-- dump date   	20140619_042208
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1097677000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1097677000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097677000003	Walker A motif; other site
1097677000004	ATP binding site [chemical binding]; other site
1097677000005	Walker B motif; other site
1097677000006	arginine finger; other site
1097677000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1097677000008	DnaA box-binding interface [nucleotide binding]; other site
1097677000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
1097677000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1097677000011	putative DNA binding surface [nucleotide binding]; other site
1097677000012	dimer interface [polypeptide binding]; other site
1097677000013	beta-clamp/clamp loader binding surface; other site
1097677000014	beta-clamp/translesion DNA polymerase binding surface; other site
1097677000015	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1097677000016	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
1097677000017	recombination protein F; Reviewed; Region: recF; PRK00064
1097677000018	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1097677000019	Walker A/P-loop; other site
1097677000020	ATP binding site [chemical binding]; other site
1097677000021	Q-loop/lid; other site
1097677000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677000023	ABC transporter signature motif; other site
1097677000024	Walker B; other site
1097677000025	D-loop; other site
1097677000026	H-loop/switch region; other site
1097677000027	Protein of unknown function (DUF721); Region: DUF721; cl02324
1097677000028	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1097677000029	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1097677000030	anchoring element; other site
1097677000031	dimer interface [polypeptide binding]; other site
1097677000032	ATP binding site [chemical binding]; other site
1097677000033	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1097677000034	active site
1097677000035	putative metal-binding site [ion binding]; other site
1097677000036	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1097677000037	DNA gyrase subunit A; Validated; Region: PRK05560
1097677000038	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1097677000039	CAP-like domain; other site
1097677000040	active site
1097677000041	primary dimer interface [polypeptide binding]; other site
1097677000042	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1097677000043	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1097677000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1097677000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1097677000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1097677000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1097677000048	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
1097677000049	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1097677000050	active site
1097677000051	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1097677000052	Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781
1097677000053	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
1097677000054	active site
1097677000055	catalytic site [active]
1097677000056	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1097677000057	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1097677000058	glutamine binding [chemical binding]; other site
1097677000059	catalytic triad [active]
1097677000060	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1097677000061	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1097677000062	active site
1097677000063	ATP binding site [chemical binding]; other site
1097677000064	substrate binding site [chemical binding]; other site
1097677000065	activation loop (A-loop); other site
1097677000066	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1097677000067	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1097677000068	PASTA domain; Region: PASTA; pfam03793
1097677000069	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1097677000070	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1097677000071	active site
1097677000072	ATP binding site [chemical binding]; other site
1097677000073	substrate binding site [chemical binding]; other site
1097677000074	activation loop (A-loop); other site
1097677000075	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1097677000076	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1097677000077	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1097677000078	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1097677000079	active site
1097677000080	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1097677000081	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1097677000082	phosphopeptide binding site; other site
1097677000083	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
1097677000084	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1097677000085	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1097677000086	phosphopeptide binding site; other site
1097677000087	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1097677000088	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097677000089	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677000090	active site
1097677000091	phosphorylation site [posttranslational modification]
1097677000092	intermolecular recognition site; other site
1097677000093	dimerization interface [polypeptide binding]; other site
1097677000094	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097677000095	DNA binding residues [nucleotide binding]
1097677000096	dimerization interface [polypeptide binding]; other site
1097677000097	Histidine kinase; Region: HisKA_3; pfam07730
1097677000098	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1097677000099	ATP binding site [chemical binding]; other site
1097677000100	Mg2+ binding site [ion binding]; other site
1097677000101	G-X-G motif; other site
1097677000102	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
1097677000103	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1097677000104	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1097677000105	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097677000106	ATP binding site [chemical binding]; other site
1097677000107	putative Mg++ binding site [ion binding]; other site
1097677000108	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097677000109	nucleotide binding region [chemical binding]; other site
1097677000110	ATP-binding site [chemical binding]; other site
1097677000111	Protein of unknown function (DUF3553); Region: DUF3553; pfam12073
1097677000112	hypothetical protein; Provisional; Region: PRK07236
1097677000113	hypothetical protein; Validated; Region: PRK05868
1097677000114	hypothetical protein; Provisional; Region: PRK07236
1097677000115	MarR family; Region: MarR_2; pfam12802
1097677000116	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097677000117	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1097677000118	Glutaminase; Region: Glutaminase; cl00907
1097677000119	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097677000120	TAP-like protein; Region: Abhydrolase_4; pfam08386
1097677000121	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1097677000122	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097677000123	active site
1097677000124	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1097677000125	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097677000126	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097677000127	HEAT repeats; Region: HEAT_2; pfam13646
1097677000128	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1097677000129	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097677000130	non-specific DNA binding site [nucleotide binding]; other site
1097677000131	salt bridge; other site
1097677000132	sequence-specific DNA binding site [nucleotide binding]; other site
1097677000133	Domain of unknown function (DUF955); Region: DUF955; cl01076
1097677000134	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
1097677000135	Dienelactone hydrolase family; Region: DLH; pfam01738
1097677000136	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677000137	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1097677000138	putative substrate translocation pore; other site
1097677000139	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1097677000141	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1097677000142	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097677000143	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097677000144	acyl-activating enzyme (AAE) consensus motif; other site
1097677000145	acyl-activating enzyme (AAE) consensus motif; other site
1097677000146	AMP binding site [chemical binding]; other site
1097677000147	active site
1097677000148	CoA binding site [chemical binding]; other site
1097677000149	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1097677000150	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
1097677000151	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677000152	NAD(P) binding site [chemical binding]; other site
1097677000153	active site
1097677000154	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
1097677000155	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097677000156	classical (c) SDRs; Region: SDR_c; cd05233
1097677000157	NAD(P) binding site [chemical binding]; other site
1097677000158	active site
1097677000159	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1097677000160	putative substrate binding pocket [chemical binding]; other site
1097677000161	AC domain interface; other site
1097677000162	catalytic triad [active]
1097677000163	AB domain interface; other site
1097677000164	interchain disulfide; other site
1097677000165	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
1097677000166	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677000167	Phosphotransferase enzyme family; Region: APH; pfam01636
1097677000168	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1097677000169	active site
1097677000170	ATP binding site [chemical binding]; other site
1097677000171	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1097677000172	substrate binding site [chemical binding]; other site
1097677000173	MarR family; Region: MarR_2; cl17246
1097677000174	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1097677000175	Catalytic site [active]
1097677000176	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1097677000177	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1097677000178	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1097677000179	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1097677000180	Catalytic site [active]
1097677000181	legume lectins; Region: lectin_L-type; cl14058
1097677000182	homodimer interaction site [polypeptide binding]; other site
1097677000183	carbohydrate binding site [chemical binding]; other site
1097677000184	metal binding site [ion binding]; metal-binding site
1097677000185	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1097677000186	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1097677000187	nucleotide binding site [chemical binding]; other site
1097677000188	GrpE; Region: GrpE; pfam01025
1097677000189	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1097677000190	dimer interface [polypeptide binding]; other site
1097677000191	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1097677000192	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1097677000193	HSP70 interaction site [polypeptide binding]; other site
1097677000194	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1097677000195	dimer interface [polypeptide binding]; other site
1097677000196	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
1097677000197	DNA binding residues [nucleotide binding]
1097677000198	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1097677000199	putative dimer interface [polypeptide binding]; other site
1097677000200	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
1097677000201	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097677000202	S-adenosylmethionine binding site [chemical binding]; other site
1097677000203	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
1097677000204	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1097677000205	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097677000206	non-specific DNA binding site [nucleotide binding]; other site
1097677000207	salt bridge; other site
1097677000208	sequence-specific DNA binding site [nucleotide binding]; other site
1097677000209	Sensors of blue-light using FAD; Region: BLUF; pfam04940
1097677000210	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
1097677000211	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097677000212	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097677000213	DNA binding site [nucleotide binding]
1097677000214	domain linker motif; other site
1097677000215	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1097677000216	dimerization interface [polypeptide binding]; other site
1097677000217	ligand binding site [chemical binding]; other site
1097677000218	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1097677000219	Glyco_18 domain; Region: Glyco_18; smart00636
1097677000220	active site
1097677000221	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097677000222	active site
1097677000223	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1097677000224	active site
1097677000225	oxyanion hole [active]
1097677000226	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1097677000227	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1097677000228	Walker A/P-loop; other site
1097677000229	ATP binding site [chemical binding]; other site
1097677000230	Q-loop/lid; other site
1097677000231	ABC transporter signature motif; other site
1097677000232	Walker B; other site
1097677000233	D-loop; other site
1097677000234	H-loop/switch region; other site
1097677000235	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1097677000236	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1097677000237	siderophore binding site; other site
1097677000238	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1097677000239	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1097677000240	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1097677000241	ABC-ATPase subunit  interface; other site
1097677000242	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1097677000243	dimer interface [polypeptide binding]; other site
1097677000244	putative PBP binding regions; other site
1097677000245	ABC-ATPase subunit  interface; other site
1097677000246	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
1097677000247	ligand binding site [chemical binding]; other site
1097677000248	putative phosphoketolase; Provisional; Region: PRK05261
1097677000249	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
1097677000250	TPP-binding site; other site
1097677000251	XFP C-terminal domain; Region: XFP_C; pfam09363
1097677000252	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1097677000253	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1097677000254	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1097677000255	propionate/acetate kinase; Provisional; Region: PRK12379
1097677000256	Domain of unknown function (DUF955); Region: DUF955; cl01076
1097677000257	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
1097677000258	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097677000259	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677000260	active site
1097677000261	phosphorylation site [posttranslational modification]
1097677000262	intermolecular recognition site; other site
1097677000263	dimerization interface [polypeptide binding]; other site
1097677000264	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097677000265	DNA binding residues [nucleotide binding]
1097677000266	dimerization interface [polypeptide binding]; other site
1097677000267	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1097677000268	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1097677000269	Histidine kinase; Region: HisKA_3; pfam07730
1097677000270	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1097677000271	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097677000272	Ligand Binding Site [chemical binding]; other site
1097677000273	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
1097677000274	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
1097677000275	NAD(P) binding site [chemical binding]; other site
1097677000276	LDH/MDH dimer interface [polypeptide binding]; other site
1097677000277	substrate binding site [chemical binding]; other site
1097677000278	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1097677000279	L-lactate permease; Region: Lactate_perm; cl00701
1097677000280	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097677000281	Ligand Binding Site [chemical binding]; other site
1097677000282	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097677000283	Ligand Binding Site [chemical binding]; other site
1097677000284	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1097677000285	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097677000286	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1097677000287	Coenzyme A binding pocket [chemical binding]; other site
1097677000288	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1097677000289	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097677000290	Coenzyme A binding pocket [chemical binding]; other site
1097677000291	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1097677000292	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097677000293	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1097677000294	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1097677000295	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1097677000296	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1097677000297	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1097677000298	Fic/DOC family; Region: Fic; cl00960
1097677000299	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
1097677000300	FIC domain binding interface [polypeptide binding]; other site
1097677000301	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1097677000302	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1097677000303	NAD(P) binding site [chemical binding]; other site
1097677000304	catalytic residues [active]
1097677000305	Cms ortholog CMS_0350; missing in Cmm
1097677000306	Cmm ortholog CMM_0184; Cms ortholog CMS_0352
1097677000307	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1097677000308	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677000309	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1097677000310	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677000311	putative substrate translocation pore; other site
1097677000312	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097677000313	non-specific DNA binding site [nucleotide binding]; other site
1097677000314	salt bridge; other site
1097677000315	sequence-specific DNA binding site [nucleotide binding]; other site
1097677000316	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097677000317	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677000318	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097677000319	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097677000320	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1097677000321	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677000322	dimer interface [polypeptide binding]; other site
1097677000323	ABC-ATPase subunit interface; other site
1097677000324	putative PBP binding loops; other site
1097677000325	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097677000326	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677000327	dimer interface [polypeptide binding]; other site
1097677000328	conserved gate region; other site
1097677000329	putative PBP binding loops; other site
1097677000330	ABC-ATPase subunit interface; other site
1097677000331	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1097677000332	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1097677000333	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1097677000334	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097677000335	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097677000336	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1097677000337	MMPL family; Region: MMPL; pfam03176
1097677000338	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097677000339	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677000340	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
1097677000341	dimerization interface [polypeptide binding]; other site
1097677000342	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1097677000343	NAD binding site [chemical binding]; other site
1097677000344	ligand binding site [chemical binding]; other site
1097677000345	catalytic site [active]
1097677000346	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
1097677000347	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
1097677000348	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097677000349	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097677000350	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
1097677000351	putative dimerization interface [polypeptide binding]; other site
1097677000352	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1097677000353	Cmm ortholog CMM_0206; missing in Cms
1097677000354	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1097677000355	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1097677000356	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1097677000357	active site
1097677000358	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1097677000359	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1097677000360	active site
1097677000361	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1097677000362	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1097677000363	catalytic residues [active]
1097677000364	catalytic nucleophile [active]
1097677000365	Presynaptic Site I dimer interface [polypeptide binding]; other site
1097677000366	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1097677000367	Synaptic Flat tetramer interface [polypeptide binding]; other site
1097677000368	Synaptic Site I dimer interface [polypeptide binding]; other site
1097677000369	DNA binding site [nucleotide binding]
1097677000370	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1097677000371	DNA-binding interface [nucleotide binding]; DNA binding site
1097677000372	CBD_II domain; Region: CBD_II; smart00637
1097677000373	Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305
1097677000374	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1097677000375	hypothetical protein; Provisional; Region: PRK09256
1097677000376	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1097677000377	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1097677000378	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
1097677000379	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
1097677000380	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1097677000381	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677000382	no orthologs in Cmm and Cms
1097677000383	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
1097677000384	FIC domain binding interface [polypeptide binding]; other site
1097677000385	enoyl_reductase_like; Region: enoyl_reductase_like; cd08249
1097677000386	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1097677000387	NAD(P) binding site [chemical binding]; other site
1097677000388	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
1097677000389	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1097677000390	active site residue [active]
1097677000391	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1097677000392	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1097677000393	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1097677000394	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1097677000395	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1097677000396	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097677000397	motif II; other site
1097677000398	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1097677000399	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
1097677000400	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1097677000401	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1097677000402	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
1097677000403	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097677000404	short chain dehydrogenase; Provisional; Region: PRK06523
1097677000405	classical (c) SDRs; Region: SDR_c; cd05233
1097677000406	NAD(P) binding site [chemical binding]; other site
1097677000407	active site
1097677000408	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097677000409	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677000410	TetR family transcriptional regulator; Provisional; Region: PRK14996
1097677000411	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677000412	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1097677000413	Predicted acyl esterases [General function prediction only]; Region: COG2936
1097677000414	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097677000415	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
1097677000416	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1097677000417	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097677000418	Walker A/P-loop; other site
1097677000419	ATP binding site [chemical binding]; other site
1097677000420	Q-loop/lid; other site
1097677000421	ABC transporter signature motif; other site
1097677000422	Walker B; other site
1097677000423	D-loop; other site
1097677000424	H-loop/switch region; other site
1097677000425	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097677000426	Walker A/P-loop; other site
1097677000427	ATP binding site [chemical binding]; other site
1097677000428	Q-loop/lid; other site
1097677000429	ABC transporter signature motif; other site
1097677000430	Walker B; other site
1097677000431	D-loop; other site
1097677000432	H-loop/switch region; other site
1097677000433	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1097677000434	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1097677000435	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677000436	dimer interface [polypeptide binding]; other site
1097677000437	conserved gate region; other site
1097677000438	putative PBP binding loops; other site
1097677000439	ABC-ATPase subunit interface; other site
1097677000440	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1097677000441	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677000442	ABC-ATPase subunit interface; other site
1097677000443	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
1097677000444	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1097677000445	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1097677000446	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1097677000447	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677000448	NAD(P) binding site [chemical binding]; other site
1097677000449	active site
1097677000450	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
1097677000451	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677000452	Beta protein; Region: Beta_protein; pfam14350
1097677000453	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
1097677000454	short chain dehydrogenase; Provisional; Region: PRK06180
1097677000455	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1097677000456	NADP binding site [chemical binding]; other site
1097677000457	active site
1097677000458	steroid binding site; other site
1097677000459	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
1097677000460	active site
1097677000461	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1097677000462	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1097677000463	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1097677000464	DNA binding site [nucleotide binding]
1097677000465	active site
1097677000466	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1097677000467	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097677000468	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097677000469	DNA binding residues [nucleotide binding]
1097677000470	Response regulator receiver domain; Region: Response_reg; pfam00072
1097677000471	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677000472	active site
1097677000473	phosphorylation site [posttranslational modification]
1097677000474	intermolecular recognition site; other site
1097677000475	dimerization interface [polypeptide binding]; other site
1097677000476	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1097677000477	Cmm ortholog CMM_0245; Cms ortholog CMS_0821
1097677000478	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097677000479	dimerization interface [polypeptide binding]; other site
1097677000480	putative Zn2+ binding site [ion binding]; other site
1097677000481	putative DNA binding site [nucleotide binding]; other site
1097677000482	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1097677000483	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
1097677000484	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1097677000485	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1097677000486	putative NAD(P) binding site [chemical binding]; other site
1097677000487	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097677000488	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1097677000489	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097677000490	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097677000491	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1097677000492	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1097677000493	active site
1097677000494	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
1097677000495	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1097677000496	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1097677000497	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097677000498	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097677000499	DNA binding site [nucleotide binding]
1097677000500	domain linker motif; other site
1097677000501	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1097677000502	dimerization interface [polypeptide binding]; other site
1097677000503	ligand binding site [chemical binding]; other site
1097677000504	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1097677000505	hypothetical protein; Validated; Region: PRK06201
1097677000506	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
1097677000507	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097677000508	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1097677000509	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097677000510	no orthologs in Cmm and Cms
1097677000511	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1097677000512	putative active site [active]
1097677000513	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
1097677000514	CrcB-like protein; Region: CRCB; pfam02537
1097677000515	CrcB-like protein; Region: CRCB; cl09114
1097677000516	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1097677000517	ADP-ribose binding site [chemical binding]; other site
1097677000518	dimer interface [polypeptide binding]; other site
1097677000519	active site
1097677000520	nudix motif; other site
1097677000521	metal binding site [ion binding]; metal-binding site
1097677000522	Predicted membrane protein [Function unknown]; Region: COG4270
1097677000523	RibD C-terminal domain; Region: RibD_C; cl17279
1097677000524	Protein of unknown function (DUF3100); Region: DUF3100; pfam11299
1097677000525	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1097677000526	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1097677000527	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1097677000528	putative active site [active]
1097677000529	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1097677000530	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1097677000531	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097677000532	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1097677000533	NAD(P) binding site [chemical binding]; other site
1097677000534	catalytic residues [active]
1097677000535	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1097677000536	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1097677000537	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677000538	dimer interface [polypeptide binding]; other site
1097677000539	conserved gate region; other site
1097677000540	putative PBP binding loops; other site
1097677000541	ABC-ATPase subunit interface; other site
1097677000542	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097677000543	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677000544	dimer interface [polypeptide binding]; other site
1097677000545	conserved gate region; other site
1097677000546	putative PBP binding loops; other site
1097677000547	ABC-ATPase subunit interface; other site
1097677000548	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1097677000549	conserved cys residue [active]
1097677000550	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097677000551	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097677000552	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1097677000553	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1097677000554	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1097677000555	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097677000556	motif II; other site
1097677000557	Chorismate mutase type II; Region: CM_2; cl00693
1097677000558	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
1097677000559	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677000560	AAA domain; Region: AAA_21; pfam13304
1097677000561	Walker A/P-loop; other site
1097677000562	ATP binding site [chemical binding]; other site
1097677000563	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1097677000564	Cmm ortholog CMM_0248; no Cms ortholog
1097677000565	AAA domain; Region: AAA_17; pfam13207
1097677000566	Cmm ortholog CMM_0284; Cms ortholog CMS_0850
1097677000567	Cmm ortholog CMM_0286; Cms ortholog Cms_0852
1097677000568	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1097677000569	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097677000570	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677000571	NAD(P) binding site [chemical binding]; other site
1097677000572	active site
1097677000573	YceI-like domain; Region: YceI; pfam04264
1097677000574	no orthologs in Cmm and Cms
1097677000575	Pectinesterase; Region: Pectinesterase; pfam01095
1097677000576	putative pectinesterase; Region: PLN02432; cl01911
1097677000577	putative pectinesterase; Region: PLN02432; cl01911
1097677000578	Pectinesterase; Region: Pectinesterase; pfam01095
1097677000579	putative pectinesterase; Region: PLN02432; cl01911
1097677000580	putative pectinesterase; Region: PLN02432; cl01911
1097677000581	putative pectinesterase; Region: PLN02432; cl01911
1097677000582	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
1097677000583	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097677000584	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1097677000585	DNA binding residues [nucleotide binding]
1097677000586	Putative zinc-finger; Region: zf-HC2; pfam13490
1097677000587	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1097677000588	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097677000589	non-specific DNA binding site [nucleotide binding]; other site
1097677000590	salt bridge; other site
1097677000591	sequence-specific DNA binding site [nucleotide binding]; other site
1097677000592	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1097677000593	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677000594	H+ Antiporter protein; Region: 2A0121; TIGR00900
1097677000595	putative substrate translocation pore; other site
1097677000596	Tetratrico peptide repeat; Region: TPR_5; pfam12688
1097677000597	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097677000598	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097677000599	DNA binding site [nucleotide binding]
1097677000600	domain linker motif; other site
1097677000601	Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296
1097677000602	putative dimerization interface [polypeptide binding]; other site
1097677000603	putative ligand binding site [chemical binding]; other site
1097677000604	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1097677000605	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1097677000606	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097677000607	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677000608	dimer interface [polypeptide binding]; other site
1097677000609	conserved gate region; other site
1097677000610	putative PBP binding loops; other site
1097677000611	ABC-ATPase subunit interface; other site
1097677000612	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097677000613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677000614	dimer interface [polypeptide binding]; other site
1097677000615	conserved gate region; other site
1097677000616	putative PBP binding loops; other site
1097677000617	ABC-ATPase subunit interface; other site
1097677000618	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
1097677000619	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1097677000620	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1097677000622	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1097677000623	OHCU decarboxylase; Region: UraD_2; TIGR03180
1097677000624	urate oxidase; Region: urate_oxi; TIGR03383
1097677000625	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1097677000626	active site
1097677000627	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1097677000628	active site
1097677000629	homotetramer interface [polypeptide binding]; other site
1097677000630	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1097677000631	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1097677000632	allantoate amidohydrolase; Reviewed; Region: PRK09290
1097677000633	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1097677000634	active site
1097677000635	metal binding site [ion binding]; metal-binding site
1097677000636	dimer interface [polypeptide binding]; other site
1097677000637	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1097677000638	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097677000639	catalytic residue [active]
1097677000640	Amidase; Region: Amidase; cl11426
1097677000641	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
1097677000642	allantoinase; Region: allantoinase; TIGR03178
1097677000643	active site
1097677000644	xanthine permease; Region: pbuX; TIGR03173
1097677000645	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1097677000646	Beta-lactamase; Region: Beta-lactamase; pfam00144
1097677000647	AAA domain; Region: AAA_32; pfam13654
1097677000648	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
1097677000649	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
1097677000650	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1097677000651	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1097677000652	Lsr2; Region: Lsr2; pfam11774
1097677000653	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1097677000654	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097677000655	Coenzyme A binding pocket [chemical binding]; other site
1097677000656	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1097677000657	homodimer interface [polypeptide binding]; other site
1097677000658	active site
1097677000659	TDP-binding site; other site
1097677000660	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1097677000661	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1097677000662	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1097677000663	Walker A/P-loop; other site
1097677000664	ATP binding site [chemical binding]; other site
1097677000665	Q-loop/lid; other site
1097677000666	ABC transporter signature motif; other site
1097677000667	Walker B; other site
1097677000668	D-loop; other site
1097677000669	H-loop/switch region; other site
1097677000670	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
1097677000671	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
1097677000672	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677000673	dimer interface [polypeptide binding]; other site
1097677000674	conserved gate region; other site
1097677000675	putative PBP binding loops; other site
1097677000676	ABC-ATPase subunit interface; other site
1097677000677	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677000678	dimer interface [polypeptide binding]; other site
1097677000679	conserved gate region; other site
1097677000680	putative PBP binding loops; other site
1097677000681	ABC-ATPase subunit interface; other site
1097677000682	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097677000683	dimerization interface [polypeptide binding]; other site
1097677000684	putative DNA binding site [nucleotide binding]; other site
1097677000685	putative Zn2+ binding site [ion binding]; other site
1097677000686	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097677000687	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1097677000688	Walker A motif; other site
1097677000689	ATP binding site [chemical binding]; other site
1097677000690	Walker B motif; other site
1097677000691	arginine finger; other site
1097677000692	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097677000693	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1097677000694	Walker A motif; other site
1097677000695	ATP binding site [chemical binding]; other site
1097677000696	Walker B motif; other site
1097677000697	arginine finger; other site
1097677000698	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1097677000699	Melibiase; Region: Melibiase; pfam02065
1097677000700	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097677000701	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097677000702	active site
1097677000703	catalytic tetrad [active]
1097677000704	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1097677000705	active site
1097677000706	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1097677000707	dimer interface [polypeptide binding]; other site
1097677000708	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1097677000709	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677000710	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1097677000711	Walker A/P-loop; other site
1097677000712	ATP binding site [chemical binding]; other site
1097677000713	Q-loop/lid; other site
1097677000714	ABC transporter signature motif; other site
1097677000715	Walker B; other site
1097677000716	D-loop; other site
1097677000717	H-loop/switch region; other site
1097677000718	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1097677000719	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677000720	Walker A/P-loop; other site
1097677000721	ATP binding site [chemical binding]; other site
1097677000722	Q-loop/lid; other site
1097677000723	ABC transporter signature motif; other site
1097677000724	Walker B; other site
1097677000725	D-loop; other site
1097677000726	H-loop/switch region; other site
1097677000727	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097677000728	S-adenosylmethionine binding site [chemical binding]; other site
1097677000729	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
1097677000730	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1097677000731	Cytochrome P450; Region: p450; cl12078
1097677000732	thiazolinyl imide reductase; Region: thiaz-red; TIGR01761
1097677000733	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097677000734	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097677000735	S-adenosylmethionine binding site [chemical binding]; other site
1097677000736	Protein of unknown function (DUF3438); Region: DUF3438; cl13372
1097677000737	Condensation domain; Region: Condensation; pfam00668
1097677000738	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1097677000739	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1097677000740	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1097677000741	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1097677000742	acyl-activating enzyme (AAE) consensus motif; other site
1097677000743	AMP binding site [chemical binding]; other site
1097677000744	Methyltransferase domain; Region: Methyltransf_12; pfam08242
1097677000745	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097677000746	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097677000747	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1097677000748	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1097677000749	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1097677000750	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1097677000751	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1097677000752	acyl-activating enzyme (AAE) consensus motif; other site
1097677000753	AMP binding site [chemical binding]; other site
1097677000754	Condensation domain; Region: Condensation; pfam00668
1097677000755	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1097677000756	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1097677000757	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1097677000758	acyl-activating enzyme (AAE) consensus motif; other site
1097677000759	AMP binding site [chemical binding]; other site
1097677000760	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
1097677000761	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097677000762	acyl-activating enzyme (AAE) consensus motif; other site
1097677000763	AMP binding site [chemical binding]; other site
1097677000764	active site
1097677000765	CoA binding site [chemical binding]; other site
1097677000766	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1097677000767	salicylate synthase MbtI; Reviewed; Region: PRK07912
1097677000768	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1097677000769	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
1097677000770	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1097677000771	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
1097677000772	active site
1097677000773	Asp23 family; Region: Asp23; pfam03780
1097677000774	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1097677000775	Ferritin-like domain; Region: Ferritin_2; pfam13668
1097677000776	spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886
1097677000777	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
1097677000778	active site
1097677000779	catalytic site [active]
1097677000780	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261
1097677000781	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
1097677000782	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
1097677000783	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1097677000784	NAD binding site [chemical binding]; other site
1097677000785	sugar binding site [chemical binding]; other site
1097677000786	divalent metal binding site [ion binding]; other site
1097677000787	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1097677000788	dimer interface [polypeptide binding]; other site
1097677000789	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1097677000790	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1097677000791	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1097677000792	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1097677000793	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1097677000794	substrate binding site [chemical binding]; other site
1097677000795	ATP binding site [chemical binding]; other site
1097677000796	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1097677000797	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097677000798	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677000799	putative PBP binding loops; other site
1097677000800	dimer interface [polypeptide binding]; other site
1097677000801	ABC-ATPase subunit interface; other site
1097677000802	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097677000803	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677000804	dimer interface [polypeptide binding]; other site
1097677000805	conserved gate region; other site
1097677000806	putative PBP binding loops; other site
1097677000807	ABC-ATPase subunit interface; other site
1097677000808	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1097677000809	active site
1097677000810	trimer interface [polypeptide binding]; other site
1097677000811	allosteric site; other site
1097677000812	active site lid [active]
1097677000813	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1097677000814	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
1097677000815	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1097677000816	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1097677000817	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
1097677000818	no orthologs in Cmm and Cms
1097677000819	Cmm ortholog CMM_0357; Cms ortholog CMS_0926
1097677000820	SnoaL-like domain; Region: SnoaL_4; cl17707
1097677000821	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1097677000822	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
1097677000823	intersubunit interface [polypeptide binding]; other site
1097677000824	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1097677000825	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1097677000826	ABC-ATPase subunit  interface; other site
1097677000827	dimer interface [polypeptide binding]; other site
1097677000828	putative PBP binding regions; other site
1097677000829	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1097677000830	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1097677000831	Walker A/P-loop; other site
1097677000832	ATP binding site [chemical binding]; other site
1097677000833	Q-loop/lid; other site
1097677000834	ABC transporter signature motif; other site
1097677000835	Walker B; other site
1097677000836	D-loop; other site
1097677000837	H-loop/switch region; other site
1097677000838	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097677000839	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677000840	NAD(P) binding site [chemical binding]; other site
1097677000841	active site
1097677000842	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1097677000843	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1097677000844	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097677000845	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677000846	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
1097677000847	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1097677000848	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1097677000849	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
1097677000850	tetramer interface [polypeptide binding]; other site
1097677000851	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677000852	catalytic residue [active]
1097677000853	Cmm ortholog CMM_0386; Cms ortholog CMS_0932
1097677000854	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1097677000855	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097677000856	Asp23 family; Region: Asp23; pfam03780
1097677000857	Asp23 family; Region: Asp23; cl00574
1097677000858	Septum formation; Region: Septum_form; pfam13845
1097677000859	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1097677000860	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1097677000861	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1097677000862	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677000863	Walker A/P-loop; other site
1097677000864	ATP binding site [chemical binding]; other site
1097677000865	Q-loop/lid; other site
1097677000866	ABC transporter signature motif; other site
1097677000867	Walker B; other site
1097677000868	D-loop; other site
1097677000869	H-loop/switch region; other site
1097677000870	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1097677000871	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1097677000872	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097677000873	classical (c) SDRs; Region: SDR_c; cd05233
1097677000874	NAD(P) binding site [chemical binding]; other site
1097677000875	active site
1097677000876	classical (c) SDRs; Region: SDR_c; cd05233
1097677000877	NAD(P) binding site [chemical binding]; other site
1097677000878	active site
1097677000879	Cmm ortholog CMM_0401; Cms ortholog CMS_0952
1097677000880	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097677000881	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677000882	active site
1097677000883	phosphorylation site [posttranslational modification]
1097677000884	intermolecular recognition site; other site
1097677000885	dimerization interface [polypeptide binding]; other site
1097677000886	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097677000887	DNA binding residues [nucleotide binding]
1097677000888	dimerization interface [polypeptide binding]; other site
1097677000889	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1097677000890	Histidine kinase; Region: HisKA_3; pfam07730
1097677000891	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1097677000892	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677000893	putative substrate translocation pore; other site
1097677000894	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677000895	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1097677000896	TAP-like protein; Region: Abhydrolase_4; pfam08386
1097677000897	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1097677000898	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097677000899	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1097677000900	prenyltransferase; Provisional; Region: ubiA; PRK13595
1097677000901	UbiA prenyltransferase family; Region: UbiA; pfam01040
1097677000902	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1097677000903	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1097677000904	homodimer interface [polypeptide binding]; other site
1097677000905	active site
1097677000906	TDP-binding site; other site
1097677000907	acceptor substrate-binding pocket; other site
1097677000908	short chain dehydrogenase; Validated; Region: PRK08264
1097677000909	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677000910	NAD(P) binding site [chemical binding]; other site
1097677000911	active site
1097677000912	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1097677000913	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1097677000914	DNA binding residues [nucleotide binding]
1097677000915	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
1097677000916	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1097677000917	substrate binding [chemical binding]; other site
1097677000918	active site
1097677000919	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1097677000920	Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251
1097677000921	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1097677000922	substrate binding [chemical binding]; other site
1097677000923	active site
1097677000924	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097677000925	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097677000926	DNA binding site [nucleotide binding]
1097677000927	domain linker motif; other site
1097677000928	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
1097677000929	putative ligand binding site [chemical binding]; other site
1097677000930	putative dimerization interface [polypeptide binding]; other site
1097677000931	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097677000932	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677000933	dimer interface [polypeptide binding]; other site
1097677000934	conserved gate region; other site
1097677000935	putative PBP binding loops; other site
1097677000936	ABC-ATPase subunit interface; other site
1097677000937	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677000938	dimer interface [polypeptide binding]; other site
1097677000939	conserved gate region; other site
1097677000940	putative PBP binding loops; other site
1097677000941	ABC-ATPase subunit interface; other site
1097677000942	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1097677000943	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1097677000944	Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995
1097677000945	active site
1097677000946	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
1097677000947	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097677000948	MarR family; Region: MarR; pfam01047
1097677000949	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1097677000950	Predicted membrane protein [Function unknown]; Region: COG4270
1097677000951	RES domain; Region: RES; pfam08808
1097677000952	Cmm ortholog; Cms ortholog CMS_0977
1097677000953	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1097677000954	dimanganese center [ion binding]; other site
1097677000955	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
1097677000956	active site
1097677000957	catalytic triad [active]
1097677000958	oxyanion hole [active]
1097677000959	GAF domain; Region: GAF; pfam01590
1097677000960	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1097677000961	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097677000962	putative phosphoketolase; Provisional; Region: PRK05261
1097677000963	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
1097677000964	TPP-binding site; other site
1097677000965	XFP C-terminal domain; Region: XFP_C; pfam09363
1097677000966	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1097677000967	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097677000968	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1097677000969	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1097677000970	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1097677000971	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097677000972	Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382
1097677000973	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097677000974	MarR family; Region: MarR_2; pfam12802
1097677000975	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097677000976	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097677000977	dimerization interface [polypeptide binding]; other site
1097677000978	putative DNA binding site [nucleotide binding]; other site
1097677000979	putative Zn2+ binding site [ion binding]; other site
1097677000980	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677000981	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097677000982	putative substrate translocation pore; other site
1097677000983	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677000984	no orthologs in Cmm and Cms
1097677000985	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1097677000986	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097677000987	active site
1097677000988	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
1097677000989	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1097677000990	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1097677000991	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677000992	active site
1097677000993	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1097677000994	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1097677000995	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1097677000996	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
1097677000997	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
1097677000998	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097677000999	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677001000	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1097677001001	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677001002	putative substrate translocation pore; other site
1097677001003	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1097677001004	putative hydrophobic ligand binding site [chemical binding]; other site
1097677001005	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1097677001006	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097677001007	non-specific DNA binding site [nucleotide binding]; other site
1097677001008	salt bridge; other site
1097677001009	sequence-specific DNA binding site [nucleotide binding]; other site
1097677001010	HipA N-terminal domain; Region: Couple_hipA; pfam13657
1097677001011	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1097677001012	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1097677001013	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
1097677001014	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
1097677001015	Predicted permeases [General function prediction only]; Region: COG0679
1097677001016	Cmm ortholog CMM_0463; Cms ortholog CMS_0213
1097677001017	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677001018	NAD(P) binding site [chemical binding]; other site
1097677001019	active site
1097677001020	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
1097677001021	active site
1097677001022	Zn binding site [ion binding]; other site
1097677001023	TM1410 hypothetical-related protein; Region: DUF297; cl00997
1097677001024	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
1097677001025	oxidoreductase; Provisional; Region: PRK06128
1097677001026	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677001027	NAD(P) binding site [chemical binding]; other site
1097677001028	active site
1097677001029	MOSC domain; Region: MOSC; pfam03473
1097677001030	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1097677001031	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097677001032	dimer interface [polypeptide binding]; other site
1097677001033	phosphorylation site [posttranslational modification]
1097677001034	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097677001035	ATP binding site [chemical binding]; other site
1097677001036	Mg2+ binding site [ion binding]; other site
1097677001037	G-X-G motif; other site
1097677001038	Hpt domain; Region: Hpt; pfam01627
1097677001039	putative binding surface; other site
1097677001040	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097677001041	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677001042	active site
1097677001043	phosphorylation site [posttranslational modification]
1097677001044	intermolecular recognition site; other site
1097677001045	dimerization interface [polypeptide binding]; other site
1097677001046	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097677001047	DNA binding site [nucleotide binding]
1097677001048	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1097677001049	putative catalytic site [active]
1097677001050	putative phosphate binding site [ion binding]; other site
1097677001051	active site
1097677001052	metal binding site A [ion binding]; metal-binding site
1097677001053	DNA binding site [nucleotide binding]
1097677001054	putative AP binding site [nucleotide binding]; other site
1097677001055	putative metal binding site B [ion binding]; other site
1097677001056	Asp23 family; Region: Asp23; pfam03780
1097677001057	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1097677001058	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097677001059	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097677001060	DNA binding residues [nucleotide binding]
1097677001061	Asp23 family; Region: Asp23; pfam03780
1097677001062	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1097677001063	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1097677001064	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1097677001065	active site
1097677001066	Septum formation; Region: Septum_form; pfam13845
1097677001067	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097677001068	UMP phosphatase; Provisional; Region: PRK10444
1097677001069	active site
1097677001070	motif I; other site
1097677001071	motif II; other site
1097677001072	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097677001073	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1097677001074	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1097677001075	active site
1097677001076	metal binding site [ion binding]; metal-binding site
1097677001077	hexamer interface [polypeptide binding]; other site
1097677001078	CsbD-like; Region: CsbD; pfam05532
1097677001079	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1097677001080	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1097677001081	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097677001082	ATP binding site [chemical binding]; other site
1097677001083	putative Mg++ binding site [ion binding]; other site
1097677001084	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097677001085	nucleotide binding region [chemical binding]; other site
1097677001086	ATP-binding site [chemical binding]; other site
1097677001087	DNA methylase; Region: N6_N4_Mtase; cl17433
1097677001088	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1097677001089	DNA methylase; Region: N6_N4_Mtase; pfam01555
1097677001090	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1097677001091	kynureninase; Region: kynureninase; TIGR01814
1097677001092	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097677001093	catalytic residue [active]
1097677001094	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097677001095	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097677001096	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1097677001097	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1097677001098	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1097677001099	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1097677001100	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1097677001101	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1097677001102	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1097677001103	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1097677001104	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1097677001105	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1097677001106	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1097677001107	Pro-kumamolisin, activation domain; Region: Pro-kuma_activ; smart00944
1097677001108	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
1097677001109	active site
1097677001110	catalytic triad [active]
1097677001111	calcium binding site [ion binding]; other site
1097677001112	Cmm ortholog; Cms ortholog CMS_0262
1097677001113	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097677001114	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677001115	Cmm ortholog CMM_0504; Cms ortholog CMS_0264
1097677001116	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
1097677001117	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1097677001118	Predicted acetyltransferase [General function prediction only]; Region: COG2388
1097677001119	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
1097677001120	Putative amidase domain; Region: Amidase_6; pfam12671
1097677001121	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
1097677001122	phosphoglucomutase; Validated; Region: PRK07564
1097677001123	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
1097677001124	active site
1097677001125	substrate binding site [chemical binding]; other site
1097677001126	metal binding site [ion binding]; metal-binding site
1097677001127	Prephenate dehydratase; Region: PDT; pfam00800
1097677001128	prephenate dehydratase; Provisional; Region: PRK11898
1097677001129	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1097677001130	putative L-Phe binding site [chemical binding]; other site
1097677001131	seryl-tRNA synthetase; Provisional; Region: PRK05431
1097677001132	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1097677001133	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1097677001134	dimer interface [polypeptide binding]; other site
1097677001135	active site
1097677001136	motif 1; other site
1097677001137	motif 2; other site
1097677001138	motif 3; other site
1097677001139	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1097677001140	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097677001141	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
1097677001142	no ortholog in Cmm and Cms
1097677001143	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1097677001144	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1097677001145	Walker A/P-loop; other site
1097677001146	ATP binding site [chemical binding]; other site
1097677001147	Q-loop/lid; other site
1097677001148	ABC transporter signature motif; other site
1097677001149	Walker B; other site
1097677001150	D-loop; other site
1097677001151	H-loop/switch region; other site
1097677001152	no orthologs in Cmm and Cms
1097677001153	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1097677001154	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677001155	Walker A/P-loop; other site
1097677001156	ATP binding site [chemical binding]; other site
1097677001157	Q-loop/lid; other site
1097677001158	ABC transporter signature motif; other site
1097677001159	Walker B; other site
1097677001160	D-loop; other site
1097677001161	H-loop/switch region; other site
1097677001162	Phospholipid methyltransferase; Region: PEMT; cl17370
1097677001163	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097677001164	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097677001165	DNA binding site [nucleotide binding]
1097677001166	domain linker motif; other site
1097677001167	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1097677001168	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1097677001169	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097677001170	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097677001171	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1097677001172	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1097677001173	active site
1097677001174	catalytic site [active]
1097677001175	no orthologs in Cmm and Cms
1097677001176	Predicted transcriptional regulators [Transcription]; Region: COG1695
1097677001177	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1097677001178	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1097677001179	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
1097677001180	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097677001181	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097677001182	active site
1097677001183	catalytic tetrad [active]
1097677001184	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1097677001185	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1097677001186	putative acyl-acceptor binding pocket; other site
1097677001187	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1097677001188	tetramerization interface [polypeptide binding]; other site
1097677001189	active site
1097677001190	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1097677001191	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1097677001192	DNA photolyase; Region: DNA_photolyase; pfam00875
1097677001193	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1097677001194	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1097677001195	active site
1097677001196	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097677001197	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1097677001198	MarR family; Region: MarR_2; cl17246
1097677001199	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097677001200	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097677001201	DNA binding site [nucleotide binding]
1097677001202	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1097677001203	active site
1097677001204	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1097677001205	nucleoside/Zn binding site; other site
1097677001206	dimer interface [polypeptide binding]; other site
1097677001207	catalytic motif [active]
1097677001208	Cation efflux family; Region: Cation_efflux; pfam01545
1097677001209	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1097677001210	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1097677001211	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1097677001212	TrkA-N domain; Region: TrkA_N; pfam02254
1097677001213	TrkA-C domain; Region: TrkA_C; pfam02080
1097677001214	Cation transport protein; Region: TrkH; cl17365
1097677001215	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1097677001216	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1097677001217	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097677001218	putative DNA binding site [nucleotide binding]; other site
1097677001219	putative Zn2+ binding site [ion binding]; other site
1097677001220	DNA binding domain, excisionase family; Region: excise; TIGR01764
1097677001221	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
1097677001222	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1097677001223	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1097677001224	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1097677001225	dimerization interface [polypeptide binding]; other site
1097677001226	putative DNA binding site [nucleotide binding]; other site
1097677001227	putative Zn2+ binding site [ion binding]; other site
1097677001228	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1097677001229	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
1097677001230	Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop.  Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cd04100
1097677001231	Dimer interface [polypeptide binding]; other site
1097677001232	anticodon binding site; other site
1097677001233	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1097677001234	motif 1; other site
1097677001235	dimer interface [polypeptide binding]; other site
1097677001236	active site
1097677001237	motif 2; other site
1097677001238	motif 3; other site
1097677001239	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1097677001240	putative active site [active]
1097677001241	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
1097677001242	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1097677001243	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1097677001244	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
1097677001245	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677001246	Walker A/P-loop; other site
1097677001247	ATP binding site [chemical binding]; other site
1097677001248	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
1097677001249	Q-loop/lid; other site
1097677001250	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677001251	ABC transporter signature motif; other site
1097677001252	Walker B; other site
1097677001253	D-loop; other site
1097677001254	H-loop/switch region; other site
1097677001255	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677001256	Walker A/P-loop; other site
1097677001257	ATP binding site [chemical binding]; other site
1097677001258	Q-loop/lid; other site
1097677001259	ABC transporter signature motif; other site
1097677001260	Walker B; other site
1097677001261	D-loop; other site
1097677001262	H-loop/switch region; other site
1097677001263	acyl transferase; Provisional; Region: luxD; PRK13604
1097677001264	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1097677001265	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1097677001266	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097677001267	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1097677001268	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097677001269	DNA binding residues [nucleotide binding]
1097677001270	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1097677001271	catalytic core [active]
1097677001272	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1097677001273	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1097677001274	catalytic residues [active]
1097677001275	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1097677001276	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1097677001277	ResB-like family; Region: ResB; pfam05140
1097677001278	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
1097677001279	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1097677001280	O-succinylbenzoate synthase; Provisional; Region: PRK02901
1097677001281	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1097677001282	active site
1097677001283	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097677001284	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1097677001285	substrate binding site [chemical binding]; other site
1097677001286	oxyanion hole (OAH) forming residues; other site
1097677001287	trimer interface [polypeptide binding]; other site
1097677001288	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097677001289	active site
1097677001290	AMP binding site [chemical binding]; other site
1097677001291	acyl-activating enzyme (AAE) consensus motif; other site
1097677001292	CoA binding site [chemical binding]; other site
1097677001293	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1097677001294	nudix motif; other site
1097677001295	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1097677001296	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1097677001297	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1097677001298	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1097677001299	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1097677001300	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1097677001301	NAD(P) binding pocket [chemical binding]; other site
1097677001302	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1097677001303	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1097677001304	substrate binding site [chemical binding]; other site
1097677001305	active site
1097677001306	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1097677001307	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1097677001308	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
1097677001309	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
1097677001310	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
1097677001311	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1097677001312	TIGR03086 family protein; Region: TIGR03086
1097677001313	Chlorite dismutase; Region: Chlor_dismutase; pfam06778
1097677001314	ferrochelatase; Reviewed; Region: hemH; PRK00035
1097677001315	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1097677001316	C-terminal domain interface [polypeptide binding]; other site
1097677001317	active site
1097677001318	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1097677001319	active site
1097677001320	N-terminal domain interface [polypeptide binding]; other site
1097677001321	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1097677001322	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
1097677001323	domain interfaces; other site
1097677001324	active site
1097677001325	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1097677001326	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1097677001327	active site
1097677001328	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1097677001329	dimer interface [polypeptide binding]; other site
1097677001330	active site
1097677001331	Schiff base residues; other site
1097677001332	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1097677001333	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1097677001334	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097677001335	catalytic residue [active]
1097677001336	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1097677001337	putative FMN binding site [chemical binding]; other site
1097677001338	NADPH bind site [chemical binding]; other site
1097677001339	Cupin superfamily protein; Region: Cupin_4; pfam08007
1097677001340	H+ Antiporter protein; Region: 2A0121; TIGR00900
1097677001341	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
1097677001342	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1097677001343	active site
1097677001344	substrate binding site [chemical binding]; other site
1097677001345	Mg2+ binding site [ion binding]; other site
1097677001346	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
1097677001347	heme binding pocket [chemical binding]; other site
1097677001348	heme ligand [chemical binding]; other site
1097677001349	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
1097677001350	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
1097677001351	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1097677001352	NADP binding site [chemical binding]; other site
1097677001353	dimer interface [polypeptide binding]; other site
1097677001354	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1097677001355	phosphofructokinase; Region: PFK_mixed; TIGR02483
1097677001356	active site
1097677001357	ADP/pyrophosphate binding site [chemical binding]; other site
1097677001358	dimerization interface [polypeptide binding]; other site
1097677001359	allosteric effector site; other site
1097677001360	fructose-1,6-bisphosphate binding site; other site
1097677001361	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
1097677001362	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1097677001363	active site
1097677001364	Cmm ortholog CMM_0606; no Cms ortholog
1097677001365	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1097677001366	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1097677001367	minor groove reading motif; other site
1097677001368	helix-hairpin-helix signature motif; other site
1097677001369	active site
1097677001370	Thioredoxin; Region: Thioredoxin_4; pfam13462
1097677001371	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1097677001372	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
1097677001373	active site
1097677001374	catalytic residues [active]
1097677001375	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1097677001376	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097677001377	active site
1097677001378	metal binding site [ion binding]; metal-binding site
1097677001379	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097677001380	MarR family; Region: MarR; pfam01047
1097677001381	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1097677001382	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1097677001383	substrate binding [chemical binding]; other site
1097677001384	active site
1097677001385	Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997
1097677001386	active site
1097677001387	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
1097677001388	CopC domain; Region: CopC; pfam04234
1097677001389	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097677001390	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
1097677001391	putative dimerization interface [polypeptide binding]; other site
1097677001392	Proline dehydrogenase; Region: Pro_dh; cl03282
1097677001393	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
1097677001394	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097677001395	Glutamate binding site [chemical binding]; other site
1097677001396	NAD binding site [chemical binding]; other site
1097677001397	catalytic residues [active]
1097677001398	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1097677001399	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1097677001400	Peptidase family M1; Region: Peptidase_M1; pfam01433
1097677001401	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
1097677001402	Zn binding site [ion binding]; other site
1097677001403	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097677001404	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1097677001405	acyl-activating enzyme (AAE) consensus motif; other site
1097677001406	AMP binding site [chemical binding]; other site
1097677001407	active site
1097677001408	CoA binding site [chemical binding]; other site
1097677001409	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097677001410	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
1097677001411	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1097677001412	putative trimer interface [polypeptide binding]; other site
1097677001413	putative CoA binding site [chemical binding]; other site
1097677001414	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1097677001415	putative trimer interface [polypeptide binding]; other site
1097677001416	putative CoA binding site [chemical binding]; other site
1097677001417	Predicted transcriptional regulators [Transcription]; Region: COG1725
1097677001418	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097677001419	DNA-binding site [nucleotide binding]; DNA binding site
1097677001420	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1097677001421	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1097677001422	AsnC family; Region: AsnC_trans_reg; pfam01037
1097677001423	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
1097677001424	Amidinotransferase; Region: Amidinotransf; pfam02274
1097677001425	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
1097677001426	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1097677001427	inhibitor-cofactor binding pocket; inhibition site
1097677001428	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677001429	catalytic residue [active]
1097677001430	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1097677001431	EamA-like transporter family; Region: EamA; pfam00892
1097677001432	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097677001433	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677001434	NAD(P) binding site [chemical binding]; other site
1097677001435	active site
1097677001436	probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885
1097677001437	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1097677001438	Peptidase family M23; Region: Peptidase_M23; pfam01551
1097677001439	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
1097677001440	active site
1097677001441	catalytic triad [active]
1097677001442	oxyanion hole [active]
1097677001443	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
1097677001444	putative hydrophobic ligand binding site [chemical binding]; other site
1097677001445	Cmm ortholog CMM_0642; Cms homolog CMS_0499
1097677001446	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1097677001447	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1097677001448	FMN binding site [chemical binding]; other site
1097677001449	active site
1097677001450	substrate binding site [chemical binding]; other site
1097677001451	catalytic residue [active]
1097677001452	Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870
1097677001453	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097677001454	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677001455	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097677001456	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677001457	putative substrate translocation pore; other site
1097677001458	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677001459	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
1097677001460	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1097677001461	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
1097677001462	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1097677001463	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1097677001464	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1097677001465	NADP binding site [chemical binding]; other site
1097677001466	dimer interface [polypeptide binding]; other site
1097677001467	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1097677001468	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1097677001469	dimer interface [polypeptide binding]; other site
1097677001470	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677001471	catalytic residue [active]
1097677001472	serine O-acetyltransferase; Region: cysE; TIGR01172
1097677001473	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1097677001474	trimer interface [polypeptide binding]; other site
1097677001475	active site
1097677001476	substrate binding site [chemical binding]; other site
1097677001477	CoA binding site [chemical binding]; other site
1097677001478	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1097677001479	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1097677001480	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1097677001481	YrhK-like protein; Region: YrhK; pfam14145
1097677001482	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1097677001483	adenosine deaminase; Provisional; Region: PRK09358
1097677001484	active site
1097677001485	no orthologs in Cmm and Cms
1097677001486	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1097677001487	catalytic core [active]
1097677001488	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1097677001489	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1097677001490	putative NAD(P) binding site [chemical binding]; other site
1097677001491	putative substrate binding site [chemical binding]; other site
1097677001492	catalytic Zn binding site [ion binding]; other site
1097677001493	structural Zn binding site [ion binding]; other site
1097677001494	dimer interface [polypeptide binding]; other site
1097677001495	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1097677001496	substrate binding pocket [chemical binding]; other site
1097677001497	catalytic triad [active]
1097677001498	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
1097677001499	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1097677001500	DNA binding residues [nucleotide binding]
1097677001501	Ferredoxin [Energy production and conversion]; Region: COG1146
1097677001502	4Fe-4S binding domain; Region: Fer4; pfam00037
1097677001503	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1097677001504	HipA N-terminal domain; Region: Couple_hipA; pfam13657
1097677001505	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1097677001506	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1097677001507	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097677001508	non-specific DNA binding site [nucleotide binding]; other site
1097677001509	salt bridge; other site
1097677001510	sequence-specific DNA binding site [nucleotide binding]; other site
1097677001511	Cmm ortholog CMM_0667; Cms ortholog CMS_2154
1097677001512	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
1097677001513	Cmm ortholog CMM_0670; no Cms ortholog
1097677001514	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1097677001515	Predicted membrane protein [Function unknown]; Region: COG1511
1097677001516	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1097677001517	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097677001518	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677001519	Helix-turn-helix domain; Region: HTH_18; pfam12833
1097677001520	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1097677001521	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677001522	Walker A/P-loop; other site
1097677001523	ATP binding site [chemical binding]; other site
1097677001524	Q-loop/lid; other site
1097677001525	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1097677001526	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677001527	ABC transporter signature motif; other site
1097677001528	Walker B; other site
1097677001529	D-loop; other site
1097677001530	H-loop/switch region; other site
1097677001531	exonuclease subunit SbcD; Provisional; Region: PRK10966
1097677001532	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1097677001533	active site
1097677001534	metal binding site [ion binding]; metal-binding site
1097677001535	DNA binding site [nucleotide binding]
1097677001536	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1097677001537	short chain dehydrogenase; Provisional; Region: PRK08263
1097677001538	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1097677001539	NADP binding site [chemical binding]; other site
1097677001540	active site
1097677001541	steroid binding site; other site
1097677001542	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
1097677001543	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1097677001544	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1097677001545	GDP-binding site [chemical binding]; other site
1097677001546	ACT binding site; other site
1097677001547	IMP binding site; other site
1097677001548	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097677001549	MarR family; Region: MarR_2; pfam12802
1097677001550	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097677001551	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1097677001552	active site
1097677001553	Sensors of blue-light using FAD; Region: BLUF; pfam04940
1097677001554	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097677001555	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097677001556	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097677001557	dimer interface [polypeptide binding]; other site
1097677001558	phosphorylation site [posttranslational modification]
1097677001559	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097677001560	ATP binding site [chemical binding]; other site
1097677001561	Mg2+ binding site [ion binding]; other site
1097677001562	G-X-G motif; other site
1097677001563	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097677001564	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677001565	active site
1097677001566	phosphorylation site [posttranslational modification]
1097677001567	intermolecular recognition site; other site
1097677001568	dimerization interface [polypeptide binding]; other site
1097677001569	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097677001570	DNA binding site [nucleotide binding]
1097677001571	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1097677001572	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1097677001573	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
1097677001574	putative dimer interface [polypeptide binding]; other site
1097677001575	ligand binding site [chemical binding]; other site
1097677001576	Zn binding site [ion binding]; other site
1097677001577	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1097677001578	Beta-lactamase; Region: Beta-lactamase; pfam00144
1097677001579	Histidine kinase; Region: HisKA_3; pfam07730
1097677001580	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1097677001581	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097677001582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677001583	active site
1097677001584	phosphorylation site [posttranslational modification]
1097677001585	intermolecular recognition site; other site
1097677001586	dimerization interface [polypeptide binding]; other site
1097677001587	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097677001588	DNA binding residues [nucleotide binding]
1097677001589	dimerization interface [polypeptide binding]; other site
1097677001590	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1097677001591	chorismate mutase; Provisional; Region: PRK09239
1097677001592	Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144
1097677001593	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1097677001594	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
1097677001595	putative catalytic site [active]
1097677001596	putative metal binding site [ion binding]; other site
1097677001597	putative phosphate binding site [ion binding]; other site
1097677001598	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1097677001599	putative active site [active]
1097677001600	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
1097677001601	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1097677001602	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1097677001603	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097677001604	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
1097677001605	putative ADP-binding pocket [chemical binding]; other site
1097677001606	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097677001607	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1097677001608	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1097677001609	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1097677001610	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1097677001611	active site
1097677001612	Chain length determinant protein; Region: Wzz; cl15801
1097677001613	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1097677001614	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097677001615	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1097677001616	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1097677001617	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
1097677001618	active site
1097677001619	catalytic triad [active]
1097677001620	oxyanion hole [active]
1097677001621	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
1097677001622	putative catalytic site [active]
1097677001623	putative metal binding site [ion binding]; other site
1097677001624	putative phosphate binding site [ion binding]; other site
1097677001625	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1097677001626	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
1097677001627	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1097677001628	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1097677001629	dimerization interface [polypeptide binding]; other site
1097677001630	ATP binding site [chemical binding]; other site
1097677001631	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1097677001632	dimerization interface [polypeptide binding]; other site
1097677001633	ATP binding site [chemical binding]; other site
1097677001634	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1097677001635	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1097677001636	putative active site [active]
1097677001637	catalytic triad [active]
1097677001638	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
1097677001639	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
1097677001640	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677001641	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677001642	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1097677001643	homotrimer interaction site [polypeptide binding]; other site
1097677001644	putative active site [active]
1097677001645	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
1097677001646	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097677001647	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1097677001648	DNA-binding site [nucleotide binding]; DNA binding site
1097677001649	FCD domain; Region: FCD; pfam07729
1097677001650	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1097677001651	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
1097677001652	putative active site [active]
1097677001653	catalytic triad [active]
1097677001654	putative dimer interface [polypeptide binding]; other site
1097677001655	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1097677001656	B12 binding site [chemical binding]; other site
1097677001657	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
1097677001658	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097677001659	FeS/SAM binding site; other site
1097677001660	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097677001661	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097677001662	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097677001663	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1097677001664	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1097677001665	NAD binding site [chemical binding]; other site
1097677001666	NAD binding site [chemical binding]; other site
1097677001667	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097677001668	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097677001669	active site
1097677001670	catalytic tetrad [active]
1097677001671	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1097677001672	metal binding site 2 [ion binding]; metal-binding site
1097677001673	putative DNA binding helix; other site
1097677001674	metal binding site 1 [ion binding]; metal-binding site
1097677001675	dimer interface [polypeptide binding]; other site
1097677001676	structural Zn2+ binding site [ion binding]; other site
1097677001677	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1097677001678	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1097677001679	tetramer interface [polypeptide binding]; other site
1097677001680	heme binding pocket [chemical binding]; other site
1097677001681	NADPH binding site [chemical binding]; other site
1097677001682	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1097677001683	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097677001684	Coenzyme A binding pocket [chemical binding]; other site
1097677001685	Nodulation protein A (NodA); Region: NodA; cl17421
1097677001686	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1097677001687	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1097677001688	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1097677001689	Domain of unknown function DUF21; Region: DUF21; pfam01595
1097677001690	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1097677001691	Transporter associated domain; Region: CorC_HlyC; smart01091
1097677001692	Cmm ortholog CMM_0747; no Cms ortholog
1097677001693	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1097677001694	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097677001695	active site
1097677001696	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097677001697	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097677001698	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
1097677001699	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097677001700	S-adenosylmethionine binding site [chemical binding]; other site
1097677001701	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1097677001702	active site
1097677001703	ATP binding site [chemical binding]; other site
1097677001704	substrate binding site [chemical binding]; other site
1097677001705	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1097677001706	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1097677001707	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1097677001708	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1097677001709	amidophosphoribosyltransferase; Provisional; Region: PRK09246
1097677001710	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1097677001711	active site
1097677001712	tetramer interface [polypeptide binding]; other site
1097677001713	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1097677001714	active site
1097677001715	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1097677001716	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1097677001717	dimerization interface [polypeptide binding]; other site
1097677001718	putative ATP binding site [chemical binding]; other site
1097677001719	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
1097677001720	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1097677001721	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097677001722	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1097677001723	Predicted membrane protein [Function unknown]; Region: COG2364
1097677001724	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1097677001725	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1097677001726	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097677001727	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1097677001728	DNA-binding site [nucleotide binding]; DNA binding site
1097677001729	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097677001730	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677001731	homodimer interface [polypeptide binding]; other site
1097677001732	catalytic residue [active]
1097677001733	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1097677001734	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1097677001735	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1097677001736	active site
1097677001737	catalytic site [active]
1097677001738	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1097677001739	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
1097677001740	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
1097677001741	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1097677001742	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1097677001743	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1097677001744	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1097677001745	ATP binding site [chemical binding]; other site
1097677001746	Mg++ binding site [ion binding]; other site
1097677001747	motif III; other site
1097677001748	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097677001749	nucleotide binding region [chemical binding]; other site
1097677001750	ATP-binding site [chemical binding]; other site
1097677001751	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1097677001752	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1097677001753	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1097677001754	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097677001755	Coenzyme A binding pocket [chemical binding]; other site
1097677001756	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1097677001757	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1097677001758	substrate binding site [chemical binding]; other site
1097677001759	ATP binding site [chemical binding]; other site
1097677001760	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1097677001761	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1097677001762	tetrameric interface [polypeptide binding]; other site
1097677001763	NAD binding site [chemical binding]; other site
1097677001764	catalytic residues [active]
1097677001765	KduI/IolB family; Region: KduI; pfam04962
1097677001766	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1097677001767	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1097677001768	PYR/PP interface [polypeptide binding]; other site
1097677001769	dimer interface [polypeptide binding]; other site
1097677001770	TPP binding site [chemical binding]; other site
1097677001771	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097677001772	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
1097677001773	TPP-binding site; other site
1097677001774	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1097677001775	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1097677001776	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1097677001777	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1097677001778	no orthologs in Cmm and Cms
1097677001779	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097677001780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677001781	active site
1097677001782	phosphorylation site [posttranslational modification]
1097677001783	intermolecular recognition site; other site
1097677001784	dimerization interface [polypeptide binding]; other site
1097677001785	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097677001786	DNA binding residues [nucleotide binding]
1097677001787	dimerization interface [polypeptide binding]; other site
1097677001788	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097677001789	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097677001790	DNA-binding site [nucleotide binding]; DNA binding site
1097677001791	FCD domain; Region: FCD; pfam07729
1097677001792	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1097677001793	substrate binding site [chemical binding]; other site
1097677001794	dimer interface [polypeptide binding]; other site
1097677001795	catalytic triad [active]
1097677001796	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
1097677001797	dihydroxyacetone kinase; Provisional; Region: PRK14479
1097677001798	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
1097677001799	DAK2 domain; Region: Dak2; pfam02734
1097677001800	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1097677001801	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1097677001802	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1097677001803	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097677001804	DNA-binding site [nucleotide binding]; DNA binding site
1097677001805	UTRA domain; Region: UTRA; pfam07702
1097677001806	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677001807	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
1097677001808	Walker A/P-loop; other site
1097677001809	ATP binding site [chemical binding]; other site
1097677001810	Q-loop/lid; other site
1097677001811	ABC transporter signature motif; other site
1097677001812	Walker B; other site
1097677001813	D-loop; other site
1097677001814	H-loop/switch region; other site
1097677001815	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097677001816	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097677001817	TM-ABC transporter signature motif; other site
1097677001818	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
1097677001819	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1097677001820	putative ligand binding site [chemical binding]; other site
1097677001821	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097677001822	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097677001823	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1097677001824	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1097677001825	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1097677001826	generic binding surface II; other site
1097677001827	generic binding surface I; other site
1097677001828	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
1097677001829	putative active site [active]
1097677001830	putative catalytic site [active]
1097677001831	putative Mg binding site IVb [ion binding]; other site
1097677001832	putative phosphate binding site [ion binding]; other site
1097677001833	putative DNA binding site [nucleotide binding]; other site
1097677001834	putative Mg binding site IVa [ion binding]; other site
1097677001835	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1097677001836	catalytic residues [active]
1097677001837	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1097677001838	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097677001839	ATP binding site [chemical binding]; other site
1097677001840	putative Mg++ binding site [ion binding]; other site
1097677001841	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097677001842	nucleotide binding region [chemical binding]; other site
1097677001843	ATP-binding site [chemical binding]; other site
1097677001844	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1097677001845	HRDC domain; Region: HRDC; pfam00570
1097677001846	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
1097677001847	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
1097677001848	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
1097677001849	peptide binding site [polypeptide binding]; other site
1097677001850	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1097677001851	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
1097677001852	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677001853	dimer interface [polypeptide binding]; other site
1097677001854	conserved gate region; other site
1097677001855	putative PBP binding loops; other site
1097677001856	ABC-ATPase subunit interface; other site
1097677001857	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1097677001858	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677001859	dimer interface [polypeptide binding]; other site
1097677001860	conserved gate region; other site
1097677001861	putative PBP binding loops; other site
1097677001862	ABC-ATPase subunit interface; other site
1097677001863	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1097677001864	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097677001865	Walker A/P-loop; other site
1097677001866	ATP binding site [chemical binding]; other site
1097677001867	Q-loop/lid; other site
1097677001868	ABC transporter signature motif; other site
1097677001869	Walker B; other site
1097677001870	D-loop; other site
1097677001871	H-loop/switch region; other site
1097677001872	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1097677001873	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1097677001874	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097677001875	Walker A/P-loop; other site
1097677001876	ATP binding site [chemical binding]; other site
1097677001877	Q-loop/lid; other site
1097677001878	ABC transporter signature motif; other site
1097677001879	Walker B; other site
1097677001880	D-loop; other site
1097677001881	H-loop/switch region; other site
1097677001882	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1097677001883	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
1097677001884	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
1097677001885	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1097677001886	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1097677001887	active site
1097677001888	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
1097677001889	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097677001890	DNA-binding site [nucleotide binding]; DNA binding site
1097677001891	FCD domain; Region: FCD; pfam07729
1097677001892	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1097677001893	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1097677001894	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
1097677001895	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1097677001896	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1097677001897	inhibitor site; inhibition site
1097677001898	active site
1097677001899	dimer interface [polypeptide binding]; other site
1097677001900	catalytic residue [active]
1097677001901	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1097677001902	Proline racemase; Region: Pro_racemase; pfam05544
1097677001903	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1097677001904	NAD(P) binding site [chemical binding]; other site
1097677001905	catalytic residues [active]
1097677001906	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1097677001907	acyl-coenzyme A oxidase; Region: PLN02636
1097677001908	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097677001909	active site
1097677001910	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
1097677001911	PemK-like protein; Region: PemK; pfam02452
1097677001912	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1097677001913	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
1097677001914	active site
1097677001915	catalytic triad [active]
1097677001916	oxyanion hole [active]
1097677001917	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
1097677001918	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1097677001919	active site
1097677001920	HIGH motif; other site
1097677001921	nucleotide binding site [chemical binding]; other site
1097677001922	Right handed beta helix region; Region: Beta_helix; pfam13229
1097677001923	Cmm ortholog CMM_0820; Cms ortholog CMS_0079
1097677001924	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1097677001925	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1097677001926	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
1097677001927	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097677001928	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1097677001929	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1097677001930	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097677001931	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110
1097677001932	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110
1097677001933	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
1097677001934	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
1097677001935	Chain length determinant protein; Region: Wzz; cl15801
1097677001936	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1097677001937	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1097677001938	Nucleotide binding site [chemical binding]; other site
1097677001939	P loop; other site
1097677001940	DTAP/Switch II; other site
1097677001941	Switch I; other site
1097677001942	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1097677001943	active site
1097677001944	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1097677001945	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1097677001946	Probable Catalytic site; other site
1097677001947	metal-binding site
1097677001948	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1097677001949	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1097677001950	active site
1097677001951	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097677001952	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1097677001953	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1097677001954	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
1097677001955	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677001956	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097677001957	NAD(P) binding site [chemical binding]; other site
1097677001958	active site
1097677001959	MarR family; Region: MarR; pfam01047
1097677001960	Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844
1097677001961	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1097677001962	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1097677001963	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
1097677001964	putative ADP-ribose binding site [chemical binding]; other site
1097677001965	putative active site [active]
1097677001966	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1097677001967	Peptidase family M23; Region: Peptidase_M23; pfam01551
1097677001968	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1097677001969	NlpC/P60 family; Region: NLPC_P60; cl17555
1097677001970	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1097677001971	dimer interface [polypeptide binding]; other site
1097677001972	substrate binding site [chemical binding]; other site
1097677001973	metal binding sites [ion binding]; metal-binding site
1097677001974	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1097677001975	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1097677001976	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1097677001977	active site
1097677001978	FtsH Extracellular; Region: FtsH_ext; pfam06480
1097677001979	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1097677001980	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097677001981	Walker A motif; other site
1097677001982	ATP binding site [chemical binding]; other site
1097677001983	Walker B motif; other site
1097677001984	arginine finger; other site
1097677001985	Peptidase family M41; Region: Peptidase_M41; pfam01434
1097677001986	GTP cyclohydrolase I; Provisional; Region: PLN03044
1097677001987	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
1097677001988	active site
1097677001989	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1097677001990	dihydropteroate synthase; Region: DHPS; TIGR01496
1097677001991	substrate binding pocket [chemical binding]; other site
1097677001992	dimer interface [polypeptide binding]; other site
1097677001993	inhibitor binding site; inhibition site
1097677001994	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1097677001995	homooctamer interface [polypeptide binding]; other site
1097677001996	active site
1097677001997	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1097677001998	catalytic center binding site [active]
1097677001999	ATP binding site [chemical binding]; other site
1097677002000	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
1097677002001	Bacterial PH domain; Region: DUF304; cl01348
1097677002002	Predicted membrane protein [Function unknown]; Region: COG3428
1097677002003	Bacterial PH domain; Region: DUF304; pfam03703
1097677002004	Bacterial PH domain; Region: DUF304; pfam03703
1097677002005	Rossmann-like domain; Region: Rossmann-like; pfam10727
1097677002006	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
1097677002007	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1097677002008	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1097677002009	active site
1097677002010	ATP-binding site [chemical binding]; other site
1097677002011	pantoate-binding site; other site
1097677002012	HXXH motif; other site
1097677002013	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1097677002014	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1097677002015	dimer interface [polypeptide binding]; other site
1097677002016	putative anticodon binding site; other site
1097677002017	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1097677002018	motif 1; other site
1097677002019	dimer interface [polypeptide binding]; other site
1097677002020	active site
1097677002021	motif 2; other site
1097677002022	motif 3; other site
1097677002023	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1097677002024	Clp amino terminal domain; Region: Clp_N; pfam02861
1097677002025	Clp amino terminal domain; Region: Clp_N; pfam02861
1097677002026	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097677002027	Walker A motif; other site
1097677002028	ATP binding site [chemical binding]; other site
1097677002029	Walker B motif; other site
1097677002030	arginine finger; other site
1097677002031	UvrB/uvrC motif; Region: UVR; pfam02151
1097677002032	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097677002033	Walker A motif; other site
1097677002034	ATP binding site [chemical binding]; other site
1097677002035	Walker B motif; other site
1097677002036	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1097677002037	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097677002038	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677002039	NAD(P) binding site [chemical binding]; other site
1097677002040	active site
1097677002041	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097677002042	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097677002043	active site
1097677002044	catalytic tetrad [active]
1097677002045	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1097677002046	23S rRNA interface [nucleotide binding]; other site
1097677002047	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1097677002048	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1097677002049	core dimer interface [polypeptide binding]; other site
1097677002050	peripheral dimer interface [polypeptide binding]; other site
1097677002051	L10 interface [polypeptide binding]; other site
1097677002052	L11 interface [polypeptide binding]; other site
1097677002053	putative EF-Tu interaction site [polypeptide binding]; other site
1097677002054	putative EF-G interaction site [polypeptide binding]; other site
1097677002055	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097677002056	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097677002057	DNA binding residues [nucleotide binding]
1097677002058	dimerization interface [polypeptide binding]; other site
1097677002059	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1097677002060	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677002061	putative substrate translocation pore; other site
1097677002062	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097677002063	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097677002064	DNA binding site [nucleotide binding]
1097677002065	domain linker motif; other site
1097677002066	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1097677002067	dimerization interface [polypeptide binding]; other site
1097677002068	ligand binding site [chemical binding]; other site
1097677002069	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1097677002070	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1097677002071	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097677002072	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677002073	dimer interface [polypeptide binding]; other site
1097677002074	conserved gate region; other site
1097677002075	putative PBP binding loops; other site
1097677002076	ABC-ATPase subunit interface; other site
1097677002077	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097677002078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677002079	dimer interface [polypeptide binding]; other site
1097677002080	conserved gate region; other site
1097677002081	putative PBP binding loops; other site
1097677002082	ABC-ATPase subunit interface; other site
1097677002083	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1097677002084	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1097677002085	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
1097677002086	Walker A/P-loop; other site
1097677002087	ATP binding site [chemical binding]; other site
1097677002088	Q-loop/lid; other site
1097677002089	ABC transporter signature motif; other site
1097677002090	Walker B; other site
1097677002091	D-loop; other site
1097677002092	H-loop/switch region; other site
1097677002093	Domain of unknown function (DUF305); Region: DUF305; pfam03713
1097677002094	Protein of unknown function (DUF3105); Region: DUF3105; pfam11303
1097677002095	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
1097677002096	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1097677002097	dimer interface [polypeptide binding]; other site
1097677002098	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677002099	catalytic residue [active]
1097677002100	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
1097677002101	cystathionine gamma-synthase; Provisional; Region: PRK07811
1097677002102	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1097677002103	homodimer interface [polypeptide binding]; other site
1097677002104	substrate-cofactor binding pocket; other site
1097677002105	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677002106	catalytic residue [active]
1097677002107	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1097677002108	RNA/DNA hybrid binding site [nucleotide binding]; other site
1097677002109	active site
1097677002110	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1097677002111	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097677002112	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097677002113	DNA binding site [nucleotide binding]
1097677002114	domain linker motif; other site
1097677002115	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
1097677002116	ligand binding site [chemical binding]; other site
1097677002117	dimerization interface (open form) [polypeptide binding]; other site
1097677002118	dimerization interface (closed form) [polypeptide binding]; other site
1097677002119	ribulokinase; Provisional; Region: PRK04123
1097677002120	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
1097677002121	N- and C-terminal domain interface [polypeptide binding]; other site
1097677002122	active site
1097677002123	MgATP binding site [chemical binding]; other site
1097677002124	catalytic site [active]
1097677002125	metal binding site [ion binding]; metal-binding site
1097677002126	carbohydrate binding site [chemical binding]; other site
1097677002127	homodimer interface [polypeptide binding]; other site
1097677002128	L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557
1097677002129	intersubunit interface [polypeptide binding]; other site
1097677002130	active site
1097677002131	Zn2+ binding site [ion binding]; other site
1097677002132	L-arabinose isomerase; Provisional; Region: PRK02929
1097677002133	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
1097677002134	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1097677002135	trimer interface [polypeptide binding]; other site
1097677002136	substrate binding site [chemical binding]; other site
1097677002137	Mn binding site [ion binding]; other site
1097677002138	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
1097677002139	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1097677002140	putative ligand binding site [chemical binding]; other site
1097677002141	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
1097677002142	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097677002143	Walker A/P-loop; other site
1097677002144	ATP binding site [chemical binding]; other site
1097677002145	Q-loop/lid; other site
1097677002146	ABC transporter signature motif; other site
1097677002147	Walker B; other site
1097677002148	D-loop; other site
1097677002149	H-loop/switch region; other site
1097677002150	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1097677002151	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097677002152	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097677002153	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097677002154	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097677002155	TM-ABC transporter signature motif; other site
1097677002156	xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631
1097677002157	xylose isomerase; Provisional; Region: PRK12677
1097677002158	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1097677002159	beta-galactosidase; Region: BGL; TIGR03356
1097677002160	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1097677002161	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1097677002162	MarR family; Region: MarR_2; cl17246
1097677002163	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097677002164	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097677002165	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097677002166	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
1097677002167	putative dimerization interface [polypeptide binding]; other site
1097677002168	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1097677002169	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097677002170	catalytic residue [active]
1097677002171	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677002172	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1097677002173	putative substrate translocation pore; other site
1097677002174	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
1097677002175	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097677002176	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097677002177	DNA binding residues [nucleotide binding]
1097677002178	dimerization interface [polypeptide binding]; other site
1097677002179	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1097677002180	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1097677002181	NAD(P) binding site [chemical binding]; other site
1097677002182	putative active site [active]
1097677002183	phosphate acetyltransferase; Reviewed; Region: PRK05632
1097677002184	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1097677002185	DRTGG domain; Region: DRTGG; pfam07085
1097677002186	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1097677002187	propionate/acetate kinase; Provisional; Region: PRK12379
1097677002188	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1097677002189	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
1097677002190	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
1097677002191	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097677002192	Walker A motif; other site
1097677002193	ATP binding site [chemical binding]; other site
1097677002194	Walker B motif; other site
1097677002195	arginine finger; other site
1097677002196	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1097677002197	recombination protein RecR; Reviewed; Region: recR; PRK00076
1097677002198	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1097677002199	RecR protein; Region: RecR; pfam02132
1097677002200	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1097677002201	putative active site [active]
1097677002202	putative metal-binding site [ion binding]; other site
1097677002203	tetramer interface [polypeptide binding]; other site
1097677002204	aspartate kinase; Reviewed; Region: PRK06635
1097677002205	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1097677002206	putative nucleotide binding site [chemical binding]; other site
1097677002207	putative catalytic residues [active]
1097677002208	putative Mg ion binding site [ion binding]; other site
1097677002209	putative aspartate binding site [chemical binding]; other site
1097677002210	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1097677002211	putative allosteric regulatory site; other site
1097677002212	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1097677002213	putative allosteric regulatory residue; other site
1097677002214	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1097677002215	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1097677002216	malate:quinone oxidoreductase; Validated; Region: PRK05257
1097677002217	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1097677002218	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097677002219	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1097677002220	FeS/SAM binding site; other site
1097677002221	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
1097677002222	DNA binding residues [nucleotide binding]
1097677002223	dimerization interface [polypeptide binding]; other site
1097677002224	thymidine kinase; Provisional; Region: PRK04296
1097677002225	TIGR04140 family protein; Region: chp_AF_0576
1097677002226	Chain length determinant protein; Region: Wzz; cl15801
1097677002227	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1097677002228	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097677002229	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
1097677002230	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1097677002231	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1097677002232	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1097677002233	Transglycosylase; Region: Transgly; pfam00912
1097677002234	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1097677002235	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1097677002236	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1097677002237	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1097677002238	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1097677002239	putative active site [active]
1097677002240	putative metal binding site [ion binding]; other site
1097677002241	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1097677002242	Transglycosylase; Region: Transgly; pfam00912
1097677002243	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1097677002244	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1097677002245	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1097677002246	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
1097677002247	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1097677002248	homotrimer interaction site [polypeptide binding]; other site
1097677002249	putative active site [active]
1097677002250	acetyl-CoA synthetase; Provisional; Region: PRK00174
1097677002251	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1097677002252	active site
1097677002253	CoA binding site [chemical binding]; other site
1097677002254	acyl-activating enzyme (AAE) consensus motif; other site
1097677002255	AMP binding site [chemical binding]; other site
1097677002256	acetate binding site [chemical binding]; other site
1097677002257	Type II/IV secretion system protein; Region: T2SE; pfam00437
1097677002258	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1097677002259	ATP binding site [chemical binding]; other site
1097677002260	Walker A motif; other site
1097677002261	hexamer interface [polypeptide binding]; other site
1097677002262	Walker B motif; other site
1097677002263	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
1097677002264	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1097677002265	DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051
1097677002266	active site
1097677002267	interdomain interaction site; other site
1097677002268	putative metal-binding site [ion binding]; other site
1097677002269	nucleotide binding site [chemical binding]; other site
1097677002270	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1097677002271	domain I; other site
1097677002272	DNA binding groove [nucleotide binding]
1097677002273	phosphate binding site [ion binding]; other site
1097677002274	domain II; other site
1097677002275	domain III; other site
1097677002276	nucleotide binding site [chemical binding]; other site
1097677002277	catalytic site [active]
1097677002278	domain IV; other site
1097677002279	Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754
1097677002280	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1097677002281	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1097677002282	thymidylate kinase; Validated; Region: tmk; PRK00698
1097677002283	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1097677002284	TMP-binding site; other site
1097677002285	ATP-binding site [chemical binding]; other site
1097677002286	DNA polymerase III subunit delta'; Validated; Region: PRK07940
1097677002287	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1097677002288	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1097677002289	TAP-like protein; Region: Abhydrolase_4; pfam08386
1097677002290	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
1097677002291	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1097677002292	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1097677002293	catalytic triad [active]
1097677002294	conserved cis-peptide bond; other site
1097677002295	succinic semialdehyde dehydrogenase; Region: PLN02278
1097677002296	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1097677002297	tetramerization interface [polypeptide binding]; other site
1097677002298	NAD(P) binding site [chemical binding]; other site
1097677002299	catalytic residues [active]
1097677002300	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1097677002301	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1097677002302	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
1097677002303	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1097677002304	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677002305	Walker A/P-loop; other site
1097677002306	ATP binding site [chemical binding]; other site
1097677002307	ABC transporter; Region: ABC_tran; pfam00005
1097677002308	Q-loop/lid; other site
1097677002309	ABC transporter signature motif; other site
1097677002310	Walker B; other site
1097677002311	D-loop; other site
1097677002312	H-loop/switch region; other site
1097677002313	nodulation ABC transporter NodI; Provisional; Region: PRK13537
1097677002314	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677002315	Walker A/P-loop; other site
1097677002316	ATP binding site [chemical binding]; other site
1097677002317	Q-loop/lid; other site
1097677002318	ABC transporter signature motif; other site
1097677002319	Walker B; other site
1097677002320	D-loop; other site
1097677002321	H-loop/switch region; other site
1097677002322	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1097677002323	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1097677002324	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1097677002325	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1097677002326	Cmm ortholog CMM_0941; Cms ortholog CMS_0200
1097677002327	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1097677002328	substrate binding site [chemical binding]; other site
1097677002329	ATP binding site [chemical binding]; other site
1097677002330	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1097677002331	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097677002332	non-specific DNA binding site [nucleotide binding]; other site
1097677002333	salt bridge; other site
1097677002334	sequence-specific DNA binding site [nucleotide binding]; other site
1097677002335	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1097677002336	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1097677002337	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
1097677002338	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097677002339	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677002340	dimer interface [polypeptide binding]; other site
1097677002341	conserved gate region; other site
1097677002342	putative PBP binding loops; other site
1097677002343	ABC-ATPase subunit interface; other site
1097677002344	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1097677002345	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1097677002346	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
1097677002347	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097677002348	DNA binding site [nucleotide binding]
1097677002349	domain linker motif; other site
1097677002350	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1097677002351	dimerization interface [polypeptide binding]; other site
1097677002352	ligand binding site [chemical binding]; other site
1097677002353	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1097677002354	MOSC domain; Region: MOSC; pfam03473
1097677002355	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097677002356	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677002357	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097677002358	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677002359	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1097677002360	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1097677002361	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1097677002362	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1097677002363	multidrug resistance protein MdtH; Provisional; Region: PRK11646
1097677002364	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1097677002365	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097677002366	Walker A/P-loop; other site
1097677002367	ATP binding site [chemical binding]; other site
1097677002368	Q-loop/lid; other site
1097677002369	ABC transporter signature motif; other site
1097677002370	Walker B; other site
1097677002371	D-loop; other site
1097677002372	H-loop/switch region; other site
1097677002373	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097677002374	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1097677002375	Walker A/P-loop; other site
1097677002376	ATP binding site [chemical binding]; other site
1097677002377	Q-loop/lid; other site
1097677002378	ABC transporter signature motif; other site
1097677002379	Walker B; other site
1097677002380	D-loop; other site
1097677002381	H-loop/switch region; other site
1097677002382	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1097677002383	homopentamer interface [polypeptide binding]; other site
1097677002384	active site
1097677002385	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1097677002386	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1097677002387	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1097677002388	dimerization interface [polypeptide binding]; other site
1097677002389	active site
1097677002390	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1097677002391	Lumazine binding domain; Region: Lum_binding; pfam00677
1097677002392	Lumazine binding domain; Region: Lum_binding; pfam00677
1097677002393	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1097677002394	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1097677002395	catalytic motif [active]
1097677002396	Zn binding site [ion binding]; other site
1097677002397	RibD C-terminal domain; Region: RibD_C; cl17279
1097677002398	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1097677002399	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097677002400	motif II; other site
1097677002401	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1097677002402	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1097677002403	active site
1097677002404	HIGH motif; other site
1097677002405	dimer interface [polypeptide binding]; other site
1097677002406	KMSKS motif; other site
1097677002407	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
1097677002408	putative active site [active]
1097677002409	putative catalytic site [active]
1097677002410	putative DNA binding site [nucleotide binding]; other site
1097677002411	putative phosphate binding site [ion binding]; other site
1097677002412	metal binding site A [ion binding]; metal-binding site
1097677002413	putative AP binding site [nucleotide binding]; other site
1097677002414	putative metal binding site B [ion binding]; other site
1097677002415	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
1097677002416	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1097677002417	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1097677002418	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1097677002419	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1097677002420	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1097677002421	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097677002422	catalytic loop [active]
1097677002423	iron binding site [ion binding]; other site
1097677002424	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
1097677002425	L-aspartate oxidase; Provisional; Region: PRK06175
1097677002426	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1097677002427	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
1097677002428	putative Iron-sulfur protein interface [polypeptide binding]; other site
1097677002429	putative proximal heme binding site [chemical binding]; other site
1097677002430	putative SdhC-like subunit interface [polypeptide binding]; other site
1097677002431	putative distal heme binding site [chemical binding]; other site
1097677002432	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
1097677002433	putative Iron-sulfur protein interface [polypeptide binding]; other site
1097677002434	putative proximal heme binding site [chemical binding]; other site
1097677002435	putative SdhD-like interface [polypeptide binding]; other site
1097677002436	putative distal heme binding site [chemical binding]; other site
1097677002437	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097677002438	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1097677002439	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
1097677002440	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1097677002441	Substrate binding site; other site
1097677002442	Cupin domain; Region: Cupin_2; cl17218
1097677002443	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1097677002444	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1097677002445	ligand binding site [chemical binding]; other site
1097677002446	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1097677002447	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1097677002448	ligand binding site [chemical binding]; other site
1097677002449	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1097677002450	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097677002451	Walker A/P-loop; other site
1097677002452	ATP binding site [chemical binding]; other site
1097677002453	Q-loop/lid; other site
1097677002454	ABC transporter signature motif; other site
1097677002455	Walker B; other site
1097677002456	D-loop; other site
1097677002457	H-loop/switch region; other site
1097677002458	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1097677002459	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097677002460	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1097677002461	TM-ABC transporter signature motif; other site
1097677002462	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097677002463	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1097677002464	TM-ABC transporter signature motif; other site
1097677002465	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1097677002466	active site
1097677002467	catalytic motif [active]
1097677002468	Zn binding site [ion binding]; other site
1097677002469	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
1097677002470	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1097677002471	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1097677002472	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
1097677002473	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1097677002474	active site
1097677002475	tetramer interface [polypeptide binding]; other site
1097677002476	adenosine deaminase; Provisional; Region: PRK09358
1097677002477	active site
1097677002478	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1097677002479	active site
1097677002480	phosphorylation site [posttranslational modification]
1097677002481	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1097677002482	active site
1097677002483	P-loop; other site
1097677002484	phosphorylation site [posttranslational modification]
1097677002485	Cmm ortholog CMM_0986; Cms ortholog CMS_0604
1097677002486	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1097677002487	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1097677002488	DNA binding residues [nucleotide binding]
1097677002489	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1097677002490	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1097677002491	active site
1097677002492	substrate binding site [chemical binding]; other site
1097677002493	metal binding site [ion binding]; metal-binding site
1097677002494	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1097677002495	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
1097677002496	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097677002497	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097677002498	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1097677002499	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1097677002500	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1097677002501	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1097677002502	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1097677002503	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1097677002504	carboxyltransferase (CT) interaction site; other site
1097677002505	biotinylation site [posttranslational modification]; other site
1097677002506	Maf-like protein; Region: Maf; pfam02545
1097677002507	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1097677002508	active site
1097677002509	dimer interface [polypeptide binding]; other site
1097677002510	TRAM domain; Region: TRAM; pfam01938
1097677002511	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1097677002512	transcriptional regulator NarP; Provisional; Region: PRK10403
1097677002513	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677002514	active site
1097677002515	phosphorylation site [posttranslational modification]
1097677002516	intermolecular recognition site; other site
1097677002517	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1097677002518	DNA binding residues [nucleotide binding]
1097677002519	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097677002520	ATP binding site [chemical binding]; other site
1097677002521	Mg2+ binding site [ion binding]; other site
1097677002522	G-X-G motif; other site
1097677002523	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1097677002524	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1097677002525	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1097677002526	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1097677002527	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1097677002528	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1097677002529	Bacterial PH domain; Region: DUF304; pfam03703
1097677002530	Predicted membrane protein [Function unknown]; Region: COG2246
1097677002531	GtrA-like protein; Region: GtrA; pfam04138
1097677002532	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1097677002533	ATP-grasp domain; Region: ATP-grasp; pfam02222
1097677002534	AIR carboxylase; Region: AIRC; pfam00731
1097677002535	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1097677002536	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1097677002537	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097677002538	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1097677002539	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1097677002540	Walker A/P-loop; other site
1097677002541	ATP binding site [chemical binding]; other site
1097677002542	Q-loop/lid; other site
1097677002543	ABC transporter signature motif; other site
1097677002544	Walker B; other site
1097677002545	D-loop; other site
1097677002546	H-loop/switch region; other site
1097677002547	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1097677002548	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1097677002549	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1097677002550	NADP binding site [chemical binding]; other site
1097677002551	active site
1097677002552	putative substrate binding site [chemical binding]; other site
1097677002553	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1097677002554	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1097677002555	NAD binding site [chemical binding]; other site
1097677002556	substrate binding site [chemical binding]; other site
1097677002557	homodimer interface [polypeptide binding]; other site
1097677002558	active site
1097677002559	GtrA-like protein; Region: GtrA; pfam04138
1097677002560	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
1097677002561	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1097677002562	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1097677002563	substrate binding site; other site
1097677002564	tetramer interface; other site
1097677002565	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1097677002566	extended (e) SDRs; Region: SDR_e; cd08946
1097677002567	substrate binding site [chemical binding]; other site
1097677002568	active site
1097677002569	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1097677002570	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097677002571	active site
1097677002572	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1097677002573	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1097677002574	active site
1097677002575	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1097677002576	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097677002577	active site
1097677002578	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097677002579	active site
1097677002580	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1097677002581	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1097677002582	UDP-galactopyranose mutase; Region: GLF; pfam03275
1097677002583	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1097677002584	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097677002585	active site
1097677002586	Predicted membrane protein [Function unknown]; Region: COG2246
1097677002587	GtrA-like protein; Region: GtrA; pfam04138
1097677002588	O-Antigen ligase; Region: Wzy_C; pfam04932
1097677002589	acyl-coenzyme A oxidase; Region: PLN02526
1097677002590	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097677002591	active site
1097677002592	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
1097677002593	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1097677002594	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1097677002595	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1097677002596	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677002597	NAD(P) binding site [chemical binding]; other site
1097677002598	active site
1097677002599	Transcription factor WhiB; Region: Whib; pfam02467
1097677002600	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1097677002601	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097677002602	active site
1097677002603	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
1097677002604	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
1097677002605	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1097677002606	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
1097677002607	active site
1097677002608	substrate binding site [chemical binding]; other site
1097677002609	metal binding site [ion binding]; metal-binding site
1097677002610	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
1097677002611	putative homodimer interface [polypeptide binding]; other site
1097677002612	putative homotetramer interface [polypeptide binding]; other site
1097677002613	putative allosteric switch controlling residues; other site
1097677002614	putative metal binding site [ion binding]; other site
1097677002615	putative homodimer-homodimer interface [polypeptide binding]; other site
1097677002616	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1097677002617	metal-binding site [ion binding]
1097677002618	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1097677002619	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1097677002620	metal-binding site [ion binding]
1097677002621	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1097677002622	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1097677002623	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1097677002624	Adenosylhomocysteinase; Provisional; Region: PTZ00075
1097677002625	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1097677002626	homotetramer interface [polypeptide binding]; other site
1097677002627	ligand binding site [chemical binding]; other site
1097677002628	catalytic site [active]
1097677002629	NAD binding site [chemical binding]; other site
1097677002630	RDD family; Region: RDD; pfam06271
1097677002631	Integral membrane protein DUF95; Region: DUF95; pfam01944
1097677002632	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1097677002633	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1097677002634	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1097677002635	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1097677002636	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677002637	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097677002638	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677002639	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1097677002640	Protein of unknown function DUF58; Region: DUF58; pfam01882
1097677002641	MoxR-like ATPases [General function prediction only]; Region: COG0714
1097677002642	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097677002643	Walker A motif; other site
1097677002644	ATP binding site [chemical binding]; other site
1097677002645	Walker B motif; other site
1097677002646	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
1097677002647	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
1097677002648	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097677002649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677002650	active site
1097677002651	phosphorylation site [posttranslational modification]
1097677002652	intermolecular recognition site; other site
1097677002653	dimerization interface [polypeptide binding]; other site
1097677002654	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097677002655	DNA binding site [nucleotide binding]
1097677002656	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1097677002657	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1097677002658	dimerization interface [polypeptide binding]; other site
1097677002659	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097677002660	dimer interface [polypeptide binding]; other site
1097677002661	phosphorylation site [posttranslational modification]
1097677002662	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097677002663	ATP binding site [chemical binding]; other site
1097677002664	Mg2+ binding site [ion binding]; other site
1097677002665	G-X-G motif; other site
1097677002666	lipoprotein LpqB; Provisional; Region: PRK13615
1097677002667	Sporulation and spore germination; Region: Germane; pfam10646
1097677002668	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1097677002669	active site
1097677002670	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1097677002671	30S subunit binding site; other site
1097677002672	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1097677002673	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1097677002674	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1097677002675	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1097677002676	nucleotide binding region [chemical binding]; other site
1097677002677	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
1097677002678	PAS fold; Region: PAS_4; pfam08448
1097677002679	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1097677002680	Histidine kinase; Region: HisKA_2; pfam07568
1097677002681	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097677002682	ATP binding site [chemical binding]; other site
1097677002683	Mg2+ binding site [ion binding]; other site
1097677002684	G-X-G motif; other site
1097677002685	Transcription factor WhiB; Region: Whib; pfam02467
1097677002686	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1097677002687	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1097677002688	catalytic triad [active]
1097677002689	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
1097677002690	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1097677002691	L-asparagine permease; Provisional; Region: PRK15049
1097677002692	H+ Antiporter protein; Region: 2A0121; TIGR00900
1097677002693	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677002694	putative substrate translocation pore; other site
1097677002695	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097677002696	MarR family; Region: MarR_2; pfam12802
1097677002697	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
1097677002698	TAP-like protein; Region: Abhydrolase_4; pfam08386
1097677002699	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1097677002700	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1097677002701	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
1097677002702	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1097677002703	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1097677002704	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1097677002705	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1097677002706	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1097677002707	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1097677002708	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1097677002709	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097677002710	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677002711	MMPL family; Region: MMPL; pfam03176
1097677002712	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
1097677002713	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1097677002714	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1097677002715	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
1097677002716	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1097677002717	Fructosamine kinase; Region: Fructosamin_kin; cl17579
1097677002718	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1097677002719	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
1097677002720	active site
1097677002721	homotetramer interface [polypeptide binding]; other site
1097677002722	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
1097677002723	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
1097677002724	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
1097677002725	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1097677002726	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
1097677002727	Cmm ortholog CMM_1087; Cms ortholog CMS_1407
1097677002728	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1097677002729	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
1097677002730	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
1097677002731	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
1097677002732	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1097677002733	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
1097677002734	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
1097677002735	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
1097677002736	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1097677002737	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
1097677002738	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1097677002739	PYR/PP interface [polypeptide binding]; other site
1097677002740	dimer interface [polypeptide binding]; other site
1097677002741	TPP binding site [chemical binding]; other site
1097677002742	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097677002743	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1097677002744	TPP-binding site [chemical binding]; other site
1097677002745	dimer interface [polypeptide binding]; other site
1097677002746	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1097677002747	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1097677002748	putative valine binding site [chemical binding]; other site
1097677002749	dimer interface [polypeptide binding]; other site
1097677002750	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1097677002751	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1097677002752	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1097677002753	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1097677002754	Predicted membrane protein [Function unknown]; Region: COG4270
1097677002755	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1097677002756	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1097677002757	ligand binding site [chemical binding]; other site
1097677002758	NAD binding site [chemical binding]; other site
1097677002759	dimerization interface [polypeptide binding]; other site
1097677002760	catalytic site [active]
1097677002761	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1097677002762	putative L-serine binding site [chemical binding]; other site
1097677002763	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097677002764	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677002765	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
1097677002766	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677002767	putative substrate translocation pore; other site
1097677002768	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
1097677002769	tartrate dehydrogenase; Region: TTC; TIGR02089
1097677002770	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1097677002771	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1097677002772	homodimer interface [polypeptide binding]; other site
1097677002773	substrate-cofactor binding pocket; other site
1097677002774	catalytic residue [active]
1097677002775	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
1097677002776	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1097677002777	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1097677002778	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1097677002779	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1097677002780	HIGH motif; other site
1097677002781	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1097677002782	active site
1097677002783	KMSKS motif; other site
1097677002784	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1097677002785	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1097677002786	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1097677002787	Cmm ortholog CMM_1112; Cms ortholog CMS_1432
1097677002788	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097677002789	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097677002790	active site
1097677002791	catalytic tetrad [active]
1097677002792	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1097677002793	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1097677002794	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1097677002795	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
1097677002796	proposed catalytic triad [active]
1097677002797	active site nucleophile [active]
1097677002798	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1097677002799	ligand binding site [chemical binding]; other site
1097677002800	active site
1097677002801	UGI interface [polypeptide binding]; other site
1097677002802	catalytic site [active]
1097677002803	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1097677002804	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1097677002805	CAAX protease self-immunity; Region: Abi; pfam02517
1097677002806	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677002807	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097677002808	NAD(P) binding site [chemical binding]; other site
1097677002809	active site
1097677002810	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1097677002811	active site
1097677002812	dimer interface [polypeptide binding]; other site
1097677002813	magnesium binding site [ion binding]; other site
1097677002814	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1097677002815	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
1097677002816	tetramer interface [polypeptide binding]; other site
1097677002817	active site
1097677002818	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097677002819	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097677002820	DNA binding residues [nucleotide binding]
1097677002821	dimerization interface [polypeptide binding]; other site
1097677002822	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1097677002823	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
1097677002824	putative active site [active]
1097677002825	putative metal binding site [ion binding]; other site
1097677002826	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1097677002827	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1097677002828	Amidase; Region: Amidase; cl11426
1097677002829	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1097677002830	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1097677002831	FAD binding pocket [chemical binding]; other site
1097677002832	FAD binding motif [chemical binding]; other site
1097677002833	phosphate binding motif [ion binding]; other site
1097677002834	NAD binding pocket [chemical binding]; other site
1097677002835	Siderophore-interacting protein; Region: SIP; pfam04954
1097677002836	short chain dehydrogenase; Provisional; Region: PRK06197
1097677002837	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677002838	NAD(P) binding site [chemical binding]; other site
1097677002839	active site
1097677002840	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1097677002841	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097677002842	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1097677002843	enoyl-CoA hydratase; Provisional; Region: PRK06563
1097677002844	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097677002845	substrate binding site [chemical binding]; other site
1097677002846	oxyanion hole (OAH) forming residues; other site
1097677002847	trimer interface [polypeptide binding]; other site
1097677002848	Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999
1097677002849	active site
1097677002850	Mn binding site [ion binding]; other site
1097677002851	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1097677002852	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1097677002853	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1097677002854	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1097677002855	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
1097677002856	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
1097677002857	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1097677002858	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1097677002859	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1097677002860	catalytic triad [active]
1097677002861	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1097677002862	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677002863	NAD(P) binding site [chemical binding]; other site
1097677002864	active site
1097677002865	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677002866	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097677002867	NAD(P) binding site [chemical binding]; other site
1097677002868	active site
1097677002869	benzoate transport; Region: 2A0115; TIGR00895
1097677002870	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677002871	putative substrate translocation pore; other site
1097677002872	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
1097677002873	active site
1097677002874	catalytic site [active]
1097677002875	Zn binding site [ion binding]; other site
1097677002876	tetramer interface [polypeptide binding]; other site
1097677002877	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1097677002878	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1097677002879	active site
1097677002880	homotetramer interface [polypeptide binding]; other site
1097677002881	homodimer interface [polypeptide binding]; other site
1097677002882	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097677002883	DNA binding site [nucleotide binding]
1097677002884	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097677002885	domain linker motif; other site
1097677002886	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285
1097677002887	putative dimerization interface [polypeptide binding]; other site
1097677002888	putative ligand binding site [chemical binding]; other site
1097677002889	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1097677002890	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1097677002891	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1097677002892	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1097677002893	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1097677002894	active site
1097677002895	HIGH motif; other site
1097677002896	KMSK motif region; other site
1097677002897	tRNA binding surface [nucleotide binding]; other site
1097677002898	DALR anticodon binding domain; Region: DALR_1; smart00836
1097677002899	anticodon binding site; other site
1097677002900	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1097677002901	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1097677002902	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1097677002903	active site
1097677002904	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1097677002905	substrate binding site [chemical binding]; other site
1097677002906	catalytic residues [active]
1097677002907	dimer interface [polypeptide binding]; other site
1097677002908	homoserine dehydrogenase; Provisional; Region: PRK06349
1097677002909	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1097677002910	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1097677002911	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1097677002912	threonine synthase; Reviewed; Region: PRK06721
1097677002913	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1097677002914	homodimer interface [polypeptide binding]; other site
1097677002915	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677002916	catalytic residue [active]
1097677002917	homoserine kinase; Provisional; Region: PRK01212
1097677002918	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1097677002919	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1097677002920	transcription termination factor Rho; Provisional; Region: PRK12608
1097677002921	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1097677002922	RNA binding site [nucleotide binding]; other site
1097677002923	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1097677002924	multimer interface [polypeptide binding]; other site
1097677002925	Walker A motif; other site
1097677002926	ATP binding site [chemical binding]; other site
1097677002927	Walker B motif; other site
1097677002928	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1097677002929	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1097677002930	RF-1 domain; Region: RF-1; pfam00472
1097677002931	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1097677002932	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097677002933	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1097677002934	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097677002935	motif II; other site
1097677002936	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1097677002937	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1097677002938	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1097677002939	Mg++ binding site [ion binding]; other site
1097677002940	putative catalytic motif [active]
1097677002941	substrate binding site [chemical binding]; other site
1097677002942	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1097677002943	ATP synthase subunit C; Region: ATP-synt_C; cl00466
1097677002944	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1097677002945	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
1097677002946	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1097677002947	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1097677002948	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1097677002949	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1097677002950	beta subunit interaction interface [polypeptide binding]; other site
1097677002951	Walker A motif; other site
1097677002952	ATP binding site [chemical binding]; other site
1097677002953	Walker B motif; other site
1097677002954	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1097677002955	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1097677002956	core domain interface [polypeptide binding]; other site
1097677002957	delta subunit interface [polypeptide binding]; other site
1097677002958	epsilon subunit interface [polypeptide binding]; other site
1097677002959	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1097677002960	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1097677002961	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1097677002962	alpha subunit interaction interface [polypeptide binding]; other site
1097677002963	Walker A motif; other site
1097677002964	ATP binding site [chemical binding]; other site
1097677002965	Walker B motif; other site
1097677002966	inhibitor binding site; inhibition site
1097677002967	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1097677002968	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1097677002969	gamma subunit interface [polypeptide binding]; other site
1097677002970	epsilon subunit interface [polypeptide binding]; other site
1097677002971	LBP interface [polypeptide binding]; other site
1097677002972	hypothetical protein; Validated; Region: PRK02101
1097677002973	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1097677002974	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1097677002975	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
1097677002976	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1097677002977	DNA binding site [nucleotide binding]
1097677002978	active site
1097677002979	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1097677002980	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097677002981	putative DNA binding site [nucleotide binding]; other site
1097677002982	putative Zn2+ binding site [ion binding]; other site
1097677002983	AsnC family; Region: AsnC_trans_reg; pfam01037
1097677002984	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1097677002985	active site
1097677002986	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
1097677002987	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
1097677002988	putative trimer interface [polypeptide binding]; other site
1097677002989	putative CoA binding site [chemical binding]; other site
1097677002990	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
1097677002991	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
1097677002992	metal binding site [ion binding]; metal-binding site
1097677002993	putative dimer interface [polypeptide binding]; other site
1097677002994	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
1097677002995	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1097677002996	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097677002997	S-adenosylmethionine binding site [chemical binding]; other site
1097677002998	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1097677002999	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097677003000	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097677003001	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
1097677003002	putative dimerization interface [polypeptide binding]; other site
1097677003003	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1097677003004	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1097677003005	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097677003006	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
1097677003007	MgtE intracellular N domain; Region: MgtE_N; smart00924
1097677003008	FOG: CBS domain [General function prediction only]; Region: COG0517
1097677003009	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1097677003010	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
1097677003011	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1097677003012	active site
1097677003013	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1097677003014	putative catalytic site [active]
1097677003015	putative phosphate binding site [ion binding]; other site
1097677003016	putative metal binding site [ion binding]; other site
1097677003017	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1097677003018	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1097677003019	active site
1097677003020	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1097677003021	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
1097677003022	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1097677003023	ATP binding site [chemical binding]; other site
1097677003024	Mg++ binding site [ion binding]; other site
1097677003025	motif III; other site
1097677003026	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097677003027	nucleotide binding region [chemical binding]; other site
1097677003028	ATP-binding site [chemical binding]; other site
1097677003029	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794
1097677003030	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
1097677003031	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
1097677003032	Part of AAA domain; Region: AAA_19; pfam13245
1097677003033	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1097677003034	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1097677003035	Part of AAA domain; Region: AAA_19; pfam13245
1097677003036	Family description; Region: UvrD_C_2; pfam13538
1097677003037	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1097677003038	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1097677003039	active site
1097677003040	ATP binding site [chemical binding]; other site
1097677003041	Phosphotransferase enzyme family; Region: APH; pfam01636
1097677003042	substrate binding site [chemical binding]; other site
1097677003043	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
1097677003044	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1097677003045	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1097677003046	putative NADH binding site [chemical binding]; other site
1097677003047	putative active site [active]
1097677003048	nudix motif; other site
1097677003049	putative metal binding site [ion binding]; other site
1097677003050	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1097677003051	Part of AAA domain; Region: AAA_19; pfam13245
1097677003052	Family description; Region: UvrD_C_2; pfam13538
1097677003053	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
1097677003054	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
1097677003055	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1097677003056	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1097677003057	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1097677003058	Uncharacterized conserved protein [Function unknown]; Region: COG1615
1097677003059	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
1097677003060	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
1097677003061	putative catalytic residues [active]
1097677003062	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1097677003063	ABC1 family; Region: ABC1; cl17513
1097677003064	Predicted transcriptional regulators [Transcription]; Region: COG1695
1097677003065	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1097677003066	lipoyl synthase; Provisional; Region: PRK05481
1097677003067	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097677003068	FeS/SAM binding site; other site
1097677003069	lipoate-protein ligase B; Provisional; Region: PRK14345
1097677003070	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1097677003071	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1097677003072	FAD binding pocket [chemical binding]; other site
1097677003073	FAD binding motif [chemical binding]; other site
1097677003074	phosphate binding motif [ion binding]; other site
1097677003075	NAD binding pocket [chemical binding]; other site
1097677003076	PA14 domain; Region: PA14; pfam07691
1097677003077	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
1097677003078	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1097677003079	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1097677003080	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1097677003081	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1097677003082	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1097677003083	Domain of unknown function (DUF303); Region: DUF303; pfam03629
1097677003084	Cation efflux family; Region: Cation_efflux; cl00316
1097677003085	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097677003086	dimerization interface [polypeptide binding]; other site
1097677003087	putative DNA binding site [nucleotide binding]; other site
1097677003088	putative Zn2+ binding site [ion binding]; other site
1097677003089	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1097677003090	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1097677003091	active site
1097677003092	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677003093	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1097677003094	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1097677003095	substrate binding pocket [chemical binding]; other site
1097677003096	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1097677003097	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1097677003098	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1097677003099	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1097677003100	ATP binding site [chemical binding]; other site
1097677003101	Mg++ binding site [ion binding]; other site
1097677003102	motif III; other site
1097677003103	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097677003104	nucleotide binding region [chemical binding]; other site
1097677003105	ATP-binding site [chemical binding]; other site
1097677003106	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
1097677003107	putative RNA binding site [nucleotide binding]; other site
1097677003108	Methyltransferase domain; Region: Methyltransf_12; pfam08242
1097677003109	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1097677003110	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097677003111	non-specific DNA binding site [nucleotide binding]; other site
1097677003112	salt bridge; other site
1097677003113	sequence-specific DNA binding site [nucleotide binding]; other site
1097677003114	Cupin domain; Region: Cupin_2; pfam07883
1097677003115	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1097677003117	putative hydrolase; Provisional; Region: PRK11460
1097677003118	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1097677003119	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097677003120	Zn binding site [ion binding]; other site
1097677003121	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1097677003122	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097677003123	Zn binding site [ion binding]; other site
1097677003124	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1097677003125	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
1097677003126	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1097677003127	NAD(P) binding site [chemical binding]; other site
1097677003128	active site
1097677003129	Predicted membrane protein [Function unknown]; Region: COG2311
1097677003130	Protein of unknown function (DUF418); Region: DUF418; cl12135
1097677003131	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1097677003132	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1097677003133	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1097677003134	Walker A/P-loop; other site
1097677003135	ATP binding site [chemical binding]; other site
1097677003136	Q-loop/lid; other site
1097677003137	ABC transporter signature motif; other site
1097677003138	Walker B; other site
1097677003139	D-loop; other site
1097677003140	H-loop/switch region; other site
1097677003141	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1097677003142	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1097677003143	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1097677003144	Histidine kinase; Region: HisKA_3; pfam07730
1097677003145	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097677003146	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677003147	active site
1097677003148	phosphorylation site [posttranslational modification]
1097677003149	intermolecular recognition site; other site
1097677003150	dimerization interface [polypeptide binding]; other site
1097677003151	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097677003152	DNA binding residues [nucleotide binding]
1097677003153	dimerization interface [polypeptide binding]; other site
1097677003154	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
1097677003155	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1097677003156	putative ligand binding site [chemical binding]; other site
1097677003157	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
1097677003158	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097677003159	Walker A/P-loop; other site
1097677003160	ATP binding site [chemical binding]; other site
1097677003161	Q-loop/lid; other site
1097677003162	ABC transporter signature motif; other site
1097677003163	Walker B; other site
1097677003164	D-loop; other site
1097677003165	H-loop/switch region; other site
1097677003166	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1097677003167	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097677003168	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097677003169	TM-ABC transporter signature motif; other site
1097677003170	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1097677003171	Catalytic site [active]
1097677003172	alternate signal-mediated exported protein, RER_14450 family; Region: exp_by_SipW_III; TIGR04089
1097677003173	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1097677003174	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097677003175	dimer interface [polypeptide binding]; other site
1097677003176	phosphorylation site [posttranslational modification]
1097677003177	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097677003178	ATP binding site [chemical binding]; other site
1097677003179	Mg2+ binding site [ion binding]; other site
1097677003180	G-X-G motif; other site
1097677003181	BCCT family transporter; Region: BCCT; pfam02028
1097677003182	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1097677003183	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1097677003184	Cmm ortholog CMM_1254; Cms ortholog CMS_1006
1097677003185	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1097677003186	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1097677003187	putative di-iron ligands [ion binding]; other site
1097677003188	Cmm ortholog CMM_1256; Cms ortholog CMS_1008
1097677003189	Cmm ortholog CMM_1257; Cms ortholog CMS_1009
1097677003190	Cmm ortholog CMM_1258; Cms ortholog CMS_1010
1097677003191	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
1097677003192	active site
1097677003193	catalytic site [active]
1097677003194	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261
1097677003195	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
1097677003196	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097677003197	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677003198	dimer interface [polypeptide binding]; other site
1097677003199	conserved gate region; other site
1097677003200	putative PBP binding loops; other site
1097677003201	ABC-ATPase subunit interface; other site
1097677003202	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097677003203	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677003204	dimer interface [polypeptide binding]; other site
1097677003205	conserved gate region; other site
1097677003206	putative PBP binding loops; other site
1097677003207	ABC-ATPase subunit interface; other site
1097677003208	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1097677003209	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1097677003210	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1097677003211	non-specific DNA interactions [nucleotide binding]; other site
1097677003212	DNA binding site [nucleotide binding]
1097677003213	sequence specific DNA binding site [nucleotide binding]; other site
1097677003214	putative cAMP binding site [chemical binding]; other site
1097677003215	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1097677003216	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1097677003217	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
1097677003218	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1097677003219	A new structural DNA glycosylase; Region: AlkD_like; cl11434
1097677003220	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097677003221	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677003222	NAD(P) binding site [chemical binding]; other site
1097677003223	active site
1097677003224	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
1097677003225	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
1097677003226	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097677003227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677003228	active site
1097677003229	phosphorylation site [posttranslational modification]
1097677003230	intermolecular recognition site; other site
1097677003231	dimerization interface [polypeptide binding]; other site
1097677003232	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097677003233	DNA binding residues [nucleotide binding]
1097677003234	dimerization interface [polypeptide binding]; other site
1097677003235	Histidine kinase; Region: HisKA_3; pfam07730
1097677003236	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1097677003237	Mg2+ binding site [ion binding]; other site
1097677003238	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1097677003239	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1097677003240	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1097677003241	Walker A/P-loop; other site
1097677003242	ATP binding site [chemical binding]; other site
1097677003243	Q-loop/lid; other site
1097677003244	ABC transporter signature motif; other site
1097677003245	Walker B; other site
1097677003246	D-loop; other site
1097677003247	H-loop/switch region; other site
1097677003248	aminotransferase; Validated; Region: PRK07777
1097677003249	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097677003250	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677003251	homodimer interface [polypeptide binding]; other site
1097677003252	catalytic residue [active]
1097677003253	Cms ortholog CMS_2118
1097677003254	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1097677003255	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1097677003256	protein binding site [polypeptide binding]; other site
1097677003257	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1097677003258	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
1097677003259	Ligand binding site; other site
1097677003260	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1097677003261	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1097677003262	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097677003263	active site
1097677003264	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1097677003265	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1097677003266	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097677003267	non-specific DNA binding site [nucleotide binding]; other site
1097677003268	salt bridge; other site
1097677003269	sequence-specific DNA binding site [nucleotide binding]; other site
1097677003270	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1097677003271	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1097677003272	Walker A/P-loop; other site
1097677003273	ATP binding site [chemical binding]; other site
1097677003274	Q-loop/lid; other site
1097677003275	ABC transporter signature motif; other site
1097677003276	Walker B; other site
1097677003277	D-loop; other site
1097677003278	H-loop/switch region; other site
1097677003279	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1097677003280	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1097677003281	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
1097677003282	active site
1097677003283	metal-binding site
1097677003284	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1097677003285	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1097677003286	Walker A/P-loop; other site
1097677003287	ATP binding site [chemical binding]; other site
1097677003288	Q-loop/lid; other site
1097677003289	ABC transporter signature motif; other site
1097677003290	Walker B; other site
1097677003291	D-loop; other site
1097677003292	H-loop/switch region; other site
1097677003293	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
1097677003294	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1097677003295	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1097677003296	active site
1097677003297	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
1097677003298	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
1097677003299	glutamate racemase; Provisional; Region: PRK00865
1097677003300	ribonuclease PH; Reviewed; Region: rph; PRK00173
1097677003301	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1097677003302	hexamer interface [polypeptide binding]; other site
1097677003303	active site
1097677003304	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1097677003305	active site
1097677003306	dimerization interface [polypeptide binding]; other site
1097677003307	Cation efflux family; Region: Cation_efflux; cl00316
1097677003308	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1097677003309	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1097677003310	Cmm ortholog; Cms ortholog CMS_2096
1097677003311	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1097677003312	D-xylulose kinase; Region: XylB; TIGR01312
1097677003313	nucleotide binding site [chemical binding]; other site
1097677003314	Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630
1097677003315	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1097677003316	ATP binding site [chemical binding]; other site
1097677003317	Walker A motif; other site
1097677003318	hexamer interface [polypeptide binding]; other site
1097677003319	Walker B motif; other site
1097677003320	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1097677003321	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
1097677003322	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1097677003323	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677003324	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097677003325	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1097677003326	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1097677003327	RF-1 domain; Region: RF-1; pfam00472
1097677003328	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1097677003329	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677003330	Walker A/P-loop; other site
1097677003331	ATP binding site [chemical binding]; other site
1097677003332	Q-loop/lid; other site
1097677003333	ABC transporter signature motif; other site
1097677003334	Walker B; other site
1097677003335	D-loop; other site
1097677003336	H-loop/switch region; other site
1097677003337	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1097677003338	FtsX-like permease family; Region: FtsX; pfam02687
1097677003339	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1097677003340	SmpB-tmRNA interface; other site
1097677003341	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1097677003342	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677003343	dimer interface [polypeptide binding]; other site
1097677003344	conserved gate region; other site
1097677003345	ABC-ATPase subunit interface; other site
1097677003346	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677003347	putative PBP binding loops; other site
1097677003348	dimer interface [polypeptide binding]; other site
1097677003349	ABC-ATPase subunit interface; other site
1097677003350	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1097677003351	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677003352	Walker A/P-loop; other site
1097677003353	ATP binding site [chemical binding]; other site
1097677003354	Q-loop/lid; other site
1097677003355	ABC transporter signature motif; other site
1097677003356	Walker B; other site
1097677003357	D-loop; other site
1097677003358	H-loop/switch region; other site
1097677003359	TOBE domain; Region: TOBE; pfam03459
1097677003360	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1097677003361	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
1097677003362	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677003363	putative substrate translocation pore; other site
1097677003364	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1097677003365	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
1097677003366	active site
1097677003367	Predicted GTPases [General function prediction only]; Region: COG1162
1097677003368	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1097677003369	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1097677003370	GTP/Mg2+ binding site [chemical binding]; other site
1097677003371	G4 box; other site
1097677003372	G5 box; other site
1097677003373	G1 box; other site
1097677003374	Switch I region; other site
1097677003375	G2 box; other site
1097677003376	G3 box; other site
1097677003377	Switch II region; other site
1097677003378	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1097677003379	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1097677003380	hinge; other site
1097677003381	active site
1097677003382	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
1097677003383	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097677003384	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097677003385	DNA binding residues [nucleotide binding]
1097677003386	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
1097677003387	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1097677003388	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
1097677003389	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1097677003390	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1097677003391	TPP-binding site [chemical binding]; other site
1097677003392	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1097677003393	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
1097677003394	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1097677003395	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1097677003396	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1097677003397	active site
1097677003398	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1097677003399	Domain of unknown function DUF21; Region: DUF21; pfam01595
1097677003400	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1097677003401	Transporter associated domain; Region: CorC_HlyC; smart01091
1097677003402	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1097677003403	Domain of unknown function DUF21; Region: DUF21; pfam01595
1097677003404	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1097677003405	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1097677003406	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1097677003407	active site
1097677003408	FMN binding site [chemical binding]; other site
1097677003409	substrate binding site [chemical binding]; other site
1097677003410	homotetramer interface [polypeptide binding]; other site
1097677003411	catalytic residue [active]
1097677003412	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1097677003413	putative substrate binding site [chemical binding]; other site
1097677003414	putative ATP binding site [chemical binding]; other site
1097677003415	YceI-like domain; Region: YceI; pfam04264
1097677003416	Domain of unknown function DUF77; Region: DUF77; pfam01910
1097677003417	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1097677003418	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677003419	putative substrate translocation pore; other site
1097677003420	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097677003421	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1097677003422	active site
1097677003423	dimerization interface [polypeptide binding]; other site
1097677003424	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097677003425	DNA binding residues [nucleotide binding]
1097677003426	dimerization interface [polypeptide binding]; other site
1097677003427	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1097677003428	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1097677003429	ATP binding site [chemical binding]; other site
1097677003430	Mg2+ binding site [ion binding]; other site
1097677003431	G-X-G motif; other site
1097677003432	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097677003433	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677003434	active site
1097677003435	phosphorylation site [posttranslational modification]
1097677003436	intermolecular recognition site; other site
1097677003437	dimerization interface [polypeptide binding]; other site
1097677003438	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1097677003439	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
1097677003440	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
1097677003441	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
1097677003442	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1097677003443	homodimer interface [polypeptide binding]; other site
1097677003444	substrate-cofactor binding pocket; other site
1097677003445	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677003446	catalytic residue [active]
1097677003447	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677003448	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1097677003449	NAD(P) binding site [chemical binding]; other site
1097677003450	active site
1097677003451	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097677003452	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677003453	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1097677003454	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1097677003455	active site
1097677003456	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1097677003457	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1097677003458	substrate binding site [chemical binding]; other site
1097677003459	ligand binding site [chemical binding]; other site
1097677003460	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1097677003461	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1097677003462	substrate binding site [chemical binding]; other site
1097677003463	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1097677003464	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1097677003465	hinge; other site
1097677003466	active site
1097677003467	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1097677003468	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1097677003469	putative acyl-acceptor binding pocket; other site
1097677003470	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1097677003471	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1097677003472	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1097677003473	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1097677003474	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1097677003475	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1097677003476	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1097677003477	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1097677003478	active site
1097677003479	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097677003480	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
1097677003481	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1097677003482	thiamine monophosphate kinase; Provisional; Region: PRK05731
1097677003483	ATP binding site [chemical binding]; other site
1097677003484	dimerization interface [polypeptide binding]; other site
1097677003485	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1097677003486	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1097677003487	MoxR-like ATPases [General function prediction only]; Region: COG0714
1097677003488	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097677003489	Walker A motif; other site
1097677003490	ATP binding site [chemical binding]; other site
1097677003491	Walker B motif; other site
1097677003492	arginine finger; other site
1097677003493	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1097677003494	Protein of unknown function DUF58; Region: DUF58; pfam01882
1097677003495	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1097677003496	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1097677003497	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1097677003498	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1097677003499	ssDNA binding site; other site
1097677003500	generic binding surface II; other site
1097677003501	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097677003502	ATP binding site [chemical binding]; other site
1097677003503	putative Mg++ binding site [ion binding]; other site
1097677003504	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097677003505	nucleotide binding region [chemical binding]; other site
1097677003506	ATP-binding site [chemical binding]; other site
1097677003507	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK13964
1097677003508	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1097677003509	active site
1097677003510	(T/H)XGH motif; other site
1097677003511	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
1097677003512	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1097677003513	ribonuclease III; Reviewed; Region: rnc; PRK00102
1097677003514	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1097677003515	dimerization interface [polypeptide binding]; other site
1097677003516	active site
1097677003517	metal binding site [ion binding]; metal-binding site
1097677003518	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1097677003519	dsRNA binding site [nucleotide binding]; other site
1097677003520	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1097677003521	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1097677003522	DNA binding site [nucleotide binding]
1097677003523	catalytic residue [active]
1097677003524	H2TH interface [polypeptide binding]; other site
1097677003525	putative catalytic residues [active]
1097677003526	turnover-facilitating residue; other site
1097677003527	intercalation triad [nucleotide binding]; other site
1097677003528	8OG recognition residue [nucleotide binding]; other site
1097677003529	putative reading head residues; other site
1097677003530	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1097677003531	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1097677003532	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1097677003533	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1097677003534	AAA domain; Region: AAA_23; pfam13476
1097677003535	Walker A/P-loop; other site
1097677003536	ATP binding site [chemical binding]; other site
1097677003537	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1097677003538	ABC transporter signature motif; other site
1097677003539	Walker B; other site
1097677003540	D-loop; other site
1097677003541	H-loop/switch region; other site
1097677003542	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1097677003543	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1097677003544	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097677003545	signal recognition particle protein; Provisional; Region: PRK10867
1097677003546	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1097677003547	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1097677003548	P loop; other site
1097677003549	GTP binding site [chemical binding]; other site
1097677003550	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1097677003551	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1097677003552	active site
1097677003553	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097677003554	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1097677003555	carboxylate-amine ligase; Provisional; Region: PRK13517
1097677003556	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
1097677003557	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
1097677003558	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1097677003559	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1097677003560	G-X-X-G motif; other site
1097677003561	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1097677003562	RimM N-terminal domain; Region: RimM; pfam01782
1097677003563	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1097677003564	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1097677003565	active site
1097677003566	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1097677003567	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1097677003568	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1097677003569	Catalytic site [active]
1097677003570	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1097677003571	RNA/DNA hybrid binding site [nucleotide binding]; other site
1097677003572	active site
1097677003573	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
1097677003574	hypothetical protein; Reviewed; Region: PRK12497
1097677003575	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1097677003576	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1097677003577	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1097677003578	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1097677003579	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1097677003580	DNA protecting protein DprA; Region: dprA; TIGR00732
1097677003581	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1097677003582	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1097677003583	active site
1097677003584	DNA binding site [nucleotide binding]
1097677003585	Int/Topo IB signature motif; other site
1097677003586	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1097677003587	Peptidase family M23; Region: Peptidase_M23; pfam01551
1097677003588	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
1097677003589	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677003590	putative substrate translocation pore; other site
1097677003591	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677003592	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1097677003593	rRNA interaction site [nucleotide binding]; other site
1097677003594	S8 interaction site; other site
1097677003595	putative laminin-1 binding site; other site
1097677003596	elongation factor Ts; Provisional; Region: tsf; PRK09377
1097677003597	UBA/TS-N domain; Region: UBA; pfam00627
1097677003598	Elongation factor TS; Region: EF_TS; pfam00889
1097677003599	Elongation factor TS; Region: EF_TS; pfam00889
1097677003600	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1097677003601	putative nucleotide binding site [chemical binding]; other site
1097677003602	uridine monophosphate binding site [chemical binding]; other site
1097677003603	homohexameric interface [polypeptide binding]; other site
1097677003604	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1097677003605	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1097677003606	hinge region; other site
1097677003607	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1097677003608	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1097677003609	DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543
1097677003610	DivIVA domain; Region: DivI1A_domain; TIGR03544
1097677003611	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1097677003612	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1097677003613	catalytic residue [active]
1097677003614	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1097677003615	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097677003616	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1097677003617	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1097677003618	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1097677003619	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1097677003620	glycogen branching enzyme; Provisional; Region: PRK05402
1097677003621	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1097677003622	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1097677003623	active site
1097677003624	catalytic site [active]
1097677003625	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1097677003626	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
1097677003627	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
1097677003628	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1097677003629	active site
1097677003630	homodimer interface [polypeptide binding]; other site
1097677003631	catalytic site [active]
1097677003632	acceptor binding site [chemical binding]; other site
1097677003633	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
1097677003634	putative homodimer interface [polypeptide binding]; other site
1097677003635	putative active site pocket [active]
1097677003636	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
1097677003637	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1097677003638	active site
1097677003639	catalytic triad [active]
1097677003640	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
1097677003641	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1097677003642	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1097677003643	active site
1097677003644	catalytic site [active]
1097677003645	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1097677003646	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1097677003647	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097677003648	catalytic residue [active]
1097677003649	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
1097677003650	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1097677003651	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1097677003652	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1097677003653	nucleotide binding pocket [chemical binding]; other site
1097677003654	K-X-D-G motif; other site
1097677003655	catalytic site [active]
1097677003656	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1097677003657	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1097677003658	Helix-hairpin-helix motif; Region: HHH; pfam00633
1097677003659	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1097677003660	Dimer interface [polypeptide binding]; other site
1097677003661	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
1097677003662	META domain; Region: META; pfam03724
1097677003663	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1097677003664	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1097677003665	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1097677003666	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1097677003667	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1097677003668	GatB domain; Region: GatB_Yqey; smart00845
1097677003669	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1097677003670	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677003671	Walker A/P-loop; other site
1097677003672	ATP binding site [chemical binding]; other site
1097677003673	ABC transporter signature motif; other site
1097677003674	Walker B; other site
1097677003675	D-loop; other site
1097677003676	H-loop/switch region; other site
1097677003677	ABC transporter; Region: ABC_tran_2; pfam12848
1097677003678	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1097677003679	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1097677003680	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1097677003681	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
1097677003682	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097677003683	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097677003684	acyl-activating enzyme (AAE) consensus motif; other site
1097677003685	AMP binding site [chemical binding]; other site
1097677003686	active site
1097677003687	CoA binding site [chemical binding]; other site
1097677003688	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1097677003689	hydrophobic ligand binding site; other site
1097677003690	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1097677003691	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1097677003692	short chain dehydrogenase; Provisional; Region: PRK07109
1097677003693	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
1097677003694	putative NAD(P) binding site [chemical binding]; other site
1097677003695	active site
1097677003696	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
1097677003697	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097677003698	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097677003699	acyl-activating enzyme (AAE) consensus motif; other site
1097677003700	AMP binding site [chemical binding]; other site
1097677003701	active site
1097677003702	CoA binding site [chemical binding]; other site
1097677003703	short chain dehydrogenase; Provisional; Region: PRK06197
1097677003704	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1097677003705	putative NAD(P) binding site [chemical binding]; other site
1097677003706	active site
1097677003707	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1097677003708	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
1097677003709	metal binding site [ion binding]; metal-binding site
1097677003710	no orthologs in Cmm and Cms
1097677003711	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1097677003712	active site
1097677003713	metal binding site [ion binding]; metal-binding site
1097677003714	homotetramer interface [polypeptide binding]; other site
1097677003715	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1097677003716	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1097677003717	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
1097677003718	Moco binding site; other site
1097677003719	metal coordination site [ion binding]; other site
1097677003720	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1097677003721	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217
1097677003722	FAD binding pocket [chemical binding]; other site
1097677003723	FAD binding motif [chemical binding]; other site
1097677003724	phosphate binding motif [ion binding]; other site
1097677003725	beta-alpha-beta structure motif; other site
1097677003726	NAD binding pocket [chemical binding]; other site
1097677003727	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
1097677003728	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
1097677003729	DNA polymerase IV; Validated; Region: PRK03858
1097677003730	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1097677003731	active site
1097677003732	DNA binding site [nucleotide binding]
1097677003733	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1097677003734	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1097677003735	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1097677003736	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
1097677003737	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
1097677003738	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
1097677003739	catalytic site [active]
1097677003740	active site
1097677003741	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1097677003742	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
1097677003743	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
1097677003744	active site
1097677003745	catalytic site [active]
1097677003746	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1097677003747	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1097677003748	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1097677003749	active site
1097677003750	catalytic site [active]
1097677003751	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
1097677003752	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
1097677003753	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1097677003754	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
1097677003755	Walker A/P-loop; other site
1097677003756	ATP binding site [chemical binding]; other site
1097677003757	Q-loop/lid; other site
1097677003758	ABC transporter signature motif; other site
1097677003759	Walker B; other site
1097677003760	D-loop; other site
1097677003761	H-loop/switch region; other site
1097677003762	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677003763	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1097677003764	Q-loop/lid; other site
1097677003765	ABC transporter signature motif; other site
1097677003766	Walker B; other site
1097677003767	D-loop; other site
1097677003768	H-loop/switch region; other site
1097677003769	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1097677003770	hypothetical protein; Provisional; Region: PRK06547
1097677003771	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
1097677003772	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1097677003773	catalytic site [active]
1097677003774	putative active site [active]
1097677003775	putative substrate binding site [chemical binding]; other site
1097677003776	dimer interface [polypeptide binding]; other site
1097677003777	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1097677003778	catalytic residues [active]
1097677003779	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1097677003780	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1097677003781	homodimer interface [polypeptide binding]; other site
1097677003782	NAD binding pocket [chemical binding]; other site
1097677003783	ATP binding pocket [chemical binding]; other site
1097677003784	Mg binding site [ion binding]; other site
1097677003785	active-site loop [active]
1097677003786	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1097677003787	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097677003788	MarR family; Region: MarR_2; pfam12802
1097677003789	MarR family; Region: MarR_2; cl17246
1097677003790	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1097677003791	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677003792	Walker A/P-loop; other site
1097677003793	ATP binding site [chemical binding]; other site
1097677003794	Q-loop/lid; other site
1097677003795	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1097677003796	ABC transporter; Region: ABC_tran_2; pfam12848
1097677003797	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1097677003798	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1097677003799	active site
1097677003800	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1097677003801	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1097677003802	active site
1097677003803	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1097677003804	catalytic triad [active]
1097677003805	dimer interface [polypeptide binding]; other site
1097677003806	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965
1097677003807	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1097677003808	apolar tunnel; other site
1097677003809	heme binding site [chemical binding]; other site
1097677003810	dimerization interface [polypeptide binding]; other site
1097677003811	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1097677003812	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1097677003813	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
1097677003814	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
1097677003815	Zn binding site [ion binding]; other site
1097677003816	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1097677003817	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1097677003818	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1097677003819	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
1097677003820	putative DNA binding site [nucleotide binding]; other site
1097677003821	catalytic residue [active]
1097677003822	putative H2TH interface [polypeptide binding]; other site
1097677003823	putative catalytic residues [active]
1097677003824	N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119
1097677003825	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1097677003826	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1097677003827	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1097677003828	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1097677003829	dimerization interface [polypeptide binding]; other site
1097677003830	DPS ferroxidase diiron center [ion binding]; other site
1097677003831	ion pore; other site
1097677003832	trigger factor; Provisional; Region: tig; PRK01490
1097677003833	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1097677003834	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1097677003835	Clp protease; Region: CLP_protease; pfam00574
1097677003836	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1097677003837	oligomer interface [polypeptide binding]; other site
1097677003838	active site residues [active]
1097677003839	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
1097677003840	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1097677003841	oligomer interface [polypeptide binding]; other site
1097677003842	active site residues [active]
1097677003843	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
1097677003844	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1097677003845	active site
1097677003846	dimer interface [polypeptide binding]; other site
1097677003847	non-prolyl cis peptide bond; other site
1097677003848	insertion regions; other site
1097677003849	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1097677003850	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1097677003851	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097677003852	Walker A motif; other site
1097677003853	ATP binding site [chemical binding]; other site
1097677003854	Walker B motif; other site
1097677003855	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1097677003856	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1097677003857	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1097677003858	active site
1097677003859	Zn binding site [ion binding]; other site
1097677003860	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1097677003861	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097677003862	S-adenosylmethionine binding site [chemical binding]; other site
1097677003863	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097677003864	Coenzyme A binding pocket [chemical binding]; other site
1097677003865	valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
1097677003866	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1097677003867	active site
1097677003868	HIGH motif; other site
1097677003869	nucleotide binding site [chemical binding]; other site
1097677003870	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1097677003871	active site
1097677003872	KMSKS motif; other site
1097677003873	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1097677003874	tRNA binding surface [nucleotide binding]; other site
1097677003875	anticodon binding site; other site
1097677003876	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
1097677003877	active site
1097677003878	substrate-binding site [chemical binding]; other site
1097677003879	metal-binding site [ion binding]
1097677003880	GTP binding site [chemical binding]; other site
1097677003881	transcriptional repressor DicA; Reviewed; Region: PRK09706
1097677003882	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097677003883	non-specific DNA binding site [nucleotide binding]; other site
1097677003884	salt bridge; other site
1097677003885	sequence-specific DNA binding site [nucleotide binding]; other site
1097677003886	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1097677003887	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1097677003888	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097677003889	Walker A/P-loop; other site
1097677003890	ATP binding site [chemical binding]; other site
1097677003891	Q-loop/lid; other site
1097677003892	ABC transporter signature motif; other site
1097677003893	Walker B; other site
1097677003894	D-loop; other site
1097677003895	H-loop/switch region; other site
1097677003896	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1097677003897	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097677003898	Walker A/P-loop; other site
1097677003899	ATP binding site [chemical binding]; other site
1097677003900	Q-loop/lid; other site
1097677003901	ABC transporter signature motif; other site
1097677003902	Walker B; other site
1097677003903	D-loop; other site
1097677003904	H-loop/switch region; other site
1097677003905	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1097677003906	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1097677003907	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677003908	putative PBP binding loops; other site
1097677003909	dimer interface [polypeptide binding]; other site
1097677003910	ABC-ATPase subunit interface; other site
1097677003911	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1097677003912	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677003913	dimer interface [polypeptide binding]; other site
1097677003914	conserved gate region; other site
1097677003915	putative PBP binding loops; other site
1097677003916	ABC-ATPase subunit interface; other site
1097677003917	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1097677003918	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
1097677003919	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677003920	Cmm ortholog CMM_1480; no Cms ortholog
1097677003921	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1097677003922	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
1097677003923	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1097677003924	HIGH motif; other site
1097677003925	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1097677003926	active site
1097677003927	KMSKS motif; other site
1097677003928	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
1097677003929	tRNA binding surface [nucleotide binding]; other site
1097677003930	anticodon binding site; other site
1097677003931	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1097677003932	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1097677003933	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1097677003934	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
1097677003935	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1097677003936	active site
1097677003937	multimer interface [polypeptide binding]; other site
1097677003938	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
1097677003939	putative active site [active]
1097677003940	redox center [active]
1097677003941	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1097677003942	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1097677003943	homodimer interface [polypeptide binding]; other site
1097677003944	oligonucleotide binding site [chemical binding]; other site
1097677003945	Protein of unknown function (DUF4031); Region: DUF4031; pfam13223
1097677003946	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1097677003947	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1097677003948	GTPase CgtA; Reviewed; Region: obgE; PRK12296
1097677003949	GTP1/OBG; Region: GTP1_OBG; pfam01018
1097677003950	Obg GTPase; Region: Obg; cd01898
1097677003951	G1 box; other site
1097677003952	GTP/Mg2+ binding site [chemical binding]; other site
1097677003953	Switch I region; other site
1097677003954	G2 box; other site
1097677003955	G3 box; other site
1097677003956	Switch II region; other site
1097677003957	G4 box; other site
1097677003958	G5 box; other site
1097677003959	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1097677003960	gamma-glutamyl kinase; Provisional; Region: PRK12314
1097677003961	substrate binding site [chemical binding]; other site
1097677003962	nucleotide binding site [chemical binding]; other site
1097677003963	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1097677003964	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1097677003965	putative catalytic cysteine [active]
1097677003966	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1097677003967	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1097677003968	active site
1097677003969	(T/H)XGH motif; other site
1097677003970	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
1097677003971	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
1097677003972	Nuclease-related domain; Region: NERD; pfam08378
1097677003973	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1097677003974	active site
1097677003975	catalytic triad [active]
1097677003976	oxyanion hole [active]
1097677003977	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1097677003978	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1097677003979	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1097677003980	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1097677003981	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1097677003982	putative substrate binding site [chemical binding]; other site
1097677003983	putative ATP binding site [chemical binding]; other site
1097677003984	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1097677003985	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1097677003986	active site
1097677003987	phosphorylation site [posttranslational modification]
1097677003988	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1097677003989	active site
1097677003990	P-loop; other site
1097677003991	phosphorylation site [posttranslational modification]
1097677003992	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1097677003993	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1097677003994	dimerization domain swap beta strand [polypeptide binding]; other site
1097677003995	regulatory protein interface [polypeptide binding]; other site
1097677003996	active site
1097677003997	regulatory phosphorylation site [posttranslational modification]; other site
1097677003998	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677003999	NAD(P) binding site [chemical binding]; other site
1097677004000	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677004001	NAD(P) binding site [chemical binding]; other site
1097677004002	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1097677004003	active site
1097677004004	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1097677004005	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097677004006	ATP binding site [chemical binding]; other site
1097677004007	putative Mg++ binding site [ion binding]; other site
1097677004008	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097677004009	nucleotide binding region [chemical binding]; other site
1097677004010	ATP-binding site [chemical binding]; other site
1097677004011	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
1097677004012	short chain dehydrogenase; Provisional; Region: PRK06197
1097677004013	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677004014	NAD(P) binding site [chemical binding]; other site
1097677004015	active site
1097677004016	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
1097677004017	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097677004018	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677004019	homodimer interface [polypeptide binding]; other site
1097677004020	catalytic residue [active]
1097677004021	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1097677004022	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097677004023	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097677004024	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097677004025	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1097677004026	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677004027	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1097677004028	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1097677004029	NAD(P) binding site [chemical binding]; other site
1097677004030	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1097677004031	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097677004032	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1097677004033	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
1097677004034	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
1097677004035	active site
1097677004036	PHP Thumb interface [polypeptide binding]; other site
1097677004037	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1097677004038	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1097677004039	generic binding surface II; other site
1097677004040	generic binding surface I; other site
1097677004041	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
1097677004042	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1097677004043	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1097677004044	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1097677004045	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1097677004046	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
1097677004047	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097677004048	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097677004049	active site
1097677004050	catalytic tetrad [active]
1097677004051	Uncharacterized conserved protein [Function unknown]; Region: COG4850
1097677004052	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
1097677004053	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
1097677004054	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677004055	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
1097677004056	Walker A/P-loop; other site
1097677004057	ATP binding site [chemical binding]; other site
1097677004058	Q-loop/lid; other site
1097677004059	ABC transporter signature motif; other site
1097677004060	Walker B; other site
1097677004061	D-loop; other site
1097677004062	H-loop/switch region; other site
1097677004063	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1097677004064	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
1097677004065	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1097677004066	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
1097677004067	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
1097677004068	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
1097677004069	malonyl-CoA binding site [chemical binding]; other site
1097677004070	dimer interface [polypeptide binding]; other site
1097677004071	active site
1097677004072	product binding site; other site
1097677004073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1097677004074	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097677004075	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1097677004076	UbiA prenyltransferase family; Region: UbiA; pfam01040
1097677004077	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097677004078	Coenzyme A binding pocket [chemical binding]; other site
1097677004079	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1097677004080	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097677004081	Coenzyme A binding pocket [chemical binding]; other site
1097677004082	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1097677004083	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1097677004084	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1097677004085	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1097677004086	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1097677004087	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677004088	Walker A/P-loop; other site
1097677004089	ATP binding site [chemical binding]; other site
1097677004090	Q-loop/lid; other site
1097677004091	ABC transporter signature motif; other site
1097677004092	Walker B; other site
1097677004093	D-loop; other site
1097677004094	H-loop/switch region; other site
1097677004095	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
1097677004096	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1097677004097	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677004098	Walker A/P-loop; other site
1097677004099	ATP binding site [chemical binding]; other site
1097677004100	Q-loop/lid; other site
1097677004101	ABC transporter signature motif; other site
1097677004102	Walker B; other site
1097677004103	D-loop; other site
1097677004104	H-loop/switch region; other site
1097677004105	Aminotransferase class IV; Region: Aminotran_4; pfam01063
1097677004106	substrate-cofactor binding pocket; other site
1097677004107	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677004108	catalytic residue [active]
1097677004109	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1097677004110	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1097677004111	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1097677004112	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1097677004113	HIGH motif; other site
1097677004114	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1097677004115	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1097677004116	active site
1097677004117	KMSKS motif; other site
1097677004118	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1097677004119	tRNA binding surface [nucleotide binding]; other site
1097677004120	comEA protein; Region: comE; TIGR01259
1097677004121	Competence protein; Region: Competence; pfam03772
1097677004122	hypothetical protein; Reviewed; Region: PRK07914
1097677004123	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1097677004124	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1097677004125	nudix motif; other site
1097677004126	aspartate aminotransferase; Provisional; Region: PRK05764
1097677004127	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097677004128	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677004129	homodimer interface [polypeptide binding]; other site
1097677004130	catalytic residue [active]
1097677004131	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
1097677004132	Amidohydrolase; Region: Amidohydro_4; pfam13147
1097677004133	active site
1097677004135	GTP-binding protein LepA; Provisional; Region: PRK05433
1097677004136	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1097677004137	G1 box; other site
1097677004138	putative GEF interaction site [polypeptide binding]; other site
1097677004139	GTP/Mg2+ binding site [chemical binding]; other site
1097677004140	Switch I region; other site
1097677004141	G2 box; other site
1097677004142	G3 box; other site
1097677004143	Switch II region; other site
1097677004144	G4 box; other site
1097677004145	G5 box; other site
1097677004146	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1097677004147	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1097677004148	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1097677004149	Domain of unknown function (DUF1990); Region: DUF1990; pfam09348
1097677004150	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1097677004151	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1097677004152	coproporphyrinogen III oxidase; Validated; Region: PRK05628
1097677004153	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097677004154	FeS/SAM binding site; other site
1097677004155	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1097677004156	active site
1097677004157	metal binding site [ion binding]; metal-binding site
1097677004158	Tic20-like protein; Region: Tic20; pfam09685
1097677004159	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1097677004160	chaperone protein DnaJ; Provisional; Region: PRK14278
1097677004161	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1097677004162	HSP70 interaction site [polypeptide binding]; other site
1097677004163	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1097677004164	Zn binding sites [ion binding]; other site
1097677004165	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1097677004166	dimer interface [polypeptide binding]; other site
1097677004167	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
1097677004168	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1097677004169	nucleotide binding site/active site [active]
1097677004170	HIT family signature motif; other site
1097677004171	catalytic residue [active]
1097677004172	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1097677004173	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245
1097677004174	nucleic acid binding region [nucleotide binding]; other site
1097677004175	G-X-X-G motif; other site
1097677004176	PhoH-like protein; Region: PhoH; pfam02562
1097677004177	metal-binding heat shock protein; Provisional; Region: PRK00016
1097677004178	Domain of unknown function DUF21; Region: DUF21; pfam01595
1097677004179	FOG: CBS domain [General function prediction only]; Region: COG0517
1097677004180	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1097677004181	GTPase Era; Reviewed; Region: era; PRK00089
1097677004182	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1097677004183	G1 box; other site
1097677004184	GTP/Mg2+ binding site [chemical binding]; other site
1097677004185	Switch I region; other site
1097677004186	G2 box; other site
1097677004187	Switch II region; other site
1097677004188	G3 box; other site
1097677004189	G4 box; other site
1097677004190	G5 box; other site
1097677004191	KH domain; Region: KH_2; pfam07650
1097677004192	Histidine kinase; Region: HisKA_3; pfam07730
1097677004193	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1097677004194	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097677004195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677004196	active site
1097677004197	phosphorylation site [posttranslational modification]
1097677004198	intermolecular recognition site; other site
1097677004199	dimerization interface [polypeptide binding]; other site
1097677004200	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097677004201	DNA binding residues [nucleotide binding]
1097677004202	dimerization interface [polypeptide binding]; other site
1097677004203	Putative esterase; Region: Esterase; pfam00756
1097677004204	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1097677004205	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1097677004206	2-isopropylmalate synthase; Validated; Region: PRK03739
1097677004207	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1097677004208	active site
1097677004209	catalytic residues [active]
1097677004210	metal binding site [ion binding]; metal-binding site
1097677004211	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1097677004212	Predicted membrane protein [Function unknown]; Region: COG2860
1097677004213	UPF0126 domain; Region: UPF0126; pfam03458
1097677004214	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1097677004215	Recombination protein O N terminal; Region: RecO_N; pfam11967
1097677004216	Recombination protein O C terminal; Region: RecO_C; pfam02565
1097677004217	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1097677004218	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
1097677004219	catalytic residue [active]
1097677004220	putative FPP diphosphate  binding site; other site
1097677004221	putative FPP binding hydrophobic cleft; other site
1097677004222	dimer interface [polypeptide binding]; other site
1097677004223	putative IPP diphosphate binding site; other site
1097677004224	putative oxidoreductase; Provisional; Region: PRK11579
1097677004225	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097677004226	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1097677004227	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1097677004228	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1097677004229	motif 1; other site
1097677004230	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1097677004231	active site
1097677004232	motif 2; other site
1097677004233	motif 3; other site
1097677004234	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1097677004235	anticodon binding site; other site
1097677004236	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
1097677004237	putative deacylase active site [active]
1097677004238	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1097677004239	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1097677004240	catalytic residues [active]
1097677004241	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1097677004242	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1097677004243	FMN binding site [chemical binding]; other site
1097677004244	active site
1097677004245	catalytic residues [active]
1097677004246	substrate binding site [chemical binding]; other site
1097677004247	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
1097677004248	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1097677004249	Zn2+ binding site [ion binding]; other site
1097677004250	Mg2+ binding site [ion binding]; other site
1097677004251	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1097677004252	DNA primase; Validated; Region: dnaG; PRK05667
1097677004253	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1097677004254	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1097677004255	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1097677004256	active site
1097677004257	metal binding site [ion binding]; metal-binding site
1097677004258	interdomain interaction site; other site
1097677004259	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1097677004260	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1097677004261	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1097677004262	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
1097677004263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677004264	dimer interface [polypeptide binding]; other site
1097677004265	conserved gate region; other site
1097677004266	putative PBP binding loops; other site
1097677004267	ABC-ATPase subunit interface; other site
1097677004268	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1097677004269	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677004270	dimer interface [polypeptide binding]; other site
1097677004271	conserved gate region; other site
1097677004272	ABC-ATPase subunit interface; other site
1097677004273	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1097677004274	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097677004275	Walker A/P-loop; other site
1097677004276	ATP binding site [chemical binding]; other site
1097677004277	Q-loop/lid; other site
1097677004278	ABC transporter signature motif; other site
1097677004279	Walker B; other site
1097677004280	D-loop; other site
1097677004281	H-loop/switch region; other site
1097677004282	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097677004283	Walker A/P-loop; other site
1097677004284	ATP binding site [chemical binding]; other site
1097677004285	Q-loop/lid; other site
1097677004286	ABC transporter signature motif; other site
1097677004287	Walker B; other site
1097677004288	D-loop; other site
1097677004289	H-loop/switch region; other site
1097677004290	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1097677004291	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1097677004292	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097677004293	Walker A/P-loop; other site
1097677004294	ATP binding site [chemical binding]; other site
1097677004295	Q-loop/lid; other site
1097677004296	ABC transporter signature motif; other site
1097677004297	Walker B; other site
1097677004298	D-loop; other site
1097677004299	H-loop/switch region; other site
1097677004300	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159
1097677004301	putative ligand binding site [chemical binding]; other site
1097677004302	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1097677004303	putative NAD binding site [chemical binding]; other site
1097677004304	catalytic site [active]
1097677004305	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1097677004306	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1097677004307	active site
1097677004308	catalytic residues [active]
1097677004309	metal binding site [ion binding]; metal-binding site
1097677004310	Magnesium transporter NIPA; Region: Mg_trans_NIPA; pfam05653
1097677004311	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
1097677004312	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097677004313	putative ADP-binding pocket [chemical binding]; other site
1097677004314	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1097677004315	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
1097677004316	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1097677004317	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1097677004318	NADP binding site [chemical binding]; other site
1097677004319	active site
1097677004320	putative substrate binding site [chemical binding]; other site
1097677004321	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1097677004322	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1097677004323	NADP-binding site; other site
1097677004324	homotetramer interface [polypeptide binding]; other site
1097677004325	substrate binding site [chemical binding]; other site
1097677004326	homodimer interface [polypeptide binding]; other site
1097677004327	active site
1097677004328	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
1097677004329	putative acyl transferase; Provisional; Region: PRK10502
1097677004330	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
1097677004331	putative trimer interface [polypeptide binding]; other site
1097677004332	putative active site [active]
1097677004333	putative substrate binding site [chemical binding]; other site
1097677004334	putative CoA binding site [chemical binding]; other site
1097677004335	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1097677004336	putative glycosyl transferase; Provisional; Region: PRK10125
1097677004337	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1097677004338	putative colanic acid biosynthesis protein; Provisional; Region: wcaD; PRK09953
1097677004339	putative glycosyl transferase; Provisional; Region: PRK10063
1097677004340	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097677004341	active site
1097677004342	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1097677004343	trimer interface [polypeptide binding]; other site
1097677004344	active site
1097677004345	substrate binding site [chemical binding]; other site
1097677004346	CoA binding site [chemical binding]; other site
1097677004347	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1097677004348	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1097677004349	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1097677004350	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1097677004351	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1097677004352	DNA-binding site [nucleotide binding]; DNA binding site
1097677004353	RNA-binding motif; other site
1097677004354	bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975
1097677004355	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444
1097677004356	active site
1097677004357	DNA binding site [nucleotide binding]
1097677004358	catalytic site [active]
1097677004359	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
1097677004360	Predicted transcriptional regulators [Transcription]; Region: COG1695
1097677004361	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1097677004362	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
1097677004363	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1097677004364	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1097677004365	dimer interface [polypeptide binding]; other site
1097677004366	active site
1097677004367	acyl carrier protein; Provisional; Region: acpP; PRK00982
1097677004368	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1097677004369	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1097677004370	dimer interface [polypeptide binding]; other site
1097677004371	active site
1097677004372	CoA binding pocket [chemical binding]; other site
1097677004373	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1097677004374	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1097677004375	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1097677004376	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1097677004377	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1097677004378	dimer interface [polypeptide binding]; other site
1097677004379	TPP-binding site [chemical binding]; other site
1097677004380	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1097677004381	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1097677004382	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
1097677004383	dimer interface [polypeptide binding]; other site
1097677004384	catalytic triad [active]
1097677004385	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1097677004386	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677004387	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1097677004388	BioY family; Region: BioY; pfam02632
1097677004389	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1097677004390	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1097677004391	Walker A/P-loop; other site
1097677004392	ATP binding site [chemical binding]; other site
1097677004393	Q-loop/lid; other site
1097677004394	ABC transporter signature motif; other site
1097677004395	Walker B; other site
1097677004396	D-loop; other site
1097677004397	H-loop/switch region; other site
1097677004398	Cobalt transport protein; Region: CbiQ; cl00463
1097677004399	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1097677004400	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1097677004401	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
1097677004402	Putative zinc ribbon domain; Region: DUF164; pfam02591
1097677004403	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1097677004404	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1097677004405	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1097677004406	oligomerization interface [polypeptide binding]; other site
1097677004407	active site
1097677004408	metal binding site [ion binding]; metal-binding site
1097677004409	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1097677004410	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1097677004411	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1097677004412	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
1097677004413	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1097677004414	metal binding triad; other site
1097677004415	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1097677004416	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1097677004417	metal binding triad; other site
1097677004418	glutamine synthetase, type I; Region: GlnA; TIGR00653
1097677004419	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1097677004420	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1097677004421	RDD family; Region: RDD; pfam06271
1097677004422	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
1097677004423	HSP70 interaction site [polypeptide binding]; other site
1097677004424	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
1097677004425	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1097677004426	active site
1097677004427	ATP binding site [chemical binding]; other site
1097677004428	substrate binding site [chemical binding]; other site
1097677004429	activation loop (A-loop); other site
1097677004430	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1097677004431	E3 interaction surface; other site
1097677004432	lipoyl attachment site [posttranslational modification]; other site
1097677004433	e3 binding domain; Region: E3_binding; pfam02817
1097677004434	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
1097677004435	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1097677004436	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1097677004437	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097677004438	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1097677004439	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1097677004440	interface (dimer of trimers) [polypeptide binding]; other site
1097677004441	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1097677004442	Substrate-binding/catalytic site; other site
1097677004443	Zn-binding sites [ion binding]; other site
1097677004444	PAC2 family; Region: PAC2; pfam09754
1097677004445	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677004446	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097677004447	putative substrate translocation pore; other site
1097677004448	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1097677004449	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097677004450	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1097677004451	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097677004452	DNA binding residues [nucleotide binding]
1097677004453	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1097677004454	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1097677004455	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1097677004456	conserved cys residue [active]
1097677004457	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1097677004458	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097677004459	ATP binding site [chemical binding]; other site
1097677004460	Mg2+ binding site [ion binding]; other site
1097677004461	G-X-G motif; other site
1097677004462	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1097677004463	anchoring element; other site
1097677004464	dimer interface [polypeptide binding]; other site
1097677004465	ATP binding site [chemical binding]; other site
1097677004466	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1097677004467	active site
1097677004468	metal binding site [ion binding]; metal-binding site
1097677004469	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1097677004470	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1097677004471	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1097677004472	CAP-like domain; other site
1097677004473	active site
1097677004474	primary dimer interface [polypeptide binding]; other site
1097677004475	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
1097677004476	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
1097677004477	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
1097677004478	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
1097677004479	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1097677004480	trimer interface [polypeptide binding]; other site
1097677004481	active site
1097677004482	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
1097677004483	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
1097677004484	aconitate hydratase; Validated; Region: PRK09277
1097677004485	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1097677004486	substrate binding site [chemical binding]; other site
1097677004487	ligand binding site [chemical binding]; other site
1097677004488	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1097677004489	substrate binding site [chemical binding]; other site
1097677004490	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1097677004491	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1097677004492	TPP-binding site; other site
1097677004493	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1097677004494	PYR/PP interface [polypeptide binding]; other site
1097677004495	dimer interface [polypeptide binding]; other site
1097677004496	TPP binding site [chemical binding]; other site
1097677004497	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1097677004498	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1097677004499	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097677004500	substrate binding site [chemical binding]; other site
1097677004501	oxyanion hole (OAH) forming residues; other site
1097677004502	trimer interface [polypeptide binding]; other site
1097677004503	3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545
1097677004504	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1097677004505	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1097677004506	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
1097677004507	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1097677004508	dimer interface [polypeptide binding]; other site
1097677004509	active site
1097677004510	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
1097677004511	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1097677004512	catalytic site [active]
1097677004513	putative active site [active]
1097677004514	putative substrate binding site [chemical binding]; other site
1097677004515	HRDC domain; Region: HRDC; pfam00570
1097677004516	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
1097677004517	RibD C-terminal domain; Region: RibD_C; cl17279
1097677004518	Fe-S metabolism associated domain; Region: SufE; cl00951
1097677004519	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1097677004520	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1097677004521	active site residue [active]
1097677004522	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1097677004523	active site residue [active]
1097677004524	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
1097677004525	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1097677004526	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1097677004527	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097677004528	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097677004529	active site
1097677004530	catalytic tetrad [active]
1097677004531	Cmm ortholog CMM_1672; Cms ortholog CMS_1656
1097677004532	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
1097677004533	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1097677004534	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
1097677004535	HYR domain; Region: HYR; pfam02494
1097677004536	Cmm homolog CMM_1677; Cms homolog CMS_1718
1097677004537	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1097677004538	nudix motif; other site
1097677004539	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1097677004540	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1097677004541	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097677004542	short chain dehydrogenase; Provisional; Region: PRK07806
1097677004543	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1097677004544	NAD(P) binding site [chemical binding]; other site
1097677004545	active site
1097677004546	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1097677004547	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1097677004548	active site
1097677004549	catalytic site [active]
1097677004550	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
1097677004551	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1097677004552	putative active site [active]
1097677004553	catalytic triad [active]
1097677004554	putative dimer interface [polypeptide binding]; other site
1097677004555	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1097677004556	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097677004557	ATP binding site [chemical binding]; other site
1097677004558	putative Mg++ binding site [ion binding]; other site
1097677004559	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097677004560	nucleotide binding region [chemical binding]; other site
1097677004561	ATP-binding site [chemical binding]; other site
1097677004562	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
1097677004563	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
1097677004564	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
1097677004565	Predicted transcriptional regulator [Transcription]; Region: COG2378
1097677004566	FeoC like transcriptional regulator; Region: FeoC; cl17677
1097677004567	WYL domain; Region: WYL; pfam13280
1097677004568	Predicted transcriptional regulator [Transcription]; Region: COG2378
1097677004569	WYL domain; Region: WYL; pfam13280
1097677004570	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1097677004571	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
1097677004572	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097677004573	S-adenosylmethionine binding site [chemical binding]; other site
1097677004574	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1097677004575	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1097677004576	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097677004577	motif II; other site
1097677004578	PAC2 family; Region: PAC2; pfam09754
1097677004579	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1097677004580	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
1097677004581	active site
1097677004582	HIGH motif; other site
1097677004583	nucleotide binding site [chemical binding]; other site
1097677004584	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1097677004585	active site
1097677004586	KMSKS motif; other site
1097677004587	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
1097677004588	hypothetical protein; Provisional; Region: PRK07906
1097677004589	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
1097677004590	putative metal binding site [ion binding]; other site
1097677004591	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1097677004592	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
1097677004593	oligomer interface [polypeptide binding]; other site
1097677004594	metal binding site [ion binding]; metal-binding site
1097677004595	metal binding site [ion binding]; metal-binding site
1097677004596	putative Cl binding site [ion binding]; other site
1097677004597	basic sphincter; other site
1097677004598	hydrophobic gate; other site
1097677004599	periplasmic entrance; other site
1097677004600	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097677004601	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677004602	NAD(P) binding site [chemical binding]; other site
1097677004603	active site
1097677004604	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677004605	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1097677004606	HSP70 interaction site [polypeptide binding]; other site
1097677004607	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
1097677004608	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1097677004609	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1097677004610	Walker A/P-loop; other site
1097677004611	ATP binding site [chemical binding]; other site
1097677004612	Q-loop/lid; other site
1097677004613	ABC transporter signature motif; other site
1097677004614	Walker B; other site
1097677004615	D-loop; other site
1097677004616	H-loop/switch region; other site
1097677004617	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1097677004618	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677004619	ABC-ATPase subunit interface; other site
1097677004620	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1097677004621	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1097677004622	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1097677004623	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097677004624	ATP binding site [chemical binding]; other site
1097677004625	putative Mg++ binding site [ion binding]; other site
1097677004626	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097677004627	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097677004628	active site
1097677004629	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1097677004630	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1097677004631	putative metal binding site [ion binding]; other site
1097677004632	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1097677004633	active site
1097677004634	metal binding site [ion binding]; metal-binding site
1097677004635	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
1097677004636	active site
1097677004637	catalytic triad [active]
1097677004638	oxyanion hole [active]
1097677004639	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1097677004640	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1097677004641	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1097677004642	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1097677004643	NAD-dependent deacetylase; Provisional; Region: PRK05333
1097677004644	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1097677004645	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1097677004646	catalytic core [active]
1097677004647	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097677004648	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1097677004649	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097677004650	trehalose synthase; Region: treS_nterm; TIGR02456
1097677004651	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
1097677004652	active site
1097677004653	catalytic site [active]
1097677004654	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1097677004655	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1097677004656	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1097677004657	active site
1097677004658	catalytic site [active]
1097677004659	substrate binding site [chemical binding]; other site
1097677004660	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1097677004661	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1097677004662	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677004663	Walker A/P-loop; other site
1097677004664	ATP binding site [chemical binding]; other site
1097677004665	Q-loop/lid; other site
1097677004666	ABC transporter signature motif; other site
1097677004667	Walker B; other site
1097677004668	D-loop; other site
1097677004669	H-loop/switch region; other site
1097677004670	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
1097677004671	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1097677004672	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
1097677004673	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1097677004674	ligand binding site; other site
1097677004675	oligomer interface; other site
1097677004676	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1097677004677	dimer interface [polypeptide binding]; other site
1097677004678	N-terminal domain interface [polypeptide binding]; other site
1097677004679	sulfate 1 binding site; other site
1097677004680	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1097677004681	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097677004682	motif II; other site
1097677004683	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1097677004684	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1097677004685	active site
1097677004686	ATP binding site [chemical binding]; other site
1097677004687	Phosphotransferase enzyme family; Region: APH; pfam01636
1097677004688	substrate binding site [chemical binding]; other site
1097677004689	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677004690	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1097677004691	NAD(P) binding site [chemical binding]; other site
1097677004692	active site
1097677004693	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
1097677004694	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1097677004695	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1097677004696	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677004697	Walker A/P-loop; other site
1097677004698	ATP binding site [chemical binding]; other site
1097677004699	Q-loop/lid; other site
1097677004700	ABC transporter signature motif; other site
1097677004701	Walker B; other site
1097677004702	D-loop; other site
1097677004703	H-loop/switch region; other site
1097677004704	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1097677004705	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1097677004706	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1097677004707	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1097677004708	Walker A/P-loop; other site
1097677004709	ATP binding site [chemical binding]; other site
1097677004710	Q-loop/lid; other site
1097677004711	ABC transporter signature motif; other site
1097677004712	Walker B; other site
1097677004713	D-loop; other site
1097677004714	H-loop/switch region; other site
1097677004715	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
1097677004716	[2Fe-2S] cluster binding site [ion binding]; other site
1097677004717	FeS assembly protein SufD; Region: sufD; TIGR01981
1097677004718	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
1097677004719	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1097677004720	FeS assembly protein SufB; Region: sufB; TIGR01980
1097677004721	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1097677004722	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1097677004723	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1097677004724	UbiA prenyltransferase family; Region: UbiA; pfam01040
1097677004725	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1097677004726	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1097677004727	TPP-binding site [chemical binding]; other site
1097677004728	dimer interface [polypeptide binding]; other site
1097677004729	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1097677004730	PYR/PP interface [polypeptide binding]; other site
1097677004731	dimer interface [polypeptide binding]; other site
1097677004732	TPP binding site [chemical binding]; other site
1097677004733	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1097677004734	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
1097677004735	putative active site [active]
1097677004736	transaldolase; Provisional; Region: PRK03903
1097677004737	catalytic residue [active]
1097677004738	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
1097677004739	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1097677004740	active site
1097677004741	dimer interface [polypeptide binding]; other site
1097677004742	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1097677004743	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1097677004744	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1097677004745	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1097677004746	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
1097677004747	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
1097677004748	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1097677004749	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1097677004750	putative active site [active]
1097677004751	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
1097677004752	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
1097677004753	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1097677004754	triosephosphate isomerase; Provisional; Region: PRK14565
1097677004755	substrate binding site [chemical binding]; other site
1097677004756	dimer interface [polypeptide binding]; other site
1097677004757	catalytic triad [active]
1097677004758	Phosphoglycerate kinase; Region: PGK; pfam00162
1097677004759	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1097677004760	substrate binding site [chemical binding]; other site
1097677004761	hinge regions; other site
1097677004762	ADP binding site [chemical binding]; other site
1097677004763	catalytic site [active]
1097677004764	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1097677004765	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1097677004766	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1097677004767	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1097677004768	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1097677004769	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1097677004770	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1097677004771	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1097677004772	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1097677004773	shikimate kinase; Reviewed; Region: aroK; PRK00131
1097677004774	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1097677004775	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1097677004776	GIY-YIG motif/motif A; other site
1097677004777	active site
1097677004778	catalytic site [active]
1097677004779	putative DNA binding site [nucleotide binding]; other site
1097677004780	metal binding site [ion binding]; metal-binding site
1097677004781	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1097677004782	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1097677004783	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1097677004784	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1097677004785	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1097677004786	excinuclease ABC subunit B; Provisional; Region: PRK05298
1097677004787	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097677004788	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097677004789	nucleotide binding region [chemical binding]; other site
1097677004790	ATP-binding site [chemical binding]; other site
1097677004791	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1097677004792	UvrB/uvrC motif; Region: UVR; pfam02151
1097677004793	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1097677004794	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1097677004795	CoA-binding site [chemical binding]; other site
1097677004796	ATP-binding [chemical binding]; other site
1097677004797	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
1097677004798	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1097677004799	RNA binding site [nucleotide binding]; other site
1097677004800	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1097677004801	RNA binding site [nucleotide binding]; other site
1097677004802	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1097677004803	RNA binding site [nucleotide binding]; other site
1097677004804	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1097677004805	RNA binding site [nucleotide binding]; other site
1097677004806	domain interface; other site
1097677004807	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
1097677004808	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1097677004809	active site
1097677004810	phosphorylation site [posttranslational modification]
1097677004811	DNA polymerase I; Provisional; Region: PRK05755
1097677004812	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1097677004813	active site
1097677004814	metal binding site 1 [ion binding]; metal-binding site
1097677004815	putative 5' ssDNA interaction site; other site
1097677004816	metal binding site 3; metal-binding site
1097677004817	metal binding site 2 [ion binding]; metal-binding site
1097677004818	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1097677004819	putative DNA binding site [nucleotide binding]; other site
1097677004820	putative metal binding site [ion binding]; other site
1097677004821	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1097677004822	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1097677004823	active site
1097677004824	DNA binding site [nucleotide binding]
1097677004825	catalytic site [active]
1097677004826	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1097677004827	CoenzymeA binding site [chemical binding]; other site
1097677004828	subunit interaction site [polypeptide binding]; other site
1097677004829	PHB binding site; other site
1097677004830	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
1097677004831	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677004832	active site
1097677004833	phosphorylation site [posttranslational modification]
1097677004834	intermolecular recognition site; other site
1097677004835	dimerization interface [polypeptide binding]; other site
1097677004836	ANTAR domain; Region: ANTAR; pfam03861
1097677004837	pyruvate kinase; Provisional; Region: PRK06247
1097677004838	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1097677004839	domain interfaces; other site
1097677004840	active site
1097677004841	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1097677004842	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097677004843	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1097677004844	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1097677004845	active site
1097677004846	dimer interface [polypeptide binding]; other site
1097677004847	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1097677004848	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1097677004849	active site
1097677004850	FMN binding site [chemical binding]; other site
1097677004851	substrate binding site [chemical binding]; other site
1097677004852	3Fe-4S cluster binding site [ion binding]; other site
1097677004853	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1097677004854	domain interface; other site
1097677004855	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1097677004856	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1097677004857	substrate binding site [chemical binding]; other site
1097677004858	active site
1097677004859	catalytic residues [active]
1097677004860	heterodimer interface [polypeptide binding]; other site
1097677004861	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1097677004862	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1097677004863	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677004864	catalytic residue [active]
1097677004865	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1097677004866	active site
1097677004867	ribulose/triose binding site [chemical binding]; other site
1097677004868	phosphate binding site [ion binding]; other site
1097677004869	substrate (anthranilate) binding pocket [chemical binding]; other site
1097677004870	product (indole) binding pocket [chemical binding]; other site
1097677004871	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850
1097677004872	anthranilate synthase component I; Provisional; Region: PRK13571
1097677004873	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1097677004874	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1097677004875	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1097677004876	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1097677004877	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1097677004878	substrate binding site [chemical binding]; other site
1097677004879	glutamase interaction surface [polypeptide binding]; other site
1097677004880	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
1097677004881	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
1097677004882	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
1097677004883	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
1097677004884	homodimer interface [polypeptide binding]; other site
1097677004885	putative metal binding site [ion binding]; other site
1097677004886	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1097677004887	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1097677004888	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1097677004889	substrate binding site [chemical binding]; other site
1097677004890	hexamer interface [polypeptide binding]; other site
1097677004891	metal binding site [ion binding]; metal-binding site
1097677004892	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
1097677004893	putative RNA binding site [nucleotide binding]; other site
1097677004894	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1097677004895	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
1097677004896	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1097677004897	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1097677004898	putative active site [active]
1097677004899	substrate binding site [chemical binding]; other site
1097677004900	putative cosubstrate binding site; other site
1097677004901	catalytic site [active]
1097677004902	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1097677004903	substrate binding site [chemical binding]; other site
1097677004904	primosome assembly protein PriA; Provisional; Region: PRK14873
1097677004905	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1097677004906	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1097677004907	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1097677004908	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1097677004909	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1097677004910	Flavoprotein; Region: Flavoprotein; pfam02441
1097677004911	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1097677004912	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1097677004913	TfoX C-terminal domain; Region: TfoX_C; pfam04994
1097677004914	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1097677004915	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1097677004916	catalytic site [active]
1097677004917	G-X2-G-X-G-K; other site
1097677004918	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1097677004919	active site
1097677004920	dimer interface [polypeptide binding]; other site
1097677004921	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1097677004922	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1097677004923	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1097677004924	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1097677004925	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1097677004926	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1097677004927	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1097677004928	IMP binding site; other site
1097677004929	dimer interface [polypeptide binding]; other site
1097677004930	interdomain contacts; other site
1097677004931	partial ornithine binding site; other site
1097677004932	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1097677004933	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1097677004934	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1097677004935	catalytic site [active]
1097677004936	subunit interface [polypeptide binding]; other site
1097677004937	dihydroorotase; Validated; Region: pyrC; PRK09357
1097677004938	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097677004939	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1097677004940	active site
1097677004941	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1097677004942	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1097677004943	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1097677004944	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1097677004945	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1097677004946	active site
1097677004947	acetyl-CoA synthetase; Provisional; Region: PRK00174
1097677004948	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097677004949	acyl-activating enzyme (AAE) consensus motif; other site
1097677004950	AMP binding site [chemical binding]; other site
1097677004951	active site
1097677004952	CoA binding site [chemical binding]; other site
1097677004953	transcription antitermination factor NusB; Region: nusB; TIGR01951
1097677004954	putative RNA binding site [nucleotide binding]; other site
1097677004955	elongation factor P; Validated; Region: PRK00529
1097677004956	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1097677004957	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1097677004958	RNA binding site [nucleotide binding]; other site
1097677004959	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1097677004960	RNA binding site [nucleotide binding]; other site
1097677004961	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1097677004962	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1097677004963	trimer interface [polypeptide binding]; other site
1097677004964	active site
1097677004965	dimer interface [polypeptide binding]; other site
1097677004966	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677004967	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859
1097677004968	NAD(P) binding site [chemical binding]; other site
1097677004969	active site
1097677004970	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1097677004971	active site
1097677004972	dimer interface [polypeptide binding]; other site
1097677004973	metal binding site [ion binding]; metal-binding site
1097677004974	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1097677004975	Shikimate kinase; Region: SKI; pfam01202
1097677004976	ADP binding site [chemical binding]; other site
1097677004977	magnesium binding site [ion binding]; other site
1097677004978	putative shikimate binding site; other site
1097677004979	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1097677004980	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1097677004981	Tetramer interface [polypeptide binding]; other site
1097677004982	active site
1097677004983	FMN-binding site [chemical binding]; other site
1097677004984	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1097677004985	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1097677004986	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1097677004987	shikimate binding site; other site
1097677004988	NAD(P) binding site [chemical binding]; other site
1097677004989	YceG-like family; Region: YceG; pfam02618
1097677004990	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1097677004991	dimerization interface [polypeptide binding]; other site
1097677004992	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
1097677004993	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1097677004994	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1097677004995	motif 1; other site
1097677004996	active site
1097677004997	motif 2; other site
1097677004998	motif 3; other site
1097677004999	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1097677005000	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1097677005001	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1097677005002	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1097677005003	RNA binding surface [nucleotide binding]; other site
1097677005004	recombination factor protein RarA; Reviewed; Region: PRK13342
1097677005005	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097677005006	Walker A motif; other site
1097677005007	ATP binding site [chemical binding]; other site
1097677005008	Walker B motif; other site
1097677005009	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1097677005010	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1097677005011	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1097677005012	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1097677005013	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1097677005014	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1097677005015	Zn2+ binding site [ion binding]; other site
1097677005016	Mg2+ binding site [ion binding]; other site
1097677005017	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1097677005018	synthetase active site [active]
1097677005019	NTP binding site [chemical binding]; other site
1097677005020	metal binding site [ion binding]; metal-binding site
1097677005021	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1097677005022	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1097677005023	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1097677005024	active site residue [active]
1097677005025	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1097677005026	Protein export membrane protein; Region: SecD_SecF; pfam02355
1097677005027	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
1097677005028	Protein export membrane protein; Region: SecD_SecF; cl14618
1097677005029	Preprotein translocase subunit; Region: YajC; pfam02699
1097677005030	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1097677005031	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097677005032	Walker A motif; other site
1097677005033	ATP binding site [chemical binding]; other site
1097677005034	Walker B motif; other site
1097677005035	arginine finger; other site
1097677005036	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1097677005037	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14603
1097677005038	RuvA N terminal domain; Region: RuvA_N; pfam01330
1097677005039	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1097677005040	active site
1097677005041	putative DNA-binding cleft [nucleotide binding]; other site
1097677005042	dimer interface [polypeptide binding]; other site
1097677005043	hypothetical protein; Validated; Region: PRK00110
1097677005044	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1097677005045	Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118
1097677005046	predicted active site [active]
1097677005047	catalytic triad [active]
1097677005048	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1097677005049	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1097677005050	active site
1097677005051	multimer interface [polypeptide binding]; other site
1097677005052	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
1097677005053	nucleotide binding site/active site [active]
1097677005054	HIT family signature motif; other site
1097677005055	catalytic residue [active]
1097677005056	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
1097677005057	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1097677005058	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1097677005059	active site
1097677005060	dimer interface [polypeptide binding]; other site
1097677005061	motif 1; other site
1097677005062	motif 2; other site
1097677005063	motif 3; other site
1097677005064	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1097677005065	anticodon binding site; other site
1097677005066	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1097677005067	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097677005068	DNA binding residues [nucleotide binding]
1097677005069	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1097677005070	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1097677005071	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1097677005072	catalytic residues [active]
1097677005073	dimer interface [polypeptide binding]; other site
1097677005074	Protein of unknown function (DUF664); Region: DUF664; pfam04978
1097677005075	hypothetical protein; Provisional; Region: PRK04233
1097677005076	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1097677005077	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1097677005078	dimerization domain swap beta strand [polypeptide binding]; other site
1097677005079	regulatory protein interface [polypeptide binding]; other site
1097677005080	active site
1097677005081	regulatory phosphorylation site [posttranslational modification]; other site
1097677005082	DAK2 domain; Region: Dak2; cl03685
1097677005083	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1097677005084	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1097677005085	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1097677005086	amphipathic channel; other site
1097677005087	Asn-Pro-Ala signature motifs; other site
1097677005088	glycerol kinase; Provisional; Region: glpK; PRK00047
1097677005089	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
1097677005090	N- and C-terminal domain interface [polypeptide binding]; other site
1097677005091	active site
1097677005092	MgATP binding site [chemical binding]; other site
1097677005093	catalytic site [active]
1097677005094	metal binding site [ion binding]; metal-binding site
1097677005095	putative homotetramer interface [polypeptide binding]; other site
1097677005096	glycerol binding site [chemical binding]; other site
1097677005097	homodimer interface [polypeptide binding]; other site
1097677005098	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
1097677005099	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1097677005100	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1097677005101	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1097677005102	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
1097677005103	Subunit I/III interface [polypeptide binding]; other site
1097677005104	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097677005105	Cytochrome c; Region: Cytochrom_C; pfam00034
1097677005106	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097677005107	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1097677005108	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1097677005109	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1097677005110	iron-sulfur cluster [ion binding]; other site
1097677005111	[2Fe-2S] cluster binding site [ion binding]; other site
1097677005112	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1097677005113	heme bH binding site [chemical binding]; other site
1097677005114	intrachain domain interface; other site
1097677005115	heme bL binding site [chemical binding]; other site
1097677005116	interchain domain interface [polypeptide binding]; other site
1097677005117	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
1097677005118	Qo binding site; other site
1097677005119	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
1097677005120	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097677005121	S-adenosylmethionine binding site [chemical binding]; other site
1097677005122	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1097677005123	putative acetyltransferase; Provisional; Region: PRK03624
1097677005124	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097677005125	Coenzyme A binding pocket [chemical binding]; other site
1097677005126	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
1097677005127	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1097677005128	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1097677005129	D-pathway; other site
1097677005130	Putative ubiquinol binding site [chemical binding]; other site
1097677005131	Low-spin heme (heme b) binding site [chemical binding]; other site
1097677005132	Putative water exit pathway; other site
1097677005133	Binuclear center (heme o3/CuB) [ion binding]; other site
1097677005134	K-pathway; other site
1097677005135	Putative proton exit pathway; other site
1097677005136	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
1097677005137	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1097677005138	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1097677005139	hypothetical protein; Provisional; Region: PRK07907
1097677005140	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
1097677005141	active site
1097677005142	metal binding site [ion binding]; metal-binding site
1097677005143	dimer interface [polypeptide binding]; other site
1097677005144	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
1097677005145	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1097677005146	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1097677005147	quinone interaction residues [chemical binding]; other site
1097677005148	active site
1097677005149	catalytic residues [active]
1097677005150	FMN binding site [chemical binding]; other site
1097677005151	substrate binding site [chemical binding]; other site
1097677005152	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1097677005153	ATP cone domain; Region: ATP-cone; pfam03477
1097677005154	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1097677005155	histidinol dehydrogenase; Region: hisD; TIGR00069
1097677005156	NAD binding site [chemical binding]; other site
1097677005157	dimerization interface [polypeptide binding]; other site
1097677005158	product binding site; other site
1097677005159	substrate binding site [chemical binding]; other site
1097677005160	zinc binding site [ion binding]; other site
1097677005161	catalytic residues [active]
1097677005162	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1097677005163	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1097677005164	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
1097677005165	active site
1097677005166	PHP Thumb interface [polypeptide binding]; other site
1097677005167	metal binding site [ion binding]; metal-binding site
1097677005168	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1097677005169	generic binding surface II; other site
1097677005170	generic binding surface I; other site
1097677005171	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
1097677005172	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1097677005173	active site
1097677005174	Protein of unknown function (DUF552); Region: DUF552; pfam04472
1097677005175	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1097677005176	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1097677005177	catalytic residue [active]
1097677005178	cell division protein FtsZ; Validated; Region: PRK09330
1097677005179	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1097677005180	nucleotide binding site [chemical binding]; other site
1097677005181	SulA interaction site; other site
1097677005182	cell division protein FtsQ; Provisional; Region: PRK05529
1097677005183	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1097677005184	Cell division protein FtsQ; Region: FtsQ; pfam03799
1097677005185	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1097677005186	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1097677005187	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1097677005188	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1097677005189	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1097677005190	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1097677005191	active site
1097677005192	homodimer interface [polypeptide binding]; other site
1097677005193	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
1097677005194	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438
1097677005195	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1097677005196	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1097677005197	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1097677005198	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1097677005199	Mg++ binding site [ion binding]; other site
1097677005200	putative catalytic motif [active]
1097677005201	putative substrate binding site [chemical binding]; other site
1097677005202	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1097677005203	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1097677005204	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1097677005205	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1097677005206	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1097677005207	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1097677005208	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1097677005209	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1097677005210	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1097677005211	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1097677005212	MraW methylase family; Region: Methyltransf_5; cl17771
1097677005213	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1097677005214	cell division protein MraZ; Reviewed; Region: PRK00326
1097677005215	MraZ protein; Region: MraZ; pfam02381
1097677005216	MraZ protein; Region: MraZ; pfam02381
1097677005217	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
1097677005218	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
1097677005219	substrate binding pocket [chemical binding]; other site
1097677005220	aspartate-rich region 1; other site
1097677005221	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
1097677005222	substrate binding pocket [chemical binding]; other site
1097677005223	aspartate-rich region 2; other site
1097677005224	substrate-Mg2+ binding site; other site
1097677005225	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1097677005226	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1097677005227	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1097677005228	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1097677005229	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1097677005230	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1097677005231	active site
1097677005232	ATP binding site [chemical binding]; other site
1097677005233	substrate binding site [chemical binding]; other site
1097677005234	activation loop (A-loop); other site
1097677005235	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1097677005236	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1097677005237	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1097677005238	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1097677005239	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
1097677005240	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1097677005241	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1097677005242	putative acyl-acceptor binding pocket; other site
1097677005243	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1097677005244	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1097677005245	nucleotide binding site [chemical binding]; other site
1097677005246	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1097677005247	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1097677005248	acyl-activating enzyme (AAE) consensus motif; other site
1097677005249	putative AMP binding site [chemical binding]; other site
1097677005250	putative active site [active]
1097677005251	putative CoA binding site [chemical binding]; other site
1097677005252	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1097677005253	active site
1097677005254	catalytic residues [active]
1097677005255	metal binding site [ion binding]; metal-binding site
1097677005256	mycothione reductase; Reviewed; Region: PRK07846
1097677005257	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097677005258	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097677005259	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1097677005260	pyruvate carboxylase; Reviewed; Region: PRK12999
1097677005261	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1097677005262	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1097677005263	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1097677005264	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1097677005265	active site
1097677005266	catalytic residues [active]
1097677005267	metal binding site [ion binding]; metal-binding site
1097677005268	homodimer binding site [polypeptide binding]; other site
1097677005269	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1097677005270	carboxyltransferase (CT) interaction site; other site
1097677005271	biotinylation site [posttranslational modification]; other site
1097677005272	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1097677005273	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097677005274	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097677005275	Magnesium ion binding site [ion binding]; other site
1097677005276	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1097677005277	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1097677005278	DNA binding residues [nucleotide binding]
1097677005279	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1097677005280	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1097677005281	DNA binding residues [nucleotide binding]
1097677005282	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1097677005283	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1097677005284	phosphopeptide binding site; other site
1097677005285	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1097677005286	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1097677005287	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1097677005288	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097677005289	ATP binding site [chemical binding]; other site
1097677005290	Mg2+ binding site [ion binding]; other site
1097677005291	G-X-G motif; other site
1097677005292	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1097677005293	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677005294	active site
1097677005295	phosphorylation site [posttranslational modification]
1097677005296	intermolecular recognition site; other site
1097677005297	dimerization interface [polypeptide binding]; other site
1097677005298	FaeA-like protein; Region: FaeA; pfam04703
1097677005299	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1097677005300	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1097677005301	active site
1097677005302	Zn binding site [ion binding]; other site
1097677005303	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
1097677005304	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097677005305	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097677005306	DNA binding site [nucleotide binding]
1097677005307	domain linker motif; other site
1097677005308	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1097677005309	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1097677005310	hypothetical protein; Provisional; Region: PRK11622
1097677005311	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677005312	putative PBP binding loops; other site
1097677005313	dimer interface [polypeptide binding]; other site
1097677005314	ABC-ATPase subunit interface; other site
1097677005315	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097677005316	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677005317	dimer interface [polypeptide binding]; other site
1097677005318	conserved gate region; other site
1097677005319	putative PBP binding loops; other site
1097677005320	ABC-ATPase subunit interface; other site
1097677005321	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1097677005322	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677005323	Walker A/P-loop; other site
1097677005324	ATP binding site [chemical binding]; other site
1097677005325	Q-loop/lid; other site
1097677005326	ABC transporter signature motif; other site
1097677005327	Walker B; other site
1097677005328	D-loop; other site
1097677005329	H-loop/switch region; other site
1097677005330	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
1097677005331	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
1097677005332	active site
1097677005333	catalytic site [active]
1097677005334	metal binding site [ion binding]; metal-binding site
1097677005335	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
1097677005336	active site
1097677005337	NUDIX domain; Region: NUDIX; pfam00293
1097677005338	nudix motif; other site
1097677005339	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1097677005340	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1097677005341	putative NAD(P) binding site [chemical binding]; other site
1097677005342	amine oxidase; Region: PLN02976
1097677005343	probable polyamine oxidase; Region: PLN02268
1097677005344	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1097677005345	RNA binding surface [nucleotide binding]; other site
1097677005346	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1097677005347	HSP70 interaction site [polypeptide binding]; other site
1097677005348	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
1097677005349	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
1097677005350	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1097677005351	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1097677005352	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1097677005353	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1097677005354	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1097677005355	amino acid transporter; Region: 2A0306; TIGR00909
1097677005356	amino acid transporter; Region: 2A0306; TIGR00909
1097677005357	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1097677005358	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1097677005359	guanine deaminase; Provisional; Region: PRK09228
1097677005360	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097677005361	active site
1097677005362	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1097677005363	active site
1097677005364	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1097677005365	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1097677005366	Ligand binding site; other site
1097677005367	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1097677005368	active site
1097677005369	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
1097677005370	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1097677005371	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677005372	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097677005373	putative substrate translocation pore; other site
1097677005374	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1097677005375	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1097677005376	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
1097677005377	active site
1097677005378	catalytic triad [active]
1097677005379	oxyanion hole [active]
1097677005380	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
1097677005381	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1097677005382	Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
1097677005383	NAD(P) binding site [chemical binding]; other site
1097677005385	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
1097677005386	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1097677005387	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097677005388	acyl-activating enzyme (AAE) consensus motif; other site
1097677005389	AMP binding site [chemical binding]; other site
1097677005390	active site
1097677005391	CoA binding site [chemical binding]; other site
1097677005392	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097677005393	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1097677005394	TAP-like protein; Region: Abhydrolase_4; pfam08386
1097677005395	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097677005396	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097677005397	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1097677005398	active site
1097677005399	8-oxo-dGMP binding site [chemical binding]; other site
1097677005400	nudix motif; other site
1097677005401	metal binding site [ion binding]; metal-binding site
1097677005402	Cmm homolog CMM_1936; Cms homologs CMS_0983 and CMS_1687
1097677005403	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1097677005404	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097677005405	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1097677005406	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
1097677005407	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1097677005408	metal binding site [ion binding]; metal-binding site
1097677005409	putative dimer interface [polypeptide binding]; other site
1097677005410	Predicted membrane protein [Function unknown]; Region: COG4270
1097677005411	Protein of unknown function (DUF664); Region: DUF664; pfam04978
1097677005412	DinB superfamily; Region: DinB_2; pfam12867
1097677005413	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097677005414	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1097677005415	active site
1097677005416	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1097677005417	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1097677005418	active site
1097677005419	non-prolyl cis peptide bond; other site
1097677005420	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677005421	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097677005422	putative substrate translocation pore; other site
1097677005423	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1097677005424	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097677005425	Coenzyme A binding pocket [chemical binding]; other site
1097677005426	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1097677005427	AAA domain; Region: AAA_12; pfam13087
1097677005428	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
1097677005429	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1097677005430	Phosphotransferase enzyme family; Region: APH; pfam01636
1097677005431	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
1097677005432	RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885
1097677005433	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1097677005434	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097677005435	active site
1097677005436	GTP-binding protein Der; Reviewed; Region: PRK03003
1097677005437	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1097677005438	G1 box; other site
1097677005439	GTP/Mg2+ binding site [chemical binding]; other site
1097677005440	Switch I region; other site
1097677005441	G2 box; other site
1097677005442	Switch II region; other site
1097677005443	G3 box; other site
1097677005444	G4 box; other site
1097677005445	G5 box; other site
1097677005446	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1097677005447	G1 box; other site
1097677005448	GTP/Mg2+ binding site [chemical binding]; other site
1097677005449	Switch I region; other site
1097677005450	G2 box; other site
1097677005451	G3 box; other site
1097677005452	Switch II region; other site
1097677005453	G4 box; other site
1097677005454	G5 box; other site
1097677005455	cytidylate kinase; Provisional; Region: cmk; PRK00023
1097677005456	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1097677005457	CMP-binding site; other site
1097677005458	The sites determining sugar specificity; other site
1097677005459	prephenate dehydrogenase; Validated; Region: PRK06545
1097677005460	prephenate dehydrogenase; Validated; Region: PRK08507
1097677005461	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1097677005462	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1097677005463	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1097677005464	RNA binding surface [nucleotide binding]; other site
1097677005465	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1097677005466	active site
1097677005467	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
1097677005468	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1097677005469	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1097677005470	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097677005471	P-loop; other site
1097677005472	Magnesium ion binding site [ion binding]; other site
1097677005473	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097677005474	Magnesium ion binding site [ion binding]; other site
1097677005475	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1097677005476	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1097677005477	active site
1097677005478	Int/Topo IB signature motif; other site
1097677005479	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1097677005480	dimer interface [polypeptide binding]; other site
1097677005481	ADP-ribose binding site [chemical binding]; other site
1097677005482	active site
1097677005483	nudix motif; other site
1097677005484	metal binding site [ion binding]; metal-binding site
1097677005485	CTP synthetase; Validated; Region: pyrG; PRK05380
1097677005486	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1097677005487	Catalytic site [active]
1097677005488	active site
1097677005489	UTP binding site [chemical binding]; other site
1097677005490	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1097677005491	active site
1097677005492	putative oxyanion hole; other site
1097677005493	catalytic triad [active]
1097677005494	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1097677005495	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677005496	Walker A/P-loop; other site
1097677005497	ATP binding site [chemical binding]; other site
1097677005498	Q-loop/lid; other site
1097677005499	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677005500	ABC transporter signature motif; other site
1097677005501	Walker B; other site
1097677005502	D-loop; other site
1097677005503	H-loop/switch region; other site
1097677005504	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
1097677005505	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
1097677005506	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1097677005507	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1097677005508	RNA binding surface [nucleotide binding]; other site
1097677005509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097677005510	S-adenosylmethionine binding site [chemical binding]; other site
1097677005511	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1097677005512	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097677005513	active site
1097677005514	motif I; other site
1097677005515	motif II; other site
1097677005516	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097677005517	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1097677005518	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1097677005519	active site
1097677005520	HIGH motif; other site
1097677005521	dimer interface [polypeptide binding]; other site
1097677005522	KMSKS motif; other site
1097677005523	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1097677005524	active site
1097677005525	DNA binding site [nucleotide binding]
1097677005526	argininosuccinate lyase; Provisional; Region: PRK00855
1097677005527	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1097677005528	active sites [active]
1097677005529	tetramer interface [polypeptide binding]; other site
1097677005530	argininosuccinate synthase; Provisional; Region: PRK13820
1097677005531	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1097677005532	ANP binding site [chemical binding]; other site
1097677005533	Substrate Binding Site II [chemical binding]; other site
1097677005534	Substrate Binding Site I [chemical binding]; other site
1097677005535	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1097677005536	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1097677005537	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1097677005538	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
1097677005539	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1097677005540	inhibitor-cofactor binding pocket; inhibition site
1097677005541	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677005542	catalytic residue [active]
1097677005543	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1097677005544	feedback inhibition sensing region; other site
1097677005545	homohexameric interface [polypeptide binding]; other site
1097677005546	nucleotide binding site [chemical binding]; other site
1097677005547	N-acetyl-L-glutamate binding site [chemical binding]; other site
1097677005548	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1097677005549	heterotetramer interface [polypeptide binding]; other site
1097677005550	active site pocket [active]
1097677005551	cleavage site
1097677005552	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1097677005553	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1097677005554	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1097677005555	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1097677005556	putative tRNA-binding site [nucleotide binding]; other site
1097677005557	B3/4 domain; Region: B3_4; pfam03483
1097677005558	tRNA synthetase B5 domain; Region: B5; smart00874
1097677005559	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1097677005560	dimer interface [polypeptide binding]; other site
1097677005561	motif 1; other site
1097677005562	motif 3; other site
1097677005563	motif 2; other site
1097677005564	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1097677005565	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1097677005566	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1097677005567	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1097677005568	dimer interface [polypeptide binding]; other site
1097677005569	motif 1; other site
1097677005570	active site
1097677005571	motif 2; other site
1097677005572	motif 3; other site
1097677005573	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677005574	dimer interface [polypeptide binding]; other site
1097677005575	conserved gate region; other site
1097677005576	putative PBP binding loops; other site
1097677005577	ABC-ATPase subunit interface; other site
1097677005578	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677005579	dimer interface [polypeptide binding]; other site
1097677005580	conserved gate region; other site
1097677005581	putative PBP binding loops; other site
1097677005582	ABC-ATPase subunit interface; other site
1097677005583	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097677005584	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1097677005585	substrate binding pocket [chemical binding]; other site
1097677005586	membrane-bound complex binding site; other site
1097677005587	hinge residues; other site
1097677005588	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1097677005589	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1097677005590	Walker A/P-loop; other site
1097677005591	ATP binding site [chemical binding]; other site
1097677005592	Q-loop/lid; other site
1097677005593	ABC transporter signature motif; other site
1097677005594	Walker B; other site
1097677005595	D-loop; other site
1097677005596	H-loop/switch region; other site
1097677005597	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1097677005598	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1097677005599	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1097677005600	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1097677005601	23S rRNA binding site [nucleotide binding]; other site
1097677005602	L21 binding site [polypeptide binding]; other site
1097677005603	L13 binding site [polypeptide binding]; other site
1097677005604	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1097677005605	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1097677005606	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1097677005607	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1097677005608	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1097677005609	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1097677005610	catalytic residues [active]
1097677005611	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
1097677005612	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1097677005613	putative active site [active]
1097677005614	oxyanion strand; other site
1097677005615	catalytic triad [active]
1097677005616	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1097677005617	putative active site pocket [active]
1097677005618	4-fold oligomerization interface [polypeptide binding]; other site
1097677005619	metal binding residues [ion binding]; metal-binding site
1097677005620	3-fold/trimer interface [polypeptide binding]; other site
1097677005621	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
1097677005622	LexA repressor; Validated; Region: PRK00215
1097677005623	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1097677005624	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1097677005625	Catalytic site [active]
1097677005626	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1097677005627	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1097677005628	HflX GTPase family; Region: HflX; cd01878
1097677005629	G1 box; other site
1097677005630	GTP/Mg2+ binding site [chemical binding]; other site
1097677005631	Switch I region; other site
1097677005632	G2 box; other site
1097677005633	G3 box; other site
1097677005634	Switch II region; other site
1097677005635	G4 box; other site
1097677005636	G5 box; other site
1097677005637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097677005638	S-adenosylmethionine binding site [chemical binding]; other site
1097677005639	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1097677005640	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1097677005641	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1097677005642	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1097677005643	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1097677005644	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
1097677005645	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1097677005646	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097677005647	FeS/SAM binding site; other site
1097677005648	TRAM domain; Region: TRAM; cl01282
1097677005649	RecX family; Region: RecX; pfam02631
1097677005650	recombinase A; Provisional; Region: recA; PRK09354
1097677005651	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1097677005652	hexamer interface [polypeptide binding]; other site
1097677005653	Walker A motif; other site
1097677005654	ATP binding site [chemical binding]; other site
1097677005655	Walker B motif; other site
1097677005656	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
1097677005657	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097677005658	non-specific DNA binding site [nucleotide binding]; other site
1097677005659	salt bridge; other site
1097677005660	sequence-specific DNA binding site [nucleotide binding]; other site
1097677005661	Competence-damaged protein; Region: CinA; pfam02464
1097677005662	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1097677005663	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1097677005664	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1097677005665	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1097677005666	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1097677005667	FtsX-like permease family; Region: FtsX; pfam02687
1097677005668	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1097677005669	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1097677005670	Walker A/P-loop; other site
1097677005671	ATP binding site [chemical binding]; other site
1097677005672	Q-loop/lid; other site
1097677005673	ABC transporter signature motif; other site
1097677005674	Walker B; other site
1097677005675	D-loop; other site
1097677005676	H-loop/switch region; other site
1097677005677	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1097677005678	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1097677005679	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097677005680	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1097677005681	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1097677005682	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1097677005683	dimer interface [polypeptide binding]; other site
1097677005684	active site
1097677005685	catalytic residue [active]
1097677005686	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
1097677005687	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677005688	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1097677005689	NAD(P) binding site [chemical binding]; other site
1097677005690	active site
1097677005691	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1097677005692	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1097677005693	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1097677005694	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1097677005695	catalytic core [active]
1097677005696	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1097677005697	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1097677005698	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1097677005699	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097677005700	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097677005701	active site
1097677005702	catalytic tetrad [active]
1097677005703	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1097677005704	substrate binding site [chemical binding]; other site
1097677005705	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
1097677005706	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
1097677005707	oligomer interface [polypeptide binding]; other site
1097677005708	RNA binding site [nucleotide binding]; other site
1097677005709	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1097677005710	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1097677005711	RNase E interface [polypeptide binding]; other site
1097677005712	trimer interface [polypeptide binding]; other site
1097677005713	active site
1097677005714	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1097677005715	putative nucleic acid binding region [nucleotide binding]; other site
1097677005716	G-X-X-G motif; other site
1097677005717	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1097677005718	RNA binding site [nucleotide binding]; other site
1097677005719	domain interface; other site
1097677005720	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1097677005721	16S/18S rRNA binding site [nucleotide binding]; other site
1097677005722	S13e-L30e interaction site [polypeptide binding]; other site
1097677005723	25S rRNA binding site [nucleotide binding]; other site
1097677005724	enterobactin exporter EntS; Provisional; Region: PRK10489
1097677005725	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1097677005726	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1097677005727	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1097677005728	transmembrane helices; other site
1097677005729	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1097677005730	Part of AAA domain; Region: AAA_19; pfam13245
1097677005731	Family description; Region: UvrD_C_2; pfam13538
1097677005732	VanZ like family; Region: VanZ; pfam04892
1097677005733	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1097677005734	substrate binding site [chemical binding]; other site
1097677005735	THF binding site; other site
1097677005736	zinc-binding site [ion binding]; other site
1097677005737	adenine phosphoribosyltransferase; Provisional; Region: PRK02304
1097677005738	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
1097677005739	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097677005740	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097677005741	active site
1097677005742	catalytic tetrad [active]
1097677005743	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
1097677005744	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1097677005745	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1097677005746	proposed catalytic triad [active]
1097677005747	conserved cys residue [active]
1097677005748	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1097677005749	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1097677005750	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1097677005751	dimerization interface [polypeptide binding]; other site
1097677005752	DPS ferroxidase diiron center [ion binding]; other site
1097677005753	ion pore; other site
1097677005754	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097677005755	classical (c) SDRs; Region: SDR_c; cd05233
1097677005756	NAD(P) binding site [chemical binding]; other site
1097677005757	active site
1097677005758	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
1097677005759	Histidine kinase; Region: HisKA_3; pfam07730
1097677005760	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1097677005761	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097677005762	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677005763	active site
1097677005764	phosphorylation site [posttranslational modification]
1097677005765	intermolecular recognition site; other site
1097677005766	dimerization interface [polypeptide binding]; other site
1097677005767	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097677005768	DNA binding residues [nucleotide binding]
1097677005769	dimerization interface [polypeptide binding]; other site
1097677005770	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1097677005771	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
1097677005772	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1097677005773	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1097677005774	catalytic residues [active]
1097677005775	catalytic nucleophile [active]
1097677005776	Protein of unknown function (DUF3072); Region: DUF3072; pfam11272
1097677005777	Protease prsW family; Region: PrsW-protease; pfam13367
1097677005778	FAD binding domain; Region: FAD_binding_4; pfam01565
1097677005779	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1097677005780	AlkA N-terminal domain; Region: AlkA_N; cl05528
1097677005781	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1097677005782	endonuclease III; Region: ENDO3c; smart00478
1097677005783	minor groove reading motif; other site
1097677005784	helix-hairpin-helix signature motif; other site
1097677005785	substrate binding pocket [chemical binding]; other site
1097677005786	active site
1097677005787	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1097677005788	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1097677005789	putative DNA binding site [nucleotide binding]; other site
1097677005790	putative homodimer interface [polypeptide binding]; other site
1097677005791	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
1097677005792	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
1097677005793	nucleotide binding site [chemical binding]; other site
1097677005794	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
1097677005795	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1097677005796	active site
1097677005797	DNA binding site [nucleotide binding]
1097677005798	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1097677005799	DNA binding site [nucleotide binding]
1097677005800	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1097677005801	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1097677005802	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1097677005803	Aspartase; Region: Aspartase; cd01357
1097677005804	active sites [active]
1097677005805	tetramer interface [polypeptide binding]; other site
1097677005806	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
1097677005807	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
1097677005808	Ligand binding site; other site
1097677005809	Putative Catalytic site; other site
1097677005810	DXD motif; other site
1097677005811	Predicted membrane protein [Function unknown]; Region: COG2246
1097677005812	GtrA-like protein; Region: GtrA; pfam04138
1097677005813	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1097677005814	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1097677005815	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1097677005816	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1097677005817	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1097677005818	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1097677005819	substrate binding pocket [chemical binding]; other site
1097677005820	catalytic triad [active]
1097677005821	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
1097677005822	putative active site; other site
1097677005823	putative metal binding residues [ion binding]; other site
1097677005824	signature motif; other site
1097677005825	putative triphosphate binding site [ion binding]; other site
1097677005826	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
1097677005827	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1097677005828	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1097677005829	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1097677005830	NAD(P) binding site [chemical binding]; other site
1097677005831	substrate binding site [chemical binding]; other site
1097677005832	dimer interface [polypeptide binding]; other site
1097677005833	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677005834	NmrA-like family; Region: NmrA; pfam05368
1097677005835	NAD(P) binding site [chemical binding]; other site
1097677005836	active site
1097677005837	Cmm ortholog; Cms ortholog CMS_1139
1097677005838	short chain dehydrogenase; Provisional; Region: PRK08219
1097677005839	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677005840	NAD(P) binding site [chemical binding]; other site
1097677005841	active site
1097677005842	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1097677005843	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1097677005844	putative dimer interface [polypeptide binding]; other site
1097677005845	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
1097677005846	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1097677005847	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1097677005848	IucA / IucC family; Region: IucA_IucC; pfam04183
1097677005849	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1097677005850	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
1097677005851	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097677005852	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
1097677005853	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677005854	catalytic residue [active]
1097677005855	oxidoreductase; Provisional; Region: PRK06128
1097677005856	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1097677005857	NAD binding site [chemical binding]; other site
1097677005858	metal binding site [ion binding]; metal-binding site
1097677005859	active site
1097677005860	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1097677005861	iron-sulfur cluster [ion binding]; other site
1097677005862	[2Fe-2S] cluster binding site [ion binding]; other site
1097677005863	H+ Antiporter protein; Region: 2A0121; TIGR00900
1097677005864	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677005865	putative substrate translocation pore; other site
1097677005866	SPFH domain / Band 7 family; Region: Band_7; pfam01145
1097677005867	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1097677005868	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1097677005869	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677005870	dimer interface [polypeptide binding]; other site
1097677005871	conserved gate region; other site
1097677005872	putative PBP binding loops; other site
1097677005873	ABC-ATPase subunit interface; other site
1097677005874	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097677005875	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677005876	dimer interface [polypeptide binding]; other site
1097677005877	conserved gate region; other site
1097677005878	putative PBP binding loops; other site
1097677005879	ABC-ATPase subunit interface; other site
1097677005880	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1097677005881	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
1097677005882	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1097677005883	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
1097677005884	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
1097677005885	FAD binding domain; Region: FAD_binding_4; pfam01565
1097677005886	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1097677005887	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1097677005888	catalytic residues [active]
1097677005889	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
1097677005890	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
1097677005891	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097677005892	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1097677005893	substrate binding site [chemical binding]; other site
1097677005894	multimerization interface [polypeptide binding]; other site
1097677005895	ATP binding site [chemical binding]; other site
1097677005896	multifunctional thiamine-phosphate pyrophosphorylase/synthase/phosphomethylpyrimidine kinase; Provisional; Region: PRK09517
1097677005897	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1097677005898	pyrophosphate binding site [ion binding]; other site
1097677005899	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1097677005900	dimer interface [polypeptide binding]; other site
1097677005901	substrate binding site [chemical binding]; other site
1097677005902	ATP binding site [chemical binding]; other site
1097677005903	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
1097677005904	Cupin domain; Region: Cupin_2; cl17218
1097677005905	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677005906	putative substrate translocation pore; other site
1097677005907	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097677005908	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677005909	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
1097677005910	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1097677005911	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097677005912	ATP binding site [chemical binding]; other site
1097677005913	putative Mg++ binding site [ion binding]; other site
1097677005914	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097677005915	nucleotide binding region [chemical binding]; other site
1097677005916	ATP-binding site [chemical binding]; other site
1097677005917	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1097677005918	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1097677005919	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1097677005920	putative dimer interface [polypeptide binding]; other site
1097677005921	N-terminal domain interface [polypeptide binding]; other site
1097677005922	putative substrate binding pocket (H-site) [chemical binding]; other site
1097677005923	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1097677005924	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260
1097677005925	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1097677005926	putative NAD(P) binding site [chemical binding]; other site
1097677005927	catalytic Zn binding site [ion binding]; other site
1097677005928	structural Zn binding site [ion binding]; other site
1097677005929	no orthologs in Cmm and Cms
1097677005930	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1097677005931	pyruvate dehydrogenase; Provisional; Region: PRK06546
1097677005932	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1097677005933	PYR/PP interface [polypeptide binding]; other site
1097677005934	tetramer interface [polypeptide binding]; other site
1097677005935	dimer interface [polypeptide binding]; other site
1097677005936	TPP binding site [chemical binding]; other site
1097677005937	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097677005938	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1097677005939	TPP-binding site [chemical binding]; other site
1097677005940	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
1097677005941	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097677005942	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1097677005943	active site
1097677005944	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1097677005945	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097677005946	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677005947	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1097677005948	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1097677005949	active site
1097677005950	catalytic triad [active]
1097677005951	oxyanion hole [active]
1097677005952	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
1097677005953	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1097677005954	putative NAD(P) binding site [chemical binding]; other site
1097677005955	putative active site [active]
1097677005956	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
1097677005957	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1097677005958	putative hydrophobic ligand binding site [chemical binding]; other site
1097677005959	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1097677005960	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1097677005961	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1097677005962	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1097677005963	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1097677005964	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1097677005965	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1097677005966	active site
1097677005967	Riboflavin kinase; Region: Flavokinase; smart00904
1097677005968	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
1097677005969	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1097677005970	RNA binding site [nucleotide binding]; other site
1097677005971	active site
1097677005972	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
1097677005973	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
1097677005974	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1097677005975	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1097677005976	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1097677005977	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1097677005978	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1097677005979	minor groove reading motif; other site
1097677005980	helix-hairpin-helix signature motif; other site
1097677005981	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1097677005982	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1097677005983	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1097677005984	translation initiation factor IF-2; Region: IF-2; TIGR00487
1097677005985	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1097677005986	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1097677005987	G1 box; other site
1097677005988	putative GEF interaction site [polypeptide binding]; other site
1097677005989	GTP/Mg2+ binding site [chemical binding]; other site
1097677005990	Switch I region; other site
1097677005991	G2 box; other site
1097677005992	G3 box; other site
1097677005993	Switch II region; other site
1097677005994	G4 box; other site
1097677005995	G5 box; other site
1097677005996	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1097677005997	Translation-initiation factor 2; Region: IF-2; pfam11987
1097677005998	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1097677005999	Protein of unknown function (DUF448); Region: DUF448; pfam04296
1097677006000	putative RNA binding cleft [nucleotide binding]; other site
1097677006001	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1097677006002	NusA N-terminal domain; Region: NusA_N; pfam08529
1097677006003	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1097677006004	RNA binding site [nucleotide binding]; other site
1097677006005	homodimer interface [polypeptide binding]; other site
1097677006006	NusA-like KH domain; Region: KH_5; pfam13184
1097677006007	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1097677006008	G-X-X-G motif; other site
1097677006009	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1097677006010	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1097677006011	dimer interface [polypeptide binding]; other site
1097677006012	motif 1; other site
1097677006013	active site
1097677006014	motif 2; other site
1097677006015	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1097677006016	putative deacylase active site [active]
1097677006017	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1097677006018	active site
1097677006019	motif 3; other site
1097677006020	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1097677006021	anticodon binding site; other site
1097677006022	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097677006023	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677006024	NAD(P) binding site [chemical binding]; other site
1097677006025	active site
1097677006026	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097677006027	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097677006028	acyl-activating enzyme (AAE) consensus motif; other site
1097677006029	AMP binding site [chemical binding]; other site
1097677006030	active site
1097677006031	CoA binding site [chemical binding]; other site
1097677006032	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
1097677006033	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1097677006034	active site
1097677006035	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1097677006036	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1097677006037	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1097677006038	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1097677006039	active site
1097677006040	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1097677006041	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
1097677006042	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1097677006043	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1097677006044	putative substrate binding region [chemical binding]; other site
1097677006045	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1097677006046	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1097677006047	active site
1097677006048	ATP binding site [chemical binding]; other site
1097677006049	substrate binding site [chemical binding]; other site
1097677006050	activation loop (A-loop); other site
1097677006051	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1097677006052	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1097677006053	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1097677006054	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1097677006055	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1097677006056	OsmC-like protein; Region: OsmC; cl00767
1097677006057	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
1097677006058	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1097677006059	inhibitor-cofactor binding pocket; inhibition site
1097677006060	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677006061	catalytic residue [active]
1097677006062	L-asparaginase II; Region: Asparaginase_II; pfam06089
1097677006063	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1097677006064	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1097677006065	Protein of unknown function DUF58; Region: DUF58; pfam01882
1097677006066	MoxR-like ATPases [General function prediction only]; Region: COG0714
1097677006067	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097677006068	Walker A motif; other site
1097677006069	ATP binding site [chemical binding]; other site
1097677006070	Walker B motif; other site
1097677006071	arginine finger; other site
1097677006072	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1097677006073	Interdomain contacts; other site
1097677006074	Cytokine receptor motif; other site
1097677006075	Cmm ortholog CMM_2170; Cms ortholog CMS_2201/2202 (pseudogene)
1097677006076	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1097677006077	dimer interface [polypeptide binding]; other site
1097677006078	Citrate synthase; Region: Citrate_synt; pfam00285
1097677006079	active site
1097677006080	citrylCoA binding site [chemical binding]; other site
1097677006081	NADH binding [chemical binding]; other site
1097677006082	cationic pore residues; other site
1097677006083	oxalacetate/citrate binding site [chemical binding]; other site
1097677006084	coenzyme A binding site [chemical binding]; other site
1097677006085	catalytic triad [active]
1097677006086	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
1097677006087	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097677006088	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677006089	homodimer interface [polypeptide binding]; other site
1097677006090	catalytic residue [active]
1097677006091	Ferredoxin [Energy production and conversion]; Region: COG1146
1097677006092	4Fe-4S binding domain; Region: Fer4; pfam00037
1097677006093	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
1097677006094	Iron permease FTR1 family; Region: FTR1; pfam03239
1097677006095	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
1097677006096	Imelysin; Region: Peptidase_M75; pfam09375
1097677006097	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
1097677006098	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1097677006099	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
1097677006100	G1 box; other site
1097677006101	putative GEF interaction site [polypeptide binding]; other site
1097677006102	GTP/Mg2+ binding site [chemical binding]; other site
1097677006103	Switch I region; other site
1097677006104	G2 box; other site
1097677006105	G3 box; other site
1097677006106	Switch II region; other site
1097677006107	G4 box; other site
1097677006108	G5 box; other site
1097677006109	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1097677006110	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1097677006111	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
1097677006112	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1097677006113	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1097677006114	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097677006115	Walker A/P-loop; other site
1097677006116	ATP binding site [chemical binding]; other site
1097677006117	Q-loop/lid; other site
1097677006118	ABC transporter signature motif; other site
1097677006119	Walker B; other site
1097677006120	D-loop; other site
1097677006121	H-loop/switch region; other site
1097677006122	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1097677006123	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097677006124	Walker A/P-loop; other site
1097677006125	ATP binding site [chemical binding]; other site
1097677006126	Q-loop/lid; other site
1097677006127	ABC transporter signature motif; other site
1097677006128	Walker B; other site
1097677006129	D-loop; other site
1097677006130	H-loop/switch region; other site
1097677006131	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1097677006132	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1097677006133	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1097677006134	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677006135	ABC-ATPase subunit interface; other site
1097677006136	putative PBP binding loops; other site
1097677006137	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1097677006138	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1097677006139	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1097677006140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677006141	putative PBP binding loops; other site
1097677006142	dimer interface [polypeptide binding]; other site
1097677006143	ABC-ATPase subunit interface; other site
1097677006144	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1097677006145	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
1097677006146	CAAX protease self-immunity; Region: Abi; pfam02517
1097677006147	Protein of unknown function, DUF485; Region: DUF485; pfam04341
1097677006148	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1097677006149	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1097677006150	Na binding site [ion binding]; other site
1097677006151	glycine dehydrogenase; Provisional; Region: PRK05367
1097677006152	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1097677006153	tetramer interface [polypeptide binding]; other site
1097677006154	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677006155	catalytic residue [active]
1097677006156	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1097677006157	tetramer interface [polypeptide binding]; other site
1097677006158	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677006159	catalytic residue [active]
1097677006160	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1097677006161	lipoyl attachment site [posttranslational modification]; other site
1097677006162	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1097677006163	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1097677006164	Penicillinase repressor; Region: Pencillinase_R; cl17580
1097677006165	CopC domain; Region: CopC; pfam04234
1097677006166	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1097677006167	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1097677006168	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097677006169	catalytic residue [active]
1097677006170	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1097677006171	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1097677006172	trimerization site [polypeptide binding]; other site
1097677006173	active site
1097677006174	ChaB; Region: ChaB; pfam06150
1097677006175	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
1097677006176	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1097677006177	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1097677006178	T5orf172 domain; Region: T5orf172; pfam10544
1097677006179	Amino acid permease; Region: AA_permease_2; pfam13520
1097677006180	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097677006181	Ligand Binding Site [chemical binding]; other site
1097677006182	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1097677006183	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1097677006184	active site
1097677006185	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1097677006186	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1097677006187	catalytic residues [active]
1097677006188	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1097677006189	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1097677006190	catalytic core [active]
1097677006191	Protein of unknown function (DUF3090); Region: DUF3090; pfam11290
1097677006192	conserved hypothetical protein; Region: TIGR03843
1097677006193	Protein of unknown function DUF262; Region: DUF262; pfam03235
1097677006194	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1097677006195	Protein of unknown function DUF262; Region: DUF262; pfam03235
1097677006196	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1097677006197	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1097677006198	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1097677006199	catalytic residues [active]
1097677006200	catalytic nucleophile [active]
1097677006201	Recombinase; Region: Recombinase; pfam07508
1097677006202	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1097677006203	DNA methylase; Region: N6_N4_Mtase; pfam01555
1097677006204	DNA methylase; Region: N6_N4_Mtase; cl17433
1097677006205	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
1097677006206	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097677006207	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1097677006208	Walker A motif; other site
1097677006209	ATP binding site [chemical binding]; other site
1097677006210	Walker B motif; other site
1097677006211	arginine finger; other site
1097677006212	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1097677006213	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1097677006214	catalytic residues [active]
1097677006215	catalytic nucleophile [active]
1097677006216	AAA domain; Region: AAA_25; pfam13481
1097677006217	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1097677006218	Walker A motif; other site
1097677006219	ATP binding site [chemical binding]; other site
1097677006220	Walker B motif; other site
1097677006221	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
1097677006222	polymerase nucleotide-binding site; other site
1097677006223	DNA-binding residues [nucleotide binding]; DNA binding site
1097677006224	nucleotide binding site [chemical binding]; other site
1097677006225	primase nucleotide-binding site [nucleotide binding]; other site
1097677006226	GTP-binding protein YchF; Reviewed; Region: PRK09601
1097677006227	YchF GTPase; Region: YchF; cd01900
1097677006228	G1 box; other site
1097677006229	GTP/Mg2+ binding site [chemical binding]; other site
1097677006230	Switch I region; other site
1097677006231	G2 box; other site
1097677006232	Switch II region; other site
1097677006233	G3 box; other site
1097677006234	G4 box; other site
1097677006235	G5 box; other site
1097677006236	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1097677006237	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1097677006238	active site
1097677006239	catalytic site [active]
1097677006240	substrate binding site [chemical binding]; other site
1097677006241	RmuC family; Region: RmuC; pfam02646
1097677006242	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1097677006243	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
1097677006244	active site
1097677006245	intersubunit interface [polypeptide binding]; other site
1097677006246	zinc binding site [ion binding]; other site
1097677006247	Na+ binding site [ion binding]; other site
1097677006248	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1097677006249	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1097677006250	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1097677006251	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1097677006252	generic binding surface II; other site
1097677006253	generic binding surface I; other site
1097677006254	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1097677006255	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
1097677006256	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
1097677006257	active site clefts [active]
1097677006258	zinc binding site [ion binding]; other site
1097677006259	dimer interface [polypeptide binding]; other site
1097677006260	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1097677006261	Class II fumarases; Region: Fumarase_classII; cd01362
1097677006262	active site
1097677006263	tetramer interface [polypeptide binding]; other site
1097677006264	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1097677006265	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1097677006266	putative active site [active]
1097677006267	PhoH-like protein; Region: PhoH; pfam02562
1097677006268	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1097677006269	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
1097677006270	catalytic residue [active]
1097677006271	putative FPP diphosphate  binding site; other site
1097677006272	putative FPP binding hydrophobic cleft; other site
1097677006273	dimer interface [polypeptide binding]; other site
1097677006274	putative IPP diphosphate binding site; other site
1097677006275	Haemolysin-III related; Region: HlyIII; pfam03006
1097677006276	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1097677006277	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1097677006278	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097677006279	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677006280	dimer interface [polypeptide binding]; other site
1097677006281	conserved gate region; other site
1097677006282	putative PBP binding loops; other site
1097677006283	ABC-ATPase subunit interface; other site
1097677006284	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677006285	dimer interface [polypeptide binding]; other site
1097677006286	conserved gate region; other site
1097677006287	putative PBP binding loops; other site
1097677006288	ABC-ATPase subunit interface; other site
1097677006289	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
1097677006290	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
1097677006291	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1097677006292	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1097677006293	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1097677006294	threonine dehydratase; Provisional; Region: PRK08198
1097677006295	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1097677006296	tetramer interface [polypeptide binding]; other site
1097677006297	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677006298	catalytic residue [active]
1097677006299	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
1097677006300	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1097677006301	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1097677006302	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
1097677006303	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1097677006304	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
1097677006305	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1097677006306	beta-galactosidase; Region: BGL; TIGR03356
1097677006307	amino acid transporter; Region: 2A0306; TIGR00909
1097677006308	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1097677006309	Ferritin-like domain; Region: Ferritin_2; pfam13668
1097677006310	OpgC protein; Region: OpgC_C; pfam10129
1097677006311	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1097677006312	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1097677006313	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1097677006314	anti sigma factor interaction site; other site
1097677006315	regulatory phosphorylation site [posttranslational modification]; other site
1097677006316	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097677006317	active site
1097677006318	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097677006319	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1097677006320	GAF domain; Region: GAF; pfam01590
1097677006321	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1097677006322	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1097677006323	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1097677006324	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1097677006325	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097677006326	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1097677006327	active site
1097677006328	catalytic residues [active]
1097677006329	Protein of unknown function (DUF501); Region: DUF501; pfam04417
1097677006330	Septum formation initiator; Region: DivIC; cl17659
1097677006331	enolase; Provisional; Region: eno; PRK00077
1097677006332	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1097677006333	dimer interface [polypeptide binding]; other site
1097677006334	metal binding site [ion binding]; metal-binding site
1097677006335	substrate binding pocket [chemical binding]; other site
1097677006336	histidyl-tRNA synthetase; Region: hisS; TIGR00442
1097677006337	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1097677006338	dimer interface [polypeptide binding]; other site
1097677006339	motif 1; other site
1097677006340	active site
1097677006341	motif 2; other site
1097677006342	motif 3; other site
1097677006343	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097677006344	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1097677006345	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
1097677006346	homodimer interface [polypeptide binding]; other site
1097677006347	metal binding site [ion binding]; metal-binding site
1097677006348	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
1097677006349	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1097677006350	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1097677006351	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097677006352	ATP binding site [chemical binding]; other site
1097677006353	putative Mg++ binding site [ion binding]; other site
1097677006354	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097677006355	nucleotide binding region [chemical binding]; other site
1097677006356	ATP-binding site [chemical binding]; other site
1097677006357	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1097677006358	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1097677006359	putative active site [active]
1097677006360	catalytic residue [active]
1097677006361	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1097677006362	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1097677006363	5S rRNA interface [nucleotide binding]; other site
1097677006364	CTC domain interface [polypeptide binding]; other site
1097677006365	L16 interface [polypeptide binding]; other site
1097677006366	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1097677006367	AAA domain; Region: AAA_33; pfam13671
1097677006368	ATP-binding site [chemical binding]; other site
1097677006369	Gluconate-6-phosphate binding site [chemical binding]; other site
1097677006370	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097677006371	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097677006372	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1097677006373	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1097677006374	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1097677006375	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1097677006376	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1097677006377	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
1097677006378	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1097677006379	active site
1097677006380	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
1097677006381	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1097677006382	Substrate binding site; other site
1097677006383	Mg++ binding site; other site
1097677006384	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1097677006385	active site
1097677006386	substrate binding site [chemical binding]; other site
1097677006387	CoA binding site [chemical binding]; other site
1097677006388	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097677006389	MarR family; Region: MarR_2; pfam12802
1097677006390	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
1097677006391	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1097677006392	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1097677006393	Lysine efflux permease [General function prediction only]; Region: COG1279
1097677006394	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1097677006395	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097677006396	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097677006397	dimerization interface [polypeptide binding]; other site
1097677006398	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677006399	dimer interface [polypeptide binding]; other site
1097677006400	conserved gate region; other site
1097677006401	ABC-ATPase subunit interface; other site
1097677006402	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1097677006403	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1097677006404	Walker A/P-loop; other site
1097677006405	ATP binding site [chemical binding]; other site
1097677006406	Q-loop/lid; other site
1097677006407	ABC transporter signature motif; other site
1097677006408	Walker B; other site
1097677006409	D-loop; other site
1097677006410	H-loop/switch region; other site
1097677006411	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1097677006412	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1097677006413	Cmm ortholog CMM_2284; Cms ortholog CMS_2480
1097677006414	Cms ortholog CMS_2481
1097677006415	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1097677006416	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1097677006417	ABC transporter; Region: ABC_tran_2; pfam12848
1097677006418	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1097677006419	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677006420	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
1097677006421	Predicted membrane protein [Function unknown]; Region: COG2246
1097677006422	GtrA-like protein; Region: GtrA; pfam04138
1097677006423	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
1097677006424	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
1097677006425	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1097677006426	Ligand binding site; other site
1097677006427	Putative Catalytic site; other site
1097677006428	DXD motif; other site
1097677006429	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1097677006430	MoaE homodimer interface [polypeptide binding]; other site
1097677006431	MoaD interaction [polypeptide binding]; other site
1097677006432	active site residues [active]
1097677006433	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
1097677006434	MPT binding site; other site
1097677006435	molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364
1097677006436	trimer interface [polypeptide binding]; other site
1097677006437	dimer interface [polypeptide binding]; other site
1097677006438	putative active site [active]
1097677006439	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1097677006440	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1097677006441	dimer interface [polypeptide binding]; other site
1097677006442	putative functional site; other site
1097677006443	putative MPT binding site; other site
1097677006444	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1097677006445	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1097677006446	tetramer interface [polypeptide binding]; other site
1097677006447	active site
1097677006448	Mg2+/Mn2+ binding site [ion binding]; other site
1097677006449	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1097677006450	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097677006451	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677006452	NAD(P) binding site [chemical binding]; other site
1097677006453	active site
1097677006454	Cmm ortholog CMM_2320; Cms ortholog CMS_2499
1097677006455	Cmm ortholog CMM_2321; Cms ortholog CMS_2500
1097677006456	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1097677006457	Predicted permease; Region: DUF318; cl17795
1097677006458	TIGR03943 family protein; Region: TIGR03943
1097677006459	Predicted transcriptional regulators [Transcription]; Region: COG1695
1097677006460	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1097677006461	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
1097677006462	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1097677006463	Moco binding site; other site
1097677006464	metal coordination site [ion binding]; other site
1097677006465	dimerization interface [polypeptide binding]; other site
1097677006466	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097677006467	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097677006468	dimer interface [polypeptide binding]; other site
1097677006469	phosphorylation site [posttranslational modification]
1097677006470	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097677006471	ATP binding site [chemical binding]; other site
1097677006472	Mg2+ binding site [ion binding]; other site
1097677006473	G-X-G motif; other site
1097677006474	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097677006475	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677006476	active site
1097677006477	phosphorylation site [posttranslational modification]
1097677006478	intermolecular recognition site; other site
1097677006479	dimerization interface [polypeptide binding]; other site
1097677006480	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097677006481	DNA binding site [nucleotide binding]
1097677006482	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1097677006483	Ligand binding site; other site
1097677006484	Putative Catalytic site; other site
1097677006485	DXD motif; other site
1097677006486	Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492
1097677006487	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1097677006488	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1097677006489	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321
1097677006490	Moco binding site; other site
1097677006491	metal coordination site [ion binding]; other site
1097677006492	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
1097677006493	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
1097677006494	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677006495	Walker A/P-loop; other site
1097677006496	ATP binding site [chemical binding]; other site
1097677006497	Q-loop/lid; other site
1097677006498	ABC transporter signature motif; other site
1097677006499	Walker B; other site
1097677006500	D-loop; other site
1097677006501	H-loop/switch region; other site
1097677006502	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1097677006503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677006504	putative PBP binding loops; other site
1097677006505	ABC-ATPase subunit interface; other site
1097677006506	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1097677006507	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1097677006508	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
1097677006509	DNA binding residues [nucleotide binding]
1097677006510	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
1097677006511	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1097677006512	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097677006513	FeS/SAM binding site; other site
1097677006514	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1097677006515	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1097677006516	MoaE interaction surface [polypeptide binding]; other site
1097677006517	MoeB interaction surface [polypeptide binding]; other site
1097677006518	thiocarboxylated glycine; other site
1097677006519	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097677006520	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1097677006521	active site
1097677006522	metal binding site [ion binding]; metal-binding site
1097677006523	Predicted transcriptional regulator [Transcription]; Region: COG2378
1097677006524	HTH domain; Region: HTH_11; pfam08279
1097677006525	WYL domain; Region: WYL; pfam13280
1097677006526	Predicted transcriptional regulators [Transcription]; Region: COG1725
1097677006527	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097677006528	DNA-binding site [nucleotide binding]; DNA binding site
1097677006529	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097677006530	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1097677006531	dimer interface [polypeptide binding]; other site
1097677006532	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097677006533	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097677006534	DNA binding site [nucleotide binding]
1097677006535	domain linker motif; other site
1097677006536	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1097677006537	ligand binding site [chemical binding]; other site
1097677006538	dimerization interface [polypeptide binding]; other site
1097677006539	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097677006540	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097677006541	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097677006542	active site
1097677006543	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097677006544	catalytic tetrad [active]
1097677006545	MarR family; Region: MarR_2; pfam12802
1097677006546	MarR family; Region: MarR_2; cl17246
1097677006547	short chain dehydrogenase; Provisional; Region: PRK05854
1097677006548	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677006549	NAD(P) binding site [chemical binding]; other site
1097677006550	active site
1097677006551	Helix-turn-helix domain; Region: HTH_31; pfam13560
1097677006552	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1097677006553	hypothetical protein; Validated; Region: PRK07411
1097677006554	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1097677006555	ATP binding site [chemical binding]; other site
1097677006556	substrate interface [chemical binding]; other site
1097677006557	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1097677006558	active site residue [active]
1097677006559	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1097677006560	Cmm ortholog; Cms ortholog CMS_2542
1097677006561	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
1097677006562	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1097677006563	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1097677006564	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1097677006565	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1097677006566	active site
1097677006567	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
1097677006568	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1097677006569	active site
1097677006570	HIGH motif; other site
1097677006571	KMSKS motif; other site
1097677006572	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1097677006573	tRNA binding surface [nucleotide binding]; other site
1097677006574	anticodon binding site; other site
1097677006575	citrate synthase; Provisional; Region: PRK14033
1097677006576	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
1097677006577	oxalacetate binding site [chemical binding]; other site
1097677006578	citrylCoA binding site [chemical binding]; other site
1097677006579	coenzyme A binding site [chemical binding]; other site
1097677006580	catalytic triad [active]
1097677006581	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
1097677006582	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097677006583	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097677006584	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1097677006585	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1097677006586	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1097677006589	Domain of unknown function DUF87; Region: DUF87; pfam01935
1097677006590	Domain of unknown function DUF87; Region: DUF87; pfam01935
1097677006591	HerA helicase [Replication, recombination, and repair]; Region: COG0433
1097677006592	SIR2-like domain; Region: SIR2_2; pfam13289
1097677006593	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1097677006594	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1097677006595	tetramer interface [polypeptide binding]; other site
1097677006596	active site
1097677006597	Mg2+/Mn2+ binding site [ion binding]; other site
1097677006598	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
1097677006599	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097677006600	Coenzyme A binding pocket [chemical binding]; other site
1097677006601	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1097677006602	Predicted membrane protein [Function unknown]; Region: COG2259
1097677006603	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1097677006604	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
1097677006605	active site
1097677006606	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1097677006607	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
1097677006608	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
1097677006609	active site
1097677006610	catalytic site [active]
1097677006611	EamA-like transporter family; Region: EamA; pfam00892
1097677006612	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
1097677006613	CGNR zinc finger; Region: zf-CGNR; pfam11706
1097677006614	Predicted methyltransferases [General function prediction only]; Region: COG0313
1097677006615	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1097677006616	putative SAM binding site [chemical binding]; other site
1097677006617	putative homodimer interface [polypeptide binding]; other site
1097677006618	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
1097677006619	Proline dehydrogenase; Region: Pro_dh; cl03282
1097677006620	trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455
1097677006621	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1097677006622	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
1097677006623	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
1097677006624	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1097677006625	homodimer interface [polypeptide binding]; other site
1097677006626	substrate-cofactor binding pocket; other site
1097677006627	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677006628	catalytic residue [active]
1097677006629	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1097677006630	Domain of unknown function (DUF427); Region: DUF427; pfam04248
1097677006631	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1097677006632	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1097677006633	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1097677006634	SdpI/YhfL protein family; Region: SdpI; pfam13630
1097677006635	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
1097677006636	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
1097677006637	catalytic residues [active]
1097677006638	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1097677006639	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
1097677006640	oligomer interface [polypeptide binding]; other site
1097677006641	metal binding site [ion binding]; metal-binding site
1097677006642	metal binding site [ion binding]; metal-binding site
1097677006643	putative Cl binding site [ion binding]; other site
1097677006644	basic sphincter; other site
1097677006645	hydrophobic gate; other site
1097677006646	periplasmic entrance; other site
1097677006647	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097677006648	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097677006649	active site
1097677006650	catalytic tetrad [active]
1097677006651	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1097677006652	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
1097677006653	acyl-activating enzyme (AAE) consensus motif; other site
1097677006654	putative AMP binding site [chemical binding]; other site
1097677006655	putative active site [active]
1097677006656	putative CoA binding site [chemical binding]; other site
1097677006657	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
1097677006658	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097677006659	ATP binding site [chemical binding]; other site
1097677006660	putative Mg++ binding site [ion binding]; other site
1097677006661	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097677006662	nucleotide binding region [chemical binding]; other site
1097677006663	ATP-binding site [chemical binding]; other site
1097677006664	Helicase associated domain (HA2); Region: HA2; pfam04408
1097677006665	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
1097677006666	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
1097677006667	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1097677006668	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097677006669	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097677006670	DNA-binding site [nucleotide binding]; DNA binding site
1097677006671	FCD domain; Region: FCD; pfam07729
1097677006672	urea carboxylase; Region: urea_carbox; TIGR02712
1097677006673	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1097677006674	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1097677006675	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1097677006676	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
1097677006677	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1097677006678	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1097677006679	carboxyltransferase (CT) interaction site; other site
1097677006680	biotinylation site [posttranslational modification]; other site
1097677006681	allophanate hydrolase; Region: allophanate_hyd; TIGR02713
1097677006682	Amidase; Region: Amidase; cl11426
1097677006683	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1097677006684	AAA domain; Region: AAA_18; pfam13238
1097677006685	active site
1097677006686	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1097677006687	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1097677006688	active site residue [active]
1097677006689	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1097677006690	active site residue [active]
1097677006691	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097677006692	Coenzyme A binding pocket [chemical binding]; other site
1097677006693	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1097677006694	dimer interface [polypeptide binding]; other site
1097677006695	putative radical transfer pathway; other site
1097677006696	diiron center [ion binding]; other site
1097677006697	tyrosyl radical; other site
1097677006698	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK06539
1097677006699	ATP cone domain; Region: ATP-cone; pfam03477
1097677006700	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1097677006701	active site
1097677006702	dimer interface [polypeptide binding]; other site
1097677006703	catalytic residues [active]
1097677006704	effector binding site; other site
1097677006705	R2 peptide binding site; other site
1097677006706	H+ Antiporter protein; Region: 2A0121; TIGR00900
1097677006707	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097677006708	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097677006709	active site
1097677006710	catalytic tetrad [active]
1097677006711	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1097677006712	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1097677006713	protein binding site [polypeptide binding]; other site
1097677006714	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
1097677006715	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
1097677006716	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097677006717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677006718	dimer interface [polypeptide binding]; other site
1097677006719	conserved gate region; other site
1097677006720	putative PBP binding loops; other site
1097677006721	ABC-ATPase subunit interface; other site
1097677006722	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1097677006723	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677006724	dimer interface [polypeptide binding]; other site
1097677006725	ABC-ATPase subunit interface; other site
1097677006726	putative PBP binding loops; other site
1097677006727	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1097677006728	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097677006729	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097677006730	DNA binding site [nucleotide binding]
1097677006731	domain linker motif; other site
1097677006732	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1097677006733	dimerization interface [polypeptide binding]; other site
1097677006734	ligand binding site [chemical binding]; other site
1097677006735	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
1097677006736	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
1097677006737	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097677006738	S-adenosylmethionine binding site [chemical binding]; other site
1097677006739	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1097677006740	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
1097677006741	CBD_II domain; Region: CBD_II; smart00637
1097677006742	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1097677006743	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1097677006744	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1097677006745	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1097677006746	active site
1097677006747	tetramer interface; other site
1097677006748	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1097677006749	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1097677006750	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
1097677006751	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
1097677006752	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1097677006753	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
1097677006754	Part of AAA domain; Region: AAA_19; pfam13245
1097677006755	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1097677006756	Helix-turn-helix; Region: HTH_3; pfam01381
1097677006757	sequence-specific DNA binding site [nucleotide binding]; other site
1097677006758	salt bridge; other site
1097677006759	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1097677006760	active site
1097677006761	NTP binding site [chemical binding]; other site
1097677006762	metal binding triad [ion binding]; metal-binding site
1097677006763	antibiotic binding site [chemical binding]; other site
1097677006764	Protein of unknown function DUF86; Region: DUF86; cl01031
1097677006765	Uncharacterized conserved protein [Function unknown]; Region: COG4748
1097677006766	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
1097677006767	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
1097677006768	homodimer interface [polypeptide binding]; other site
1097677006769	chemical substrate binding site [chemical binding]; other site
1097677006770	oligomer interface [polypeptide binding]; other site
1097677006771	metal binding site [ion binding]; metal-binding site
1097677006772	GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439
1097677006773	GIY-YIG motif/motif A; other site
1097677006774	putative active site [active]
1097677006775	putative metal binding site [ion binding]; other site
1097677006776	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1097677006777	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
1097677006778	Uncharacterized conserved protein [Function unknown]; Region: COG3410
1097677006779	flap endonuclease-1; Provisional; Region: PRK03980
1097677006780	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1097677006781	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1097677006782	Na binding site [ion binding]; other site
1097677006783	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1097677006784	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1097677006785	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1097677006786	Protein of unknown function (DUF917); Region: DUF917; pfam06032
1097677006787	Protein of unknown function (DUF917); Region: DUF917; pfam06032
1097677006788	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1097677006789	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
1097677006790	Domain of unknown function (DUF4041); Region: DUF4041; pfam13250
1097677006791	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
1097677006792	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1097677006793	Lsr2; Region: Lsr2; pfam11774
1097677006794	Cmm ortholog CMM_2463; Cms ortholog CMS_2771 (pseudogene)
1097677006795	Bacterial transcriptional activator domain; Region: BTAD; smart01043
1097677006796	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
1097677006797	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097677006798	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1097677006799	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1097677006800	active site
1097677006801	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1097677006802	NlpC/P60 family; Region: NLPC_P60; pfam00877
1097677006803	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1097677006804	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
1097677006805	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1097677006806	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
1097677006807	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1097677006808	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097677006809	catalytic residue [active]
1097677006810	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
1097677006811	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1097677006812	DNA-binding site [nucleotide binding]; DNA binding site
1097677006813	RNA-binding motif; other site
1097677006814	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1097677006815	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1097677006816	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1097677006817	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097677006818	ATP binding site [chemical binding]; other site
1097677006819	putative Mg++ binding site [ion binding]; other site
1097677006820	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097677006821	nucleotide binding region [chemical binding]; other site
1097677006822	ATP-binding site [chemical binding]; other site
1097677006823	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097677006824	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677006825	active site
1097677006826	phosphorylation site [posttranslational modification]
1097677006827	intermolecular recognition site; other site
1097677006828	dimerization interface [polypeptide binding]; other site
1097677006829	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097677006830	DNA binding site [nucleotide binding]
1097677006831	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1097677006832	dimerization interface [polypeptide binding]; other site
1097677006833	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097677006834	dimer interface [polypeptide binding]; other site
1097677006835	phosphorylation site [posttranslational modification]
1097677006836	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097677006837	ATP binding site [chemical binding]; other site
1097677006838	Mg2+ binding site [ion binding]; other site
1097677006839	G-X-G motif; other site
1097677006840	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1097677006841	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1097677006842	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1097677006843	ring oligomerisation interface [polypeptide binding]; other site
1097677006844	ATP/Mg binding site [chemical binding]; other site
1097677006845	stacking interactions; other site
1097677006846	hinge regions; other site
1097677006847	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1097677006848	DNA-binding site [nucleotide binding]; DNA binding site
1097677006849	RNA-binding motif; other site
1097677006850	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1097677006851	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1097677006852	SelR domain; Region: SelR; pfam01641
1097677006853	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1097677006854	putative FMN binding site [chemical binding]; other site
1097677006855	Thioredoxin; Region: Thioredoxin_4; cl17273
1097677006856	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1097677006857	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1097677006858	Walker A/P-loop; other site
1097677006859	ATP binding site [chemical binding]; other site
1097677006860	Q-loop/lid; other site
1097677006861	ABC transporter signature motif; other site
1097677006862	Walker B; other site
1097677006863	D-loop; other site
1097677006864	H-loop/switch region; other site
1097677006865	TOBE domain; Region: TOBE_2; pfam08402
1097677006866	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
1097677006867	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1097677006868	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1097677006869	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1097677006870	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1097677006871	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1097677006872	active site
1097677006873	HIGH motif; other site
1097677006874	nucleotide binding site [chemical binding]; other site
1097677006875	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1097677006876	KMSKS motif; other site
1097677006877	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1097677006878	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
1097677006879	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1097677006880	substrate binding site; other site
1097677006881	dimer interface; other site
1097677006882	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1097677006883	homotrimer interaction site [polypeptide binding]; other site
1097677006884	zinc binding site [ion binding]; other site
1097677006885	CDP-binding sites; other site
1097677006886	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
1097677006887	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097677006888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677006889	active site
1097677006890	phosphorylation site [posttranslational modification]
1097677006891	intermolecular recognition site; other site
1097677006892	dimerization interface [polypeptide binding]; other site
1097677006893	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097677006894	DNA binding site [nucleotide binding]
1097677006895	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1097677006896	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097677006897	dimer interface [polypeptide binding]; other site
1097677006898	phosphorylation site [posttranslational modification]
1097677006899	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097677006900	ATP binding site [chemical binding]; other site
1097677006901	Mg2+ binding site [ion binding]; other site
1097677006902	G-X-G motif; other site
1097677006903	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1097677006904	PhoU domain; Region: PhoU; pfam01895
1097677006905	PhoU domain; Region: PhoU; pfam01895
1097677006906	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1097677006907	catalytic core [active]
1097677006908	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1097677006909	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097677006910	S-adenosylmethionine binding site [chemical binding]; other site
1097677006911	Predicted membrane protein [Function unknown]; Region: COG4129
1097677006912	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1097677006913	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1097677006914	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1097677006915	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
1097677006916	heme-binding site [chemical binding]; other site
1097677006917	DNA-binding response regulator CreB; Provisional; Region: PRK11083
1097677006918	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097677006919	DNA binding site [nucleotide binding]
1097677006920	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
1097677006921	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097677006922	Coenzyme A binding pocket [chemical binding]; other site
1097677006923	polyphosphate kinase; Provisional; Region: PRK05443
1097677006924	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1097677006925	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1097677006926	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1097677006927	putative domain interface [polypeptide binding]; other site
1097677006928	putative active site [active]
1097677006929	catalytic site [active]
1097677006930	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1097677006931	putative domain interface [polypeptide binding]; other site
1097677006932	putative active site [active]
1097677006933	catalytic site [active]
1097677006934	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1097677006935	active site
1097677006936	Ap6A binding site [chemical binding]; other site
1097677006937	nudix motif; other site
1097677006938	metal binding site [ion binding]; metal-binding site
1097677006939	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1097677006940	catalytic core [active]
1097677006941	PBP superfamily domain; Region: PBP_like_2; cl17296
1097677006942	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
1097677006943	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677006944	dimer interface [polypeptide binding]; other site
1097677006945	conserved gate region; other site
1097677006946	putative PBP binding loops; other site
1097677006947	ABC-ATPase subunit interface; other site
1097677006948	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1097677006949	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677006950	dimer interface [polypeptide binding]; other site
1097677006951	conserved gate region; other site
1097677006952	putative PBP binding loops; other site
1097677006953	ABC-ATPase subunit interface; other site
1097677006954	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
1097677006955	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1097677006956	Walker A/P-loop; other site
1097677006957	ATP binding site [chemical binding]; other site
1097677006958	Q-loop/lid; other site
1097677006959	ABC transporter signature motif; other site
1097677006960	Walker B; other site
1097677006961	D-loop; other site
1097677006962	H-loop/switch region; other site
1097677006963	Anti-sigma-K factor rskA; Region: RskA; pfam10099
1097677006964	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
1097677006965	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097677006966	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097677006967	DNA binding residues [nucleotide binding]
1097677006968	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
1097677006969	catalytic triad [active]
1097677006970	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
1097677006971	active site
1097677006972	catalytic residues [active]
1097677006973	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
1097677006974	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1097677006975	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1097677006976	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1097677006977	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
1097677006978	nucleotide binding site/active site [active]
1097677006979	HIT family signature motif; other site
1097677006980	catalytic residue [active]
1097677006981	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
1097677006982	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1097677006983	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1097677006984	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1097677006985	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1097677006986	trimer interface [polypeptide binding]; other site
1097677006987	putative metal binding site [ion binding]; other site
1097677006988	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
1097677006989	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1097677006990	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1097677006991	homodimer interface [polypeptide binding]; other site
1097677006992	NADP binding site [chemical binding]; other site
1097677006993	substrate binding site [chemical binding]; other site
1097677006994	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1097677006995	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1097677006996	dimer interface [polypeptide binding]; other site
1097677006997	active site
1097677006998	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1097677006999	folate binding site [chemical binding]; other site
1097677007000	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1097677007001	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1097677007002	H+ Antiporter protein; Region: 2A0121; TIGR00900
1097677007003	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677007004	putative substrate translocation pore; other site
1097677007005	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097677007006	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097677007007	active site
1097677007008	catalytic tetrad [active]
1097677007009	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1097677007010	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097677007011	putative DNA binding site [nucleotide binding]; other site
1097677007012	putative Zn2+ binding site [ion binding]; other site
1097677007013	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1097677007014	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
1097677007015	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1097677007016	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
1097677007017	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1097677007018	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097677007019	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1097677007020	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1097677007021	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1097677007022	putative active site [active]
1097677007023	putative substrate binding site [chemical binding]; other site
1097677007024	putative cosubstrate binding site; other site
1097677007025	catalytic site [active]
1097677007026	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1097677007027	Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852
1097677007028	active site
1097677007029	catalytic triad [active]
1097677007030	PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120
1097677007031	PA/protease or protease-like domain interface [polypeptide binding]; other site
1097677007032	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1097677007033	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1097677007034	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1097677007035	active site
1097677007036	catalytic residues [active]
1097677007037	PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120
1097677007038	PA/protease or protease-like domain interface [polypeptide binding]; other site
1097677007039	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1097677007040	catalytic residues [active]
1097677007041	isocitrate dehydrogenase; Validated; Region: PRK08299
1097677007042	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097677007043	Coenzyme A binding pocket [chemical binding]; other site
1097677007044	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1097677007045	DNA binding site [nucleotide binding]
1097677007046	active site
1097677007047	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1097677007048	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
1097677007049	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677007050	Walker A/P-loop; other site
1097677007051	ATP binding site [chemical binding]; other site
1097677007052	Q-loop/lid; other site
1097677007053	ABC transporter signature motif; other site
1097677007054	Walker B; other site
1097677007055	D-loop; other site
1097677007056	H-loop/switch region; other site
1097677007057	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
1097677007058	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1097677007059	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677007060	Walker A/P-loop; other site
1097677007061	ATP binding site [chemical binding]; other site
1097677007062	Q-loop/lid; other site
1097677007063	ABC transporter signature motif; other site
1097677007064	Walker B; other site
1097677007065	D-loop; other site
1097677007066	H-loop/switch region; other site
1097677007067	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
1097677007068	Amidinotransferase; Region: Amidinotransf; cl12043
1097677007069	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1097677007070	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1097677007071	purine monophosphate binding site [chemical binding]; other site
1097677007072	dimer interface [polypeptide binding]; other site
1097677007073	putative catalytic residues [active]
1097677007074	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1097677007075	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1097677007076	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1097677007077	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1097677007078	active site
1097677007079	substrate binding site [chemical binding]; other site
1097677007080	cosubstrate binding site; other site
1097677007081	catalytic site [active]
1097677007082	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1097677007083	CoA binding domain; Region: CoA_binding; smart00881
1097677007084	CoA-ligase; Region: Ligase_CoA; pfam00549
1097677007085	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1097677007086	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1097677007087	CoA-ligase; Region: Ligase_CoA; pfam00549
1097677007088	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
1097677007089	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1097677007090	Part of AAA domain; Region: AAA_19; pfam13245
1097677007091	Family description; Region: UvrD_C_2; pfam13538
1097677007092	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1097677007093	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1097677007094	active site
1097677007095	catalytic site [active]
1097677007096	Bax inhibitor 1 like; Region: BaxI_1; cl17691
1097677007097	GMP synthase; Reviewed; Region: guaA; PRK00074
1097677007098	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1097677007099	AMP/PPi binding site [chemical binding]; other site
1097677007100	candidate oxyanion hole; other site
1097677007101	catalytic triad [active]
1097677007102	potential glutamine specificity residues [chemical binding]; other site
1097677007103	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1097677007104	ATP Binding subdomain [chemical binding]; other site
1097677007105	Ligand Binding sites [chemical binding]; other site
1097677007106	Dimerization subdomain; other site
1097677007107	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1097677007108	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cl01321
1097677007109	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1097677007110	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1097677007111	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
1097677007112	TrkA-C domain; Region: TrkA_C; pfam02080
1097677007113	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
1097677007114	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1097677007115	active site
1097677007116	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1097677007117	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1097677007118	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1097677007119	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1097677007120	active site
1097677007121	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097677007122	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097677007123	TM-ABC transporter signature motif; other site
1097677007124	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097677007125	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097677007126	TM-ABC transporter signature motif; other site
1097677007127	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097677007128	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097677007129	Walker A/P-loop; other site
1097677007130	ATP binding site [chemical binding]; other site
1097677007131	Q-loop/lid; other site
1097677007132	ABC transporter signature motif; other site
1097677007133	Walker B; other site
1097677007134	D-loop; other site
1097677007135	H-loop/switch region; other site
1097677007136	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097677007137	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097677007138	Walker A/P-loop; other site
1097677007139	ATP binding site [chemical binding]; other site
1097677007140	Q-loop/lid; other site
1097677007141	ABC transporter signature motif; other site
1097677007142	Walker B; other site
1097677007143	D-loop; other site
1097677007144	H-loop/switch region; other site
1097677007145	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097677007146	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1097677007147	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1097677007148	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1097677007149	oligomerisation interface [polypeptide binding]; other site
1097677007150	mobile loop; other site
1097677007151	roof hairpin; other site
1097677007152	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
1097677007153	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1097677007154	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097677007155	Coenzyme A binding pocket [chemical binding]; other site
1097677007156	UGMP family protein; Validated; Region: PRK09604
1097677007157	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1097677007158	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1097677007159	Glycoprotease family; Region: Peptidase_M22; pfam00814
1097677007160	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1097677007161	alanine racemase; Reviewed; Region: alr; PRK00053
1097677007162	active site
1097677007163	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1097677007164	dimer interface [polypeptide binding]; other site
1097677007165	substrate binding site [chemical binding]; other site
1097677007166	catalytic residues [active]
1097677007167	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367
1097677007168	alanine racemase; Reviewed; Region: alr; PRK00053
1097677007169	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1097677007170	active site
1097677007171	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1097677007172	dimer interface [polypeptide binding]; other site
1097677007173	substrate binding site [chemical binding]; other site
1097677007174	catalytic residues [active]
1097677007175	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1097677007176	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1097677007177	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1097677007178	glutaminase active site [active]
1097677007179	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1097677007180	dimer interface [polypeptide binding]; other site
1097677007181	active site
1097677007182	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1097677007183	dimer interface [polypeptide binding]; other site
1097677007184	active site
1097677007185	pantothenate kinase; Provisional; Region: PRK05439
1097677007186	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1097677007187	ATP-binding site [chemical binding]; other site
1097677007188	CoA-binding site [chemical binding]; other site
1097677007189	Mg2+-binding site [ion binding]; other site
1097677007190	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
1097677007191	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1097677007192	active site
1097677007193	substrate binding site [chemical binding]; other site
1097677007194	metal binding site [ion binding]; metal-binding site
1097677007195	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1097677007196	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1097677007197	23S rRNA interface [nucleotide binding]; other site
1097677007198	L3 interface [polypeptide binding]; other site
1097677007199	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1097677007200	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1097677007201	dimerization interface 3.5A [polypeptide binding]; other site
1097677007202	active site
1097677007203	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1097677007204	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097677007205	Coenzyme A binding pocket [chemical binding]; other site
1097677007206	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1097677007207	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1097677007208	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1097677007209	alphaNTD homodimer interface [polypeptide binding]; other site
1097677007210	alphaNTD - beta interaction site [polypeptide binding]; other site
1097677007211	alphaNTD - beta' interaction site [polypeptide binding]; other site
1097677007212	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1097677007213	30S ribosomal protein S11; Validated; Region: PRK05309
1097677007214	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1097677007215	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1097677007216	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1097677007217	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1097677007218	rRNA binding site [nucleotide binding]; other site
1097677007219	predicted 30S ribosome binding site; other site
1097677007220	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1097677007221	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1097677007222	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1097677007223	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1097677007224	active site
1097677007225	phosphorylation site [posttranslational modification]
1097677007226	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
1097677007227	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1097677007228	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1097677007229	active site
1097677007230	P-loop; other site
1097677007231	phosphorylation site [posttranslational modification]
1097677007232	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1097677007233	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1097677007234	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
1097677007235	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1097677007236	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1097677007237	dimerization domain swap beta strand [polypeptide binding]; other site
1097677007238	regulatory protein interface [polypeptide binding]; other site
1097677007239	active site
1097677007240	regulatory phosphorylation site [posttranslational modification]; other site
1097677007241	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
1097677007242	active site
1097677007243	P-loop; other site
1097677007244	phosphorylation site [posttranslational modification]
1097677007245	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1097677007246	HTH domain; Region: HTH_11; pfam08279
1097677007247	PRD domain; Region: PRD; pfam00874
1097677007248	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
1097677007249	active site
1097677007250	P-loop; other site
1097677007251	phosphorylation site [posttranslational modification]
1097677007252	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1097677007253	active site
1097677007254	phosphorylation site [posttranslational modification]
1097677007255	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1097677007256	active site
1097677007257	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1097677007258	Adenylate kinase; Region: ADK; pfam00406
1097677007259	AMP-binding site [chemical binding]; other site
1097677007260	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1097677007261	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1097677007262	SecY translocase; Region: SecY; pfam00344
1097677007263	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1097677007264	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1097677007265	23S rRNA binding site [nucleotide binding]; other site
1097677007266	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1097677007267	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1097677007268	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1097677007269	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1097677007270	5S rRNA interface [nucleotide binding]; other site
1097677007271	L27 interface [polypeptide binding]; other site
1097677007272	23S rRNA interface [nucleotide binding]; other site
1097677007273	L5 interface [polypeptide binding]; other site
1097677007274	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1097677007275	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1097677007276	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1097677007277	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1097677007278	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1097677007279	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1097677007280	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1097677007281	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1097677007282	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1097677007283	RNA binding site [nucleotide binding]; other site
1097677007284	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1097677007285	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1097677007286	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1097677007287	L23 interface [polypeptide binding]; other site
1097677007288	signal recognition particle (SRP54) interaction site; other site
1097677007289	trigger factor interaction site; other site
1097677007290	23S rRNA interface [nucleotide binding]; other site
1097677007291	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1097677007292	23S rRNA interface [nucleotide binding]; other site
1097677007293	5S rRNA interface [nucleotide binding]; other site
1097677007294	putative antibiotic binding site [chemical binding]; other site
1097677007295	L25 interface [polypeptide binding]; other site
1097677007296	L27 interface [polypeptide binding]; other site
1097677007297	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1097677007298	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1097677007299	G-X-X-G motif; other site
1097677007300	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1097677007301	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1097677007302	protein-rRNA interface [nucleotide binding]; other site
1097677007303	putative translocon binding site; other site
1097677007304	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1097677007305	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1097677007306	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1097677007307	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1097677007308	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1097677007309	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1097677007310	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1097677007311	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1097677007312	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
1097677007313	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
1097677007314	active site
1097677007315	DNA binding site [nucleotide binding]
1097677007316	Int/Topo IB signature motif; other site
1097677007317	elongation factor Tu; Reviewed; Region: PRK00049
1097677007318	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1097677007319	G1 box; other site
1097677007320	GEF interaction site [polypeptide binding]; other site
1097677007321	GTP/Mg2+ binding site [chemical binding]; other site
1097677007322	Switch I region; other site
1097677007323	G2 box; other site
1097677007324	G3 box; other site
1097677007325	Switch II region; other site
1097677007326	G4 box; other site
1097677007327	G5 box; other site
1097677007328	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1097677007329	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1097677007330	Antibiotic Binding Site [chemical binding]; other site
1097677007331	elongation factor G; Reviewed; Region: PRK00007
1097677007332	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1097677007333	G1 box; other site
1097677007334	putative GEF interaction site [polypeptide binding]; other site
1097677007335	GTP/Mg2+ binding site [chemical binding]; other site
1097677007336	Switch I region; other site
1097677007337	G2 box; other site
1097677007338	G3 box; other site
1097677007339	Switch II region; other site
1097677007340	G4 box; other site
1097677007341	G5 box; other site
1097677007342	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1097677007343	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1097677007344	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1097677007345	30S ribosomal protein S7; Validated; Region: PRK05302
1097677007346	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1097677007347	S17 interaction site [polypeptide binding]; other site
1097677007348	S8 interaction site; other site
1097677007349	16S rRNA interaction site [nucleotide binding]; other site
1097677007350	streptomycin interaction site [chemical binding]; other site
1097677007351	23S rRNA interaction site [nucleotide binding]; other site
1097677007352	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1097677007353	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1097677007354	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677007355	Walker A/P-loop; other site
1097677007356	ATP binding site [chemical binding]; other site
1097677007357	Q-loop/lid; other site
1097677007358	ABC transporter signature motif; other site
1097677007359	Walker B; other site
1097677007360	D-loop; other site
1097677007361	H-loop/switch region; other site
1097677007362	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677007363	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097677007364	dimer interface [polypeptide binding]; other site
1097677007365	conserved gate region; other site
1097677007366	putative PBP binding loops; other site
1097677007367	ABC-ATPase subunit interface; other site
1097677007368	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1097677007369	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097677007370	substrate binding pocket [chemical binding]; other site
1097677007371	membrane-bound complex binding site; other site
1097677007372	hinge residues; other site
1097677007373	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1097677007374	DNA-directed RNA polymerase, gamma subunit; Region: rpoC1_cyan; TIGR02387
1097677007375	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1097677007376	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1097677007377	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1097677007378	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1097677007379	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1097677007380	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1097677007381	G-loop; other site
1097677007382	DNA binding site [nucleotide binding]
1097677007383	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1097677007384	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1097677007385	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1097677007386	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1097677007387	RPB10 interaction site [polypeptide binding]; other site
1097677007388	RPB1 interaction site [polypeptide binding]; other site
1097677007389	RPB11 interaction site [polypeptide binding]; other site
1097677007390	RPB3 interaction site [polypeptide binding]; other site
1097677007391	RPB12 interaction site [polypeptide binding]; other site
1097677007392	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1097677007393	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1097677007394	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
1097677007395	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1097677007396	SprT-like family; Region: SprT-like; pfam10263
1097677007397	SprT homologues; Region: SprT; cl01182
1097677007398	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
1097677007399	CGNR zinc finger; Region: zf-CGNR; pfam11706
1097677007400	Domain of unknown function (DUF427); Region: DUF427; pfam04248
1097677007401	EVE domain; Region: EVE; cl00728
1097677007402	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
1097677007403	helicase 45; Provisional; Region: PTZ00424
1097677007404	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1097677007405	ATP binding site [chemical binding]; other site
1097677007406	putative Mg++ binding site [ion binding]; other site
1097677007407	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097677007408	nucleotide binding region [chemical binding]; other site
1097677007409	ATP-binding site [chemical binding]; other site
1097677007410	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677007411	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1097677007412	nudix motif; other site
1097677007413	Predicted esterase [General function prediction only]; Region: COG0400
1097677007414	putative hydrolase; Provisional; Region: PRK11460
1097677007415	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097677007416	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
1097677007417	ATP binding site [chemical binding]; other site
1097677007418	putative Mg++ binding site [ion binding]; other site
1097677007419	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097677007420	nucleotide binding region [chemical binding]; other site
1097677007421	ATP-binding site [chemical binding]; other site
1097677007422	DEAD/H associated; Region: DEAD_assoc; pfam08494
1097677007423	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1097677007424	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
1097677007425	putative DNA binding site [nucleotide binding]; other site
1097677007426	catalytic residue [active]
1097677007427	putative H2TH interface [polypeptide binding]; other site
1097677007428	putative catalytic residues [active]
1097677007429	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1097677007430	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1097677007431	amino acid transporter; Region: 2A0306; TIGR00909
1097677007432	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1097677007433	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
1097677007434	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097677007435	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1097677007436	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097677007437	DNA binding residues [nucleotide binding]
1097677007438	ANTAR domain; Region: ANTAR; pfam03861
1097677007439	PspC domain; Region: PspC; pfam04024
1097677007440	amidase; Provisional; Region: PRK08137
1097677007441	Amidase; Region: Amidase; cl11426
1097677007442	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
1097677007443	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1097677007444	active site
1097677007445	Beta-lactamase; Region: Beta-lactamase; pfam00144
1097677007446	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1097677007447	Cmm ortholog CMM_2661; Cms ortholog CMS_0397
1097677007448	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
1097677007449	putative FMN binding site [chemical binding]; other site
1097677007450	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097677007451	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097677007452	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1097677007453	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1097677007454	conserved cys residue [active]
1097677007455	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1097677007456	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1097677007457	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1097677007458	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677007459	Walker A/P-loop; other site
1097677007460	ATP binding site [chemical binding]; other site
1097677007461	Q-loop/lid; other site
1097677007462	ABC transporter signature motif; other site
1097677007463	Walker B; other site
1097677007464	D-loop; other site
1097677007465	H-loop/switch region; other site
1097677007466	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1097677007467	dinuclear metal binding motif [ion binding]; other site
1097677007468	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097677007469	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677007470	active site
1097677007471	phosphorylation site [posttranslational modification]
1097677007472	intermolecular recognition site; other site
1097677007473	dimerization interface [polypeptide binding]; other site
1097677007474	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097677007475	DNA binding residues [nucleotide binding]
1097677007476	dimerization interface [polypeptide binding]; other site
1097677007477	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1097677007478	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1097677007479	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
1097677007480	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1097677007481	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097677007482	S-adenosylmethionine binding site [chemical binding]; other site
1097677007483	Cmm ortholog CMM_2669; Cms ortholog CMS_2639
1097677007484	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
1097677007485	Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693
1097677007486	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
1097677007487	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
1097677007488	putative dimer interface [polypeptide binding]; other site
1097677007489	catalytic triad [active]
1097677007490	Protein of unknown function (DUF1266); Region: DUF1266; cl14673
1097677007491	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1097677007492	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1097677007493	putative active site [active]
1097677007494	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1097677007495	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1097677007496	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097677007497	Cmm ortholog CMM_2678; no Cms ortholog
1097677007498	eukaryotic translation initiation factor 2 gamma subunit; Provisional; Region: PTZ00327
1097677007499	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097677007500	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1097677007501	Abi-like protein; Region: Abi_2; pfam07751
1097677007502	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
1097677007503	putative catalytic site [active]
1097677007504	putative metal binding site [ion binding]; other site
1097677007505	putative phosphate binding site [ion binding]; other site
1097677007506	Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241
1097677007507	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097677007508	active site
1097677007509	motif I; other site
1097677007510	motif II; other site
1097677007511	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1097677007512	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1097677007513	putative active site [active]
1097677007514	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1097677007515	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097677007516	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
1097677007517	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
1097677007518	putative ADP-binding pocket [chemical binding]; other site
1097677007519	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1097677007520	dimer interface [polypeptide binding]; other site
1097677007521	active site
1097677007522	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1097677007523	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1097677007524	active site
1097677007525	HIGH motif; other site
1097677007526	nucleotide binding site [chemical binding]; other site
1097677007527	classical (c) SDRs; Region: SDR_c; cd05233
1097677007528	NAD(P) binding site [chemical binding]; other site
1097677007529	active site
1097677007530	Cmm ortholog CMM_2689; no Cms ortholog
1097677007531	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
1097677007532	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
1097677007533	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
1097677007534	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1097677007535	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1097677007536	Pectate lyase; Region: Pec_lyase_C; cl01593
1097677007537	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097677007538	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097677007539	DNA binding site [nucleotide binding]
1097677007540	domain linker motif; other site
1097677007541	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
1097677007542	ligand binding site [chemical binding]; other site
1097677007543	dimerization interface (open form) [polypeptide binding]; other site
1097677007544	dimerization interface (closed form) [polypeptide binding]; other site
1097677007545	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1097677007546	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677007547	dimer interface [polypeptide binding]; other site
1097677007548	ABC-ATPase subunit interface; other site
1097677007549	putative PBP binding loops; other site
1097677007550	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097677007551	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677007552	dimer interface [polypeptide binding]; other site
1097677007553	conserved gate region; other site
1097677007554	putative PBP binding loops; other site
1097677007555	ABC-ATPase subunit interface; other site
1097677007556	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1097677007557	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1097677007558	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
1097677007559	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097677007560	NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078
1097677007561	NAD(P) binding site [chemical binding]; other site
1097677007562	catalytic residues [active]
1097677007563	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
1097677007564	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1097677007565	substrate binding site [chemical binding]; other site
1097677007566	ATP binding site [chemical binding]; other site
1097677007567	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
1097677007568	active site
1097677007569	nucleotide binding site [chemical binding]; other site
1097677007570	HIGH motif; other site
1097677007571	KMSKS motif; other site
1097677007572	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
1097677007573	Cmm ortholog CMM_2705; Cms ortholog CMS_2684
1097677007574	Zeta toxin; Region: Zeta_toxin; pfam06414
1097677007575	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
1097677007576	Helix-turn-helix domain; Region: HTH_17; pfam12728
1097677007577	AAA-like domain; Region: AAA_10; pfam12846
1097677007578	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1097677007579	Walker A motif; other site
1097677007580	ATP binding site [chemical binding]; other site
1097677007581	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
1097677007582	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
1097677007583	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1097677007584	GAF domain; Region: GAF; pfam01590
1097677007585	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1097677007586	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1097677007587	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1097677007588	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1097677007589	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1097677007590	anti sigma factor interaction site; other site
1097677007591	regulatory phosphorylation site [posttranslational modification]; other site
1097677007592	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1097677007593	catalytic core [active]
1097677007594	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
1097677007595	FMN binding site [chemical binding]; other site
1097677007596	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1097677007597	dimer interface [polypeptide binding]; other site
1097677007598	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1097677007599	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097677007600	Coenzyme A binding pocket [chemical binding]; other site
1097677007601	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
1097677007602	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1097677007603	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677007604	putative PBP binding loops; other site
1097677007605	dimer interface [polypeptide binding]; other site
1097677007606	ABC-ATPase subunit interface; other site
1097677007607	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097677007608	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097677007609	dimer interface [polypeptide binding]; other site
1097677007610	conserved gate region; other site
1097677007611	putative PBP binding loops; other site
1097677007612	ABC-ATPase subunit interface; other site
1097677007613	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1097677007614	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1097677007615	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1097677007616	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1097677007617	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1097677007618	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1097677007619	putative active site [active]
1097677007620	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1097677007621	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1097677007622	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1097677007623	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1097677007624	Walker A/P-loop; other site
1097677007625	ATP binding site [chemical binding]; other site
1097677007626	Q-loop/lid; other site
1097677007627	ABC transporter signature motif; other site
1097677007628	Walker B; other site
1097677007629	D-loop; other site
1097677007630	H-loop/switch region; other site
1097677007631	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1097677007632	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1097677007633	Histidine kinase; Region: HisKA_3; pfam07730
1097677007634	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1097677007635	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097677007636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677007637	active site
1097677007638	phosphorylation site [posttranslational modification]
1097677007639	intermolecular recognition site; other site
1097677007640	dimerization interface [polypeptide binding]; other site
1097677007641	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097677007642	DNA binding residues [nucleotide binding]
1097677007643	dimerization interface [polypeptide binding]; other site
1097677007644	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1097677007645	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097677007646	motif II; other site
1097677007647	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
1097677007648	GAF domain; Region: GAF; pfam01590
1097677007649	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
1097677007650	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1097677007651	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1097677007652	hypothetical protein; Provisional; Region: PRK10621
1097677007653	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1097677007654	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097677007655	non-specific DNA binding site [nucleotide binding]; other site
1097677007656	salt bridge; other site
1097677007657	sequence-specific DNA binding site [nucleotide binding]; other site
1097677007658	HipA N-terminal domain; Region: Couple_hipA; pfam13657
1097677007659	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
1097677007660	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1097677007661	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1097677007662	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
1097677007663	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1097677007664	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1097677007665	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1097677007666	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
1097677007667	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1097677007668	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1097677007669	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1097677007670	Ligand Binding Site [chemical binding]; other site
1097677007671	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097677007672	dimer interface [polypeptide binding]; other site
1097677007673	phosphorylation site [posttranslational modification]
1097677007674	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097677007675	ATP binding site [chemical binding]; other site
1097677007676	Mg2+ binding site [ion binding]; other site
1097677007677	G-X-G motif; other site
1097677007678	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
1097677007679	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677007680	active site
1097677007681	phosphorylation site [posttranslational modification]
1097677007682	intermolecular recognition site; other site
1097677007683	dimerization interface [polypeptide binding]; other site
1097677007684	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097677007685	DNA binding site [nucleotide binding]
1097677007686	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
1097677007687	active site
1097677007688	catalytic triad [active]
1097677007689	oxyanion hole [active]
1097677007690	RDD family; Region: RDD; pfam06271
1097677007691	DNA repair protein RadA; Provisional; Region: PRK11823
1097677007692	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1097677007693	Walker A motif; other site
1097677007694	ATP binding site [chemical binding]; other site
1097677007695	Walker B motif; other site
1097677007696	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1097677007697	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097677007698	dimerization interface [polypeptide binding]; other site
1097677007699	putative DNA binding site [nucleotide binding]; other site
1097677007700	putative Zn2+ binding site [ion binding]; other site
1097677007701	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097677007702	Coenzyme A binding pocket [chemical binding]; other site
1097677007703	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097677007704	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097677007705	dimer interface [polypeptide binding]; other site
1097677007706	phosphorylation site [posttranslational modification]
1097677007707	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097677007708	ATP binding site [chemical binding]; other site
1097677007709	Mg2+ binding site [ion binding]; other site
1097677007710	G-X-G motif; other site
1097677007711	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097677007712	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677007713	active site
1097677007714	phosphorylation site [posttranslational modification]
1097677007715	intermolecular recognition site; other site
1097677007716	dimerization interface [polypeptide binding]; other site
1097677007717	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097677007718	DNA binding site [nucleotide binding]
1097677007719	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1097677007720	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
1097677007721	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1097677007722	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1097677007723	Metal-binding active site; metal-binding site
1097677007724	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1097677007725	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1097677007726	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1097677007727	Walker A/P-loop; other site
1097677007728	ATP binding site [chemical binding]; other site
1097677007729	Q-loop/lid; other site
1097677007730	ABC transporter signature motif; other site
1097677007731	Walker B; other site
1097677007732	D-loop; other site
1097677007733	H-loop/switch region; other site
1097677007734	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1097677007735	putative FMN binding site [chemical binding]; other site
1097677007736	NADPH bind site [chemical binding]; other site
1097677007737	YcaO-like family; Region: YcaO; pfam02624
1097677007738	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
1097677007739	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
1097677007740	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
1097677007741	Cmm ortholog CMM_2778; Cms ortholog CMS_2627
1097677007742	Cmm ortholog CMM_2785; Cms ortholog CMS_2626
1097677007743	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1097677007744	mRNA/rRNA interface [nucleotide binding]; other site
1097677007745	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1097677007746	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1097677007747	23S rRNA interface [nucleotide binding]; other site
1097677007748	L7/L12 interface [polypeptide binding]; other site
1097677007749	putative thiostrepton binding site; other site
1097677007750	L25 interface [polypeptide binding]; other site
1097677007751	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1097677007752	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1097677007753	putative homodimer interface [polypeptide binding]; other site
1097677007754	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1097677007755	heterodimer interface [polypeptide binding]; other site
1097677007756	homodimer interface [polypeptide binding]; other site
1097677007757	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1097677007758	aspartate aminotransferase; Provisional; Region: PRK05764
1097677007759	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097677007760	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677007761	homodimer interface [polypeptide binding]; other site
1097677007762	catalytic residue [active]
1097677007763	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
1097677007764	FAD binding domain; Region: FAD_binding_4; pfam01565
1097677007765	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1097677007766	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
1097677007767	active site
1097677007768	catalytic site [active]
1097677007769	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1097677007770	active site
1097677007771	catalytic site [active]
1097677007772	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097677007773	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097677007774	active site
1097677007775	catalytic tetrad [active]
1097677007776	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
1097677007777	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1097677007778	active site
1097677007779	catalytic site [active]
1097677007780	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1097677007781	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1097677007782	Peptidase family M23; Region: Peptidase_M23; pfam01551
1097677007783	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1097677007784	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1097677007785	active site
1097677007786	dimerization interface [polypeptide binding]; other site
1097677007787	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1097677007788	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1097677007789	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097677007790	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097677007791	active site
1097677007792	catalytic tetrad [active]
1097677007793	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1097677007794	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1097677007795	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1097677007796	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
1097677007797	putative active site [active]
1097677007798	catalytic site [active]
1097677007799	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
1097677007800	putative active site [active]
1097677007801	catalytic site [active]
1097677007802	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097677007803	MarR family; Region: MarR; pfam01047
1097677007804	ferredoxin-NADP+ reductase; Region: PLN02852
1097677007805	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097677007806	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1097677007807	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1097677007808	substrate binding pocket [chemical binding]; other site
1097677007809	chain length determination region; other site
1097677007810	substrate-Mg2+ binding site; other site
1097677007811	catalytic residues [active]
1097677007812	aspartate-rich region 1; other site
1097677007813	active site lid residues [active]
1097677007814	aspartate-rich region 2; other site
1097677007815	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1097677007816	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097677007817	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1097677007818	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1097677007819	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1097677007820	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1097677007821	dimer interface [polypeptide binding]; other site
1097677007822	tetramer interface [polypeptide binding]; other site
1097677007823	PYR/PP interface [polypeptide binding]; other site
1097677007824	TPP binding site [chemical binding]; other site
1097677007825	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1097677007826	TPP-binding site; other site
1097677007827	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
1097677007828	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1097677007829	UbiA prenyltransferase family; Region: UbiA; pfam01040
1097677007832	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1097677007833	catalytic core [active]
1097677007834	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1097677007835	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1097677007836	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1097677007837	active site
1097677007838	Zn binding site [ion binding]; other site
1097677007839	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1097677007840	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097677007841	non-specific DNA binding site [nucleotide binding]; other site
1097677007842	salt bridge; other site
1097677007843	sequence-specific DNA binding site [nucleotide binding]; other site
1097677007844	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
1097677007845	Isochorismatase family; Region: Isochorismatase; pfam00857
1097677007846	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1097677007847	catalytic triad [active]
1097677007848	conserved cis-peptide bond; other site
1097677007849	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1097677007850	Na binding site [ion binding]; other site
1097677007851	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097677007852	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097677007853	DNA-binding site [nucleotide binding]; DNA binding site
1097677007854	FCD domain; Region: FCD; pfam07729
1097677007855	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1097677007856	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097677007857	motif II; other site
1097677007858	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097677007859	MarR family; Region: MarR_2; cl17246
1097677007860	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1097677007861	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
1097677007862	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1097677007863	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677007864	NAD(P) binding site [chemical binding]; other site
1097677007865	active site
1097677007866	Predicted transcriptional regulators [Transcription]; Region: COG1733
1097677007867	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1097677007868	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097677007869	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097677007870	active site
1097677007871	catalytic tetrad [active]
1097677007872	Domain of unknown function (DUF202); Region: DUF202; cl09954
1097677007873	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677007874	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1097677007875	NAD(P) binding site [chemical binding]; other site
1097677007876	active site
1097677007877	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1097677007878	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1097677007879	substrate binding site [chemical binding]; other site
1097677007880	ATP binding site [chemical binding]; other site
1097677007881	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097677007882	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097677007883	DNA binding site [nucleotide binding]
1097677007884	domain linker motif; other site
1097677007885	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1097677007886	dimerization interface [polypeptide binding]; other site
1097677007887	ligand binding site [chemical binding]; other site
1097677007888	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1097677007889	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1097677007890	ligand binding site [chemical binding]; other site
1097677007891	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097677007892	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097677007893	TM-ABC transporter signature motif; other site
1097677007894	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097677007895	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097677007896	Walker A/P-loop; other site
1097677007897	ATP binding site [chemical binding]; other site
1097677007898	Q-loop/lid; other site
1097677007899	ABC transporter signature motif; other site
1097677007900	Walker B; other site
1097677007901	D-loop; other site
1097677007902	H-loop/switch region; other site
1097677007903	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1097677007904	short chain dehydrogenase; Provisional; Region: PRK06172
1097677007905	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677007906	NAD(P) binding site [chemical binding]; other site
1097677007907	active site
1097677007908	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
1097677007909	DNA polymerase III subunit epsilon; Validated; Region: PRK06195
1097677007910	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1097677007911	active site
1097677007912	catalytic site [active]
1097677007913	substrate binding site [chemical binding]; other site
1097677007914	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1097677007915	Dimer interface [polypeptide binding]; other site
1097677007916	BRCT sequence motif; other site
1097677007917	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
1097677007918	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097677007919	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097677007920	putative DNA binding site [nucleotide binding]; other site
1097677007921	putative Zn2+ binding site [ion binding]; other site
1097677007922	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
1097677007923	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097677007924	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1097677007925	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1097677007926	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1097677007927	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097677007928	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097677007929	active site
1097677007930	catalytic tetrad [active]
1097677007931	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1097677007932	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
1097677007933	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1097677007934	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097677007935	S-adenosylmethionine binding site [chemical binding]; other site
1097677007936	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1097677007937	Cmm ortholog CMM_2862; Cms ortholog CMS_2190
1097677007938	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1097677007939	EamA-like transporter family; Region: EamA; pfam00892
1097677007940	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1097677007941	hypothetical protein; Provisional; Region: PRK03298
1097677007942	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
1097677007943	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1097677007944	DXD motif; other site
1097677007945	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1097677007946	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097677007947	motif II; other site
1097677007948	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097677007949	MarR family; Region: MarR; pfam01047
1097677007950	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
1097677007951	diiron binding motif [ion binding]; other site
1097677007952	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
1097677007953	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1097677007954	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097677007955	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1097677007956	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
1097677007957	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1097677007958	inhibitor-cofactor binding pocket; inhibition site
1097677007959	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677007960	catalytic residue [active]
1097677007961	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1097677007962	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097677007963	active site
1097677007964	phosphorylation site [posttranslational modification]
1097677007965	intermolecular recognition site; other site
1097677007966	dimerization interface [polypeptide binding]; other site
1097677007967	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
1097677007968	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1097677007969	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097677007970	ATP binding site [chemical binding]; other site
1097677007971	Mg2+ binding site [ion binding]; other site
1097677007972	G-X-G motif; other site
1097677007973	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
1097677007974	Citrate transporter; Region: CitMHS; pfam03600
1097677007975	Citrate transporter; Region: CitMHS; pfam03600
1097677007976	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
1097677007977	Predicted membrane protein [Function unknown]; Region: COG3463
1097677007978	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
1097677007979	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097677007980	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097677007981	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097677007982	dimerization interface [polypeptide binding]; other site
1097677007983	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1097677007984	active site
1097677007985	oxyanion hole [active]
1097677007986	catalytic triad [active]
1097677007987	prenyltransferase; Reviewed; Region: ubiA; PRK13105
1097677007988	UbiA prenyltransferase family; Region: UbiA; pfam01040
1097677007989	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
1097677007990	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
1097677007991	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1097677007992	active site lid residues [active]
1097677007993	substrate binding pocket [chemical binding]; other site
1097677007994	catalytic residues [active]
1097677007995	substrate-Mg2+ binding site; other site
1097677007996	aspartate-rich region 1; other site
1097677007997	aspartate-rich region 2; other site
1097677007998	phytoene desaturase; Region: crtI_fam; TIGR02734
1097677007999	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1097677008000	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1097677008001	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1097677008002	substrate binding pocket [chemical binding]; other site
1097677008003	chain length determination region; other site
1097677008004	substrate-Mg2+ binding site; other site
1097677008005	catalytic residues [active]
1097677008006	aspartate-rich region 1; other site
1097677008007	active site lid residues [active]
1097677008008	aspartate-rich region 2; other site
1097677008009	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
1097677008010	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
1097677008011	active site
1097677008012	metal binding site [ion binding]; metal-binding site
1097677008013	nudix motif; other site
1097677008014	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1097677008015	nucleophile elbow; other site
1097677008016	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
1097677008017	oligomer interface [polypeptide binding]; other site
1097677008018	Cmm ortholog CMM_2862; Cms ortholog CMS_2190
1097677008019	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1097677008020	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1097677008021	hexamer interface [polypeptide binding]; other site
1097677008022	ligand binding site [chemical binding]; other site
1097677008023	putative active site [active]
1097677008024	NAD(P) binding site [chemical binding]; other site
1097677008025	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1097677008026	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1097677008027	AsnC family; Region: AsnC_trans_reg; pfam01037
1097677008028	Predicted transcriptional regulators [Transcription]; Region: COG1733
1097677008029	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1097677008030	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1097677008031	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097677008032	NAD(P) binding site [chemical binding]; other site
1097677008033	active site
1097677008034	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1097677008035	trimer interface [polypeptide binding]; other site
1097677008036	active site
1097677008037	AAA domain; Region: AAA_13; pfam13166
1097677008038	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097677008039	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097677008040	DNA-binding site [nucleotide binding]; DNA binding site
1097677008041	FCD domain; Region: FCD; pfam07729
1097677008042	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1097677008043	AAA domain; Region: AAA_33; pfam13671
1097677008044	ATP-binding site [chemical binding]; other site
1097677008045	Gluconate-6-phosphate binding site [chemical binding]; other site
1097677008046	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1097677008047	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1097677008048	Cmm ortholog CMM_2909; no Cms ortholog
1097677008049	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1097677008050	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
1097677008051	putative DNA binding site [nucleotide binding]; other site
1097677008052	catalytic residue [active]
1097677008053	putative H2TH interface [polypeptide binding]; other site
1097677008054	putative catalytic residues [active]
1097677008055	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1097677008056	coenzyme F420 hydrogenase, subunit alpha; Region: frhA; TIGR03295
1097677008057	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1097677008058	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
1097677008059	classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370
1097677008060	putative NAD(P) binding site [chemical binding]; other site
1097677008061	active site
1097677008062	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097677008063	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097677008064	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1097677008065	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1097677008066	Predicted flavoprotein [General function prediction only]; Region: COG0431
1097677008067	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1097677008068	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1097677008069	NAD binding site [chemical binding]; other site
1097677008070	catalytic Zn binding site [ion binding]; other site
1097677008071	structural Zn binding site [ion binding]; other site
1097677008072	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1097677008073	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1097677008074	dimanganese center [ion binding]; other site
1097677008075	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1097677008076	intersubunit interface [polypeptide binding]; other site
1097677008077	active site
1097677008078	catalytic residue [active]
1097677008079	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
1097677008080	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
1097677008081	active site
1097677008082	metal binding site [ion binding]; metal-binding site
1097677008083	Domain of unknown function (DUF305); Region: DUF305; cl17794
1097677008084	Domain of unknown function (DUF305); Region: DUF305; cl17794
1097677008085	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1097677008086	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
1097677008087	PIF1-like helicase; Region: PIF1; pfam05970
1097677008088	AAA domain; Region: AAA_30; pfam13604
1097677008089	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1097677008090	dimer interface [polypeptide binding]; other site
1097677008091	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097677008092	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1097677008093	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1097677008094	Walker A/P-loop; other site
1097677008095	ATP binding site [chemical binding]; other site
1097677008096	Q-loop/lid; other site
1097677008097	ABC transporter signature motif; other site
1097677008098	Walker B; other site
1097677008099	D-loop; other site
1097677008100	H-loop/switch region; other site
1097677008101	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1097677008102	ABC-ATPase subunit  interface; other site
1097677008103	dimer interface [polypeptide binding]; other site
1097677008104	putative PBP binding regions; other site
1097677008105	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1097677008106	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1097677008107	ABC-ATPase subunit  interface; other site
1097677008108	dimer interface [polypeptide binding]; other site
1097677008109	putative PBP binding regions; other site
1097677008110	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1097677008111	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1097677008112	siderophore binding site; other site
1097677008113	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097677008114	putative DNA binding site [nucleotide binding]; other site
1097677008115	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097677008116	putative Zn2+ binding site [ion binding]; other site
1097677008117	Protein of unknown function (DUF998); Region: DUF998; pfam06197
1097677008118	Predicted membrane protein [Function unknown]; Region: COG3371
1097677008119	Copper resistance protein D; Region: CopD; cl00563
1097677008120	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
1097677008121	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1097677008122	IHF dimer interface [polypeptide binding]; other site
1097677008123	IHF - DNA interface [nucleotide binding]; other site
1097677008124	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1097677008125	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1097677008126	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1097677008127	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1097677008128	metal binding site 2 [ion binding]; metal-binding site
1097677008129	putative DNA binding helix; other site
1097677008130	metal binding site 1 [ion binding]; metal-binding site
1097677008131	dimer interface [polypeptide binding]; other site
1097677008132	structural Zn2+ binding site [ion binding]; other site
1097677008133	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1097677008134	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1097677008135	putative PBP binding regions; other site
1097677008136	ABC-ATPase subunit  interface; other site
1097677008137	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1097677008138	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097677008139	Walker A/P-loop; other site
1097677008140	ATP binding site [chemical binding]; other site
1097677008141	Q-loop/lid; other site
1097677008142	ABC transporter signature motif; other site
1097677008143	Walker B; other site
1097677008144	D-loop; other site
1097677008145	H-loop/switch region; other site
1097677008146	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1097677008147	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1097677008148	intersubunit interface [polypeptide binding]; other site
1097677008149	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1097677008150	E3 interaction surface; other site
1097677008151	lipoyl attachment site [posttranslational modification]; other site
1097677008152	e3 binding domain; Region: E3_binding; pfam02817
1097677008153	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
1097677008154	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1097677008155	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1097677008156	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1097677008157	alpha subunit interface [polypeptide binding]; other site
1097677008158	TPP binding site [chemical binding]; other site
1097677008159	heterodimer interface [polypeptide binding]; other site
1097677008160	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1097677008161	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1097677008162	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1097677008163	TPP-binding site [chemical binding]; other site
1097677008164	tetramer interface [polypeptide binding]; other site
1097677008165	heterodimer interface [polypeptide binding]; other site
1097677008166	phosphorylation loop region [posttranslational modification]
1097677008167	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
1097677008168	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097677008169	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677008170	homodimer interface [polypeptide binding]; other site
1097677008171	catalytic residue [active]
1097677008172	Membrane protein of unknown function; Region: DUF360; pfam04020
1097677008173	PGAP1-like protein; Region: PGAP1; pfam07819
1097677008174	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1097677008175	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1097677008176	active site
1097677008177	adenylosuccinate lyase; Provisional; Region: PRK09285
1097677008178	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1097677008179	tetramer interface [polypeptide binding]; other site
1097677008180	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1097677008181	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1097677008182	nucleotide binding site [chemical binding]; other site
1097677008183	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1097677008184	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
1097677008185	putative ADP-binding pocket [chemical binding]; other site
1097677008186	helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422
1097677008187	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1097677008188	DNA binding residues [nucleotide binding]
1097677008189	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
1097677008190	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1097677008191	G1 box; other site
1097677008192	putative GEF interaction site [polypeptide binding]; other site
1097677008193	GTP/Mg2+ binding site [chemical binding]; other site
1097677008194	Switch I region; other site
1097677008195	G2 box; other site
1097677008196	G3 box; other site
1097677008197	Switch II region; other site
1097677008198	G4 box; other site
1097677008199	G5 box; other site
1097677008200	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1097677008201	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
1097677008202	CHY zinc finger; Region: zf-CHY; pfam05495
1097677008203	replicative DNA helicase; Region: DnaB; TIGR00665
1097677008204	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1097677008205	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1097677008206	Walker A motif; other site
1097677008207	ATP binding site [chemical binding]; other site
1097677008208	Walker B motif; other site
1097677008209	DNA binding loops [nucleotide binding]
1097677008210	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1097677008211	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1097677008212	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1097677008213	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1097677008214	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1097677008215	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1097677008216	dimer interface [polypeptide binding]; other site
1097677008217	ssDNA binding site [nucleotide binding]; other site
1097677008218	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1097677008219	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1097677008220	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
1097677008221	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1097677008222	active site
1097677008223	NTP binding site [chemical binding]; other site
1097677008224	metal binding triad [ion binding]; metal-binding site
1097677008225	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1097677008226	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1097677008227	Zn2+ binding site [ion binding]; other site
1097677008228	Mg2+ binding site [ion binding]; other site
1097677008229	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1097677008230	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1097677008231	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097677008232	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097677008233	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1097677008234	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1097677008235	catalytic residues [active]
1097677008236	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1097677008237	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097677008238	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097677008239	homodimer interface [polypeptide binding]; other site
1097677008240	catalytic residue [active]
1097677008241	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
1097677008242	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1097677008243	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1097677008244	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1097677008245	ParB-like nuclease domain; Region: ParBc; pfam02195
1097677008246	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1097677008247	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097677008248	Magnesium ion binding site [ion binding]; other site
1097677008249	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097677008250	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1097677008251	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
1097677008252	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1097677008253	G-X-X-G motif; other site
1097677008254	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1097677008255	RxxxH motif; other site
1097677008256	putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315
1097677008257	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1097677008258	hypothetical protein; Provisional; Region: PRK14378
1097677008259	Ribonuclease P; Region: Ribonuclease_P; pfam00825
1097677008260	Ribosomal protein L34; Region: Ribosomal_L34; cl00370