding]; other site 637910016421 putative active site [active] 637910016422 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 4.4e-62 637910016423 PS01094 Uncharacterized protein family UPF0076 signature. 637910016424 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 637910016425 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 637910016426 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 637910016427 HMMPfam hit to PF02748, Aspartate transcarbamylase regulatory subunit, score 1e-28 637910016428 PS00430 TonB-dependent receptor proteins signature 1. 637910016429 HMMPfam hit to PF01948, Aspartate transcarbamylase regulatory subunit, score 9.3e-65 637910016430 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 637910016431 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 637910016432 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 637910016433 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region, score 2e-66 637910016434 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding, score 3.6e-78 637910016435 PS00097 Aspartate and ornithine carbamoyltransferases signature. 637910016436 pyrBI operon leader peptide; Provisional; Region: PRK10224 637910016437 HMMPfam hit to PF08052, PyrBI operon leader peptide, score 7e-13 637910016438 Arginine repressor [Transcription]; Region: ArgR; COG1438 637910016439 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 637910016440 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 637910016441 HMMPfam hit to PF02863, Arginine repressor, score 3.2e-23 637910016442 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016443 HMMPfam hit to PF01316, Arginine repressor, score 1.4e-09 637910016444 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 637910016445 HMMPfam hit to PF04074, Conserved hypothetical protein CHP00022, score 1.4e-73 637910016446 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 637910016447 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 637910016448 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 637910016449 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region, score 2.6e-98 637910016450 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding, score 3.2e-88 637910016451 PS00097 Aspartate and ornithine carbamoyltransferases signature. 637910016452 RNase E inhibitor protein; Provisional; Region: PRK11191 637910016453 HMMPfam hit to PF06877, Protein of unknown function DUF1260, score 1.2e-45 637910016454 Lipopolysaccharide-assembly; Region: LptE; cl01125 637910016455 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 637910016456 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.8e-21 637910016457 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 637910016458 HMMPfam hit to PF05987, Protein of unknown function DUF898, transmembrane bacterial, score 9.6e-121 637910016459 8 transmembrane helices predicted for ROD33231 by TMHMM2.0 at aa 23-45, 74-93, 97-119, 140-162, 177-199, 230-252, 280-302 and 328-350 637910016460 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 637910016461 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 637910016462 HIGH motif; other site 637910016463 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 637910016464 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 637910016465 active site 637910016466 KMSKS motif; other site 637910016467 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 637910016468 tRNA binding surface [nucleotide binding]; other site 637910016469 anticodon binding site; other site 637910016470 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 637910016471 HMMPfam hit to PF08264, Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding, score 3.8e-67 637910016472 HMMPfam hit to PF00133, Aminoacyl-tRNA synthetase, class Ia, score 0 637910016473 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 637910016474 DNA polymerase III subunit chi; Validated; Region: PRK05728 637910016475 HMMPfam hit to PF04364, DNA polymerase III chi subunit, HolC, score 1.4e-78 637910016476 multifunctional aminopeptidase A; Provisional; Region: PRK00913 637910016477 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 637910016478 interface (dimer of trimers) [polypeptide binding]; other site 637910016479 Substrate-binding/catalytic site; other site 637910016480 Zn-binding sites [ion binding]; other site 637910016481 HMMPfam hit to PF00883, Peptidase M17, leucyl aminopeptidase, C-terminal, score 2e-205 637910016482 PS00631 Cytosol aminopeptidase signature. 637910016483 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016484 HMMPfam hit to PF02789, Peptidase M17, leucyl aminopeptidase, N-terminal, score 1.1e-43 637910016485 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 637910016486 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 637910016487 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ, score 1.7e-76 637910016488 6 transmembrane helices predicted for ROD33271 by TMHMM2.0 at aa 17-39, 54-76, 97-119, 267-289, 296-313 and 328-348 637910016489 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 637910016490 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 637910016491 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ, score 2.1e-93 637910016492 6 transmembrane helices predicted for ROD33281 by TMHMM2.0 at aa 10-32, 64-83, 103-125, 279-301, 305-322 and 329-351 637910016493 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 637910016494 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 637910016495 HMMPfam hit to PF05872, Protein of unknown function DUF853, NPT hydrolase , score 0 637910016496 PS00017 ATP/GTP-binding site motif A (P-loop). 637910016497 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 637910016498 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 637910016499 putative NAD(P) binding site [chemical binding]; other site 637910016500 putative substrate binding site [chemical binding]; other site 637910016501 catalytic Zn binding site [ion binding]; other site 637910016502 structural Zn binding site [ion binding]; other site 637910016503 dimer interface [polypeptide binding]; other site 637910016504 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 5.1e-33 637910016505 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 637910016506 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 3.7e-40 637910016507 PS00059 Zinc-containing alcohol dehydrogenases signature. 637910016508 PS00190 Cytochrome c family heme-binding site signature. 637910016509 CR_GI10; degenerate ICE element ICECr1 637910016510 pseudogene, truncated by frameshift mutation 637910016511 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 637910016512 Putative helicase; Region: TraI_2; pfam07514 637910016513 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 637910016514 HMMPfam hit to PF07515, Protein of unknown function DUF1528, C-terminal, score 2.1e-34 637910016515 HMMPfam hit to PF07514, Protein of unknown function, helicase/relaxase, score 2.4e-111 637910016516 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 637910016517 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 637910016518 HMMPfam hit to PF08401, Region of unknown function DUF1738, score 1.3e-54 637910016519 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 637910016520 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 637910016521 HMMPfam hit to PF01420, Restriction endonuclease, type I, S subunit, EcoBI, score 3.5e-05 637910016522 1 transmembrane helix predicted for ROD33371 by TMHMM2.0 at aa 78-100 637910016523 HMMPfam hit to PF01420, Restriction endonuclease, type I, S subunit, EcoBI, score 3.3e-14 637910016524 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910016526 Walker A/P-loop; other site 637910016527 ATP binding site [chemical binding]; other site 637910016528 AAA domain; Region: AAA_21; pfam13304 637910016529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910016530 ABC transporter signature motif; other site 637910016531 Walker B; other site 637910016532 D-loop; other site 637910016533 H-loop/switch region; other site 637910016534 HMMPfam hit to PF02463, SMC protein, N-terminal, score 6.2e-06 637910016535 PS00017 ATP/GTP-binding site motif A (P-loop). 637910016536 pseudogene, disrupted by IS102 insertion 637910016537 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 637910016538 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910016539 HMMPfam hit to PF01609, Transposase, IS4-like, score 9.3e-30 637910016540 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 637910016541 HsdM N-terminal domain; Region: HsdM_N; pfam12161 637910016542 Methyltransferase domain; Region: Methyltransf_26; pfam13659 637910016543 HMMPfam hit to PF02384, N-6 DNA methylase, score 5.8e-62 637910016544 PS00092 N-6 Adenine-specific DNA methylases signature. 637910016545 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 637910016546 5 transmembrane helices predicted for ROD33431 by TMHMM2.0 at aa 21-43, 63-85, 358-380, 384-402 and 438-460 637910016547 3 transmembrane helices predicted for ROD33441 by TMHMM2.0 at aa 4-21, 34-53 and 63-80 637910016548 pseudogene, truncated by frameshift mutation and premature stop codon 637910016549 HMMPfam hit to PF07513, Protein of unknown function DUF1527, score 5.1e-21 637910016550 pseudogene, N-terminus missing, fragment 637910016551 pseudogene, C-terminus missing, fragment 637910016552 HMMPfam hit to PF00884, Sulphatase, score 1.1e-20 637910016553 pseudogene, C-terminus missing, N-terminal part truncated by frameshift mutation 637910016554 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 637910016555 pseudogene, N-terminus missing due to start codon mutation, truncated by frameshift mutation 637910016556 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 637910016557 2 transmembrane helices predicted for ROD33521 by TMHMM2.0 at aa 26-48 and 52-74 637910016558 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 637910016559 2 transmembrane helices predicted for ROD33531 by TMHMM2.0 at aa 46-68 and 83-102 637910016560 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 637910016561 2 transmembrane helices predicted for ROD33541 by TMHMM2.0 at aa 20-39 and 54-76 637910016562 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 637910016563 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 637910016564 1 transmembrane helix predicted for ROD33561 by TMHMM2.0 at aa 10-27 637910016565 4 transmembrane helices predicted for ROD33571 by TMHMM2.0 at aa 45-63, 73-92, 154-176 and 189-206 637910016566 6 transmembrane helices predicted for ROD33581 by TMHMM2.0 at aa 5-22, 37-59, 72-94, 104-126, 138-160 and 170-187 637910016567 PS00012 Phosphopantetheine attachment site. 637910016568 pseudogene, truncated by premature stop codon 637910016569 pseudogene, N-terminus missing, C-terminal part truncated by frameshift mutation 637910016570 pseudogene, N-terminus missing, fragment 637910016571 pseudogene, C-terminus missing, fragment 637910016572 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 637910016573 1 transmembrane helix predicted for ROD33641 by TMHMM2.0 at aa 5-24 637910016574 pseudogene, C-terminus missing, fragment 637910016575 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 637910016576 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 637910016577 integrating conjugative element protein, PFL_4669 family; Region: ICE_PFL4669; TIGR03761 637910016578 HMMPfam hit to PF08900, Protein of unknown function DUF1845, score 1.1e-92 637910016579 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637910016580 salt bridge; other site 637910016581 non-specific DNA binding site [nucleotide binding]; other site 637910016582 sequence-specific DNA binding site [nucleotide binding]; other site 637910016583 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 1.2e-11 637910016584 Predicted helix-turn-helix motif with score 2182.000, SD 6.62 at aa 26-47, sequence LTQKDIAERLGVTQQTYARLEA 637910016585 Fic family protein [Function unknown]; Region: COG3177 637910016586 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 637910016587 Fic/DOC family; Region: Fic; pfam02661 637910016588 HMMPfam hit to PF02661, Filamentation induced by cAMP protein Fic, score 5.6e-23 637910016589 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 637910016590 pseudogene, truncated by frameshift mutation 637910016591 replicative DNA helicase; Region: DnaB; TIGR00665 637910016592 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 637910016593 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 637910016594 Walker A motif; other site 637910016595 ATP binding site [chemical binding]; other site 637910016596 Walker B motif; other site 637910016597 DNA binding loops [nucleotide binding] 637910016598 HMMPfam hit to PF03796, DNA helicase, DnaB-like, C-terminal, score 7.8e-88 637910016599 Predicted helix-turn-helix motif with score 1274.000, SD 3.53 at aa 347-368, sequence RSLKALAKELNCPVLALSQLNR 637910016600 PS00017 ATP/GTP-binding site motif A (P-loop). 637910016601 HMMPfam hit to PF00772, DNA helicase, DnaB-like, N-terminal, score 2.8e-48 637910016602 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 637910016603 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 637910016604 P-loop; other site 637910016605 Magnesium ion binding site [ion binding]; other site 637910016606 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 637910016607 Magnesium ion binding site [ion binding]; other site 637910016608 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 637910016609 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637910016610 DNA binding site [nucleotide binding] 637910016611 active site 637910016612 Int/Topo IB signature motif; other site 637910016613 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 8e-15 637910016614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910016615 Transposase; Region: HTH_Tnp_1; pfam01527 637910016616 HMMPfam hit to PF01527, Transposase IS3/IS911, score 5.2e-23 637910016617 Predicted helix-turn-helix motif with score 1681.000, SD 4.91 at aa 23-44, sequence YSVAEVSDRLGVSAHSLYKWLR 637910016618 putative transposase OrfB; Reviewed; Region: PHA02517 637910016619 HTH-like domain; Region: HTH_21; pfam13276 637910016620 Integrase core domain; Region: rve; pfam00665 637910016621 Integrase core domain; Region: rve_3; pfam13683 637910016622 HMMPfam hit to PF00665, Integrase, catalytic core, score 1.3e-45 637910016623 PS00501 Signal peptidases I serine active site. 637910016624 pseudogene, N-terminus deleted by ISEc14 insertion, C-terminus missing, remaining fragment truncated by premature stop codon 637910016625 HMMPfam hit to PF00665, Integrase, catalytic core, score 8.6e-18 637910016626 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 637910016627 HMMPfam hit to PF03992, Antibiotic biosynthesis monooxygenase, score 3.2e-11 637910016628 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910016629 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 637910016630 HNH endonuclease; Region: HNH_2; pfam13391 637910016631 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 637910016632 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 637910016633 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 637910016634 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 637910016635 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 637910016636 HMMPfam hit to PF01315, Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead, score 2.2e-24 637910016637 HMMPfam hit to PF02738, Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding, score 3.3e-150 637910016638 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016639 HMMPfam hit to PF00941, Molybdopterin dehydrogenase, FAD-binding, score 1e-55 637910016640 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 637910016641 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 637910016642 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 637910016643 PS00697 ATP-dependent DNA ligase AMP-binding site. 637910016644 HMMPfam hit to PF00111, Ferredoxin, score 2.5e-06 637910016645 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 637910016646 HMMPfam hit to PF01799, [2Fe-2S]-binding, score 2.4e-36 637910016647 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 637910016648 Ligand binding site; other site 637910016649 metal-binding site 637910016650 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 637910016651 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 637910016652 [4Fe-4S] binding site [ion binding]; other site 637910016653 molybdopterin cofactor binding site; other site 637910016654 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 637910016655 molybdopterin cofactor binding site; other site 637910016656 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 9.9e-33 637910016657 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016658 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 4e-163 637910016659 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 637910016660 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 6.8e-17 637910016661 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 637910016662 xanthine permease; Region: pbuX; TIGR03173 637910016663 13 transmembrane helices predicted for ROD33921 by TMHMM2.0 at aa 28-50, 60-82, 85-107, 111-133, 145-167, 177-199, 206-228, 248-270, 291-313, 328-350, 357-379, 389-408 and 415-437 637910016664 HMMPfam hit to PF00860, Xanthine/uracil/vitamin C permease, score 2.8e-97 637910016665 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 637910016666 4Fe-4S binding domain; Region: Fer4; pfam00037 637910016667 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637910016668 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637910016669 PS00190 Cytochrome c family heme-binding site signature. 637910016670 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 2e-07 637910016671 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910016672 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 4.5e-15 637910016673 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016674 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 0.00079 637910016675 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 637910016676 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 1.5e-06 637910016677 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910016678 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 637910016679 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 637910016680 active site 637910016681 putative substrate binding pocket [chemical binding]; other site 637910016682 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 637910016683 HMMPfam hit to PF01979, Amidohydrolase 1, score 5.1e-56 637910016684 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 637910016685 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 637910016686 phosphate binding site [ion binding]; other site 637910016687 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637910016688 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910016689 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 1.1e-18 637910016690 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 0.0036 637910016691 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 637910016692 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 637910016693 XdhC Rossmann domain; Region: XdhC_C; pfam13478 637910016694 HMMPfam hit to PF02625, XdhC- CoxI, score 5.5e-27 637910016695 carbamate kinase; Reviewed; Region: PRK12686 637910016696 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 637910016697 putative substrate binding site [chemical binding]; other site 637910016698 nucleotide binding site [chemical binding]; other site 637910016699 nucleotide binding site [chemical binding]; other site 637910016700 homodimer interface [polypeptide binding]; other site 637910016701 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 4.7e-93 637910016702 phenylhydantoinase; Validated; Region: PRK08323 637910016703 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 637910016704 tetramer interface [polypeptide binding]; other site 637910016705 active site 637910016706 HMMPfam hit to PF01979, Amidohydrolase 1, score 2.1e-06 637910016707 peptidase; Reviewed; Region: PRK13004 637910016708 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 637910016709 putative metal binding site [ion binding]; other site 637910016710 putative dimer interface [polypeptide binding]; other site 637910016711 HMMPfam hit to PF01546, Peptidase M20, score 1.2e-21 637910016712 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 637910016713 HMMPfam hit to PF07687, Peptidase M20, dimerisation, score 3.2e-19 637910016714 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 637910016715 PS00148 Arginase family signature 2. 637910016716 diaminopropionate ammonia-lyase; Provisional; Region: PRK08206 637910016717 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 637910016718 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637910016719 catalytic residue [active] 637910016720 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 1e-10 637910016721 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016722 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 637910016723 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 637910016724 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 637910016725 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region, score 2.5e-05 637910016726 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding, score 7e-12 637910016727 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 637910016728 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 637910016729 PAS domain; Region: PAS; smart00091 637910016730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910016731 Walker A motif; other site 637910016732 ATP binding site [chemical binding]; other site 637910016733 Walker B motif; other site 637910016734 arginine finger; other site 637910016735 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 637910016736 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 2.6e-145 637910016737 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 637910016738 PS00688 Sigma-54 interaction domain C-terminal part signature. 637910016739 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 4e-15 637910016740 Predicted helix-turn-helix motif with score 1552.000, SD 4.47 at aa 562-583, sequence SNKKQVASELGIGIATLYRKIK 637910016741 Methyltransferase domain; Region: Methyltransf_31; pfam13847 637910016742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910016743 S-adenosylmethionine binding site [chemical binding]; other site 637910016744 HMMPfam hit to PF08241, Methyltransferase type 11, score 9e-05 637910016745 Methyltransferase domain; Region: Methyltransf_23; pfam13489 637910016746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910016747 S-adenosylmethionine binding site [chemical binding]; other site 637910016748 HMMPfam hit to PF08241, Methyltransferase type 11, score 2.5e-19 637910016749 hypothetical protein; Provisional; Region: PRK13687 637910016750 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 637910016751 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 637910016752 putative dimer interface [polypeptide binding]; other site 637910016753 HMMPfam hit to PF00011, Heat shock protein Hsp20, score 4.1e-15 637910016754 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 637910016755 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 637910016756 PS00017 ATP/GTP-binding site motif A (P-loop). 637910016757 HMMPfam hit to PF06812, ImpA, N-terminal, score 3e-11 637910016758 pseudogene, truncated by frameshift mutation 637910016759 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 637910016760 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 637910016761 HMMPfam hit to PF05936, Protein of unknown function DUF876, bacterial, score 1.1e-08 637910016762 1 transmembrane helix predicted for ROD34161 by TMHMM2.0 at aa 5-27 637910016763 Protein of unknown function (DUF770); Region: DUF770; pfam05591 637910016764 HMMPfam hit to PF05591, Uncharacterised conserved protein UCP028301, score 5.8e-79 637910016765 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 637910016766 Protein of unknown function (DUF877); Region: DUF877; pfam05943 637910016767 HMMPfam hit to PF05943, Protein of unknown function DUF877, score 0 637910016768 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 637910016769 HMMPfam hit to PF05638, Virulence factor for secretion apparatus, score 1.7e-60 637910016770 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 637910016771 HMMPfam hit to PF04965, GPW/gp25, score 1.2e-09 637910016772 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 637910016773 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 637910016774 HMMPfam hit to PF05947, Protein of unknown function DUF879, bacterial, score 1.1e-118 637910016775 PS00017 ATP/GTP-binding site motif A (P-loop). 637910016776 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 637910016777 HMMPfam hit to PF06996, Protein of unknown function DUF1305, score 2.3e-14 637910016778 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 637910016779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910016780 Walker A motif; other site 637910016781 ATP binding site [chemical binding]; other site 637910016782 Walker B motif; other site 637910016783 arginine finger; other site 637910016784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910016785 Walker A motif; other site 637910016786 ATP binding site [chemical binding]; other site 637910016787 Walker B motif; other site 637910016788 arginine finger; other site 637910016789 HMMPfam hit to PF02861, Clp, N-terminal, score 2.6e-09 637910016790 HMMPfam hit to PF00004, AAA ATPase, core, score 2.4e-14 637910016791 PS00017 ATP/GTP-binding site motif A (P-loop). 637910016792 PS00870 Chaperonins clpA/B signature 1. 637910016793 HMMPfam hit to PF07724, ATPase AAA-2, score 1.1e-79 637910016794 PS00017 ATP/GTP-binding site motif A (P-loop). 637910016795 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 637910016796 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 637910016797 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 637910016798 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 637910016799 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 637910016800 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016801 HMMPfam hit to PF04524, Rhs element Vgr protein, score 4.3e-54 637910016802 HMMPfam hit to PF06715, Gp5, C-terminal, score 0.00021 637910016803 HMMPfam hit to PF06715, Gp5, C-terminal, score 0.025 637910016804 HMMPfam hit to PF06715, Gp5, C-terminal, score 4.7e-07 637910016805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 637910016806 HMMPfam hit to PF07661, MORN variant, score 0.071 637910016807 HMMPfam hit to PF07661, MORN variant, score 0.48 637910016808 HMMPfam hit to PF07661, MORN variant, score 27 637910016809 HMMPfam hit to PF07661, MORN variant, score 6 637910016810 HsdM N-terminal domain; Region: HsdM_N; pfam12161 637910016811 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 637910016812 Methyltransferase domain; Region: Methyltransf_26; pfam13659 637910016813 HMMPfam hit to PF02384, N-6 DNA methylase, score 2.7e-45 637910016814 PS00092 N-6 Adenine-specific DNA methylases signature. 637910016815 PS00017 ATP/GTP-binding site motif A (P-loop). 637910016816 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 637910016817 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 637910016818 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 637910016819 HMMPfam hit to PF01420, Restriction endonuclease, type I, S subunit, EcoBI, score 1.3e-12 637910016820 PS00017 ATP/GTP-binding site motif A (P-loop). 637910016821 HMMPfam hit to PF01420, Restriction endonuclease, type I, S subunit, EcoBI, score 8.3e-12 637910016822 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 637910016823 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 637910016824 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 637910016825 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 637910016826 ATP binding site [chemical binding]; other site 637910016827 putative Mg++ binding site [ion binding]; other site 637910016828 Predicted helix-turn-helix motif with score 1105.000, SD 2.95 at aa 110-131, sequence FSLCQFKPEHNLNPETLARYKQ 637910016829 HMMPfam hit to PF04313, Restriction endonuclease, type I, EcoRI, R subunit/type III, Res subunit, N terminus, score 2.8e-05 637910016830 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/type III, Res subunit, score 1.7e-06 637910016831 HMMPfam hit to PF00096, Zinc finger, C2H2-type, score 0.015 637910016832 PS00028 Zinc finger, C2H2 type, domain. 637910016833 pseudogene, N-terminus deleted by ISCro1 insertion 637910016834 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910016835 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910016836 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910016837 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910016838 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910016839 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910016840 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910016841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910016842 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910016843 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910016844 Transposase; Region: HTH_Tnp_1; pfam01527 637910016845 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910016846 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910016847 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910016848 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 637910016849 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 637910016850 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637910016851 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 637910016852 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910016853 motif II; other site 637910016854 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 637910016855 HMMPfam hit to PF00689, ATPase, P-type cation-transporter C-terminal, score 8.9e-18 637910016856 10 transmembrane helices predicted for ROD34351 by TMHMM2.0 at aa 72-91, 210-232, 253-275, 290-312, 697-719, 724-746, 769-791, 801-819, 840-862 and 872-889 637910016857 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.2e-26 637910016858 PS00154 E1-E2 ATPases phosphorylation site. 637910016859 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 2.1e-83 637910016860 HMMPfam hit to PF00690, ATPase, P-type cation-transporter N-terminal, score 8e-22 637910016861 1 transmembrane helix predicted for ROD34361 by TMHMM2.0 at aa 52-74 637910016862 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 637910016863 Secretin and TonB N terminus short domain; Region: STN; smart00965 637910016864 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637910016865 N-terminal plug; other site 637910016866 ligand-binding site [chemical binding]; other site 637910016867 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 1.6e-24 637910016868 PS01156 TonB-dependent receptor proteins signature 2. 637910016869 HMMPfam hit to PF07715, TonB-dependent receptor, plug, score 1.3e-17 637910016870 HMMPfam hit to PF07660, Secretin/TonB, short N-terminal, score 9.5e-06 637910016871 pseudogene, fragmented by approx 150 aa deletion and frameshift mutation 637910016872 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 637910016873 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637910016874 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 637910016875 HMMPfam hit to PF08281, RNA polymerase sigma factor 70, region 4 type 2, score 1.4e-15 637910016876 Predicted helix-turn-helix motif with score 1770.000, SD 5.22 at aa 136-157, sequence LTYSDIALRLNVSVSSVKKYVA 637910016877 HMMPfam hit to PF04542, RNA polymerase sigma-70 region 2, score 4.1e-16 637910016878 PS01063 Sigma-70 factors ECF subfamily signature. 637910016879 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 637910016880 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 637910016881 putative [Fe4-S4] binding site [ion binding]; other site 637910016882 putative molybdopterin cofactor binding site [chemical binding]; other site 637910016883 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 637910016884 putative molybdopterin cofactor binding site; other site 637910016885 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 5.5e-05 637910016886 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 6.7e-85 637910016887 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 637910016888 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 5.4e-37 637910016889 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 637910016890 4Fe-4S binding domain; Region: Fer4; pfam00037 637910016891 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016892 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 1.8e-08 637910016893 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910016894 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 637910016895 HMMPfam hit to PF04976, DMSO reductase anchor subunit (DmsC), score 5.7e-11 637910016896 8 transmembrane helices predicted for ROD34421 by TMHMM2.0 at aa 4-26, 33-55, 77-96, 103-125, 135-157, 162-181, 210-232 and 239-261 637910016897 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 637910016898 4Fe-4S binding domain; Region: Fer4; pfam00037 637910016899 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637910016900 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 637910016901 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016902 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 1.2e-07 637910016903 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910016904 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 7.3e-05 637910016905 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 7.6e-06 637910016906 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910016907 2 transmembrane helices predicted for ROD34441 by TMHMM2.0 at aa 19-41 and 56-78 637910016908 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016909 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 637910016910 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 637910016911 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637910016912 2 transmembrane helices predicted for ROD34461 by TMHMM2.0 at aa 9-31 and 238-260 637910016913 HMMPfam hit to PF00563, EAL, score 1.1e-112 637910016914 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 637910016915 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 637910016916 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910016917 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 4.8e-13 637910016918 PS00041 Bacterial regulatory proteins, araC family signature. 637910016919 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 4.9e-10 637910016920 Predicted helix-turn-helix motif with score 1180.000, SD 3.21 at aa 22-43, sequence LNIDVVAKKSGYSKWYLQRMFR 637910016921 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 637910016922 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 637910016923 DNA binding residues [nucleotide binding] 637910016924 dimer interface [polypeptide binding]; other site 637910016925 [2Fe-2S] cluster binding site [ion binding]; other site 637910016926 Predicted helix-turn-helix motif with score 1158.000, SD 3.13 at aa 12-33, sequence LTPGEVAKRSGVAVSALHFYES 637910016927 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 2.1e-12 637910016928 PS00552 Bacterial regulatory proteins, merR family signature. 637910016929 HMMPfam hit to PF09278, Transcription regulator MerR, DNA binding, score 6.9e-19 637910016930 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 637910016931 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 637910016932 putative C-terminal domain interface [polypeptide binding]; other site 637910016933 putative GSH binding site (G-site) [chemical binding]; other site 637910016934 putative dimer interface [polypeptide binding]; other site 637910016935 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 637910016936 putative N-terminal domain interface [polypeptide binding]; other site 637910016937 putative dimer interface [polypeptide binding]; other site 637910016938 putative substrate binding pocket (H-site) [chemical binding]; other site 637910016939 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 9.4e-14 637910016940 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 4.2e-08 637910016941 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 637910016942 HMMPfam hit to PF00860, Xanthine/uracil/vitamin C permease, score 8.8e-112 637910016943 12 transmembrane helices predicted for ROD34501 by TMHMM2.0 at aa 29-51, 56-78, 85-107, 112-134, 141-163, 173-195, 202-224, 244-266, 329-351, 356-378, 391-413 and 428-447 637910016944 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016945 PS00017 ATP/GTP-binding site motif A (P-loop). 637910016946 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 637910016947 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 637910016948 9 transmembrane helices predicted for ROD34511 by TMHMM2.0 at aa 4-26, 86-108, 113-135, 181-203, 233-255, 276-298, 313-335, 361-383 and 398-420 637910016949 HMMPfam hit to PF00999, Sodium/hydrogen exchanger, score 1.3e-81 637910016950 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910016951 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910016952 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 637910016953 putative dimerization interface [polypeptide binding]; other site 637910016954 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.3e-42 637910016955 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 2e-21 637910016956 PS00044 Bacterial regulatory proteins, lysR family signature. 637910016957 Predicted helix-turn-helix motif with score 1880.000, SD 5.59 at aa 16-37, sequence QSFTRAAEKLFVTQPTISKMLK 637910016958 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637910016959 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637910016960 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 637910016961 HMMPfam hit to PF02894, Oxidoreductase, C-terminal, score 2.7e-12 637910016962 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 3.1e-14 637910016963 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016964 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 637910016965 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 637910016966 Na binding site [ion binding]; other site 637910016967 13 transmembrane helices predicted for ROD34551 by TMHMM2.0 at aa 33-55, 76-98, 103-125, 146-168, 183-205, 212-234, 261-283, 303-325, 359-381, 402-424, 428-450, 462-484 and 494-516 637910016968 PS00457 Sodium:solute symporter family signature 2. 637910016969 HMMPfam hit to PF00474, Na+/solute symporter, score 3e-197 637910016970 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910016971 PS00456 Sodium:solute symporter family signature 1. 637910016972 Predicted membrane protein [Function unknown]; Region: COG3162 637910016973 HMMPfam hit to PF04341, Protein of unknown function DUF485, score 4.7e-62 637910016974 2 transmembrane helices predicted for ROD34561 by TMHMM2.0 at aa 25-47 and 62-84 637910016975 acetyl-CoA synthetase; Provisional; Region: PRK00174 637910016976 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 637910016977 active site 637910016978 CoA binding site [chemical binding]; other site 637910016979 acyl-activating enzyme (AAE) consensus motif; other site 637910016980 AMP binding site [chemical binding]; other site 637910016981 acetate binding site [chemical binding]; other site 637910016982 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 2.6e-141 637910016983 PS00455 AMP-binding domain signature. 637910016984 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 637910016985 1 transmembrane helix predicted for ROD34581 by TMHMM2.0 at aa 12-31 637910016986 HMMPfam hit to PF02335, Cytochrome c552, score 0 637910016987 PS00190 Cytochrome c family heme-binding site signature. 637910016988 PS00190 Cytochrome c family heme-binding site signature. 637910016989 PS00190 Cytochrome c family heme-binding site signature. 637910016990 PS00190 Cytochrome c family heme-binding site signature. 637910016991 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 637910016992 PS00190 Cytochrome c family heme-binding site signature. 637910016993 PS00190 Cytochrome c family heme-binding site signature. 637910016994 PS00190 Cytochrome c family heme-binding site signature. 637910016995 PS00190 Cytochrome c family heme-binding site signature. 637910016996 PS00190 Cytochrome c family heme-binding site signature. 637910016997 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 637910016998 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 637910016999 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.00037 637910017000 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 9.1e-06 637910017001 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910017002 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0076 637910017003 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 637910017004 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 637910017005 HMMPfam hit to PF03916, Polysulphide reductase, NrfD, score 9.2e-143 637910017006 8 transmembrane helices predicted for ROD34611 by TMHMM2.0 at aa 15-37, 57-76, 91-113, 151-170, 180-202, 223-242, 252-274 and 287-309 637910017007 heme lyase subunit NrfE; Provisional; Region: PRK10369 637910017008 13 transmembrane helices predicted for ROD34621 by TMHMM2.0 at aa 11-33, 46-68, 101-120, 127-149, 183-205, 212-234, 254-271, 283-305, 315-337, 358-380, 395-414, 426-448 and 551-570 637910017009 HMMPfam hit to PF01578, Cytochrome c assembly protein, score 2.2e-64 637910017010 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910017011 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 637910017012 HMMPfam hit to PF03918, Cytochrome C biogenesis protein, score 2e-39 637910017013 1 transmembrane helix predicted for ROD34631 by TMHMM2.0 at aa 101-123 637910017014 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 637910017015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637910017016 binding surface 637910017017 TPR motif; other site 637910017018 1 transmembrane helix predicted for ROD34641 by TMHMM2.0 at aa 15-34 637910017019 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017020 HMMPfam hit to PF00515, Tetratricopeptide TPR-1, score 0.00021 637910017021 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 637910017022 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 637910017023 8 transmembrane helices predicted for ROD34651 by TMHMM2.0 at aa 7-29, 49-71, 84-106, 160-179, 206-228, 233-255, 354-376 and 391-409 637910017024 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter, score 1.4e-226 637910017025 PS00713 Sodium:dicarboxylate symporter family signature 1. 637910017026 Predicted helix-turn-helix motif with score 1016.000, SD 2.65 at aa 247-268, sequence VVLGIVARLCGLSVWILIRILK 637910017027 PS00714 Sodium:dicarboxylate symporter family signature 2. 637910017028 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 637910017029 Sel1-like repeats; Region: SEL1; smart00671 637910017030 HMMPfam hit to PF08238, Sel1-like, score 0.00068 637910017031 HMMPfam hit to PF08238, Sel1-like, score 0.0033 637910017032 HMMPfam hit to PF08238, Sel1-like, score 0.38 637910017033 HMMPfam hit to PF08238, Sel1-like, score 0.0061 637910017034 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637910017035 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637910017036 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637910017037 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.2e-27 637910017038 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 1.2e-17 637910017039 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 637910017040 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 637910017041 [4Fe-4S] binding site [ion binding]; other site 637910017042 molybdopterin cofactor binding site; other site 637910017043 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 637910017044 molybdopterin cofactor binding site; other site 637910017045 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 3.5e-35 637910017046 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017047 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 637910017048 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1.4e-178 637910017049 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 637910017050 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 7e-22 637910017051 PS00017 ATP/GTP-binding site motif A (P-loop). 637910017052 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 637910017053 D-allose kinase; Provisional; Region: PRK09698 637910017054 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637910017055 nucleotide binding site [chemical binding]; other site 637910017056 HMMPfam hit to PF00480, ROK, score 1.8e-64 637910017057 PS01125 ROK family signature. 637910017058 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 637910017059 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 637910017060 substrate binding site [chemical binding]; other site 637910017061 hexamer interface [polypeptide binding]; other site 637910017062 metal binding site [ion binding]; metal-binding site 637910017063 HMMPfam hit to PF00834, Ribulose-phosphate 3-epimerase, score 2.2e-67 637910017064 PS01086 Ribulose-phosphate 3-epimerase family signature 2. 637910017065 PS01085 Ribulose-phosphate 3-epimerase family signature 1. 637910017066 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637910017067 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637910017068 TM-ABC transporter signature motif; other site 637910017069 9 transmembrane helices predicted for ROD34711 by TMHMM2.0 at aa 26-48, 68-90, 105-127, 134-156, 171-193, 220-242, 252-274, 279-298 and 303-320 637910017070 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 1.1e-82 637910017071 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 637910017072 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637910017073 Walker A/P-loop; other site 637910017074 ATP binding site [chemical binding]; other site 637910017075 Q-loop/lid; other site 637910017076 ABC transporter signature motif; other site 637910017077 Walker B; other site 637910017078 D-loop; other site 637910017079 H-loop/switch region; other site 637910017080 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637910017081 HMMPfam hit to PF00005, ABC transporter related, score 3.4e-28 637910017082 PS00211 ABC transporters family signature. 637910017083 HMMPfam hit to PF00005, ABC transporter related, score 5.3e-50 637910017084 PS00017 ATP/GTP-binding site motif A (P-loop). 637910017085 D-allose transporter subunit; Provisional; Region: PRK09701 637910017086 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 637910017087 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 2.1e-06 637910017088 PS00017 ATP/GTP-binding site motif A (P-loop). 637910017089 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 637910017090 1 transmembrane helix predicted for ROD34731 by TMHMM2.0 at aa 7-29 637910017091 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 637910017092 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637910017093 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 637910017094 putative active site [active] 637910017095 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 4.4e-39 637910017096 HMMPfam hit to PF01418, Helix-turn-helix protein RpiR, score 1.2e-45 637910017097 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 637910017098 HMMPfam hit to PF02502, Ribose/galactose isomerase, score 3.3e-86 637910017099 1 transmembrane helix predicted for ROD34771 by TMHMM2.0 at aa 21-38 637910017100 3 transmembrane helices predicted for ROD34781 by TMHMM2.0 at aa 10-32, 52-74 and 78-97 637910017101 hypothetical protein; Provisional; Region: PRK10220 637910017102 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 637910017103 PhnA protein; Region: PhnA; pfam03831 637910017104 HMMPfam hit to PF03831, PhnA protein, C-terminal, score 5e-37 637910017105 HMMPfam hit to PF08274, PhnA protein, N-terminal, score 5.3e-16 637910017106 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 637910017107 HMMPfam hit to PF03812, 2-keto-3-deoxygluconate permease, score 7.4e-222 637910017108 10 transmembrane helices predicted for ROD34801 by TMHMM2.0 at aa 7-29, 44-62, 75-97, 107-129, 142-164, 168-185, 198-220, 225-244, 251-273 and 283-305 637910017109 proline/glycine betaine transporter; Provisional; Region: PRK10642 637910017110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910017111 putative substrate translocation pore; other site 637910017112 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 637910017113 HMMPfam hit to PF00083, General substrate transporter score 4.2e-95 637910017114 12 transmembrane helices predicted for ROD34811 by TMHMM2.0 at aa 30-52, 67-89, 98-120, 124-146, 167-189, 199-221, 260-282, 297-319, 326-346, 351-373, 386-408 and 418-437 637910017115 PS00216 Sugar transport proteins signature 1. 637910017116 HMMPfam hit to PF08946, Osmosensory transporter coiled coil, score 7e-23 637910017117 sensor protein BasS/PmrB; Provisional; Region: PRK10755 637910017118 HAMP domain; Region: HAMP; pfam00672 637910017119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637910017120 dimer interface [polypeptide binding]; other site 637910017121 phosphorylation site [posttranslational modification] 637910017122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910017123 ATP binding site [chemical binding]; other site 637910017124 Mg2+ binding site [ion binding]; other site 637910017125 G-X-G motif; other site 637910017126 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1e-23 637910017127 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.5e-10 637910017128 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 6.9e-08 637910017129 2 transmembrane helices predicted for ROD34821 by TMHMM2.0 at aa 7-27 and 59-81 637910017130 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 637910017131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910017132 active site 637910017133 phosphorylation site [posttranslational modification] 637910017134 intermolecular recognition site; other site 637910017135 dimerization interface [polypeptide binding]; other site 637910017136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637910017137 DNA binding site [nucleotide binding] 637910017138 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 6.3e-20 637910017139 HMMPfam hit to PF00072, Response regulator receiver, score 3.9e-45 637910017140 PS00217 Sugar transport proteins signature 2. 637910017141 putative metal dependent hydrolase; Provisional; Region: PRK11598 637910017142 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 637910017143 Sulfatase; Region: Sulfatase; pfam00884 637910017144 HMMPfam hit to PF00884, Sulphatase, score 3.7e-81 637910017145 HMMPfam hit to PF08019, Protein of unknown function DUF1705, score 2.1e-70 637910017146 5 transmembrane helices predicted for ROD34841 by TMHMM2.0 at aa 12-34, 49-71, 78-100, 120-142 and 154-176 637910017147 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017148 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017149 fumarate hydratase; Provisional; Region: PRK15389 637910017150 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 637910017151 Fumarase C-terminus; Region: Fumerase_C; pfam05683 637910017152 HMMPfam hit to PF05683, Fe-S type hydro-lyases tartrate/fumarate beta region, score 1.3e-113 637910017153 PS00163 Fumarate lyases signature. 637910017154 HMMPfam hit to PF05681, Fe-S type hydro-lyases tartrate/fumarate alpha region, score 4.4e-144 637910017155 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017156 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 637910017157 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 637910017158 11 transmembrane helices predicted for ROD34861 by TMHMM2.0 at aa 21-43, 53-75, 88-110, 142-164, 171-193, 236-255, 268-290, 305-327, 340-362, 377-399 and 420-442 637910017159 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017160 HMMPfam hit to PF03605, Anaerobic c4-dicarboxylate membrane transporter score 1.8e-254 637910017161 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 637910017162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910017163 active site 637910017164 phosphorylation site [posttranslational modification] 637910017165 intermolecular recognition site; other site 637910017166 dimerization interface [polypeptide binding]; other site 637910017167 Transcriptional regulator; Region: CitT; pfam12431 637910017168 Predicted helix-turn-helix motif with score 1159.000, SD 3.13 at aa 179-200, sequence FSTDELANAVNISRVSCRKYLI 637910017169 HMMPfam hit to PF00072, Response regulator receiver, score 3.4e-25 637910017170 sensory histidine kinase DcuS; Provisional; Region: PRK11086 637910017171 PAS domain; Region: PAS; smart00091 637910017172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910017173 ATP binding site [chemical binding]; other site 637910017174 Mg2+ binding site [ion binding]; other site 637910017175 G-X-G motif; other site 637910017176 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.2e-30 637910017177 HMMPfam hit to PF00989, PAS fold, score 3.7e-18 637910017178 2 transmembrane helices predicted for ROD34881 by TMHMM2.0 at aa 20-42 and 183-202 637910017179 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 637910017180 7 transmembrane helices predicted for ROD34891 by TMHMM2.0 at aa 7-29, 34-56, 63-85, 114-136, 143-165, 234-256 and 286-308 637910017181 HMMPfam hit to PF03824, Nickel/cobalt transporter high-affinity, score 3.1e-31 637910017182 pseudogene, truncated by frameshift mutation 637910017183 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 8.1e-09 637910017184 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 4.6e-102 637910017185 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 8.7e-32 637910017186 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 637910017187 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 6.4e-06 637910017188 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910017189 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 637910017190 HMMPfam hit to PF04976, DMSO reductase anchor subunit (DmsC), score 2.3e-18 637910017191 8 transmembrane helices predicted for ROD34931 by TMHMM2.0 at aa 4-26, 39-61, 81-100, 109-131, 141-163, 166-188, 198-220 and 227-249 637910017192 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 637910017193 HMMPfam hit to PF06192, Cytoplasmic chaperone TorD, score 1.6e-49 637910017194 ferredoxin-type protein NapF; Region: napF; TIGR00402 637910017195 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.002 637910017196 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910017197 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 7.7e-05 637910017198 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 6.1e-05 637910017199 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910017200 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637910017201 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 2.6e-42 637910017202 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637910017203 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 2.3e-17 637910017204 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 637910017205 PapC N-terminal domain; Region: PapC_N; pfam13954 637910017206 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637910017207 PapC C-terminal domain; Region: PapC_C; pfam13953 637910017208 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 1.4e-297 637910017209 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 637910017210 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 637910017211 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637910017212 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637910017213 1 transmembrane helix predicted for ROD34991 by TMHMM2.0 at aa 7-29 637910017214 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 1e-43 637910017215 PS00635 Gram-negative pili assembly chaperone signature. 637910017216 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 3.9e-12 637910017217 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637910017218 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 1.4e-22 637910017219 Fimbrial protein; Region: Fimbrial; cl01416 637910017220 Fimbrial protein; Region: Fimbrial; pfam00419 637910017221 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 0.014 637910017222 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637910017223 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 1.2e-40 637910017224 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570 637910017225 GTPase interaction site; other site 637910017226 Predicted helix-turn-helix motif with score 1015.000, SD 2.64 at aa 176-197, sequence KSLSQISSEVNMDVRRLSYIKR 637910017227 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017228 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 637910017229 catalytic residues [active] 637910017230 hinge region; other site 637910017231 alpha helical domain; other site 637910017232 1 transmembrane helix predicted for ROD35051 by TMHMM2.0 at aa 12-34 637910017233 HMMPfam hit to PF01323, DSBA oxidoreductase, score 2.5e-05 637910017234 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 637910017235 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 637910017236 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 637910017237 putative active site [active] 637910017238 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637910017239 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 637910017240 Walker A/P-loop; other site 637910017241 ATP binding site [chemical binding]; other site 637910017242 Q-loop/lid; other site 637910017243 ABC transporter signature motif; other site 637910017244 Walker B; other site 637910017245 D-loop; other site 637910017246 H-loop/switch region; other site 637910017247 HMMPfam hit to PF03412, Peptidase C39, bacteriocin processing, score 1.5e-23 637910017248 5 transmembrane helices predicted for ROD35071 by TMHMM2.0 at aa 166-188, 203-225, 281-300, 304-323 and 389-411 637910017249 HMMPfam hit to PF00005, ABC transporter related, score 5.8e-44 637910017250 PS00017 ATP/GTP-binding site motif A (P-loop). 637910017251 PS00211 ABC transporters family signature. 637910017252 macrolide transporter subunit MacA; Provisional; Region: PRK11578 637910017253 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637910017254 HlyD family secretion protein; Region: HlyD_3; pfam13437 637910017255 1 transmembrane helix predicted for ROD35081 by TMHMM2.0 at aa 7-29 637910017256 HMMPfam hit to PF00529, Secretion protein HlyD, score 2.2e-12 637910017257 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 637910017258 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 637910017259 Walker A/P-loop; other site 637910017260 ATP binding site [chemical binding]; other site 637910017261 Q-loop/lid; other site 637910017262 ABC transporter signature motif; other site 637910017263 Walker B; other site 637910017264 D-loop; other site 637910017265 H-loop/switch region; other site 637910017266 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 637910017267 FtsX-like permease family; Region: FtsX; pfam02687 637910017268 HMMPfam hit to PF00005, ABC transporter related, score 1.2e-64 637910017269 PS00017 ATP/GTP-binding site motif A (P-loop). 637910017270 PS00211 ABC transporters family signature. 637910017271 4 transmembrane helices predicted for ROD35091 by TMHMM2.0 at aa 266-288, 519-541, 567-589 and 604-626 637910017272 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 8.8e-47 637910017273 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017274 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 637910017275 1 transmembrane helix predicted for ROD35101 by TMHMM2.0 at aa 12-34 637910017276 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017277 HMMPfam hit to PF02321, Outer membrane efflux protein, score 2.3e-24 637910017278 HMMPfam hit to PF02321, Outer membrane efflux protein, score 4.2e-17 637910017279 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 637910017280 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 637910017281 dimer interface [polypeptide binding]; other site 637910017282 active site 637910017283 HMMPfam hit to PF00109, beta-ketoacyl synthase, N-terminal, score 1.9e-34 637910017284 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017285 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017286 PS00606 beta-ketoacyl synthases active site. 637910017287 HMMPfam hit to PF02801, beta-ketoacyl synthase, C-terminal, score 1.4e-38 637910017288 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 637910017289 HMMPfam hit to PF00550, Phosphopantetheine-binding, score 0.00016 637910017290 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 637910017291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637910017292 NAD(P) binding site [chemical binding]; other site 637910017293 active site 637910017294 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 3.4e-33 637910017295 PS00061 Short-chain dehydrogenases/reductases family signature. 637910017296 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637910017297 Zn2+ binding site [ion binding]; other site 637910017298 Mg2+ binding site [ion binding]; other site 637910017299 PS00850 Glycine radical signature. 637910017300 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 2e-05 637910017301 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 637910017302 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910017303 HMMPfam hit to PF01609, Transposase, IS4-like, score 9.3e-30 637910017304 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 637910017305 DNA binding site [nucleotide binding] 637910017306 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 637910017307 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 3.6e-12 637910017308 FaeA-like protein; Region: FaeA; pfam04703 637910017309 HMMPfam hit to PF04703, FaeA-like protein, score 9.2e-05 637910017310 Predicted helix-turn-helix motif with score 1333.000, SD 3.73 at aa 59-80, sequence LSTRELADLCGISIYKVRHLLL 637910017311 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 637910017312 active site 637910017313 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017314 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 637910017315 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 637910017316 HMMPfam hit to PF08843, Protein of unknown function DUF1814, score 3.5e-35 637910017317 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 637910017318 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 637910017319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 637910017320 HMMPfam hit to PF08681, Protein of unknown function DUF1778, score 3.8e-28 637910017321 pseudogene, C-terminus deleted by ISCro1 insertion 637910017322 Transposase; Region: HTH_Tnp_1; pfam01527 637910017323 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910017324 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910017325 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910017326 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910017327 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910017328 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910017329 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910017330 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910017331 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910017332 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910017333 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910017334 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910017335 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910017336 pseudogene, N-terminus deleted by ISCro1 insertion, C-terminal part truncated by frameshift mutation 637910017337 HMMPfam hit to PF04524, Rhs element Vgr protein, score 1.5e-32 637910017338 HMMPfam hit to PF06715, Gp5, C-terminal, score 0.00037 637910017339 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 637910017340 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 637910017341 HMMPfam hit to PF08929, Region of unknown function DUF1911, score 6.2e-27 637910017342 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 637910017343 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 637910017344 HMMPfam hit to PF08929, Region of unknown function DUF1911, score 4.9e-25 637910017345 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 637910017346 CHAP domain; Region: CHAP; pfam05257 637910017347 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 637910017348 HMMPfam hit to PF03738, Glutathionylspermidine synthase, score 1.5e-22 637910017349 HMMPfam hit to PF05257, Cysteine, histidine-dependent amidohydrolase/peptidase, score 3.5e-33 637910017350 1 transmembrane helix predicted for ROD35371 by TMHMM2.0 at aa 66-85 637910017351 pseudogene, fragmented by 100 aa deletion and frameshift mutation 637910017352 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 637910017353 HMMPfam hit to PF01455, Hydrogenase expression/formation protein (HUPF/HYPC), score 1.6e-41 637910017354 PS01097 Hydrogenases expression/synthesis hupF/hypC family signature. 637910017355 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 637910017356 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 637910017357 HMMPfam hit to PF01155, Hydrogenase expression/synthesis, HypA, score 9.1e-61 637910017358 PS01249 Hydrogenases expression/synthesis hypA family signature. 637910017359 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017360 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 637910017361 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 637910017362 putative substrate-binding site; other site 637910017363 nickel binding site [ion binding]; other site 637910017364 HMMPfam hit to PF01750, Peptidase A31, hydrogen uptake protein, score 2.7e-47 637910017365 hydrogenase 2 large subunit; Provisional; Region: PRK10467 637910017366 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 637910017367 HMMPfam hit to PF00374, Nickel-dependent hydrogenase, large subunit, score 0 637910017368 PS00508 Nickel-dependent hydrogenases large subunit signature 2. 637910017369 PS00507 Nickel-dependent hydrogenases large subunit signature 1. 637910017370 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 637910017371 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 637910017372 10 transmembrane helices predicted for ROD35431 by TMHMM2.0 at aa 13-32, 52-74, 86-108, 128-150, 171-193, 208-227, 246-268, 283-302, 315-337 and 352-374 637910017373 HMMPfam hit to PF03916, Polysulphide reductase, NrfD, score 0.0022 637910017374 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017375 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 637910017376 4Fe-4S binding domain; Region: Fer4_6; pfam12837 637910017377 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 4.6e-06 637910017378 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910017379 hydrogenase 2 small subunit; Provisional; Region: PRK10468 637910017380 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 637910017381 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 637910017382 1 transmembrane helix predicted for ROD35451 by TMHMM2.0 at aa 332-354 637910017383 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 kDa subunit, score 7.9e-05 637910017384 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017385 HMMPfam hit to PF08425, NiFe dehydrogenase small subunit, N-terminal, score 1.5e-45 637910017386 pseudogene, fragmented by 225 aa deletion and two frameshift mutations 637910017387 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 9.7e-97 637910017388 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637910017389 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637910017390 active site 637910017391 catalytic tetrad [active] 637910017392 HMMPfam hit to PF00248, Aldo/keto reductase, score 5.2e-85 637910017393 hypothetical protein; Provisional; Region: PRK05208 637910017394 3 transmembrane helices predicted for ROD35491 by TMHMM2.0 at aa 10-32, 53-75 and 136-155 637910017395 HMMPfam hit to PF03350, Protein of unknown function UPF0114, score 1.3e-56 637910017396 1 transmembrane helix predicted for ROD35501 by TMHMM2.0 at aa 4-23 637910017397 oxidoreductase; Provisional; Region: PRK07985 637910017398 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 637910017399 NAD binding site [chemical binding]; other site 637910017400 metal binding site [ion binding]; metal-binding site 637910017401 active site 637910017402 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 7.9e-17 637910017403 PS00061 Short-chain dehydrogenases/reductases family signature. 637910017404 biopolymer transport protein ExbD; Provisional; Region: PRK11267 637910017405 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 637910017406 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 1.9e-21 637910017407 1 transmembrane helix predicted for ROD35541 by TMHMM2.0 at aa 20-42 637910017408 biopolymer transport protein ExbB; Provisional; Region: PRK10414 637910017409 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel, score 9.6e-53 637910017410 3 transmembrane helices predicted for ROD35551 by TMHMM2.0 at aa 20-42, 131-153 and 177-199 637910017411 cystathionine beta-lyase; Provisional; Region: PRK08114 637910017412 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 637910017413 homodimer interface [polypeptide binding]; other site 637910017414 substrate-cofactor binding pocket; other site 637910017415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910017416 catalytic residue [active] 637910017417 HMMPfam hit to PF01053, Cys/Met metabolism, pyridoxal phosphate-dependent enzyme, score 5.2e-171 637910017418 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 637910017419 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 637910017420 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 637910017421 4 transmembrane helices predicted for ROD35571 by TMHMM2.0 at aa 24-46, 66-88, 158-180 and 190-212 637910017422 HMMPfam hit to PF09335, SNARE associated Golgi protein, score 1.1e-05 637910017423 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017424 pseudogene, truncated by premature stop codon 637910017425 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 1.9e-05 637910017426 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 0.00017 637910017427 HMMPfam hit to PF06719, AraC-type transcriptional regulator, N-terminal, score 4.6e-71 637910017428 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 637910017429 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 637910017430 dimer interface [polypeptide binding]; other site 637910017431 active site 637910017432 metal binding site [ion binding]; metal-binding site 637910017433 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 2.1e-13 637910017434 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 637910017435 PS00913 Iron-containing alcohol dehydrogenases signature 1. 637910017436 PS00060 Iron-containing alcohol dehydrogenases signature 2. 637910017437 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 637910017438 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 637910017439 active site 637910017440 catalytic tetrad [active] 637910017441 HMMPfam hit to PF00248, Aldo/keto reductase, score 3.8e-122 637910017442 PS00798 Aldo/keto reductase family signature 1. 637910017443 PS00062 Aldo/keto reductase family signature 2. 637910017444 Predicted helix-turn-helix motif with score 1017.000, SD 2.65 at aa 200-221, sequence KIIRDLADKYGKTPAQIVIRWH 637910017445 PS00063 Aldo/keto reductase family active site signature. 637910017446 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 637910017447 hypothetical protein; Provisional; Region: PRK01254 637910017448 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 637910017449 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 637910017450 HMMPfam hit to PF04055, Radical SAM, score 3e-12 637910017451 PS01278 Uncharacterized protein family UPF0004 signature. 637910017452 HMMPfam hit to PF08497, Radical SAM N-terminal, score 7.1e-276 637910017453 FtsI repressor; Provisional; Region: PRK10883 637910017454 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 637910017455 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 637910017456 HMMPfam hit to PF07731, Multicopper oxidase, type 2, score 8.5e-18 637910017457 HMMPfam hit to PF07732, Multicopper oxidase, type 3, score 8.4e-40 637910017458 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 637910017459 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 637910017460 putative acyl-acceptor binding pocket; other site 637910017461 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 637910017462 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 8.5e-50 637910017463 1 transmembrane helix predicted for ROD35641 by TMHMM2.0 at aa 2-24 637910017464 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 637910017465 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 637910017466 CAP-like domain; other site 637910017467 active site 637910017468 primary dimer interface [polypeptide binding]; other site 637910017469 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 637910017470 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 2.1e-08 637910017471 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 6.9e-05 637910017472 HMMPfam hit to PF00521, DNA topoisomerase, type IIA, subunit A or C-terminal, score 1.3e-270 637910017473 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 637910017474 HMMPfam hit to PF04076, Conserved hypothetical protein CHP00156, score 2.5e-69 637910017475 1 transmembrane helix predicted for ROD35661 by TMHMM2.0 at aa 15-37 637910017476 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 637910017477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910017478 active site 637910017479 phosphorylation site [posttranslational modification] 637910017480 intermolecular recognition site; other site 637910017481 dimerization interface [polypeptide binding]; other site 637910017482 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637910017483 DNA binding site [nucleotide binding] 637910017484 HMMPfam hit to PF00072, Response regulator receiver, score 3e-32 637910017485 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1.8e-22 637910017486 sensor protein QseC; Provisional; Region: PRK10337 637910017487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637910017488 dimer interface [polypeptide binding]; other site 637910017489 phosphorylation site [posttranslational modification] 637910017490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910017491 ATP binding site [chemical binding]; other site 637910017492 Mg2+ binding site [ion binding]; other site 637910017493 G-X-G motif; other site 637910017494 2 transmembrane helices predicted for ROD35681 by TMHMM2.0 at aa 7-29 and 158-180 637910017495 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 1.3e-05 637910017496 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 3.2e-15 637910017497 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.4e-28 637910017498 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 637910017499 HMMPfam hit to PF02525, Flavodoxin-like fold, score 6.9e-81 637910017500 Uncharacterized conserved protein [Function unknown]; Region: COG1359 637910017501 HMMPfam hit to PF03992, Antibiotic biosynthesis monooxygenase, score 2.5e-14 637910017502 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 637910017503 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 637910017504 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637910017505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910017506 homodimer interface [polypeptide binding]; other site 637910017507 catalytic residue [active] 637910017508 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 8.3e-23 637910017509 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 637910017510 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 637910017511 HMMPfam hit to PF07470, Glycosyl hydrolase, family 88, score 2.1e-35 637910017512 pseudogene, truncated by frameshift mutation 637910017513 HMMPfam hit to PF01306, Proton/sugar symporter, LacY, score 4.2e-94 637910017514 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 637910017515 Cupin domain; Region: Cupin_2; cl17218 637910017516 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 637910017517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910017518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910017519 HMMPfam hit to PF02311, AraC protein, arabinose-binding/dimerisation, score 1.4e-07 637910017520 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 6.1e-09 637910017521 Predicted helix-turn-helix motif with score 1425.000, SD 4.04 at aa 196-217, sequence FRLDALAAEIGKSKSYVSRRFH 637910017522 PS00041 Bacterial regulatory proteins, araC family signature. 637910017523 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 1.5e-09 637910017524 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 637910017525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910017526 ATP binding site [chemical binding]; other site 637910017527 Mg2+ binding site [ion binding]; other site 637910017528 G-X-G motif; other site 637910017529 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 637910017530 anchoring element; other site 637910017531 dimer interface [polypeptide binding]; other site 637910017532 ATP binding site [chemical binding]; other site 637910017533 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 637910017534 active site 637910017535 metal binding site [ion binding]; metal-binding site 637910017536 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 637910017537 HMMPfam hit to PF00986, DNA topoisomerase, type IIA, subunit B, C-terminal, score 5.9e-33 637910017538 PS00177 DNA topoisomerase II signature. 637910017539 HMMPfam hit to PF00204, DNA topoisomerase, type IIA, subunit B, region 2, score 4.9e-59 637910017540 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 3.9e-25 637910017541 esterase YqiA; Provisional; Region: PRK11071 637910017542 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 637910017543 HMMPfam hit to PF05728, Protein of unknown function UPF0227, score 8.1e-105 637910017544 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 637910017545 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 637910017546 active site 637910017547 metal binding site [ion binding]; metal-binding site 637910017548 hexamer interface [polypeptide binding]; other site 637910017549 HMMPfam hit to PF08413, Calcineurin-like phosphoesterase C-terminal, score 7.3e-43 637910017550 HMMPfam hit to PF00149, Metallophosphoesterase, score 3.3e-18 637910017551 putative dehydrogenase; Provisional; Region: PRK11039 637910017552 HMMPfam hit to PF06853, Protein of unknown function DUF1249, score 4.4e-95 637910017553 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 637910017554 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 637910017555 dimer interface [polypeptide binding]; other site 637910017556 ADP-ribose binding site [chemical binding]; other site 637910017557 active site 637910017558 nudix motif; other site 637910017559 metal binding site [ion binding]; metal-binding site 637910017560 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 1.2e-23 637910017561 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 637910017562 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.1e-44 637910017563 HMMPfam hit to PF02321, Outer membrane efflux protein, score 5.7e-53 637910017564 hypothetical protein; Provisional; Region: PRK11653 637910017565 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017566 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 637910017567 HMMPfam hit to PF03738, Glutathionylspermidine synthase, score 6.8e-270 637910017568 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 637910017569 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 637910017570 putative active site [active] 637910017571 metal binding site [ion binding]; metal-binding site 637910017572 HMMPfam hit to PF02900, Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B, score 7.9e-97 637910017573 zinc transporter ZupT; Provisional; Region: PRK04201 637910017574 6 transmembrane helices predicted for ROD35861 by TMHMM2.0 at aa 5-25, 32-54, 64-81, 169-191, 195-217 and 234-256 637910017575 HMMPfam hit to PF02535, Zinc/iron permease, score 5.3e-50 637910017576 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 637910017577 1 transmembrane helix predicted for ROD35871 by TMHMM2.0 at aa 9-31 637910017578 HMMPfam hit to PF05935, Arylsulphotransferase, score 0 637910017579 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 637910017580 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 637910017581 catalytic residues [active] 637910017582 hinge region; other site 637910017583 alpha helical domain; other site 637910017584 HMMPfam hit to PF01323, DSBA oxidoreductase, score 7.4e-06 637910017585 putative disulfide oxidoreductase; Provisional; Region: PRK04307 637910017586 4 transmembrane helices predicted for ROD35891 by TMHMM2.0 at aa 27-49, 59-78, 83-105 and 200-222 637910017587 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017588 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 637910017589 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 637910017590 HMMPfam hit to PF00926, 3,4-Dihydroxy-2-butanone 4-phosphate synthase, score 3.2e-129 637910017591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 637910017592 HMMPfam hit to PF04380, Protein of unknown function DUF526, score 2.3e-48 637910017593 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 637910017594 HMMPfam hit to PF08971, Glycogen synthesis protein, score 1.2e-49 637910017595 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 637910017596 HMMPfam hit to PF07290, Protein of unknown function DUF1449, score 1.6e-129 637910017597 3 transmembrane helices predicted for ROD35931 by TMHMM2.0 at aa 13-35, 63-85 and 98-117 637910017598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 637910017599 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 637910017600 1 transmembrane helix predicted for ROD35941 by TMHMM2.0 at aa 7-29 637910017601 HMMPfam hit to PF01145, Band 7 protein, score 2.3e-41 637910017602 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 637910017603 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 637910017604 putative ribose interaction site [chemical binding]; other site 637910017605 putative ADP binding site [chemical binding]; other site 637910017606 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 637910017607 active site 637910017608 nucleotide binding site [chemical binding]; other site 637910017609 HIGH motif; other site 637910017610 KMSKS motif; other site 637910017611 HMMPfam hit to PF01467, Cytidylyltransferase, score 5.3e-23 637910017612 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 2.7e-64 637910017613 PS00583 pfkB family of carbohydrate kinases signature 1. 637910017614 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 637910017615 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 637910017616 metal binding triad; other site 637910017617 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 637910017618 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 637910017619 metal binding triad; other site 637910017620 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 637910017621 HMMPfam hit to PF03710, Glutamate-ammonia ligase adenylyltransferase, score 3e-153 637910017622 HMMPfam hit to PF03710, Glutamate-ammonia ligase adenylyltransferase, score 1.8e-127 637910017623 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637910017624 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637910017625 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637910017626 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.2e-27 637910017627 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 1.2e-17 637910017628 Uncharacterized conserved protein [Function unknown]; Region: COG3025 637910017629 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 637910017630 putative active site [active] 637910017631 putative metal binding residues [ion binding]; other site 637910017632 signature motif; other site 637910017633 putative triphosphate binding site [ion binding]; other site 637910017634 HMMPfam hit to PF05235, CHAD, score 6.6e-37 637910017635 Predicted helix-turn-helix motif with score 1221.000, SD 3.35 at aa 187-208, sequence GSLSKAARGYHLAQGNVRREIK 637910017636 HMMPfam hit to PF01928, Adenylate cyclase, score 2.6e-65 637910017637 SH3 domain-containing protein; Provisional; Region: PRK10884 637910017638 Bacterial SH3 domain homologues; Region: SH3b; smart00287 637910017639 HMMPfam hit to PF08239, SH3, type 3, score 0.003 637910017640 1 transmembrane helix predicted for ROD35991 by TMHMM2.0 at aa 167-189 637910017641 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 637910017642 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 637910017643 active site 637910017644 NTP binding site [chemical binding]; other site 637910017645 metal binding triad [ion binding]; metal-binding site 637910017646 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 637910017647 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637910017648 Zn2+ binding site [ion binding]; other site 637910017649 Mg2+ binding site [ion binding]; other site 637910017650 HMMPfam hit to PF01743, Polynucleotide adenylyltransferase region, score 3e-55 637910017651 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 8.1e-18 637910017652 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 637910017653 aromatic chitin/cellulose binding site residues [chemical binding]; other site 637910017654 Glyco_18 domain; Region: Glyco_18; smart00636 637910017655 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 637910017656 active site 637910017657 HMMPfam hit to PF00704, Glycoside hydrolase, family 18, catalytic domain, score 2.9e-90 637910017658 PS01095 Chitinases family 18 active site. 637910017659 HMMPfam hit to PF02839, Carbohydrate-binding family V/XII, score 0.0008 637910017660 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 637910017661 7 transmembrane helices predicted for ROD36021 by TMHMM2.0 at aa 13-35, 50-69, 90-109, 119-136, 187-209, 224-246 and 253-272 637910017662 HMMPfam hit to PF02673, Bacitracin resistance protein BacA, score 8.9e-154 637910017663 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 637910017664 homooctamer interface [polypeptide binding]; other site 637910017665 active site 637910017666 HMMPfam hit to PF02152, Dihydroneopterin aldolase, score 6.1e-51 637910017667 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 637910017668 5 transmembrane helices predicted for ROD36041 by TMHMM2.0 at aa 4-26, 53-75, 80-102, 109-131 and 136-158 637910017669 HMMPfam hit to PF02660, Protein of unknown function DUF205, score 7.8e-106 637910017670 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017671 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017672 transcriptional activator TtdR; Provisional; Region: PRK09801 637910017673 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910017674 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 637910017675 putative effector binding pocket; other site 637910017676 putative dimerization interface [polypeptide binding]; other site 637910017677 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.9e-37 637910017678 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 8.4e-15 637910017679 PS00044 Bacterial regulatory proteins, lysR family signature. 637910017680 Predicted helix-turn-helix motif with score 1192.000, SD 3.25 at aa 21-42, sequence GSFSAAAAALGQTPAFVTKRIQ 637910017681 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 637910017682 HMMPfam hit to PF05681, Fe-S type hydro-lyases tartrate/fumarate alpha region, score 1.7e-146 637910017683 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017684 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 637910017685 HMMPfam hit to PF05683, Fe-S type hydro-lyases tartrate/fumarate beta region, score 6.1e-36 637910017686 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 637910017687 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 637910017688 transmembrane helices; other site 637910017689 HMMPfam hit to PF00939, Sodium/sulphate symporter, score 4.7e-271 637910017690 12 transmembrane helices predicted for ROD36081 by TMHMM2.0 at aa 7-29, 33-50, 52-74, 94-116, 137-154, 192-214, 235-257, 306-328, 341-363, 378-400, 420-442 and 462-484 637910017691 UreD urease accessory protein; Region: UreD; cl00530 637910017692 HMMPfam hit to PF01774, Urease accessory protein UreD, score 2.1e-68 637910017693 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 637910017694 alpha-gamma subunit interface [polypeptide binding]; other site 637910017695 beta-gamma subunit interface [polypeptide binding]; other site 637910017696 HMMPfam hit to PF00547, Urease, gamma subunit region, score 1.3e-77 637910017697 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 637910017698 gamma-beta subunit interface [polypeptide binding]; other site 637910017699 alpha-beta subunit interface [polypeptide binding]; other site 637910017700 HMMPfam hit to PF00699, Urease, beta subunit, score 1e-63 637910017701 urease subunit alpha; Reviewed; Region: ureC; PRK13207 637910017702 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 637910017703 subunit interactions [polypeptide binding]; other site 637910017704 active site 637910017705 flap region; other site 637910017706 HMMPfam hit to PF00449, Urease alpha-subunit, N-terminal, score 2.8e-87 637910017707 HMMPfam hit to PF01979, Amidohydrolase 1, score 1.6e-102 637910017708 PS01120 Urease nickel ligands signature. 637910017709 PS00145 Urease active site. 637910017710 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 637910017711 UreE urease accessory protein, C-terminal domain; Region: UreE_C; pfam05194 637910017712 HMMPfam hit to PF02814, UreE urease accessory, N-terminal, score 3.1e-07 637910017713 HMMPfam hit to PF05194, UreE urease accessory, C-terminal, score 7.2e-33 637910017714 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 637910017715 UreF; Region: UreF; pfam01730 637910017716 HMMPfam hit to PF01730, Urease accessory protein UreF, score 1.1e-56 637910017717 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 637910017718 HMMPfam hit to PF02492, Cobalamin (vitamin B12) biosynthesis CobW-like, score 3.4e-78 637910017719 PS00017 ATP/GTP-binding site motif A (P-loop). 637910017720 UGMP family protein; Validated; Region: PRK09604 637910017721 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 637910017722 HMMPfam hit to PF00814, Peptidase M22, glycoprotease, score 1.7e-73 637910017723 PS01016 Glycoprotease family signature. 637910017724 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 637910017725 HMMPfam hit to PF01165, Ribosomal protein S21, score 2.7e-35 637910017726 PS01181 Ribosomal protein S21 signature. 637910017727 DNA primase; Validated; Region: dnaG; PRK05667 637910017728 CHC2 zinc finger; Region: zf-CHC2; pfam01807 637910017729 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 637910017730 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 637910017731 active site 637910017732 metal binding site [ion binding]; metal-binding site 637910017733 interdomain interaction site; other site 637910017734 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 637910017735 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 637910017736 HMMPfam hit to PF01807, Zinc finger, CHC2-type, score 2.5e-67 637910017737 HMMPfam hit to PF08275, DNA primase catalytic core, N-terminal, score 1.1e-64 637910017738 HMMPfam hit to PF01751, TOPRIM, score 2.7e-25 637910017739 HMMPfam hit to PF08278, DNA primase DnaG, DnaB-binding, score 3.5e-60 637910017740 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 637910017741 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 637910017742 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 637910017743 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 637910017744 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637910017745 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 637910017746 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637910017747 DNA binding residues [nucleotide binding] 637910017748 HMMPfam hit to PF03979, RNA polymerase sigma factor 70, region 1.1, score 3.5e-43 637910017749 HMMPfam hit to PF00140, RNA polymerase sigma-70 region 1.2, score 2.7e-15 637910017750 HMMPfam hit to PF04546, RNA polymerase sigma factor 70, non-essential region, score 5e-124 637910017751 HMMPfam hit to PF04542, RNA polymerase sigma-70 region 2, score 2e-28 637910017752 PS00715 Sigma-70 factors family signature 1. 637910017753 HMMPfam hit to PF04539, RNA polymerase sigma-70 region 3, score 2.3e-41 637910017754 HMMPfam hit to PF04545, RNA polymerase sigma-70 region 4, score 1.1e-24 637910017755 Predicted helix-turn-helix motif with score 1917.000, SD 5.72 at aa 572-593, sequence HTLEEVGKQFDVTRERIRQIEA 637910017756 PS00716 Sigma-70 factors family signature 2. 637910017757 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 637910017758 active site 637910017759 SUMO-1 interface [polypeptide binding]; other site 637910017760 HMMPfam hit to PF03167, Uracil-DNA glycosylase superfamily, score 2.1e-24 637910017761 pseudogene, C-terminus deleted by ISCro1 insertion 637910017762 HMMPfam hit to PF01797, Transposase IS200-like, score 6.3e-68 637910017763 Transposase; Region: HTH_Tnp_1; pfam01527 637910017764 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910017765 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910017766 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910017767 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910017768 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910017769 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910017770 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910017771 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910017772 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910017773 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910017774 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910017775 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910017776 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910017777 pseudogene, truncated by frameshift mutation 637910017778 HMMPfam hit to PF01609, Transposase, IS4-like, score 3.5e-20 637910017779 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 637910017780 Ligand Binding Site [chemical binding]; other site 637910017781 HMMPfam hit to PF00582, UspA, score 8.8e-16 637910017782 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 637910017783 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 637910017784 putative active site [active] 637910017785 putative NTP binding site [chemical binding]; other site 637910017786 putative nucleic acid binding site [nucleotide binding]; other site 637910017787 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 637910017788 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 637910017789 Type II intron maturase; Region: Intron_maturas2; pfam01348 637910017790 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 637910017791 active site 637910017792 PS00190 Cytochrome c family heme-binding site signature. 637910017793 HMMPfam hit to PF01348, Intron maturase, type II, score 1.9e-06 637910017794 Predicted helix-turn-helix motif with score 1012.000, SD 2.63 at aa 495-516, sequence MSRTKIARRLRQADGRYVYWEN 637910017795 HMMPfam hit to PF00078, RNA-directed DNA polymerase (reverse transcriptase), score 1.5e-70 637910017796 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 637910017797 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 637910017798 dimer interface [polypeptide binding]; other site 637910017799 ssDNA binding site [nucleotide binding]; other site 637910017800 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637910017801 HMMPfam hit to PF00436, Primosome PriB/single-strand DNA-binding, score 3e-38 637910017802 PS00736 Single-strand binding protein family signature 2. 637910017803 PS00735 Single-strand binding protein family signature 1. 637910017804 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 637910017805 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 637910017806 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 637910017807 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 637910017808 PS00017 ATP/GTP-binding site motif A (P-loop). 637910017809 PS00211 ABC transporters family signature. 637910017810 HMMPfam hit to PF00005, ABC transporter related, score 3.5e-44 637910017811 PS00017 ATP/GTP-binding site motif A (P-loop). 637910017812 PS00211 ABC transporters family signature. 637910017813 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 637910017815 HMMPfam hit to PF04237, Protein of unknown function DUF419, score 2.4e-51 637910017816 Uncharacterized conserved protein [Function unknown]; Region: COG0432 637910017817 HMMPfam hit to PF01894, Protein of unknown function UPF0047, score 1.8e-59 637910017818 acid phosphatase/phosphotransferase; Provisional; Region: aphA; PRK11009 637910017819 HMMPfam hit to PF03767, Acid phosphatase (Class B), score 1.6e-48 637910017820 PS00215 Mitochondrial energy transfer proteins signature. 637910017821 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 637910017822 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637910017823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910017824 homodimer interface [polypeptide binding]; other site 637910017825 catalytic residue [active] 637910017826 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 3.1e-125 637910017827 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 637910017828 alanine racemase; Reviewed; Region: alr; PRK00053 637910017829 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 637910017830 active site 637910017831 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637910017832 substrate binding site [chemical binding]; other site 637910017833 catalytic residues [active] 637910017834 dimer interface [polypeptide binding]; other site 637910017835 HMMPfam hit to PF00842, Alanine racemase, C-terminal, score 1.2e-69 637910017836 HMMPfam hit to PF01168, Alanine racemase, N-terminal, score 2.8e-97 637910017837 PS00395 Alanine racemase pyridoxal-phosphate attachment site. 637910017838 replicative DNA helicase; Provisional; Region: PRK08006 637910017839 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 637910017840 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 637910017841 Walker A motif; other site 637910017842 ATP binding site [chemical binding]; other site 637910017843 Walker B motif; other site 637910017844 DNA binding loops [nucleotide binding] 637910017845 HMMPfam hit to PF03796, DNA helicase, DnaB-like, C-terminal, score 5.9e-138 637910017846 Predicted helix-turn-helix motif with score 1279.000, SD 3.54 at aa 366-387, sequence RSLKALAKELQVPVVALSQLNR 637910017847 PS00017 ATP/GTP-binding site motif A (P-loop). 637910017848 HMMPfam hit to PF00772, DNA helicase, DnaB-like, N-terminal, score 6.6e-58 637910017849 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 637910017850 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 637910017851 NADP binding site [chemical binding]; other site 637910017852 dimer interface [polypeptide binding]; other site 637910017853 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 2.6e-23 637910017854 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 2e-37 637910017855 PS01162 Quinone oxidoreductase / zeta-crystallin signature. 637910017856 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017857 Phage shock protein G (Phageshock_PspG); Region: Phageshock_PspG; cl11511 637910017858 2 transmembrane helices predicted for ROD36411 by TMHMM2.0 at aa 7-29 and 39-61 637910017859 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 637910017860 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 637910017861 FMN binding site [chemical binding]; other site 637910017862 active site 637910017863 catalytic residues [active] 637910017864 substrate binding site [chemical binding]; other site 637910017865 HMMPfam hit to PF01207, Dihydrouridine synthase, DuS, score 8.6e-144 637910017866 PS01136 Uncharacterized protein family UPF0034 signature. 637910017867 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 637910017868 HMMPfam hit to PF05973, Protein of unknown function DUF891, score 5e-17 637910017869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637910017870 non-specific DNA binding site [nucleotide binding]; other site 637910017871 salt bridge; other site 637910017872 sequence-specific DNA binding site [nucleotide binding]; other site 637910017873 Predicted helix-turn-helix motif with score 2120.000, SD 6.41 at aa 43-64, sequence LTQEQAAKLLGMTQPKLSNMLR 637910017874 pseudogene, disrupted by prophage CRP38 insertion 637910017875 prophage CRP38 637910017876 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 637910017877 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 637910017878 Double zinc ribbon; Region: DZR; pfam12773 637910017879 2 transmembrane helices predicted for ROD36471 by TMHMM2.0 at aa 38-60 and 83-105 637910017880 Hok/gef family; Region: HOK_GEF; pfam01848 637910017881 1 transmembrane helix predicted for ROD36481 by TMHMM2.0 at aa 5-27 637910017882 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 637910017883 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 637910017884 HMMPfam hit to PF04606, Phage transcriptional activator, Ogr/Delta, score 1.3e-12 637910017885 tail protein; Provisional; Region: D; PHA02561 637910017886 HMMPfam hit to PF05954, Phage late control D, score 2.3e-151 637910017887 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 637910017888 HMMPfam hit to PF04984, Phage tail sheath protein, score 4e-87 637910017889 Phage tail tube protein FII; Region: Phage_tube; cl01390 637910017890 HMMPfam hit to PF04985, Phage major tail tube protein, score 4.4e-51 637910017891 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 637910017892 HMMPfam hit to PF06158, Phage tail E, score 2.8e-44 637910017893 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 637910017894 HMMPfam hit to PF06528, Phage P2 GpE, score 6.3e-23 637910017895 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 637910017896 PS00215 Mitochondrial energy transfer proteins signature. 637910017897 3 transmembrane helices predicted for ROD36551 by TMHMM2.0 at aa 529-551, 558-580 and 590-612 637910017898 Predicted helix-turn-helix motif with score 974.000, SD 2.50 at aa 642-663, sequence ERFGPVFDAVGSGISQVFNWFK 637910017899 Phage protein U [General function prediction only]; Region: COG3499 637910017900 HMMPfam hit to PF06995, Phage P2 GpU, score 8.8e-76 637910017901 multiple promoter invertase; Provisional; Region: mpi; PRK13413 637910017902 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 637910017903 catalytic residues [active] 637910017904 catalytic nucleophile [active] 637910017905 Presynaptic Site I dimer interface [polypeptide binding]; other site 637910017906 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 637910017907 Synaptic Flat tetramer interface [polypeptide binding]; other site 637910017908 Synaptic Site I dimer interface [polypeptide binding]; other site 637910017909 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637910017910 DNA-binding interface [nucleotide binding]; DNA binding site 637910017911 HMMPfam hit to PF02796, Resolvase, helix-turn-helix region, score 1.8e-12 637910017912 Predicted helix-turn-helix motif with score 1793.000, SD 5.29 at aa 159-180, sequence HDRKQLAIIYGIGTSTIYRYHP 637910017913 HMMPfam hit to PF00239, Resolvase, N-terminal, score 6.6e-73 637910017914 PS00398 Site-specific recombinases signature 2. 637910017915 PS00397 Site-specific recombinases active site. 637910017916 invertible tail fibre region of prophage CRP38 637910017917 C-terminal region of tail fibre, alternative tail fibre tip, contains inverted repeat sequence found in tail fibre ROD36611 637910017918 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 637910017919 HMMPfam hit to PF02413, Phage tail assembly chaperone gp38, score 1.1e-56 637910017920 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 637910017921 HMMPfam hit to PF02413, Phage tail assembly chaperone gp38, score 5.9e-58 637910017922 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 637910017923 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 637910017924 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 637910017925 PS00687 Aldehyde dehydrogenases glutamic acid active site. 637910017926 HMMPfam hit to PF03406, Phage tail fiber repeat 2, score 9.1e-18 637910017927 HMMPfam hit to PF03406, Phage tail fiber repeat 2, score 7.7e-17 637910017928 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 637910017929 Baseplate J-like protein; Region: Baseplate_J; cl01294 637910017930 HMMPfam hit to PF04865, Phage baseplate assembly predicted J-like, score 1.1e-69 637910017931 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 637910017932 HMMPfam hit to PF04965, GPW/gp25, score 7.3e-22 637910017933 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 637910017934 HMMPfam hit to PF04717, Phage baseplate assembly protein V, score 7.5e-30 637910017935 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 637910017936 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 637910017937 HMMPfam hit to PF05069, Phage virion morphogenesis ( tail completion) protein, score 2.7e-08 637910017938 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 637910017939 HMMPfam hit to PF06891, P2 phage tail completion R, score 1.8e-27 637910017940 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 637910017941 1 transmembrane helix predicted for ROD36691 by TMHMM2.0 at aa 4-26 637910017942 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 637910017943 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 637910017944 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 637910017945 HMMPfam hit to PF05838, Protein of unknown function DUF847, score 3.5e-94 637910017946 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 637910017947 2 transmembrane helices predicted for ROD36711 by TMHMM2.0 at aa 13-35 and 48-70 637910017948 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017949 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 637910017950 HMMPfam hit to PF05489, Phage tail protein X, score 2.1e-20 637910017951 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 637910017952 HMMPfam hit to PF05926, Phage head completion, score 2.5e-40 637910017953 terminase endonuclease subunit; Provisional; Region: M; PHA02537 637910017954 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 637910017955 HMMPfam hit to PF05944, Phage small terminase subunit, score 4e-41 637910017956 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 637910017957 HMMPfam hit to PF05125, Phage major capsid protein, P2, score 6.4e-125 637910017958 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 637910017959 HMMPfam hit to PF05929, Phage capsid scaffolding, score 3.8e-60 637910017960 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 637910017961 terminase ATPase subunit; Provisional; Region: P; PHA02535 637910017962 HMMPfam hit to PF06056, terminase ATPase subunit, score 1.1e-33 637910017963 Predicted helix-turn-helix motif with score 1902.000, SD 5.66 at aa 19-40, sequence YPPAEISRLMGINPNTIYAWKK 637910017964 HMMPfam hit to PF03237, Terminase-like, score 4e-122 637910017965 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910017966 Phage-related protein [Function unknown]; Region: COG4695; cl01923 637910017967 Phage portal protein; Region: Phage_portal; pfam04860 637910017968 HMMPfam hit to PF04860, Phage portal protein, score 1.2e-50 637910017969 1 transmembrane helix predicted for ROD36801 by TMHMM2.0 at aa 15-37 637910017970 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 637910017971 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 637910017972 Mg binding site [ion binding]; other site 637910017973 nucleotide binding site [chemical binding]; other site 637910017974 putative protofilament interface [polypeptide binding]; other site 637910017975 HMMPfam hit to PF06406, StbA, score 2.5e-236 637910017976 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 637910017977 HMMPfam hit to PF05840, Bacteriophage replication gene A, score 8.8e-148 637910017978 Ash protein family; Region: Phage_ASH; pfam10554 637910017979 Predicted helix-turn-helix motif with score 1507.000, SD 4.32 at aa 85-106, sequence KTIRELANELGRSPSTVELNLR 637910017980 PS00037 Myb DNA-binding domain repeat signature 1. 637910017981 Transcriptional regulators [Transcription]; Region: MarR; COG1846 637910017982 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 637910017983 putative DNA binding site [nucleotide binding]; other site 637910017984 putative Zn2+ binding site [ion binding]; other site 637910017985 2 transmembrane helices predicted for ROD36961 by TMHMM2.0 at aa 5-24 and 45-67 637910017986 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 637910017987 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637910017988 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637910017989 non-specific DNA binding site [nucleotide binding]; other site 637910017990 salt bridge; other site 637910017991 sequence-specific DNA binding site [nucleotide binding]; other site 637910017992 integrase; Provisional; Region: int; PHA02601 637910017993 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637910017994 active site 637910017995 DNA binding site [nucleotide binding] 637910017996 Int/Topo IB signature motif; other site 637910017997 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 3.3e-33 637910017998 ferric uptake regulator; Provisional; Region: fur; PRK09462 637910017999 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 637910018000 metal binding site 2 [ion binding]; metal-binding site 637910018001 putative DNA binding helix; other site 637910018002 metal binding site 1 [ion binding]; metal-binding site 637910018003 dimer interface [polypeptide binding]; other site 637910018004 structural Zn2+ binding site [ion binding]; other site 637910018005 HMMPfam hit to PF01475, Ferric-uptake regulator, score 2.4e-06 637910018006 hypothetical protein; Provisional; Region: PRK10428 637910018007 HMMPfam hit to PF05532, CsbD-like, score 4.3e-25 637910018008 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 637910018009 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 637910018010 12 transmembrane helices predicted for ROD37021 by TMHMM2.0 at aa 11-33, 43-65, 89-111, 131-153, 160-182, 187-209, 241-263, 267-289, 321-343, 353-375, 388-405 and 409-428 637910018011 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 0.00058 637910018012 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 4.7e-40 637910018013 LexA repressor; Validated; Region: PRK00215 637910018014 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 637910018015 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 637910018016 Catalytic site [active] 637910018017 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, C-terminal, score 1.5e-22 637910018018 HMMPfam hit to PF01726, LexA DNA-binding region, score 4.7e-48 637910018019 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 637910018020 2 transmembrane helices predicted for ROD37041 by TMHMM2.0 at aa 57-79 and 99-121 637910018021 HMMPfam hit to PF01219, Prokaryotic diacylglycerol kinase, score 3.8e-61 637910018022 PS01069 Prokaryotic diacylglycerol kinase signature. 637910018023 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018024 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 637910018025 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 637910018026 putative acyl-acceptor binding pocket; other site 637910018027 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 1.3e-44 637910018028 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 637910018029 UbiA prenyltransferase family; Region: UbiA; pfam01040 637910018030 7 transmembrane helices predicted for ROD37061 by TMHMM2.0 at aa 23-40, 45-67, 99-132, 160-182, 213-232, 237-256 and 269-288 637910018031 HMMPfam hit to PF01040, UbiA prenyltransferase, score 2.4e-84 637910018032 PS00943 UbiA prenyltransferase family signature. 637910018033 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 637910018034 HMMPfam hit to PF04345, Chorismate lyase, score 9.5e-26 637910018035 PS00017 ATP/GTP-binding site motif A (P-loop). 637910018036 maltose regulon periplasmic protein; Provisional; Region: PRK10564 637910018037 HMMPfam hit to PF07148, Maltose operon periplasmic, score 1.3e-174 637910018038 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 637910018039 trimer interface; other site 637910018040 sugar binding site [chemical binding]; other site 637910018041 HMMPfam hit to PF02264, Porin, LamB type, score 1.6e-253 637910018042 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 637910018043 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 637910018044 Walker A/P-loop; other site 637910018045 ATP binding site [chemical binding]; other site 637910018046 Q-loop/lid; other site 637910018047 ABC transporter signature motif; other site 637910018048 Walker B; other site 637910018049 D-loop; other site 637910018050 H-loop/switch region; other site 637910018051 TOBE domain; Region: TOBE_2; pfam08402 637910018052 HMMPfam hit to PF08402, Transport-associated OB, type 2, score 1.9e-15 637910018053 HMMPfam hit to PF00005, ABC transporter related, score 7.1e-60 637910018054 PS00211 ABC transporters family signature. 637910018055 PS00017 ATP/GTP-binding site motif A (P-loop). 637910018056 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 637910018057 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 637910018058 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 4.2e-41 637910018059 PS01037 Bacterial extracellular solute-binding proteins, family 1 signature. 637910018060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910018061 dimer interface [polypeptide binding]; other site 637910018062 conserved gate region; other site 637910018063 putative PBP binding loops; other site 637910018064 ABC-ATPase subunit interface; other site 637910018065 8 transmembrane helices predicted for ROD37121 by TMHMM2.0 at aa 17-36, 40-57, 69-91, 284-306, 319-341, 370-392, 413-435 and 484-506 637910018066 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 5.7e-12 637910018067 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018068 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910018069 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637910018070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910018071 dimer interface [polypeptide binding]; other site 637910018072 conserved gate region; other site 637910018073 putative PBP binding loops; other site 637910018074 ABC-ATPase subunit interface; other site 637910018075 6 transmembrane helices predicted for ROD37131 by TMHMM2.0 at aa 13-35, 89-111, 124-143, 153-175, 205-227 and 258-280 637910018076 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.2e-14 637910018077 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910018078 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 637910018079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910018080 putative substrate translocation pore; other site 637910018081 HMMPfam hit to PF00083, General substrate transporter score 7.3e-179 637910018082 12 transmembrane helices predicted for ROD37141 by TMHMM2.0 at aa 13-35, 55-77, 90-109, 129-151, 164-186, 201-220, 271-293, 313-333, 346-368, 373-395, 408-427 and 442-464 637910018083 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018084 PS00217 Sugar transport proteins signature 2. 637910018085 PS00216 Sugar transport proteins signature 1. 637910018086 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018087 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637910018088 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910018089 DNA-binding site [nucleotide binding]; DNA binding site 637910018090 UTRA domain; Region: UTRA; pfam07702 637910018091 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 4.5e-43 637910018092 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 1.8e-17 637910018093 putative oxidoreductase; Provisional; Region: PRK10206 637910018094 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637910018095 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 637910018096 HMMPfam hit to PF02894, Oxidoreductase, C-terminal, score 7.3e-11 637910018097 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 2.5e-30 637910018098 PS00017 ATP/GTP-binding site motif A (P-loop). 637910018099 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 637910018100 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 637910018101 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 637910018102 active site 637910018103 P-loop; other site 637910018104 phosphorylation site [posttranslational modification] 637910018105 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 1.4e-14 637910018106 9 transmembrane helices predicted for ROD37181 by TMHMM2.0 at aa 29-51, 76-98, 103-122, 143-165, 191-213, 296-315, 341-360, 367-389 and 404-426 637910018107 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 8.7e-47 637910018108 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637910018109 methionine cluster; other site 637910018110 active site 637910018111 phosphorylation site [posttranslational modification] 637910018112 metal binding site [ion binding]; metal-binding site 637910018113 HMMPfam hit to PF02255, Phosphotransferase system, lactose/cellobiose-specific IIA subunit, score 3.2e-30 637910018114 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 637910018115 HMMPfam hit to PF06146, Phosphate-starvation-inducible E, score 6.3e-72 637910018116 4 transmembrane helices predicted for ROD37201 by TMHMM2.0 at aa 13-35, 55-77, 84-103 and 113-130 637910018117 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 637910018118 HMMPfam hit to PF06082, Protein of unknown function DUF940, bacterial membrane lipoprotein , score 0 637910018119 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018120 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 637910018121 HMMPfam hit to PF06251, Protein of unknown function DUF1017, score 1e-133 637910018122 1 transmembrane helix predicted for ROD37221 by TMHMM2.0 at aa 7-29 637910018123 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 637910018124 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018125 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 637910018126 1 transmembrane helix predicted for ROD37241 by TMHMM2.0 at aa 5-27 637910018127 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 637910018128 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 637910018129 active site 637910018130 dimer interface [polypeptide binding]; other site 637910018131 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 637910018132 dimer interface [polypeptide binding]; other site 637910018133 active site 637910018134 HMMPfam hit to PF00342, Phosphoglucose isomerase (PGI), score 0 637910018135 PS00174 Phosphoglucose isomerase signature 2. 637910018136 PS00765 Phosphoglucose isomerase signature 1. 637910018137 aspartate kinase III; Validated; Region: PRK09084 637910018138 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 637910018139 nucleotide binding site [chemical binding]; other site 637910018140 substrate binding site [chemical binding]; other site 637910018141 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 637910018142 lysine allosteric regulatory site; other site 637910018143 dimer interface [polypeptide binding]; other site 637910018144 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 637910018145 dimer interface [polypeptide binding]; other site 637910018146 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 1.1e-59 637910018147 PS00324 Aspartokinase signature. 637910018148 HMMPfam hit to PF01842, Amino acid-binding ACT, score 5.4e-06 637910018149 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 637910018150 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 637910018151 hypothetical protein; Reviewed; Region: PRK09588 637910018152 HMMPfam hit to PF01139, Protein of unknown function UPF0027, score 4.8e-178 637910018153 PS01288 Uncharacterized protein family UPF0027 signature. 637910018154 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 637910018155 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 637910018156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910018157 Walker A motif; other site 637910018158 ATP binding site [chemical binding]; other site 637910018159 Walker B motif; other site 637910018160 arginine finger; other site 637910018161 HMMPfam hit to PF06956, Regulator of RNA terminal phosphate cyclase, score 9.7e-93 637910018162 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 2.5e-56 637910018163 PS00017 ATP/GTP-binding site motif A (P-loop). 637910018164 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 637910018165 Sodium Bile acid symporter family; Region: SBF; cl17470 637910018166 9 transmembrane helices predicted for ROD37301 by TMHMM2.0 at aa 5-24, 29-51, 64-86, 92-114, 119-141, 156-178, 185-207, 217-239 and 260-282 637910018167 HMMPfam hit to PF01758, Bile acid:sodium symporter, score 4.6e-48 637910018168 hypothetical protein; Provisional; Region: PRK10515 637910018169 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 637910018170 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637910018171 RNA binding surface [nucleotide binding]; other site 637910018172 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 637910018173 probable active site [active] 637910018174 HMMPfam hit to PF00849, Pseudouridine synthase, score 3e-27 637910018175 PS01149 Rsu family of pseudouridine synthase signature. 637910018176 HMMPfam hit to PF01479, RNA-binding S4, score 1.2e-12 637910018177 Uncharacterized conserved protein [Function unknown]; Region: COG1683 637910018178 Uncharacterized conserved protein [Function unknown]; Region: COG3272 637910018179 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 637910018180 HMMPfam hit to PF08349, Protein of unknown function DUF1722, score 4e-64 637910018181 HMMPfam hit to PF04463, Protein of unknown function DUF523, score 2.9e-60 637910018182 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910018183 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018184 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 637910018185 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018186 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 637910018187 PS00213 Lipocalin signature. 637910018188 HMMPfam hit to PF08212, Lipocalin-like, score 3.2e-56 637910018189 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 637910018190 active site pocket [active] 637910018191 oxyanion hole [active] 637910018192 catalytic triad [active] 637910018193 active site nucleophile [active] 637910018194 HMMPfam hit to PF03575, Peptidase S51, dipeptidase E, score 2.2e-78 637910018195 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 637910018196 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 637910018197 7 transmembrane helices predicted for ROD37361 by TMHMM2.0 at aa 42-64, 74-96, 108-130, 150-172, 177-199, 214-236 and 249-271 637910018198 HMMPfam hit to PF02690, Na+/Pi-cotransporter score 8.9e-52 637910018199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637910018200 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637910018201 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637910018202 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 1.2e-17 637910018203 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.2e-27 637910018204 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 637910018205 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 637910018206 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 637910018207 substrate binding pocket [chemical binding]; other site 637910018208 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 637910018209 B12 binding site [chemical binding]; other site 637910018210 cobalt ligand [ion binding]; other site 637910018211 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 637910018212 HMMPfam hit to PF02965, vitamin B12 dependent methionine synthase, activation region, score 6.7e-80 637910018213 HMMPfam hit to PF02310, Cobalamin (vitamin B12)-binding, score 6.9e-29 637910018214 HMMPfam hit to PF02607, Methionine synthase, cobalamin (vitamin B12)-binding module, cap, score 4.5e-46 637910018215 HMMPfam hit to PF00809, Dihydropteroate synthase, DHPS, score 1.1e-79 637910018216 HMMPfam hit to PF02574, Homocysteine S-methyltransferase, score 5.5e-156 637910018217 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018218 transcriptional repressor IclR; Provisional; Region: PRK11569 637910018219 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 637910018220 Bacterial transcriptional regulator; Region: IclR; pfam01614 637910018221 HMMPfam hit to PF09339, Transcriptional regulator IclR, N-terminal, score 6.2e-34 637910018222 Predicted helix-turn-helix motif with score 1185.000, SD 3.22 at aa 44-65, sequence VALTELAQQAGLPNSTTHRLLT 637910018223 HMMPfam hit to PF01614, Transcriptional regulator IclR, C-terminal, score 2.1e-56 637910018224 PS01051 Bacterial regulatory proteins, iclR family signature. 637910018225 Predicted helix-turn-helix motif with score 1378.000, SD 3.88 at aa 173-194, sequence VSTRELARQTPVSQRTRRALLA 637910018226 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 637910018227 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 637910018228 HMMPfam hit to PF06315, Isocitrate dehydrogenase kinasephosphatase, score 0 637910018229 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910018230 isocitrate lyase; Provisional; Region: PRK15063 637910018231 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 637910018232 tetramer interface [polypeptide binding]; other site 637910018233 active site 637910018234 Mg2+/Mn2+ binding site [ion binding]; other site 637910018235 HMMPfam hit to PF00463, Isocitrate lyase and phosphorylmutase, score 3.7e-286 637910018236 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 637910018237 PS00161 Isocitrate lyase signature. 637910018238 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 637910018239 malate synthase A; Region: malate_syn_A; TIGR01344 637910018240 active site 637910018241 HMMPfam hit to PF01274, Malate synthase, score 0 637910018242 Predicted helix-turn-helix motif with score 1042.000, SD 2.74 at aa 442-463, sequence YGLMEDAATAEISRTSIWQWIH 637910018243 PS00510 Malate synthase signature. 637910018244 homoserine O-succinyltransferase; Provisional; Region: PRK05368 637910018245 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 637910018246 proposed active site lysine [active] 637910018247 conserved cys residue [active] 637910018248 HMMPfam hit to PF04204, Homoserine O-succinyltransferase, score 1.9e-205 637910018249 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 637910018250 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637910018251 Coenzyme A binding pocket [chemical binding]; other site 637910018252 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 7.6e-18 637910018253 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 637910018254 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 637910018255 purine monophosphate binding site [chemical binding]; other site 637910018256 dimer interface [polypeptide binding]; other site 637910018257 putative catalytic residues [active] 637910018258 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 637910018259 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 637910018260 HMMPfam hit to PF02142, MGS-like, score 2.3e-62 637910018261 HMMPfam hit to PF01808, AICARFT/IMPCHase bienzyme, formylation region, score 7.6e-225 637910018262 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 637910018263 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 637910018264 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 637910018265 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 637910018266 HMMPfam hit to PF02844, Phosphoribosylglycinamide synthetase, score 5e-63 637910018267 HMMPfam hit to PF01071, Phosphoribosylglycinamide synthetase, score 1.1e-137 637910018268 PS00184 Phosphoribosylglycinamide synthetase signature. 637910018269 HMMPfam hit to PF02843, Phosphoribosylglycinamide synthetase, score 9.2e-57 637910018270 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 637910018271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910018272 active site 637910018273 phosphorylation site [posttranslational modification] 637910018274 intermolecular recognition site; other site 637910018275 dimerization interface [polypeptide binding]; other site 637910018276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910018277 Walker A motif; other site 637910018278 ATP binding site [chemical binding]; other site 637910018279 Walker B motif; other site 637910018280 arginine finger; other site 637910018281 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 637910018282 Predicted helix-turn-helix motif with score 1472.000, SD 4.20 at aa 419-440, sequence GNKTEAARQLGITRKTLLAKLS 637910018283 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 1.2e-15 637910018284 PS00688 Sigma-54 interaction domain C-terminal part signature. 637910018285 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 1e-158 637910018286 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 637910018287 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 637910018288 HMMPfam hit to PF00072, Response regulator receiver, score 8.1e-48 637910018289 sensor protein ZraS; Provisional; Region: PRK10364 637910018290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637910018291 dimer interface [polypeptide binding]; other site 637910018292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910018293 ATP binding site [chemical binding]; other site 637910018294 Mg2+ binding site [ion binding]; other site 637910018295 G-X-G motif; other site 637910018296 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2e-39 637910018297 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 7.2e-15 637910018298 2 transmembrane helices predicted for ROD37491 by TMHMM2.0 at aa 15-32 and 201-223 637910018299 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 637910018300 dimer interface [polypeptide binding]; other site 637910018301 1 transmembrane helix predicted for ROD37501 by TMHMM2.0 at aa 9-31 637910018302 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 637910018303 HMMPfam hit to PF07356, Protein of unknown function DUF1481, score 4.9e-171 637910018304 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018305 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 637910018306 IHF dimer interface [polypeptide binding]; other site 637910018307 IHF - DNA interface [nucleotide binding]; other site 637910018308 HMMPfam hit to PF00216, Histone-like bacterial DNA-binding protein, score 7e-51 637910018309 PS00045 Bacterial histone-like DNA-binding proteins signature. 637910018310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 637910018311 HMMPfam hit to PF04222, Protein of unknown function DUF416, score 5.2e-161 637910018312 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 637910018313 Active_site [active] 637910018314 HMMPfam hit to PF04493, Endonuclease V, score 6.3e-110 637910018315 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 637910018316 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 637910018317 substrate binding site [chemical binding]; other site 637910018318 active site 637910018319 HMMPfam hit to PF01208, Uroporphyrinogen decarboxylase (URO-D), score 9e-215 637910018320 PS00907 Uroporphyrinogen decarboxylase signature 2. 637910018321 PS00906 Uroporphyrinogen decarboxylase signature 1. 637910018322 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 637910018323 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 637910018324 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 637910018325 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 637910018326 putative NADH binding site [chemical binding]; other site 637910018327 putative active site [active] 637910018328 nudix motif; other site 637910018329 putative metal binding site [ion binding]; other site 637910018330 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 9.9e-30 637910018331 PS00893 mutT domain signature. 637910018332 HMMPfam hit to PF09297, Zinc ribbon, NADH pyrophosphatase, score 1.5e-14 637910018333 HMMPfam hit to PF09296, NADH pyrophosphatase-like, N-terminal, score 1.1e-10 637910018334 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 637910018335 HMMPfam hit to PF04353, Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ, score 1.6e-102 637910018336 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 637910018337 ThiC-associated domain; Region: ThiC-associated; pfam13667 637910018338 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 637910018339 HMMPfam hit to PF01964, Thiamine biosynthesis protein ThiC, score 0 637910018340 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018341 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 637910018342 thiamine phosphate binding site [chemical binding]; other site 637910018343 active site 637910018344 pyrophosphate binding site [ion binding]; other site 637910018345 HMMPfam hit to PF02581, Thiamine monophosphate synthase, score 4.3e-84 637910018346 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 637910018347 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 637910018348 ATP binding site [chemical binding]; other site 637910018349 substrate interface [chemical binding]; other site 637910018350 HMMPfam hit to PF00899, UBA/THIF-type NAD/FAD binding fold, score 2.9e-63 637910018351 HMMPfam hit to PF05237, MoeZ/MoeB, score 3.3e-41 637910018352 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 637910018353 thiS-thiF/thiG interaction site; other site 637910018354 HMMPfam hit to PF02597, ThiamineS, score 4.9e-17 637910018355 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 637910018356 ThiS interaction site; other site 637910018357 putative active site [active] 637910018358 tetramer interface [polypeptide binding]; other site 637910018359 HMMPfam hit to PF05690, Thiazole biosynthesis, score 4e-171 637910018360 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 637910018361 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910018362 FeS/SAM binding site; other site 637910018363 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 637910018364 HMMPfam hit to PF04055, Radical SAM, score 3.5e-09 637910018365 HMMPfam hit to PF06968, Biotin and thiamin synthesis associated, score 1.9e-39 637910018366 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 637910018367 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 637910018368 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 637910018369 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 637910018370 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 637910018371 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 637910018372 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 637910018373 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 637910018374 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 637910018375 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 637910018376 DNA binding site [nucleotide binding] 637910018377 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 637910018378 HMMPfam hit to PF04998, RNA polymerase Rpb1, domain 5, score 1.3e-110 637910018379 HMMPfam hit to PF05000, RNA polymerase Rpb1, domain 4, score 7.2e-30 637910018380 HMMPfam hit to PF04983, RNA polymerase Rpb1, domain 3, score 6.4e-54 637910018381 HMMPfam hit to PF00623, RNA polymerase, subunit alpha, score 2e-83 637910018382 HMMPfam hit to PF04997, RNA polymerase Rpb1, domain 1, score 1.6e-168 637910018383 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 637910018384 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 637910018385 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 637910018386 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 637910018387 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 637910018388 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 637910018389 RPB3 interaction site [polypeptide binding]; other site 637910018390 RPB1 interaction site [polypeptide binding]; other site 637910018391 RPB11 interaction site [polypeptide binding]; other site 637910018392 RPB10 interaction site [polypeptide binding]; other site 637910018393 HMMPfam hit to PF04560, RNA polymerase Rpb2, domain 7, score 4.2e-52 637910018394 HMMPfam hit to PF00562, RNA polymerase Rpb2, domain 6, score 7.4e-187 637910018395 PS01166 RNA polymerases subunit beta signature. 637910018396 HMMPfam hit to PF04565, RNA polymerase Rpb2, domain 3, score 1.8e-43 637910018397 HMMPfam hit to PF04563, RNA polymerase, beta subunit, protrusion, score 6.4e-36 637910018398 HMMPfam hit to PF04561, RNA polymerase Rpb2, domain 2, score 2.9e-06 637910018399 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 637910018400 core dimer interface [polypeptide binding]; other site 637910018401 peripheral dimer interface [polypeptide binding]; other site 637910018402 L10 interface [polypeptide binding]; other site 637910018403 L11 interface [polypeptide binding]; other site 637910018404 putative EF-Tu interaction site [polypeptide binding]; other site 637910018405 putative EF-G interaction site [polypeptide binding]; other site 637910018406 HMMPfam hit to PF00542, Ribosomal protein L7/L12, C-terminal, score 1.6e-37 637910018407 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 637910018408 23S rRNA interface [nucleotide binding]; other site 637910018409 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 637910018410 HMMPfam hit to PF00466, Ribosomal protein L10, score 1.5e-36 637910018411 PS01109 Ribosomal protein L10 signature. 637910018412 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 637910018413 mRNA/rRNA interface [nucleotide binding]; other site 637910018414 HMMPfam hit to PF00687, Ribosomal protein L1, score 6.8e-137 637910018415 PS01199 Ribosomal protein L1 signature. 637910018416 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 637910018417 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 637910018418 23S rRNA interface [nucleotide binding]; other site 637910018419 L7/L12 interface [polypeptide binding]; other site 637910018420 putative thiostrepton binding site; other site 637910018421 L25 interface [polypeptide binding]; other site 637910018422 PS00359 Ribosomal protein L11 signature. 637910018423 HMMPfam hit to PF00298, Ribosomal protein L11, score 6.8e-39 637910018424 HMMPfam hit to PF03946, Ribosomal protein L11, score 2.1e-38 637910018425 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 637910018426 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 637910018427 putative homodimer interface [polypeptide binding]; other site 637910018428 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 637910018429 heterodimer interface [polypeptide binding]; other site 637910018430 homodimer interface [polypeptide binding]; other site 637910018431 PS01014 Transcription termination factor nusG signature. 637910018432 HMMPfam hit to PF00467, KOW, score 1.6e-11 637910018433 HMMPfam hit to PF02357, Transcription antitermination protein, NusG, N-terminal, score 1.6e-56 637910018434 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 637910018435 HMMPfam hit to PF00584, Protein secE/sec61-gamma protein, score 3.2e-26 637910018436 3 transmembrane helices predicted for ROD37711 by TMHMM2.0 at aa 13-35, 40-62 and 94-116 637910018437 PS01067 Protein secE/sec61-gamma signature. 637910018438 elongation factor Tu; Reviewed; Region: PRK00049 637910018439 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 637910018440 G1 box; other site 637910018441 GEF interaction site [polypeptide binding]; other site 637910018442 GTP/Mg2+ binding site [chemical binding]; other site 637910018443 Switch I region; other site 637910018444 G2 box; other site 637910018445 G3 box; other site 637910018446 Switch II region; other site 637910018447 G4 box; other site 637910018448 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 637910018449 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 637910018450 Antibiotic Binding Site [chemical binding]; other site 637910018451 HMMPfam hit to PF03143, Translation elongation factor EFTu/EF1A, C-terminal, score 1e-60 637910018452 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 1.3e-25 637910018453 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 4.1e-96 637910018454 PS00301 GTP-binding elongation factors signature. 637910018455 PS00017 ATP/GTP-binding site motif A (P-loop). 637910018456 pantothenate kinase; Provisional; Region: PRK05439 637910018457 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 637910018458 ATP-binding site [chemical binding]; other site 637910018459 CoA-binding site [chemical binding]; other site 637910018460 Mg2+-binding site [ion binding]; other site 637910018461 HMMPfam hit to PF00485, Phosphoribulokinase/uridine kinase, score 4.7e-07 637910018462 PS00017 ATP/GTP-binding site motif A (P-loop). 637910018463 Biotin operon repressor [Transcription]; Region: BirA; COG1654 637910018464 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 637910018465 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 637910018466 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 637910018467 HMMPfam hit to PF02237, Biotin protein ligase, C-terminal, score 2.7e-10 637910018468 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase, score 1.2e-26 637910018469 HMMPfam hit to PF08279, Helix-turn-helix, type 11, score 4.6e-11 637910018470 Predicted helix-turn-helix motif with score 1652.000, SD 4.81 at aa 20-41, sequence HSGEQLGETLGMSRAAINKHIQ 637910018471 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 637910018472 FAD binding domain; Region: FAD_binding_4; pfam01565 637910018473 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 637910018474 HMMPfam hit to PF02873, UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal, score 7e-72 637910018475 HMMPfam hit to PF01565, FAD linked oxidase, N-terminal, score 1.2e-26 637910018476 glutamate racemase; Provisional; Region: PRK00865 637910018477 HMMPfam hit to PF01177, Asp/Glu/hydantoin racemase, score 1.3e-89 637910018478 PS00924 Aspartate and glutamate racemases signature 2. 637910018479 PS00923 Aspartate and glutamate racemases signature 1. 637910018480 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 637910018481 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 637910018482 N-terminal plug; other site 637910018483 ligand-binding site [chemical binding]; other site 637910018484 HMMPfam hit to PF00593, TonB-dependent receptor, beta-barrel, score 7e-25 637910018485 PS01156 TonB-dependent receptor proteins signature 2. 637910018486 HMMPfam hit to PF07715, TonB-dependent receptor, plug, score 2.2e-25 637910018487 PS00430 TonB-dependent receptor proteins signature 1. 637910018488 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 637910018489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910018490 S-adenosylmethionine binding site [chemical binding]; other site 637910018491 HMMPfam hit to PF05958, (Uracil-5)-methyltransferase, score 3.9e-277 637910018492 PS01230 RNA methyltransferase trmA family signature 1. 637910018493 PS01231 RNA methyltransferase trmA family signature 2. 637910018494 hypothetical protein; Provisional; Region: PRK11056 637910018495 HMMPfam hit to PF07226, Protein of unknown function DUF1422, score 3e-79 637910018496 3 transmembrane helices predicted for ROD37811 by TMHMM2.0 at aa 25-47, 60-82 and 86-108 637910018497 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018498 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 637910018499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637910018500 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 7.7e-13 637910018501 Predicted helix-turn-helix motif with score 1809.000, SD 5.35 at aa 32-53, sequence LSLREVAREAGIAPTSFYRHFR 637910018502 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 637910018503 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637910018504 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637910018505 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 5.8e-43 637910018506 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 1.4e-27 637910018507 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018508 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 1.6e-38 637910018509 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 637910018510 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910018511 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 637910018512 dimerization interface [polypeptide binding]; other site 637910018513 HMMPfam hit to PF03466, LysR, substrate-binding, score 3.4e-58 637910018514 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.4e-21 637910018515 PS00044 Bacterial regulatory proteins, lysR family signature. 637910018516 Predicted helix-turn-helix motif with score 1674.000, SD 4.89 at aa 16-37, sequence RHFRRAADSCHVSQPTLSGQIR 637910018517 argininosuccinate lyase; Provisional; Region: PRK04833 637910018518 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 637910018519 active sites [active] 637910018520 tetramer interface [polypeptide binding]; other site 637910018521 HMMPfam hit to PF00206, Fumarate lyase, score 1.7e-145 637910018522 PS00163 Fumarate lyases signature. 637910018523 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 637910018524 nucleotide binding site [chemical binding]; other site 637910018525 N-acetyl-L-glutamate binding site [chemical binding]; other site 637910018526 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 1.5e-41 637910018527 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 637910018528 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 637910018529 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisation region, score 1.1e-36 637910018530 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD - binding, score 5e-59 637910018531 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 637910018532 acetylornithine deacetylase; Provisional; Region: PRK05111 637910018533 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 637910018534 metal binding site [ion binding]; metal-binding site 637910018535 putative dimer interface [polypeptide binding]; other site 637910018536 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 637910018537 HMMPfam hit to PF01546, Peptidase M20, score 2.2e-41 637910018538 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 637910018539 HMMPfam hit to PF07687, Peptidase M20, dimerisation, score 7e-32 637910018540 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 637910018541 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 637910018542 HMMPfam hit to PF00311, Phosphoenolpyruvate carboxylase, score 3.1e-227 637910018543 Predicted helix-turn-helix motif with score 1127.000, SD 3.03 at aa 106-127, sequence RTLRKLKNQPNLNEATIKKAVE 637910018544 PS00781 Phosphoenolpyruvate carboxylase active site 1. 637910018545 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018546 PS00393 Phosphoenolpyruvate carboxylase active site 2. 637910018547 hypothetical protein; Provisional; Region: PRK10649 637910018548 Sulfatase; Region: Sulfatase; pfam00884 637910018549 4 transmembrane helices predicted for ROD37901 by TMHMM2.0 at aa 20-42, 69-91, 117-139 and 152-174 637910018550 HMMPfam hit to PF00884, Sulphatase, score 5.4e-70 637910018551 pseudogene, truncated by premature stop codon 637910018552 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.9e-05 637910018553 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 8.2e-14 637910018554 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 637910018555 active site 637910018556 P-loop; other site 637910018557 phosphorylation site [posttranslational modification] 637910018558 HMMPfam hit to PF02379, Phosphotransferase system, fructose-specific IIB subunit, score 8.7e-54 637910018559 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910018560 FeS/SAM binding site; other site 637910018561 pyruvate formate lyase II activase; Provisional; Region: PRK10076 637910018562 HMMPfam hit to PF04055, Radical SAM, score 1.6e-17 637910018563 PS01087 Radical activating enzymes signature. 637910018564 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 637910018565 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 637910018566 dimer interface [polypeptide binding]; other site 637910018567 active site 637910018568 glycine loop; other site 637910018569 HMMPfam hit to PF01228, Formate C-acetyltransferase glycine radical, score 7e-45 637910018570 PS00850 Glycine radical signature. 637910018571 HMMPfam hit to PF02901, Pyruvate formate-lyase, PFL, score 1.3e-303 637910018572 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 637910018573 active site 637910018574 P-loop; other site 637910018575 phosphorylation site [posttranslational modification] 637910018576 HMMPfam hit to PF02379, Phosphotransferase system, fructose-specific IIB subunit, score 1.2e-62 637910018577 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 637910018578 8 transmembrane helices predicted for ROD37961 by TMHMM2.0 at aa 21-40, 60-82, 95-117, 132-154, 175-194, 214-236, 283-305 and 315-334 637910018579 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018580 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.6e-05 637910018581 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 637910018582 dimerization domain swap beta strand [polypeptide binding]; other site 637910018583 regulatory protein interface [polypeptide binding]; other site 637910018584 active site 637910018585 regulatory phosphorylation site [posttranslational modification]; other site 637910018586 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 637910018587 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 637910018588 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 637910018589 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 637910018590 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637910018591 active site 637910018592 phosphorylation site [posttranslational modification] 637910018593 HMMPfam hit to PF00381, Phosphotransferase system, phosphocarrier HPr protein, score 5.1e-07 637910018594 PS00369 PTS HPR component histidine phosphorylation site signature. 637910018595 HMMPfam hit to PF05524, Phosphotransferase system, PEP-utilising enzyme, N-terminal, score 0.0012 637910018596 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile region, score 4.9e-24 637910018597 PS00370 PEP-utilizing enzymes phosphorylation site signature. 637910018598 HMMPfam hit to PF02896, PEP-utilizing enzyme, score 2.5e-164 637910018599 PS00742 PEP-utilizing enzymes signature 2. 637910018600 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 2.8e-12 637910018601 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 637910018602 active site 637910018603 intersubunit interactions; other site 637910018604 catalytic residue [active] 637910018605 HMMPfam hit to PF00923, Transaldolase, score 2.7e-95 637910018606 PS01054 Transaldolase signature 1. 637910018607 PS00958 Transaldolase active site. 637910018608 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 637910018609 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 637910018610 dimer interface [polypeptide binding]; other site 637910018611 active site 637910018612 metal binding site [ion binding]; metal-binding site 637910018613 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 1.9e-84 637910018614 PS00913 Iron-containing alcohol dehydrogenases signature 1. 637910018615 PS00060 Iron-containing alcohol dehydrogenases signature 2. 637910018616 PS00687 Aldehyde dehydrogenases glutamic acid active site. 637910018617 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 637910018618 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 637910018619 heme binding site [chemical binding]; other site 637910018620 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 637910018621 HMMPfam hit to PF00141, Haem peroxidase, plant/fungal/bacterial, score 9.8e-106 637910018622 HMMPfam hit to PF00141, Haem peroxidase, plant/fungal/bacterial, score 2.8e-85 637910018623 PS00017 ATP/GTP-binding site motif A (P-loop). 637910018624 PS00435 Peroxidases proximal heme-ligand signature. 637910018625 PS00436 Peroxidases active site signature. 637910018626 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 637910018627 FAD binding site [chemical binding]; other site 637910018628 HMMPfam hit to PF02219, Methylenetetrahydrofolate reductase, score 1.9e-159 637910018629 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637910018630 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637910018631 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637910018632 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 0.00017 637910018633 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 2.7e-31 637910018634 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 637910018635 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 637910018636 putative catalytic residues [active] 637910018637 putative nucleotide binding site [chemical binding]; other site 637910018638 putative aspartate binding site [chemical binding]; other site 637910018639 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 637910018640 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 637910018641 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 637910018642 HMMPfam hit to PF00742, Homoserine dehydrogenase, catalytic, score 1.2e-105 637910018643 PS01042 Homoserine dehydrogenase signature. 637910018644 HMMPfam hit to PF03447, Aspartate/homoserine dehydrogenase, NAD-binding, score 4.9e-44 637910018645 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 2e-47 637910018646 Predicted helix-turn-helix motif with score 1063.000, SD 2.81 at aa 212-233, sequence YSATQIGALAGVSRVTIWSDVA 637910018647 PS00324 Aspartokinase signature. 637910018648 cystathionine gamma-synthase; Provisional; Region: PRK08045 637910018649 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 637910018650 homodimer interface [polypeptide binding]; other site 637910018651 substrate-cofactor binding pocket; other site 637910018652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910018653 catalytic residue [active] 637910018654 HMMPfam hit to PF01053, Cys/Met metabolism, pyridoxal phosphate-dependent enzyme, score 6.1e-221 637910018655 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 637910018656 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 637910018657 dimerization interface [polypeptide binding]; other site 637910018658 DNA binding site [nucleotide binding] 637910018659 corepressor binding sites; other site 637910018660 HMMPfam hit to PF01340, Methionine repressor MetJ, score 4.4e-87 637910018661 3 transmembrane helices predicted for ROD38071 by TMHMM2.0 at aa 7-29, 39-56 and 110-132 637910018662 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 637910018663 HMMPfam hit to PF07377, Protein of unknown function DUF1493, score 2e-24 637910018664 Protein of unknown function (DUF796); Region: DUF796; cl01226 637910018665 HMMPfam hit to PF05638, Virulence factor for secretion apparatus, score 7.8e-39 637910018666 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 637910018667 HMMPfam hit to PF01197, Ribosomal protein L31, score 3.7e-44 637910018668 PS01143 Ribosomal protein L31 signature. 637910018669 PS00190 Cytochrome c family heme-binding site signature. 637910018670 primosome assembly protein PriA; Validated; Region: PRK05580 637910018671 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637910018672 ATP binding site [chemical binding]; other site 637910018673 putative Mg++ binding site [ion binding]; other site 637910018674 helicase superfamily c-terminal domain; Region: HELICc; smart00490 637910018675 ATP-binding site [chemical binding]; other site 637910018676 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 4.1e-33 637910018677 PS00017 ATP/GTP-binding site motif A (P-loop). 637910018678 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 5.8e-08 637910018679 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910018680 DNA binding site [nucleotide binding] 637910018681 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 637910018682 domain linker motif; other site 637910018683 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 637910018684 dimerization interface [polypeptide binding]; other site 637910018685 ligand binding site [chemical binding]; other site 637910018686 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 1.1e-12 637910018687 Predicted helix-turn-helix motif with score 1699.000, SD 4.97 at aa 10-31, sequence ATMKDVAEKAKVSTATVSRALM 637910018688 PS00356 Bacterial regulatory proteins, lacI family signature. 637910018689 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 6.2e-27 637910018690 essential cell division protein FtsN; Provisional; Region: PRK10927 637910018691 cell division protein FtsN; Provisional; Region: PRK12757 637910018692 1 transmembrane helix predicted for ROD38131 by TMHMM2.0 at aa 32-54 637910018693 HMMPfam hit to PF05036, Sporulation/cell division region, bacteria, score 1.9e-19 637910018694 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 637910018695 active site 637910018696 HslU subunit interaction site [polypeptide binding]; other site 637910018697 HMMPfam hit to PF00227, 20S proteasome, A and B subunits, score 4.6e-36 637910018698 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 637910018699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910018700 Walker A motif; other site 637910018701 ATP binding site [chemical binding]; other site 637910018702 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 637910018703 Walker B motif; other site 637910018704 arginine finger; other site 637910018705 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 637910018706 HMMPfam hit to PF07724, ATPase AAA-2, score 8.3e-14 637910018707 PS00017 ATP/GTP-binding site motif A (P-loop). 637910018708 HMMPfam hit to PF07724, ATPase AAA-2, score 5.3e-57 637910018709 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 637910018710 UbiA prenyltransferase family; Region: UbiA; pfam01040 637910018711 9 transmembrane helices predicted for ROD38161 by TMHMM2.0 at aa 21-38, 42-64, 99-121, 125-144, 151-173, 178-200, 230-249, 253-270 and 291-308 637910018712 HMMPfam hit to PF01040, UbiA prenyltransferase, score 1.1e-46 637910018713 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018714 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 637910018715 HMMPfam hit to PF03737, Ribonuclease E inhibitor RraA/Dimethylmenaquinone methyltransferase, score 2.5e-77 637910018716 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910018717 1 transmembrane helix predicted for ROD38181 by TMHMM2.0 at aa 309-331 637910018718 HMMPfam hit to PF01609, Transposase, IS4-like, score 5.4e-13 637910018719 septal ring assembly protein ZapB; Provisional; Region: PRK15422 637910018720 HMMPfam hit to PF06005, Protein of unknown function DUF904, score 1.9e-42 637910018721 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 637910018722 amphipathic channel; other site 637910018723 Asn-Pro-Ala signature motifs; other site 637910018724 HMMPfam hit to PF00230, major intrinsic protein, score 1.9e-119 637910018725 6 transmembrane helices predicted for ROD38211 by TMHMM2.0 at aa 12-34, 44-66, 87-109, 143-165, 178-200 and 230-249 637910018726 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018727 PS00221 MIP family signature. 637910018728 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018729 glycerol kinase; Provisional; Region: glpK; PRK00047 637910018730 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 637910018731 N- and C-terminal domain interface [polypeptide binding]; other site 637910018732 active site 637910018733 MgATP binding site [chemical binding]; other site 637910018734 catalytic site [active] 637910018735 metal binding site [ion binding]; metal-binding site 637910018736 glycerol binding site [chemical binding]; other site 637910018737 homotetramer interface [polypeptide binding]; other site 637910018738 homodimer interface [polypeptide binding]; other site 637910018739 FBP binding site [chemical binding]; other site 637910018740 protein IIAGlc interface [polypeptide binding]; other site 637910018741 HMMPfam hit to PF00370, Carbohydrate kinase, FGGY, score 2.6e-134 637910018742 PS00933 FGGY family of carbohydrate kinases signature 1. 637910018743 HMMPfam hit to PF02782, Carbohydrate kinase, FGGY, score 1.5e-111 637910018744 PS00445 FGGY family of carbohydrate kinases signature 2. 637910018745 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 637910018746 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 637910018747 putative active site [active] 637910018748 HMMPfam hit to PF03320, GlpX, score 6.4e-244 637910018749 ferredoxin-NADP reductase; Provisional; Region: PRK10926 637910018750 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 637910018751 FAD binding pocket [chemical binding]; other site 637910018752 FAD binding motif [chemical binding]; other site 637910018753 phosphate binding motif [ion binding]; other site 637910018754 beta-alpha-beta structure motif; other site 637910018755 NAD binding pocket [chemical binding]; other site 637910018756 PS00430 TonB-dependent receptor proteins signature 1. 637910018757 HMMPfam hit to PF00970, Oxidoreductase FAD-binding region, score 8.3e-05 637910018758 HMMPfam hit to PF00175, Oxidoreductase FAD/NAD(P)-binding, score 6.1e-22 637910018759 2 transmembrane helices predicted for ROD38251 by TMHMM2.0 at aa 24-46 and 59-76 637910018760 Predicted membrane protein [Function unknown]; Region: COG3152 637910018761 HMMPfam hit to PF05656, Protein of unknown function DUF805, score 3.3e-52 637910018762 4 transmembrane helices predicted for ROD38261 by TMHMM2.0 at aa 20-37, 41-63, 72-94 and 99-121 637910018763 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 637910018764 HMMPfam hit to PF07305, Protein of unknown function DUF1454, score 7.8e-135 637910018765 1 transmembrane helix predicted for ROD38271 by TMHMM2.0 at aa 7-29 637910018766 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018767 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 637910018768 triosephosphate isomerase; Provisional; Region: PRK14567 637910018769 substrate binding site [chemical binding]; other site 637910018770 dimer interface [polypeptide binding]; other site 637910018771 catalytic triad [active] 637910018772 HMMPfam hit to PF00121, Triosephosphate isomerase, score 4.7e-133 637910018773 PS00171 Triosephosphate isomerase active site. 637910018774 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 637910018775 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 637910018776 transmembrane helices; other site 637910018777 10 transmembrane helices predicted for ROD38291 by TMHMM2.0 at aa 10-32, 52-74, 94-113, 142-164, 195-214, 235-254, 258-275, 288-307, 327-349 and 406-428 637910018778 HMMPfam hit to PF03600, Divalent ion symporter, score 8.4e-05 637910018779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 637910018780 HMMPfam hit to PF07661, MORN variant, score 0.15 637910018781 HMMPfam hit to PF07661, MORN variant, score 1.5 637910018782 HMMPfam hit to PF07661, MORN variant, score 4 637910018783 HMMPfam hit to PF07661, MORN variant, score 37 637910018784 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018785 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 637910018786 HMMPfam hit to PF02611, CDP-diacylglycerol pyrophosphatase, bacterial, score 3.3e-154 637910018787 1 transmembrane helix predicted for ROD38321 by TMHMM2.0 at aa 5-23 637910018788 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 637910018789 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637910018790 substrate binding pocket [chemical binding]; other site 637910018791 membrane-bound complex binding site; other site 637910018792 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 8.4e-17 637910018793 PS00757 Prokaryotic sulfate-binding proteins signature 2. 637910018794 PS00401 Prokaryotic sulfate-binding proteins signature 1. 637910018795 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 637910018796 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 637910018797 active site 637910018798 ADP/pyrophosphate binding site [chemical binding]; other site 637910018799 dimerization interface [polypeptide binding]; other site 637910018800 allosteric effector site; other site 637910018801 fructose-1,6-bisphosphate binding site; other site 637910018802 HMMPfam hit to PF00365, Phosphofructokinase, score 2.8e-191 637910018803 PS00433 Phosphofructokinase signature. 637910018804 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018805 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 637910018806 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 637910018807 HMMPfam hit to PF01545, Cation efflux protein, score 1.5e-109 637910018808 6 transmembrane helices predicted for ROD38351 by TMHMM2.0 at aa 12-34, 38-60, 80-102, 117-139, 158-175 and 180-199 637910018809 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 637910018810 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018811 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 637910018812 dimer interface [polypeptide binding]; other site 637910018813 HMMPfam hit to PF07813, Region of unknown function, Spy-related, score 0.00013 637910018814 HMMPfam hit to PF07813, Region of unknown function, Spy-related, score 0.0012 637910018815 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 637910018816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910018817 active site 637910018818 intermolecular recognition site; other site 637910018819 dimerization interface [polypeptide binding]; other site 637910018820 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637910018821 DNA binding site [nucleotide binding] 637910018822 HMMPfam hit to PF00072, Response regulator receiver, score 2.7e-42 637910018823 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1.7e-22 637910018824 two-component sensor protein; Provisional; Region: cpxA; PRK09470 637910018825 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637910018826 dimerization interface [polypeptide binding]; other site 637910018827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637910018828 dimer interface [polypeptide binding]; other site 637910018829 phosphorylation site [posttranslational modification] 637910018830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910018831 ATP binding site [chemical binding]; other site 637910018832 Mg2+ binding site [ion binding]; other site 637910018833 G-X-G motif; other site 637910018834 2 transmembrane helices predicted for ROD38391 by TMHMM2.0 at aa 5-27 and 165-187 637910018835 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 9.8e-14 637910018836 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 3.7e-17 637910018837 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.1e-38 637910018838 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 637910018839 MOSC domain; Region: MOSC; pfam03473 637910018840 3-alpha domain; Region: 3-alpha; pfam03475 637910018841 HMMPfam hit to PF03475, Protein of unknown function 3-alpha region, score 2.8e-17 637910018842 HMMPfam hit to PF03473, Molybdenum cofactor sulphurase, C-terminal, score 2.2e-48 637910018843 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 637910018844 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 637910018845 inhibitor site; inhibition site 637910018846 active site 637910018847 dimer interface [polypeptide binding]; other site 637910018848 catalytic residue [active] 637910018849 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase, score 4.3e-34 637910018850 superoxide dismutase; Provisional; Region: PRK10925 637910018851 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 637910018852 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 637910018853 HMMPfam hit to PF02777, Manganese and iron superoxide dismutase, score 2.9e-70 637910018854 PS00088 Manganese and iron superoxide dismutases signature. 637910018855 HMMPfam hit to PF00081, Manganese and iron superoxide dismutase, score 8.5e-55 637910018856 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 637910018857 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 637910018858 HMMPfam hit to PF06379, RhaT l-rhamnose-proton symport 2, score 1.9e-290 637910018859 10 transmembrane helices predicted for ROD38441 by TMHMM2.0 at aa 4-26, 38-55, 70-92, 99-121, 136-155, 175-192, 212-234, 254-276, 291-310 and 321-343 637910018860 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018861 transcriptional activator RhaR; Provisional; Region: PRK13502 637910018862 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 637910018863 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910018864 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 1.4e-13 637910018865 PS00041 Bacterial regulatory proteins, araC family signature. 637910018866 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 0.00086 637910018867 HMMPfam hit to PF02311, AraC protein, arabinose-binding/dimerisation, score 2.5e-20 637910018868 transcriptional activator RhaS; Provisional; Region: PRK13503 637910018869 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 637910018870 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910018871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910018872 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 1.9e-14 637910018873 PS00041 Bacterial regulatory proteins, araC family signature. 637910018874 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 4.8e-07 637910018875 Predicted helix-turn-helix motif with score 1562.000, SD 4.51 at aa 188-209, sequence ICWEALAERFSLSLRTLHRQLK 637910018876 HMMPfam hit to PF02311, AraC protein, arabinose-binding/dimerisation, score 3.5e-26 637910018877 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 637910018878 N- and C-terminal domain interface [polypeptide binding]; other site 637910018879 active site 637910018880 putative catalytic site [active] 637910018881 metal binding site [ion binding]; metal-binding site 637910018882 ATP binding site [chemical binding]; other site 637910018883 rhamnulokinase; Provisional; Region: rhaB; PRK10640 637910018884 carbohydrate binding site [chemical binding]; other site 637910018885 HMMPfam hit to PF00370, Carbohydrate kinase, FGGY, score 9.3e-22 637910018886 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018887 L-rhamnose isomerase; Provisional; Region: PRK01076 637910018888 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 637910018889 HMMPfam hit to PF06134, Rhamnose isomerase, score 0 637910018890 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 637910018891 intersubunit interface [polypeptide binding]; other site 637910018892 active site 637910018893 Zn2+ binding site [ion binding]; other site 637910018894 HMMPfam hit to PF00596, Class II aldolase/adducin, N-terminal, score 4.6e-29 637910018895 lactaldehyde reductase; Region: lactal_redase; TIGR02638 637910018896 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 637910018897 dimer interface [polypeptide binding]; other site 637910018898 active site 637910018899 metal binding site [ion binding]; metal-binding site 637910018900 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 5.8e-153 637910018901 PS00913 Iron-containing alcohol dehydrogenases signature 1. 637910018902 PS00060 Iron-containing alcohol dehydrogenases signature 2. 637910018903 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 637910018904 HMMPfam hit to PF05336, Rhamnose mutarotase, score 9.2e-58 637910018905 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 637910018906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637910018907 non-specific DNA binding site [nucleotide binding]; other site 637910018908 salt bridge; other site 637910018909 sequence-specific DNA binding site [nucleotide binding]; other site 637910018910 Cupin domain; Region: Cupin_2; cl17218 637910018911 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018912 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 4.5e-13 637910018913 Predicted helix-turn-helix motif with score 2052.000, SD 6.18 at aa 21-42, sequence LSLAEIARRAGIAKSTLSQLEA 637910018914 AzlC protein; Region: AzlC; cl00570 637910018915 HMMPfam hit to PF03591, AzlC-like, score 5e-43 637910018916 5 transmembrane helices predicted for ROD38541 by TMHMM2.0 at aa 21-43, 58-80, 127-149, 159-178 and 191-213 637910018917 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 637910018918 4 transmembrane helices predicted for ROD38551 by TMHMM2.0 at aa 4-26, 38-60, 65-82 and 87-106 637910018919 HMMPfam hit to PF05437, Branched-chain amino acid transport, score 1.7e-17 637910018920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910018921 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 637910018922 Walker A motif; other site 637910018923 ATP binding site [chemical binding]; other site 637910018924 Walker B motif; other site 637910018925 arginine finger; other site 637910018926 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 637910018927 active pocket/dimerization site; other site 637910018928 active site 637910018929 phosphorylation site [posttranslational modification] 637910018930 PRD domain; Region: PRD; pfam00874 637910018931 Predicted helix-turn-helix motif with score 1089.000, SD 2.90 at aa 24-45, sequence FTAQDCTCFMQVNRSVISHYLN 637910018932 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 1e-51 637910018933 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 637910018934 PS00017 ATP/GTP-binding site motif A (P-loop). 637910018935 PS00690 DEAH-box subfamily ATP-dependent helicases signature. 637910018936 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 0.00069 637910018937 HMMPfam hit to PF00874, PRD, score 2e-09 637910018938 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 637910018939 active pocket/dimerization site; other site 637910018940 active site 637910018941 phosphorylation site [posttranslational modification] 637910018942 PS00228 Tubulin-beta mRNA autoregulation signal. 637910018943 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 1.2e-11 637910018944 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 637910018945 HMMPfam hit to PF07470, Glycosyl hydrolase, family 88, score 5.1e-60 637910018946 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 637910018947 active site 637910018948 phosphorylation site [posttranslational modification] 637910018949 HMMPfam hit to PF03830, Phosphotransferase system, sorbose subfamily IIB component, score 6.3e-54 637910018950 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 637910018951 HMMPfam hit to PF03609, Phosphotransferase system, sorbose-specific IIC subunit, score 8.6e-44 637910018952 6 transmembrane helices predicted for ROD38601 by TMHMM2.0 at aa 20-42, 47-69, 92-114, 135-157, 177-199 and 206-228 637910018953 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 637910018954 HMMPfam hit to PF03613, Phosphotransferase system, mannose/fructose/sorbose family IID component, score 1e-89 637910018955 5 transmembrane helices predicted for ROD38611 by TMHMM2.0 at aa 126-143, 148-170, 191-213, 233-255 and 262-279 637910018956 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910018957 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 9.8e-07 637910018958 1 transmembrane helix predicted for ROD38621 by TMHMM2.0 at aa 7-29 637910018959 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 637910018960 HMMPfam hit to PF02634, Formate dehydrogenase, subunit FdhD, score 8.7e-138 637910018961 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 637910018962 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 637910018963 [4Fe-4S] binding site [ion binding]; other site 637910018964 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 637910018965 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 637910018966 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 637910018967 molybdopterin cofactor binding site; other site 637910018968 1 transmembrane helix predicted for ROD38641 by TMHMM2.0 at aa 11-33 637910018969 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 region, score 5e-22 637910018970 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 637910018971 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1.5e-36 637910018972 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 3.4e-17 637910018973 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 637910018974 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 637910018975 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 4e-05 637910018976 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910018977 HMMPfam hit to PF09163, Formate dehydrogenase, transmembrane, score 1.5e-26 637910018978 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 637910018979 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 637910018980 HMMPfam hit to PF01292, Cytochrome B561, bacterial, score 0.00039 637910018981 4 transmembrane helices predicted for ROD38661 by TMHMM2.0 at aa 21-40, 55-77, 114-136 and 151-173 637910018982 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 637910018983 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 637910018984 HMMPfam hit to PF04216, Formate dehydrogenase accessory protein, score 1.6e-208 637910018985 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 637910018986 oligomeric interface; other site 637910018987 putative active site [active] 637910018988 homodimer interface [polypeptide binding]; other site 637910018989 HMMPfam hit to PF01850, PilT protein, N-terminal, score 4.2e-15 637910018990 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 637910018991 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 637910018992 Transposase; Region: DDE_Tnp_ISL3; pfam01610 637910018993 HMMPfam hit to PF01610, Transposase, IS204/IS1001/IS1096/IS1165, score 5.5e-34 637910018994 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 637910018995 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 637910018996 substrate binding pocket [chemical binding]; other site 637910018997 HMMPfam hit to PF07859, Alpha/beta hydrolase fold-3, score 4.5e-93 637910018998 PS01174 Lipolytic enzymes G-D-X-G family, serine active site. 637910018999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637910019000 Coenzyme A binding pocket [chemical binding]; other site 637910019001 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 637910019002 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.8e-16 637910019003 Predicted helix-turn-helix motif with score 1295.000, SD 3.60 at aa 107-128, sequence MTLESVARQEGVKRVTCSARED 637910019004 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 637910019005 putative active site [active] 637910019006 dimerization interface [polypeptide binding]; other site 637910019007 putative tRNAtyr binding site [nucleotide binding]; other site 637910019008 HMMPfam hit to PF02580, D-tyrosyl-tRNA(Tyr) deacylase, score 1.6e-88 637910019009 hypothetical protein; Reviewed; Region: PRK01637 637910019010 HMMPfam hit to PF03631, Ribonuclease BN, score 1.6e-74 637910019011 6 transmembrane helices predicted for ROD38741 by TMHMM2.0 at aa 39-61, 101-120, 141-163, 183-200, 212-234 and 244-266 637910019012 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 637910019013 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910019014 motif II; other site 637910019015 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910019016 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 5.8e-14 637910019017 autotransport protein MisL; Provisional; Region: PRK15313 637910019018 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 637910019019 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637910019020 HMMPfam hit to PF03797, Autotransporter beta-domain, score 1.7e-39 637910019021 HMMPfam hit to PF03212, Pertactin, score 2.1e-07 637910019022 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637910019023 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910019024 DNA-binding site [nucleotide binding]; DNA binding site 637910019025 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637910019026 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 4.8e-76 637910019027 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 1.2e-26 637910019028 Predicted helix-turn-helix motif with score 1882.000, SD 5.60 at aa 25-46, sequence MNIDELADLLEVSTQTVRRDIR 637910019029 PS00894 Bacterial regulatory proteins, deoR family signature. 637910019030 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 637910019031 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 637910019032 substrate binding site [chemical binding]; other site 637910019033 ATP binding site [chemical binding]; other site 637910019034 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 1.3e-66 637910019035 PS00584 pfkB family of carbohydrate kinases signature 2. 637910019036 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 637910019037 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 637910019038 HMMPfam hit to PF03446, 6-phosphogluconate dehydrogenase, NAD-binding, score 1.7e-67 637910019039 PS00895 3-hydroxyisobutyrate dehydrogenase signature. 637910019040 Class I aldolases; Region: Aldolase_Class_I; cl17187 637910019041 catalytic residue [active] 637910019042 HMMPfam hit to PF01791, Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase, score 2.1e-64 637910019043 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 637910019044 dimerization interface [polypeptide binding]; other site 637910019045 putative active cleft [active] 637910019046 HMMPfam hit to PF07221, N-acylglucosamine 2-epimerase, score 6.8e-194 637910019047 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 637910019048 active site 637910019049 catalytic residues [active] 637910019050 HMMPfam hit to PF01263, Aldose 1-epimerase, score 9.5e-63 637910019051 Transposase; Region: HTH_Tnp_1; pfam01527 637910019052 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910019053 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910019054 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910019055 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910019056 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910019057 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910019058 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910019059 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910019060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910019061 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910019062 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910019063 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910019064 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910019065 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 637910019066 8 transmembrane helices predicted for ROD38861 by TMHMM2.0 at aa 7-29, 44-63, 72-91, 101-123, 130-152, 188-210, 222-239 and 243-265 637910019067 HMMPfam hit to PF01925, Protein of unknown function DUF81, score 1.7e-22 637910019068 alpha-glucosidase; Provisional; Region: PRK10426 637910019069 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 637910019070 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 637910019071 putative active site [active] 637910019072 putative catalytic site [active] 637910019073 HMMPfam hit to PF01055, Glycoside hydrolase, family 31, score 9.6e-114 637910019074 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 637910019075 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 637910019076 11 transmembrane helices predicted for ROD38881 by TMHMM2.0 at aa 46-68, 89-111, 121-143, 156-178, 188-210, 244-266, 276-295, 308-328, 333-355, 387-404 and 419-441 637910019077 PS00872 Sodium:galactoside symporter family signature. 637910019078 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019079 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019080 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019081 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 637910019082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910019083 12 transmembrane helices predicted for ROD38891 by TMHMM2.0 at aa 17-36, 51-73, 86-108, 118-140, 161-180, 184-206, 236-258, 273-295, 302-324, 328-350, 379-401 and 414-436 637910019084 PS00872 Sodium:galactoside symporter family signature. 637910019085 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019086 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019087 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019088 GTP-binding protein; Provisional; Region: PRK10218 637910019089 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 637910019090 G1 box; other site 637910019091 putative GEF interaction site [polypeptide binding]; other site 637910019092 GTP/Mg2+ binding site [chemical binding]; other site 637910019093 Switch I region; other site 637910019094 G2 box; other site 637910019095 G3 box; other site 637910019096 Switch II region; other site 637910019097 G4 box; other site 637910019098 G5 box; other site 637910019099 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 637910019100 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 637910019101 HMMPfam hit to PF00679, Translation elongation factor EFG/EF2, C-terminal, score 2.7e-20 637910019102 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 3.7e-14 637910019103 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 2.2e-74 637910019104 PS00301 GTP-binding elongation factors signature. 637910019105 PS00017 ATP/GTP-binding site motif A (P-loop). 637910019106 glutamine synthetase; Provisional; Region: glnA; PRK09469 637910019107 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 637910019108 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 637910019109 HMMPfam hit to PF03951, Glutamine synthetase, beta-Grasp, score 1.3e-49 637910019110 PS00180 Glutamine synthetase signature 1. 637910019111 HMMPfam hit to PF00120, Glutamine synthetase, catalytic region, score 4.1e-180 637910019112 PS00181 Glutamine synthetase ATP-binding region signature. 637910019113 PS00182 Glutamine synthetase class-I adenylation site. 637910019114 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 637910019115 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637910019116 putative active site [active] 637910019117 heme pocket [chemical binding]; other site 637910019118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637910019119 dimer interface [polypeptide binding]; other site 637910019120 phosphorylation site [posttranslational modification] 637910019121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910019122 ATP binding site [chemical binding]; other site 637910019123 Mg2+ binding site [ion binding]; other site 637910019124 G-X-G motif; other site 637910019125 HMMPfam hit to PF00989, PAS fold, score 3.1e-07 637910019126 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 7.6e-15 637910019127 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.4e-30 637910019128 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 637910019129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910019130 active site 637910019131 phosphorylation site [posttranslational modification] 637910019132 intermolecular recognition site; other site 637910019133 dimerization interface [polypeptide binding]; other site 637910019134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910019135 Walker A motif; other site 637910019136 ATP binding site [chemical binding]; other site 637910019137 Walker B motif; other site 637910019138 arginine finger; other site 637910019139 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 637910019140 HMMPfam hit to PF00072, Response regulator receiver, score 1.3e-43 637910019141 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 1.2e-147 637910019142 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 637910019143 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 637910019144 PS00688 Sigma-54 interaction domain C-terminal part signature. 637910019145 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 9.7e-17 637910019146 Predicted helix-turn-helix motif with score 1763.000, SD 5.19 at aa 443-464, sequence GHKQEAARLLGWGRNTLTRKLK 637910019147 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 637910019148 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910019149 FeS/SAM binding site; other site 637910019150 HemN C-terminal domain; Region: HemN_C; pfam06969 637910019151 HMMPfam hit to PF06969, HemN, C-terminal, score 1.1e-55 637910019152 HMMPfam hit to PF04055, Radical SAM, score 1.2e-25 637910019153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 637910019154 HMMPfam hit to PF04220, Protein of unknown function DUF414, score 1.1e-88 637910019155 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 637910019156 G1 box; other site 637910019157 GTP/Mg2+ binding site [chemical binding]; other site 637910019158 Switch I region; other site 637910019159 G2 box; other site 637910019160 G3 box; other site 637910019161 Switch II region; other site 637910019162 G4 box; other site 637910019163 G5 box; other site 637910019164 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 6.8e-27 637910019165 PS00017 ATP/GTP-binding site motif A (P-loop). 637910019166 DNA polymerase I; Provisional; Region: PRK05755 637910019167 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 637910019168 active site 637910019169 metal binding site 1 [ion binding]; metal-binding site 637910019170 putative 5' ssDNA interaction site; other site 637910019171 metal binding site 3; metal-binding site 637910019172 metal binding site 2 [ion binding]; metal-binding site 637910019173 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 637910019174 putative DNA binding site [nucleotide binding]; other site 637910019175 putative metal binding site [ion binding]; other site 637910019176 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 637910019177 active site 637910019178 catalytic site [active] 637910019179 substrate binding site [chemical binding]; other site 637910019180 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 637910019181 active site 637910019182 DNA binding site [nucleotide binding] 637910019183 catalytic site [active] 637910019184 HMMPfam hit to PF00476, DNA-directed DNA polymerase, score 1.4e-229 637910019185 PS00447 DNA polymerase family A signature. 637910019186 HMMPfam hit to PF01612, 3'-5' exonuclease, score 1.2e-68 637910019187 HMMPfam hit to PF01367, 5'-3' exonuclease, score 2.9e-54 637910019188 HMMPfam hit to PF02739, 5'-3' exonuclease, score 9.7e-96 637910019189 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 637910019190 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 637910019191 putative acyl-acceptor binding pocket; other site 637910019192 1 transmembrane helix predicted for ROD38981 by TMHMM2.0 at aa 21-43 637910019193 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 3.1e-33 637910019194 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019195 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 637910019196 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 637910019197 catalytic residues [active] 637910019198 hinge region; other site 637910019199 alpha helical domain; other site 637910019200 HMMPfam hit to PF01323, DSBA oxidoreductase, score 1.4e-54 637910019201 PS00194 Thioredoxin family active site. 637910019202 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 637910019203 serine/threonine protein kinase; Provisional; Region: PRK11768 637910019204 HMMPfam hit to PF01636, Aminoglycoside phosphotransferase, score 1.1e-40 637910019205 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 637910019206 HMMPfam hit to PF06288, Protein of unknown function DUF1040, score 2e-62 637910019207 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 637910019208 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 637910019209 GTP binding site; other site 637910019210 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 637910019211 Walker A motif; other site 637910019212 HMMPfam hit to PF03205, Molybdopterin-guanine dinucleotide biosynthesis MobB region, score 5e-56 637910019213 PS00017 ATP/GTP-binding site motif A (P-loop). 637910019214 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 637910019215 PS00201 Flavodoxin signature. 637910019216 potassium transporter; Provisional; Region: PRK10750 637910019217 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 637910019218 HMMPfam hit to PF02386, Cation transporter score 5.3e-121 637910019219 10 transmembrane helices predicted for ROD39061 by TMHMM2.0 at aa 9-31, 35-57, 69-91, 133-155, 185-207, 238-260, 273-295, 332-354, 396-418 and 456-478 637910019220 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019221 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019222 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019223 hypothetical protein; Provisional; Region: PRK11568 637910019224 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 637910019225 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 637910019226 HMMPfam hit to PF09186, Region of unknown function DUF1949, score 2.6e-17 637910019227 HMMPfam hit to PF01205, Protein of unknown function UPF0029, N-terminal, score 5.5e-63 637910019228 PS00910 Uncharacterized protein family UPF0029 signature. 637910019229 proline dipeptidase; Provisional; Region: PRK13607 637910019230 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 637910019231 active site 637910019232 HMMPfam hit to PF00557, Peptidase M24, catalytic core, score 6e-107 637910019233 PS00491 Aminopeptidase P and proline dipeptidase signature. 637910019234 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 637910019235 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 637910019236 substrate binding site [chemical binding]; other site 637910019237 oxyanion hole (OAH) forming residues; other site 637910019238 trimer interface [polypeptide binding]; other site 637910019239 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 637910019240 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 637910019241 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 637910019242 HMMPfam hit to PF00378, Crotonase, core, score 2.4e-86 637910019243 PS00166 Enoyl-CoA hydratase/isomerase signature. 637910019244 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019245 HMMPfam hit to PF02737, 3-hydroxyacyl-CoA dehydrogenase, NAD-binding, score 2.6e-89 637910019246 PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 637910019247 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 5.8e-37 637910019248 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 0.00015 637910019249 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 637910019250 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 637910019251 dimer interface [polypeptide binding]; other site 637910019252 active site 637910019253 HMMPfam hit to PF00108, Thiolase, score 1.4e-143 637910019254 PS00098 Thiolases acyl-enzyme intermediate signature. 637910019255 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 637910019256 HMMPfam hit to PF02803, Thiolase, score 4.8e-89 637910019257 PS00737 Thiolases signature 2. 637910019258 PS00099 Thiolases active site. 637910019259 FMN reductase; Validated; Region: fre; PRK08051 637910019260 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 637910019261 FAD binding pocket [chemical binding]; other site 637910019262 FAD binding motif [chemical binding]; other site 637910019263 phosphate binding motif [ion binding]; other site 637910019264 beta-alpha-beta structure motif; other site 637910019265 NAD binding pocket [chemical binding]; other site 637910019266 HMMPfam hit to PF00175, Oxidoreductase FAD/NAD(P)-binding, score 9.2e-32 637910019267 HMMPfam hit to PF00970, Oxidoreductase FAD-binding region, score 6.8e-13 637910019268 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 637910019269 HMMPfam hit to PF01977, Carboxylyase-related, score 1.2e-253 637910019270 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 637910019271 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 637910019272 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 637910019273 HMMPfam hit to PF02357, Transcription antitermination protein, NusG, N-terminal, score 2.2e-29 637910019274 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 637910019275 active site 637910019276 HMMPfam hit to PF01026, Deoxyribonuclease, TatD-related, score 2e-104 637910019277 PS01091 Uncharacterized protein family UPF0006 signature 3. 637910019278 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 637910019279 6 transmembrane helices predicted for ROD39161 by TMHMM2.0 at aa 20-42, 74-96, 108-130, 160-182, 195-212 and 216-238 637910019280 HMMPfam hit to PF00902, Sec-independent periplasmic protein translocase, score 5.4e-100 637910019281 PS01218 Uncharacterized protein family UPF0032 signature. 637910019282 sec-independent translocase; Provisional; Region: PRK01770 637910019283 1 transmembrane helix predicted for ROD39171 by TMHMM2.0 at aa 4-21 637910019284 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 637910019285 HMMPfam hit to PF02416, Bacterial sec-independent translocation protein mttA/Hcf106, score 8.1e-13 637910019286 1 transmembrane helix predicted for ROD39181 by TMHMM2.0 at aa 12-34 637910019287 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 637910019288 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 637910019289 2 transmembrane helices predicted for ROD39191 by TMHMM2.0 at aa 501-518 and 523-542 637910019290 HMMPfam hit to PF03109, ABC-1, score 2.3e-58 637910019291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 637910019292 SCP-2 sterol transfer family; Region: SCP2; pfam02036 637910019293 HMMPfam hit to PF06843, Protein of unknown function DUF1243, score 1.5e-90 637910019294 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 637910019295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910019296 S-adenosylmethionine binding site [chemical binding]; other site 637910019297 HMMPfam hit to PF01209, UbiE/COQ5 methyltransferase, score 9.4e-179 637910019298 PS01184 ubiE/COQ5 methyltransferase family signature 2. 637910019299 PS01183 ubiE/COQ5 methyltransferase family signature 1. 637910019300 DNA recombination protein RmuC; Provisional; Region: PRK10361 637910019301 RmuC family; Region: RmuC; pfam02646 637910019302 HMMPfam hit to PF02646, RmuC, score 2.5e-157 637910019303 1 transmembrane helix predicted for ROD39221 by TMHMM2.0 at aa 5-24 637910019304 uridine phosphorylase; Provisional; Region: PRK11178 637910019305 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 637910019306 HMMPfam hit to PF01048, Nucleoside phosphorylase, score 4.1e-111 637910019307 PS01232 Purine and other phosphorylases family 1 signature. 637910019308 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 637910019309 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 637910019310 HMMPfam hit to PF01738, Dienelactone hydrolase, score 1.5e-108 637910019311 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 637910019312 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 637910019313 THF binding site; other site 637910019314 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 637910019315 substrate binding site [chemical binding]; other site 637910019316 THF binding site; other site 637910019317 zinc-binding site [ion binding]; other site 637910019318 HMMPfam hit to PF01717, Methionine synthase, vitamin-B12 independent, score 7.7e-230 637910019319 HMMPfam hit to PF08267, Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal, score 1.6e-194 637910019320 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 637910019321 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910019322 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 637910019323 putative dimerization interface [polypeptide binding]; other site 637910019324 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.1e-16 637910019325 Predicted helix-turn-helix motif with score 1573.000, SD 4.54 at aa 17-38, sequence GSLAAAAATLHQTQSALSHQFS 637910019326 PS00044 Bacterial regulatory proteins, lysR family signature. 637910019327 HMMPfam hit to PF03466, LysR, substrate-binding, score 3.8e-47 637910019328 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 637910019329 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 4.6e-09 637910019330 10 transmembrane helices predicted for ROD39271 by TMHMM2.0 at aa 2-24, 28-47, 54-76, 80-102, 109-128, 138-157, 170-192, 202-224, 231-253 and 258-275 637910019331 putative hydrolase; Provisional; Region: PRK10976 637910019332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910019333 active site 637910019334 motif I; other site 637910019335 motif II; other site 637910019336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910019337 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 9.4e-83 637910019338 PS01229 Hypothetical cof family signature 2. 637910019339 PS01228 Hypothetical cof family signature 1. 637910019340 lysophospholipase L2; Provisional; Region: PRK10749 637910019341 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 637910019342 HMMPfam hit to PF00561, Alpha/beta hydrolase fold-1, score 7.6e-39 637910019343 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 637910019344 6 transmembrane helices predicted for ROD39301 by TMHMM2.0 at aa 5-27, 40-62, 77-94, 115-137, 147-169 and 188-205 637910019345 HMMPfam hit to PF01810, Lysine exporter protein (LYSE/YGGA), score 7.2e-61 637910019346 threonine efflux system; Provisional; Region: PRK10229 637910019347 HMMPfam hit to PF01810, Lysine exporter protein (LYSE/YGGA), score 2e-78 637910019348 6 transmembrane helices predicted for ROD39311 by TMHMM2.0 at aa 4-26, 42-64, 68-87, 119-141, 151-173 and 186-205 637910019349 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 637910019350 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637910019351 ATP binding site [chemical binding]; other site 637910019352 putative Mg++ binding site [ion binding]; other site 637910019353 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637910019354 nucleotide binding region [chemical binding]; other site 637910019355 ATP-binding site [chemical binding]; other site 637910019356 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 637910019357 Helicase and RNase D C-terminal; Region: HRDC; smart00341 637910019358 HMMPfam hit to PF00570, Helicase and RNase D C-terminal, HRDC, score 8.6e-35 637910019359 HMMPfam hit to PF02008, Zinc finger, CXXC-type, score 0.0001 637910019360 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 4.4e-30 637910019361 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 3.6e-36 637910019362 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019363 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 637910019364 dimerization interface [polypeptide binding]; other site 637910019365 substrate binding site [chemical binding]; other site 637910019366 active site 637910019367 calcium binding site [ion binding]; other site 637910019368 HMMPfam hit to PF02253, Phospholipase A1, score 2.9e-170 637910019369 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 637910019370 CoenzymeA binding site [chemical binding]; other site 637910019371 subunit interaction site [polypeptide binding]; other site 637910019372 PHB binding site; other site 637910019373 HMMPfam hit to PF03061, Thioesterase superfamily, score 8e-16 637910019374 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 637910019375 EamA-like transporter family; Region: EamA; cl17759 637910019376 10 transmembrane helices predicted for ROD39351 by TMHMM2.0 at aa 12-34, 38-60, 73-95, 100-122, 129-146, 150-167, 180-197, 212-234, 239-261 and 271-290 637910019377 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 6.2e-11 637910019378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 637910019379 Transposase; Region: DEDD_Tnp_IS110; pfam01548 637910019380 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 637910019381 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.2e-27 637910019382 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 1.2e-17 637910019383 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 637910019384 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 637910019385 Cl binding site [ion binding]; other site 637910019386 oligomer interface [polypeptide binding]; other site 637910019387 HMMPfam hit to PF01544, Mg2+ transporter protein, CorA-like, score 1.1e-101 637910019388 2 transmembrane helices predicted for ROD39371 by TMHMM2.0 at aa 255-273 and 288-310 637910019389 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 637910019390 Part of AAA domain; Region: AAA_19; pfam13245 637910019391 Family description; Region: UvrD_C_2; pfam13538 637910019392 HMMPfam hit to PF00580, DNA helicase, UvrD/REP type, score 2.4e-233 637910019393 PS00017 ATP/GTP-binding site motif A (P-loop). 637910019394 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 637910019395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910019396 motif II; other site 637910019397 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 9.2e-24 637910019398 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 637910019399 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637910019400 active site 637910019401 DNA binding site [nucleotide binding] 637910019402 Int/Topo IB signature motif; other site 637910019403 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 4e-61 637910019404 HMMPfam hit to PF02899, Integrase, N-terminal SAM-like, phage, score 4e-32 637910019405 hypothetical protein; Provisional; Region: PRK10963 637910019406 HMMPfam hit to PF04340, Protein of unknown function DUF484, score 5.5e-114 637910019407 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 637910019408 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 637910019409 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 637910019410 HMMPfam hit to PF01678, Diaminopimelate epimerase, score 6.4e-50 637910019411 HMMPfam hit to PF01678, Diaminopimelate epimerase, score 2.4e-56 637910019412 PS01326 Diaminopimelate epimerase signature. 637910019413 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 637910019414 1 transmembrane helix predicted for ROD39431 by TMHMM2.0 at aa 7-29 637910019415 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019416 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 637910019417 putative iron binding site [ion binding]; other site 637910019418 HMMPfam hit to PF01491, Frataxin-like, score 5.3e-71 637910019419 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 637910019420 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 637910019421 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 637910019422 HMMPfam hit to PF01295, Adenylate cyclase, class-I, score 0 637910019423 PS01093 Adenylate cyclases class-I signature 2. 637910019424 PS01092 Adenylate cyclases class-I signature 1. 637910019425 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019426 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 637910019427 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 637910019428 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 637910019429 domain interfaces; other site 637910019430 active site 637910019431 HMMPfam hit to PF01379, Tetrapyrrole biosynthesis, hydroxymethylbilane synthase, score 1.5e-143 637910019432 HMMPfam hit to PF03900, Tetrapyrrole biosynthesis, hydroxymethylbilane synthase, score 2.9e-32 637910019433 PS00533 Porphobilinogen deaminase cofactor-binding site. 637910019434 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 637910019435 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 637910019436 active site 637910019437 HMMPfam hit to PF02602, Tetrapyrrole biosynthesis, uroporphyrinogen III synthase, score 2.9e-64 637910019438 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 637910019439 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 637910019440 HMMPfam hit to PF04375, HemX, score 1.7e-183 637910019441 1 transmembrane helix predicted for ROD39481 by TMHMM2.0 at aa 36-58 637910019442 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 637910019443 HemY protein N-terminus; Region: HemY_N; pfam07219 637910019444 HMMPfam hit to PF07219, HemY, N-terminal, score 4.7e-66 637910019445 2 transmembrane helices predicted for ROD39491 by TMHMM2.0 at aa 5-27 and 42-64 637910019446 PS00215 Mitochondrial energy transfer proteins signature. 637910019447 HMMPfam hit to PF07719, Tetratricopeptide TPR2, score 1.4e-06 637910019448 putative transport protein YifK; Provisional; Region: PRK10746 637910019449 HMMPfam hit to PF00324, Amino acid permease-associated region, score 1.6e-127 637910019450 12 transmembrane helices predicted for ROD39511 by TMHMM2.0 at aa 19-36, 40-59, 93-115, 125-147, 154-176, 191-213, 240-262, 277-299, 331-353, 358-380, 401-423 and 428-450 637910019451 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019452 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 637910019453 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019454 PS00218 Amino acid permeases signature. 637910019455 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 637910019456 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 637910019457 HMMPfam hit to PF03808, Glycosyl transferase WecB/TagA/CpsF, score 3e-87 637910019458 putative common antigen polymerase; Provisional; Region: PRK02975 637910019459 HMMPfam hit to PF06899, WzyE, score 0 637910019460 11 transmembrane helices predicted for ROD39531 by TMHMM2.0 at aa 4-26, 33-55, 70-89, 116-138, 153-175, 182-201, 205-224, 226-245, 337-359, 380-399 and 409-431 637910019461 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019462 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 637910019463 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019464 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 637910019465 HMMPfam hit to PF07429, 4-alpha-L-fucosyltransferase, score 6.3e-262 637910019466 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 637910019467 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 637910019468 12 transmembrane helices predicted for ROD39551 by TMHMM2.0 at aa 13-35, 45-67, 79-101, 116-138, 145-167, 172-194, 220-242, 262-284, 297-319, 334-356, 363-385 and 390-412 637910019469 HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 3.6e-05 637910019470 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 637910019471 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 637910019472 inhibitor-cofactor binding pocket; inhibition site 637910019473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910019474 catalytic residue [active] 637910019475 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 1.2e-84 637910019476 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019477 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 637910019478 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 3.5e-08 637910019479 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 637910019480 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 637910019481 substrate binding site; other site 637910019482 tetramer interface; other site 637910019483 HMMPfam hit to PF00483, Nucleotidyl transferase, score 1e-115 637910019484 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 637910019485 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 637910019486 NAD binding site [chemical binding]; other site 637910019487 substrate binding site [chemical binding]; other site 637910019488 homodimer interface [polypeptide binding]; other site 637910019489 active site 637910019490 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 8.1e-94 637910019491 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 637910019492 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 637910019493 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 637910019494 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 637910019495 HMMPfam hit to PF03720, UDP-glucose/GDP-mannose dehydrogenase, C-terminal, score 4.3e-29 637910019496 HMMPfam hit to PF00984, UDP-glucose/GDP-mannose dehydrogenase, dimerisation, score 1e-45 637910019497 PS00678 Trp-Asp (WD) repeats signature. 637910019498 HMMPfam hit to PF03721, UDP-glucose/GDP-mannose dehydrogenase, N-terminal, score 5.3e-93 637910019499 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910019500 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 637910019501 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 637910019502 active site 637910019503 homodimer interface [polypeptide binding]; other site 637910019504 HMMPfam hit to PF02350, UDP-N-acetylglucosamine 2-epimerase, score 7.1e-201 637910019505 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 637910019506 Chain length determinant protein; Region: Wzz; pfam02706 637910019507 2 transmembrane helices predicted for ROD39621 by TMHMM2.0 at aa 29-51 and 323-342 637910019508 HMMPfam hit to PF02706, Lipopolysaccharide biosynthesis, score 2.5e-16 637910019509 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 637910019510 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 637910019511 Mg++ binding site [ion binding]; other site 637910019512 putative catalytic motif [active] 637910019513 substrate binding site [chemical binding]; other site 637910019514 11 transmembrane helices predicted for ROD39631 by TMHMM2.0 at aa 5-24, 45-67, 72-89, 105-127, 131-153, 160-179, 184-206, 213-232, 242-261, 294-311 and 321-338 637910019515 HMMPfam hit to PF00953, Glycosyl transferase, family 4, score 1.2e-10 637910019516 transcription termination factor Rho; Provisional; Region: rho; PRK09376 637910019517 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 637910019518 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 637910019519 RNA binding site [nucleotide binding]; other site 637910019520 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 637910019521 multimer interface [polypeptide binding]; other site 637910019522 Walker A motif; other site 637910019523 ATP binding site [chemical binding]; other site 637910019524 Walker B motif; other site 637910019525 HMMPfam hit to PF00006, ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding, score 6.8e-79 637910019526 PS00017 ATP/GTP-binding site motif A (P-loop). 637910019527 PS00464 Ribosomal protein L22 signature. 637910019528 HMMPfam hit to PF07497, Rho termination factor, RNA-binding, score 2.9e-59 637910019529 HMMPfam hit to PF07498, Rho termination factor, N-terminal, score 2e-20 637910019530 putative rho operon leader peptide; Provisional; Region: PRK09979 637910019531 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 637910019532 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 637910019533 catalytic residues [active] 637910019534 HMMPfam hit to PF00085, Thioredoxin domain, score 9.7e-53 637910019535 PS00194 Thioredoxin family active site. 637910019536 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 637910019537 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 637910019538 ATP binding site [chemical binding]; other site 637910019539 Mg++ binding site [ion binding]; other site 637910019540 motif III; other site 637910019541 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637910019542 nucleotide binding region [chemical binding]; other site 637910019543 ATP-binding site [chemical binding]; other site 637910019544 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 6.8e-62 637910019545 PS00017 ATP/GTP-binding site motif A (P-loop). 637910019546 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 637910019547 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 4.9e-34 637910019548 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019549 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 637910019550 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 637910019551 HMMPfam hit to PF02541, Ppx/GppA phosphatase, score 6e-134 637910019552 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019553 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 637910019554 Part of AAA domain; Region: AAA_19; pfam13245 637910019555 Family description; Region: UvrD_C_2; pfam13538 637910019556 HMMPfam hit to PF00580, DNA helicase, UvrD/REP type, score 3e-228 637910019557 PS00017 ATP/GTP-binding site motif A (P-loop). 637910019558 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 637910019559 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 637910019560 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 637910019561 HMMPfam hit to PF05651, sugar diacid recognition, score 1.1e-116 637910019562 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 637910019563 fructuronate transporter; Provisional; Region: PRK10034; cl15264 637910019564 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 637910019565 12 transmembrane helices predicted for ROD39711 by TMHMM2.0 at aa 2-21, 31-53, 66-85, 100-122, 135-157, 172-194, 220-237, 241-263, 275-297, 319-341, 348-370 and 402-421 637910019566 HMMPfam hit to PF03600, Divalent ion symporter, score 2e-07 637910019567 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 637910019568 HMMPfam hit to PF02595, Glycerate kinase, score 4.1e-232 637910019569 PS00017 ATP/GTP-binding site motif A (P-loop). 637910019570 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 637910019571 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 637910019572 HMMPfam hit to PF00639, Peptidyl-prolyl cis-trans isomerase, PpiC-type, score 2.2e-45 637910019573 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 637910019574 ketol-acid reductoisomerase; Validated; Region: PRK05225 637910019575 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 637910019576 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 637910019577 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 637910019578 HMMPfam hit to PF01450, Acetohydroxy acid isomeroreductase C-terminal, score 3.8e-134 637910019579 HMMPfam hit to PF07991, Acetohydroxy acid isomeroreductase, catalytic, score 3.3e-85 637910019580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910019581 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 637910019582 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 637910019583 putative dimerization interface [polypeptide binding]; other site 637910019584 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 3.7e-23 637910019585 Predicted helix-turn-helix motif with score 1925.000, SD 5.74 at aa 16-37, sequence RHFGRSARAMHVSPSTLSRQIQ 637910019586 PS00044 Bacterial regulatory proteins, lysR family signature. 637910019587 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.5e-31 637910019588 threonine dehydratase; Reviewed; Region: PRK09224 637910019589 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 637910019590 tetramer interface [polypeptide binding]; other site 637910019591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910019592 catalytic residue [active] 637910019593 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 637910019594 putative Ile/Val binding site [chemical binding]; other site 637910019595 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 637910019596 putative Ile/Val binding site [chemical binding]; other site 637910019597 HMMPfam hit to PF00585, threonine dehydratase, C-terminal, score 1.4e-47 637910019598 HMMPfam hit to PF00585, threonine dehydratase, C-terminal, score 2.2e-44 637910019599 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 5.4e-107 637910019600 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 637910019601 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 637910019602 HMMPfam hit to PF00920, Dihydroxy-acid and 6-phosphogluconate dehydratase, score 0 637910019603 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 637910019604 PS00017 ATP/GTP-binding site motif A (P-loop). 637910019605 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 637910019606 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 637910019607 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 637910019608 homodimer interface [polypeptide binding]; other site 637910019609 substrate-cofactor binding pocket; other site 637910019610 catalytic residue [active] 637910019611 HMMPfam hit to PF01063, Aminotransferase, class IV, score 2e-142 637910019612 PS00770 Aminotransferases class-IV signature. 637910019613 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 637910019614 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 637910019615 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 637910019616 PYR/PP interface [polypeptide binding]; other site 637910019617 dimer interface [polypeptide binding]; other site 637910019618 TPP binding site [chemical binding]; other site 637910019619 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637910019620 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 637910019621 TPP-binding site [chemical binding]; other site 637910019622 dimer interface [polypeptide binding]; other site 637910019623 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-terminal TPP-binding, score 1.7e-77 637910019624 PS00187 Thiamine pyrophosphate enzymes signature. 637910019625 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central region, score 8.8e-64 637910019626 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-terminal TPP binding region, score 6.8e-106 637910019627 PS00044 Bacterial regulatory proteins, lysR family signature. 637910019628 ilvG operon leader peptide; Provisional; Region: PRK10424 637910019629 HMMPfam hit to PF08046, IlvGEDA operon leader peptide, score 1.9e-16 637910019630 1 transmembrane helix predicted for ROD39802 by TMHMM2.0 at aa 7-29 637910019631 pseudogene, truncated by premature stop codon 637910019632 HMMPfam hit to PF01078, Magnesium chelatase, ChlI subunit, score 4.6e-136 637910019633 hypothetical protein; Provisional; Region: PRK11027 637910019634 HMMPfam hit to PF04219, Protein of unknown function DUF413, score 1.5e-45 637910019635 transcriptional regulator HdfR; Provisional; Region: PRK03601 637910019636 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910019637 LysR substrate binding domain; Region: LysR_substrate; pfam03466 637910019638 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 4.2e-20 637910019639 Predicted helix-turn-helix motif with score 1427.000, SD 4.05 at aa 16-37, sequence RHFGRAAEALYLTQSAVSFRIR 637910019640 PS00044 Bacterial regulatory proteins, lysR family signature. 637910019641 transcriptional regulator NanR; Provisional; Region: PRK03837 637910019642 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910019643 DNA-binding site [nucleotide binding]; DNA binding site 637910019644 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 637910019645 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 8.4e-23 637910019646 PS00043 Bacterial regulatory proteins, gntR family signature. 637910019647 Predicted helix-turn-helix motif with score 1106.000, SD 2.95 at aa 38-59, sequence PGEIELGDQFGVSRTAVREAVK 637910019648 HMMPfam hit to PF07729, GntR, C-terminal, score 1.3e-26 637910019649 putative transporter; Provisional; Region: PRK10504 637910019650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910019651 putative substrate translocation pore; other site 637910019652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910019653 14 transmembrane helices predicted for ROD39851 by TMHMM2.0 at aa 11-33, 48-70, 77-99, 103-125, 137-159, 164-181, 201-218, 222-244, 264-286, 291-313, 325-347, 351-373, 394-416 and 431-450 637910019654 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 3e-48 637910019655 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019656 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910019657 transcriptional repressor RbsR; Provisional; Region: PRK10423 637910019658 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910019659 DNA binding site [nucleotide binding] 637910019660 domain linker motif; other site 637910019661 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 637910019662 dimerization interface [polypeptide binding]; other site 637910019663 ligand binding site [chemical binding]; other site 637910019664 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 1.1e-21 637910019665 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 1e-13 637910019666 Predicted helix-turn-helix motif with score 2156.000, SD 6.53 at aa 2-23, sequence ATMKDVARLAGVSTSTVSHVIN 637910019667 PS00356 Bacterial regulatory proteins, lacI family signature. 637910019668 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 637910019669 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 637910019670 substrate binding site [chemical binding]; other site 637910019671 dimer interface [polypeptide binding]; other site 637910019672 ATP binding site [chemical binding]; other site 637910019673 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 6.6e-90 637910019674 PS00584 pfkB family of carbohydrate kinases signature 2. 637910019675 PS00583 pfkB family of carbohydrate kinases signature 1. 637910019676 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 637910019677 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 637910019678 ligand binding site [chemical binding]; other site 637910019679 dimerization interface [polypeptide binding]; other site 637910019680 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 1.5e-09 637910019681 PS00017 ATP/GTP-binding site motif A (P-loop). 637910019682 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637910019683 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 637910019684 TM-ABC transporter signature motif; other site 637910019685 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 9e-73 637910019686 8 transmembrane helices predicted for ROD39891 by TMHMM2.0 at aa 21-43, 53-72, 74-93, 97-119, 126-145, 165-187, 221-243 and 275-297 637910019687 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 637910019688 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 637910019689 Walker A/P-loop; other site 637910019690 ATP binding site [chemical binding]; other site 637910019691 Q-loop/lid; other site 637910019692 ABC transporter signature motif; other site 637910019693 Walker B; other site 637910019694 D-loop; other site 637910019695 H-loop/switch region; other site 637910019696 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 637910019697 HMMPfam hit to PF00005, ABC transporter related, score 4.9e-30 637910019698 PS00211 ABC transporters family signature. 637910019699 HMMPfam hit to PF00005, ABC transporter related, score 5.5e-47 637910019700 PS00017 ATP/GTP-binding site motif A (P-loop). 637910019701 D-ribose pyranase; Provisional; Region: PRK11797 637910019702 HMMPfam hit to PF05025, RbsD or FucU transport, score 1.7e-86 637910019703 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 637910019704 potassium uptake protein; Region: kup; TIGR00794 637910019705 HMMPfam hit to PF02705, K+ potassium transporter score 0 637910019706 12 transmembrane helices predicted for ROD39921 by TMHMM2.0 at aa 7-29, 49-71, 102-124, 134-156, 168-190, 210-232, 245-267, 287-309, 335-357, 363-385, 392-414 and 419-441 637910019707 regulatory ATPase RavA; Provisional; Region: PRK13531 637910019708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910019709 Walker A motif; other site 637910019710 ATP binding site [chemical binding]; other site 637910019711 Walker B motif; other site 637910019712 arginine finger; other site 637910019713 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 637910019714 HMMPfam hit to PF07728, ATPase associated with various cellular activities, AAA-5, score 3.2e-48 637910019715 hypothetical protein; Provisional; Region: yieM; PRK10997 637910019716 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 637910019717 metal ion-dependent adhesion site (MIDAS); other site 637910019718 Predicted helix-turn-helix motif with score 1030.000, SD 2.70 at aa 210-231, sequence PELKQLAEQLGRSREARSVPRK 637910019719 HMMPfam hit to PF05762, vWA containing CoxE-like, score 0.0023 637910019720 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 637910019721 dimer interface [polypeptide binding]; other site 637910019722 active site 637910019723 HMMPfam hit to PF03590, Aspartate--ammonia ligase, score 1.2e-180 637910019724 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 637910019725 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 637910019726 putative DNA binding site [nucleotide binding]; other site 637910019727 putative Zn2+ binding site [ion binding]; other site 637910019728 AsnC family; Region: AsnC_trans_reg; pfam01037 637910019729 Predicted helix-turn-helix motif with score 1689.000, SD 4.94 at aa 23-44, sequence TAYAELAKQFGVSPGTIHVRVE 637910019730 PS00519 Bacterial regulatory proteins, asnC family signature. 637910019731 HMMPfam hit to PF01037, Bacterial regulatory proteins, AsnC/Lrp, score 3.4e-20 637910019732 FMN-binding protein MioC; Provisional; Region: PRK09004 637910019733 HMMPfam hit to PF00258, Flavodoxin/nitric oxide synthase, score 3.2e-25 637910019734 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 637910019735 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 637910019736 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 637910019737 HMMPfam hit to PF01134, Glucose-inhibited division protein A, score 1.7e-277 637910019738 PS01280 Glucose inhibited division protein A family signature 1. 637910019739 PS01281 Glucose inhibited division protein A family signature 2. 637910019740 Predicted helix-turn-helix motif with score 1277.000, SD 3.54 at aa 596-617, sequence VSIGQASRISGVTPAAISILLV 637910019741 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 637910019742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910019743 S-adenosylmethionine binding site [chemical binding]; other site 637910019744 HMMPfam hit to PF02527, Glucose inhibited division protein, score 2.1e-91 637910019745 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 637910019746 HMMPfam hit to PF03899, ATPase, F0 complex, subunit I, proteobacteria-type, score 2e-66 637910019747 4 transmembrane helices predicted for ROD40011 by TMHMM2.0 at aa 15-32, 37-59, 74-96 and 101-123 637910019748 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 637910019749 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 637910019750 5 transmembrane helices predicted for ROD40021 by TMHMM2.0 at aa 36-58, 101-123, 147-166, 211-233 and 243-265 637910019751 HMMPfam hit to PF00119, ATPase, F0 complex, subunit A, score 2.4e-96 637910019752 PS00449 ATP synthase a subunit signature. 637910019753 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 637910019754 HMMPfam hit to PF00137, ATPase, F0/V0 complex, subunit C, score 1.2e-24 637910019755 2 transmembrane helices predicted for ROD40031 by TMHMM2.0 at aa 10-32 and 53-75 637910019756 PS00605 ATP synthase c subunit signature. 637910019757 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 637910019758 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 637910019759 1 transmembrane helix predicted for ROD40041 by TMHMM2.0 at aa 5-27 637910019760 HMMPfam hit to PF00430, ATPase, F0 complex, subunit B/B', bacterial and chloroplast, score 1.3e-44 637910019761 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 637910019762 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 637910019763 HMMPfam hit to PF00213, ATPase, F1 complex, OSCP/delta subunit, score 4.9e-76 637910019764 PS00389 ATP synthase delta (OSCP) subunit signature. 637910019765 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 637910019766 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 637910019767 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 637910019768 beta subunit interaction interface [polypeptide binding]; other site 637910019769 Walker A motif; other site 637910019770 ATP binding site [chemical binding]; other site 637910019771 Walker B motif; other site 637910019772 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 637910019773 HMMPfam hit to PF02874, ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal, score 3.1e-16 637910019774 HMMPfam hit to PF00006, ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding, score 9.2e-120 637910019775 PS00017 ATP/GTP-binding site motif A (P-loop). 637910019776 PS00152 ATP synthase alpha and beta subunits signature. 637910019777 HMMPfam hit to PF00306, ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal, score 1.2e-29 637910019778 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 637910019779 core domain interface [polypeptide binding]; other site 637910019780 delta subunit interface [polypeptide binding]; other site 637910019781 epsilon subunit interface [polypeptide binding]; other site 637910019782 HMMPfam hit to PF00231, ATPase, F1 complex, gamma subunit, score 3.1e-178 637910019783 PS00153 ATP synthase gamma subunit signature. 637910019784 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 637910019785 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 637910019786 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 637910019787 alpha subunit interaction interface [polypeptide binding]; other site 637910019788 Walker A motif; other site 637910019789 ATP binding site [chemical binding]; other site 637910019790 Walker B motif; other site 637910019791 inhibitor binding site; inhibition site 637910019792 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 637910019793 HMMPfam hit to PF02874, ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal, score 2.3e-26 637910019794 HMMPfam hit to PF00006, ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding, score 8.3e-95 637910019795 PS00017 ATP/GTP-binding site motif A (P-loop). 637910019796 PS00152 ATP synthase alpha and beta subunits signature. 637910019797 HMMPfam hit to PF00306, ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal, score 6e-53 637910019798 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 637910019799 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 637910019800 gamma subunit interface [polypeptide binding]; other site 637910019801 epsilon subunit interface [polypeptide binding]; other site 637910019802 LBP interface [polypeptide binding]; other site 637910019803 HMMPfam hit to PF02823, ATPase, F1 complex, delta/subunit epsilon, score 2.3e-39 637910019804 HMMPfam hit to PF00401, ATPase, F1 complex, delta/subunit epsilon, score 1.4e-12 637910019805 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 637910019806 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 637910019807 Substrate binding site; other site 637910019808 Mg++ binding site; other site 637910019809 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 637910019810 active site 637910019811 substrate binding site [chemical binding]; other site 637910019812 CoA binding site [chemical binding]; other site 637910019813 HMMPfam hit to PF01128, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, score 2.1e-07 637910019814 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.033 637910019815 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.056 637910019816 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 22 637910019817 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 2.1 637910019818 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 26 637910019819 PS00101 Hexapeptide-repeat containing-transferases signature. 637910019820 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 8.6 637910019821 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 637910019822 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 637910019823 glutaminase active site [active] 637910019824 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 637910019825 dimer interface [polypeptide binding]; other site 637910019826 active site 637910019827 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 637910019828 dimer interface [polypeptide binding]; other site 637910019829 active site 637910019830 PS00443 Glutamine amidotransferases class-II active site. 637910019831 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 2e-62 637910019832 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 3.3e-42 637910019833 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 1.7e-38 637910019834 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 637910019835 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910019836 HMMPfam hit to PF01609, Transposase, IS4-like, score 3.6e-29 637910019837 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637910019838 1 transmembrane helix predicted for ROD40131 by TMHMM2.0 at aa 7-29 637910019839 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 6.7e-33 637910019840 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 637910019841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910019842 dimer interface [polypeptide binding]; other site 637910019843 conserved gate region; other site 637910019844 putative PBP binding loops; other site 637910019845 ABC-ATPase subunit interface; other site 637910019846 6 transmembrane helices predicted for ROD40141 by TMHMM2.0 at aa 21-43, 78-100, 112-134, 166-188, 227-249 and 282-304 637910019847 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3.5e-09 637910019848 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910019849 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 637910019850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910019851 dimer interface [polypeptide binding]; other site 637910019852 conserved gate region; other site 637910019853 putative PBP binding loops; other site 637910019854 ABC-ATPase subunit interface; other site 637910019855 6 transmembrane helices predicted for ROD40151 by TMHMM2.0 at aa 29-51, 88-110, 123-145, 150-169, 201-223 and 268-290 637910019856 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3.6e-40 637910019857 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910019858 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 637910019859 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 637910019860 Walker A/P-loop; other site 637910019861 ATP binding site [chemical binding]; other site 637910019862 Q-loop/lid; other site 637910019863 ABC transporter signature motif; other site 637910019864 Walker B; other site 637910019865 D-loop; other site 637910019866 H-loop/switch region; other site 637910019867 HMMPfam hit to PF00005, ABC transporter related, score 1.3e-70 637910019868 PS00017 ATP/GTP-binding site motif A (P-loop). 637910019869 PS00211 ABC transporters family signature. 637910019870 transcriptional regulator PhoU; Provisional; Region: PRK11115 637910019871 PhoU domain; Region: PhoU; pfam01895 637910019872 PhoU domain; Region: PhoU; pfam01895 637910019873 HMMPfam hit to PF01895, PhoU, score 3.3e-31 637910019874 HMMPfam hit to PF01895, PhoU, score 5.8e-31 637910019875 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 637910019876 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910019877 active site 637910019878 motif I; other site 637910019879 motif II; other site 637910019880 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.6e-23 637910019881 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 637910019882 HMMPfam hit to PF00860, Xanthine/uracil/vitamin C permease, score 1.5e-28 637910019883 13 transmembrane helices predicted for ROD40191 by TMHMM2.0 at aa 20-42, 47-69, 71-93, 103-122, 129-148, 163-185, 192-209, 240-262, 282-304, 314-336, 343-361, 376-398 and 411-429 637910019884 PS00267 Tachykinin family signature. 637910019885 Predicted flavoprotein [General function prediction only]; Region: COG0431 637910019886 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 637910019887 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 1.3e-63 637910019888 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 637910019889 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 637910019890 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 637910019891 trmE is a tRNA modification GTPase; Region: trmE; cd04164 637910019892 G1 box; other site 637910019893 GTP/Mg2+ binding site [chemical binding]; other site 637910019894 Switch I region; other site 637910019895 G2 box; other site 637910019896 Switch II region; other site 637910019897 G3 box; other site 637910019898 G4 box; other site 637910019899 G5 box; other site 637910019900 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 637910019901 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 2.4e-42 637910019902 PS00017 ATP/GTP-binding site motif A (P-loop). 637910019903 membrane protein insertase; Provisional; Region: PRK01318 637910019904 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 637910019905 HMMPfam hit to PF02096, 60 kDa inner membrane insertion protein, score 4.1e-124 637910019906 5 transmembrane helices predicted for ROD40241 by TMHMM2.0 at aa 7-24, 346-368, 418-440, 460-477 and 497-519 637910019907 ribonuclease P; Reviewed; Region: rnpA; PRK01732 637910019908 HMMPfam hit to PF00825, Bacterial ribonuclease P protein, score 3.6e-60 637910019909 PS00648 Bacterial ribonuclease P protein component signature. 637910019910 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 637910019911 HMMPfam hit to PF00468, Ribosomal protein L34, score 7e-22 637910019912 PS00784 Ribosomal protein L34 signature. 637910019913 DnaA N-terminal domain; Region: DnaA_N; pfam11638 637910019914 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 637910019915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910019916 Walker A motif; other site 637910019917 ATP binding site [chemical binding]; other site 637910019918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 637910019919 Walker B motif; other site 637910019920 arginine finger; other site 637910019921 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 637910019922 DnaA box-binding interface [nucleotide binding]; other site 637910019923 HMMPfam hit to PF00308, Chromosomal replication initiator, DnaA, score 2.8e-152 637910019924 PS00017 ATP/GTP-binding site motif A (P-loop). 637910019925 HMMPfam hit to PF08299, Chromosomal replication initiator, DnaA C-terminal, score 2.1e-48 637910019926 PS01008 DnaA protein signature. 637910019927 DNA polymerase III subunit beta; Validated; Region: PRK05643 637910019928 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 637910019929 putative DNA binding surface [nucleotide binding]; other site 637910019930 dimer interface [polypeptide binding]; other site 637910019931 beta-clamp/clamp loader binding surface; other site 637910019932 beta-clamp/translesion DNA polymerase binding surface; other site 637910019933 HMMPfam hit to PF00712, DNA polymerase III, subunit beta, score 1.3e-68 637910019934 HMMPfam hit to PF02767, DNA polymerase III, subunit beta, score 3.5e-70 637910019935 HMMPfam hit to PF02768, DNA polymerase III, subunit beta, score 8.3e-63 637910019936 recF protein; Region: recf; TIGR00611 637910019937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910019938 Walker A/P-loop; other site 637910019939 ATP binding site [chemical binding]; other site 637910019940 Q-loop/lid; other site 637910019941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910019942 ABC transporter signature motif; other site 637910019943 Walker B; other site 637910019944 D-loop; other site 637910019945 H-loop/switch region; other site 637910019946 HMMPfam hit to PF02463, SMC protein, N-terminal, score 1.7e-58 637910019947 PS00017 ATP/GTP-binding site motif A (P-loop). 637910019948 PS00617 RecF protein signature 1. 637910019949 PS00618 RecF protein signature 2. 637910019950 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 637910019951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910019952 Mg2+ binding site [ion binding]; other site 637910019953 G-X-G motif; other site 637910019954 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 637910019955 anchoring element; other site 637910019956 dimer interface [polypeptide binding]; other site 637910019957 ATP binding site [chemical binding]; other site 637910019958 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 637910019959 active site 637910019960 putative metal-binding site [ion binding]; other site 637910019961 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 637910019962 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.6e-33 637910019963 HMMPfam hit to PF00204, DNA topoisomerase, type IIA, subunit B, region 2, score 6.8e-97 637910019964 HMMPfam hit to PF01751, TOPRIM, score 1.1e-05 637910019965 PS00177 DNA topoisomerase II signature. 637910019966 HMMPfam hit to PF00986, DNA topoisomerase, type IIA, subunit B, C-terminal, score 5e-47 637910019967 sugar phosphate phosphatase; Provisional; Region: PRK10513 637910019968 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910019969 active site 637910019970 motif I; other site 637910019971 motif II; other site 637910019972 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910019973 PS01228 Hypothetical cof family signature 1. 637910019974 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 2.3e-91 637910019975 PS01229 Hypothetical cof family signature 2. 637910019976 Transcriptional regulators [Transcription]; Region: FadR; COG2186 637910019977 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910019978 DNA-binding site [nucleotide binding]; DNA binding site 637910019979 FCD domain; Region: FCD; pfam07729 637910019980 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 8.6e-15 637910019981 PS00043 Bacterial regulatory proteins, gntR family signature. 637910019982 HMMPfam hit to PF07729, GntR, C-terminal, score 2.7e-35 637910019983 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 637910019984 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 637910019985 HMMPfam hit to PF05035, 2-keto-3-deoxy-galactonokinase, score 1.2e-178 637910019986 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 637910019987 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 637910019988 active site 637910019989 intersubunit interface [polypeptide binding]; other site 637910019990 catalytic residue [active] 637910019991 HMMPfam hit to PF01081, KDPG and KHG aldolase, score 2.3e-11 637910019992 PS00606 beta-ketoacyl synthases active site. 637910019993 galactonate dehydratase; Provisional; Region: PRK14017 637910019994 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 637910019995 putative active site pocket [active] 637910019996 putative metal binding site [ion binding]; other site 637910019997 HMMPfam hit to PF02746, Mandelate racemase/muconate lactonizing enzyme, N-terminal, score 3.5e-56 637910019998 PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 637910019999 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 7.4e-23 637910020000 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 637910020001 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910020003 D-galactonate transporter; Region: 2A0114; TIGR00893 637910020004 putative substrate translocation pore; other site 637910020005 10 transmembrane helices predicted for ROD40341 by TMHMM2.0 at aa 16-38, 53-75, 82-104, 166-188, 242-263, 278-300, 307-329, 339-361, 374-396 and 401-423 637910020006 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.4e-66 637910020007 putative oxidoreductase; Provisional; Region: PRK11445 637910020008 HMMPfam hit to PF01494, Monooxygenase, FAD-binding, score 3.6e-05 637910020009 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 637910020010 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 637910020011 hypothetical protein; Provisional; Region: PRK11616 637910020012 HMMPfam hit to PF07119, Protein of unknown function DUF1375, score 8.1e-42 637910020013 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 637910020014 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 637910020015 putative dimer interface [polypeptide binding]; other site 637910020016 HMMPfam hit to PF00011, Heat shock protein Hsp20, score 7.9e-32 637910020017 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 637910020018 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 637910020019 putative dimer interface [polypeptide binding]; other site 637910020020 HMMPfam hit to PF00011, Heat shock protein Hsp20, score 1.1e-27 637910020021 putative transporter; Validated; Region: PRK03818 637910020022 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 637910020023 TrkA-C domain; Region: TrkA_C; pfam02080 637910020024 TrkA-C domain; Region: TrkA_C; pfam02080 637910020025 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 637910020026 10 transmembrane helices predicted for ROD40411 by TMHMM2.0 at aa 4-21, 28-47, 67-86, 93-115, 156-178, 374-396, 400-419, 431-448, 463-485 and 530-552 637910020027 HMMPfam hit to PF06826, YidE/YbjL duplication, score 1e-61 637910020028 HMMPfam hit to PF02080, TrkA-C, score 2.6e-11 637910020029 HMMPfam hit to PF02080, TrkA-C, score 3.5e-12 637910020030 HMMPfam hit to PF06826, YidE/YbjL duplication, score 9e-66 637910020031 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637910020032 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910020033 DNA-binding site [nucleotide binding]; DNA binding site 637910020034 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 637910020035 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 3.5e-30 637910020036 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 6.7e-26 637910020037 PS00043 Bacterial regulatory proteins, gntR family signature. 637910020038 Predicted helix-turn-helix motif with score 1273.000, SD 3.52 at aa 26-47, sequence PGEKKLAEEFAVSRMTIRKAID 637910020039 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637910020040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910020041 DNA-binding site [nucleotide binding]; DNA binding site 637910020042 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 637910020043 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 2.2e-33 637910020044 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 1.4e-24 637910020045 PS00043 Bacterial regulatory proteins, gntR family signature. 637910020046 Predicted helix-turn-helix motif with score 1103.000, SD 2.94 at aa 26-47, sequence PGENRLASEFGVSRMTVRKAID 637910020047 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 637910020048 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 637910020049 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 637910020050 active site turn [active] 637910020051 phosphorylation site [posttranslational modification] 637910020052 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.3e-69 637910020053 11 transmembrane helices predicted for ROD40441 by TMHMM2.0 at aa 13-35, 61-83, 90-112, 127-149, 162-184, 199-221, 233-255, 278-300, 307-324, 339-361 and 382-404 637910020054 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 6.6e-12 637910020055 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 637910020056 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 637910020057 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 637910020058 NAD binding site [chemical binding]; other site 637910020059 sugar binding site [chemical binding]; other site 637910020060 divalent metal binding site [ion binding]; other site 637910020061 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 637910020062 dimer interface [polypeptide binding]; other site 637910020063 HMMPfam hit to PF02056, Glycoside hydrolase, family 4, score 5.7e-199 637910020064 1 transmembrane helix predicted for ROD40451 by TMHMM2.0 at aa 5-27 637910020065 PS01324 Glycosyl hydrolases family 4 signature. 637910020066 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910020067 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637910020068 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910020069 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 3.4e-09 637910020070 PS00041 Bacterial regulatory proteins, araC family signature. 637910020071 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 3.1e-08 637910020072 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020073 putative transporter; Provisional; Region: PRK10484 637910020074 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 637910020075 Na binding site [ion binding]; other site 637910020076 15 transmembrane helices predicted for ROD40471 by TMHMM2.0 at aa 5-24, 36-58, 73-95, 123-145, 160-182, 191-213, 242-261, 282-304, 327-349, 381-399, 409-428, 435-454, 459-481, 506-528 and 532-551 637910020077 HMMPfam hit to PF00474, Na+/solute symporter, score 3.3e-39 637910020078 PS00456 Sodium:solute symporter family signature 1. 637910020079 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 637910020080 Sulfatase; Region: Sulfatase; pfam00884 637910020081 HMMPfam hit to PF00884, Sulphatase, score 7.6e-79 637910020082 PS00523 Sulfatases signature 1. 637910020083 PS00149 Sulfatases signature 2. 637910020084 3 transmembrane helices predicted for ROD40491 by TMHMM2.0 at aa 12-34, 78-97 and 118-140 637910020085 Predicted membrane protein [Function unknown]; Region: COG2149 637910020086 HMMPfam hit to PF02656, Protein of unknown function DUF202, score 3e-67 637910020087 3 transmembrane helices predicted for ROD40501 by TMHMM2.0 at aa 21-40, 50-72 and 92-114 637910020088 Domain of unknown function (DUF202); Region: DUF202; pfam02656 637910020089 3 transmembrane helices predicted for ROD40511 by TMHMM2.0 at aa 21-38, 48-70 and 91-113 637910020090 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 637910020091 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910020092 FeS/SAM binding site; other site 637910020093 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 637910020094 HMMPfam hit to PF04055, Radical SAM, score 5e-18 637910020095 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 637910020096 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 637910020097 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637910020098 catalytic residue [active] 637910020099 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 8.9e-55 637910020100 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 637910020101 permease DsdX; Provisional; Region: PRK09921 637910020102 gluconate transporter; Region: gntP; TIGR00791 637910020103 HMMPfam hit to PF02447, Gluconate transporter score 3.1e-247 637910020104 12 transmembrane helices predicted for ROD40541 by TMHMM2.0 at aa 4-23, 30-49, 64-86, 106-128, 143-165, 178-197, 226-248, 261-283, 303-322, 343-365, 385-407 and 420-442 637910020105 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020106 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020107 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 637910020108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910020109 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 637910020110 dimerization interface [polypeptide binding]; other site 637910020111 substrate binding pocket [chemical binding]; other site 637910020112 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.4e-19 637910020113 Predicted helix-turn-helix motif with score 1469.000, SD 4.19 at aa 30-51, sequence QSFAMAAEELSLTPGAISHRIN 637910020114 PS00044 Bacterial regulatory proteins, lysR family signature. 637910020115 HMMPfam hit to PF03466, LysR, substrate-binding, score 4.3e-30 637910020116 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 637910020117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910020118 putative substrate translocation pore; other site 637910020119 12 transmembrane helices predicted for ROD40561 by TMHMM2.0 at aa 7-29, 44-66, 75-94, 98-120, 133-155, 165-182, 203-225, 240-262, 275-297, 301-323, 330-352 and 362-384 637910020120 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 2.4e-44 637910020121 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020122 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 637910020123 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 637910020124 10 transmembrane helices predicted for ROD40571 by TMHMM2.0 at aa 4-23, 30-52, 57-76, 89-108, 112-134, 141-158, 168-190, 207-226, 230-252 and 257-276 637910020125 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 1.2e-06 637910020126 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 4.1e-05 637910020127 1 transmembrane helix predicted for ROD40581 by TMHMM2.0 at aa 6-28 637910020128 HMMPfam hit to PF08049, IlvB leader peptide, score 1.1e-11 637910020129 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 637910020130 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 637910020131 PYR/PP interface [polypeptide binding]; other site 637910020132 dimer interface [polypeptide binding]; other site 637910020133 TPP binding site [chemical binding]; other site 637910020134 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 637910020135 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 637910020136 TPP-binding site [chemical binding]; other site 637910020137 dimer interface [polypeptide binding]; other site 637910020138 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-terminal TPP binding region, score 4.4e-108 637910020139 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central region, score 3.9e-66 637910020140 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020141 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-terminal TPP-binding, score 8.6e-68 637910020142 PS00187 Thiamine pyrophosphate enzymes signature. 637910020143 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 637910020144 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 637910020145 putative valine binding site [chemical binding]; other site 637910020146 dimer interface [polypeptide binding]; other site 637910020147 HMMPfam hit to PF01842, Amino acid-binding ACT, score 1.1e-09 637910020148 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 637910020149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910020150 active site 637910020151 phosphorylation site [posttranslational modification] 637910020152 intermolecular recognition site; other site 637910020153 dimerization interface [polypeptide binding]; other site 637910020154 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910020155 DNA binding residues [nucleotide binding] 637910020156 dimerization interface [polypeptide binding]; other site 637910020157 HMMPfam hit to PF00072, Response regulator receiver, score 7.3e-39 637910020158 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020159 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 2.9e-29 637910020160 PS00622 Bacterial regulatory proteins, luxR family signature. 637910020161 Predicted helix-turn-helix motif with score 1034.000, SD 2.71 at aa 153-174, sequence MAVKEIAAVLGLSPKTVHVHRA 637910020162 sensory histidine kinase UhpB; Provisional; Region: PRK11644 637910020163 MASE1; Region: MASE1; pfam05231 637910020164 Histidine kinase; Region: HisKA_3; pfam07730 637910020165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910020166 ATP binding site [chemical binding]; other site 637910020167 Mg2+ binding site [ion binding]; other site 637910020168 G-X-G motif; other site 637910020169 HMMPfam hit to PF05231, MASE1, score 1.4e-68 637910020170 7 transmembrane helices predicted for ROD40631 by TMHMM2.0 at aa 11-33, 78-100, 112-130, 140-162, 186-205, 220-242 and 255-274 637910020171 HMMPfam hit to PF07730, Histidine kinase, dimerisation and phosphoacceptor region, score 5.7e-17 637910020172 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.1e-20 637910020173 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020174 regulatory protein UhpC; Provisional; Region: PRK11663 637910020175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910020176 putative substrate translocation pore; other site 637910020177 12 transmembrane helices predicted for ROD40641 by TMHMM2.0 at aa 26-45, 67-89, 94-116, 121-143, 155-177, 181-203, 245-267, 287-309, 322-344, 348-370, 377-399 and 409-431 637910020178 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 4.8e-58 637910020179 PS00942 glpT family of transporters signature. 637910020180 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 637910020181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910020182 putative substrate translocation pore; other site 637910020183 12 transmembrane helices predicted for ROD40651 by TMHMM2.0 at aa 28-46, 66-88, 97-116, 126-148, 160-182, 192-214, 254-276, 296-318, 325-347, 357-379, 392-414 and 424-446 637910020184 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1e-31 637910020185 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020186 PS00942 glpT family of transporters signature. 637910020187 pseudogene, fragmented by two frameshift mutations and ISCro1 insertion; Similar to ROD45781 637910020188 HMMPfam hit to PF05593, YD repeat, score 3.6 637910020189 HMMPfam hit to PF05593, YD repeat, score 0.027 637910020190 HMMPfam hit to PF05593, YD repeat, score 0.0037 637910020191 HMMPfam hit to PF05593, YD repeat, score 0.00044 637910020192 HMMPfam hit to PF05593, YD repeat, score 0.0029 637910020193 HMMPfam hit to PF05593, YD repeat, score 0.00021 637910020194 HMMPfam hit to PF05593, YD repeat, score 9.3e-07 637910020195 HMMPfam hit to PF05593, YD repeat, score 0.19 637910020196 HMMPfam hit to PF05593, YD repeat, score 0.00029 637910020197 HMMPfam hit to PF05593, YD repeat, score 0.0065 637910020198 HMMPfam hit to PF05593, YD repeat, score 0.035 637910020199 HMMPfam hit to PF03527, RHS protein, score 7.8e-23 637910020200 HMMPfam hit to PF05593, YD repeat, score 2.1 637910020201 Transposase; Region: HTH_Tnp_1; pfam01527 637910020202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910020203 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910020204 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910020205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910020206 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910020207 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910020208 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910020209 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910020210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910020211 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910020212 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910020213 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910020214 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910020215 4 transmembrane helices predicted for ROD40731 by TMHMM2.0 at aa 21-43, 53-75, 80-102 and 106-128 637910020216 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020217 pseudogene, N-terminus missing, fragment 637910020218 pseudogene, N-terminus missing, C-terminal part truncated by frameshift mutation and premature stop codon 637910020219 HMMPfam hit to PF00529, Secretion protein HlyD, score 2.2e-05 637910020220 CR_GI11 637910020221 pseudogene, N- and C-termini missing, truncated by frameshift mutation 637910020222 pseudogene, N-terminus missing, fragment 637910020223 pseudogene, truncated by frameshift mutation 637910020224 HMMPfam hit to PF02368, Bacterial Ig-like, group 2, score 0.27 637910020225 HMMPfam hit to PF02369, Bacterial Ig-like, group 1, score 1.1e-06 637910020226 HMMPfam hit to PF02369, Bacterial Ig-like, group 1, score 8.5e-10 637910020227 HMMPfam hit to PF02369, Bacterial Ig-like, group 1, score 0.0016 637910020228 HMMPfam hit to PF02369, Bacterial Ig-like, group 1, score 0.0084 637910020229 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 3.1e-07 637910020230 pseudogene, truncated by two frameshift mutations 637910020231 HMMPfam hit to PF04754, Transposase (), YhgA-like, score 2e-206 637910020232 pseudogene, fragmented by three premature stop codons and a frameshift mutation 637910020233 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 637910020234 HMMPfam hit to PF03278, IpaB/EvcA, score 6.7e-18 637910020235 1 transmembrane helix predicted for ROD40921 by TMHMM2.0 at aa 24-41 637910020236 pseudogene, N- and C-termini missing, truncated by frameshift 637910020237 HMMPfam hit to PF00665, Integrase, catalytic core, score 3e-20 637910020238 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 637910020239 HMMPfam hit to PF06416, Protein of unknown function DUF1076, score 9.7e-94 637910020240 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 637910020241 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 637910020242 HMMPfam hit to PF03278, IpaB/EvcA, score 1.9e-65 637910020243 pseudogene, truncated by premature stop codon 637910020244 HMMPfam hit to PF01609, Transposase, IS4-like, score 2.7e-09 637910020245 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 637910020246 Catalytic site [active] 637910020247 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, C-terminal, score 4.5e-09 637910020248 1 transmembrane helix predicted for ROD41021 by TMHMM2.0 at aa 38-60 637910020249 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 637910020250 HlyD family secretion protein; Region: HlyD_3; pfam13437 637910020251 1 transmembrane helix predicted for ROD41041 by TMHMM2.0 at aa 26-48 637910020252 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 637910020253 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 637910020254 putative active site [active] 637910020255 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637910020256 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 637910020257 Walker A/P-loop; other site 637910020258 ATP binding site [chemical binding]; other site 637910020259 Q-loop/lid; other site 637910020260 ABC transporter signature motif; other site 637910020261 Walker B; other site 637910020262 D-loop; other site 637910020263 H-loop/switch region; other site 637910020264 HMMPfam hit to PF03412, Peptidase C39, bacteriocin processing, score 1.7e-25 637910020265 5 transmembrane helices predicted for ROD41051 by TMHMM2.0 at aa 178-200, 215-234, 294-313, 318-337 and 417-439 637910020266 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 3.8e-25 637910020267 HMMPfam hit to PF00005, ABC transporter related, score 7.8e-37 637910020268 PS00017 ATP/GTP-binding site motif A (P-loop). 637910020269 PS00211 ABC transporters family signature. 637910020270 pseudogene, N- and C-termini missing, fragment 637910020271 HMMPfam hit to PF05857, TraX, score 5.9e-51 637910020272 TraX protein; Region: TraX; cl05434 637910020273 1 transmembrane helix predicted for ROD41071 by TMHMM2.0 at aa 57-79 637910020274 pseudogene, fragmented by two frameshift mutations and a premature stop codon 637910020275 HMMPfam hit to PF05286, Fertility inhibition, score 1.8e-94 637910020276 1 transmembrane helix predicted for ROD41101 by TMHMM2.0 at aa 79-101 637910020277 HMMPfam hit to PF06711, Protein of unknown function DUF1198, score 1.1e-77 637910020278 pseudogene, N-terminal 30 aa missing, fragment 637910020279 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 637910020280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910020281 putative substrate translocation pore; other site 637910020282 Predicted helix-turn-helix motif with score 1091.000, SD 2.90 at aa 3-24, sequence ECIEEKARAEGVARPNWSAVFA 637910020283 12 transmembrane helices predicted for ROD41131 by TMHMM2.0 at aa 20-42, 57-79, 86-105, 110-132, 145-167, 177-196, 217-239, 254-276, 283-302, 306-328, 341-363 and 367-389 637910020284 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 4.5e-41 637910020285 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020286 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 637910020287 HMMPfam hit to PF02264, Porin, LamB type, score 5.7e-09 637910020288 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 637910020289 methionine cluster; other site 637910020290 active site 637910020291 phosphorylation site [posttranslational modification] 637910020292 metal binding site [ion binding]; metal-binding site 637910020293 HMMPfam hit to PF02255, Phosphotransferase system, lactose/cellobiose-specific IIA subunit, score 1.5e-39 637910020294 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 637910020295 beta-galactosidase; Region: BGL; TIGR03356 637910020296 HMMPfam hit to PF00232, Glycoside hydrolase, family 1, score 1.8e-132 637910020297 PS00572 Glycosyl hydrolases family 1 active site. 637910020298 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 637910020299 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 637910020300 8 transmembrane helices predicted for ROD41171 by TMHMM2.0 at aa 35-57, 82-104, 111-128, 138-160, 240-262, 289-311, 332-354 and 392-414 637910020301 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 5.7e-71 637910020302 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 637910020303 active site 637910020304 P-loop; other site 637910020305 phosphorylation site [posttranslational modification] 637910020306 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 1.1e-28 637910020307 catabolite control protein A; Region: ccpA; TIGR01481 637910020308 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910020309 DNA binding site [nucleotide binding] 637910020310 domain linker motif; other site 637910020311 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 637910020312 ligand binding site [chemical binding]; other site 637910020313 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 4.6e-10 637910020314 Predicted helix-turn-helix motif with score 1759.000, SD 5.18 at aa 2-23, sequence STINDVSRLAGVSKATVSRVLS 637910020315 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 637910020316 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 6.7e-12 637910020317 EamA-like transporter family; Region: EamA; pfam00892 637910020318 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 637910020319 EamA-like transporter family; Region: EamA; pfam00892 637910020320 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 7e-25 637910020321 10 transmembrane helices predicted for ROD41211 by TMHMM2.0 at aa 7-29, 39-59, 72-94, 99-118, 125-147, 157-176, 183-205, 215-237, 250-272 and 276-290 637910020322 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 3.7e-15 637910020323 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 637910020324 2 transmembrane helices predicted for ROD41231 by TMHMM2.0 at aa 7-26 and 150-172 637910020325 Fimbrial protein; Region: Fimbrial; pfam00419 637910020326 Fimbrial protein; Region: Fimbrial; pfam00419 637910020327 Fimbrial protein; Region: Fimbrial; pfam00419 637910020328 1 transmembrane helix predicted for ROD41261 by TMHMM2.0 at aa 5-22 637910020329 fimbrial chaperone protein PefD; Provisional; Region: PRK15211 637910020330 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637910020331 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637910020332 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 1.3e-09 637910020333 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 3.2e-38 637910020334 1 transmembrane helix predicted for ROD41271 by TMHMM2.0 at aa 10-32 637910020335 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 637910020336 PapC N-terminal domain; Region: PapC_N; pfam13954 637910020337 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637910020338 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 9.3e-172 637910020339 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 637910020340 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 637910020341 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 0.00093 637910020342 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 637910020343 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 637910020344 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637910020345 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637910020346 1 transmembrane helix predicted for ROD41301 by TMHMM2.0 at aa 36-53 637910020347 HMMPfam hit to PF02395, Peptidase S6, IgA endopeptidase, score 2.1e-267 637910020348 HMMPfam hit to PF03797, Autotransporter beta-domain, score 2.4e-34 637910020349 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637910020350 DNA binding residues [nucleotide binding] 637910020351 Predicted helix-turn-helix motif with score 1316.000, SD 3.67 at aa 118-139, sequence FRIKAIAAILQLRVSQVYYRIK 637910020352 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637910020353 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910020354 Predicted helix-turn-helix motif with score 1408.000, SD 3.98 at aa 188-209, sequence WRLVDLANILHMSEVSIRKKLE 637910020355 PS00041 Bacterial regulatory proteins, araC family signature. 637910020356 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 5.7e-13 637910020357 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637910020358 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910020359 DNA binding residues [nucleotide binding] 637910020360 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 1.4e-12 637910020361 Predicted helix-turn-helix motif with score 1531.000, SD 4.40 at aa 111-132, sequence ISQKHIATKLHISEKTVSTHKL 637910020362 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 637910020363 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637910020364 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910020365 DNA binding residues [nucleotide binding] 637910020366 dimerization interface [polypeptide binding]; other site 637910020367 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 8.8e-10 637910020368 PS00622 Bacterial regulatory proteins, luxR family signature. 637910020369 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 637910020370 DNA binding site [nucleotide binding] 637910020371 1 transmembrane helix predicted for ROD41371 by TMHMM2.0 at aa 187-205 637910020372 Flp/Fap pilin component; Region: Flp_Fap; cl01585 637910020373 HMMPfam hit to PF04964, Flp/Fap pilin component, score 1.7e-11 637910020374 1 transmembrane helix predicted for ROD41381 by TMHMM2.0 at aa 15-37 637910020375 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 637910020376 1 transmembrane helix predicted for ROD41391 by TMHMM2.0 at aa 7-26 637910020377 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 637910020378 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 637910020379 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 637910020380 1 transmembrane helix predicted for ROD41401 by TMHMM2.0 at aa 12-34 637910020381 HMMPfam hit to PF00263, Bacterial type II and III secretion system protein, score 2.8e-55 637910020382 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 637910020383 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 637910020384 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 637910020385 ATP binding site [chemical binding]; other site 637910020386 Walker A motif; other site 637910020387 hexamer interface [polypeptide binding]; other site 637910020388 Walker B motif; other site 637910020389 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 7.3e-103 637910020390 PS00227 Tubulin subunits alpha, beta, and gamma signature. 637910020391 PS00017 ATP/GTP-binding site motif A (P-loop). 637910020392 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 637910020393 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 637910020394 5 transmembrane helices predicted for ROD41431 by TMHMM2.0 at aa 4-21, 73-90, 94-116, 242-261 and 276-298 637910020395 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 6.2e-09 637910020396 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 637910020397 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 637910020398 4 transmembrane helices predicted for ROD41441 by TMHMM2.0 at aa 4-21, 74-91, 96-118 and 257-279 637910020399 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020400 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 7.5e-15 637910020401 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 637910020402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637910020403 binding surface 637910020404 TPR motif; other site 637910020405 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020406 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 637910020407 G2 box; other site 637910020408 Switch I region; other site 637910020409 G3 box; other site 637910020410 Switch II region; other site 637910020411 GTP/Mg2+ binding site [chemical binding]; other site 637910020412 G4 box; other site 637910020413 G5 box; other site 637910020414 HMMPfam hit to PF03029, Protein of unknown function, ATP binding, score 1.7e-09 637910020415 PS00017 ATP/GTP-binding site motif A (P-loop). 637910020416 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 637910020417 HMMPfam hit to PF03259, Roadblock/LC7, score 0.0047 637910020418 4 transmembrane helices predicted for ROD41521 by TMHMM2.0 at aa 4-26, 38-71, 99-121 and 128-147 637910020419 HMMPfam hit to PF01478, Peptidase A24A, prepilin type IV, score 1.3e-11 637910020420 HMMPfam hit to PF07811, TadE-like, score 5.2e-12 637910020421 1 transmembrane helix predicted for ROD41531 by TMHMM2.0 at aa 25-47 637910020422 TadE-like protein; Region: TadE; pfam07811 637910020423 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 637910020424 1 transmembrane helix predicted for ROD41541 by TMHMM2.0 at aa 31-53 637910020425 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 637910020426 TadE-like protein; Region: TadE; pfam07811 637910020427 von Willebrand factor type A domain; Region: VWA_2; pfam13519 637910020428 1 transmembrane helix predicted for ROD41551 by TMHMM2.0 at aa 21-43 637910020429 PS00017 ATP/GTP-binding site motif A (P-loop). 637910020430 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 637910020431 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 637910020432 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 637910020433 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 637910020434 pseudogene, N-terminus missing, fragment 637910020435 HMMPfam hit to PF01464, Lytic transglycosylase-like, catalytic, score 9.5e-05 637910020436 putative transporter; Provisional; Region: PRK11462 637910020437 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 637910020438 11 transmembrane helices predicted for ROD41591 by TMHMM2.0 at aa 35-57, 82-99, 109-131, 152-174, 179-201, 232-254, 264-286, 293-315, 320-342, 363-385 and 400-422 637910020439 PS00872 Sodium:galactoside symporter family signature. 637910020440 putative alpha-glucosidase; Provisional; Region: PRK10658 637910020441 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 637910020442 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 637910020443 active site 637910020444 homotrimer interface [polypeptide binding]; other site 637910020445 catalytic site [active] 637910020446 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 637910020447 HMMPfam hit to PF01055, Glycoside hydrolase, family 31, score 8.5e-182 637910020448 AsmA family; Region: AsmA; pfam05170 637910020449 HMMPfam hit to PF05170, AsmA, score 1.2e-216 637910020450 1 transmembrane helix predicted for ROD41611 by TMHMM2.0 at aa 7-26 637910020451 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 637910020452 11 transmembrane helices predicted for ROD41621 by TMHMM2.0 at aa 43-65, 90-112, 127-149, 156-178, 193-212, 219-241, 261-283, 346-368, 378-400, 407-429 and 439-458 637910020453 HMMPfam hit to PF00860, Xanthine/uracil/vitamin C permease, score 6.6e-159 637910020454 PS01116 Xanthine/uracil permeases family signature. 637910020455 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 637910020456 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020457 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020458 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 637910020459 HMMPfam hit to PF03616, Sodium/glutamate symporter, score 1.9e-253 637910020460 9 transmembrane helices predicted for ROD41631 by TMHMM2.0 at aa 70-87, 94-116, 157-179, 213-235, 245-267, 274-292, 302-324, 337-359 and 374-396 637910020461 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 637910020462 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 637910020463 generic binding surface II; other site 637910020464 ssDNA binding site; other site 637910020465 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637910020466 ATP binding site [chemical binding]; other site 637910020467 putative Mg++ binding site [ion binding]; other site 637910020468 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637910020469 nucleotide binding region [chemical binding]; other site 637910020470 ATP-binding site [chemical binding]; other site 637910020471 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 9.7e-25 637910020472 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 1.2e-33 637910020473 PS00017 ATP/GTP-binding site motif A (P-loop). 637910020474 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 6.2e-11 637910020475 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 637910020476 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 637910020477 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 637910020478 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase, SpoU, score 2.4e-53 637910020479 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 637910020480 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 637910020481 Zn2+ binding site [ion binding]; other site 637910020482 Mg2+ binding site [ion binding]; other site 637910020483 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 637910020484 synthetase active site [active] 637910020485 NTP binding site [chemical binding]; other site 637910020486 metal binding site [ion binding]; metal-binding site 637910020487 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 637910020488 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 637910020489 HMMPfam hit to PF02824, TGS, score 2.4e-28 637910020490 HMMPfam hit to PF04607, RelA/SpoT, score 5.2e-45 637910020491 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 6.5e-20 637910020492 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020493 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 637910020494 HMMPfam hit to PF01192, RNA polymerase Rpb6, score 3.9e-23 637910020495 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 637910020496 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 637910020497 catalytic site [active] 637910020498 G-X2-G-X-G-K; other site 637910020499 HMMPfam hit to PF00625, Guanylate kinase, score 3e-66 637910020500 PS00856 Guanylate kinase signature. 637910020501 PS00017 ATP/GTP-binding site motif A (P-loop). 637910020502 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 637910020503 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 637910020504 nucleotide binding pocket [chemical binding]; other site 637910020505 K-X-D-G motif; other site 637910020506 catalytic site [active] 637910020507 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 637910020508 HMMPfam hit to PF01653, NAD-dependent DNA ligase, adenylation, score 1.8e-69 637910020509 PS01055 NAD-dependent DNA ligase signature 1. 637910020510 HMMPfam hit to PF03120, NAD-dependent DNA ligase, OB-fold, score 3.9e-27 637910020511 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 637910020512 pseudogene, truncated by premature stop codon 637910020513 HMMPfam hit to PF03458, Protein of unknown function UPF0126, score 2.9e-36 637910020514 HMMPfam hit to PF03458, Protein of unknown function UPF0126, score 1e-36 637910020515 hypothetical protein; Provisional; Region: PRK11820 637910020516 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 637910020517 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 637910020518 HMMPfam hit to PF08340, Region of unknown function DUF1732, score 1.8e-56 637910020519 HMMPfam hit to PF03755, YicC-like, N-terminal, score 1.1e-86 637910020520 ribonuclease PH; Reviewed; Region: rph; PRK00173 637910020521 Ribonuclease PH; Region: RNase_PH_bact; cd11362 637910020522 hexamer interface [polypeptide binding]; other site 637910020523 active site 637910020524 HMMPfam hit to PF01138, Exoribonuclease, phosphorolytic domain 1, score 8.8e-56 637910020525 PS01277 Ribonuclease PH signature. 637910020526 HMMPfam hit to PF03725, Exoribonuclease, phosphorolytic domain 2, score 1.4e-23 637910020527 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637910020528 active site 637910020529 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 5.4e-33 637910020530 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 637910020531 division inhibitor protein; Provisional; Region: slmA; PRK09480 637910020532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637910020533 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 2e-11 637910020534 PS01081 Bacterial regulatory proteins, tetR family signature. 637910020535 Predicted helix-turn-helix motif with score 1937.000, SD 5.78 at aa 32-53, sequence ITTAKLAASVGVSEAALYRHFP 637910020536 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 637910020537 trimer interface [polypeptide binding]; other site 637910020538 active site 637910020539 HMMPfam hit to PF00692, DeoxyUTP pyrophosphatase, score 1.3e-55 637910020540 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 637910020541 Flavoprotein; Region: Flavoprotein; pfam02441 637910020542 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 637910020543 HMMPfam hit to PF04127, DNA/pantothenate metabolism flavoprotein, C-terminal, score 3.3e-43 637910020544 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020545 HMMPfam hit to PF02441, Flavoprotein, score 1.1e-47 637910020546 hypothetical protein; Reviewed; Region: PRK00024 637910020547 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 637910020548 MPN+ (JAMM) motif; other site 637910020549 Zinc-binding site [ion binding]; other site 637910020550 HMMPfam hit to PF04002, DNA repair protein RadC, score 6.5e-78 637910020551 PS01302 DNA repair protein radC family signature. 637910020552 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 637910020553 HMMPfam hit to PF00830, Ribosomal protein L28, score 7e-36 637910020554 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 637910020555 HMMPfam hit to PF00471, Ribosomal protein L33, score 1.5e-24 637910020556 PS00582 Ribosomal protein L33 signature. 637910020557 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 637910020558 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910020559 HMMPfam hit to PF01609, Transposase, IS4-like, score 2.2e-25 637910020560 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 637910020561 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 637910020562 DNA binding site [nucleotide binding] 637910020563 catalytic residue [active] 637910020564 H2TH interface [polypeptide binding]; other site 637910020565 putative catalytic residues [active] 637910020566 turnover-facilitating residue; other site 637910020567 intercalation triad [nucleotide binding]; other site 637910020568 8OG recognition residue [nucleotide binding]; other site 637910020569 putative reading head residues; other site 637910020570 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 637910020571 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 637910020572 HMMPfam hit to PF01149, Formamidopyrimidine-DNA glycosylase, catalytic, score 2.1e-48 637910020573 HMMPfam hit to PF06831, Formamidopyrimidine-DNA glycolase, H2TH DNA binding, score 2e-52 637910020574 HMMPfam hit to PF06827, Formamidopyrimidine-DNA glycolase, C-terminal, score 0.0019 637910020575 PS01242 Formamidopyrimidine-DNA glycosylase signature. 637910020576 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 637910020577 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 637910020578 active site 637910020579 (T/H)XGH motif; other site 637910020580 HMMPfam hit to PF01467, Cytidylyltransferase, score 1.9e-38 637910020581 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 637910020582 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 637910020583 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 637910020584 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 8.5e-08 637910020585 HMMPfam hit to PF04413, Three-deoxy-D-manno-octulosonic-acid transferase, N-terminal, score 9.2e-116 637910020586 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 637910020587 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 637910020588 putative active site [active] 637910020589 HMMPfam hit to PF01075, Glycosyl transferase, family 9, score 1.2e-89 637910020590 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 637910020591 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 637910020592 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 637910020593 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 1e-43 637910020594 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 637910020595 HMMPfam hit to PF06293, Lipopolysaccharide kinase, score 1.1e-90 637910020596 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 637910020597 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 637910020598 putative ADP-binding pocket [chemical binding]; other site 637910020599 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 3.6e-34 637910020600 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 637910020601 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 637910020602 Ligand binding site; other site 637910020603 metal-binding site 637910020604 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 637910020605 HMMPfam hit to PF01501, Glycosyl transferase, family 8, score 3.2e-79 637910020606 PS00017 ATP/GTP-binding site motif A (P-loop). 637910020607 HMMPfam hit to PF08437, Glycosyl transferase, family 8, C-terminal, score 9.5e-28 637910020608 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 637910020609 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 637910020610 Ligand binding site; other site 637910020611 metal-binding site 637910020612 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 637910020613 HMMPfam hit to PF01501, Glycosyl transferase, family 8, score 7.3e-82 637910020614 HMMPfam hit to PF08437, Glycosyl transferase, family 8, C-terminal, score 1.9e-27 637910020615 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10359 637910020616 HMMPfam hit to PF06176, Lipopolysaccharide core biosynthesis, score 9.9e-175 637910020617 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 637910020618 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 637910020619 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 637910020620 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 2.6e-53 637910020621 O-antigen ligase RfaL; Provisional; Region: PRK15487 637910020622 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 637910020623 10 transmembrane helices predicted for ROD41951 by TMHMM2.0 at aa 17-36, 41-58, 65-87, 97-116, 129-151, 166-183, 190-221, 231-248, 326-348 and 363-380 637910020624 HMMPfam hit to PF04932, O-antigen polymerase, score 1.6e-15 637910020625 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 637910020626 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 637910020627 putative active site [active] 637910020628 HMMPfam hit to PF01075, Glycosyl transferase, family 9, score 2.4e-111 637910020629 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 637910020630 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 637910020631 putative active site [active] 637910020632 HMMPfam hit to PF01075, Glycosyl transferase, family 9, score 1.5e-117 637910020633 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 637910020634 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 637910020635 NADP binding site [chemical binding]; other site 637910020636 homopentamer interface [polypeptide binding]; other site 637910020637 substrate binding site [chemical binding]; other site 637910020638 active site 637910020639 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 7.2e-52 637910020640 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 637910020641 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 637910020642 substrate-cofactor binding pocket; other site 637910020643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910020644 catalytic residue [active] 637910020645 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 1.5e-111 637910020646 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 637910020647 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 637910020648 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 637910020649 NAD(P) binding site [chemical binding]; other site 637910020650 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 2.7e-47 637910020651 PS00059 Zinc-containing alcohol dehydrogenases signature. 637910020652 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 1.6e-39 637910020653 putative glycosyl transferase; Provisional; Region: PRK10073 637910020654 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 637910020655 active site 637910020656 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 2.2e-41 637910020657 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 637910020658 putative active site [active] 637910020659 NodB motif; other site 637910020660 HMMPfam hit to PF04748, Protein of unknown function DUF610, YibQ, score 9.9e-96 637910020661 AmiB activator; Provisional; Region: PRK11637 637910020662 Peptidase family M23; Region: Peptidase_M23; pfam01551 637910020663 HMMPfam hit to PF01551, Peptidase M23B, score 3.4e-48 637910020664 1 transmembrane helix predicted for ROD42031 by TMHMM2.0 at aa 7-29 637910020665 phosphoglyceromutase; Provisional; Region: PRK05434 637910020666 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 637910020667 HMMPfam hit to PF01676, Metalloenzyme, score 2.3e-58 637910020668 HMMPfam hit to PF06415, BPG-independent PGAM, N-terminal, score 1.3e-253 637910020669 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 637910020670 active site residue [active] 637910020671 1 transmembrane helix predicted for ROD42051 by TMHMM2.0 at aa 7-29 637910020672 HMMPfam hit to PF00581, Rhodanese-like, score 1.4e-22 637910020673 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 637910020674 GSH binding site [chemical binding]; other site 637910020675 catalytic residues [active] 637910020676 HMMPfam hit to PF00462, Glutaredoxin, score 2.1e-28 637910020677 PS00195 Glutaredoxin active site. 637910020678 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 637910020679 SecA binding site; other site 637910020680 Preprotein binding site; other site 637910020681 HMMPfam hit to PF02556, Bacterial protein export chaperone SecB, score 5.4e-102 637910020682 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 637910020683 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 637910020684 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 637910020685 HMMPfam hit to PF01210, NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal, score 7.9e-82 637910020686 HMMPfam hit to PF07479, NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal, score 4.5e-83 637910020687 PS00957 NAD-dependent glycerol-3-phosphate dehydrogenase signature. 637910020688 serine acetyltransferase; Provisional; Region: cysE; PRK11132 637910020689 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 637910020690 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 637910020691 trimer interface [polypeptide binding]; other site 637910020692 active site 637910020693 substrate binding site [chemical binding]; other site 637910020694 CoA binding site [chemical binding]; other site 637910020695 HMMPfam hit to PF06426, Serine acetyltransferase, N-terminal, score 1.6e-66 637910020696 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.93 637910020697 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 9.9 637910020698 PS00101 Hexapeptide-repeat containing-transferases signature. 637910020699 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 2.2 637910020700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910020701 D-galactonate transporter; Region: 2A0114; TIGR00893 637910020702 putative substrate translocation pore; other site 637910020703 12 transmembrane helices predicted for ROD42101 by TMHMM2.0 at aa 13-35, 50-72, 79-101, 105-127, 140-162, 172-190, 240-262, 277-299, 311-333, 338-360, 372-394 and 404-426 637910020704 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 4e-59 637910020705 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020706 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 637910020707 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 637910020708 active site pocket [active] 637910020709 HMMPfam hit to PF01188, Mandelate racemase/muconate lactonizing enzyme, C-terminal, score 1.4e-39 637910020710 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 637910020711 HMMPfam hit to PF02746, Mandelate racemase/muconate lactonizing enzyme, N-terminal, score 1.3e-08 637910020712 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637910020713 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910020714 DNA binding site [nucleotide binding] 637910020715 domain linker motif; other site 637910020716 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 637910020717 putative dimerization interface [polypeptide binding]; other site 637910020718 putative ligand binding site [chemical binding]; other site 637910020719 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 1.6e-09 637910020720 Predicted helix-turn-helix motif with score 1801.000, SD 5.32 at aa 10-31, sequence PTLEDVARSAGLSSMTVSRVLN 637910020721 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 1.1e-10 637910020722 putative rRNA methylase; Provisional; Region: PRK10358 637910020723 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase, SpoU, score 4.3e-45 637910020724 pseudogene, fragmented by internal deletion and frameshift mutation 637910020725 HMMPfam hit to PF01070, FMN-dependent alpha-hydroxy acid dehydrogenase, score 1.6e-198 637910020726 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 637910020727 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910020728 DNA-binding site [nucleotide binding]; DNA binding site 637910020729 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 637910020730 HMMPfam hit to PF07729, GntR, C-terminal, score 1.2e-40 637910020731 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 4.9e-27 637910020732 PS00043 Bacterial regulatory proteins, gntR family signature. 637910020733 Predicted helix-turn-helix motif with score 1006.000, SD 2.61 at aa 32-53, sequence PAERQLAHQLGVSRNSLREALA 637910020734 L-lactate permease; Provisional; Region: PRK10420 637910020735 glycolate transporter; Provisional; Region: PRK09695 637910020736 13 transmembrane helices predicted for ROD42171 by TMHMM2.0 at aa 13-35, 40-62, 69-91, 128-150, 157-179, 194-213, 299-321, 368-387, 399-421, 431-453, 466-488, 498-515 and 528-550 637910020737 HMMPfam hit to PF02652, L-lactate permease, score 0 637910020738 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020739 hypothetical protein; Provisional; Region: PRK11020 637910020740 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 637910020741 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 637910020742 HMMPfam hit to PF05068, Mannitol repressor, score 7.4e-117 637910020743 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 637910020744 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 637910020745 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 637910020746 HMMPfam hit to PF08125, Mannitol dehydrogenase, C-terminal, score 1.6e-113 637910020747 PS00974 Mannitol dehydrogenases signature. 637910020748 HMMPfam hit to PF01232, Mannitol dehydrogenase rossman, N-terminal, score 7.6e-50 637910020749 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 637910020750 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 637910020751 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 637910020752 active site 637910020753 P-loop; other site 637910020754 phosphorylation site [posttranslational modification] 637910020755 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637910020756 active site 637910020757 phosphorylation site [posttranslational modification] 637910020758 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 4.4e-78 637910020759 PS00372 PTS EIIA domains phosphorylation site signature 2. 637910020760 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 3e-13 637910020761 8 transmembrane helices predicted for ROD42221 by TMHMM2.0 at aa 20-42, 52-74, 87-109, 129-151, 212-234, 244-263, 270-292 and 312-334 637910020762 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 2.2e-28 637910020763 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 637910020764 2 transmembrane helices predicted for ROD42231 by TMHMM2.0 at aa 2-24 and 44-66 637910020765 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 637910020766 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637910020767 HlyD family secretion protein; Region: HlyD_3; pfam13437 637910020768 2 transmembrane helices predicted for ROD42241 by TMHMM2.0 at aa 5-22 and 27-49 637910020769 HMMPfam hit to PF00529, Secretion protein HlyD, score 1.4e-61 637910020770 putative glutathione S-transferase; Provisional; Region: PRK10357 637910020771 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 637910020772 putative C-terminal domain interface [polypeptide binding]; other site 637910020773 putative GSH binding site (G-site) [chemical binding]; other site 637910020774 putative dimer interface [polypeptide binding]; other site 637910020775 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 637910020776 dimer interface [polypeptide binding]; other site 637910020777 N-terminal domain interface [polypeptide binding]; other site 637910020778 putative substrate binding pocket (H-site) [chemical binding]; other site 637910020779 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 1.3e-07 637910020780 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 1.7e-18 637910020781 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020782 selenocysteine synthase; Provisional; Region: PRK04311 637910020783 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 637910020784 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 637910020785 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 637910020786 catalytic residue [active] 637910020787 HMMPfam hit to PF03841, L-seryl-tRNA selenium transferase, score 2e-273 637910020788 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 637910020789 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 637910020790 G1 box; other site 637910020791 putative GEF interaction site [polypeptide binding]; other site 637910020792 GTP/Mg2+ binding site [chemical binding]; other site 637910020793 Switch I region; other site 637910020794 G2 box; other site 637910020795 G3 box; other site 637910020796 Switch II region; other site 637910020797 G4 box; other site 637910020798 G5 box; other site 637910020799 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 637910020800 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 637910020801 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 637910020802 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 637910020803 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 2.2e-41 637910020804 PS00017 ATP/GTP-binding site motif A (P-loop). 637910020805 PS00301 GTP-binding elongation factors signature. 637910020806 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 2.3e-11 637910020807 HMMPfam hit to PF09106, Translation elongation factor SelB, winged helix, type 2, score 2.4e-23 637910020808 HMMPfam hit to PF09107, Translation elongation factor SelB, winged helix, type 3, score 8.3e-26 637910020809 putative alcohol dehydrogenase; Provisional; Region: PRK09860 637910020810 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 637910020811 dimer interface [polypeptide binding]; other site 637910020812 active site 637910020813 metal binding site [ion binding]; metal-binding site 637910020814 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 3.5e-222 637910020815 PS00152 ATP synthase alpha and beta subunits signature. 637910020816 PS00913 Iron-containing alcohol dehydrogenases signature 1. 637910020817 PS00060 Iron-containing alcohol dehydrogenases signature 2. 637910020818 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 637910020819 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637910020820 nucleotide binding site [chemical binding]; other site 637910020821 HMMPfam hit to PF00480, ROK, score 2e-39 637910020822 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 637910020823 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 637910020824 NAD(P) binding site [chemical binding]; other site 637910020825 catalytic residues [active] 637910020826 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 2.5e-216 637910020827 PS00687 Aldehyde dehydrogenases glutamic acid active site. 637910020828 PS00070 Aldehyde dehydrogenases cysteine active site. 637910020829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 637910020830 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 637910020831 HMMPfam hit to PF07944, Protein of unknown function DUF1680, score 1.9e-272 637910020832 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 637910020833 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 637910020834 12 transmembrane helices predicted for ROD42321 by TMHMM2.0 at aa 26-48, 53-75, 96-113, 123-145, 166-184, 199-218, 245-267, 277-299, 312-329, 339-361, 385-407 and 422-444 637910020835 PS00872 Sodium:galactoside symporter family signature. 637910020836 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 637910020837 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 637910020838 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910020839 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 0.00026 637910020840 PS00041 Bacterial regulatory proteins, araC family signature. 637910020841 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 4.6e-07 637910020842 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 637910020843 DNA binding site [nucleotide binding] 637910020844 1 transmembrane helix predicted for ROD42351 by TMHMM2.0 at aa 33-55 637910020845 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 637910020846 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637910020847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910020848 homodimer interface [polypeptide binding]; other site 637910020849 catalytic residue [active] 637910020850 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 1.8e-10 637910020851 alpha-amylase; Reviewed; Region: malS; PRK09505 637910020852 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 637910020853 active site 637910020854 catalytic site [active] 637910020855 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 1.3e-93 637910020856 hypothetical protein; Provisional; Region: PRK10356 637910020857 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 637910020858 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase, score 0.0011 637910020859 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 637910020860 putative dimerization interface [polypeptide binding]; other site 637910020861 Transcriptional regulators [Transcription]; Region: PurR; COG1609 637910020862 putative ligand binding site [chemical binding]; other site 637910020863 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910020864 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637910020865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910020866 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 6.7e-16 637910020867 PS00041 Bacterial regulatory proteins, araC family signature. 637910020868 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2e-10 637910020869 xylose isomerase; Provisional; Region: PRK05474 637910020870 xylose isomerase; Region: xylose_isom_A; TIGR02630 637910020871 HMMPfam hit to PF01261, Xylose isomerase-type TIM barrel, score 2.3e-12 637910020872 PS00173 Xylose isomerase signature 2. 637910020873 PS00172 Xylose isomerase signature 1. 637910020874 xylulokinase; Provisional; Region: PRK15027 637910020875 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 637910020876 N- and C-terminal domain interface [polypeptide binding]; other site 637910020877 active site 637910020878 MgATP binding site [chemical binding]; other site 637910020879 catalytic site [active] 637910020880 metal binding site [ion binding]; metal-binding site 637910020881 xylulose binding site [chemical binding]; other site 637910020882 homodimer interface [polypeptide binding]; other site 637910020883 HMMPfam hit to PF00370, Carbohydrate kinase, FGGY, score 3.2e-125 637910020884 HMMPfam hit to PF02782, Carbohydrate kinase, FGGY, score 6e-107 637910020885 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020886 PS00445 FGGY family of carbohydrate kinases signature 2. 637910020887 hypothetical protein; Provisional; Region: PRK11403 637910020888 yiaA/B two helix domain; Region: YiaAB; cl01759 637910020889 HMMPfam hit to PF05360, YiaAB two helix, score 0.0002 637910020890 4 transmembrane helices predicted for ROD42431 by TMHMM2.0 at aa 7-24, 34-51, 64-83 and 93-110 637910020891 HMMPfam hit to PF05360, YiaAB two helix, score 0.0003 637910020892 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 637910020893 Acyltransferase family; Region: Acyl_transf_3; pfam01757 637910020894 HMMPfam hit to PF01757, Acyltransferase 3, score 4.3e-05 637910020895 10 transmembrane helices predicted for ROD42441 by TMHMM2.0 at aa 13-30, 45-67, 79-101, 114-136, 143-160, 175-194, 201-218, 233-255, 268-288 and 303-321 637910020896 YsaB-like lipoprotein; Region: YsaB; pfam13983 637910020897 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020898 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 637910020899 dimer interface [polypeptide binding]; other site 637910020900 motif 1; other site 637910020901 active site 637910020902 motif 2; other site 637910020903 motif 3; other site 637910020904 HMMPfam hit to PF02091, Glycyl-tRNA synthetase, class IIc, subunit alpha, score 1.8e-249 637910020905 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910020906 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 637910020907 DALR anticodon binding domain; Region: DALR_1; pfam05746 637910020908 anticodon binding site; other site 637910020909 tRNA binding surface [nucleotide binding]; other site 637910020910 HMMPfam hit to PF02092, Glycyl-tRNA synthetase, class IIc, beta subunit, N-terminal, score 0 637910020911 HMMPfam hit to PF05746, DALR anticodon binding, score 0.00013 637910020912 Hok/gef family; Region: HOK_GEF; cl11494 637910020913 HMMPfam hit to PF01848, Hok/gef cell toxic protein, score 6.4e-31 637910020914 1 transmembrane helix predicted for ROD42472 by TMHMM2.0 at aa 5-24 637910020915 PS00556 Hok/gef family cell toxic proteins signature. 637910020916 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020917 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 637910020918 DNA-binding site [nucleotide binding]; DNA binding site 637910020919 RNA-binding motif; other site 637910020920 HMMPfam hit to PF00313, Cold-shock protein, DNA-binding, score 1.2e-43 637910020921 PS00352 'Cold-shock' DNA-binding domain signature. 637910020922 Predicted transcriptional regulator [Transcription]; Region: COG2944 637910020923 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637910020924 non-specific DNA binding site [nucleotide binding]; other site 637910020925 salt bridge; other site 637910020926 sequence-specific DNA binding site [nucleotide binding]; other site 637910020927 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 1.3e-05 637910020928 Predicted helix-turn-helix motif with score 1367.000, SD 3.84 at aa 61-82, sequence LKIDDFARALGVSVAMVKEWES 637910020929 benzoate transport; Region: 2A0115; TIGR00895 637910020930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910020931 putative substrate translocation pore; other site 637910020932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910020933 12 transmembrane helices predicted for ROD42511 by TMHMM2.0 at aa 22-44, 59-78, 90-109, 114-136, 149-171, 176-198, 254-276, 291-313, 325-347, 351-373, 386-408 and 413-435 637910020934 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 6e-53 637910020935 PS00217 Sugar transport proteins signature 2. 637910020936 PS00216 Sugar transport proteins signature 1. 637910020937 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 637910020938 1 transmembrane helix predicted for ROD42521 by TMHMM2.0 at aa 10-27 637910020939 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020940 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 637910020941 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 637910020942 dimerization interface [polypeptide binding]; other site 637910020943 ligand binding site [chemical binding]; other site 637910020944 NADP binding site [chemical binding]; other site 637910020945 catalytic site [active] 637910020946 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region, score 1.3e-41 637910020947 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, score 7.6e-87 637910020948 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 637910020949 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 637910020950 putative outer membrane lipoprotein; Provisional; Region: PRK10510 637910020951 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 637910020952 ligand binding site [chemical binding]; other site 637910020953 HMMPfam hit to PF00691, Outer membrane protein, OmpA/MotB, C-terminal, score 8.3e-45 637910020954 PS01068 OmpA-like domain. 637910020955 HMMPfam hit to PF05433, Rickettsia 17 kDa surface antigen, score 4.3e-10 637910020956 3 transmembrane helices predicted for ROD42551 by TMHMM2.0 at aa 5-27, 37-55 and 62-81 637910020957 PS00017 ATP/GTP-binding site motif A (P-loop). 637910020958 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020959 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 637910020960 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 637910020961 molybdopterin cofactor binding site [chemical binding]; other site 637910020962 substrate binding site [chemical binding]; other site 637910020963 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 637910020964 molybdopterin cofactor binding site; other site 637910020965 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 2.4e-173 637910020966 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 637910020967 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 1.4e-28 637910020968 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 637910020969 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 637910020970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637910020971 Coenzyme A binding pocket [chemical binding]; other site 637910020972 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.7e-16 637910020973 pseudogene, truncated by frameshift mutation 637910020974 HMMPfam hit to PF03352, Methyladenine glycosylase, score 7.1e-132 637910020975 Autotransporter beta-domain; Region: Autotransporter; cl17461 637910020976 1 transmembrane helix predicted for ROD42591 by TMHMM2.0 at aa 13-35 637910020977 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 637910020978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910020979 putative substrate translocation pore; other site 637910020980 12 transmembrane helices predicted for ROD42601 by TMHMM2.0 at aa 12-34, 44-66, 73-95, 100-122, 135-154, 169-186, 217-236, 251-273, 280-302, 307-329, 342-361 and 365-387 637910020981 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.4e-33 637910020982 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020983 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910020984 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 637910020985 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910020986 HMMPfam hit to PF01609, Transposase, IS4-like, score 2.2e-25 637910020987 phosphoethanolamine transferase; Provisional; Region: PRK11560 637910020988 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 637910020989 Sulfatase; Region: Sulfatase; pfam00884 637910020990 5 transmembrane helices predicted for ROD42621 by TMHMM2.0 at aa 12-31, 46-68, 81-103, 118-140 and 161-178 637910020991 HMMPfam hit to PF08019, Protein of unknown function DUF1705, score 2.4e-06 637910020992 HMMPfam hit to PF00884, Sulphatase, score 1.6e-74 637910020993 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 637910020994 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 637910020995 peptide binding site [polypeptide binding]; other site 637910020996 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 1.3e-102 637910020997 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 637910020998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910020999 dimer interface [polypeptide binding]; other site 637910021000 conserved gate region; other site 637910021001 putative PBP binding loops; other site 637910021002 ABC-ATPase subunit interface; other site 637910021003 6 transmembrane helices predicted for ROD42641 by TMHMM2.0 at aa 9-31, 99-121, 134-156, 202-221, 258-280 and 309-331 637910021004 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 8e-55 637910021005 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910021006 dipeptide transporter; Provisional; Region: PRK10913 637910021007 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 637910021008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910021009 dimer interface [polypeptide binding]; other site 637910021010 conserved gate region; other site 637910021011 putative PBP binding loops; other site 637910021012 ABC-ATPase subunit interface; other site 637910021013 5 transmembrane helices predicted for ROD42651 by TMHMM2.0 at aa 31-53, 103-125, 140-162, 210-232 and 265-287 637910021014 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 8.4e-48 637910021015 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 637910021016 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637910021017 Walker A/P-loop; other site 637910021018 ATP binding site [chemical binding]; other site 637910021019 Q-loop/lid; other site 637910021020 ABC transporter signature motif; other site 637910021021 Walker B; other site 637910021022 D-loop; other site 637910021023 H-loop/switch region; other site 637910021024 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 637910021025 HMMPfam hit to PF00005, ABC transporter related, score 1.9e-60 637910021026 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021027 PS00211 ABC transporters family signature. 637910021028 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter C-terminal, score 9e-28 637910021029 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 637910021030 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637910021031 Walker A/P-loop; other site 637910021032 ATP binding site [chemical binding]; other site 637910021033 Q-loop/lid; other site 637910021034 ABC transporter signature motif; other site 637910021035 Walker B; other site 637910021036 D-loop; other site 637910021037 H-loop/switch region; other site 637910021038 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 637910021039 HMMPfam hit to PF00005, ABC transporter related, score 7.1e-60 637910021040 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021041 PS00211 ABC transporters family signature. 637910021042 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter C-terminal, score 4e-32 637910021043 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 637910021044 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 637910021045 11 transmembrane helices predicted for ROD42681 by TMHMM2.0 at aa 28-50, 55-72, 103-125, 145-167, 174-196, 211-233, 254-276, 304-326, 347-366, 376-398 and 411-430 637910021046 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021047 PS00307 Legume lectins beta-chain signature. 637910021048 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 637910021049 1 transmembrane helix predicted for ROD42682 by TMHMM2.0 at aa 10-32 637910021050 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 637910021051 4 transmembrane helices predicted for ROD42691 by TMHMM2.0 at aa 33-55, 68-85, 114-133 and 140-162 637910021052 Protein of unknown function (DUF2636); Region: DUF2636; cl11897 637910021053 1 transmembrane helix predicted for ROD42701 by TMHMM2.0 at aa 7-29 637910021054 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 637910021055 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 637910021056 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 637910021057 cell division protein; Provisional; Region: PRK10037 637910021058 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 637910021059 HMMPfam hit to PF06564, YhjQ, score 2.9e-125 637910021060 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 637910021061 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 637910021062 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 637910021063 DXD motif; other site 637910021064 PilZ domain; Region: PilZ; pfam07238 637910021065 10 transmembrane helices predicted for ROD42741 by TMHMM2.0 at aa 28-50, 145-167, 171-190, 197-216, 229-251, 522-541, 545-567, 588-610, 640-659 and 666-688 637910021066 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021067 PS00215 Mitochondrial energy transfer proteins signature. 637910021068 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021069 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 2e-25 637910021070 HMMPfam hit to PF03552, Cellulose synthase, score 7.3e-07 637910021071 HMMPfam hit to PF07238, type IV pilus assembly PilZ, score 1.9e-21 637910021072 cellulose synthase regulator protein; Provisional; Region: PRK11114 637910021073 HMMPfam hit to PF03170, Cellulose synthase, subunit B, score 0 637910021074 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 637910021075 1 transmembrane helix predicted for ROD42751 by TMHMM2.0 at aa 745-767 637910021076 endo-1,4-D-glucanase; Provisional; Region: PRK11097 637910021077 HMMPfam hit to PF01270, Glycoside hydrolase, family 8, score 1.2e-149 637910021078 PS00812 Glycosyl hydrolases family 8 signature. 637910021079 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 637910021080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637910021081 TPR motif; other site 637910021082 binding surface 637910021083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637910021084 TPR motif; other site 637910021085 binding surface 637910021086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637910021087 binding surface 637910021088 TPR motif; other site 637910021089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 637910021090 binding surface 637910021091 TPR motif; other site 637910021092 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 637910021093 HMMPfam hit to PF07719, Tetratricopeptide TPR2, score 2.1e-05 637910021094 HMMPfam hit to PF00515, Tetratricopeptide TPR-1, score 0.3 637910021095 HMMPfam hit to PF07719, Tetratricopeptide TPR2, score 0.0018 637910021096 HMMPfam hit to PF05420, Cellulose synthase operon C, C-terminal, score 4e-176 637910021097 putative diguanylate cyclase; Provisional; Region: PRK13561 637910021098 HAMP domain; Region: HAMP; pfam00672 637910021099 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637910021100 metal binding site [ion binding]; metal-binding site 637910021101 active site 637910021102 I-site; other site 637910021103 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637910021104 2 transmembrane helices predicted for ROD42781 by TMHMM2.0 at aa 5-24 and 145-167 637910021105 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 1.4e-06 637910021106 HMMPfam hit to PF00990, GGDEF, score 1.2e-07 637910021107 HMMPfam hit to PF00563, EAL, score 5.1e-111 637910021108 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 637910021109 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 637910021110 9 transmembrane helices predicted for ROD42791 by TMHMM2.0 at aa 5-27, 47-64, 77-99, 141-163, 184-206, 219-241, 289-311, 326-348 and 353-375 637910021111 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter, score 9.7e-213 637910021112 PS00713 Sodium:dicarboxylate symporter family signature 1. 637910021113 PS00714 Sodium:dicarboxylate symporter family signature 2. 637910021114 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 637910021115 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 637910021116 HMMPfam hit to PF00675, Peptidase M16, N-terminal, score 0.016 637910021117 HMMPfam hit to PF05193, Peptidase M16, C-terminal, score 2.5e-25 637910021118 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 637910021119 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 637910021120 substrate binding site [chemical binding]; other site 637910021121 ATP binding site [chemical binding]; other site 637910021122 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 8.2e-84 637910021123 PS00584 pfkB family of carbohydrate kinases signature 2. 637910021124 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637910021125 HMMPfam hit to PF00563, EAL, score 1.2e-39 637910021126 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 637910021127 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 637910021128 HMMPfam hit to PF05170, AsmA, score 2.1e-226 637910021129 1 transmembrane helix predicted for ROD42831 by TMHMM2.0 at aa 12-34 637910021130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910021131 metabolite-proton symporter; Region: 2A0106; TIGR00883 637910021132 putative substrate translocation pore; other site 637910021133 HMMPfam hit to PF00083, General substrate transporter score 1.8e-23 637910021134 11 transmembrane helices predicted for ROD42841 by TMHMM2.0 at aa 24-46, 66-88, 109-131, 166-188, 195-217, 247-269, 290-312, 322-341, 348-370, 380-402 and 409-431 637910021135 PS00216 Sugar transport proteins signature 1. 637910021136 PS00359 Ribosomal protein L11 signature. 637910021137 inner membrane protein YhjD; Region: TIGR00766 637910021138 HMMPfam hit to PF03631, Ribonuclease BN, score 1e-26 637910021139 6 transmembrane helices predicted for ROD42851 by TMHMM2.0 at aa 80-102, 139-161, 191-213, 233-255, 267-289 and 304-326 637910021140 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910021141 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910021142 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 637910021143 putative effector binding pocket; other site 637910021144 putative dimerization interface [polypeptide binding]; other site 637910021145 HMMPfam hit to PF03466, LysR, substrate-binding, score 6.2e-47 637910021146 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 9.2e-18 637910021147 PS00044 Bacterial regulatory proteins, lysR family signature. 637910021148 Predicted helix-turn-helix motif with score 1668.000, SD 4.87 at aa 17-38, sequence ESFSRAADALGLPKGSVSRQIQ 637910021149 pseudogene, truncated by two frameshift mutations 637910021150 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637910021151 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 637910021152 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910021153 DNA binding residues [nucleotide binding] 637910021154 dimerization interface [polypeptide binding]; other site 637910021155 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 1.1e-24 637910021156 PS00622 Bacterial regulatory proteins, luxR family signature. 637910021157 Predicted helix-turn-helix motif with score 1490.000, SD 4.26 at aa 157-178, sequence ESNKEIGRALNISTGTVKAHLE 637910021158 pseudogene, fragmented by internal deletion and frameshift mutation 637910021159 trehalase; Provisional; Region: treF; PRK13270 637910021160 Trehalase; Region: Trehalase; pfam01204 637910021161 HMMPfam hit to PF01204, Glycoside hydrolase, family 37, score 4e-254 637910021162 PS00928 Trehalase signature 2. 637910021163 PS00927 Trehalase signature 1. 637910021164 Haem-binding domain; Region: Haem_bd; pfam14376 637910021165 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 637910021166 1 transmembrane helix predicted for ROD42931 by TMHMM2.0 at aa 7-29 637910021167 PS00190 Cytochrome c family heme-binding site signature. 637910021168 HMMPfam hit to PF03150, Di-haem cytochrome c peroxidase, score 8.4e-113 637910021169 PS00190 Cytochrome c family heme-binding site signature. 637910021170 PS00190 Cytochrome c family heme-binding site signature. 637910021171 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 637910021172 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910021173 DNA-binding site [nucleotide binding]; DNA binding site 637910021174 UTRA domain; Region: UTRA; pfam07702 637910021175 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 1.6e-28 637910021176 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 5.7e-34 637910021177 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 637910021178 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 637910021179 putative active site [active] 637910021180 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 637910021181 dimer interface [polypeptide binding]; other site 637910021182 active site 637910021183 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 6.1e-10 637910021184 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 2.1e-16 637910021185 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 637910021186 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 637910021187 substrate binding site [chemical binding]; other site 637910021188 ATP binding site [chemical binding]; other site 637910021189 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 9.8e-10 637910021190 PS00583 pfkB family of carbohydrate kinases signature 1. 637910021191 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021192 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 637910021193 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 637910021194 HMMPfam hit to PF03605, Anaerobic c4-dicarboxylate membrane transporter score 2.2e-174 637910021195 11 transmembrane helices predicted for ROD42971 by TMHMM2.0 at aa 20-42, 52-74, 87-109, 163-185, 226-248, 263-282, 289-311, 331-350, 357-374, 379-398 and 419-438 637910021196 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021197 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 637910021198 active site 637910021199 homotetramer interface [polypeptide binding]; other site 637910021200 homodimer interface [polypeptide binding]; other site 637910021201 HMMPfam hit to PF00710, Asparaginase/glutaminase, score 1e-133 637910021202 PS00144 Asparaginase / glutaminase active site signature 1. 637910021203 PS00917 Asparaginase / glutaminase active site signature 2. 637910021204 glutathione reductase; Validated; Region: PRK06116 637910021205 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637910021206 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637910021207 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 637910021208 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 2.1e-52 637910021209 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 6.3e-69 637910021210 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 1.4e-31 637910021211 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 637910021212 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 637910021213 HMMPfam hit to PF04378, Protein of unknown function DUF519, score 1e-162 637910021214 PS00092 N-6 Adenine-specific DNA methylases signature. 637910021215 PS00092 N-6 Adenine-specific DNA methylases signature. 637910021216 oligopeptidase A; Provisional; Region: PRK10911 637910021217 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 637910021218 active site 637910021219 Zn binding site [ion binding]; other site 637910021220 HMMPfam hit to PF01432, Peptidase M3A and M3B, thimet/oligopeptidase F, score 2.6e-242 637910021221 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 637910021222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910021223 S-adenosylmethionine binding site [chemical binding]; other site 637910021224 HMMPfam hit to PF04445, Protein of unknown function DUF548, score 4.3e-167 637910021225 pseudogene, truncated by premature stop codon 637910021226 HMMPfam hit to PF00854, TGF-beta receptor, type I/II extracellular region, score 7.2e-108 637910021227 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 637910021228 Ligand Binding Site [chemical binding]; other site 637910021229 HMMPfam hit to PF00582, UspA, score 5.5e-17 637910021230 universal stress protein UspB; Provisional; Region: PRK04960 637910021231 1 transmembrane helix predicted for ROD43051 by TMHMM2.0 at aa 82-104 637910021232 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 637910021233 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 637910021234 10 transmembrane helices predicted for ROD43061 by TMHMM2.0 at aa 10-32, 52-74, 94-116, 123-145, 155-177, 207-224, 234-256, 381-403, 418-440 and 474-496 637910021235 HMMPfam hit to PF01384, Phosphate transporter score 1.1e-134 637910021236 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 637910021237 Predicted flavoproteins [General function prediction only]; Region: COG2081 637910021238 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637910021239 HMMPfam hit to PF03486, HI0933-like protein, score 3.5e-247 637910021240 pseudogene, truncated by premature stop codon 637910021241 Propionate catabolism activator; Region: PrpR_N; pfam06506 637910021242 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 637910021243 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910021244 Walker A motif; other site 637910021245 ATP binding site [chemical binding]; other site 637910021246 Walker B motif; other site 637910021247 arginine finger; other site 637910021248 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 637910021249 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 1.3e-14 637910021250 Predicted helix-turn-helix motif with score 1631.000, SD 4.74 at aa 600-621, sequence GDRTKAAVMLGISPTTLWRKLK 637910021251 PS00688 Sigma-54 interaction domain C-terminal part signature. 637910021252 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 6.5e-122 637910021253 HMMPfam hit to PF06506, Propionate catabolism activator, N-terminal, score 6.2e-08 637910021254 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 637910021255 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 637910021256 active site 637910021257 HMMPfam hit to PF01979, Amidohydrolase 1, score 2.8e-05 637910021258 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 637910021259 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 637910021260 HMMPfam hit to PF00939, Sodium/sulphate symporter, score 1.9e-124 637910021261 13 transmembrane helices predicted for ROD43111 by TMHMM2.0 at aa 2-19, 29-45, 52-74, 79-98, 170-192, 207-229, 262-279, 283-305, 318-340, 355-372, 379-398, 408-430 and 437-459 637910021262 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021263 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021264 hypothetical protein; Validated; Region: PRK06201 637910021265 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 637910021266 HMMPfam hit to PF03737, Ribonuclease E inhibitor RraA/Dimethylmenaquinone methyltransferase, score 1.5e-31 637910021267 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 637910021268 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 637910021269 ligand binding site [chemical binding]; other site 637910021270 NAD binding site [chemical binding]; other site 637910021271 dimerization interface [polypeptide binding]; other site 637910021272 catalytic site [active] 637910021273 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region, score 4.9e-28 637910021274 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, score 4.1e-72 637910021275 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 637910021276 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 637910021277 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 637910021278 HicB family; Region: HicB; pfam05534 637910021279 HMMPfam hit to PF05534, HicB, score 1.1e-20 637910021280 nickel responsive regulator; Provisional; Region: PRK02967 637910021281 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 637910021282 HMMPfam hit to PF08753, NikR C terminal nickel binding, score 7.8e-41 637910021283 HMMPfam hit to PF01402, CopG-like DNA-binding, score 1.1e-12 637910021284 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 637910021285 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637910021286 Walker A/P-loop; other site 637910021287 ATP binding site [chemical binding]; other site 637910021288 Q-loop/lid; other site 637910021289 ABC transporter signature motif; other site 637910021290 Walker B; other site 637910021291 D-loop; other site 637910021292 H-loop/switch region; other site 637910021293 HMMPfam hit to PF00005, ABC transporter related, score 2e-72 637910021294 PS00211 ABC transporters family signature. 637910021295 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021296 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 637910021297 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 637910021298 Walker A/P-loop; other site 637910021299 ATP binding site [chemical binding]; other site 637910021300 Q-loop/lid; other site 637910021301 ABC transporter signature motif; other site 637910021302 Walker B; other site 637910021303 D-loop; other site 637910021304 H-loop/switch region; other site 637910021305 HMMPfam hit to PF00005, ABC transporter related, score 6.6e-53 637910021306 PS00211 ABC transporters family signature. 637910021307 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021308 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 637910021309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910021310 dimer interface [polypeptide binding]; other site 637910021311 conserved gate region; other site 637910021312 putative PBP binding loops; other site 637910021313 ABC-ATPase subunit interface; other site 637910021314 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 7.2e-47 637910021315 6 transmembrane helices predicted for ROD43191 by TMHMM2.0 at aa 13-32, 78-100, 121-143, 179-198, 205-227 and 242-260 637910021316 nickel transporter permease NikB; Provisional; Region: PRK10352 637910021317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910021318 dimer interface [polypeptide binding]; other site 637910021319 conserved gate region; other site 637910021320 putative PBP binding loops; other site 637910021321 ABC-ATPase subunit interface; other site 637910021322 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.2e-67 637910021323 6 transmembrane helices predicted for ROD43201 by TMHMM2.0 at aa 9-31, 101-123, 136-158, 173-195, 230-252 and 280-302 637910021324 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 637910021325 substrate binding site [chemical binding]; other site 637910021326 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 637910021327 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 1.2e-74 637910021328 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910021329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910021330 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637910021331 dimerization interface [polypeptide binding]; other site 637910021332 HMMPfam hit to PF03466, LysR, substrate-binding, score 5.8e-13 637910021333 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 9.5e-17 637910021334 Predicted helix-turn-helix motif with score 1363.000, SD 3.83 at aa 19-40, sequence GSFARAAEATHRSQSSVSYNLA 637910021335 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 637910021336 HMMPfam hit to PF05870, Phenolic acid decarboxylase, bacterial, score 2e-102 637910021337 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 637910021338 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 637910021339 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase, score 0.00049 637910021340 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 637910021341 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 637910021342 dimer interface [polypeptide binding]; other site 637910021343 active site 637910021344 HMMPfam hit to PF02801, beta-ketoacyl synthase, C-terminal, score 1.1e-39 637910021345 HMMPfam hit to PF00109, beta-ketoacyl synthase, N-terminal, score 1.4e-45 637910021346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 637910021347 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 637910021348 NAD(P) binding site [chemical binding]; other site 637910021349 active site 637910021350 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 8e-31 637910021351 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 637910021352 putative active site 1 [active] 637910021353 HMMPfam hit to PF07977, beta-hydroxyacyl-ACP dehydratase, FabA/FabZ, score 5.3e-06 637910021354 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021355 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 637910021356 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 637910021357 dimer interface [polypeptide binding]; other site 637910021358 active site 637910021359 HMMPfam hit to PF02801, beta-ketoacyl synthase, C-terminal, score 7.1e-32 637910021360 HMMPfam hit to PF00109, beta-ketoacyl synthase, N-terminal, score 5.7e-19 637910021361 PS00606 beta-ketoacyl synthases active site. 637910021362 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 637910021363 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021364 Predicted exporter [General function prediction only]; Region: COG4258 637910021365 12 transmembrane helices predicted for ROD43301 by TMHMM2.0 at aa 7-29, 252-271, 278-300, 304-326, 347-369, 373-395, 422-444, 623-645, 652-674, 678-700, 707-729 and 734-756 637910021366 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021367 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021368 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021369 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 637910021370 HMMPfam hit to PF03548, Outer membrane lipoprotein carrier protein LolA, score 0.00062 637910021371 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 637910021372 active site 637910021373 HMMPfam hit to PF03061, Thioesterase superfamily, score 3e-10 637910021374 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 637910021375 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 637910021376 Ligand binding site; other site 637910021377 Putative Catalytic site; other site 637910021378 DXD motif; other site 637910021379 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 637910021380 putative acyl-acceptor binding pocket; other site 637910021381 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 4.2e-15 637910021382 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 637910021383 active site 2 [active] 637910021384 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 637910021385 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 637910021386 acyl-activating enzyme (AAE) consensus motif; other site 637910021387 active site 637910021388 AMP binding site [chemical binding]; other site 637910021389 CoA binding site [chemical binding]; other site 637910021390 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 637910021391 CoA binding site [chemical binding]; other site 637910021392 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 4.4e-09 637910021393 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 7.1e-06 637910021394 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021395 Predicted membrane protein [Function unknown]; Region: COG4648 637910021396 6 transmembrane helices predicted for ROD43361 by TMHMM2.0 at aa 7-29, 33-50, 62-80, 85-107, 137-156 and 161-183 637910021397 acyl carrier protein; Provisional; Region: PRK05350 637910021398 HMMPfam hit to PF00550, Phosphopantetheine-binding, score 1.6e-10 637910021399 Phosphopantetheine attachment site; Region: PP-binding; cl09936 637910021400 PS00012 Phosphopantetheine attachment site. 637910021401 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 637910021402 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 637910021403 putative acyl-acceptor binding pocket; other site 637910021404 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 1.9e-16 637910021405 1 transmembrane helix predicted for ROD43391 by TMHMM2.0 at aa 21-43 637910021406 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 637910021407 Methyltransferase domain; Region: Methyltransf_31; pfam13847 637910021408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910021409 S-adenosylmethionine binding site [chemical binding]; other site 637910021410 HMMPfam hit to PF08242, Methyltransferase type 12, score 2.4e-10 637910021411 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021412 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 637910021413 Domain of unknown function DUF20; Region: UPF0118; pfam01594 637910021414 HMMPfam hit to PF01594, Protein of unknown function UPF0118, score 1.1e-92 637910021415 8 transmembrane helices predicted for ROD43431 by TMHMM2.0 at aa 12-29, 33-55, 62-84, 144-163, 192-214, 224-246, 253-275 and 295-317 637910021416 major facilitator superfamily transporter; Provisional; Region: PRK05122 637910021417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910021418 putative substrate translocation pore; other site 637910021419 12 transmembrane helices predicted for ROD43441 by TMHMM2.0 at aa 20-42, 47-69, 85-107, 122-144, 151-173, 177-199, 220-242, 252-271, 278-300, 310-332, 339-361 and 366-388 637910021420 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.1e-21 637910021421 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021422 hypothetical protein; Provisional; Region: PRK11615 637910021423 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021424 hypothetical protein; Provisional; Region: PRK11212 637910021425 6 transmembrane helices predicted for ROD43461 by TMHMM2.0 at aa 13-35, 45-64, 71-93, 108-130, 142-164 and 179-201 637910021426 HMMPfam hit to PF02592, Protein of unknown function DUF165, score 1.5e-72 637910021427 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 637910021428 CPxP motif; other site 637910021429 HMMPfam hit to PF01206, SirA-like, score 4.6e-39 637910021430 PS01148 Uncharacterized protein family UPF0033 signature. 637910021431 Protein of unknown function (DUF796); Region: DUF796; cl01226 637910021432 HMMPfam hit to PF05638, Virulence factor for secretion apparatus, score 1.1e-38 637910021433 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 637910021434 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 637910021435 HMMPfam hit to PF03480, TRAP dicarboxylate transporter- DctP subunit, score 2.5e-84 637910021436 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 637910021437 4 transmembrane helices predicted for ROD43501 by TMHMM2.0 at aa 13-35, 50-72, 93-115 and 135-154 637910021438 HMMPfam hit to PF04290, Tripartite ATP-independent periplasmic transporter DctQ component, score 2.1e-17 637910021439 DctM-like transporters; Region: DctM; pfam06808 637910021440 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 637910021441 11 transmembrane helices predicted for ROD43511 by TMHMM2.0 at aa 5-27, 42-64, 77-99, 171-193, 214-236, 240-257, 277-299, 314-331, 336-353, 363-385 and 398-420 637910021442 HMMPfam hit to PF06808, TRAP C4-dicarboxylate transport system permease DctM subunit, score 3.3e-145 637910021443 PS00211 ABC transporters family signature. 637910021444 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 637910021445 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 637910021446 metal-binding site [ion binding] 637910021447 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 637910021448 PS00141 Eukaryotic and viral aspartyl proteases active site. 637910021449 5 transmembrane helices predicted for ROD43521 by TMHMM2.0 at aa 147-169, 189-211, 350-372, 387-409 and 690-712 637910021450 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 7.7e-31 637910021451 PS01229 Hypothetical cof family signature 2. 637910021452 PS00154 E1-E2 ATPases phosphorylation site. 637910021453 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 5.4e-92 637910021454 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910021455 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910021456 HMMPfam hit to PF00403, Heavy metal transport/detoxification protein, score 2.8e-13 637910021457 PS01047 Heavy-metal-associated domain. 637910021458 Predicted membrane protein [Function unknown]; Region: COG3714 637910021459 HMMPfam hit to PF07947, YhhN-like, score 2.1e-61 637910021460 6 transmembrane helices predicted for ROD43531 by TMHMM2.0 at aa 28-45, 50-72, 77-96, 101-123, 130-152 and 156-178 637910021461 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 637910021462 1 transmembrane helix predicted for ROD43541 by TMHMM2.0 at aa 5-24 637910021463 hypothetical protein; Provisional; Region: PRK10910 637910021464 HMMPfam hit to PF06611, Protein of unknown function DUF1145, score 1.4e-36 637910021465 2 transmembrane helices predicted for ROD43551 by TMHMM2.0 at aa 7-26 and 36-58 637910021466 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 637910021467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910021468 S-adenosylmethionine binding site [chemical binding]; other site 637910021469 HMMPfam hit to PF03602, Conserved hypothetical protein CHP00095, score 2e-89 637910021470 PS00092 N-6 Adenine-specific DNA methylases signature. 637910021471 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 637910021472 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 637910021473 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 637910021474 P loop; other site 637910021475 GTP binding site [chemical binding]; other site 637910021476 HMMPfam hit to PF02881, Signal recognition particle, SRP54 subunit, helical bundle, score 7.2e-20 637910021477 HMMPfam hit to PF00448, Signal recognition particle, SRP54 subunit, GTPase, score 5.5e-128 637910021478 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021479 PS00300 SRP54-type proteins GTP-binding domain signature. 637910021480 cell division protein FtsE; Provisional; Region: PRK10908 637910021481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910021482 Walker A/P-loop; other site 637910021483 ATP binding site [chemical binding]; other site 637910021484 Q-loop/lid; other site 637910021485 ABC transporter signature motif; other site 637910021486 Walker B; other site 637910021487 D-loop; other site 637910021488 H-loop/switch region; other site 637910021489 HMMPfam hit to PF00005, ABC transporter related, score 5e-75 637910021490 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021491 PS00211 ABC transporters family signature. 637910021492 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 637910021493 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 637910021494 4 transmembrane helices predicted for ROD43591 by TMHMM2.0 at aa 73-95, 219-241, 272-294 and 324-343 637910021495 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 7.3e-23 637910021496 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 637910021497 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 637910021498 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 637910021499 DNA binding residues [nucleotide binding] 637910021500 HMMPfam hit to PF04542, RNA polymerase sigma-70 region 2, score 5.3e-22 637910021501 PS00715 Sigma-70 factors family signature 1. 637910021502 HMMPfam hit to PF04545, RNA polymerase sigma-70 region 4, score 3.1e-20 637910021503 Predicted helix-turn-helix motif with score 2058.000, SD 6.20 at aa 251-272, sequence STLQELADRYGVSAERVRQLEK 637910021504 PS00716 Sigma-70 factors family signature 2. 637910021505 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 637910021506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910021507 DNA-binding site [nucleotide binding]; DNA binding site 637910021508 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 637910021509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910021510 homodimer interface [polypeptide binding]; other site 637910021511 catalytic residue [active] 637910021512 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021513 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 2.4e-08 637910021514 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 1e-20 637910021515 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 637910021516 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 637910021517 inhibitor-cofactor binding pocket; inhibition site 637910021518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910021519 catalytic residue [active] 637910021520 HMMPfam hit to PF00202, Aminotransferase class-III, score 4.5e-150 637910021521 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 637910021522 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 637910021523 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 637910021524 11 transmembrane helices predicted for ROD43641 by TMHMM2.0 at aa 21-43, 53-75, 95-117, 122-144, 149-167, 182-201, 221-243, 263-285, 305-327, 332-349 and 376-398 637910021525 HMMPfam hit to PF03222, Aromatic amino acid permease, score 1.5e-09 637910021526 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 637910021527 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 637910021528 dimerization interface [polypeptide binding]; other site 637910021529 ligand binding site [chemical binding]; other site 637910021530 HMMPfam hit to PF01094, Extracellular ligand-binding receptor, score 6.1e-73 637910021531 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 637910021532 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 0.0007 637910021533 1 transmembrane helix predicted for ROD43671 by TMHMM2.0 at aa 12-34 637910021534 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 637910021535 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 637910021536 dimerization interface [polypeptide binding]; other site 637910021537 ligand binding site [chemical binding]; other site 637910021538 HMMPfam hit to PF01094, Extracellular ligand-binding receptor, score 4.4e-72 637910021539 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 637910021540 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 637910021541 TM-ABC transporter signature motif; other site 637910021542 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 1.9e-69 637910021543 8 transmembrane helices predicted for ROD43691 by TMHMM2.0 at aa 15-37, 44-66, 70-92, 105-124, 153-175, 207-229, 244-266 and 282-301 637910021544 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 637910021545 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 637910021546 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 637910021547 TM-ABC transporter signature motif; other site 637910021548 10 transmembrane helices predicted for ROD43701 by TMHMM2.0 at aa 4-26, 47-66, 91-108, 120-142, 162-184, 193-210, 261-283, 315-337, 352-374 and 381-400 637910021549 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 1.6e-74 637910021550 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 637910021551 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 637910021552 Walker A/P-loop; other site 637910021553 ATP binding site [chemical binding]; other site 637910021554 Q-loop/lid; other site 637910021555 ABC transporter signature motif; other site 637910021556 Walker B; other site 637910021557 D-loop; other site 637910021558 H-loop/switch region; other site 637910021559 HMMPfam hit to PF00005, ABC transporter related, score 4.6e-57 637910021560 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021561 PS00211 ABC transporters family signature. 637910021562 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 637910021563 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 637910021564 Walker A/P-loop; other site 637910021565 ATP binding site [chemical binding]; other site 637910021566 Q-loop/lid; other site 637910021567 ABC transporter signature motif; other site 637910021568 Walker B; other site 637910021569 D-loop; other site 637910021570 H-loop/switch region; other site 637910021571 HMMPfam hit to PF00005, ABC transporter related, score 6.1e-56 637910021572 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021573 PS00211 ABC transporters family signature. 637910021574 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 637910021575 HMMPfam hit to PF02604, Protein of unknown function DUF172, score 2.7e-14 637910021576 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 637910021577 HMMPfam hit to PF05012, Death-on-curing protein, score 3.6e-36 637910021578 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 637910021579 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 637910021580 1 transmembrane helix predicted for ROD43751 by TMHMM2.0 at aa 7-29 637910021581 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 8.3e-26 637910021582 PS01037 Bacterial extracellular solute-binding proteins, family 1 signature. 637910021583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 637910021584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910021585 dimer interface [polypeptide binding]; other site 637910021586 putative PBP binding loops; other site 637910021587 ABC-ATPase subunit interface; other site 637910021588 6 transmembrane helices predicted for ROD43761 by TMHMM2.0 at aa 12-34, 72-94, 115-137, 157-179, 206-228 and 263-285 637910021589 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 9.8e-19 637910021590 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910021591 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 637910021592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910021593 dimer interface [polypeptide binding]; other site 637910021594 conserved gate region; other site 637910021595 putative PBP binding loops; other site 637910021596 ABC-ATPase subunit interface; other site 637910021597 6 transmembrane helices predicted for ROD43771 by TMHMM2.0 at aa 13-35, 82-104, 111-130, 145-162, 200-222 and 245-267 637910021598 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.2e-28 637910021599 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910021600 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 637910021601 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 637910021602 Walker A/P-loop; other site 637910021603 ATP binding site [chemical binding]; other site 637910021604 Q-loop/lid; other site 637910021605 ABC transporter signature motif; other site 637910021606 Walker B; other site 637910021607 D-loop; other site 637910021608 H-loop/switch region; other site 637910021609 TOBE domain; Region: TOBE_2; pfam08402 637910021610 HMMPfam hit to PF00005, ABC transporter related, score 7.9e-58 637910021611 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021612 PS00211 ABC transporters family signature. 637910021613 HMMPfam hit to PF08402, Transport-associated OB, type 2, score 3.7e-15 637910021614 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 637910021615 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 637910021616 putative active site [active] 637910021617 catalytic site [active] 637910021618 putative metal binding site [ion binding]; other site 637910021619 HMMPfam hit to PF03009, Glycerophosphoryl diester phosphodiesterase, score 3.1e-60 637910021620 hypothetical protein; Provisional; Region: PRK10350 637910021621 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 637910021622 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 637910021623 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021624 HMMPfam hit to PF01019, Gamma-glutamyltranspeptidase, score 4.9e-283 637910021625 PS00462 Gamma-glutamyltranspeptidase signature. 637910021626 Protein of unknown function (DUF796); Region: DUF796; cl01226 637910021627 HMMPfam hit to PF05638, Virulence factor for secretion apparatus, score 7.7e-40 637910021628 putative acetyltransferase YhhY; Provisional; Region: PRK10140 637910021629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637910021630 Coenzyme A binding pocket [chemical binding]; other site 637910021631 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.1e-21 637910021632 putative oxidoreductase; Provisional; Region: PRK10206 637910021633 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637910021634 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 637910021635 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 5.2e-35 637910021636 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021637 HMMPfam hit to PF02894, Oxidoreductase, C-terminal, score 1e-19 637910021638 Pirin-related protein [General function prediction only]; Region: COG1741 637910021639 Pirin; Region: Pirin; pfam02678 637910021640 HMMPfam hit to PF02678, Pirin, N-terminal, score 1.9e-65 637910021641 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 637910021642 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 637910021643 DNA binding site [nucleotide binding] 637910021644 domain linker motif; other site 637910021645 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 637910021646 putative ligand binding site [chemical binding]; other site 637910021647 putative dimerization interface [polypeptide binding]; other site 637910021648 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 3.8e-10 637910021649 Predicted helix-turn-helix motif with score 1844.000, SD 5.47 at aa 6-27, sequence PVLQDVADRVGVTKMTVSRFLR 637910021650 PS00356 Bacterial regulatory proteins, lacI family signature. 637910021651 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 5.1e-24 637910021652 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 637910021653 ATP-binding site [chemical binding]; other site 637910021654 Gluconate-6-phosphate binding site [chemical binding]; other site 637910021655 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021656 HMMPfam hit to PF01202, Shikimate kinase, score 8.3e-08 637910021657 low affinity gluconate transporter; Provisional; Region: PRK10472 637910021658 gluconate transporter; Region: gntP; TIGR00791 637910021659 HMMPfam hit to PF02447, Gluconate transporter score 4.3e-239 637910021660 11 transmembrane helices predicted for ROD43901 by TMHMM2.0 at aa 5-24, 36-58, 83-105, 118-140, 155-177, 207-229, 239-261, 274-296, 311-333, 365-387 and 402-424 637910021661 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021662 putative antibiotic transporter; Provisional; Region: PRK10739 637910021663 HMMPfam hit to PF01914, Multiple antibiotic resistance (MarC)-related proteins, score 1.7e-91 637910021664 6 transmembrane helices predicted for ROD43911 by TMHMM2.0 at aa 4-26, 38-57, 72-94, 106-128, 138-160 and 173-195 637910021665 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 637910021666 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 637910021667 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD - binding, score 1.7e-36 637910021668 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisation region, score 3.2e-84 637910021669 PS01103 Aspartate-semialdehyde dehydrogenase signature. 637910021670 glycogen branching enzyme; Provisional; Region: PRK05402 637910021671 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 637910021672 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 637910021673 active site 637910021674 catalytic site [active] 637910021675 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 637910021676 HMMPfam hit to PF02922, Glycoside hydrolase, family 13, N-terminal, score 1.4e-39 637910021677 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 6.3e-12 637910021678 HMMPfam hit to PF02806, Alpha-amylase, C-terminal all beta, score 1.9e-40 637910021679 glycogen debranching enzyme; Provisional; Region: PRK03705 637910021680 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 637910021681 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 637910021682 active site 637910021683 catalytic site [active] 637910021684 HMMPfam hit to PF02922, Glycoside hydrolase, family 13, N-terminal, score 6.8e-30 637910021685 PS00062 Aldo/keto reductase family signature 2. 637910021686 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 2.1e-11 637910021687 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 637910021688 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 637910021689 ligand binding site; other site 637910021690 oligomer interface; other site 637910021691 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 637910021692 dimer interface [polypeptide binding]; other site 637910021693 N-terminal domain interface [polypeptide binding]; other site 637910021694 sulfate 1 binding site; other site 637910021695 HMMPfam hit to PF00483, Nucleotidyl transferase, score 1.4e-101 637910021696 PS00808 ADP-glucose pyrophosphorylase signature 1. 637910021697 PS00809 ADP-glucose pyrophosphorylase signature 2. 637910021698 PS00810 ADP-glucose pyrophosphorylase signature 3. 637910021699 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021700 glycogen synthase; Provisional; Region: glgA; PRK00654 637910021701 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 637910021702 ADP-binding pocket [chemical binding]; other site 637910021703 homodimer interface [polypeptide binding]; other site 637910021704 HMMPfam hit to PF08323, Starch synthase catalytic region, score 5.4e-124 637910021705 PS00589 PTS HPR component serine phosphorylation site signature. 637910021706 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 1e-09 637910021707 glycogen phosphorylase; Provisional; Region: PRK14986 637910021708 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 637910021709 homodimer interface [polypeptide binding]; other site 637910021710 active site pocket [active] 637910021711 HMMPfam hit to PF00343, Glycosyl transferase, family 35, score 0 637910021712 PS00102 Phosphorylase pyridoxal-phosphate attachment site. 637910021713 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 637910021714 PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. 637910021715 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 1e-71 637910021716 PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1. 637910021717 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 637910021718 active site residue [active] 637910021719 HMMPfam hit to PF00581, Rhodanese-like, score 1.3e-17 637910021720 intramembrane serine protease GlpG; Provisional; Region: PRK10907 637910021721 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 637910021722 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 637910021723 6 transmembrane helices predicted for ROD44001 by TMHMM2.0 at aa 98-120, 140-162, 169-188, 192-214, 221-240 and 244-266 637910021724 HMMPfam hit to PF01694, Peptidase S54, rhomboid, score 5.9e-41 637910021725 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 637910021726 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 637910021727 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637910021728 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 5.1e-30 637910021729 PS00894 Bacterial regulatory proteins, deoR family signature. 637910021730 Predicted helix-turn-helix motif with score 1617.000, SD 4.69 at aa 20-41, sequence VSTEELVEHFSVSPQTIRRDLN 637910021731 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 1.1e-83 637910021732 transcriptional regulator MalT; Provisional; Region: PRK04841 637910021733 AAA ATPase domain; Region: AAA_16; pfam13191 637910021734 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910021735 DNA binding residues [nucleotide binding] 637910021736 dimerization interface [polypeptide binding]; other site 637910021737 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 3.4e-24 637910021738 PS00622 Bacterial regulatory proteins, luxR family signature. 637910021739 3 transmembrane helices predicted for ROD44031 by TMHMM2.0 at aa 5-27, 48-70 and 85-107 637910021740 1 transmembrane helix predicted for ROD44041 by TMHMM2.0 at aa 211-245 637910021741 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910021742 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 637910021743 HMMPfam hit to PF05638, Virulence factor for secretion apparatus, score 1.1e-39 637910021744 maltodextrin phosphorylase; Provisional; Region: PRK14985 637910021745 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 637910021746 homodimer interface [polypeptide binding]; other site 637910021747 active site pocket [active] 637910021748 HMMPfam hit to PF00343, Glycosyl transferase, family 35, score 0 637910021749 PS00102 Phosphorylase pyridoxal-phosphate attachment site. 637910021750 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 637910021751 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 637910021752 HMMPfam hit to PF02446, Glycoside hydrolase, family 77, score 2.2e-256 637910021753 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021754 high-affinity gluconate transporter; Provisional; Region: PRK14984 637910021755 gluconate transporter; Region: gntP; TIGR00791 637910021756 HMMPfam hit to PF02447, Gluconate transporter score 1.6e-271 637910021757 10 transmembrane helices predicted for ROD44081 by TMHMM2.0 at aa 7-27, 37-59, 80-98, 103-125, 159-181, 242-264, 277-296, 333-355, 362-384 and 399-421 637910021758 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021759 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 637910021760 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 637910021761 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 637910021762 HMMPfam hit to PF01106, NIF system FeS cluster assembly, NifU, C-terminal, score 1.3e-06 637910021763 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021764 HMMPfam hit to PF01521, HesB/YadR/YfhF, score 2.7e-34 637910021765 DNA utilization protein GntX; Provisional; Region: PRK11595 637910021766 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 637910021767 active site 637910021768 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 2.8e-06 637910021769 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021770 carboxylesterase BioH; Provisional; Region: PRK10349 637910021771 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 637910021772 HMMPfam hit to PF00561, Alpha/beta hydrolase fold-1, score 1.5e-37 637910021773 hypothetical protein; Provisional; Region: PRK09956 637910021774 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 637910021775 HMMPfam hit to PF04754, Transposase (), YhgA-like, score 1.1e-203 637910021776 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 637910021777 HMMPfam hit to PF09012, Protein of unknown function DUF1920, score 1.4e-55 637910021778 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 637910021779 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 637910021780 G1 box; other site 637910021781 GTP/Mg2+ binding site [chemical binding]; other site 637910021782 Switch I region; other site 637910021783 G2 box; other site 637910021784 G3 box; other site 637910021785 Switch II region; other site 637910021786 G4 box; other site 637910021787 G5 box; other site 637910021788 Nucleoside recognition; Region: Gate; pfam07670 637910021789 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 637910021790 Nucleoside recognition; Region: Gate; pfam07670 637910021791 10 transmembrane helices predicted for ROD44141 by TMHMM2.0 at aa 277-299, 309-331, 344-366, 386-408, 429-447, 451-473, 510-532, 663-685, 692-714 and 720-742 637910021792 HMMPfam hit to PF07670, Nucleoside recognition, score 4.8e-18 637910021793 HMMPfam hit to PF07664, Ferrous iron transport B, C-terminal, score 3e-23 637910021794 HMMPfam hit to PF07670, Nucleoside recognition, score 3.1e-16 637910021795 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021796 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021797 HMMPfam hit to PF02421, Ferrous iron transport protein B, N-terminal, score 9e-46 637910021798 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 1.2e-38 637910021799 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021800 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 637910021801 HMMPfam hit to PF04023, Ferrous iron transporter FeoA subunit, score 3.9e-07 637910021802 1 transmembrane helix predicted for ROD44161 by TMHMM2.0 at aa 15-36 637910021803 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 637910021804 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 637910021805 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 637910021806 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 637910021807 RNA binding site [nucleotide binding]; other site 637910021808 HMMPfam hit to PF00575, S1, RNA binding, score 1.4e-30 637910021809 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 637910021810 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 637910021811 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 637910021812 HMMPfam hit to PF01272, Transcription elongation factor, GreA/GreB region, prokaryotic, score 7.9e-45 637910021813 PS00830 Prokaryotic transcription elongation factors signature 2. 637910021814 HMMPfam hit to PF03449, Transcription elongation factor, GreA/GreB region, prokaryotic, score 1.1e-43 637910021815 PS00829 Prokaryotic transcription elongation factors signature 1. 637910021816 osmolarity response regulator; Provisional; Region: ompR; PRK09468 637910021817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910021818 active site 637910021819 phosphorylation site [posttranslational modification] 637910021820 intermolecular recognition site; other site 637910021821 dimerization interface [polypeptide binding]; other site 637910021822 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637910021823 DNA binding site [nucleotide binding] 637910021824 HMMPfam hit to PF00072, Response regulator receiver, score 5.9e-44 637910021825 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 4.3e-20 637910021826 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 637910021827 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637910021828 dimerization interface [polypeptide binding]; other site 637910021829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637910021830 dimer interface [polypeptide binding]; other site 637910021831 phosphorylation site [posttranslational modification] 637910021832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910021833 ATP binding site [chemical binding]; other site 637910021834 G-X-G motif; other site 637910021835 1 transmembrane helix predicted for ROD44201 by TMHMM2.0 at aa 12-34 637910021836 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 637910021837 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 1.3e-10 637910021838 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 1.7e-13 637910021839 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.1e-34 637910021840 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 637910021841 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 637910021842 active site 637910021843 substrate-binding site [chemical binding]; other site 637910021844 metal-binding site [ion binding] 637910021845 ATP binding site [chemical binding]; other site 637910021846 HMMPfam hit to PF01293, Phosphoenolpyruvate carboxykinase, ATP-utilising, score 0 637910021847 PS00532 Phosphoenolpyruvate carboxykinase (ATP) signature. 637910021848 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021849 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 637910021850 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 637910021851 dimerization interface [polypeptide binding]; other site 637910021852 domain crossover interface; other site 637910021853 redox-dependent activation switch; other site 637910021854 HMMPfam hit to PF01430, Hsp33 protein, score 2.9e-145 637910021855 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637910021856 RNA binding surface [nucleotide binding]; other site 637910021857 HMMPfam hit to PF01479, RNA-binding S4, score 3.3e-12 637910021858 GMP/IMP nucleotidase; Provisional; Region: PRK14988 637910021859 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 637910021860 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.2e-22 637910021861 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 637910021862 HMMPfam hit to PF07095, Intracellular growth attenuator IgaA, score 0 637910021863 5 transmembrane helices predicted for ROD44251 by TMHMM2.0 at aa 4-21, 202-221, 225-247, 342-364 and 652-674 637910021864 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 637910021865 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 637910021866 ADP-ribose binding site [chemical binding]; other site 637910021867 dimer interface [polypeptide binding]; other site 637910021868 active site 637910021869 nudix motif; other site 637910021870 metal binding site [ion binding]; metal-binding site 637910021871 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 7.8e-16 637910021872 PS00893 mutT domain signature. 637910021873 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 637910021874 Transglycosylase; Region: Transgly; pfam00912 637910021875 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 637910021876 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 3.5e-25 637910021877 HMMPfam hit to PF00912, Glycosyl transferase, family 51, score 5.4e-93 637910021878 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021879 1 transmembrane helix predicted for ROD44271 by TMHMM2.0 at aa 7-29 637910021880 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021881 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 637910021882 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 637910021883 HMMPfam hit to PF05137, Fimbrial assembly, score 9.3e-22 637910021884 1 transmembrane helix predicted for ROD44291 by TMHMM2.0 at aa 20-42 637910021885 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 637910021886 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 637910021887 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 637910021888 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 637910021889 HMMPfam hit to PF07660, Secretin/TonB, short N-terminal, score 7.5e-05 637910021890 HMMPfam hit to PF03958, NolW-like, score 1.3e-11 637910021891 HMMPfam hit to PF00263, Bacterial type II and III secretion system protein, score 9.6e-86 637910021892 PS00875 Bacterial type II secretion system protein D signature. 637910021893 shikimate kinase; Reviewed; Region: aroK; PRK00131 637910021894 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 637910021895 ADP binding site [chemical binding]; other site 637910021896 magnesium binding site [ion binding]; other site 637910021897 putative shikimate binding site; other site 637910021898 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021899 HMMPfam hit to PF01202, Shikimate kinase, score 1.5e-81 637910021900 PS01128 Shikimate kinase signature. 637910021901 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 637910021902 active site 637910021903 dimer interface [polypeptide binding]; other site 637910021904 metal binding site [ion binding]; metal-binding site 637910021905 HMMPfam hit to PF01761, 3-dehydroquinate synthase AroB, score 8.7e-182 637910021906 cell division protein DamX; Validated; Region: PRK10905 637910021907 1 transmembrane helix predicted for ROD44351 by TMHMM2.0 at aa 91-113 637910021908 HMMPfam hit to PF05036, Sporulation/cell division region, bacteria, score 3.1e-17 637910021909 DNA adenine methylase; Provisional; Region: PRK10904 637910021910 HMMPfam hit to PF02086, D12 class N6 adenine-specific DNA methyltransferase, score 3e-98 637910021911 PS00092 N-6 Adenine-specific DNA methylases signature. 637910021912 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 637910021913 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 637910021914 substrate binding site [chemical binding]; other site 637910021915 hexamer interface [polypeptide binding]; other site 637910021916 metal binding site [ion binding]; metal-binding site 637910021917 HMMPfam hit to PF00834, Ribulose-phosphate 3-epimerase, score 3.3e-141 637910021918 PS01085 Ribulose-phosphate 3-epimerase family signature 1. 637910021919 PS01086 Ribulose-phosphate 3-epimerase family signature 2. 637910021920 phosphoglycolate phosphatase; Provisional; Region: PRK13222 637910021921 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910021922 motif II; other site 637910021923 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 5.1e-45 637910021924 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 637910021925 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 637910021926 active site 637910021927 HIGH motif; other site 637910021928 dimer interface [polypeptide binding]; other site 637910021929 KMSKS motif; other site 637910021930 HMMPfam hit to PF00579, Aminoacyl-tRNA synthetase, class Ib, score 5.7e-130 637910021931 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 637910021932 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 637910021933 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021934 siroheme synthase; Provisional; Region: cysG; PRK10637 637910021935 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 637910021936 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 637910021937 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 637910021938 active site 637910021939 SAM binding site [chemical binding]; other site 637910021940 homodimer interface [polypeptide binding]; other site 637910021941 HMMPfam hit to PF00590, Tetrapyrrole methylase, score 4.2e-101 637910021942 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021943 PS00840 Uroporphyrin-III C-methyltransferase signature 2. 637910021944 PS00839 Uroporphyrin-III C-methyltransferase signature 1. 637910021945 Predicted helix-turn-helix motif with score 1087.000, SD 2.89 at aa 149-170, sequence QHLGQVAHYAGKLRSRVKQQFA 637910021946 nitrite transporter NirC; Provisional; Region: PRK11562 637910021947 HMMPfam hit to PF01226, Formate/nitrite transporter score 4e-139 637910021948 6 transmembrane helices predicted for ROD44421 by TMHMM2.0 at aa 26-48, 58-80, 101-123, 150-172, 184-206 and 226-248 637910021949 PS01006 Formate and nitrite transporters signature 2. 637910021950 PS01005 Formate and nitrite transporters signature 1. 637910021951 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 637910021952 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 637910021953 nitrite reductase subunit NirD; Provisional; Region: PRK14989 637910021954 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637910021955 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 637910021956 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 637910021957 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 637910021958 HMMPfam hit to PF01077, Nitrite and sulphite reductase 4Fe-4S region, score 1.3e-47 637910021959 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 637910021960 HMMPfam hit to PF03460, Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like, score 1.3e-19 637910021961 HMMPfam hit to PF04324, BFD-like [2Fe-2S]-binding region, score 7.5e-25 637910021962 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 1.6e-52 637910021963 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 1.2e-29 637910021964 putative transporter; Provisional; Region: PRK03699 637910021965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910021966 putative substrate translocation pore; other site 637910021967 12 transmembrane helices predicted for ROD44451 by TMHMM2.0 at aa 12-34, 49-66, 78-95, 99-121, 134-156, 161-183, 204-226, 246-268, 273-292, 297-319, 332-354 and 359-381 637910021968 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 7.1e-18 637910021969 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910021970 PS00217 Sugar transport proteins signature 2. 637910021971 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 637910021972 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 637910021973 substrate binding site [chemical binding]; other site 637910021974 HMMPfam hit to PF00160, Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, score 3.9e-75 637910021975 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 637910021976 hypothetical protein; Provisional; Region: PRK10204 637910021977 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 637910021978 cell filamentation protein Fic; Provisional; Region: PRK10347 637910021979 HMMPfam hit to PF02661, Filamentation induced by cAMP protein Fic, score 1.7e-32 637910021980 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 637910021981 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 637910021982 glutamine binding [chemical binding]; other site 637910021983 catalytic triad [active] 637910021984 PS00678 Trp-Asp (WD) repeats signature. 637910021985 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 7.2e-83 637910021986 PS00442 Glutamine amidotransferases class-I active site. 637910021987 PS00017 ATP/GTP-binding site motif A (P-loop). 637910021988 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 637910021989 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 637910021990 inhibitor-cofactor binding pocket; inhibition site 637910021991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910021992 catalytic residue [active] 637910021993 HMMPfam hit to PF00202, Aminotransferase class-III, score 2.8e-182 637910021994 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 637910021995 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 637910021996 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 637910021997 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 637910021998 HMMPfam hit to PF05976, Protein of unknown function DUF893, YccS/YhfK, score 6.5e-09 637910021999 8 transmembrane helices predicted for ROD44511 by TMHMM2.0 at aa 21-43, 63-82, 89-111, 131-153, 411-433, 437-453, 458-477 and 487-506 637910022000 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022001 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 637910022002 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 637910022003 ligand binding site [chemical binding]; other site 637910022004 flexible hinge region; other site 637910022005 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 637910022006 putative switch regulator; other site 637910022007 non-specific DNA interactions [nucleotide binding]; other site 637910022008 DNA binding site [nucleotide binding] 637910022009 sequence specific DNA binding site [nucleotide binding]; other site 637910022010 putative cAMP binding site [chemical binding]; other site 637910022011 HMMPfam hit to PF00325, Bacterial regulatory protein, Crp, score 5.9e-17 637910022012 PS00042 Bacterial regulatory proteins, crp family signature. 637910022013 Predicted helix-turn-helix motif with score 2127.000, SD 6.43 at aa 168-189, sequence ITRQEIGQIVGCSRETVGRILK 637910022014 HMMPfam hit to PF00027, Cyclic nucleotide-binding, score 5.7e-29 637910022015 PS00889 Cyclic nucleotide-binding domain signature 2. 637910022016 PS00888 Cyclic nucleotide-binding domain signature 1. 637910022017 hypothetical protein; Provisional; Region: PRK10738 637910022018 HMMPfam hit to PF02566, OsmC-like protein, score 9e-27 637910022019 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 637910022020 active site 637910022021 HMMPfam hit to PF00485, Phosphoribulokinase/uridine kinase, score 1.6e-121 637910022022 PS00567 Phosphoribulokinase signature. 637910022023 hypothetical protein; Provisional; Region: PRK04966 637910022024 HMMPfam hit to PF06794, Protein of unknown function UPF0270, score 9e-50 637910022025 putative hydrolase; Provisional; Region: PRK10985 637910022026 HMMPfam hit to PF00561, Alpha/beta hydrolase fold-1, score 1.5e-25 637910022027 PS01133 Uncharacterized protein family UPF0017 signature. 637910022028 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 637910022029 Coenzyme A transferase; Region: CoA_trans; cl17247 637910022030 HMMPfam hit to PF01144, Coenzyme A transferase, score 2.3e-05 637910022031 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 637910022032 HMMPfam hit to PF01874, Triphosphoribosyl-dephospho-CoA protein, score 2.6e-92 637910022033 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 637910022034 HMMPfam hit to PF06857, malonate decarboxylase delta subunit, score 1.6e-41 637910022035 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 637910022036 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022037 1 transmembrane helix predicted for ROD44601 by TMHMM2.0 at aa 147-169 637910022038 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 637910022039 HMMPfam hit to PF06833, malonate decarboxylase gamma subunit, score 1.9e-141 637910022040 Membrane transport protein; Region: Mem_trans; cl09117 637910022041 10 transmembrane helices predicted for ROD44621 by TMHMM2.0 at aa 4-23, 36-58, 68-90, 97-119, 129-151, 181-203, 208-227, 236-258, 262-284 and 296-318 637910022042 HMMPfam hit to PF03547, Auxin efflux carrier, score 5.8e-87 637910022043 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022044 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 637910022045 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 637910022046 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 637910022047 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 637910022048 HMMPfam hit to PF00698, Acyl transferase, score 2.2e-09 637910022049 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910022050 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910022051 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 637910022052 putative dimerization interface [polypeptide binding]; other site 637910022053 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.5e-35 637910022054 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 1.3e-12 637910022055 PS00044 Bacterial regulatory proteins, lysR family signature. 637910022056 Predicted helix-turn-helix motif with score 1181.000, SD 3.21 at aa 24-45, sequence GNIARTAEALDISGVSVHRALH 637910022057 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 637910022058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910022059 Walker A/P-loop; other site 637910022060 ATP binding site [chemical binding]; other site 637910022061 Q-loop/lid; other site 637910022062 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637910022063 ABC transporter signature motif; other site 637910022064 Walker B; other site 637910022065 D-loop; other site 637910022066 ABC transporter; Region: ABC_tran_2; pfam12848 637910022067 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637910022068 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 637910022069 HMMPfam hit to PF00005, ABC transporter related, score 1.6e-44 637910022070 PS00211 ABC transporters family signature. 637910022071 PS00017 ATP/GTP-binding site motif A (P-loop). 637910022072 HMMPfam hit to PF00005, ABC transporter related, score 1e-46 637910022073 PS00211 ABC transporters family signature. 637910022074 PS00017 ATP/GTP-binding site motif A (P-loop). 637910022075 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 637910022076 HMMPfam hit to PF02525, Flavodoxin-like fold, score 4.8e-72 637910022077 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 637910022078 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 637910022079 TrkA-N domain; Region: TrkA_N; pfam02254 637910022080 10 transmembrane helices predicted for ROD44681 by TMHMM2.0 at aa 5-24, 29-51, 56-73, 86-108, 113-135, 148-170, 180-202, 223-245, 265-287 and 294-316 637910022081 HMMPfam hit to PF00999, Sodium/hydrogen exchanger, score 1.3e-77 637910022082 HMMPfam hit to PF02254, TrkA-N, score 7.5e-30 637910022083 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 637910022084 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 637910022085 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 637910022086 HMMPfam hit to PF00254, Peptidyl-prolyl cis-trans isomerase, FKBP-type, score 0.0002 637910022087 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 637910022088 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 637910022089 phi X174 lysis protein; Provisional; Region: PRK02793 637910022090 HMMPfam hit to PF04102, SlyX, score 1.8e-38 637910022091 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 637910022092 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 637910022093 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 637910022094 HMMPfam hit to PF01346, Peptidyl-prolyl cis-trans isomerase, FKBP-type, N-terminal, score 1.4e-61 637910022095 HMMPfam hit to PF00254, Peptidyl-prolyl cis-trans isomerase, FKBP-type, score 1.3e-46 637910022096 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 637910022097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 637910022098 YheO-like PAS domain; Region: PAS_6; pfam08348 637910022099 HTH domain; Region: HTH_22; pfam13309 637910022100 HMMPfam hit to PF08348, YheO-like, score 7.2e-59 637910022101 Predicted helix-turn-helix motif with score 1347.000, SD 3.77 at aa 207-228, sequence DAINQVADRLNISKHTVYLYIR 637910022102 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 637910022103 HMMPfam hit to PF02635, DsrE-like protein, score 7e-57 637910022104 sulfur relay protein TusC; Validated; Region: PRK00211 637910022105 HMMPfam hit to PF02635, DsrE-like protein, score 9.4e-37 637910022106 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 637910022107 HMMPfam hit to PF04077, DsrH like protein, score 7.7e-34 637910022108 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 637910022109 S17 interaction site [polypeptide binding]; other site 637910022110 S8 interaction site; other site 637910022111 16S rRNA interaction site [nucleotide binding]; other site 637910022112 streptomycin interaction site [chemical binding]; other site 637910022113 23S rRNA interaction site [nucleotide binding]; other site 637910022114 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 637910022115 HMMPfam hit to PF00164, Ribosomal protein S12/S23, score 3.4e-75 637910022116 PS00055 Ribosomal protein S12 signature. 637910022117 30S ribosomal protein S7; Validated; Region: PRK05302 637910022118 HMMPfam hit to PF00177, Ribosomal protein S7, score 1.1e-87 637910022119 PS00052 Ribosomal protein S7 signature. 637910022120 elongation factor G; Reviewed; Region: PRK00007 637910022121 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 637910022122 G1 box; other site 637910022123 putative GEF interaction site [polypeptide binding]; other site 637910022124 GTP/Mg2+ binding site [chemical binding]; other site 637910022125 Switch I region; other site 637910022126 G2 box; other site 637910022127 G3 box; other site 637910022128 Switch II region; other site 637910022129 G4 box; other site 637910022130 G5 box; other site 637910022131 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 637910022132 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 637910022133 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 637910022134 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 1.6e-111 637910022135 PS00017 ATP/GTP-binding site motif A (P-loop). 637910022136 PS00301 GTP-binding elongation factors signature. 637910022137 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 3.5e-20 637910022138 HMMPfam hit to PF03764, Translation elongation factor EFG/EF2, domain IV, score 7.4e-67 637910022139 HMMPfam hit to PF00679, Translation elongation factor EFG/EF2, C-terminal, score 1.6e-46 637910022140 elongation factor Tu; Reviewed; Region: PRK00049 637910022141 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 637910022142 G1 box; other site 637910022143 GEF interaction site [polypeptide binding]; other site 637910022144 GTP/Mg2+ binding site [chemical binding]; other site 637910022145 Switch I region; other site 637910022146 G2 box; other site 637910022147 G3 box; other site 637910022148 Switch II region; other site 637910022149 G4 box; other site 637910022150 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 637910022151 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 637910022152 Antibiotic Binding Site [chemical binding]; other site 637910022153 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 4.1e-96 637910022154 PS00017 ATP/GTP-binding site motif A (P-loop). 637910022155 PS00301 GTP-binding elongation factors signature. 637910022156 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 1.3e-25 637910022157 HMMPfam hit to PF03143, Translation elongation factor EFTu/EF1A, C-terminal, score 1e-60 637910022158 Chitin-binding domain type 3; Region: ChtBD3; smart00495 637910022159 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 637910022160 aromatic chitin/cellulose binding site residues [chemical binding]; other site 637910022161 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 637910022162 active site 637910022163 HMMPfam hit to PF02839, Carbohydrate-binding family V/XII, score 0.00028 637910022164 HMMPfam hit to PF02839, Carbohydrate-binding family V/XII, score 1.3e-09 637910022165 HMMPfam hit to PF02839, Carbohydrate-binding family V/XII, score 0.00096 637910022166 HMMPfam hit to PF00704, Glycoside hydrolase, family 18, catalytic domain, score 8.8e-05 637910022167 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022168 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 637910022169 Glyco_18 domain; Region: Glyco_18; smart00636 637910022170 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 637910022171 active site 637910022172 HMMPfam hit to PF00704, Glycoside hydrolase, family 18, catalytic domain, score 1.5e-97 637910022173 PS01095 Chitinases family 18 active site. 637910022174 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 637910022175 Glyco_18 domain; Region: Glyco_18; smart00636 637910022176 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 637910022177 active site 637910022178 HMMPfam hit to PF00704, Glycoside hydrolase, family 18, catalytic domain, score 3.8e-98 637910022179 PS01095 Chitinases family 18 active site. 637910022180 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 637910022181 Glyco_18 domain; Region: Glyco_18; smart00636 637910022182 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 637910022183 active site 637910022184 HMMPfam hit to PF00704, Glycoside hydrolase, family 18, catalytic domain, score 5e-99 637910022185 PS01095 Chitinases family 18 active site. 637910022186 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022187 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 637910022188 HMMPfam hit to PF04324, BFD-like [2Fe-2S]-binding region, score 1.4e-19 637910022189 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 637910022190 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 637910022191 heme binding site [chemical binding]; other site 637910022192 ferroxidase pore; other site 637910022193 ferroxidase diiron center [ion binding]; other site 637910022194 HMMPfam hit to PF00210, Ferritin and Dps, score 6.2e-51 637910022195 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 637910022196 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 637910022197 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 637910022198 5 transmembrane helices predicted for ROD44871 by TMHMM2.0 at aa 7-29, 81-103, 110-132, 205-227 and 234-256 637910022199 HMMPfam hit to PF01478, Peptidase A24A, prepilin type IV, score 4.5e-24 637910022200 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022201 HMMPfam hit to PF06750, Peptidase A24A, N-terminal, score 1.3e-28 637910022202 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 637910022203 HMMPfam hit to PF04612, General secretion pathway M protein, score 4e-09 637910022204 1 transmembrane helix predicted for ROD44881 by TMHMM2.0 at aa 19-41 637910022205 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022206 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 637910022207 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 637910022208 GspL periplasmic domain; Region: GspL_C; cl14909 637910022209 HMMPfam hit to PF05134, General secretion pathway L, score 1.9e-26 637910022210 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 637910022211 HMMPfam hit to PF03934, General secretion pathway protein K, score 1.5e-72 637910022212 1 transmembrane helix predicted for ROD44901 by TMHMM2.0 at aa 7-29 637910022213 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 637910022214 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 637910022215 1 transmembrane helix predicted for ROD44911 by TMHMM2.0 at aa 13-35 637910022216 HMMPfam hit to PF07963, Prepilin-type cleavage/methylation, N-terminal, score 2.1e-05 637910022217 PS00409 Prokaryotic N-terminal methylation site. 637910022218 HMMPfam hit to PF02501, Bacterial type II secretion system protein I/J, score 0.047 637910022219 1 transmembrane helix predicted for ROD44921 by TMHMM2.0 at aa 7-29 637910022220 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 637910022221 Type II transport protein GspH; Region: GspH; pfam12019 637910022222 1 transmembrane helix predicted for ROD44931 by TMHMM2.0 at aa 7-29 637910022223 HMMPfam hit to PF07963, Prepilin-type cleavage/methylation, N-terminal, score 0.00015 637910022224 PS00409 Prokaryotic N-terminal methylation site. 637910022225 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 637910022226 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 637910022227 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 637910022228 HMMPfam hit to PF08334, Bacterial type II secretion system protein G, score 2.2e-61 637910022229 1 transmembrane helix predicted for ROD44941 by TMHMM2.0 at aa 15-37 637910022230 HMMPfam hit to PF07963, Prepilin-type cleavage/methylation, N-terminal, score 2.2e-08 637910022231 type II secretion system protein F; Region: GspF; TIGR02120 637910022232 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 637910022233 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 637910022234 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 2.4e-20 637910022235 3 transmembrane helices predicted for ROD44951 by TMHMM2.0 at aa 165-187, 215-237 and 363-385 637910022236 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 5.3e-25 637910022237 PS00874 Bacterial type II secretion system protein F signature. 637910022238 type II secretion system protein E; Region: type_II_gspE; TIGR02533 637910022239 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 637910022240 Walker A motif; other site 637910022241 ATP binding site [chemical binding]; other site 637910022242 Walker B motif; other site 637910022243 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 1.5e-142 637910022244 PS00662 Bacterial type II secretion system protein E signature. 637910022245 PS00017 ATP/GTP-binding site motif A (P-loop). 637910022246 type II secretion system protein D; Region: type_II_gspD; TIGR02517 637910022247 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 637910022248 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 637910022249 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 637910022250 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 637910022251 HMMPfam hit to PF00263, Bacterial type II and III secretion system protein, score 1.9e-99 637910022252 PS00875 Bacterial type II secretion system protein D signature. 637910022253 HMMPfam hit to PF03958, NolW-like, score 1.5e-11 637910022254 HMMPfam hit to PF03958, NolW-like, score 9.5e-14 637910022255 HMMPfam hit to PF03958, NolW-like, score 1.2e-09 637910022256 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 637910022257 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 637910022258 1 transmembrane helix predicted for ROD44981 by TMHMM2.0 at aa 15-37 637910022259 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 637910022260 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 637910022261 PS00017 ATP/GTP-binding site motif A (P-loop). 637910022262 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022263 HMMPfam hit to PF01471, Peptidoglycan binding-like, score 2.5e-07 637910022264 protein secretion protein GspB; Provisional; Region: PRK09697 637910022265 1 transmembrane helix predicted for ROD45001 by TMHMM2.0 at aa 28-50 637910022266 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022267 PS00177 DNA topoisomerase II signature. 637910022268 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 637910022269 HMMPfam hit to PF00338, Ribosomal protein S10, score 5.8e-62 637910022270 PS00361 Ribosomal protein S10 signature. 637910022271 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 637910022272 HMMPfam hit to PF00297, Ribosomal protein L3, score 3.6e-106 637910022273 PS00474 Ribosomal protein L3 signature. 637910022274 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 637910022275 HMMPfam hit to PF00573, Ribosomal protein L4/L1e, score 1.6e-55 637910022276 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 637910022277 PS00430 TonB-dependent receptor proteins signature 1. 637910022278 HMMPfam hit to PF00276, Ribosomal protein L25/L23, score 2.3e-44 637910022279 PS00050 Ribosomal protein L23 signature. 637910022280 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 637910022281 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 637910022282 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 637910022283 HMMPfam hit to PF00181, Ribosomal protein L2, score 1.8e-47 637910022284 HMMPfam hit to PF03947, Ribosomal protein L2, score 5.4e-83 637910022285 PS00467 Ribosomal protein L2 signature. 637910022286 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 637910022287 HMMPfam hit to PF00203, Ribosomal protein S19/S15, score 3.9e-54 637910022288 PS00323 Ribosomal protein S19 signature. 637910022289 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 637910022290 protein-rRNA interface [nucleotide binding]; other site 637910022291 putative translocon binding site; other site 637910022292 HMMPfam hit to PF00237, Ribosomal protein L22/L17, score 3.2e-60 637910022293 PS00464 Ribosomal protein L22 signature. 637910022294 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 637910022295 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 637910022296 G-X-X-G motif; other site 637910022297 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 637910022298 HMMPfam hit to PF00417, Ribosomal protein S3, N-terminal, score 5.8e-29 637910022299 HMMPfam hit to PF07650, K Homology, type 2, score 1.9e-19 637910022300 HMMPfam hit to PF00189, Ribosomal protein S3, C-terminal, score 7.4e-54 637910022301 PS00548 Ribosomal protein S3 signature. 637910022302 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 637910022303 23S rRNA interface [nucleotide binding]; other site 637910022304 5S rRNA interface [nucleotide binding]; other site 637910022305 putative antibiotic binding site [chemical binding]; other site 637910022306 L25 interface [polypeptide binding]; other site 637910022307 L27 interface [polypeptide binding]; other site 637910022308 HMMPfam hit to PF00252, Ribosomal protein L16, score 1.6e-92 637910022309 PS00586 Ribosomal protein L16 signature 1. 637910022310 PS00701 Ribosomal protein L16 signature 2. 637910022311 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 637910022312 23S rRNA interface [nucleotide binding]; other site 637910022313 putative translocon interaction site; other site 637910022314 signal recognition particle (SRP54) interaction site; other site 637910022315 L23 interface [polypeptide binding]; other site 637910022316 trigger factor interaction site; other site 637910022317 HMMPfam hit to PF00831, Ribosomal protein L29, score 2.6e-28 637910022318 PS00579 Ribosomal protein L29 signature. 637910022319 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 637910022320 HMMPfam hit to PF00366, Ribosomal protein S17, score 4.5e-42 637910022321 PS00056 Ribosomal protein S17 signature. 637910022322 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 637910022323 HMMPfam hit to PF00238, Ribosomal protein L14b/L23e, score 1e-80 637910022324 PS00049 Ribosomal protein L14 signature. 637910022325 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 637910022326 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 637910022327 RNA binding site [nucleotide binding]; other site 637910022328 HMMPfam hit to PF00467, KOW, score 6.9e-07 637910022329 PS01108 Ribosomal protein L24 signature. 637910022330 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 637910022331 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 637910022332 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 637910022333 HMMPfam hit to PF00281, Ribosomal protein L5, score 6.6e-33 637910022334 PS00358 Ribosomal protein L5 signature. 637910022335 HMMPfam hit to PF00673, Ribosomal protein L5, score 1.6e-58 637910022336 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 637910022337 HMMPfam hit to PF00253, Ribosomal protein S14, score 1.1e-26 637910022338 PS00527 Ribosomal protein S14 signature. 637910022339 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 637910022340 HMMPfam hit to PF00410, Ribosomal protein S8, score 1.7e-72 637910022341 PS00053 Ribosomal protein S8 signature. 637910022342 PS00294 Prenyl group binding site (CAAX box). 637910022343 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 637910022344 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 637910022345 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 637910022346 HMMPfam hit to PF00347, Ribosomal protein L6, score 3.3e-21 637910022347 HMMPfam hit to PF00347, Ribosomal protein L6, score 1.9e-30 637910022348 PS00525 Ribosomal protein L6 signature 1. 637910022349 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 637910022350 23S rRNA interface [nucleotide binding]; other site 637910022351 5S rRNA interface [nucleotide binding]; other site 637910022352 L27 interface [polypeptide binding]; other site 637910022353 L5 interface [polypeptide binding]; other site 637910022354 HMMPfam hit to PF00861, Ribosomal protein L18/L5, score 2.1e-52 637910022355 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 637910022356 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 637910022357 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 637910022358 HMMPfam hit to PF00333, Ribosomal protein S5, N-terminal, score 4.8e-41 637910022359 PS00585 Ribosomal protein S5 signature. 637910022360 HMMPfam hit to PF03719, Ribosomal protein S5, C-terminal, score 5.8e-43 637910022361 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 637910022362 23S rRNA binding site [nucleotide binding]; other site 637910022363 HMMPfam hit to PF00327, Ribosomal protein L30, score 1.1e-23 637910022364 PS00634 Ribosomal protein L30 signature. 637910022365 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 637910022366 HMMPfam hit to PF01305, Ribosomal protein L15, score 1.3e-56 637910022367 HMMPfam hit to PF00256, Ribosomal protein L15, score 1.9e-10 637910022368 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 637910022369 SecY translocase; Region: SecY; pfam00344 637910022370 10 transmembrane helices predicted for ROD45221 by TMHMM2.0 at aa 22-44, 76-98, 119-138, 153-175, 182-204, 215-237, 274-296, 316-338, 373-392 and 397-414 637910022371 HMMPfam hit to PF00344, SecY protein, score 7.2e-212 637910022372 PS00755 Protein secY signature 1. 637910022373 PS00756 Protein secY signature 2. 637910022374 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 637910022375 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 637910022376 HMMPfam hit to PF00444, Ribosomal protein L36, score 6e-16 637910022377 PS00828 Ribosomal protein L36 signature. 637910022378 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 637910022379 30S ribosomal protein S13; Region: bact_S13; TIGR03631 637910022380 HMMPfam hit to PF00416, Ribosomal protein S13, score 6.6e-63 637910022381 PS00061 Short-chain dehydrogenases/reductases family signature. 637910022382 PS00646 Ribosomal protein S13 signature. 637910022383 30S ribosomal protein S11; Validated; Region: PRK05309 637910022384 HMMPfam hit to PF00411, Ribosomal protein S11, score 4.5e-76 637910022385 PS00054 Ribosomal protein S11 signature. 637910022386 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 637910022387 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 637910022388 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 637910022389 RNA binding surface [nucleotide binding]; other site 637910022390 HMMPfam hit to PF00163, Ribosomal protein S4, score 1.1e-37 637910022391 PS00632 Ribosomal protein S4 signature. 637910022392 HMMPfam hit to PF01479, RNA-binding S4, score 9.2e-22 637910022393 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 637910022394 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 637910022395 alphaNTD homodimer interface [polypeptide binding]; other site 637910022396 alphaNTD - beta interaction site [polypeptide binding]; other site 637910022397 alphaNTD - beta' interaction site [polypeptide binding]; other site 637910022398 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 637910022399 HMMPfam hit to PF01193, RNA polymerase, dimerisation, score 8.2e-24 637910022400 HMMPfam hit to PF01000, RNA polymerase, insert, score 2.1e-58 637910022401 HMMPfam hit to PF03118, RNA polymerase, subunit alpha, C-terminal, score 1.9e-35 637910022402 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 637910022403 HMMPfam hit to PF01196, Ribosomal protein L17, score 6.2e-67 637910022404 PS01167 Ribosomal protein L17 signature. 637910022405 hypothetical protein; Provisional; Region: PRK10203 637910022406 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 637910022407 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 637910022408 DNA binding residues [nucleotide binding] 637910022409 dimer interface [polypeptide binding]; other site 637910022410 metal binding site [ion binding]; metal-binding site 637910022411 Predicted helix-turn-helix motif with score 1729.000, SD 5.08 at aa 2-23, sequence YRIGEIAKLAEVTPDTIRYYEK 637910022412 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 5.9e-09 637910022413 PS00552 Bacterial regulatory proteins, merR family signature. 637910022414 HMMPfam hit to PF09278, Transcription regulator MerR, DNA binding, score 1.2e-24 637910022415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 637910022416 HMMPfam hit to PF03889, Protein of unknown function DUF331, score 9.7e-30 637910022417 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 637910022418 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 637910022419 HMMPfam hit to PF01741, Large-conductance mechanosensitive channel, score 5.3e-90 637910022420 2 transmembrane helices predicted for ROD45311 by TMHMM2.0 at aa 20-42 and 77-99 637910022421 PS01327 Large-conductance mechanosensitive channels mscL family signature. 637910022422 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 637910022423 TrkA-N domain; Region: TrkA_N; pfam02254 637910022424 TrkA-C domain; Region: TrkA_C; pfam02080 637910022425 TrkA-N domain; Region: TrkA_N; pfam02254 637910022426 TrkA-C domain; Region: TrkA_C; pfam02080 637910022427 HMMPfam hit to PF02080, TrkA-C, score 4.1e-11 637910022428 HMMPfam hit to PF02254, TrkA-N, score 2.3e-35 637910022429 HMMPfam hit to PF02080, TrkA-C, score 1.6e-11 637910022430 HMMPfam hit to PF02254, TrkA-N, score 5.9e-36 637910022431 16S rRNA methyltransferase B; Provisional; Region: PRK10901 637910022432 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 637910022433 putative RNA binding site [nucleotide binding]; other site 637910022434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910022435 S-adenosylmethionine binding site [chemical binding]; other site 637910022436 HMMPfam hit to PF01189, Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, score 1.7e-134 637910022437 PS01153 NOL1/NOP2/sun family signature. 637910022438 HMMPfam hit to PF01029, NusB/RsmB/TIM44, score 3.7e-44 637910022439 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 637910022440 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 637910022441 putative active site [active] 637910022442 substrate binding site [chemical binding]; other site 637910022443 putative cosubstrate binding site; other site 637910022444 catalytic site [active] 637910022445 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 637910022446 substrate binding site [chemical binding]; other site 637910022447 HMMPfam hit to PF02911, Formyl transferase, C-terminal, score 2.8e-49 637910022448 HMMPfam hit to PF00551, Formyl transferase, N-terminal, score 3.8e-82 637910022449 PS00373 Phosphoribosylglycinamide formyltransferase active site. 637910022450 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 637910022451 active site 637910022452 catalytic residues [active] 637910022453 metal binding site [ion binding]; metal-binding site 637910022454 HMMPfam hit to PF01327, Formylmethionine deformylase, score 1.8e-89 637910022455 hypothetical protein; Provisional; Region: PRK10736 637910022456 DNA protecting protein DprA; Region: dprA; TIGR00732 637910022457 HMMPfam hit to PF02481, SMF protein, score 2.4e-108 637910022458 hypothetical protein; Validated; Region: PRK03430 637910022459 HMMPfam hit to PF04361, Protein of unknown function DUF494, score 1.9e-121 637910022460 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 637910022461 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 637910022462 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 637910022463 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 637910022464 HMMPfam hit to PF01396, DNA topoisomerase, type IA, zn finger, score 4.8e-16 637910022465 HMMPfam hit to PF01396, DNA topoisomerase, type IA, zn finger, score 7.4e-17 637910022466 HMMPfam hit to PF01396, DNA topoisomerase, type IA, zn finger, score 2.5e-17 637910022467 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 637910022468 HMMPfam hit to PF01300, SUA5/yciO/yrdC, N-terminal, score 5.5e-52 637910022469 PS01147 SUA5/yciO/yrdC family signature. 637910022470 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 637910022471 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 637910022472 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 637910022473 shikimate binding site; other site 637910022474 NAD(P) binding site [chemical binding]; other site 637910022475 HMMPfam hit to PF08501, Shikimate dehydrogenase substrate-binding, N-terminal, score 2.5e-30 637910022476 HMMPfam hit to PF01488, Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase, score 2.3e-29 637910022477 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 637910022478 HMMPfam hit to PF07369, Protein of unknown function DUF1488, score 3.9e-50 637910022479 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 637910022480 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 637910022481 trimer interface [polypeptide binding]; other site 637910022482 putative metal binding site [ion binding]; other site 637910022483 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 5.7 637910022484 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.9 637910022485 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 15 637910022486 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 19 637910022487 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 637910022488 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 637910022489 Walker A/P-loop; other site 637910022490 ATP binding site [chemical binding]; other site 637910022491 Q-loop/lid; other site 637910022492 ABC transporter signature motif; other site 637910022493 Walker B; other site 637910022494 D-loop; other site 637910022495 H-loop/switch region; other site 637910022496 HMMPfam hit to PF00005, ABC transporter related, score 8.7e-67 637910022497 PS00211 ABC transporters family signature. 637910022498 PS00017 ATP/GTP-binding site motif A (P-loop). 637910022499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910022500 dimer interface [polypeptide binding]; other site 637910022501 conserved gate region; other site 637910022502 putative PBP binding loops; other site 637910022503 ABC-ATPase subunit interface; other site 637910022504 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.4e-33 637910022505 8 transmembrane helices predicted for ROD45441 by TMHMM2.0 at aa 29-51, 98-120, 127-149, 159-181, 202-224, 279-301, 306-324 and 328-350 637910022506 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 637910022507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910022508 conserved gate region; other site 637910022509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 637910022510 dimer interface [polypeptide binding]; other site 637910022511 conserved gate region; other site 637910022512 putative PBP binding loops; other site 637910022513 ABC-ATPase subunit interface; other site 637910022514 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.4e-22 637910022515 8 transmembrane helices predicted for ROD45451 by TMHMM2.0 at aa 21-40, 90-112, 125-147, 181-203, 216-235, 255-277, 334-353 and 363-385 637910022516 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910022517 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 637910022518 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 637910022519 substrate binding pocket [chemical binding]; other site 637910022520 membrane-bound complex binding site; other site 637910022521 hinge residues; other site 637910022522 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 3.5e-16 637910022523 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 637910022524 1 transmembrane helix predicted for ROD45471 by TMHMM2.0 at aa 50-72 637910022525 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022526 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 637910022527 HMMPfam hit to PF00873, Acriflavin resistance protein, score 0 637910022528 12 transmembrane helices predicted for ROD45481 by TMHMM2.0 at aa 11-33, 337-359, 366-388, 392-414, 438-460, 470-492, 541-563, 872-891, 898-920, 925-947, 974-996 and 1006-1028 637910022529 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 637910022530 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637910022531 HlyD family secretion protein; Region: HlyD_3; pfam13437 637910022532 HMMPfam hit to PF00529, Secretion protein HlyD, score 4e-99 637910022533 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022534 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 637910022535 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910022536 HMMPfam hit to PF01609, Transposase, IS4-like, score 9.3e-30 637910022537 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 637910022538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 637910022539 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 637910022540 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 2e-19 637910022541 PS01081 Bacterial regulatory proteins, tetR family signature. 637910022542 Predicted helix-turn-helix motif with score 1722.000, SD 5.05 at aa 32-53, sequence TTLNDIADAAQVTRGAIYWHFH 637910022543 HMMPfam hit to PF08361, Transcriptional regulator, MAATS, C-terminal, score 4.9e-62 637910022544 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 637910022545 1 transmembrane helix predicted for ROD45512 by TMHMM2.0 at aa 7-29 637910022546 putative methyltransferase; Provisional; Region: PRK11524 637910022547 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 637910022548 HMMPfam hit to PF01555, DNA methylase N-4/N-6, score 4.1e-80 637910022549 PS00092 N-6 Adenine-specific DNA methylases signature. 637910022550 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 637910022551 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 637910022552 HMMPfam hit to PF02954, Helix-turn-helix, Fis-type, score 1.1e-14 637910022553 Predicted helix-turn-helix motif with score 1824.000, SD 5.40 at aa 72-93, sequence GNQTRAALMMGINRGTLRKKLK 637910022554 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 637910022555 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 637910022556 FMN binding site [chemical binding]; other site 637910022557 active site 637910022558 catalytic residues [active] 637910022559 substrate binding site [chemical binding]; other site 637910022560 HMMPfam hit to PF01207, Dihydrouridine synthase, DuS, score 3.3e-161 637910022561 PS01136 Uncharacterized protein family UPF0034 signature. 637910022562 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 637910022563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 637910022564 HMMPfam hit to PF06325, Ribosomal L11 methyltransferase, score 5.9e-176 637910022565 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 637910022566 Na binding site [ion binding]; other site 637910022567 13 transmembrane helices predicted for ROD45561 by TMHMM2.0 at aa 5-24, 37-59, 72-94, 123-145, 160-182, 189-211, 233-255, 268-290, 319-341, 369-386, 391-413, 420-442 and 447-466 637910022568 PS00457 Sodium:solute symporter family signature 2. 637910022569 HMMPfam hit to PF00474, Na+/solute symporter, score 3.4e-199 637910022570 PS00456 Sodium:solute symporter family signature 1. 637910022571 hypothetical protein; Provisional; Region: PRK10633 637910022572 HMMPfam hit to PF06196, Protein of unknown function DUF997, score 6.2e-47 637910022573 2 transmembrane helices predicted for ROD45571 by TMHMM2.0 at aa 13-35 and 45-62 637910022574 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 637910022575 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 637910022576 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 637910022577 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 637910022578 HMMPfam hit to PF02785, Biotin carboxylase, C-terminal, score 9.7e-66 637910022579 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 3.2e-130 637910022580 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 637910022581 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 637910022582 HMMPfam hit to PF00289, Carbamoyl-phosphate synthetase large chain, N-terminal, score 1.3e-56 637910022583 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 637910022584 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 637910022585 carboxyltransferase (CT) interaction site; other site 637910022586 biotinylation site [posttranslational modification]; other site 637910022587 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 3e-35 637910022588 PS00188 Biotin-requiring enzymes attachment site. 637910022589 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 637910022590 6 transmembrane helices predicted for ROD45611 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 117-139, 151-168 and 172-189 637910022591 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022592 HMMPfam hit to PF01794, Ferric reductase-like transmembrane component, N-terminal, score 2.8e-29 637910022593 TMAO/DMSO reductase; Reviewed; Region: PRK05363 637910022594 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 637910022595 Moco binding site; other site 637910022596 metal coordination site [ion binding]; other site 637910022597 HMMPfam hit to PF00174, Oxidoreductase, molybdopterin binding, score 1.5e-67 637910022598 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 637910022599 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 637910022600 NADP binding site [chemical binding]; other site 637910022601 dimer interface [polypeptide binding]; other site 637910022602 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 7.7e-14 637910022603 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 2.4e-12 637910022604 regulatory protein CsrD; Provisional; Region: PRK11059 637910022605 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637910022606 metal binding site [ion binding]; metal-binding site 637910022607 active site 637910022608 I-site; other site 637910022609 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637910022610 2 transmembrane helices predicted for ROD45641 by TMHMM2.0 at aa 10-32 and 136-158 637910022611 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022612 HMMPfam hit to PF00990, GGDEF, score 1.4e-32 637910022613 HMMPfam hit to PF00563, EAL, score 6.6e-62 637910022614 rod shape-determining protein MreB; Provisional; Region: PRK13927 637910022615 MreB and similar proteins; Region: MreB_like; cd10225 637910022616 nucleotide binding site [chemical binding]; other site 637910022617 Mg binding site [ion binding]; other site 637910022618 putative protofilament interaction site [polypeptide binding]; other site 637910022619 RodZ interaction site [polypeptide binding]; other site 637910022620 HMMPfam hit to PF06723, Cell shape determining protein MreB/Mrl, score 7.8e-239 637910022621 rod shape-determining protein MreC; Region: mreC; TIGR00219 637910022622 rod shape-determining protein MreC; Region: MreC; pfam04085 637910022623 1 transmembrane helix predicted for ROD45661 by TMHMM2.0 at aa 13-35 637910022624 HMMPfam hit to PF04085, Rod shape-determining protein MreC, score 1.3e-72 637910022625 rod shape-determining protein MreD; Provisional; Region: PRK11060 637910022626 HMMPfam hit to PF04093, Rod shape-determining protein MreD, score 9.3e-61 637910022627 5 transmembrane helices predicted for ROD45671 by TMHMM2.0 at aa 10-24, 31-53, 68-90, 97-119 and 134-151 637910022628 Maf-like protein; Region: Maf; pfam02545 637910022629 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 637910022630 active site 637910022631 dimer interface [polypeptide binding]; other site 637910022632 HMMPfam hit to PF02545, Maf-like protein, score 1.8e-98 637910022633 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022634 ribonuclease G; Provisional; Region: PRK11712 637910022635 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 637910022636 homodimer interface [polypeptide binding]; other site 637910022637 oligonucleotide binding site [chemical binding]; other site 637910022638 HMMPfam hit to PF00575, S1, RNA binding, score 1.2e-19 637910022639 hypothetical protein; Provisional; Region: PRK10899 637910022640 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 637910022641 1 transmembrane helix predicted for ROD45701 by TMHMM2.0 at aa 7-29 637910022642 protease TldD; Provisional; Region: tldD; PRK10735 637910022643 HMMPfam hit to PF01523, Peptidase U62, modulator of DNA gyrase, score 9e-111 637910022644 transcriptional regulator; Provisional; Region: PRK10632 637910022645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910022646 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 637910022647 putative effector binding pocket; other site 637910022648 dimerization interface [polypeptide binding]; other site 637910022649 HMMPfam hit to PF03466, LysR, substrate-binding, score 3.5e-45 637910022650 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 6.3e-18 637910022651 PS00044 Bacterial regulatory proteins, lysR family signature. 637910022652 Predicted helix-turn-helix motif with score 1464.000, SD 4.17 at aa 17-38, sequence GSFTAAARQLQMSVSSISQTVA 637910022653 efflux system membrane protein; Provisional; Region: PRK11594 637910022654 2 transmembrane helices predicted for ROD45731 by TMHMM2.0 at aa 13-35 and 55-74 637910022655 HMMPfam hit to PF07869, Protein of unknown function DUF1656, score 1.6e-24 637910022656 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 637910022657 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637910022658 HlyD family secretion protein; Region: HlyD_3; pfam13437 637910022659 1 transmembrane helix predicted for ROD45741 by TMHMM2.0 at aa 12-31 637910022660 HMMPfam hit to PF00529, Secretion protein HlyD, score 1.8e-43 637910022661 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 637910022662 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 637910022663 Transcription factor Vhr1; Region: Vhr1; pfam04001 637910022664 10 transmembrane helices predicted for ROD45751 by TMHMM2.0 at aa 13-33, 38-60, 67-89, 93-112, 119-136, 151-168, 366-388, 403-425, 432-449 and 481-503 637910022665 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022666 HMMPfam hit to PF04632, Fusaric acid resistance protein conserved region, score 1.7e-48 637910022667 Predicted helix-turn-helix motif with score 974.000, SD 2.50 at aa 609-630, sequence RYFAQLLDELDIYQEKLRIWEA 637910022668 succinic semialdehyde dehydrogenase; Region: PLN02278 637910022669 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 637910022670 tetramerization interface [polypeptide binding]; other site 637910022671 NAD(P) binding site [chemical binding]; other site 637910022672 catalytic residues [active] 637910022673 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 1.7e-221 637910022674 PS00017 ATP/GTP-binding site motif A (P-loop). 637910022675 PS00687 Aldehyde dehydrogenases glutamic acid active site. 637910022676 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 637910022677 RNAase interaction site [polypeptide binding]; other site 637910022678 pseudogene, truncated by two frameshift mutations; Similar to several other genes in Crod including ROD40661 637910022679 HMMPfam hit to PF05593, YD repeat, score 3.6 637910022680 HMMPfam hit to PF05593, YD repeat, score 0.027 637910022681 HMMPfam hit to PF05593, YD repeat, score 0.0037 637910022682 HMMPfam hit to PF05593, YD repeat, score 0.00044 637910022683 HMMPfam hit to PF05593, YD repeat, score 0.0029 637910022684 HMMPfam hit to PF05593, YD repeat, score 0.00021 637910022685 HMMPfam hit to PF05593, YD repeat, score 9.3e-07 637910022686 HMMPfam hit to PF05593, YD repeat, score 0.19 637910022687 HMMPfam hit to PF05593, YD repeat, score 0.00032 637910022688 HMMPfam hit to PF05593, YD repeat, score 0.0065 637910022689 HMMPfam hit to PF05593, YD repeat, score 0.047 637910022690 HMMPfam hit to PF03527, RHS protein, score 7.8e-23 637910022691 HMMPfam hit to PF05593, YD repeat, score 2.1 637910022692 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910022693 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910022694 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910022695 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910022696 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910022697 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910022698 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910022699 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910022700 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910022701 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910022702 Transposase; Region: HTH_Tnp_1; pfam01527 637910022703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910022704 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910022705 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910022706 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 637910022707 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 637910022708 HMMPfam hit to PF00023, Ankyrin, score 2.4e-06 637910022709 HMMPfam hit to PF00023, Ankyrin, score 0.00078 637910022710 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 637910022711 HMMPfam hit to PF07338, Protein of unknown function DUF1471, score 5.7e-53 637910022712 arginine repressor; Provisional; Region: PRK05066 637910022713 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 637910022714 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 637910022715 HMMPfam hit to PF02863, Arginine repressor, score 1e-26 637910022716 HMMPfam hit to PF01316, Arginine repressor, score 5e-33 637910022717 malate dehydrogenase; Provisional; Region: PRK05086 637910022718 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 637910022719 NAD binding site [chemical binding]; other site 637910022720 dimerization interface [polypeptide binding]; other site 637910022721 Substrate binding site [chemical binding]; other site 637910022722 HMMPfam hit to PF00056, Lactate/malate dehydrogenase, score 5e-70 637910022723 PS00068 Malate dehydrogenase active site signature. 637910022724 HMMPfam hit to PF02866, Lactate/malate dehydrogenase, score 2.3e-75 637910022725 serine endoprotease; Provisional; Region: PRK10898 637910022726 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 637910022727 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 637910022728 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 5.3e-17 637910022729 HMMPfam hit to PF00089, Peptidase S1 and S6, chymotrypsin/Hap, score 7.2e-30 637910022730 1 transmembrane helix predicted for ROD45881 by TMHMM2.0 at aa 5-24 637910022731 serine endoprotease; Provisional; Region: PRK10139 637910022732 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 637910022733 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 637910022734 protein binding site [polypeptide binding]; other site 637910022735 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 637910022736 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 1.6e-13 637910022737 HMMPfam hit to PF00595, PDZ/DHR/GLGF, score 2.1e-20 637910022738 HMMPfam hit to PF00089, Peptidase S1 and S6, chymotrypsin/Hap, score 1.6e-20 637910022739 1 transmembrane helix predicted for ROD45891 by TMHMM2.0 at aa 7-29 637910022740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 637910022741 hypothetical protein; Provisional; Region: PRK11677 637910022742 HMMPfam hit to PF06295, Protein of unknown function DUF1043, score 5.8e-84 637910022743 1 transmembrane helix predicted for ROD45901 by TMHMM2.0 at aa 5-24 637910022744 Predicted ATPase [General function prediction only]; Region: COG1485 637910022745 HMMPfam hit to PF03969, AFG1-like ATPase, score 6.8e-221 637910022746 PS00017 ATP/GTP-binding site motif A (P-loop). 637910022747 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 637910022748 23S rRNA interface [nucleotide binding]; other site 637910022749 L3 interface [polypeptide binding]; other site 637910022750 HMMPfam hit to PF00572, Ribosomal protein L13, score 7.2e-88 637910022751 PS00783 Ribosomal protein L13 signature. 637910022752 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 637910022753 HMMPfam hit to PF00380, Ribosomal protein S9, score 8e-77 637910022754 PS00360 Ribosomal protein S9 signature. 637910022755 stringent starvation protein A; Provisional; Region: sspA; PRK09481 637910022756 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 637910022757 C-terminal domain interface [polypeptide binding]; other site 637910022758 putative GSH binding site (G-site) [chemical binding]; other site 637910022759 dimer interface [polypeptide binding]; other site 637910022760 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 637910022761 dimer interface [polypeptide binding]; other site 637910022762 N-terminal domain interface [polypeptide binding]; other site 637910022763 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal, score 5.3e-24 637910022764 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 1.3e-15 637910022765 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 637910022766 HMMPfam hit to PF04386, Stringent starvation protein B, score 4.6e-95 637910022767 transcriptional regulator NanR; Provisional; Region: PRK03837 637910022768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910022769 DNA-binding site [nucleotide binding]; DNA binding site 637910022770 FCD domain; Region: FCD; pfam07729 637910022771 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 1.3e-26 637910022772 PS00043 Bacterial regulatory proteins, gntR family signature. 637910022773 HMMPfam hit to PF07729, GntR, C-terminal, score 7.7e-30 637910022774 N-acetylneuraminate lyase; Provisional; Region: PRK04147 637910022775 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 637910022776 inhibitor site; inhibition site 637910022777 active site 637910022778 dimer interface [polypeptide binding]; other site 637910022779 catalytic residue [active] 637910022780 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase, score 8.6e-148 637910022781 PS00665 Dihydrodipicolinate synthetase signature 1. 637910022782 PS00666 Dihydrodipicolinate synthetase signature 2. 637910022783 putative sialic acid transporter; Provisional; Region: PRK03893 637910022784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910022785 putative substrate translocation pore; other site 637910022786 12 transmembrane helices predicted for ROD45981 by TMHMM2.0 at aa 21-43, 53-72, 92-114, 146-168, 170-189, 224-241, 248-267, 277-299, 316-338, 353-375, 404-426 and 431-453 637910022787 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.9e-37 637910022788 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022789 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022790 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 637910022791 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 637910022792 putative active site cavity [active] 637910022793 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022794 HMMPfam hit to PF04131, N-acetylmannosamine-6-phosphate epimerase, score 1.9e-130 637910022795 N-acetylmannosamine kinase; Provisional; Region: PRK05082 637910022796 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 637910022797 nucleotide binding site [chemical binding]; other site 637910022798 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 637910022799 HMMPfam hit to PF00480, ROK, score 2.2e-67 637910022800 PS01125 ROK family signature. 637910022801 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 637910022802 HMMPfam hit to PF04074, Conserved hypothetical protein CHP00022, score 1.6e-65 637910022803 cytosine deaminase; Provisional; Region: PRK09230 637910022804 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 637910022805 active site 637910022806 HMMPfam hit to PF07969, Amidohydrolase 3, score 8.6e-80 637910022807 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 637910022808 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 637910022809 Na binding site [ion binding]; other site 637910022810 putative substrate binding site [chemical binding]; other site 637910022811 12 transmembrane helices predicted for ROD46031 by TMHMM2.0 at aa 21-43, 53-75, 96-118, 128-150, 152-174, 189-211, 223-245, 255-277, 296-318, 323-345, 358-375 and 380-402 637910022812 HMMPfam hit to PF02133, Permease for cytosine/purines, uracil, thiamine, allantoin, score 1.9e-95 637910022813 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 637910022814 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 637910022815 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 637910022816 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 3.7e-24 637910022817 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 0.0027 637910022818 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022819 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 637910022820 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 637910022821 active site 637910022822 dimer interface [polypeptide binding]; other site 637910022823 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 637910022824 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 637910022825 active site 637910022826 FMN binding site [chemical binding]; other site 637910022827 substrate binding site [chemical binding]; other site 637910022828 3Fe-4S cluster binding site [ion binding]; other site 637910022829 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 637910022830 domain interface; other site 637910022831 HMMPfam hit to PF01493, Glutamate synthase, subunit alpha, C-terminal, score 6e-106 637910022832 HMMPfam hit to PF01645, Glutamate synthase, central-C, score 5.2e-245 637910022833 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022834 HMMPfam hit to PF04898, Glutamate synthase, central-N, score 1.9e-169 637910022835 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 6.3e-234 637910022836 PS00017 ATP/GTP-binding site motif A (P-loop). 637910022837 radical SAM protein, TIGR01212 family; Region: TIGR01212 637910022838 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 637910022839 FeS/SAM binding site; other site 637910022840 HMMPfam hit to PF04055, Radical SAM, score 3.6e-15 637910022841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910022842 D-galactonate transporter; Region: 2A0114; TIGR00893 637910022843 putative substrate translocation pore; other site 637910022844 12 transmembrane helices predicted for ROD46071 by TMHMM2.0 at aa 7-29, 44-66, 73-95, 99-121, 134-156, 161-183, 230-252, 267-289, 306-325, 330-352, 365-387 and 397-415 637910022845 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 2.2e-67 637910022846 putative oxidoreductase; Provisional; Region: PRK10083 637910022847 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 637910022848 putative NAD(P) binding site [chemical binding]; other site 637910022849 catalytic Zn binding site [ion binding]; other site 637910022850 structural Zn binding site [ion binding]; other site 637910022851 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 7.6e-29 637910022852 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 4.5e-52 637910022853 PS00059 Zinc-containing alcohol dehydrogenases signature. 637910022854 mannonate dehydratase; Provisional; Region: PRK03906 637910022855 mannonate dehydratase; Region: uxuA; TIGR00695 637910022856 HMMPfam hit to PF03786, Mannonate dehydratase, score 1.2e-242 637910022857 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 637910022858 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637910022859 putative active site [active] 637910022860 heme pocket [chemical binding]; other site 637910022861 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637910022862 dimer interface [polypeptide binding]; other site 637910022863 phosphorylation site [posttranslational modification] 637910022864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910022865 ATP binding site [chemical binding]; other site 637910022866 Mg2+ binding site [ion binding]; other site 637910022867 G-X-G motif; other site 637910022868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910022869 active site 637910022870 phosphorylation site [posttranslational modification] 637910022871 intermolecular recognition site; other site 637910022872 dimerization interface [polypeptide binding]; other site 637910022873 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 637910022874 putative binding surface; other site 637910022875 active site 637910022876 2 transmembrane helices predicted for ROD46101 by TMHMM2.0 at aa 20-42 and 55-77 637910022877 HMMPfam hit to PF00989, PAS fold, score 3.4e-27 637910022878 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 4.2e-21 637910022879 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 4.3e-41 637910022880 HMMPfam hit to PF00072, Response regulator receiver, score 5.6e-36 637910022881 HMMPfam hit to PF01627, Hpt, score 5.5e-13 637910022882 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 637910022883 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 637910022884 conserved cys residue [active] 637910022885 HMMPfam hit to PF01965, ThiJ/PfpI, score 7.6e-18 637910022886 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 637910022887 Transglycosylase; Region: Transgly; cl17702 637910022888 1 transmembrane helix predicted for ROD46121 by TMHMM2.0 at aa 12-34 637910022889 HMMPfam hit to PF00912, Glycosyl transferase, family 51, score 6.8e-80 637910022890 hypothetical protein; Provisional; Region: PRK10345 637910022891 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 637910022892 dimerization domain swap beta strand [polypeptide binding]; other site 637910022893 regulatory protein interface [polypeptide binding]; other site 637910022894 active site 637910022895 regulatory phosphorylation site [posttranslational modification]; other site 637910022896 HMMPfam hit to PF00381, Phosphotransferase system, phosphocarrier HPr protein, score 2.5e-42 637910022897 PS00589 PTS HPR component serine phosphorylation site signature. 637910022898 PS00369 PTS HPR component histidine phosphorylation site signature. 637910022899 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 637910022900 HMMPfam hit to PF03668, P-loop ATPase protein, score 2e-216 637910022901 PS00017 ATP/GTP-binding site motif A (P-loop). 637910022902 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637910022903 active site 637910022904 phosphorylation site [posttranslational modification] 637910022905 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 6.4e-68 637910022906 PS00372 PTS EIIA domains phosphorylation site signature 2. 637910022907 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 637910022908 30S subunit binding site; other site 637910022909 HMMPfam hit to PF02482, Ribosomal protein S30Ae/sigma 54 modulation protein, score 1.1e-51 637910022910 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 637910022911 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 637910022912 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 637910022913 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 637910022914 HMMPfam hit to PF04552, RNA polymerase sigma factor 54, DNA-binding, score 8.7e-108 637910022915 PS00718 Sigma-54 factors family signature 2. 637910022916 Predicted helix-turn-helix motif with score 1756.000, SD 5.17 at aa 365-386, sequence MVLADIAQAVEMHESTISRVTT 637910022917 PS00717 Sigma-54 factors family signature 1. 637910022918 HMMPfam hit to PF04963, RNA polymerase sigma factor 54, core-binding, score 8.3e-120 637910022919 HMMPfam hit to PF00309, RNA polymerase sigma factor 54, score 1.1e-19 637910022920 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 637910022921 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 637910022922 Walker A/P-loop; other site 637910022923 ATP binding site [chemical binding]; other site 637910022924 Q-loop/lid; other site 637910022925 ABC transporter signature motif; other site 637910022926 Walker B; other site 637910022927 D-loop; other site 637910022928 H-loop/switch region; other site 637910022929 HMMPfam hit to PF00005, ABC transporter related, score 7e-57 637910022930 PS00211 ABC transporters family signature. 637910022931 PS00017 ATP/GTP-binding site motif A (P-loop). 637910022932 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 637910022933 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 637910022934 HMMPfam hit to PF03968, OstA-like protein, score 6.3e-62 637910022935 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 637910022936 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 637910022937 HMMPfam hit to PF06835, Protein of unknown function DUF1239, score 6.4e-61 637910022938 1 transmembrane helix predicted for ROD46211 by TMHMM2.0 at aa 7-25 637910022939 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 637910022940 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 637910022941 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 1.3e-07 637910022942 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 637910022943 putative active site [active] 637910022944 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 637910022945 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 4.1e-08 637910022946 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 3.5e-37 637910022947 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 637910022948 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 637910022949 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 637910022950 8 transmembrane helices predicted for ROD46241 by TMHMM2.0 at aa 27-49, 62-79, 89-108, 129-149, 169-191, 198-220, 230-249 and 261-283 637910022951 HMMPfam hit to PF01699, Sodium/calcium exchanger membrane region, score 1.1e-38 637910022952 HMMPfam hit to PF01699, Sodium/calcium exchanger membrane region, score 4.2e-20 637910022953 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 637910022954 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 637910022955 Walker A/P-loop; other site 637910022956 ATP binding site [chemical binding]; other site 637910022957 Q-loop/lid; other site 637910022958 ABC transporter signature motif; other site 637910022959 Walker B; other site 637910022960 D-loop; other site 637910022961 H-loop/switch region; other site 637910022962 HMMPfam hit to PF00005, ABC transporter related, score 3.2e-53 637910022963 PS00017 ATP/GTP-binding site motif A (P-loop). 637910022964 PS00211 ABC transporters family signature. 637910022965 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 637910022966 conserved hypothetical integral membrane protein; Region: TIGR00056 637910022967 HMMPfam hit to PF02405, Protein of unknown function DUF140, score 1.5e-126 637910022968 5 transmembrane helices predicted for ROD46261 by TMHMM2.0 at aa 48-70, 85-107, 148-170, 197-219 and 239-258 637910022969 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 637910022970 mce related protein; Region: MCE; pfam02470 637910022971 1 transmembrane helix predicted for ROD46271 by TMHMM2.0 at aa 13-35 637910022972 HMMPfam hit to PF02470, Mammalian cell entry related, score 4.6e-25 637910022973 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 637910022974 HMMPfam hit to PF05494, Toluene tolerance, score 1.8e-96 637910022975 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 637910022976 anti sigma factor interaction site; other site 637910022977 regulatory phosphorylation site [posttranslational modification]; other site 637910022978 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 637910022979 HMMPfam hit to PF01722, BolA-like protein, score 2.4e-38 637910022980 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 637910022981 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 637910022982 hinge; other site 637910022983 active site 637910022984 HMMPfam hit to PF00275, 3-phosphoshikimate 1-carboxyvinyltransferase, score 4.3e-191 637910022985 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 637910022986 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 637910022987 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 637910022988 substrate binding pocket [chemical binding]; other site 637910022989 chain length determination region; other site 637910022990 substrate-Mg2+ binding site; other site 637910022991 catalytic residues [active] 637910022992 aspartate-rich region 1; other site 637910022993 active site lid residues [active] 637910022994 aspartate-rich region 2; other site 637910022995 HMMPfam hit to PF00348, Polyprenyl synthetase, score 6.1e-130 637910022996 PS00444 Polyprenyl synthetases signature 2. 637910022997 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910022998 PS00723 Polyprenyl synthetases signature 1. 637910022999 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 637910023000 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 637910023001 HMMPfam hit to PF00829, Ribosomal protein L21, score 1.1e-56 637910023002 PS01169 Ribosomal protein L21 signature. 637910023003 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 637910023004 HMMPfam hit to PF01016, Ribosomal protein L27, score 1.8e-57 637910023005 PS00831 Ribosomal protein L27 signature. 637910023006 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 637910023007 EamA-like transporter family; Region: EamA; pfam00892 637910023008 EamA-like transporter family; Region: EamA; pfam00892 637910023009 10 transmembrane helices predicted for ROD46361 by TMHMM2.0 at aa 7-26, 36-58, 71-93, 103-120, 129-151, 155-177, 190-212, 217-239, 246-268 and 278-300 637910023010 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 1.1e-28 637910023011 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 4.9e-15 637910023012 GTPase CgtA; Reviewed; Region: obgE; PRK12298 637910023013 GTP1/OBG; Region: GTP1_OBG; pfam01018 637910023014 Obg GTPase; Region: Obg; cd01898 637910023015 G1 box; other site 637910023016 GTP/Mg2+ binding site [chemical binding]; other site 637910023017 Switch I region; other site 637910023018 G2 box; other site 637910023019 G3 box; other site 637910023020 Switch II region; other site 637910023021 G4 box; other site 637910023022 G5 box; other site 637910023023 HMMPfam hit to PF01018, GTP1/OBG subdomain, score 1.7e-104 637910023024 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 2.9e-38 637910023025 PS00017 ATP/GTP-binding site motif A (P-loop). 637910023026 PS00905 GTP1/OBG family signature. 637910023027 phosphoglycerol transferase I; Provisional; Region: PRK03776 637910023028 4 transmembrane helices predicted for ROD46381 by TMHMM2.0 at aa 5-24, 31-53, 81-103 and 116-138 637910023029 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023030 HMMPfam hit to PF00884, Sulphatase, score 1.1e-10 637910023031 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 637910023032 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 637910023033 HMMPfam hit to PF02113, Peptidase S13, D-Ala-D-Ala carboxypeptidase C, score 3.6e-211 637910023034 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 637910023035 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 637910023036 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 637910023037 HMMPfam hit to PF03449, Transcription elongation factor, GreA/GreB region, prokaryotic, score 2.8e-46 637910023038 PS00829 Prokaryotic transcription elongation factors signature 1. 637910023039 HMMPfam hit to PF01272, Transcription elongation factor, GreA/GreB region, prokaryotic, score 3e-44 637910023040 PS00830 Prokaryotic transcription elongation factors signature 2. 637910023041 RNA-binding protein YhbY; Provisional; Region: PRK10343 637910023042 HMMPfam hit to PF01985, CRS1/YhbY, score 5.3e-38 637910023043 PS01301 Uncharacterized protein family UPF0044 signature. 637910023044 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 637910023045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910023046 S-adenosylmethionine binding site [chemical binding]; other site 637910023047 HMMPfam hit to PF01728, Ribosomal RNA methyltransferase RrmJ/FtsJ, score 1.6e-81 637910023048 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 637910023049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910023050 Walker A motif; other site 637910023051 ATP binding site [chemical binding]; other site 637910023052 Walker B motif; other site 637910023053 arginine finger; other site 637910023054 Peptidase family M41; Region: Peptidase_M41; pfam01434 637910023055 2 transmembrane helices predicted for ROD46431 by TMHMM2.0 at aa 5-24 and 97-119 637910023056 HMMPfam hit to PF06480, Peptidase M41, FtsH extracellular, score 4.8e-50 637910023057 PS00017 ATP/GTP-binding site motif A (P-loop). 637910023058 HMMPfam hit to PF00004, AAA ATPase, core, score 5e-102 637910023059 PS00017 ATP/GTP-binding site motif A (P-loop). 637910023060 PS00674 AAA-protein family signature. 637910023061 HMMPfam hit to PF01434, Peptidase M41, score 1.2e-128 637910023062 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 637910023063 dihydropteroate synthase; Region: DHPS; TIGR01496 637910023064 substrate binding pocket [chemical binding]; other site 637910023065 dimer interface [polypeptide binding]; other site 637910023066 inhibitor binding site; inhibition site 637910023067 PS00792 Dihydropteroate synthase signature 1. 637910023068 HMMPfam hit to PF00809, Dihydropteroate synthase, DHPS, score 2e-107 637910023069 PS00793 Dihydropteroate synthase signature 2. 637910023070 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 637910023071 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 637910023072 active site 637910023073 substrate binding site [chemical binding]; other site 637910023074 metal binding site [ion binding]; metal-binding site 637910023075 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I, score 1.2e-61 637910023076 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 637910023077 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II, score 6.1e-48 637910023078 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III, score 8.9e-43 637910023079 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase C-terminal, score 5.4e-20 637910023080 Toxin-coregulated pilus subunit TcpA; Region: TcpA; pfam05946 637910023081 HMMPfam hit to PF07963, Prepilin-type cleavage/methylation, N-terminal, score 0.0018 637910023082 PS00409 Prokaryotic N-terminal methylation site. 637910023083 1 transmembrane helix predicted for ROD46461 by TMHMM2.0 at aa 28-50 637910023084 HMMPfam hit to PF05946, toxin-coregulated pilus subunit TcpA, score 3.5e-19 637910023085 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 637910023086 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 637910023087 Domain of unknown function (DUF4134); Region: DUF4134; pfam13572 637910023088 1 transmembrane helix predicted for ROD46471 by TMHMM2.0 at aa 7-29 637910023089 HMMPfam hit to PF07963, Prepilin-type cleavage/methylation, N-terminal, score 1.2e-05 637910023090 PS00409 Prokaryotic N-terminal methylation site. 637910023091 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 637910023092 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 637910023093 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023094 1 transmembrane helix predicted for ROD46501 by TMHMM2.0 at aa 154-176 637910023095 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 637910023096 1 transmembrane helix predicted for ROD46511 by TMHMM2.0 at aa 20-42 637910023097 Type II/IV secretion system protein; Region: T2SE; pfam00437 637910023098 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 637910023099 Walker A motif; other site 637910023100 ATP binding site [chemical binding]; other site 637910023101 Walker B motif; other site 637910023102 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 8.8e-45 637910023103 PS00017 ATP/GTP-binding site motif A (P-loop). 637910023104 PS00662 Bacterial type II secretion system protein E signature. 637910023105 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 637910023106 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 637910023107 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 7.6e-14 637910023108 3 transmembrane helices predicted for ROD46541 by TMHMM2.0 at aa 108-130, 157-179 and 308-330 637910023109 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 2.3e-15 637910023110 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 637910023111 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 637910023112 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 637910023113 7 transmembrane helices predicted for ROD46561 by TMHMM2.0 at aa 7-29, 94-116, 123-145, 150-167, 174-196, 216-238 and 259-276 637910023114 HMMPfam hit to PF06750, Peptidase A24A, N-terminal, score 1.6e-34 637910023115 HMMPfam hit to PF01478, Peptidase A24A, prepilin type IV, score 1.3e-12 637910023116 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 637910023117 Peptidase family M23; Region: Peptidase_M23; pfam01551 637910023118 HMMPfam hit to PF01551, Peptidase M23B, score 5.1e-44 637910023119 Preprotein translocase SecG subunit; Region: SecG; pfam03840 637910023120 HMMPfam hit to PF03840, Preprotein translocase SecG subunit, score 3.9e-35 637910023121 2 transmembrane helices predicted for ROD46581 by TMHMM2.0 at aa 21-38 and 67-89 637910023122 Glyco_18 domain; Region: Glyco_18; smart00636 637910023123 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 637910023124 active site 637910023125 PS00017 ATP/GTP-binding site motif A (P-loop). 637910023126 HMMPfam hit to PF00704, Glycoside hydrolase, family 18, catalytic domain, score 2.2e-90 637910023127 PS01095 Chitinases family 18 active site. 637910023128 argininosuccinate synthase; Validated; Region: PRK05370 637910023129 HMMPfam hit to PF00764, Argininosuccinate synthase, score 4.9e-219 637910023130 PS00565 Argininosuccinate synthase signature 2. 637910023131 PS00564 Argininosuccinate synthase signature 1. 637910023132 ribosome maturation protein RimP; Reviewed; Region: PRK00092 637910023133 Sm and related proteins; Region: Sm_like; cl00259 637910023134 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 637910023135 putative oligomer interface [polypeptide binding]; other site 637910023136 putative RNA binding site [nucleotide binding]; other site 637910023137 HMMPfam hit to PF02576, Protein of unknown function DUF150, score 8.6e-72 637910023138 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 637910023139 NusA N-terminal domain; Region: NusA_N; pfam08529 637910023140 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 637910023141 RNA binding site [nucleotide binding]; other site 637910023142 homodimer interface [polypeptide binding]; other site 637910023143 NusA-like KH domain; Region: KH_5; pfam13184 637910023144 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 637910023145 G-X-X-G motif; other site 637910023146 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 637910023147 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 637910023148 HMMPfam hit to PF08529, Transcription factor NusA, N-terminal, score 3.4e-66 637910023149 HMMPfam hit to PF00575, S1, RNA binding, score 1.9e-12 637910023150 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 637910023151 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 637910023152 translation initiation factor IF-2; Region: IF-2; TIGR00487 637910023153 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 637910023154 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 637910023155 G1 box; other site 637910023156 putative GEF interaction site [polypeptide binding]; other site 637910023157 GTP/Mg2+ binding site [chemical binding]; other site 637910023158 Switch I region; other site 637910023159 G2 box; other site 637910023160 G3 box; other site 637910023161 Switch II region; other site 637910023162 G4 box; other site 637910023163 G5 box; other site 637910023164 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 637910023165 Translation-initiation factor 2; Region: IF-2; pfam11987 637910023166 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 637910023167 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-terminal, score 4.7e-10 637910023168 HMMPfam hit to PF08364, Initiation factor 2 associated region, bacterial, score 3.5e-22 637910023169 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-terminal, score 3.6e-21 637910023170 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 1.9e-56 637910023171 PS00017 ATP/GTP-binding site motif A (P-loop). 637910023172 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 2.8e-13 637910023173 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 6.5e-11 637910023174 PS01176 Initiation factor 2 signature. 637910023175 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 637910023176 HMMPfam hit to PF02033, Ribosome-binding factor A, score 1.1e-64 637910023177 PS01319 Ribosome-binding factor A signature. 637910023178 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 637910023179 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 637910023180 RNA binding site [nucleotide binding]; other site 637910023181 active site 637910023182 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 637910023183 HMMPfam hit to PF01509, tRNA pseudouridine synthase B, N-terminal, score 2.3e-91 637910023184 HMMPfam hit to PF09157, tRNA pseudouridine synthase B, C-terminal, score 5.7e-30 637910023185 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 637910023186 16S/18S rRNA binding site [nucleotide binding]; other site 637910023187 S13e-L30e interaction site [polypeptide binding]; other site 637910023188 25S rRNA binding site [nucleotide binding]; other site 637910023189 HMMPfam hit to PF00312, Ribosomal protein S15, score 2.8e-48 637910023190 PS00362 Ribosomal protein S15 signature. 637910023191 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 637910023192 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 637910023193 RNase E interface [polypeptide binding]; other site 637910023194 trimer interface [polypeptide binding]; other site 637910023195 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 637910023196 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 637910023197 RNase E interface [polypeptide binding]; other site 637910023198 trimer interface [polypeptide binding]; other site 637910023199 active site 637910023200 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 637910023201 putative nucleic acid binding region [nucleotide binding]; other site 637910023202 G-X-X-G motif; other site 637910023203 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 637910023204 RNA binding site [nucleotide binding]; other site 637910023205 domain interface; other site 637910023206 HMMPfam hit to PF01138, Exoribonuclease, phosphorolytic domain 1, score 9.2e-44 637910023207 HMMPfam hit to PF03725, Exoribonuclease, phosphorolytic domain 2, score 2.8e-19 637910023208 HMMPfam hit to PF03726, Polynucleotide phosphorylase, phosphorolytic RNA-binding, bacterial/organelle-type, score 2.5e-38 637910023209 HMMPfam hit to PF01138, Exoribonuclease, phosphorolytic domain 1, score 1e-54 637910023210 HMMPfam hit to PF03725, Exoribonuclease, phosphorolytic domain 2, score 1.3e-20 637910023211 HMMPfam hit to PF00013, K Homology, type 1, score 1.5e-16 637910023212 HMMPfam hit to PF00575, S1, RNA binding, score 3.2e-27 637910023213 lipoprotein NlpI; Provisional; Region: PRK11189 637910023214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 637910023215 binding surface 637910023216 TPR motif; other site 637910023217 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023218 HMMPfam hit to PF00515, Tetratricopeptide TPR-1, score 0.00013 637910023219 HMMPfam hit to PF00515, Tetratricopeptide TPR-1, score 1.2e-06 637910023220 HMMPfam hit to PF00515, Tetratricopeptide TPR-1, score 0.22 637910023221 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 637910023222 DEAD-like helicases superfamily; Region: DEXDc; smart00487 637910023223 ATP binding site [chemical binding]; other site 637910023224 Mg++ binding site [ion binding]; other site 637910023225 motif III; other site 637910023226 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 637910023227 nucleotide binding region [chemical binding]; other site 637910023228 ATP-binding site [chemical binding]; other site 637910023229 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 637910023230 putative RNA binding site [nucleotide binding]; other site 637910023231 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 8.6e-76 637910023232 PS00017 ATP/GTP-binding site motif A (P-loop). 637910023233 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 637910023234 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 2.7e-34 637910023235 HMMPfam hit to PF03880, DbpA, RNA-binding, score 9.5e-42 637910023236 tryptophan permease; Provisional; Region: PRK10483 637910023237 aromatic amino acid transport protein; Region: araaP; TIGR00837 637910023238 HMMPfam hit to PF03222, Aromatic amino acid permease, score 1.4e-219 637910023239 10 transmembrane helices predicted for ROD46711 by TMHMM2.0 at aa 10-32, 59-81, 96-118, 125-147, 162-184, 197-219, 256-278, 290-312, 317-339 and 360-382 637910023240 hypothetical protein; Provisional; Region: PRK10508 637910023241 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 637910023242 HMMPfam hit to PF00296, Bacterial luciferase-like, score 4.5e-16 637910023243 putative protease; Provisional; Region: PRK15447 637910023244 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 637910023245 HMMPfam hit to PF01136, Peptidase U32, score 4.2e-07 637910023246 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 637910023247 Peptidase family U32; Region: Peptidase_U32; pfam01136 637910023248 HMMPfam hit to PF01136, Peptidase U32, score 2.6e-121 637910023249 PS01276 Peptidase family U32 signature. 637910023250 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 637910023251 HMMPfam hit to PF02036, Sterol-binding, score 9.5e-29 637910023252 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 637910023253 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637910023254 Coenzyme A binding pocket [chemical binding]; other site 637910023255 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2.9e-15 637910023256 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 637910023257 GIY-YIG motif/motif A; other site 637910023258 putative active site [active] 637910023259 putative metal binding site [ion binding]; other site 637910023260 HMMPfam hit to PF01541, Excinuclease ABC, C subunit, N-terminal, score 1.5e-16 637910023261 hypothetical protein; Provisional; Region: PRK03467 637910023262 intracellular protease, PfpI family; Region: PfpI; TIGR01382 637910023263 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 637910023264 proposed catalytic triad [active] 637910023265 conserved cys residue [active] 637910023266 HMMPfam hit to PF01965, ThiJ/PfpI, score 1.4e-53 637910023267 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 637910023268 NADH(P)-binding; Region: NAD_binding_10; pfam13460 637910023269 NAD binding site [chemical binding]; other site 637910023270 active site 637910023271 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD - binding, score 5.9e-06 637910023272 Predicted permease; Region: DUF318; pfam03773 637910023273 9 transmembrane helices predicted for ROD46821 by TMHMM2.0 at aa 15-32, 74-96, 111-133, 146-168, 172-191, 226-248, 263-285, 292-314 and 324-344 637910023274 HMMPfam hit to PF03773, Protein of unknown function DUF318, transmembrane, score 2.2e-105 637910023275 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023276 outer membrane lipoprotein; Provisional; Region: PRK11023 637910023277 BON domain; Region: BON; pfam04972 637910023278 BON domain; Region: BON; pfam04972 637910023279 HMMPfam hit to PF04972, Transport-associated, score 1.6e-12 637910023280 HMMPfam hit to PF04972, Transport-associated, score 1.5e-11 637910023281 1 transmembrane helix predicted for ROD46831 by TMHMM2.0 at aa 7-29 637910023282 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023283 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 637910023284 dimer interface [polypeptide binding]; other site 637910023285 active site 637910023286 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 637910023287 HMMPfam hit to PF02021, Protein of unknown function UPF0102, score 9.6e-50 637910023288 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 637910023289 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 637910023290 putative ligand binding site [chemical binding]; other site 637910023291 HMMPfam hit to PF04348, LppC lipoprotein, score 6.1e-103 637910023292 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023293 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 637910023294 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 637910023295 putative SAM binding site [chemical binding]; other site 637910023296 putative homodimer interface [polypeptide binding]; other site 637910023297 HMMPfam hit to PF00590, Tetrapyrrole methylase, score 5.4e-73 637910023298 PS01296 Uncharacterized protein family UPF0011 signature. 637910023299 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 637910023300 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 637910023301 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 637910023302 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 2.1e-51 637910023303 PS00141 Eukaryotic and viral aspartyl proteases active site. 637910023304 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 7.7e-18 637910023305 PS00894 Bacterial regulatory proteins, deoR family signature. 637910023306 pseudogene, disrupted by prophage CRP49 insertion 637910023307 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 3.1e-38 637910023308 prophage CRP49 637910023309 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 637910023310 Predicted helix-turn-helix motif with score 1619.000, SD 4.70 at aa 28-49, sequence RSMRQAAMDWGLSYSTLNNYFE 637910023311 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 637910023312 Predicted helix-turn-helix motif with score 1461.000, SD 4.16 at aa 24-45, sequence GSMRALARKAGVGQNNLYNAVY 637910023313 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 637910023314 Integrase core domain; Region: rve; pfam00665 637910023315 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 637910023316 HMMPfam hit to PF00665, Integrase, catalytic core, score 6.3e-09 637910023317 HMMPfam hit to PF09299, Transposase-like, Mu, C-terminal, score 2.7e-28 637910023318 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 637910023319 AAA domain; Region: AAA_30; pfam13604 637910023320 Mu B transposition protein, C terminal; Region: Phage-MuB_C; pfam09077 637910023321 Predicted helix-turn-helix motif with score 1524.000, SD 4.38 at aa 20-41, sequence LTQYAIAREAGISDGTLSAFRK 637910023322 PS00017 ATP/GTP-binding site motif A (P-loop). 637910023323 HMMPfam hit to PF09077, B transposition protein, C-terminal, score 2.5e-45 637910023324 Mu-like prophage host-nuclease inhibitor protein Gam [General function prediction only]; Region: COG4396 637910023325 HMMPfam hit to PF07352, Bacteriophage Mu Gam like, score 2.7e-131 637910023326 Predicted helix-turn-helix motif with score 1162.000, SD 3.14 at aa 20-41, sequence LTCGVLAEKMNMPPSSMVYFLR 637910023327 PS00037 Myb DNA-binding domain repeat signature 1. 637910023328 Predicted helix-turn-helix motif with score 1510.000, SD 4.33 at aa 147-168, sequence LTFREIGEKFELSESTVNFIYH 637910023329 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 637910023330 Mu-like prophage protein gp16 [Function unknown]; Region: COG4382 637910023331 HMMPfam hit to PF06252, Protein of unknown function DUF1018, score 2.8e-82 637910023332 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 637910023333 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910023334 HMMPfam hit to PF01609, Transposase, IS4-like, score 3.6e-29 637910023335 Uncharacterized conserved protein [Function unknown]; Region: COG5566 637910023336 HMMPfam hit to PF08765, Mor transcription activator, score 3.6e-42 637910023337 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 637910023338 catalytic residues [active] 637910023339 1 transmembrane helix predicted for ROD47111 by TMHMM2.0 at aa 13-32 637910023340 HMMPfam hit to PF00959, Glycoside hydrolase, family 24, score 9.4e-23 637910023341 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023342 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 637910023343 1 transmembrane helix predicted for ROD47131 by TMHMM2.0 at aa 10-27 637910023344 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 637910023345 putative DNA binding helix; other site 637910023346 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 637910023347 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 637910023348 Protein of unknown function (DUF935); Region: DUF935; pfam06074 637910023349 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 637910023350 HMMPfam hit to PF06074, Protein of unknown function DUF935, score 0 637910023351 Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369 637910023352 Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233 637910023353 HMMPfam hit to PF04233, Phage head morphogenesis protein, SPP1 gp7, score 4.6e-52 637910023354 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 637910023355 HMMPfam hit to PF05069, Phage virion morphogenesis ( tail completion) protein, score 1.8e-42 637910023356 Mu-like prophage I protein [General function prediction only]; Region: COG4388 637910023357 Mu-like prophage I protein [General function prediction only]; Region: COG4388 637910023358 PS00017 ATP/GTP-binding site motif A (P-loop). 637910023359 Mu-like prophage major head subunit gpT [General function prediction only]; Region: COG4397 637910023360 Mu-like prophage protein gp36 [Function unknown]; Region: COG4387 637910023361 HMMPfam hit to PF07030, Protein of unknown function DUF1320, score 4.8e-81 637910023362 1 transmembrane helix predicted for ROD47241 by TMHMM2.0 at aa 55-77 637910023363 Mu-like prophage protein gp37 [General function prediction only]; Region: COG5003 637910023364 HMMPfam hit to PF08873, Protein of unknown function DUF1834, score 1.2e-49 637910023365 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 637910023366 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 637910023367 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 637910023368 HMMPfam hit to PF06274, Bacteriophage Mu tail sheath, score 2.6e-288 637910023369 Phage tail tube protein; Region: Tail_tube; pfam10618 637910023370 Mu-like prophage FluMu protein gp41 [Function unknown]; Region: COG4518 637910023371 Mu-like prophage protein [General function prediction only]; Region: COG3941 637910023372 tape measure domain; Region: tape_meas_nterm; TIGR02675 637910023373 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 637910023374 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 637910023375 HMMPfam hit to PF07157, DNA circulation, N-terminal, score 8e-47 637910023376 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 637910023377 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 637910023378 HMMPfam hit to PF06893, Bacteriophage Mu P, score 3.2e-172 637910023379 Mu-like prophage protein gp45 [Function unknown]; Region: COG4384 637910023380 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 637910023381 HMMPfam hit to PF06890, Bacteriophage Mu Gp45, score 2.9e-94 637910023382 PS00017 ATP/GTP-binding site motif A (P-loop). 637910023383 Mu-like prophage protein gp46 [Function unknown]; Region: COG4381 637910023384 HMMPfam hit to PF07409, Phage GP46, score 2.9e-70 637910023385 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 637910023386 HMMPfam hit to PF04865, Phage baseplate assembly predicted J-like, score 5.1e-97 637910023387 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 637910023388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 637910023389 invertible tail fibre region of prophage CRP49 637910023390 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 637910023391 HMMPfam hit to PF02413, Phage tail assembly chaperone gp38, score 1.2e-29 637910023392 C-terminal region of tail fibre, alternative tail fibre tip, contains inverted repeat sequence found in tail fibre ROD47371 637910023393 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 637910023394 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 637910023395 catalytic residues [active] 637910023396 catalytic nucleophile [active] 637910023397 Presynaptic Site I dimer interface [polypeptide binding]; other site 637910023398 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 637910023399 Synaptic Flat tetramer interface [polypeptide binding]; other site 637910023400 Synaptic Site I dimer interface [polypeptide binding]; other site 637910023401 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 637910023402 DNA-binding interface [nucleotide binding]; DNA binding site 637910023403 HMMPfam hit to PF00239, Resolvase, N-terminal, score 1.6e-72 637910023404 PS00397 Site-specific recombinases active site. 637910023405 PS00398 Site-specific recombinases signature 2. 637910023406 HMMPfam hit to PF02796, Resolvase, helix-turn-helix region, score 2.7e-14 637910023407 Predicted helix-turn-helix motif with score 1766.000, SD 5.20 at aa 159-180, sequence ESRKQIALIFDIGLSTLYRYFP 637910023408 Domain of unknown function (DUF303); Region: DUF303; pfam03629 637910023409 HMMPfam hit to PF03629, Protein of unknown function DUF303, acetylesterase , score 2.9e-23 637910023410 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 637910023411 HMMPfam hit to PF07125, Protein of unknown function DUF1378, score 8.2e-35 637910023412 1 transmembrane helix predicted for ROD47421 by TMHMM2.0 at aa 6-25 637910023413 Protein of unknown function (DUF826); Region: DUF826; pfam05696 637910023414 HMMPfam hit to PF05696, Protein of unknown function DUF826, score 3.2e-37 637910023415 Mu-like prophage protein Com [General function prediction only]; Region: Com; COG4416 637910023416 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 4.7e-44 637910023417 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 637910023418 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 637910023419 9 transmembrane helices predicted for ROD47471 by TMHMM2.0 at aa 4-26, 39-61, 90-112, 133-155, 225-247, 299-321, 331-348, 353-375 and 411-433 637910023420 HMMPfam hit to PF03611, Phosphotransferase system, galactitol-specific IIC component, score 2e-186 637910023421 PS00962 Ribosomal protein S2 signature 1. 637910023422 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 637910023423 active site 637910023424 P-loop; other site 637910023425 phosphorylation site [posttranslational modification] 637910023426 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 3.6e-17 637910023427 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 637910023428 active site 637910023429 phosphorylation site [posttranslational modification] 637910023430 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 6.1e-08 637910023431 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 637910023432 HMMPfam hit to PF08013, D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit AgaZ, score 0 637910023433 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 637910023434 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 637910023435 intersubunit interface [polypeptide binding]; other site 637910023436 active site 637910023437 zinc binding site [ion binding]; other site 637910023438 Na+ binding site [ion binding]; other site 637910023439 HMMPfam hit to PF01116, Ketose-bisphosphate aldolase, class-II, score 6.9e-141 637910023440 PS00806 Fructose-bisphosphate aldolase class-II signature 2. 637910023441 galactarate dehydratase; Region: galactar-dH20; TIGR03248 637910023442 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 637910023443 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 637910023444 HMMPfam hit to PF04295, D-galactarate dehydratase/Altronate hydrolase, C-terminal, score 9.7e-250 637910023445 HMMPfam hit to PF08666, SAF domain, score 2.4e-13 637910023446 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 637910023447 HMMPfam hit to PF03328, HpcH/HpaI aldolase, score 4.2e-106 637910023448 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 637910023449 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 637910023450 HMMPfam hit to PF03446, 6-phosphogluconate dehydrogenase, NAD-binding, score 6e-84 637910023451 PS00895 3-hydroxyisobutyrate dehydrogenase signature. 637910023452 glycerate kinase I; Provisional; Region: PRK10342 637910023453 HMMPfam hit to PF02595, Glycerate kinase, score 7.9e-273 637910023454 PS00017 ATP/GTP-binding site motif A (P-loop). 637910023455 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 637910023456 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 637910023457 HMMPfam hit to PF03264, NapC/NirT cytochrome c, N-terminal, score 2e-94 637910023458 1 transmembrane helix predicted for ROD47571 by TMHMM2.0 at aa 13-35 637910023459 PS00190 Cytochrome c family heme-binding site signature. 637910023460 PS00190 Cytochrome c family heme-binding site signature. 637910023461 PS00190 Cytochrome c family heme-binding site signature. 637910023462 PS00190 Cytochrome c family heme-binding site signature. 637910023463 PS00018 EF-hand calcium-binding domain. 637910023464 PS00190 Cytochrome c family heme-binding site signature. 637910023465 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 637910023466 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 637910023467 molybdopterin cofactor binding site [chemical binding]; other site 637910023468 substrate binding site [chemical binding]; other site 637910023469 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 637910023470 molybdopterin cofactor binding site; other site 637910023471 1 transmembrane helix predicted for ROD47581 by TMHMM2.0 at aa 26-43 637910023472 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1.1e-135 637910023473 PS00017 ATP/GTP-binding site motif A (P-loop). 637910023474 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 637910023475 HMMPfam hit to PF01568, Molydopterin dinucleotide-binding region, score 9.7e-33 637910023476 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 637910023477 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910023478 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 637910023479 putative substrate binding pocket [chemical binding]; other site 637910023480 putative dimerization interface [polypeptide binding]; other site 637910023481 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 6.6e-21 637910023482 Predicted helix-turn-helix motif with score 2018.000, SD 6.06 at aa 22-43, sequence GSIGSAAKELGLTQPAVSKIIN 637910023483 PS00044 Bacterial regulatory proteins, lysR family signature. 637910023484 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.9e-31 637910023485 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 637910023486 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 637910023487 tetramer interface [polypeptide binding]; other site 637910023488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910023489 catalytic residue [active] 637910023490 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 3.6e-96 637910023491 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 637910023492 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023493 threonine/serine transporter TdcC; Provisional; Region: PRK13629 637910023494 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 637910023495 11 transmembrane helices predicted for ROD47611 by TMHMM2.0 at aa 23-40, 44-66, 97-119, 134-156, 163-185, 212-234, 255-277, 311-333, 358-380, 390-409 and 422-440 637910023496 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023497 propionate/acetate kinase; Provisional; Region: PRK12379 637910023498 Acetokinase family; Region: Acetate_kinase; cl17229 637910023499 HMMPfam hit to PF00871, Acetate and butyrate kinase, score 1e-232 637910023500 PS01075 Acetate and butyrate kinases family signature 1. 637910023501 PS01076 Acetate and butyrate kinases family signature 2. 637910023502 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 637910023503 Pyruvate formate lyase 1; Region: PFL1; cd01678 637910023504 coenzyme A binding site [chemical binding]; other site 637910023505 active site 637910023506 catalytic residues [active] 637910023507 glycine loop; other site 637910023508 HMMPfam hit to PF02901, Pyruvate formate-lyase, PFL, score 0 637910023509 HMMPfam hit to PF01228, Formate C-acetyltransferase glycine radical, score 2.8e-59 637910023510 PS00850 Glycine radical signature. 637910023511 L-serine dehydratase TdcG; Provisional; Region: PRK15040 637910023512 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 637910023513 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 637910023514 HMMPfam hit to PF03315, Serine dehydratase subunit beta, score 2.5e-90 637910023515 HMMPfam hit to PF03313, Serine dehydratase subunit alpha, score 3e-192 637910023516 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 637910023517 serine transporter; Region: stp; TIGR00814 637910023518 11 transmembrane helices predicted for ROD47651 by TMHMM2.0 at aa 17-39, 44-66, 91-113, 128-150, 163-185, 200-222, 243-265, 300-322, 343-362, 367-389 and 402-421 637910023519 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023520 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 637910023521 HMMPfam hit to PF06354, Protein of unknown function DUF1063, score 1.6e-260 637910023522 Pirin-related protein [General function prediction only]; Region: COG1741 637910023523 Pirin; Region: Pirin; pfam02678 637910023524 HMMPfam hit to PF02678, Pirin, N-terminal, score 7.6e-39 637910023525 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910023526 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 637910023527 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637910023528 dimerization interface [polypeptide binding]; other site 637910023529 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 3.2e-15 637910023530 Predicted helix-turn-helix motif with score 1071.000, SD 2.83 at aa 22-43, sequence GSFAAAADELGRVPSALSYTMQ 637910023531 PS00044 Bacterial regulatory proteins, lysR family signature. 637910023532 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.3e-12 637910023533 Protein of unknown function (DUF805); Region: DUF805; pfam05656 637910023534 HMMPfam hit to PF05656, Protein of unknown function DUF805, score 2.4e-47 637910023535 3 transmembrane helices predicted for ROD47701 by TMHMM2.0 at aa 23-45, 49-71 and 78-100 637910023536 Predicted membrane protein [Function unknown]; Region: COG3152 637910023537 HMMPfam hit to PF05656, Protein of unknown function DUF805, score 5.1e-50 637910023538 3 transmembrane helices predicted for ROD47711 by TMHMM2.0 at aa 23-40, 49-71 and 81-103 637910023539 pseudogene, N-terminal 150 aa missing, fragment 637910023540 CR_GI12 637910023541 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910023542 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910023543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910023544 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910023545 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910023546 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910023547 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910023548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910023549 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910023550 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 5.7e-70 637910023551 Transposase; Region: HTH_Tnp_1; pfam01527 637910023552 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910023553 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910023554 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910023555 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145 637910023556 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 637910023557 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 637910023558 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 637910023559 pseudogene, N-terminus missing, fragment 637910023560 HMMPfam hit to PF00665, Integrase, catalytic core, score 7.5e-05 637910023561 pseudogene, N-terminus missing, C-terminal part truncated by premature stop codon 637910023562 HMMPfam hit to PF01695, IstB-like ATP-binding protein, score 5.4e-50 637910023563 pseudogene, C-terminus missing, N-terminal part truncated by premature stop codon; Similar to IS911 ORF1 637910023564 pseudogene, N-terminus missing, C-terminal part truncated by premature stop codon; Similar to IS911 ORF2 637910023565 HMMPfam hit to PF00665, Integrase, catalytic core, score 7.2e-30 637910023566 pseudogene, N- and C-termini missing, additionally fragmented by premature stop codon and frameshift mutation 637910023567 Predicted membrane protein [Function unknown]; Region: COG2259 637910023568 4 transmembrane helices predicted for ROD47861 by TMHMM2.0 at aa 31-53, 68-90, 95-112 and 127-144 637910023569 HMMPfam hit to PF07681, DoxX, score 5.5e-25 637910023570 YqjK-like protein; Region: YqjK; pfam13997 637910023571 Predicted membrane protein [Function unknown]; Region: COG5393 637910023572 2 transmembrane helices predicted for ROD47881 by TMHMM2.0 at aa 50-72 and 82-104 637910023573 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 637910023574 HMMPfam hit to PF05957, Protein of unknown function DUF883, ElaB, score 1.1e-51 637910023575 1 transmembrane helix predicted for ROD47891 by TMHMM2.0 at aa 81-98 637910023576 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 637910023577 HMMPfam hit to PF06476, Protein of unknown function DUF1090, score 6.7e-52 637910023578 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 637910023579 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 637910023580 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 637910023581 6 transmembrane helices predicted for ROD47921 by TMHMM2.0 at aa 19-38, 42-64, 71-93, 126-148, 153-175 and 190-212 637910023582 HMMPfam hit to PF09335, SNARE associated Golgi protein, score 4.9e-07 637910023583 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023584 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 637910023585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910023586 DNA-binding site [nucleotide binding]; DNA binding site 637910023587 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 637910023588 HMMPfam hit to PF07729, GntR, C-terminal, score 9.6e-30 637910023589 PS00904 Protein prenyltransferases subunit alpha repeat signature. 637910023590 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 1.2e-29 637910023591 PS00043 Bacterial regulatory proteins, gntR family signature. 637910023592 pseudogene, truncated by frameshift mutation 637910023593 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 7.7e-70 637910023594 Glucuronate isomerase; Region: UxaC; pfam02614 637910023595 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 637910023596 HMMPfam hit to PF02614, Glucuronate isomerase, score 0 637910023597 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 637910023598 galactarate dehydratase; Region: galactar-dH20; TIGR03248 637910023599 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 637910023600 HMMPfam hit to PF08666, SAF domain, score 8.6e-15 637910023601 HMMPfam hit to PF04295, D-galactarate dehydratase/Altronate hydrolase, C-terminal, score 1.4e-264 637910023602 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023603 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023604 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 637910023605 4 transmembrane helices predicted for ROD47971 by TMHMM2.0 at aa 2-24, 39-61, 74-96 and 135-157 637910023606 serine/threonine transporter SstT; Provisional; Region: PRK13628 637910023607 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 637910023608 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter, score 5.7e-173 637910023609 8 transmembrane helices predicted for ROD47981 by TMHMM2.0 at aa 13-35, 50-72, 84-106, 144-166, 187-209, 219-240, 292-314 and 329-351 637910023610 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023611 PS00435 Peroxidases proximal heme-ligand signature. 637910023612 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023613 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 637910023614 9 transmembrane helices predicted for ROD47991 by TMHMM2.0 at aa 10-29, 42-64, 79-101, 114-136, 142-161, 198-220, 235-257, 264-286 and 290-312 637910023615 HMMPfam hit to PF03741, Integral membrane protein TerC, score 4e-61 637910023616 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 637910023617 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 637910023618 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 1.2e-42 637910023619 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 637910023620 HMMPfam hit to PF01863, Protein of unknown function DUF45, score 0.00037 637910023621 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 637910023622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910023623 S-adenosylmethionine binding site [chemical binding]; other site 637910023624 HMMPfam hit to PF05175, Methyltransferase small, score 4.8e-83 637910023625 PS00092 N-6 Adenine-specific DNA methylases signature. 637910023626 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 637910023627 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 637910023628 active site 637910023629 FMN binding site [chemical binding]; other site 637910023630 2,4-decadienoyl-CoA binding site; other site 637910023631 catalytic residue [active] 637910023632 4Fe-4S cluster binding site [ion binding]; other site 637910023633 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 637910023634 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 4.8e-07 637910023635 HMMPfam hit to PF00724, NADH:flavin oxidoreductase/NADH oxidase, N-terminal, score 1.4e-144 637910023636 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 637910023637 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 637910023638 inhibitor-cofactor binding pocket; inhibition site 637910023639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910023640 catalytic residue [active] 637910023641 HMMPfam hit to PF00202, Aminotransferase class-III, score 1.9e-184 637910023642 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 637910023643 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 637910023644 PAS fold; Region: PAS_3; pfam08447 637910023645 putative active site [active] 637910023646 heme pocket [chemical binding]; other site 637910023647 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 637910023648 dimerization interface [polypeptide binding]; other site 637910023649 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637910023650 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637910023651 dimer interface [polypeptide binding]; other site 637910023652 putative CheW interface [polypeptide binding]; other site 637910023653 HMMPfam hit to PF08447, PAS fold-3, score 2.5e-17 637910023654 1 transmembrane helix predicted for ROD48061 by TMHMM2.0 at aa 167-189 637910023655 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 0.00023 637910023656 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 2.7e-61 637910023657 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910023658 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 637910023659 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637910023660 dimerization interface [polypeptide binding]; other site 637910023661 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 637910023662 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637910023663 dimer interface [polypeptide binding]; other site 637910023664 putative CheW interface [polypeptide binding]; other site 637910023665 2 transmembrane helices predicted for ROD48071 by TMHMM2.0 at aa 12-34 and 189-211 637910023666 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 6.5e-14 637910023667 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023668 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 1.3e-72 637910023669 Predicted transcriptional regulators [Transcription]; Region: COG1695 637910023670 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 637910023671 HMMPfam hit to PF03551, Transcriptional regulator PadR-like, score 7.1e-20 637910023672 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 637910023673 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 637910023674 FAD binding pocket [chemical binding]; other site 637910023675 FAD binding motif [chemical binding]; other site 637910023676 phosphate binding motif [ion binding]; other site 637910023677 NAD binding pocket [chemical binding]; other site 637910023678 HMMPfam hit to PF08021, FAD-binding 9, siderophore-interacting, score 4.2e-49 637910023679 HMMPfam hit to PF04954, Siderophore-interacting protein, score 7.7e-34 637910023680 1 transmembrane helix predicted for ROD48111 by TMHMM2.0 at aa 7-26 637910023681 CR_GI13 637910023682 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 637910023683 1 transmembrane helix predicted for ROD48151 by TMHMM2.0 at aa 5-27 637910023684 HMMPfam hit to PF02321, Outer membrane efflux protein, score 9.9e-21 637910023685 HMMPfam hit to PF02321, Outer membrane efflux protein, score 3.3e-09 637910023686 pseudogene, truncated by premature stop codon 637910023687 HMMPfam hit to PF04509, CheC-like protein, score 2.1 637910023688 HMMPfam hit to PF04509, CheC-like protein, score 36 637910023689 HMMPfam hit to PF04509, CheC-like protein, score 2.1 637910023690 HMMPfam hit to PF04509, CheC-like protein, score 13 637910023691 HMMPfam hit to PF04509, CheC-like protein, score 2.1 637910023692 HMMPfam hit to PF04509, CheC-like protein, score 42 637910023693 HMMPfam hit to PF04509, CheC-like protein, score 13 637910023694 HMMPfam hit to PF04509, CheC-like protein, score 1.4 637910023695 HMMPfam hit to PF04509, CheC-like protein, score 9.4 637910023696 HMMPfam hit to PF04509, CheC-like protein, score 2.1 637910023697 HMMPfam hit to PF04509, CheC-like protein, score 2.1 637910023698 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 5 637910023699 HMMPfam hit to PF04509, CheC-like protein, score 44 637910023700 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 0.21 637910023701 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 0.26 637910023702 HMMPfam hit to PF04509, CheC-like protein, score 53 637910023703 HMMPfam hit to PF02012, Glycoside hydrolase, BNR repeat, score 0.78 637910023704 HMMPfam hit to PF01839, FG-GAP, score 0.00077 637910023705 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 637910023706 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 637910023707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 637910023708 Walker A/P-loop; other site 637910023709 ATP binding site [chemical binding]; other site 637910023710 Q-loop/lid; other site 637910023711 ABC transporter signature motif; other site 637910023712 Walker B; other site 637910023713 D-loop; other site 637910023714 H-loop/switch region; other site 637910023715 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 8.7e-11 637910023716 3 transmembrane helices predicted for ROD48181 by TMHMM2.0 at aa 161-183, 193-212 and 281-303 637910023717 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023718 HMMPfam hit to PF00005, ABC transporter related, score 3.7e-54 637910023719 PS00017 ATP/GTP-binding site motif A (P-loop). 637910023720 PS00211 ABC transporters family signature. 637910023721 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 637910023722 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 637910023723 HlyD family secretion protein; Region: HlyD_3; pfam13437 637910023724 PS00228 Tubulin-beta mRNA autoregulation signal. 637910023725 1 transmembrane helix predicted for ROD48191 by TMHMM2.0 at aa 21-40 637910023726 HMMPfam hit to PF00529, Secretion protein HlyD, score 1.2e-16 637910023727 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 637910023728 PS00543 HlyD family secretion proteins signature. 637910023729 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 637910023730 PS00294 Prenyl group binding site (CAAX box). 637910023731 12 transmembrane helices predicted for ROD48201 by TMHMM2.0 at aa 12-34, 54-76, 83-105, 110-132, 139-161, 171-193, 213-235, 245-267, 272-294, 299-321, 326-348 and 363-385 637910023732 HMMPfam hit to PF06779, Protein of unknown function DUF1228, score 3.2e-44 637910023733 SdiA-regulated; Region: SdiA-regulated; cd09971 637910023734 SdiA-regulated; Region: SdiA-regulated; pfam06977 637910023735 putative active site [active] 637910023736 HMMPfam hit to PF06977, SdiA-regulated, score 2.4e-37 637910023737 1 transmembrane helix predicted for ROD48211 by TMHMM2.0 at aa 13-35 637910023738 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023739 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023740 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 637910023741 HMMPfam hit to PF07470, Glycosyl hydrolase, family 88, score 7.4e-86 637910023742 Protein of unknown function (DUF445); Region: DUF445; pfam04286 637910023743 3 transmembrane helices predicted for ROD48251 by TMHMM2.0 at aa 13-35, 40-62 and 398-420 637910023744 HMMPfam hit to PF04286, Protein of unknown function DUF445, transmembrane, score 8.1e-153 637910023745 Transcriptional regulator [Transcription]; Region: LysR; COG0583 637910023746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910023747 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 637910023748 putative effector binding pocket; other site 637910023749 dimerization interface [polypeptide binding]; other site 637910023750 HMMPfam hit to PF03466, LysR, substrate-binding, score 5.2e-34 637910023751 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 3.6e-20 637910023752 PS00044 Bacterial regulatory proteins, lysR family signature. 637910023753 Predicted helix-turn-helix motif with score 1697.000, SD 4.97 at aa 20-41, sequence GGLSEAASQLNVSPSAVSKSLA 637910023754 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 637910023755 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 637910023756 10 transmembrane helices predicted for ROD48271 by TMHMM2.0 at aa 12-31, 41-63, 76-98, 133-155, 176-198, 213-235, 248-270, 296-315, 322-344 and 348-370 637910023757 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter, score 1.4e-10 637910023758 cystathionine beta-lyase; Provisional; Region: PRK08114 637910023759 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 637910023760 homodimer interface [polypeptide binding]; other site 637910023761 substrate-cofactor binding pocket; other site 637910023762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910023763 catalytic residue [active] 637910023764 HMMPfam hit to PF01053, Cys/Met metabolism, pyridoxal phosphate-dependent enzyme, score 1.2e-149 637910023765 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 637910023766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910023767 putative substrate translocation pore; other site 637910023768 12 transmembrane helices predicted for ROD48291 by TMHMM2.0 at aa 13-35, 50-72, 84-103, 107-129, 141-163, 167-189, 219-241, 256-278, 290-312, 316-338, 350-372 and 377-394 637910023769 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.5e-32 637910023770 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023771 PS00216 Sugar transport proteins signature 1. 637910023772 LysE type translocator; Region: LysE; cl00565 637910023773 6 transmembrane helices predicted for ROD48301 by TMHMM2.0 at aa 15-37, 44-66, 76-98, 119-141, 156-178 and 190-212 637910023774 HMMPfam hit to PF01810, Lysine exporter protein (LYSE/YGGA), score 7.4e-12 637910023775 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 637910023776 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 637910023777 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910023778 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 7.1e-06 637910023779 PS00041 Bacterial regulatory proteins, araC family signature. 637910023780 HMMPfam hit to PF02311, AraC protein, arabinose-binding/dimerisation, score 1.6e-15 637910023781 hypothetical protein; Provisional; Region: PRK09956 637910023782 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 637910023783 HMMPfam hit to PF04754, Transposase (), YhgA-like, score 2.2e-202 637910023784 Nuclease-related domain; Region: NERD; pfam08378 637910023785 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 637910023786 ATP binding site [chemical binding]; other site 637910023787 putative Mg++ binding site [ion binding]; other site 637910023788 Family description; Region: UvrD_C_2; pfam13538 637910023789 HMMPfam hit to PF00580, DNA helicase, UvrD/REP type, score 6.8e-05 637910023790 PS00017 ATP/GTP-binding site motif A (P-loop). 637910023791 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 637910023792 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 637910023793 P-loop, Walker A motif; other site 637910023794 Base recognition motif; other site 637910023795 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 637910023796 HMMPfam hit to PF07683, Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal, score 4.8e-34 637910023797 HMMPfam hit to PF02492, Cobalamin (vitamin B12) biosynthesis CobW-like, score 3.2e-76 637910023798 PS00017 ATP/GTP-binding site motif A (P-loop). 637910023799 Uncharacterized small protein [Function unknown]; Region: COG2879 637910023800 HMMPfam hit to PF04328, Protein of unknown function DUF466, score 3.9e-45 637910023801 carbon starvation protein A; Provisional; Region: PRK15015 637910023802 Carbon starvation protein CstA; Region: CstA; pfam02554 637910023803 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 637910023804 16 transmembrane helices predicted for ROD48371 by TMHMM2.0 at aa 12-29, 34-56, 89-111, 121-140, 161-183, 193-215, 220-242, 257-279, 286-305, 325-347, 364-386, 486-505, 532-551, 566-588, 595-617 and 662-684 637910023805 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023806 HMMPfam hit to PF02554, Carbon starvation protein CstA, score 1.1e-287 637910023807 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023808 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023809 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 637910023810 HMMPfam hit to PF02615, Malate/L-lactate dehydrogenase, score 6.1e-54 637910023811 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 637910023812 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 637910023813 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 637910023814 dimer interface [polypeptide binding]; other site 637910023815 active site 637910023816 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637910023817 substrate binding site [chemical binding]; other site 637910023818 catalytic residue [active] 637910023819 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 637910023820 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 637910023821 active site 637910023822 putative substrate binding pocket [chemical binding]; other site 637910023823 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 637910023824 HMMPfam hit to PF07969, Amidohydrolase 3, score 2.8e-32 637910023825 HMMPfam hit to PF07908, D-aminoacylase, C-terminal, score 1.3e-16 637910023826 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 637910023827 homotrimer interaction site [polypeptide binding]; other site 637910023828 putative active site [active] 637910023829 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 3.4e-21 637910023830 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 637910023831 Na binding site [ion binding]; other site 637910023832 13 transmembrane helices predicted for ROD48421 by TMHMM2.0 at aa 5-24, 36-58, 73-95, 116-138, 158-177, 184-206, 226-243, 264-286, 296-318, 357-376, 386-405, 412-434 and 439-461 637910023833 HMMPfam hit to PF00474, Na+/solute symporter, score 7.7e-22 637910023834 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 637910023835 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 637910023836 HMMPfam hit to PF05035, 2-keto-3-deoxy-galactonokinase, score 2.4e-95 637910023837 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 637910023838 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 637910023839 active site 637910023840 intersubunit interface [polypeptide binding]; other site 637910023841 catalytic residue [active] 637910023842 HMMPfam hit to PF01081, KDPG and KHG aldolase, score 8.3e-12 637910023843 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 637910023844 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 637910023845 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 637910023846 putative active site [active] 637910023847 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 5.2e-22 637910023848 HMMPfam hit to PF01418, Helix-turn-helix protein RpiR, score 8.3e-15 637910023849 Predicted helix-turn-helix motif with score 1200.000, SD 3.27 at aa 39-60, sequence LPIAELARLTETSQASVTRFAR 637910023850 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 637910023851 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 637910023852 dimer interface [polypeptide binding]; other site 637910023853 ligand binding site [chemical binding]; other site 637910023854 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637910023855 dimerization interface [polypeptide binding]; other site 637910023856 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 637910023857 dimer interface [polypeptide binding]; other site 637910023858 putative CheW interface [polypeptide binding]; other site 637910023859 2 transmembrane helices predicted for ROD48461 by TMHMM2.0 at aa 7-29 and 192-214 637910023860 HMMPfam hit to PF02203, Ligand binding Tar, score 3.2e-52 637910023861 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 8.9e-18 637910023862 PS00538 Bacterial chemotaxis sensory transducers signature. 637910023863 HMMPfam hit to PF00015, Bacterial chemotaxis sensory transducer, score 8.9e-121 637910023864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910023865 D-galactonate transporter; Region: 2A0114; TIGR00893 637910023866 putative substrate translocation pore; other site 637910023867 11 transmembrane helices predicted for ROD48471 by TMHMM2.0 at aa 39-56, 72-93, 108-130, 169-191, 195-217, 258-280, 295-317, 330-349, 359-381, 393-415 and 421-443 637910023868 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 3.2e-71 637910023869 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 637910023871 DNA-binding site [nucleotide binding]; DNA binding site 637910023872 Transcriptional regulators [Transcription]; Region: GntR; COG1802 637910023873 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 637910023874 HMMPfam hit to PF07729, GntR, C-terminal, score 6.7e-05 637910023875 Predicted helix-turn-helix motif with score 2077.000, SD 6.26 at aa 29-50, sequence PSQSALAEMYNISRTTVRHILR 637910023876 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 0.00018 637910023877 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 637910023878 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 637910023879 putative NAD(P) binding site [chemical binding]; other site 637910023880 catalytic Zn binding site [ion binding]; other site 637910023881 structural Zn binding site [ion binding]; other site 637910023882 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 8.7e-53 637910023883 PS00059 Zinc-containing alcohol dehydrogenases signature. 637910023884 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 1.1e-36 637910023885 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 637910023886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910023887 Walker A motif; other site 637910023888 ATP binding site [chemical binding]; other site 637910023889 Walker B motif; other site 637910023890 arginine finger; other site 637910023891 Transcriptional antiterminator [Transcription]; Region: COG3933 637910023892 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 637910023893 active pocket/dimerization site; other site 637910023894 active site 637910023895 phosphorylation site [posttranslational modification] 637910023896 PRD domain; Region: PRD; pfam00874 637910023897 Predicted helix-turn-helix motif with score 1213.000, SD 3.32 at aa 26-47, sequence FTARYLAQRFAMQRNTASHYLN 637910023898 HMMPfam hit to PF00158, RNA polymerase sigma factor 54, interaction, score 6.9e-60 637910023899 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 637910023900 PS00017 ATP/GTP-binding site motif A (P-loop). 637910023901 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 637910023902 PS00690 DEAH-box subfamily ATP-dependent helicases signature. 637910023903 HMMPfam hit to PF00874, PRD, score 6.8e-14 637910023904 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 637910023905 active pocket/dimerization site; other site 637910023906 active site 637910023907 phosphorylation site [posttranslational modification] 637910023908 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 2.6e-13 637910023909 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 637910023910 active site 637910023911 phosphorylation site [posttranslational modification] 637910023912 HMMPfam hit to PF03830, Phosphotransferase system, sorbose subfamily IIB component, score 2.2e-45 637910023913 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 637910023914 HMMPfam hit to PF03609, Phosphotransferase system, sorbose-specific IIC subunit, score 1.7e-52 637910023915 7 transmembrane helices predicted for ROD48531 by TMHMM2.0 at aa 4-26, 33-55, 70-87, 92-114, 141-163, 176-198 and 213-235 637910023916 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 637910023917 HMMPfam hit to PF03613, Phosphotransferase system, mannose/fructose/sorbose family IID component, score 5.6e-70 637910023918 4 transmembrane helices predicted for ROD48541 by TMHMM2.0 at aa 69-91, 111-133, 146-168 and 197-219 637910023919 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 637910023920 HMMPfam hit to PF03613, Phosphotransferase system, mannose/fructose/sorbose family IID component, score 3.4e-10 637910023921 1 transmembrane helix predicted for ROD48551 by TMHMM2.0 at aa 23-42 637910023922 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 637910023923 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 637910023924 dimer interface [polypeptide binding]; other site 637910023925 active site 637910023926 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 637910023927 dimer interface [polypeptide binding]; other site 637910023928 active site 637910023929 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 4.9e-09 637910023930 PS00017 ATP/GTP-binding site motif A (P-loop). 637910023931 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 0.0038 637910023932 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 637910023933 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 637910023934 putative active site [active] 637910023935 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 637910023936 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 1.6e-10 637910023937 phosphoglycerol transferase I; Provisional; Region: PRK03776 637910023938 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 637910023939 HMMPfam hit to PF00884, Sulphatase, score 9.8e-17 637910023940 2 transmembrane helices predicted for ROD48581 by TMHMM2.0 at aa 43-65 and 72-94 637910023941 hypothetical protein; Provisional; Region: PRK11667 637910023942 1 transmembrane helix predicted for ROD48591 by TMHMM2.0 at aa 7-26 637910023943 DNA replication protein DnaC; Validated; Region: PRK07952 637910023944 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 637910023945 Walker A motif; other site 637910023946 ATP binding site [chemical binding]; other site 637910023947 Walker B motif; other site 637910023948 primosomal protein DnaI; Provisional; Region: PRK02854 637910023949 hypothetical protein; Provisional; Region: PRK09917 637910023950 4 transmembrane helices predicted for ROD48621 by TMHMM2.0 at aa 13-35, 58-80, 92-114 and 134-156 637910023951 Uncharacterized conserved protein [Function unknown]; Region: COG2966 637910023952 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 637910023953 4 transmembrane helices predicted for ROD48631 by TMHMM2.0 at aa 137-156, 169-191, 196-218 and 231-253 637910023954 HMMPfam hit to PF06738, Protein of unknown function DUF1212, score 2.1e-75 637910023955 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023956 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 637910023957 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 637910023958 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 637910023959 HMMPfam hit to PF01494, Monooxygenase, FAD-binding, score 1.6e-109 637910023960 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 637910023961 Cupin domain; Region: Cupin_2; cl17218 637910023962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910023963 HMMPfam hit to PF02311, AraC protein, arabinose-binding/dimerisation, score 0.00076 637910023964 Predicted helix-turn-helix motif with score 1488.000, SD 4.25 at aa 203-224, sequence LPLTEYARRVGLSANYLNQLCR 637910023965 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 3.3e-05 637910023966 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 637910023967 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910023968 DNA binding residues [nucleotide binding] 637910023969 dimerization interface [polypeptide binding]; other site 637910023970 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 1.4e-06 637910023971 Predicted helix-turn-helix motif with score 1056.000, SD 2.78 at aa 169-190, sequence WGINQIAMLLKKSNKTISAQKN 637910023972 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 637910023973 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 637910023974 DNA binding residues [nucleotide binding] 637910023975 dimerization interface [polypeptide binding]; other site 637910023976 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 3.5e-14 637910023977 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 637910023978 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 637910023979 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 637910023980 HMMPfam hit to PF06276, Ferric iron reductase, score 2.2e-128 637910023981 PS00294 Prenyl group binding site (CAAX box). 637910023982 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 637910023983 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 637910023984 metal binding site [ion binding]; metal-binding site 637910023985 active site 637910023986 I-site; other site 637910023987 HMMPfam hit to PF00990, GGDEF, score 7.7e-65 637910023988 5 transmembrane helices predicted for ROD48701 by TMHMM2.0 at aa 21-38, 43-62, 69-86, 101-123 and 144-163 637910023989 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910023990 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 637910023991 HMMPfam hit to PF07256, Protein of unknown function DUF1435, score 1e-46 637910023992 3 transmembrane helices predicted for ROD48711 by TMHMM2.0 at aa 47-66, 70-89 and 96-118 637910023993 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 637910023994 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 637910023995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910023996 S-adenosylmethionine binding site [chemical binding]; other site 637910023997 HMMPfam hit to PF05175, Methyltransferase small, score 5.4e-98 637910023998 PS00092 N-6 Adenine-specific DNA methylases signature. 637910023999 HMMPfam hit to PF08468, Methyltransferase small, N-terminal, score 1.5e-96 637910024000 DNA polymerase III subunit psi; Validated; Region: PRK06856 637910024001 HMMPfam hit to PF03603, DNA polymerase III subunit psi, score 8.8e-57 637910024002 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 637910024003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 637910024004 Coenzyme A binding pocket [chemical binding]; other site 637910024005 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2.1e-21 637910024006 dUMP phosphatase; Provisional; Region: PRK09449 637910024007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910024008 motif II; other site 637910024009 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 7.1e-29 637910024010 CR_GI14 637910024011 pseudogene, C-terminus deleted by ISEc14 insertion, N-terminal part truncated by premature stop codon 637910024012 putative transposase OrfB; Reviewed; Region: PHA02517 637910024013 HTH-like domain; Region: HTH_21; pfam13276 637910024014 Integrase core domain; Region: rve; pfam00665 637910024015 Integrase core domain; Region: rve_3; pfam13683 637910024016 HMMPfam hit to PF00665, Integrase, catalytic core, score 1.3e-45 637910024017 PS00501 Signal peptidases I serine active site. 637910024018 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910024019 Transposase; Region: HTH_Tnp_1; pfam01527 637910024020 HMMPfam hit to PF01527, Transposase IS3/IS911, score 5.2e-23 637910024021 Predicted helix-turn-helix motif with score 1681.000, SD 4.91 at aa 23-44, sequence YSVAEVSDRLGVSAHSLYKWLR 637910024022 pseudogene, C-terminus deleted by ISEc14 insertion; Intact copy of this transposase is found at ROD26381 637910024023 HMMPfam hit to PF00665, Integrase, catalytic core, score 7.8e-27 637910024024 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910024025 Homeodomain-like domain; Region: HTH_23; cl17451 637910024026 PS00017 ATP/GTP-binding site motif A (P-loop). 637910024027 pseudogene, C-terminus missing, missense mutation of the start codon, additionally fragmented by frameshift mutation and premature stop codon 637910024028 HMMPfam hit to PF08410, Region of unknown function DUF1737, score 3.1e-22 637910024029 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 637910024030 HMMPfam hit to PF06416, Protein of unknown function DUF1076, score 1.9e-63 637910024031 AvrPphF-ORF-2; Region: AvrPphF-ORF-2; pfam09143 637910024032 pseudogene, fragmented by premature stop codon and three frameshift mutations 637910024033 pseudogene, fragmented by four premature stop codons 637910024034 HMMPfam hit to PF00665, Integrase, catalytic core, score 2.5e-14 637910024035 pseudogene, truncated by two frameshift mutations 637910024036 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2.5e-21 637910024037 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 637910024038 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 637910024039 G1 box; other site 637910024040 putative GEF interaction site [polypeptide binding]; other site 637910024041 GTP/Mg2+ binding site [chemical binding]; other site 637910024042 Switch I region; other site 637910024043 G2 box; other site 637910024044 G3 box; other site 637910024045 Switch II region; other site 637910024046 G4 box; other site 637910024047 G5 box; other site 637910024048 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 637910024049 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 4.3e-60 637910024050 PS00301 GTP-binding elongation factors signature. 637910024051 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 4.2e-12 637910024052 periplasmic protein; Provisional; Region: PRK10568 637910024053 BON domain; Region: BON; pfam04972 637910024054 BON domain; Region: BON; pfam04972 637910024055 HMMPfam hit to PF04972, Transport-associated, score 4.4e-15 637910024056 HMMPfam hit to PF04972, Transport-associated, score 1.3e-14 637910024057 HMMPfam hit to PF07043, Protein of unknown function DUF1328, score 4.6e-23 637910024058 2 transmembrane helices predicted for ROD48991 by TMHMM2.0 at aa 5-23 and 27-49 637910024059 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 637910024060 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 637910024061 active site 637910024062 nucleophile elbow; other site 637910024063 HMMPfam hit to PF01734, Patatin, score 1.5e-27 637910024064 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 637910024065 active site 637910024066 HMMPfam hit to PF01026, Deoxyribonuclease, TatD-related, score 3e-96 637910024067 PS01137 Uncharacterized protein family UPF0006 signature 1. 637910024068 PS01090 Uncharacterized protein family UPF0006 signature 2. 637910024069 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 637910024070 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 637910024071 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910024072 FeS/SAM binding site; other site 637910024073 HMMPfam hit to PF04055, Radical SAM, score 2.4e-14 637910024074 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0036 637910024075 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910024076 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.00054 637910024077 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 637910024078 PS01087 Radical activating enzymes signature. 637910024079 PS00190 Cytochrome c family heme-binding site signature. 637910024080 hypothetical protein; Provisional; Region: PRK10977 637910024081 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 637910024082 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 637910024083 intersubunit interface [polypeptide binding]; other site 637910024084 active site 637910024085 catalytic residue [active] 637910024086 HMMPfam hit to PF01791, Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase, score 4.6e-83 637910024087 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 637910024088 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 637910024089 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 637910024090 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 637910024091 HMMPfam hit to PF02885, Glycosyl transferase, family 3, score 7.1e-26 637910024092 HMMPfam hit to PF00591, Glycosyl transferase, family 3, score 6.2e-85 637910024093 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024094 PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature. 637910024095 HMMPfam hit to PF07831, Pyrimidine nucleoside phosphorylase, C-terminal, score 2.7e-31 637910024096 phosphopentomutase; Provisional; Region: PRK05362 637910024097 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 637910024098 HMMPfam hit to PF08342, Phosphopentomutase N-terminal, score 3.5e-67 637910024099 HMMPfam hit to PF01676, Metalloenzyme, score 3.2e-47 637910024100 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 637910024101 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 637910024102 HMMPfam hit to PF01048, Nucleoside phosphorylase, score 9.2e-116 637910024103 PS01232 Purine and other phosphorylases family 1 signature. 637910024104 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 637910024105 hypothetical protein; Provisional; Region: PRK15303 637910024106 HMMPfam hit to PF06551, Protein of unknown function DUF1120, score 1.3e-68 637910024107 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 637910024108 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 637910024109 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 637910024110 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase, score 2.1e-20 637910024111 hypothetical protein; Provisional; Region: PRK11246 637910024112 2 transmembrane helices predicted for ROD49101 by TMHMM2.0 at aa 13-32 and 162-184 637910024113 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 637910024114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 637910024115 motif II; other site 637910024116 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.6e-26 637910024117 PS00041 Bacterial regulatory proteins, araC family signature. 637910024118 DNA repair protein RadA; Region: sms; TIGR00416 637910024119 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 637910024120 Walker A motif/ATP binding site; other site 637910024121 ATP binding site [chemical binding]; other site 637910024122 Walker B motif; other site 637910024123 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 637910024124 PS00190 Cytochrome c family heme-binding site signature. 637910024125 PS00017 ATP/GTP-binding site motif A (P-loop). 637910024126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637910024127 non-specific DNA binding site [nucleotide binding]; other site 637910024128 salt bridge; other site 637910024129 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 637910024130 sequence-specific DNA binding site [nucleotide binding]; other site 637910024131 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 637910024132 active site 637910024133 (T/H)XGH motif; other site 637910024134 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 637910024135 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 1.9e-10 637910024136 Predicted helix-turn-helix motif with score 1877.000, SD 5.58 at aa 16-37, sequence CTLQQVADASGMTKGYLSQLLN 637910024137 PS00017 ATP/GTP-binding site motif A (P-loop). 637910024138 PS00687 Aldehyde dehydrogenases glutamic acid active site. 637910024139 LysR family transcriptional regulator; Provisional; Region: PRK14997 637910024140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910024141 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 637910024142 putative effector binding pocket; other site 637910024143 dimerization interface [polypeptide binding]; other site 637910024144 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 9.2e-21 637910024145 Predicted helix-turn-helix motif with score 1635.000, SD 4.76 at aa 18-39, sequence GSFTAAAQKAGLPKSSVSQRIS 637910024146 PS00044 Bacterial regulatory proteins, lysR family signature. 637910024147 HMMPfam hit to PF03466, LysR, substrate-binding, score 1e-45 637910024148 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 637910024149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910024150 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 637910024151 putative dimerization interface [polypeptide binding]; other site 637910024152 HMMPfam hit to PF03466, LysR, substrate-binding, score 7.8e-06 637910024153 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 4e-18 637910024154 PS00044 Bacterial regulatory proteins, lysR family signature. 637910024155 Predicted helix-turn-helix motif with score 1987.000, SD 5.95 at aa 19-40, sequence RGFERAAQKLCITQSAVSQRIK 637910024156 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 637910024157 tetramer (dimer of dimers) interface [polypeptide binding]; other site 637910024158 active site 637910024159 dimer interface [polypeptide binding]; other site 637910024160 HMMPfam hit to PF06026, Ribose 5-phosphate isomerase, score 1.4e-99 637910024161 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 637910024162 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 637910024163 ligand binding site [chemical binding]; other site 637910024164 NAD binding site [chemical binding]; other site 637910024165 tetramer interface [polypeptide binding]; other site 637910024166 catalytic site [active] 637910024167 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 637910024168 L-serine binding site [chemical binding]; other site 637910024169 ACT domain interface; other site 637910024170 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region, score 1.6e-35 637910024171 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, score 1.9e-66 637910024172 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 637910024173 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 637910024174 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 637910024175 HMMPfam hit to PF01842, Amino acid-binding ACT, score 3.6e-09 637910024176 pseudogene, truncated by premature stop codon 637910024177 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 637910024178 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 637910024179 HMMPfam hit to PF01812, 5-formyltetrahydrofolate cyclo-ligase, score 1.2e-50 637910024180 Z-ring-associated protein; Provisional; Region: PRK10972 637910024181 HMMPfam hit to PF05164, Protein of unknown function DUF710, score 2.4e-36 637910024182 hypothetical protein; Reviewed; Region: PRK01736 637910024183 HMMPfam hit to PF03695, Protein of unknown function UPF0149, score 1.1e-119 637910024184 proline aminopeptidase P II; Provisional; Region: PRK10879 637910024185 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 637910024186 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 637910024187 active site 637910024188 HMMPfam hit to PF05195, Peptidase M24B, X-Pro dipeptidase/aminopeptidase P N-terminal, score 5.3e-68 637910024189 HMMPfam hit to PF00557, Peptidase M24, catalytic core, score 1.8e-115 637910024190 PS00491 Aminopeptidase P and proline dipeptidase signature. 637910024191 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 637910024192 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 637910024193 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.00013 637910024194 PS01304 ubiH/COQ6 monooxygenase family signature. 637910024195 oxidoreductase; Provisional; Region: PRK08013 637910024196 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 637910024197 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 4.3e-10 637910024198 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024199 HMMPfam hit to PF01494, Monooxygenase, FAD-binding, score 2.8e-14 637910024200 PS01304 ubiH/COQ6 monooxygenase family signature. 637910024201 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 637910024202 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 637910024203 HMMPfam hit to PF01571, Glycine cleavage T protein (aminomethyl transferase), score 1.6e-110 637910024204 HMMPfam hit to PF08669, Glycine cleavage T-protein, C-terminal barrel, score 2.6e-37 637910024205 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 637910024206 lipoyl attachment site [posttranslational modification]; other site 637910024207 HMMPfam hit to PF01597, Glycine cleavage H-protein, score 3.2e-75 637910024208 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 637910024209 glycine dehydrogenase; Provisional; Region: PRK05367 637910024210 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 637910024211 tetramer interface [polypeptide binding]; other site 637910024212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910024213 catalytic residue [active] 637910024214 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 637910024215 tetramer interface [polypeptide binding]; other site 637910024216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910024217 catalytic residue [active] 637910024218 HMMPfam hit to PF02347, Glycine cleavage system P-protein, score 2.8e-289 637910024219 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024220 pseudogene, truncated by frameshift mutation 637910024221 HMMPfam hit to PF00232, Glycoside hydrolase, family 1, score 4.5e-147 637910024222 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 637910024223 HMMPfam hit to PF06164, Uncharacterised conserved protein UCP029143, score 2.5e-70 637910024224 hemolysin; Provisional; Region: PRK15087 637910024225 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 637910024226 HMMPfam hit to PF03006, Hly-III related proteins, score 2.3e-66 637910024227 7 transmembrane helices predicted for ROD49341 by TMHMM2.0 at aa 20-42, 46-68, 89-107, 112-134, 139-161, 165-187 and 194-216 637910024228 putative global regulator; Reviewed; Region: PRK09559 637910024229 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 637910024230 hypothetical protein; Provisional; Region: PRK10878 637910024231 HMMPfam hit to PF03937, Protein of unknown function DUF339, score 1.6e-42 637910024232 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 637910024233 HMMPfam hit to PF07254, Protein of unknown function DUF1434, score 5.2e-97 637910024234 1 transmembrane helix predicted for ROD49371 by TMHMM2.0 at aa 29-51 637910024235 flavodoxin FldB; Provisional; Region: PRK12359 637910024236 HMMPfam hit to PF00258, Flavodoxin/nitric oxide synthase, score 2e-41 637910024237 PS00201 Flavodoxin signature. 637910024238 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 637910024239 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 637910024240 active site 637910024241 Int/Topo IB signature motif; other site 637910024242 HMMPfam hit to PF02899, Integrase, N-terminal SAM-like, phage, score 8.8e-30 637910024243 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 6.2e-74 637910024244 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 637910024245 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 637910024246 dimerization domain [polypeptide binding]; other site 637910024247 dimer interface [polypeptide binding]; other site 637910024248 catalytic residues [active] 637910024249 PS00194 Thioredoxin family active site. 637910024250 PS00190 Cytochrome c family heme-binding site signature. 637910024251 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 637910024252 DHH family; Region: DHH; pfam01368 637910024253 DHHA1 domain; Region: DHHA1; pfam02272 637910024254 HMMPfam hit to PF01368, Phosphoesterase, RecJ-like, score 3.8e-53 637910024255 HMMPfam hit to PF02272, Phosphoesterase, DHHA1, score 3.3e-17 637910024256 peptide chain release factor 2; Validated; Region: prfB; PRK00578 637910024257 This domain is found in peptide chain release factors; Region: PCRF; smart00937 637910024258 RF-1 domain; Region: RF-1; pfam00472 637910024259 HMMPfam hit to PF03462, PCRF, score 5.3e-60 637910024260 HMMPfam hit to PF00472, Class I peptide chain release factor, score 1.4e-74 637910024261 PS00745 Prokaryotic-type class I peptide chain release factors signature. 637910024262 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 637910024263 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 637910024264 dimer interface [polypeptide binding]; other site 637910024265 putative anticodon binding site; other site 637910024266 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 637910024267 motif 1; other site 637910024268 active site 637910024269 motif 2; other site 637910024270 motif 3; other site 637910024271 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 3.9e-20 637910024272 HMMPfam hit to PF00152, Aminoacyl-tRNA synthetase, class II (D, K and N), score 1.1e-131 637910024273 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 637910024274 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 637910024275 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 637910024276 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 637910024277 active site 637910024278 metal binding site [ion binding]; metal-binding site 637910024279 nudix motif; other site 637910024280 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 6.1e-13 637910024281 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024282 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 637910024283 Peptidase family M23; Region: Peptidase_M23; pfam01551 637910024284 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024285 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 4.8e-19 637910024286 HMMPfam hit to PF01551, Peptidase M23B, score 1.8e-52 637910024287 CR_GI15 637910024288 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637910024289 active site 637910024290 DNA binding site [nucleotide binding] 637910024291 Int/Topo IB signature motif; other site 637910024292 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 2.4e-10 637910024293 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 637910024294 3 transmembrane helices predicted for ROD49472 by TMHMM2.0 at aa 21-43, 58-77 and 84-106 637910024295 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024296 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 637910024297 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 637910024298 catalytic residues [active] 637910024299 catalytic nucleophile [active] 637910024300 Presynaptic Site I dimer interface [polypeptide binding]; other site 637910024301 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 637910024302 Synaptic Flat tetramer interface [polypeptide binding]; other site 637910024303 Synaptic Site I dimer interface [polypeptide binding]; other site 637910024304 DNA binding site [nucleotide binding] 637910024305 HMMPfam hit to PF00239, Resolvase, N-terminal, score 1.3e-56 637910024306 PS00397 Site-specific recombinases active site. 637910024307 PS00398 Site-specific recombinases signature 2. 637910024308 HMMPfam hit to PF02796, Resolvase, helix-turn-helix region, score 1.1e-06 637910024309 Predicted helix-turn-helix motif with score 1328.000, SD 3.71 at aa 169-190, sequence LSADQIAKLAGCGRATVFRIKK 637910024310 pseudogene, C-terminus missing, N-terminal part fragmented by three frameshift mutations 637910024311 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 637910024312 pseudogene, C-terminus missing, N-terminal part truncated by frameshift mutation 637910024313 CR_GI16 637910024314 pseudogene, truncated by premature stop codon 637910024315 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 637910024316 HMMPfam hit to PF06117, Protein of unknown function DUF957, enterobacteria, score 1e-47 637910024317 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 637910024318 HMMPfam hit to PF06755, Protein of unknown function DUF1219, score 9.7e-104 637910024319 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 637910024320 HMMPfam hit to PF06154, YagBYeeUYfjZ, score 1.5e-84 637910024321 Protein of unknown function (DUF987); Region: DUF987; pfam06174 637910024322 HMMPfam hit to PF06174, Protein of unknown function DUF987, score 4.1e-56 637910024323 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 637910024324 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 637910024325 MPN+ (JAMM) motif; other site 637910024326 Zinc-binding site [ion binding]; other site 637910024327 HMMPfam hit to PF04002, DNA repair protein RadC, score 1.7e-82 637910024328 PS01302 DNA repair protein radC family signature. 637910024329 Antirestriction protein; Region: Antirestrict; pfam03230 637910024330 HMMPfam hit to PF03230, Antirestriction protein, score 6.9e-51 637910024331 Domain of unknown function (DUF932); Region: DUF932; pfam06067 637910024332 HMMPfam hit to PF06067, Protein of unknown function DUF932, score 1.7e-217 637910024333 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 637910024334 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 637910024335 hypothetical protein; Provisional; Region: PRK09945 637910024336 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 637910024337 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637910024338 Autotransporter beta-domain; Region: Autotransporter; smart00869 637910024339 HMMPfam hit to PF03797, Autotransporter beta-domain, score 2.4e-31 637910024340 HMMPfam hit to PF03212, Pertactin, score 5e-05 637910024341 PS00017 ATP/GTP-binding site motif A (P-loop). 637910024342 Predicted GTPase [General function prediction only]; Region: COG3596 637910024343 YfjP GTPase; Region: YfjP; cd11383 637910024344 G1 box; other site 637910024345 GTP/Mg2+ binding site [chemical binding]; other site 637910024346 Switch I region; other site 637910024347 G2 box; other site 637910024348 Switch II region; other site 637910024349 G3 box; other site 637910024350 G4 box; other site 637910024351 G5 box; other site 637910024352 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 3.5e-20 637910024353 PS00017 ATP/GTP-binding site motif A (P-loop). 637910024354 Replication regulatory protein RepB; Region: RepB-RCR_reg; cl11673 637910024355 1 transmembrane helix predicted for ROD49771 by TMHMM2.0 at aa 10-32 637910024356 PS00818 Dps protein family signature 1. 637910024357 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 637910024358 HMMPfam hit to PF05930, Prophage CP4-57 regulatory, score 2.2e-22 637910024359 Haemolysin expression modulating protein; Region: HHA; pfam05321 637910024360 HMMPfam hit to PF05321, Haemolysin expression modulating, score 1.9e-29 637910024361 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 637910024362 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 637910024363 PS00190 Cytochrome c family heme-binding site signature. 637910024364 PS00190 Cytochrome c family heme-binding site signature. 637910024365 pseudogene, truncated by frameshift mutation 637910024366 Transposase; Region: HTH_Tnp_1; cl17663 637910024367 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910024368 HMMPfam hit to PF01527, Transposase IS3/IS911, score 6.2e-08 637910024369 Predicted helix-turn-helix motif with score 1285.000, SD 3.56 at aa 33-54, sequence IGVTAAARELSLYESQLYNWRS 637910024370 putative transposase OrfB; Reviewed; Region: PHA02517 637910024371 HTH-like domain; Region: HTH_21; pfam13276 637910024372 Integrase core domain; Region: rve; pfam00665 637910024373 Integrase core domain; Region: rve_2; pfam13333 637910024374 HMMPfam hit to PF00665, Integrase, catalytic core, score 8.5e-50 637910024375 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 637910024376 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 637910024377 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 637910024378 HMMPfam hit to PF08479, Polypeptide-transport-associated, ShlB-type, score 2.3e-31 637910024379 HMMPfam hit to PF03865, Hemolysin activator HlyB, score 2.2e-13 637910024380 RTX toxin acyltransferase family; Region: HlyC; pfam02794 637910024381 HMMPfam hit to PF02794, Bacterial RTX toxin-activating protein C, score 3.8e-16 637910024382 haemagglutination activity domain; Region: Haemagg_act; pfam05860 637910024383 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 637910024384 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 637910024385 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637910024386 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637910024387 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 637910024388 HMMPfam hit to PF05860, Filamentous haemagglutinin, N-terminal, bacterial, score 7.5e-52 637910024389 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024390 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 4.2e-06 637910024391 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.0014 637910024392 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 5e-05 637910024393 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.00079 637910024394 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 4.8e-07 637910024395 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 4.2e-07 637910024396 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.52 637910024397 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.0013 637910024398 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 1.9 637910024399 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.00012 637910024400 Predicted helix-turn-helix motif with score 980.000, SD 2.52 at aa 1237-1258, sequence GTGRIYGDAVGVSAATFYNLEE 637910024401 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.71 637910024402 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 0.13 637910024403 HMMPfam hit to PF05594, Filamentous haemagglutinin, bacterial, score 2.4 637910024404 PS00017 ATP/GTP-binding site motif A (P-loop). 637910024405 4 transmembrane helices predicted for ROD49951 by TMHMM2.0 at aa 13-35, 55-77, 84-103 and 129-151 637910024406 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024407 Xylella fastidiosa protein of unknown function (DUF769); Region: DUF769; pfam05590 637910024408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3792 637910024409 HMMPfam hit to PF04591, Protein of unknown function DUF596, score 4.3e-25 637910024410 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 637910024411 HMMPfam hit to PF06316, Virulence-related outer membrane protein, score 1.4e-16 637910024412 PS00695 Enterobacterial virulence outer membrane protein signature 2. 637910024413 Nuclease-related domain; Region: NERD; pfam08378 637910024414 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 637910024415 Part of AAA domain; Region: AAA_19; pfam13245 637910024416 Family description; Region: UvrD_C_2; pfam13538 637910024417 PS00017 ATP/GTP-binding site motif A (P-loop). 637910024418 HMMPfam hit to PF00580, DNA helicase, UvrD/REP type, score 2.6e-06 637910024419 Pseudogene, truncated by premature stop codon 637910024420 HMMPfam hit to PF06812, ImpA, N-terminal, score 6.8e-19 637910024421 1 transmembrane helix predicted for ROD50031 by TMHMM2.0 at aa 234-256 637910024422 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 637910024423 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 637910024424 HMMPfam hit to PF07693, KAP P-loop, score 1.9e-133 637910024425 PS00017 ATP/GTP-binding site motif A (P-loop). 637910024426 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 637910024427 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024428 Predicted helix-turn-helix motif with score 1089.000, SD 2.90 at aa 286-307, sequence TSIQKIFDALGISCQIINPYQF 637910024429 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 637910024430 active site 637910024431 HMMPfam hit to PF01026, Deoxyribonuclease, TatD-related, score 2.9e-34 637910024432 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910024433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910024434 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910024435 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910024436 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910024437 HMMPfam hit to PF03050, Transposase, IS66, score 2.2e-126 637910024438 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910024439 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910024440 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 8e-68 637910024441 Transposase; Region: HTH_Tnp_1; pfam01527 637910024442 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910024443 HMMPfam hit to PF01527, Transposase IS3/IS911, score 8.4e-28 637910024444 2 transmembrane helices predicted for ROD50141 by TMHMM2.0 at aa 30-52 and 56-77 637910024445 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 637910024446 active site 637910024447 NTP binding site [chemical binding]; other site 637910024448 metal binding triad [ion binding]; metal-binding site 637910024449 pseudogene, N-terminus missing, probably deleted by ISCro1 insertion 637910024450 pseudogene, N-terminus missing, fragment 637910024451 pseudogene, N-terminus deleted by ISCro1 insertion 637910024452 HMMPfam hit to PF01609, Transposase, IS4-like, score 6.9e-08 637910024453 pseudogene, N-terminus missing, fragment 637910024454 integrase; Provisional; Region: PRK09692 637910024455 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 637910024456 active site 637910024457 Int/Topo IB signature motif; other site 637910024458 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 1.8e-22 637910024459 Protein of unknown function (DUF554); Region: DUF554; pfam04474 637910024460 HMMPfam hit to PF04474, Protein of unknown function DUF554, score 1.6e-115 637910024461 6 transmembrane helices predicted for ROD50211 by TMHMM2.0 at aa 4-23, 36-58, 102-124, 145-167, 177-199 and 211-233 637910024462 ornithine decarboxylase; Provisional; Region: PRK13578 637910024463 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 637910024464 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 637910024465 homodimer interface [polypeptide binding]; other site 637910024466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 637910024467 catalytic residue [active] 637910024468 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 637910024469 HMMPfam hit to PF03709, Orn/Lys/Arg decarboxylase, N-terminal, score 1.2e-29 637910024470 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase, major region, score 0 637910024471 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024472 PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. 637910024473 HMMPfam hit to PF03711, Orn/Lys/Arg decarboxylase, C-terminal, score 2e-85 637910024474 nucleoside transporter; Region: 2A0110; TIGR00889 637910024475 HMMPfam hit to PF03825, Nucleoside:H+ symporter, score 2.8e-279 637910024476 12 transmembrane helices predicted for ROD50231 by TMHMM2.0 at aa 9-31, 41-63, 70-87, 92-114, 135-152, 162-184, 211-233, 253-275, 282-301, 311-333, 346-365 and 380-402 637910024477 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024478 murein transglycosylase C; Provisional; Region: mltC; PRK11671 637910024479 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 637910024480 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637910024481 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637910024482 catalytic residue [active] 637910024483 HMMPfam hit to PF01464, Lytic transglycosylase-like, catalytic, score 4e-43 637910024484 PS00922 Prokaryotic transglycosylases signature. 637910024485 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024486 oxidative damage protection protein; Provisional; Region: PRK05408 637910024487 HMMPfam hit to PF04362, Fe(II) trafficking protein YggX, score 1.9e-60 637910024488 adenine DNA glycosylase; Provisional; Region: PRK10880 637910024489 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 637910024490 minor groove reading motif; other site 637910024491 helix-hairpin-helix signature motif; other site 637910024492 substrate binding pocket [chemical binding]; other site 637910024493 active site 637910024494 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 637910024495 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 637910024496 DNA binding and oxoG recognition site [nucleotide binding] 637910024497 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024498 PS00764 Endonuclease III iron-sulfur binding region signature. 637910024499 HMMPfam hit to PF00730, HhH-GPD, score 4.3e-24 637910024500 PS01155 Endonuclease III family signature. 637910024501 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 2.4e-07 637910024502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 637910024503 S-adenosylmethionine binding site [chemical binding]; other site 637910024504 HMMPfam hit to PF02390, methyltransferase, score 6.1e-101 637910024505 hypothetical protein; Provisional; Region: PRK11702 637910024506 HMMPfam hit to PF04320, Protein of unknown function DUF469, score 6.3e-85 637910024507 hypothetical protein; Provisional; Region: PRK10626 637910024508 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 637910024509 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 637910024510 homodimer interface [polypeptide binding]; other site 637910024511 active site 637910024512 1 transmembrane helix predicted for ROD50301 by TMHMM2.0 at aa 7-29 637910024513 HMMPfam hit to PF00710, Asparaginase/glutaminase, score 2e-163 637910024514 PS00144 Asparaginase / glutaminase active site signature 1. 637910024515 PS00917 Asparaginase / glutaminase active site signature 2. 637910024516 HemN family oxidoreductase; Provisional; Region: PRK05660 637910024517 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 637910024518 FeS/SAM binding site; other site 637910024519 HemN C-terminal domain; Region: HemN_C; pfam06969 637910024520 HMMPfam hit to PF06969, HemN, C-terminal, score 5.4e-23 637910024521 Predicted helix-turn-helix motif with score 1286.000, SD 3.57 at aa 322-343, sequence APRREFSDYTGLSETAIRQQID 637910024522 HMMPfam hit to PF04055, Radical SAM, score 4.5e-27 637910024523 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 637910024524 active site 637910024525 dimerization interface [polypeptide binding]; other site 637910024526 HMMPfam hit to PF01725, Ham1-like protein, score 8.7e-114 637910024527 hypothetical protein; Validated; Region: PRK05090 637910024528 HMMPfam hit to PF02594, Protein of unknown function DUF167, score 2.8e-37 637910024529 YGGT family; Region: YGGT; pfam02325 637910024530 YGGT family; Region: YGGT; pfam02325 637910024531 HMMPfam hit to PF02325, Protein of unknown function YGGT, score 8.2e-29 637910024532 4 transmembrane helices predicted for ROD50341 by TMHMM2.0 at aa 5-27, 65-87, 94-116 and 144-166 637910024533 HMMPfam hit to PF02325, Protein of unknown function YGGT, score 8.9e-32 637910024534 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 637910024535 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637910024536 catalytic residue [active] 637910024537 HMMPfam hit to PF01168, Alanine racemase, N-terminal, score 1e-33 637910024538 PS01211 Uncharacterized protein family UPF0001 signature. 637910024539 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 637910024540 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 637910024541 Walker A motif; other site 637910024542 ATP binding site [chemical binding]; other site 637910024543 Walker B motif; other site 637910024544 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 6.2e-22 637910024545 PS00017 ATP/GTP-binding site motif A (P-loop). 637910024546 PS00662 Bacterial type II secretion system protein E signature. 637910024547 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 637910024548 HMMPfam hit to PF03652, Resolvase, holliday junction-type, YqgF-like, score 3.3e-55 637910024549 hypothetical protein; Validated; Region: PRK00228 637910024550 HMMPfam hit to PF02622, Protein of unknown function DUF179, score 3.9e-105 637910024551 glutathione synthetase; Provisional; Region: PRK05246 637910024552 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 637910024553 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 637910024554 HMMPfam hit to PF02955, Prokaryotic glutathione synthetase, ATP-binding, score 3.7e-129 637910024555 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 637910024556 HMMPfam hit to PF02951, Prokaryotic glutathione synthetase, N-terminal, score 1.3e-75 637910024557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 637910024558 RNA methyltransferase, RsmE family; Region: TIGR00046 637910024559 HMMPfam hit to PF04452, Protein of unknown function DUF558, methyltransferase predicted, score 4.1e-100 637910024560 PS00215 Mitochondrial energy transfer proteins signature. 637910024561 DNA-specific endonuclease I; Provisional; Region: PRK15137 637910024562 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 637910024563 HMMPfam hit to PF04231, Endonuclease I, score 2.8e-133 637910024564 hypothetical protein; Provisional; Region: PRK04860 637910024565 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 637910024566 HMMPfam hit to PF03926, Protein of unknown function DUF335, SprT, score 5.3e-86 637910024567 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 637910024568 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 637910024569 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637910024570 dimer interface [polypeptide binding]; other site 637910024571 phosphorylation site [posttranslational modification] 637910024572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910024573 ATP binding site [chemical binding]; other site 637910024574 Mg2+ binding site [ion binding]; other site 637910024575 G-X-G motif; other site 637910024576 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 7.9e-24 637910024577 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 9.1e-14 637910024578 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 2.9e-08 637910024579 2 transmembrane helices predicted for ROD50431 by TMHMM2.0 at aa 10-30 and 162-181 637910024580 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024581 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 637910024582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910024583 active site 637910024584 phosphorylation site [posttranslational modification] 637910024585 intermolecular recognition site; other site 637910024586 dimerization interface [polypeptide binding]; other site 637910024587 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637910024588 DNA binding site [nucleotide binding] 637910024589 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 4.8e-23 637910024590 HMMPfam hit to PF00072, Response regulator receiver, score 5.1e-40 637910024591 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 637910024592 active site 637910024593 homotetramer interface [polypeptide binding]; other site 637910024594 1 transmembrane helix predicted for ROD50451 by TMHMM2.0 at aa 12-34 637910024595 HMMPfam hit to PF00576, Transthyretin, score 2e-62 637910024596 PS00768 Transthyretin signature 1. 637910024597 PS00769 Transthyretin signature 2. 637910024598 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 637910024599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910024600 putative substrate translocation pore; other site 637910024601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910024602 HMMPfam hit to PF00083, General substrate transporter score 2e-184 637910024603 12 transmembrane helices predicted for ROD50461 by TMHMM2.0 at aa 13-35, 55-77, 84-103, 108-130, 142-159, 169-191, 252-274, 289-311, 318-340, 350-372, 385-407 and 417-436 637910024604 PS00216 Sugar transport proteins signature 1. 637910024605 PS00217 Sugar transport proteins signature 2. 637910024606 S-adenosylmethionine synthetase; Validated; Region: PRK05250 637910024607 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 637910024608 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 637910024609 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 637910024610 HMMPfam hit to PF02773, S-adenosylmethionine synthetase, score 1.6e-98 637910024611 PS00377 S-adenosylmethionine synthetase signature 2. 637910024612 HMMPfam hit to PF02772, S-adenosylmethionine synthetase, score 9.5e-84 637910024613 PS00376 S-adenosylmethionine synthetase signature 1. 637910024614 HMMPfam hit to PF00438, S-adenosylmethionine synthetase, score 3.6e-63 637910024615 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 637910024616 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 637910024617 dimer interface [polypeptide binding]; other site 637910024618 active site 637910024619 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 637910024620 catalytic residues [active] 637910024621 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 637910024622 HMMPfam hit to PF02784, Orn/DAP/Arg decarboxylase 2, score 1.5e-115 637910024623 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 637910024624 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 637910024625 HMMPfam hit to PF00278, Orn/DAP/Arg decarboxylase 2, score 4.9e-41 637910024626 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 637910024627 agmatinase; Region: agmatinase; TIGR01230 637910024628 oligomer interface [polypeptide binding]; other site 637910024629 putative active site [active] 637910024630 Mn binding site [ion binding]; other site 637910024631 HMMPfam hit to PF00491, Ureohydrolase, score 3.5e-138 637910024632 PS00147 Arginase family signature 1. 637910024633 PS00148 Arginase family signature 2. 637910024634 PS01053 Arginase family signature 3. 637910024635 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 637910024636 HMMPfam hit to PF01435, Peptidase M48, Ste24p, score 7.1e-30 637910024637 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024638 transketolase; Reviewed; Region: PRK12753 637910024639 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637910024640 TPP-binding site [chemical binding]; other site 637910024641 dimer interface [polypeptide binding]; other site 637910024642 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637910024643 PYR/PP interface [polypeptide binding]; other site 637910024644 dimer interface [polypeptide binding]; other site 637910024645 TPP binding site [chemical binding]; other site 637910024646 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637910024647 HMMPfam hit to PF00456, Transketolase, N-terminal, score 3.7e-257 637910024648 PS00801 Transketolase signature 1. 637910024649 HMMPfam hit to PF02779, Transketolase, central region, score 1.1e-68 637910024650 PS00802 Transketolase signature 2. 637910024651 HMMPfam hit to PF02780, Transketolase, C-terminal, score 1.8e-15 637910024652 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 637910024653 substrate binding site [chemical binding]; other site 637910024654 dimer interface [polypeptide binding]; other site 637910024655 triosephosphate isomerase; Provisional; Region: PRK14565 637910024656 catalytic triad [active] 637910024657 HMMPfam hit to PF00121, Triosephosphate isomerase, score 1.9e-113 637910024658 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 637910024659 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 637910024660 HMMPfam hit to PF04166, Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA, score 8.9e-98 637910024661 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 637910024662 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 637910024663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 637910024664 HMMPfam hit to PF03612, Sorbitol phosphotransferase enzyme II, N-terminal, score 7.5e-54 637910024665 HMMPfam hit to PF07005, type III effector Hrp-dependent outers, score 4.9e-05 637910024666 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 637910024667 HMMPfam hit to PF03812, 2-keto-3-deoxygluconate permease, score 7.5e-30 637910024668 10 transmembrane helices predicted for ROD50561 by TMHMM2.0 at aa 12-31, 41-63, 76-98, 103-125, 138-160, 165-184, 191-213, 223-245, 250-272 and 282-304 637910024669 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024670 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 637910024671 HMMPfam hit to PF03829, Phosphotransferase system, glucitol/sorbitol-specific IIA component, score 7.3e-37 637910024672 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 637910024673 HMMPfam hit to PF02502, Ribose/galactose isomerase, score 1e-76 637910024674 transaldolase-like protein; Provisional; Region: PTZ00411 637910024675 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 637910024676 active site 637910024677 dimer interface [polypeptide binding]; other site 637910024678 catalytic residue [active] 637910024679 HMMPfam hit to PF00923, Transaldolase, score 5.3e-156 637910024680 PS01054 Transaldolase signature 1. 637910024681 PS00958 Transaldolase active site. 637910024682 transketolase; Reviewed; Region: PRK12753 637910024683 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 637910024684 TPP-binding site [chemical binding]; other site 637910024685 dimer interface [polypeptide binding]; other site 637910024686 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 637910024687 PYR/PP interface [polypeptide binding]; other site 637910024688 dimer interface [polypeptide binding]; other site 637910024689 TPP binding site [chemical binding]; other site 637910024690 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 637910024691 HMMPfam hit to PF00456, Transketolase, N-terminal, score 2.2e-255 637910024692 PS00801 Transketolase signature 1. 637910024693 HMMPfam hit to PF02779, Transketolase, central region, score 1.1e-68 637910024694 PS00802 Transketolase signature 2. 637910024695 HMMPfam hit to PF02780, Transketolase, C-terminal, score 4.3e-13 637910024696 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 637910024697 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 1.8e-20 637910024698 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 637910024699 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637910024700 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637910024701 1 transmembrane helix predicted for ROD50621 by TMHMM2.0 at aa 7-29 637910024702 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 1e-33 637910024703 PS00635 Gram-negative pili assembly chaperone signature. 637910024704 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 3.4e-08 637910024705 pseudogene, C-terminus deleted by IS102 insertion 637910024706 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 637910024707 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910024708 HMMPfam hit to PF01609, Transposase, IS4-like, score 9.3e-30 637910024709 pseudogene, N-terminus deleted by IS102 insertion 637910024710 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 637910024711 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 637910024712 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, score 3.6e-82 637910024713 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 637910024714 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, score 3.9e-45 637910024715 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 637910024716 Phosphoglycerate kinase; Region: PGK; pfam00162 637910024717 substrate binding site [chemical binding]; other site 637910024718 hinge regions; other site 637910024719 ADP binding site [chemical binding]; other site 637910024720 catalytic site [active] 637910024721 HMMPfam hit to PF00162, Phosphoglycerate kinase, score 2.2e-134 637910024722 PS00111 Phosphoglycerate kinase signature. 637910024723 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 637910024724 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 637910024725 active site 637910024726 intersubunit interface [polypeptide binding]; other site 637910024727 zinc binding site [ion binding]; other site 637910024728 Na+ binding site [ion binding]; other site 637910024729 HMMPfam hit to PF01116, Ketose-bisphosphate aldolase, class-II, score 1.7e-212 637910024730 PS00602 Fructose-bisphosphate aldolase class-II signature 1. 637910024731 PS00806 Fructose-bisphosphate aldolase class-II signature 2. 637910024732 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 637910024733 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 637910024734 putative substrate binding site [chemical binding]; other site 637910024735 nucleotide binding site [chemical binding]; other site 637910024736 nucleotide binding site [chemical binding]; other site 637910024737 homodimer interface [polypeptide binding]; other site 637910024738 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 6.3e-79 637910024739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 637910024740 D-galactonate transporter; Region: 2A0114; TIGR00893 637910024741 putative substrate translocation pore; other site 637910024742 11 transmembrane helices predicted for ROD50701 by TMHMM2.0 at aa 15-34, 51-73, 88-110, 148-170, 180-198, 226-248, 263-280, 293-312, 317-339, 352-374 and 384-402 637910024743 HMMPfam hit to PF07690, major facilitator superfamily MFS-1, score 1.5e-71 637910024744 PS00217 Sugar transport proteins signature 2. 637910024745 membrane protein FdrA; Validated; Region: PRK06091 637910024746 CoA binding domain; Region: CoA_binding; pfam02629 637910024747 CoA-ligase; Region: Ligase_CoA; pfam00549 637910024748 HMMPfam hit to PF06263, Bacterial FdrA, score 2e-275 637910024749 PS00211 ABC transporters family signature. 637910024750 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 637910024751 HMMPfam hit to PF06545, Protein of unknown function DUF1116, score 6.5e-279 637910024752 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 637910024753 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024754 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 637910024755 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 637910024756 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 637910024757 dimerization interface [polypeptide binding]; other site 637910024758 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 4.7e-19 637910024759 Predicted helix-turn-helix motif with score 1149.000, SD 3.10 at aa 17-38, sequence ESFSRAASSLHKTPAAISYRIK 637910024760 HMMPfam hit to PF03466, LysR, substrate-binding, score 8.9e-16 637910024761 mechanosensitive channel MscS; Provisional; Region: PRK10334 637910024762 Mechanosensitive ion channel; Region: MS_channel; pfam00924 637910024763 HMMPfam hit to PF05552, Conserved TM helix, score 8.9e-15 637910024764 3 transmembrane helices predicted for ROD50751 by TMHMM2.0 at aa 23-45, 65-87 and 94-116 637910024765 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 1.4e-86 637910024766 PS01246 Uncharacterized protein family UPF0003 signature. 637910024767 arginine exporter protein; Provisional; Region: PRK09304 637910024768 6 transmembrane helices predicted for ROD50761 by TMHMM2.0 at aa 4-26, 39-61, 66-88, 111-133, 148-170 and 182-199 637910024769 HMMPfam hit to PF01810, Lysine exporter protein (LYSE/YGGA), score 5.9e-75 637910024770 Uncharacterized conserved protein [Function unknown]; Region: COG2968 637910024771 oxidative stress defense protein; Provisional; Region: PRK11087 637910024772 HMMPfam hit to PF04402, Protein of unknown function DUF541, score 1.4e-84 637910024773 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 637910024774 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637910024775 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637910024776 ABC transporter; Region: ABC_tran_2; pfam12848 637910024777 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 637910024778 HMMPfam hit to PF00005, ABC transporter related, score 1.6e-55 637910024779 PS00017 ATP/GTP-binding site motif A (P-loop). 637910024780 HMMPfam hit to PF00005, ABC transporter related, score 9.4e-61 637910024781 PS00211 ABC transporters family signature. 637910024782 PS00017 ATP/GTP-binding site motif A (P-loop). 637910024783 lytic murein transglycosylase; Provisional; Region: PRK11619 637910024784 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637910024785 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637910024786 catalytic residue [active] 637910024787 HMMPfam hit to PF01464, Lytic transglycosylase-like, catalytic, score 2.5e-45 637910024788 PS00922 Prokaryotic transglycosylases signature. 637910024789 Trp operon repressor; Provisional; Region: PRK01381 637910024790 HMMPfam hit to PF01371, Trp repressor, score 1.2e-41 637910024791 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 637910024792 HMMPfam hit to PF01931, Protein of unknown function DUF84, score 4.4e-102 637910024793 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 637910024794 catalytic core [active] 637910024795 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 5.1e-49 637910024796 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 637910024797 1 transmembrane helix predicted for ROD50821 by TMHMM2.0 at aa 146-168 637910024798 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024799 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 637910024800 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 637910024801 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 637910024802 HMMPfam hit to PF06445, Bacterial transcription activator, effector binding, score 5.5e-24 637910024803 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 3.3e-09 637910024804 PS00041 Bacterial regulatory proteins, araC family signature. 637910024805 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.3e-11 637910024806 Predicted helix-turn-helix motif with score 1159.000, SD 3.13 at aa 22-43, sequence LSLDNVAAKAGYSKWHLQRMFK 637910024807 hypothetical protein; Provisional; Region: PRK10756 637910024808 CreA protein; Region: CreA; pfam05981 637910024809 HMMPfam hit to PF05981, CreA, score 3.9e-95 637910024810 DNA-binding response regulator CreB; Provisional; Region: PRK11083 637910024811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910024812 active site 637910024813 phosphorylation site [posttranslational modification] 637910024814 intermolecular recognition site; other site 637910024815 dimerization interface [polypeptide binding]; other site 637910024816 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637910024817 DNA binding site [nucleotide binding] 637910024818 HMMPfam hit to PF00072, Response regulator receiver, score 6e-39 637910024819 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 6.3e-22 637910024820 sensory histidine kinase CreC; Provisional; Region: PRK11100 637910024821 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 637910024822 dimerization interface [polypeptide binding]; other site 637910024823 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 637910024824 dimer interface [polypeptide binding]; other site 637910024825 phosphorylation site [posttranslational modification] 637910024826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 637910024827 ATP binding site [chemical binding]; other site 637910024828 Mg2+ binding site [ion binding]; other site 637910024829 G-X-G motif; other site 637910024830 2 transmembrane helices predicted for ROD50861 by TMHMM2.0 at aa 5-27 and 184-206 637910024831 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 4.7e-13 637910024832 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 6.2e-15 637910024833 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 2.3e-34 637910024834 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 637910024835 HMMPfam hit to PF06123, Inner membrane CreD, score 1.5e-250 637910024836 6 transmembrane helices predicted for ROD50871 by TMHMM2.0 at aa 10-32, 298-317, 321-343, 350-372, 377-396 and 401-420 637910024837 two-component response regulator; Provisional; Region: PRK11173 637910024838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 637910024839 active site 637910024840 phosphorylation site [posttranslational modification] 637910024841 intermolecular recognition site; other site 637910024842 dimerization interface [polypeptide binding]; other site 637910024843 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 637910024844 DNA binding site [nucleotide binding] 637910024845 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 3.6e-18 637910024846 HMMPfam hit to PF00072, Response regulator receiver, score 3.9e-38 637910024847 putative RNA methyltransferase; Provisional; Region: PRK10433 637910024848 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase, SpoU, score 4e-15 637910024849 replication protein; Provisional; Region: PRK13702 637910024850 loop 637910024851 leader peptide RepL; Provisional; Region: PRK13716 637910024852 HMMPfam hit to PF08048, Tap RepA1 leader peptide, score 1.9e-08 637910024853 replication protein; Provisional; Region: PRK13750 637910024854 HMMPfam hit to PF02387, Plasmid replication initiation, RepA, score 9.2e-08 637910024855 CAAX protease self-immunity; Region: Abi; pfam02517 637910024856 6 probable transmembrane helices predicted for ROD_p1041 by TMHMM2.0 at aa 7-29, 44-66, 79-101, 116-133, 146-168 and 183-205 637910024857 HMMPfam hit to PF02517, Abortive infection protein, score 7.4e-26 637910024858 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 637910024859 HMMPfam hit to PF04014, SpoVT/AbrB-like, predicted transcription regulator, score 2.4e-05 637910024860 PemK-like protein; Region: PemK; cl00995 637910024861 HMMPfam hit to PF02452, PemK-like protein, score 1.9e-53 637910024862 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 637910024863 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 637910024864 hypothetical protein; Provisional; Region: PRK09945 637910024865 hypothetical protein; Provisional; Region: PRK09945 637910024866 hypothetical protein; Provisional; Region: PRK09945 637910024867 hypothetical protein; Provisional; Region: PRK09945 637910024868 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 637910024869 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637910024870 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637910024871 1 probable transmembrane helix predicted for ROD_p1121 by TMHMM2.0 at aa 33-55 637910024872 HMMPfam hit to PF02415, Polymorphic membrane protein, Chlamydia, score 18 637910024873 HMMPfam hit to PF03212, Pertactin, score 1.1e-59 637910024874 HMMPfam hit to PF03797, Autotransporter beta-domain, score 1.2e-38 637910024875 HMMPfam hit to PF02415, Polymorphic membrane protein, Chlamydia, score 23 637910024876 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 637910024877 DNA binding residues [nucleotide binding] 637910024878 pseudogene, C-terminus missing, N-terminal region truncated by frameshift mutation 637910024879 Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012 637910024880 HMMPfam hit to PF03333, P pili regulatory PapB protein, score 6.8e-08 637910024881 fimbrial protein PefA; Provisional; Region: PRK15214 637910024882 HMMPfam hit to PF00419, Fimbrial protein, C-terminal, score 0.00072 637910024883 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 637910024884 PapC N-terminal domain; Region: PapC_N; pfam13954 637910024885 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637910024886 PapC C-terminal domain; Region: PapC_C; pfam13953 637910024887 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 1.5e-270 637910024888 PS00017 ATP/GTP-binding site motif A (P-loop). 637910024889 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 637910024890 fimbrial chaperone protein PefD; Provisional; Region: PRK15211 637910024891 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 637910024892 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 637910024893 1 probable transmembrane helix predicted for ROD_p1191 by TMHMM2.0 at aa 7-29 637910024894 HMMPfam hit to PF00345, Bacterial pili assembly chaperone, score 5.9e-48 637910024895 PS00635 Gram-negative pili assembly chaperone signature. 637910024896 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 2.7e-16 637910024897 1 probable transmembrane helix predicted for ROD_p1201 by TMHMM2.0 at aa 7-25 637910024898 1 probable transmembrane helix predicted for ROD_p1211 by TMHMM2.0 at aa 50-72 637910024899 1 probable transmembrane helix predicted for ROD_p1221 by TMHMM2.0 at aa 38-60 637910024900 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 637910024901 1 probable transmembrane helix predicted for ROD_p1231 by TMHMM2.0 at aa 12-34 637910024902 HMMPfam hit to PF00563, EAL, score 3.6e-38 637910024903 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 637910024904 catalytic core [active] 637910024905 1 probable transmembrane helix predicted for ROD_p1241 by TMHMM2.0 at aa 15-33 637910024906 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 0.00041 637910024907 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 637910024908 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 637910024909 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 637910024910 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637910024911 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637910024912 HMMPfam hit to PF03797, Autotransporter beta-domain, score 3e-43 637910024913 HMMPfam hit to PF02395, Peptidase S6, IgA endopeptidase, score 4.4e-178 637910024914 1 probable transmembrane helix predicted for ROD_p1251 by TMHMM2.0 at aa 34-53 637910024915 pseudogene, N-terminus missing, C-terminal region truncated by frameshift mutation 637910024916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 637910024917 non-specific DNA binding site [nucleotide binding]; other site 637910024918 salt bridge; other site 637910024919 sequence-specific DNA binding site [nucleotide binding]; other site 637910024920 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 5.3e-06 637910024921 Predicted helix-turn-helix motif with score 1179.000, SD 3.20 at aa 49-70, sequence MKQAEFAEVVGASVDLIRSWEQ 637910024922 pseudogene, N-terminus missing, fragment 637910024923 HMMPfam hit to PF02753, Bacterial pili assembly chaperone, score 3.9e-21 637910024924 PapC N-terminal domain; Region: PapC_N; pfam13954 637910024925 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 637910024926 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 637910024927 PapC C-terminal domain; Region: PapC_C; pfam13953 637910024928 HMMPfam hit to PF00577, Fimbrial biogenesis outer membrane usher protein, score 0 637910024929 1 probable transmembrane helix predicted for ROD_p1311 by TMHMM2.0 at aa 10-32 637910024930 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 637910024931 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 637910024932 oligomeric interface; other site 637910024933 putative active site [active] 637910024934 homodimer interface [polypeptide binding]; other site 637910024935 HMMPfam hit to PF01850, PilT protein, N-terminal, score 7.3e-20 637910024936 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 637910024937 HMMPfam hit to PF04014, SpoVT/AbrB-like, predicted transcription regulator, score 0.00013 637910024938 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 637910024939 HMMPfam hit to PF07362, Post-segregation antitoxin CcdA, score 8e-49 637910024940 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 637910024941 HMMPfam hit to PF01845, CcdB protein, score 2.6e-76 637910024942 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 637910024943 active site 637910024944 catalytic residues [active] 637910024945 DNA binding site [nucleotide binding] 637910024946 Int/Topo IB signature motif; other site 637910024947 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 1.3e-49 637910024948 Predicted helix-turn-helix motif with score 1208.000, SD 3.30 at aa 156-177, sequence TGRTEKTRIWEITDRTVRTWIN 637910024949 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 637910024950 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 637910024951 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 637910024952 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 637910024953 Autotransporter beta-domain; Region: Autotransporter; pfam03797 637910024954 HMMPfam hit to PF03797, Autotransporter beta-domain, score 9.2e-44 637910024955 HMMPfam hit to PF02395, Peptidase S6, IgA endopeptidase, score 0 637910024956 1 probable transmembrane helix predicted for ROD_p1411 by TMHMM2.0 at aa 36-58 637910024957 Lysis protein; Region: Lysis_col; pfam02402 637910024958 HMMPfam hit to PF02402, Colicin lysis protein, score 3.2e-15 637910024959 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910024960 Colicin immunity protein; Region: Colicin_im; pfam03857 637910024961 4 probable transmembrane helices predicted for ROD_p1431 by TMHMM2.0 at aa 17-39, 69-88, 101-123 and 143-165 637910024962 HMMPfam hit to PF03857, Colicin immunity protein, score 6.9e-87 637910024963 Colicin pore forming domain; Region: Colicin; pfam01024 637910024964 HMMPfam hit to PF01024, Channel forming colicin, C-terminal cytotoxic, score 1.3e-99 637910024965 2 probable transmembrane helices predicted for ROD_p1441 by TMHMM2.0 at aa 453-475 and 477-499 637910024966 PS00276 Channel forming colicins signature. 637910024967 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 637910024968 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 637910024969 catalytic residues [active] 637910024970 catalytic nucleophile [active] 637910024971 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 637910024972 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 6.3e-06 637910024973 Predicted helix-turn-helix motif with score 1780.000, SD 5.25 at aa 181-202, sequence KSLRETARLAGVSKMTVIRVCN 637910024974 HMMPfam hit to PF00239, Resolvase, N-terminal, score 9.1e-41 637910024975 PS00398 Site-specific recombinases signature 2. 637910024976 PS00397 Site-specific recombinases active site. 637910024977 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 637910024978 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 2.1e-09 637910024979 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 637910024980 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 637910024981 P-loop; other site 637910024982 Magnesium ion binding site [ion binding]; other site 637910024983 pseudogene, N-terminus deleted by ISCro1 insertion, C-terminal region truncated by frameshift mutation 637910024984 HMMPfam hit to PF01051, Initiator RepB protein, score 5.4e-24 637910024985 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 637910024986 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 637910024987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910024988 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 637910024989 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 637910024990 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 637910024991 HMMPfam hit to PF03050, Transposase, IS66, score 4.4e-129 637910024992 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 637910024993 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 637910024994 HMMPfam hit to PF05717, Transposase (putative), IS66 Orf2 like, score 5.7e-70 637910024995 Transposase; Region: HTH_Tnp_1; pfam01527 637910024996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 637910024997 HMMPfam hit to PF01527, Transposase IS3/IS911, score 2e-22 637910024998 Predicted helix-turn-helix motif with score 1051.000, SD 2.77 at aa 29-50, sequence LPRVVAGRRLGVPKSTVCSMFV 637910024999 pseudogene, N-terminus deleted by ISCro1 insertion 637910025000 HMMPfam hit to PF00565, Staphylococcus nuclease (SNase-like), score 1.2e-59 637910025001 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 637910025002 1 probable transmembrane helix predicted for ROD_p1591 by TMHMM2.0 at aa 3-22 637910025003 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 637910025004 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 637910025005 HicB family; Region: HicB; pfam05534 637910025006 HMMPfam hit to PF05534, HicB, score 4.7e-24 637910025007 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 637910025008 Predicted helix-turn-helix motif with score 1292.000, SD 3.59 at aa 19-40, sequence LTQKECSHIYGVGLRTWQKKEE 637910025009 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 637910025010 HSP70 interaction site [polypeptide binding]; other site 637910025011 HMMPfam hit to PF00226, Heat shock protein DnaJ, N-terminal, score 5.7e-16 637910025012 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 637910025013 Predicted helix-turn-helix motif with score 1642.000, SD 4.78 at aa 67-88, sequence GGISEAARKSGLARQSIYRALS 637910025014 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 637910025015 HMMPfam hit to PF05016, Plasmid stabilization system, score 4.7e-16 637910025016 primosomal protein DnaI; Provisional; Region: PRK02854 637910025017 RelB antitoxin; Region: RelB; cl01171 637910025018 HMMPfam hit to PF02604, Protein of unknown function DUF172, score 2e-13 637910025019 Initiator Replication protein; Region: Rep_3; pfam01051 637910025020 HMMPfam hit to PF01051, Initiator RepB protein, score 2.6e-56 637910025021 3 probable transmembrane helices predicted for ROD_p2151 by TMHMM2.0 at aa 37-59, 64-86 and 91-113 637910025022 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910025023 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 637910025024 2 probable transmembrane helices predicted for ROD_p2171 by TMHMM2.0 at aa 20-37 and 41-60 637910025025 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910025026 2 probable transmembrane helices predicted for ROD_p2181 by TMHMM2.0 at aa 15-37 and 44-66 637910025027 2 probable transmembrane helices predicted for ROD_p2191 by TMHMM2.0 at aa 9-31 and 41-60 637910025028 ParA-like protein; Provisional; Region: PHA02518 637910025029 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 637910025030 P-loop; other site 637910025031 Magnesium ion binding site [ion binding]; other site 637910025032 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 637910025033 active site 637910025034 catalytic residues [active] 637910025035 DNA binding site [nucleotide binding] 637910025036 Int/Topo IB signature motif; other site 637910025037 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 2.8e-20 637910025038 1 probable transmembrane helix predicted for ROD_p2241 by TMHMM2.0 at aa 13-30 637910025039 PS00017 ATP/GTP-binding site motif A (P-loop). 637910025040 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910025041 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 637910025042 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 637910025043 HMMPfam hit to PF00816, Histone-like nucleoid-structuring protein H-NS, score 6.7e-17 637910025044 Haemolysin expression modulating protein; Region: HHA; pfam05321 637910025045 HMMPfam hit to PF05321, Haemolysin expression modulating, score 7.1e-34 637910025046 DNA topoisomerase III; Provisional; Region: PRK07726 637910025047 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 637910025048 active site 637910025049 putative interdomain interaction site [polypeptide binding]; other site 637910025050 putative metal-binding site [ion binding]; other site 637910025051 putative nucleotide binding site [chemical binding]; other site 637910025052 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 637910025053 domain I; other site 637910025054 DNA binding groove [nucleotide binding] 637910025055 phosphate binding site [ion binding]; other site 637910025056 domain II; other site 637910025057 domain III; other site 637910025058 nucleotide binding site [chemical binding]; other site 637910025059 catalytic site [active] 637910025060 domain IV; other site 637910025061 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 637910025062 HMMPfam hit to PF01396, DNA topoisomerase, type IA, zn finger, score 0.0092 637910025063 HMMPfam hit to PF01131, DNA topoisomerase, type IA, central, score 3.4e-99 637910025064 HMMPfam hit to PF01751, TOPRIM, score 5.7e-12 637910025065 Staphylococcal nuclease homologues; Region: SNc; smart00318 637910025066 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 637910025067 Catalytic site; other site 637910025068 HMMPfam hit to PF00565, Staphylococcus nuclease (SNase-like), score 1.3e-47 637910025069 PS01123 Thermonuclease family signature 1. 637910025070 2 probable transmembrane helices predicted for ROD_p2341 by TMHMM2.0 at aa 16-38 and 108-130 637910025071 YadA-like C-terminal region; Region: YadA; pfam03895 637910025072 HMMPfam hit to PF02524, RepA / Rep+ protein KID, score 4.8 637910025073 Conjugative plasmid transfer locus. Similar to region on Y. Enteriticola p29930 except Y. Ent is missing taxB and taxC. also similar to E. coli IncX plasmid R6K region. eex is found in a different location from these plasmids. 637910025074 TrbM; Region: TrbM; pfam07424 637910025075 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 637910025076 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910025077 type IV secretion system component VirD4; Provisional; Region: PRK13897 637910025078 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 637910025079 Walker A motif; other site 637910025080 ATP binding site [chemical binding]; other site 637910025081 Walker B motif; other site 637910025082 HMMPfam hit to PF02534, TRAG protein, score 2.6e-92 637910025083 2 probable transmembrane helices predicted for ROD_p2391 by TMHMM2.0 at aa 10-32 and 72-94 637910025084 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 637910025085 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 637910025086 Walker A motif; other site 637910025087 hexamer interface [polypeptide binding]; other site 637910025088 ATP binding site [chemical binding]; other site 637910025089 Walker B motif; other site 637910025090 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 1.1e-56 637910025091 PS00017 ATP/GTP-binding site motif A (P-loop). 637910025092 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 637910025093 HMMPfam hit to PF03743, Bacterial conjugation TrbI-like protein, score 5.7e-80 637910025094 1 probable transmembrane helix predicted for ROD_p2411 by TMHMM2.0 at aa 39-56 637910025095 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 637910025096 VirB7 interaction site; other site 637910025097 HMMPfam hit to PF03524, Conjugal transfer protein TrbG/VirB9/CagX, score 3.8e-26 637910025098 1 probable transmembrane helix predicted for ROD_p2421 by TMHMM2.0 at aa 5-27 637910025099 VirB8 protein; Region: VirB8; pfam04335 637910025100 HMMPfam hit to PF04335, VirB8, score 1.8e-48 637910025101 1 probable transmembrane helix predicted for ROD_p2431 by TMHMM2.0 at aa 30-52 637910025102 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 637910025103 PS00017 ATP/GTP-binding site motif A (P-loop). 637910025104 HMMPfam hit to PF04610, TrbL/VirB6 plasmid conjugal transfer protein, score 1.3e-55 637910025105 4 probable transmembrane helices predicted for ROD_p2451 by TMHMM2.0 at aa 127-149, 159-180, 187-209 and 229-248 637910025106 pseudogene, disrupted by IS102 insertion, putative conjugal transfer protein TriD (pseudogene) 637910025107 HMMPfam hit to PF07996, Type IV secretion system, score 0.00035 637910025108 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 637910025109 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 637910025110 HMMPfam hit to PF01609, Transposase, IS4-like, score 9.3e-30 637910025111 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 637910025112 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 637910025113 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 637910025114 PS00017 ATP/GTP-binding site motif A (P-loop). 637910025115 HMMPfam hit to PF03135, CagE, TrbE, VirB component of type IV transporter system, score 4e-54 637910025116 HMMPfam hit to PF05101, Type IV secretory pathway, VirB3-like, score 9.1e-19 637910025117 1 probable transmembrane helix predicted for ROD_p2481 by TMHMM2.0 at aa 13-35 637910025118 TrbC/VIRB2 family; Region: TrbC; pfam04956 637910025119 3 probable transmembrane helices predicted for ROD_p2491 by TMHMM2.0 at aa 19-38, 53-75 and 82-101 637910025120 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910025121 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 637910025122 N-acetyl-D-glucosamine binding site [chemical binding]; other site 637910025123 catalytic residue [active] 637910025124 HMMPfam hit to PF01464, Lytic transglycosylase-like, catalytic, score 1.6e-05 637910025125 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 637910025126 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 637910025127 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 637910025128 DNA binding residues [nucleotide binding] 637910025129 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 637910025130 HMMPfam hit to PF03432, Endonuclease relaxase, MobA/VirD2, score 0.00069 637910025131 MobA/MobL family; Region: MobA_MobL; pfam03389 637910025132 HMMPfam hit to PF03389, MobA/MobL protein, score 2.2e-73 637910025133 Replicase family; Region: Replicase; pfam03090 637910025134 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 637910025135 Homeodomain-like domain; Region: HTH_23; pfam13384 637910025136 HMMPfam hit to PF03090, Bacterial plasmid replicase, score 1e-77 637910025137 HMMPfam hit to PF08708, Primase, C-terminal 1, score 3.8e-29 637910025138 Predicted helix-turn-helix motif with score 1525.000, SD 4.38 at aa 304-325, sequence ASTEDIAVAVGVSSRTIRRWMD 637910025139 Conjugal transfer protein TraD; Region: TraD; pfam06412