-- dump date 20140619_042508 -- class Genbank::misc_feature -- table misc_feature_note -- id note 863638000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 863638000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 863638000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638000004 Walker A motif; other site 863638000005 ATP binding site [chemical binding]; other site 863638000006 Walker B motif; other site 863638000007 arginine finger; other site 863638000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 863638000009 DnaA box-binding interface [nucleotide binding]; other site 863638000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 863638000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 863638000012 putative DNA binding surface [nucleotide binding]; other site 863638000013 dimer interface [polypeptide binding]; other site 863638000014 beta-clamp/clamp loader binding surface; other site 863638000015 beta-clamp/translesion DNA polymerase binding surface; other site 863638000016 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 863638000017 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 863638000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 863638000019 Walker A/P-loop; other site 863638000020 ATP binding site [chemical binding]; other site 863638000021 Q-loop/lid; other site 863638000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638000023 ABC transporter signature motif; other site 863638000024 Walker B; other site 863638000025 D-loop; other site 863638000026 H-loop/switch region; other site 863638000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 863638000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638000029 ATP binding site [chemical binding]; other site 863638000030 Mg2+ binding site [ion binding]; other site 863638000031 G-X-G motif; other site 863638000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 863638000033 anchoring element; other site 863638000034 dimer interface [polypeptide binding]; other site 863638000035 ATP binding site [chemical binding]; other site 863638000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 863638000037 active site 863638000038 putative metal-binding site [ion binding]; other site 863638000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 863638000040 DNA gyrase subunit A; Validated; Region: PRK05560 863638000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 863638000042 CAP-like domain; other site 863638000043 active site 863638000044 primary dimer interface [polypeptide binding]; other site 863638000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 863638000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 863638000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 863638000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 863638000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 863638000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 863638000051 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 863638000052 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 863638000053 HTH domain; Region: HTH_11; pfam08279 863638000054 3H domain; Region: 3H; pfam02829 863638000055 hypothetical protein; Validated; Region: PRK00068 863638000056 Uncharacterized conserved protein [Function unknown]; Region: COG1615 863638000057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 863638000058 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 863638000059 Predicted dehydrogenase [General function prediction only]; Region: COG0579 863638000060 hydroxyglutarate oxidase; Provisional; Region: PRK11728 863638000061 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 863638000062 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 863638000063 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 863638000064 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 863638000065 catalytic residue [active] 863638000066 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 863638000067 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 863638000068 putative ligand binding site [chemical binding]; other site 863638000069 NAD binding site [chemical binding]; other site 863638000070 dimerization interface [polypeptide binding]; other site 863638000071 catalytic site [active] 863638000072 Uncharacterized conserved protein [Function unknown]; Region: COG4198 863638000073 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 863638000074 seryl-tRNA synthetase; Provisional; Region: PRK05431 863638000075 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 863638000076 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 863638000077 dimer interface [polypeptide binding]; other site 863638000078 active site 863638000079 motif 1; other site 863638000080 motif 2; other site 863638000081 motif 3; other site 863638000082 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 863638000083 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 863638000084 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638000085 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638000086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638000087 Major Facilitator Superfamily; Region: MFS_1; pfam07690 863638000088 putative substrate translocation pore; other site 863638000089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638000090 Predicted membrane protein [Function unknown]; Region: COG1511 863638000091 seryl-tRNA synthetase; Provisional; Region: PRK05431 863638000092 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 863638000093 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 863638000094 dimer interface [polypeptide binding]; other site 863638000095 active site 863638000096 motif 1; other site 863638000097 motif 2; other site 863638000098 motif 3; other site 863638000099 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 863638000100 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 863638000101 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 863638000102 Transcriptional regulator [Transcription]; Region: LysR; COG0583 863638000103 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 863638000104 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 863638000105 dimerization interface [polypeptide binding]; other site 863638000106 Predicted membrane protein [Function unknown]; Region: COG4713 863638000107 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 863638000108 trimer interface [polypeptide binding]; other site 863638000109 active site 863638000110 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 863638000111 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 863638000112 active site 863638000113 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 863638000114 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 863638000115 catalytic loop [active] 863638000116 iron binding site [ion binding]; other site 863638000117 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 863638000118 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 863638000119 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 863638000120 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 863638000121 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 863638000122 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638000123 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638000124 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 863638000125 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 863638000126 ABC1 family; Region: ABC1; cl17513 863638000127 Uncharacterized conserved protein [Function unknown]; Region: COG3937 863638000128 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 863638000129 active site 863638000130 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 863638000131 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 863638000132 phosphopeptide binding site; other site 863638000133 AAA domain; Region: AAA_31; pfam13614 863638000134 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 863638000135 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 863638000136 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 863638000137 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 863638000138 phosphopeptide binding site; other site 863638000139 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 863638000140 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 863638000141 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 863638000142 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 863638000143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 863638000144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 863638000145 TPR repeat; Region: TPR_11; pfam13414 863638000146 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638000147 binding surface 863638000148 TPR motif; other site 863638000149 TPR repeat; Region: TPR_11; pfam13414 863638000150 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638000151 binding surface 863638000152 TPR motif; other site 863638000153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638000154 binding surface 863638000155 TPR motif; other site 863638000156 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 863638000157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4332 863638000158 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 863638000159 Phage-related protein [Function unknown]; Region: COG4722 863638000160 putative phage tail component, N-terminal domain; Region: phi3626_gp14_N; TIGR01633 863638000161 Phage-related protein [Function unknown]; Region: PblB; COG4926 863638000162 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 863638000163 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638000164 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 863638000165 Walker A/P-loop; other site 863638000166 ATP binding site [chemical binding]; other site 863638000167 Q-loop/lid; other site 863638000168 ABC transporter signature motif; other site 863638000169 Walker B; other site 863638000170 D-loop; other site 863638000171 H-loop/switch region; other site 863638000172 FtsX-like permease family; Region: FtsX; pfam02687 863638000173 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 863638000174 Hemerythrin; Region: Hemerythrin; cd12107 863638000175 Fe binding site [ion binding]; other site 863638000176 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 863638000177 Regulator of cell morphogenesis and NO signaling [Cell division and chromosome partitioning]; Region: COG2846 863638000178 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 863638000179 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 863638000180 Uncharacterized conserved protein [Function unknown]; Region: COG4309 863638000181 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 863638000182 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 863638000183 potential frameshift: common BLAST hit: gi|302390348|ref|YP_003826169.1| major facilitator superfamily protein 863638000184 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 863638000185 dimerization interface [polypeptide binding]; other site 863638000186 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 863638000187 EamA-like transporter family; Region: EamA; pfam00892 863638000188 EamA-like transporter family; Region: EamA; pfam00892 863638000189 CAAX protease self-immunity; Region: Abi; pfam02517 863638000190 putative accessory gene regulator protein; Provisional; Region: PRK01100 863638000191 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 863638000192 potential frameshift: common BLAST hit: gi|337735289|ref|YP_004634736.1| histidine kinase-like ATPase 863638000193 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 863638000194 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 863638000195 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 863638000196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638000197 active site 863638000198 phosphorylation site [posttranslational modification] 863638000199 intermolecular recognition site; other site 863638000200 dimerization interface [polypeptide binding]; other site 863638000201 LytTr DNA-binding domain; Region: LytTR; pfam04397 863638000202 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 863638000203 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 863638000204 active site 863638000205 zinc binding site [ion binding]; other site 863638000206 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 863638000207 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 863638000208 putative active site [active] 863638000209 nucleotide binding site [chemical binding]; other site 863638000210 nudix motif; other site 863638000211 putative metal binding site [ion binding]; other site 863638000212 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 863638000213 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 863638000214 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 863638000215 methionine sulfoxide reductase A; Provisional; Region: PRK14054 863638000216 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 863638000217 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_1; cd12161 863638000218 putative ligand binding site [chemical binding]; other site 863638000219 putative NAD binding site [chemical binding]; other site 863638000220 catalytic site [active] 863638000221 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 863638000222 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 863638000223 NodB motif; other site 863638000224 active site 863638000225 catalytic site [active] 863638000226 Zn binding site [ion binding]; other site 863638000227 ketol-acid reductoisomerase; Provisional; Region: PRK05479 863638000228 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 863638000229 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 863638000230 Predicted membrane protein [Function unknown]; Region: COG2707 863638000231 Transcriptional regulator [Transcription]; Region: LysR; COG0583 863638000232 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 863638000233 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 863638000234 putative dimerization interface [polypeptide binding]; other site 863638000235 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 863638000236 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 863638000237 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 863638000238 Glutamyl-tRNA reductase [Coenzyme metabolism]; Region: HemA; COG0373 863638000239 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 863638000240 tRNA; other site 863638000241 putative tRNA binding site [nucleotide binding]; other site 863638000242 putative NADP binding site [chemical binding]; other site 863638000243 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 863638000244 precorrin-2 dehydrogenase; Provisional; Region: PRK05562 863638000245 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 863638000246 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 863638000247 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 863638000248 domain interfaces; other site 863638000249 active site 863638000250 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 863638000251 active site 863638000252 SAM binding site [chemical binding]; other site 863638000253 homodimer interface [polypeptide binding]; other site 863638000254 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 863638000255 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 863638000256 active site 863638000257 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 863638000258 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 863638000259 inhibitor-cofactor binding pocket; inhibition site 863638000260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638000261 catalytic residue [active] 863638000262 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 863638000263 dimer interface [polypeptide binding]; other site 863638000264 active site 863638000265 Schiff base residues; other site 863638000266 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 863638000267 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 863638000268 homodimer interface [polypeptide binding]; other site 863638000269 substrate-cofactor binding pocket; other site 863638000270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638000271 catalytic residue [active] 863638000272 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 863638000273 AAA domain; Region: AAA_18; pfam13238 863638000274 ligand-binding site [chemical binding]; other site 863638000275 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 863638000276 L-aspartate oxidase; Provisional; Region: PRK06175 863638000277 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 863638000278 Ferredoxin [Energy production and conversion]; Region: COG1146 863638000279 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 863638000280 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 863638000281 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 863638000282 substrate binding pocket [chemical binding]; other site 863638000283 membrane-bound complex binding site; other site 863638000284 hinge residues; other site 863638000285 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 863638000286 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 863638000287 Walker A/P-loop; other site 863638000288 ATP binding site [chemical binding]; other site 863638000289 Q-loop/lid; other site 863638000290 ABC transporter signature motif; other site 863638000291 Walker B; other site 863638000292 D-loop; other site 863638000293 H-loop/switch region; other site 863638000294 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 863638000295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638000296 dimer interface [polypeptide binding]; other site 863638000297 conserved gate region; other site 863638000298 putative PBP binding loops; other site 863638000299 ABC-ATPase subunit interface; other site 863638000300 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 863638000301 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 863638000302 Active Sites [active] 863638000303 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 863638000304 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 863638000305 CysD dimerization site [polypeptide binding]; other site 863638000306 G1 box; other site 863638000307 putative GEF interaction site [polypeptide binding]; other site 863638000308 GTP/Mg2+ binding site [chemical binding]; other site 863638000309 Switch I region; other site 863638000310 G2 box; other site 863638000311 G3 box; other site 863638000312 Switch II region; other site 863638000313 G4 box; other site 863638000314 G5 box; other site 863638000315 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 863638000316 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 863638000317 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 863638000318 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 863638000319 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 863638000320 substrate binding pocket [chemical binding]; other site 863638000321 membrane-bound complex binding site; other site 863638000322 hinge residues; other site 863638000323 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 863638000324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638000325 dimer interface [polypeptide binding]; other site 863638000326 conserved gate region; other site 863638000327 putative PBP binding loops; other site 863638000328 ABC-ATPase subunit interface; other site 863638000329 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 863638000330 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 863638000331 Walker A/P-loop; other site 863638000332 ATP binding site [chemical binding]; other site 863638000333 Q-loop/lid; other site 863638000334 ABC transporter signature motif; other site 863638000335 Walker B; other site 863638000336 D-loop; other site 863638000337 H-loop/switch region; other site 863638000338 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 863638000339 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 863638000340 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 863638000341 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 863638000342 Rrf2 family protein; Region: rrf2_super; TIGR00738 863638000343 Transcriptional regulator; Region: Rrf2; pfam02082 863638000344 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 863638000345 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 863638000346 ACS interaction site; other site 863638000347 CODH interaction site; other site 863638000348 cubane metal cluster (B-cluster) [ion binding]; other site 863638000349 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 863638000350 Response regulator receiver domain; Region: Response_reg; pfam00072 863638000351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638000352 active site 863638000353 phosphorylation site [posttranslational modification] 863638000354 intermolecular recognition site; other site 863638000355 dimerization interface [polypeptide binding]; other site 863638000356 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 863638000357 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 863638000358 putative binding surface; other site 863638000359 active site 863638000360 P2 response regulator binding domain; Region: P2; pfam07194 863638000361 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 863638000362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638000363 ATP binding site [chemical binding]; other site 863638000364 Mg2+ binding site [ion binding]; other site 863638000365 G-X-G motif; other site 863638000366 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 863638000367 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 863638000368 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 863638000369 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 863638000370 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638000371 dimerization interface [polypeptide binding]; other site 863638000372 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638000373 dimer interface [polypeptide binding]; other site 863638000374 putative CheW interface [polypeptide binding]; other site 863638000375 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 863638000376 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 863638000377 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 863638000378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638000379 active site 863638000380 phosphorylation site [posttranslational modification] 863638000381 intermolecular recognition site; other site 863638000382 dimerization interface [polypeptide binding]; other site 863638000383 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 863638000384 nucleoside/Zn binding site; other site 863638000385 dimer interface [polypeptide binding]; other site 863638000386 catalytic motif [active] 863638000387 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 863638000388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638000389 Walker B motif; other site 863638000390 arginine finger; other site 863638000391 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 863638000392 hypothetical protein; Validated; Region: PRK00153 863638000393 recombination protein RecR; Reviewed; Region: recR; PRK00076 863638000394 RecR protein; Region: RecR; pfam02132 863638000395 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 863638000396 putative active site [active] 863638000397 putative metal-binding site [ion binding]; other site 863638000398 tetramer interface [polypeptide binding]; other site 863638000399 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 863638000400 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 863638000401 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 863638000402 Domain of unknown function DUF; Region: DUF204; pfam02659 863638000403 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 863638000404 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 863638000405 Walker A/P-loop; other site 863638000406 ATP binding site [chemical binding]; other site 863638000407 Q-loop/lid; other site 863638000408 ABC transporter signature motif; other site 863638000409 Walker B; other site 863638000410 D-loop; other site 863638000411 H-loop/switch region; other site 863638000412 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 863638000413 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 863638000414 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 863638000415 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 863638000416 HlyD family secretion protein; Region: HlyD_3; pfam13437 863638000417 DNA-binding protein, stimulates sugar fermentation [General function prediction only]; Region: SfsA; COG1489 863638000418 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 863638000419 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 863638000420 putative NADH binding site [chemical binding]; other site 863638000421 putative active site [active] 863638000422 nudix motif; other site 863638000423 putative metal binding site [ion binding]; other site 863638000424 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 863638000425 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 863638000426 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 863638000427 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 863638000428 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 863638000429 Walker A/P-loop; other site 863638000430 ATP binding site [chemical binding]; other site 863638000431 Q-loop/lid; other site 863638000432 ABC transporter signature motif; other site 863638000433 Walker B; other site 863638000434 D-loop; other site 863638000435 H-loop/switch region; other site 863638000436 Class I aldolases; Region: Aldolase_Class_I; cl17187 863638000437 Class I aldolases; Region: Aldolase_Class_I; cl17187 863638000438 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 863638000439 Methyltransferase domain; Region: Methyltransf_31; pfam13847 863638000440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638000441 S-adenosylmethionine binding site [chemical binding]; other site 863638000442 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 863638000443 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 863638000444 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 863638000445 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 863638000446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638000447 motif II; other site 863638000448 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 863638000449 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 863638000450 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 863638000451 active site 863638000452 P-loop; other site 863638000453 phosphorylation site [posttranslational modification] 863638000454 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 863638000455 PRD domain; Region: PRD; pfam00874 863638000456 PRD domain; Region: PRD; pfam00874 863638000457 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 863638000458 active site 863638000459 P-loop; other site 863638000460 phosphorylation site [posttranslational modification] 863638000461 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 863638000462 active site 863638000463 phosphorylation site [posttranslational modification] 863638000464 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 863638000465 active site 863638000466 phosphorylation site [posttranslational modification] 863638000467 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 863638000468 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 863638000469 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 863638000470 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 863638000471 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 863638000472 glutaminase active site [active] 863638000473 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 863638000474 dimer interface [polypeptide binding]; other site 863638000475 active site 863638000476 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 863638000477 dimer interface [polypeptide binding]; other site 863638000478 active site 863638000479 TIGR04076 family protein; Region: TIGR04076 863638000480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638000481 Coenzyme A binding pocket [chemical binding]; other site 863638000482 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 863638000483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638000484 Transcriptional regulators [Transcription]; Region: MarR; COG1846 863638000485 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 863638000486 putative Zn2+ binding site [ion binding]; other site 863638000487 putative DNA binding site [nucleotide binding]; other site 863638000488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638000489 Coenzyme A binding pocket [chemical binding]; other site 863638000490 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638000491 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 863638000492 Walker A/P-loop; other site 863638000493 ATP binding site [chemical binding]; other site 863638000494 Q-loop/lid; other site 863638000495 ABC transporter signature motif; other site 863638000496 Walker B; other site 863638000497 D-loop; other site 863638000498 H-loop/switch region; other site 863638000499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1978 863638000500 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 863638000501 catalytic core [active] 863638000502 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 863638000503 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 863638000504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638000505 Walker A/P-loop; other site 863638000506 ATP binding site [chemical binding]; other site 863638000507 Q-loop/lid; other site 863638000508 ABC transporter signature motif; other site 863638000509 Walker B; other site 863638000510 D-loop; other site 863638000511 H-loop/switch region; other site 863638000512 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 863638000513 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 863638000514 ABC-2 type transporter; Region: ABC2_membrane; cl17235 863638000515 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 863638000516 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 863638000517 Histidine kinase; Region: HisKA_3; pfam07730 863638000518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 863638000519 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 863638000520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638000521 active site 863638000522 phosphorylation site [posttranslational modification] 863638000523 intermolecular recognition site; other site 863638000524 dimerization interface [polypeptide binding]; other site 863638000525 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 863638000526 DNA binding residues [nucleotide binding] 863638000527 dimerization interface [polypeptide binding]; other site 863638000528 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 863638000529 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 863638000530 putative active site [active] 863638000531 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 863638000532 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 863638000533 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 863638000534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638000535 dimer interface [polypeptide binding]; other site 863638000536 conserved gate region; other site 863638000537 putative PBP binding loops; other site 863638000538 ABC-ATPase subunit interface; other site 863638000539 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 863638000540 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 863638000541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638000542 dimer interface [polypeptide binding]; other site 863638000543 conserved gate region; other site 863638000544 putative PBP binding loops; other site 863638000545 ABC-ATPase subunit interface; other site 863638000546 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 863638000547 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 863638000548 Walker A/P-loop; other site 863638000549 ATP binding site [chemical binding]; other site 863638000550 Q-loop/lid; other site 863638000551 ABC transporter signature motif; other site 863638000552 Walker B; other site 863638000553 D-loop; other site 863638000554 H-loop/switch region; other site 863638000555 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 863638000556 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 863638000557 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 863638000558 Walker A/P-loop; other site 863638000559 ATP binding site [chemical binding]; other site 863638000560 Q-loop/lid; other site 863638000561 ABC transporter signature motif; other site 863638000562 Walker B; other site 863638000563 D-loop; other site 863638000564 H-loop/switch region; other site 863638000565 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 863638000566 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 863638000567 Beta-lactamase; Region: Beta-lactamase; pfam00144 863638000568 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 863638000569 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 863638000570 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 863638000571 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 863638000572 nucleotide binding site [chemical binding]; other site 863638000573 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638000574 Coenzyme A binding pocket [chemical binding]; other site 863638000575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638000576 Coenzyme A binding pocket [chemical binding]; other site 863638000577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 863638000578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638000579 non-specific DNA binding site [nucleotide binding]; other site 863638000580 salt bridge; other site 863638000581 sequence-specific DNA binding site [nucleotide binding]; other site 863638000582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638000583 binding surface 863638000584 TPR motif; other site 863638000585 Tetratricopeptide repeat; Region: TPR_12; pfam13424 863638000586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638000587 binding surface 863638000588 Tetratricopeptide repeat; Region: TPR_12; pfam13424 863638000589 TPR motif; other site 863638000590 Tetratricopeptide repeat; Region: TPR_12; pfam13424 863638000591 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 863638000592 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 863638000593 active site 863638000594 trimer interface [polypeptide binding]; other site 863638000595 allosteric site; other site 863638000596 active site lid [active] 863638000597 hexamer (dimer of trimers) interface [polypeptide binding]; other site 863638000598 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 863638000599 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 863638000600 active site 863638000601 dimer interface [polypeptide binding]; other site 863638000602 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 863638000603 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 863638000604 DNA-binding site [nucleotide binding]; DNA binding site 863638000605 UTRA domain; Region: UTRA; pfam07702 863638000606 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 863638000607 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 863638000608 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 863638000609 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 863638000610 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 863638000611 putative active site [active] 863638000612 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 863638000613 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 863638000614 active site 863638000615 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 863638000616 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 863638000617 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 863638000618 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 863638000619 Ligand binding site; other site 863638000620 Putative Catalytic site; other site 863638000621 DXD motif; other site 863638000622 Predicted transcriptional regulators [Transcription]; Region: COG1733 863638000623 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 863638000624 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 863638000625 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 863638000626 active site 863638000627 FMN binding site [chemical binding]; other site 863638000628 substrate binding site [chemical binding]; other site 863638000629 putative catalytic residue [active] 863638000630 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 863638000631 MarR family; Region: MarR; pfam01047 863638000632 Predicted membrane protein [Function unknown]; Region: COG2364 863638000633 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 863638000634 Predicted membrane protein [Function unknown]; Region: COG2717 863638000635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638000636 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638000637 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 863638000638 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 863638000639 flavodoxin; Provisional; Region: PRK06242 863638000640 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166 863638000641 active site 863638000642 catalytic site [active] 863638000643 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 863638000644 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 863638000645 active site 863638000646 metal binding site [ion binding]; metal-binding site 863638000647 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 863638000648 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 863638000649 biotin synthase; Region: bioB; TIGR00433 863638000650 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638000651 FeS/SAM binding site; other site 863638000652 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 863638000653 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 863638000654 Biotin operon repressor [Transcription]; Region: BirA; COG1654 863638000655 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 863638000656 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 863638000657 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 863638000658 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 863638000659 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 863638000660 oligomer interface [polypeptide binding]; other site 863638000661 active site 863638000662 metal binding site [ion binding]; metal-binding site 863638000663 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 863638000664 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 863638000665 oligomer interface [polypeptide binding]; other site 863638000666 active site 863638000667 metal binding site [ion binding]; metal-binding site 863638000668 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 863638000669 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 863638000670 metal binding site [ion binding]; metal-binding site 863638000671 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 863638000672 Prephenate dehydratase; Region: PDT; pfam00800 863638000673 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 863638000674 putative L-Phe binding site [chemical binding]; other site 863638000675 Integral membrane protein TerC family; Region: TerC; cl10468 863638000676 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 863638000677 active site 863638000678 Fe-S cluster binding site [ion binding]; other site 863638000679 Clostripain family; Region: Peptidase_C11; pfam03415 863638000680 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 863638000681 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 863638000682 catalytic residue [active] 863638000683 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 863638000684 active site 863638000685 putative catalytic site [active] 863638000686 DNA binding site [nucleotide binding] 863638000687 putative phosphate binding site [ion binding]; other site 863638000688 metal binding site A [ion binding]; metal-binding site 863638000689 AP binding site [nucleotide binding]; other site 863638000690 metal binding site B [ion binding]; metal-binding site 863638000691 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 863638000692 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 863638000693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 863638000694 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638000695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638000696 active site 863638000697 phosphorylation site [posttranslational modification] 863638000698 intermolecular recognition site; other site 863638000699 dimerization interface [polypeptide binding]; other site 863638000700 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638000701 DNA binding site [nucleotide binding] 863638000702 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638000703 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 863638000704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638000705 ATP binding site [chemical binding]; other site 863638000706 Mg2+ binding site [ion binding]; other site 863638000707 G-X-G motif; other site 863638000708 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638000709 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 863638000710 Walker A/P-loop; other site 863638000711 ATP binding site [chemical binding]; other site 863638000712 Q-loop/lid; other site 863638000713 ABC transporter signature motif; other site 863638000714 Walker B; other site 863638000715 D-loop; other site 863638000716 H-loop/switch region; other site 863638000717 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 863638000718 FtsX-like permease family; Region: FtsX; pfam02687 863638000719 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 863638000720 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 863638000721 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 863638000722 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 863638000723 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 863638000724 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 863638000725 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 863638000726 putative substrate binding site [chemical binding]; other site 863638000727 putative ATP binding site [chemical binding]; other site 863638000728 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 863638000729 active site 863638000730 phosphorylation site [posttranslational modification] 863638000731 potential frameshift: common BLAST hit: gi|337735445|ref|YP_004634892.1| PTS system, fructoso-specific IIBC component 863638000732 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 863638000733 active site 863638000734 P-loop; other site 863638000735 phosphorylation site [posttranslational modification] 863638000736 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 863638000737 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 863638000738 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 863638000739 Chloramphenicol acetyltransferase; Region: CAT; smart01059 863638000740 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 863638000741 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638000742 Walker A/P-loop; other site 863638000743 ATP binding site [chemical binding]; other site 863638000744 Q-loop/lid; other site 863638000745 ABC transporter signature motif; other site 863638000746 Walker B; other site 863638000747 D-loop; other site 863638000748 H-loop/switch region; other site 863638000749 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 863638000750 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 863638000751 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 863638000752 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 863638000753 Histidine kinase; Region: HisKA_3; pfam07730 863638000754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638000755 ATP binding site [chemical binding]; other site 863638000756 Mg2+ binding site [ion binding]; other site 863638000757 G-X-G motif; other site 863638000758 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 863638000759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638000760 active site 863638000761 phosphorylation site [posttranslational modification] 863638000762 intermolecular recognition site; other site 863638000763 dimerization interface [polypeptide binding]; other site 863638000764 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 863638000765 DNA binding residues [nucleotide binding] 863638000766 dimerization interface [polypeptide binding]; other site 863638000767 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 863638000768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638000769 Walker A/P-loop; other site 863638000770 ATP binding site [chemical binding]; other site 863638000771 Q-loop/lid; other site 863638000772 ABC transporter signature motif; other site 863638000773 Walker B; other site 863638000774 D-loop; other site 863638000775 H-loop/switch region; other site 863638000776 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 863638000777 ABC-2 type transporter; Region: ABC2_membrane; cl17235 863638000778 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 863638000779 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 863638000780 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 863638000781 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 863638000782 FtsX-like permease family; Region: FtsX; pfam02687 863638000783 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638000784 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 863638000785 Walker A/P-loop; other site 863638000786 ATP binding site [chemical binding]; other site 863638000787 Q-loop/lid; other site 863638000788 ABC transporter signature motif; other site 863638000789 Walker B; other site 863638000790 D-loop; other site 863638000791 H-loop/switch region; other site 863638000792 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 863638000793 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 863638000794 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 863638000795 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 863638000796 putative metal binding site [ion binding]; other site 863638000797 Cache domain; Region: Cache_1; pfam02743 863638000798 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 863638000799 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638000800 dimer interface [polypeptide binding]; other site 863638000801 putative CheW interface [polypeptide binding]; other site 863638000802 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 863638000803 Helix-turn-helix domain; Region: HTH_17; pfam12728 863638000804 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 863638000805 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 863638000806 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 863638000807 Nucleotide-binding sites [chemical binding]; other site 863638000808 Walker A motif; other site 863638000809 Switch I region of nucleotide binding site; other site 863638000810 Fe4S4 binding sites [ion binding]; other site 863638000811 Switch II region of nucleotide binding site; other site 863638000812 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 863638000813 Nitrogen regulatory protein P-II; Region: P-II; smart00938 863638000814 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 863638000815 Nitrogen regulatory protein P-II; Region: P-II; smart00938 863638000816 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 863638000817 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 863638000818 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 863638000819 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 863638000820 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 863638000821 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 863638000822 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 863638000823 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 863638000824 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 863638000825 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638000826 FeS/SAM binding site; other site 863638000827 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 863638000828 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 863638000829 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 863638000830 metal binding site [ion binding]; metal-binding site 863638000831 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 863638000832 active site 863638000833 catalytic residues [active] 863638000834 metal binding site [ion binding]; metal-binding site 863638000835 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 863638000836 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 863638000837 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638000838 motif II; other site 863638000839 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 863638000840 Predicted transcriptional regulators [Transcription]; Region: COG1725 863638000841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 863638000842 DNA-binding site [nucleotide binding]; DNA binding site 863638000843 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 863638000844 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 863638000845 Walker A/P-loop; other site 863638000846 ATP binding site [chemical binding]; other site 863638000847 Q-loop/lid; other site 863638000848 ABC transporter signature motif; other site 863638000849 Walker B; other site 863638000850 D-loop; other site 863638000851 H-loop/switch region; other site 863638000852 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 863638000853 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 863638000854 NAD binding site [chemical binding]; other site 863638000855 dimer interface [polypeptide binding]; other site 863638000856 substrate binding site [chemical binding]; other site 863638000857 tetramer (dimer of dimers) interface [polypeptide binding]; other site 863638000858 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 863638000859 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 863638000860 Walker A/P-loop; other site 863638000861 ATP binding site [chemical binding]; other site 863638000862 Q-loop/lid; other site 863638000863 ABC transporter signature motif; other site 863638000864 Walker B; other site 863638000865 D-loop; other site 863638000866 H-loop/switch region; other site 863638000867 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 863638000868 active site 863638000869 Amino acid permease; Region: AA_permease_2; pfam13520 863638000870 2-isopropylmalate synthase; Validated; Region: PRK03739 863638000871 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 863638000872 active site 863638000873 catalytic residues [active] 863638000874 metal binding site [ion binding]; metal-binding site 863638000875 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 863638000876 aspartate ammonia-lyase; Provisional; Region: PRK13353 863638000877 Aspartase; Region: Aspartase; cd01357 863638000878 active sites [active] 863638000879 tetramer interface [polypeptide binding]; other site 863638000880 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 863638000881 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638000882 Zn2+ binding site [ion binding]; other site 863638000883 Mg2+ binding site [ion binding]; other site 863638000884 aspartate kinase; Reviewed; Region: PRK09034 863638000885 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 863638000886 putative catalytic residues [active] 863638000887 putative nucleotide binding site [chemical binding]; other site 863638000888 putative aspartate binding site [chemical binding]; other site 863638000889 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 863638000890 allosteric regulatory residue; other site 863638000891 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 863638000892 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 863638000893 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 863638000894 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 863638000895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638000896 putative PBP binding loops; other site 863638000897 ABC-ATPase subunit interface; other site 863638000898 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 863638000899 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 863638000900 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 863638000901 guanine deaminase; Region: guan_deamin; TIGR02967 863638000902 active site 863638000903 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 863638000904 MPT binding site; other site 863638000905 trimer interface [polypeptide binding]; other site 863638000906 NAD-dependent deacetylase; Provisional; Region: PRK00481 863638000907 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 863638000908 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 863638000909 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 863638000910 active site 863638000911 DNA binding site [nucleotide binding] 863638000912 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 863638000913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 863638000914 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 863638000915 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 863638000916 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 863638000917 Walker A/P-loop; other site 863638000918 ATP binding site [chemical binding]; other site 863638000919 Q-loop/lid; other site 863638000920 ABC transporter signature motif; other site 863638000921 Walker B; other site 863638000922 D-loop; other site 863638000923 H-loop/switch region; other site 863638000924 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638000925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638000926 active site 863638000927 phosphorylation site [posttranslational modification] 863638000928 intermolecular recognition site; other site 863638000929 dimerization interface [polypeptide binding]; other site 863638000930 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638000931 DNA binding site [nucleotide binding] 863638000932 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638000933 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638000934 dimer interface [polypeptide binding]; other site 863638000935 phosphorylation site [posttranslational modification] 863638000936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638000937 ATP binding site [chemical binding]; other site 863638000938 Mg2+ binding site [ion binding]; other site 863638000939 G-X-G motif; other site 863638000940 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 863638000941 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 863638000942 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 863638000943 FAD binding site [chemical binding]; other site 863638000944 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 863638000945 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 863638000946 dimer interface [polypeptide binding]; other site 863638000947 catalytic triad [active] 863638000948 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 863638000949 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 863638000950 Cl binding site [ion binding]; other site 863638000951 oligomer interface [polypeptide binding]; other site 863638000952 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 863638000953 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 863638000954 metal binding site [ion binding]; metal-binding site 863638000955 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 863638000956 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 863638000957 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 863638000958 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 863638000959 homodimer interface [polypeptide binding]; other site 863638000960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638000961 catalytic residue [active] 863638000962 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 863638000963 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 863638000964 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 863638000965 active site 863638000966 Protein of unknown function (DUF970); Region: DUF970; pfam06153 863638000967 DNA polymerase III subunit delta'; Validated; Region: PRK05564 863638000968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638000969 Walker A motif; other site 863638000970 ATP binding site [chemical binding]; other site 863638000971 Walker B motif; other site 863638000972 arginine finger; other site 863638000973 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 863638000974 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 863638000975 metal-binding site [ion binding] 863638000976 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 863638000977 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 863638000978 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 863638000979 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 863638000980 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 863638000981 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 863638000982 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 863638000983 ligand binding site [chemical binding]; other site 863638000984 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 863638000985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638000986 S-adenosylmethionine binding site [chemical binding]; other site 863638000987 Predicted methyltransferases [General function prediction only]; Region: COG0313 863638000988 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 863638000989 putative SAM binding site [chemical binding]; other site 863638000990 putative homodimer interface [polypeptide binding]; other site 863638000991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 863638000992 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 863638000993 NlpC/P60 family; Region: NLPC_P60; pfam00877 863638000994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 863638000995 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 863638000996 NlpC/P60 family; Region: NLPC_P60; pfam00877 863638000997 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 863638000998 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 863638000999 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 863638001000 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 863638001001 active site 863638001002 NTP binding site [chemical binding]; other site 863638001003 metal binding triad [ion binding]; metal-binding site 863638001004 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 863638001005 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 863638001006 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 863638001007 Predicted acetyltransferase [General function prediction only]; Region: COG3981 863638001008 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 863638001009 ornithine carbamoyltransferase; Validated; Region: PRK02102 863638001010 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 863638001011 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 863638001012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638001013 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638001014 dimerization interface [polypeptide binding]; other site 863638001015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638001016 dimer interface [polypeptide binding]; other site 863638001017 phosphorylation site [posttranslational modification] 863638001018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638001019 ATP binding site [chemical binding]; other site 863638001020 G-X-G motif; other site 863638001021 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 863638001022 HlyD family secretion protein; Region: HlyD_3; pfam13437 863638001023 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 863638001024 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638001025 Walker A/P-loop; other site 863638001026 ATP binding site [chemical binding]; other site 863638001027 Q-loop/lid; other site 863638001028 ABC transporter signature motif; other site 863638001029 Walker B; other site 863638001030 D-loop; other site 863638001031 H-loop/switch region; other site 863638001032 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 863638001033 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 863638001034 FtsX-like permease family; Region: FtsX; pfam02687 863638001035 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638001036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638001037 active site 863638001038 phosphorylation site [posttranslational modification] 863638001039 intermolecular recognition site; other site 863638001040 dimerization interface [polypeptide binding]; other site 863638001041 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638001042 DNA binding site [nucleotide binding] 863638001043 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 863638001044 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 863638001045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638001046 dimer interface [polypeptide binding]; other site 863638001047 phosphorylation site [posttranslational modification] 863638001048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638001049 ATP binding site [chemical binding]; other site 863638001050 Mg2+ binding site [ion binding]; other site 863638001051 G-X-G motif; other site 863638001052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638001053 non-specific DNA binding site [nucleotide binding]; other site 863638001054 salt bridge; other site 863638001055 sequence-specific DNA binding site [nucleotide binding]; other site 863638001056 Predicted membrane protein [Function unknown]; Region: COG1971 863638001057 recombination factor protein RarA; Reviewed; Region: PRK13342 863638001058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638001059 Walker A motif; other site 863638001060 ATP binding site [chemical binding]; other site 863638001061 Walker B motif; other site 863638001062 arginine finger; other site 863638001063 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 863638001064 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 863638001065 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 863638001066 catalytic triad [active] 863638001067 Protein of unknown function DUF45; Region: DUF45; pfam01863 863638001068 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 863638001069 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 863638001070 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 863638001071 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 863638001072 Predicted membrane protein [Function unknown]; Region: COG4684 863638001073 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 863638001074 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 863638001075 LXG domain of WXG superfamily; Region: LXG; pfam04740 863638001076 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 863638001077 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 863638001078 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 863638001079 Immunity protein Imm6; Region: Imm6; pfam14434 863638001080 Immunity protein Imm6; Region: Imm6; pfam14434 863638001081 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 863638001082 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cd00233 863638001083 active site 863638001084 conformational flexibility of ligand binding pocket; other site 863638001085 ADP-ribosylating toxin turn-turn motif; other site 863638001086 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 863638001087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4304 863638001088 Uncharacterized conserved protein [Function unknown]; Region: COG1434 863638001089 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 863638001090 putative active site [active] 863638001091 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 863638001092 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 863638001093 active site 863638001094 metal binding site [ion binding]; metal-binding site 863638001095 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 863638001096 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 863638001097 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 863638001098 active site 863638001099 metal binding site [ion binding]; metal-binding site 863638001100 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 863638001101 Predicted integral membrane protein [Function unknown]; Region: COG5542 863638001102 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 863638001103 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 863638001104 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 863638001105 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 863638001106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638001107 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 863638001108 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 863638001109 putative active site [active] 863638001110 putative metal binding site [ion binding]; other site 863638001111 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 863638001112 Transcriptional regulators [Transcription]; Region: PurR; COG1609 863638001113 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 863638001114 DNA binding site [nucleotide binding] 863638001115 domain linker motif; other site 863638001116 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 863638001117 dimerization interface [polypeptide binding]; other site 863638001118 ligand binding site [chemical binding]; other site 863638001119 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 863638001120 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 863638001121 NADP binding site [chemical binding]; other site 863638001122 homodimer interface [polypeptide binding]; other site 863638001123 active site 863638001124 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 863638001125 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 863638001126 Active_site [active] 863638001127 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 863638001128 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 863638001129 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 863638001130 putative ligand binding site [chemical binding]; other site 863638001131 NAD binding site [chemical binding]; other site 863638001132 catalytic site [active] 863638001133 Membrane transport protein; Region: Mem_trans; pfam03547 863638001134 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 863638001135 putative metal binding site [ion binding]; other site 863638001136 putative dimer interface [polypeptide binding]; other site 863638001137 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 863638001138 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 863638001139 inhibitor-cofactor binding pocket; inhibition site 863638001140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638001141 catalytic residue [active] 863638001142 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 863638001143 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 863638001144 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 863638001145 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 863638001146 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638001147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638001148 active site 863638001149 phosphorylation site [posttranslational modification] 863638001150 intermolecular recognition site; other site 863638001151 dimerization interface [polypeptide binding]; other site 863638001152 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 863638001153 DNA binding site [nucleotide binding] 863638001154 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638001155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638001156 ATP binding site [chemical binding]; other site 863638001157 Mg2+ binding site [ion binding]; other site 863638001158 G-X-G motif; other site 863638001159 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638001160 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 863638001161 Walker A/P-loop; other site 863638001162 ATP binding site [chemical binding]; other site 863638001163 Q-loop/lid; other site 863638001164 ABC transporter signature motif; other site 863638001165 Walker B; other site 863638001166 D-loop; other site 863638001167 H-loop/switch region; other site 863638001168 aminotransferase A; Validated; Region: PRK07683 863638001169 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 863638001170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638001171 homodimer interface [polypeptide binding]; other site 863638001172 catalytic residue [active] 863638001173 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 863638001174 Amidinotransferase; Region: Amidinotransf; pfam02274 863638001175 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 863638001176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638001177 dimer interface [polypeptide binding]; other site 863638001178 conserved gate region; other site 863638001179 putative PBP binding loops; other site 863638001180 ABC-ATPase subunit interface; other site 863638001181 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 863638001182 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 863638001183 Walker A/P-loop; other site 863638001184 ATP binding site [chemical binding]; other site 863638001185 Q-loop/lid; other site 863638001186 ABC transporter signature motif; other site 863638001187 Walker B; other site 863638001188 D-loop; other site 863638001189 H-loop/switch region; other site 863638001190 Transcriptional regulators [Transcription]; Region: GntR; COG1802 863638001191 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 863638001192 DNA-binding site [nucleotide binding]; DNA binding site 863638001193 FCD domain; Region: FCD; pfam07729 863638001194 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 863638001195 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 863638001196 substrate binding pocket [chemical binding]; other site 863638001197 membrane-bound complex binding site; other site 863638001198 hinge residues; other site 863638001199 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638001200 dimer interface [polypeptide binding]; other site 863638001201 putative CheW interface [polypeptide binding]; other site 863638001202 Adenosine deaminase z-alpha domain; Region: z-alpha; cl02659 863638001203 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 863638001204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638001205 Walker A motif; other site 863638001206 ATP binding site [chemical binding]; other site 863638001207 Walker B motif; other site 863638001208 arginine finger; other site 863638001209 Transcriptional antiterminator [Transcription]; Region: COG3933 863638001210 PRD domain; Region: PRD; pfam00874 863638001211 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 863638001212 active pocket/dimerization site; other site 863638001213 active site 863638001214 phosphorylation site [posttranslational modification] 863638001215 PRD domain; Region: PRD; pfam00874 863638001216 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 863638001217 active site 863638001218 methionine cluster; other site 863638001219 phosphorylation site [posttranslational modification] 863638001220 metal binding site [ion binding]; metal-binding site 863638001221 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 863638001222 active site 863638001223 P-loop; other site 863638001224 phosphorylation site [posttranslational modification] 863638001225 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 863638001226 beta-galactosidase; Region: BGL; TIGR03356 863638001227 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 863638001228 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 863638001229 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 863638001230 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 863638001231 homodimer interface [polypeptide binding]; other site 863638001232 substrate-cofactor binding pocket; other site 863638001233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638001234 catalytic residue [active] 863638001235 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 863638001236 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 863638001237 homodimer interface [polypeptide binding]; other site 863638001238 substrate-cofactor binding pocket; other site 863638001239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638001240 catalytic residue [active] 863638001241 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 863638001242 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 863638001243 Transcriptional regulators [Transcription]; Region: PurR; COG1609 863638001244 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 863638001245 DNA binding site [nucleotide binding] 863638001246 domain linker motif; other site 863638001247 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 863638001248 putative dimerization interface [polypeptide binding]; other site 863638001249 putative ligand binding site [chemical binding]; other site 863638001250 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 863638001251 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 863638001252 active site 863638001253 intersubunit interface [polypeptide binding]; other site 863638001254 catalytic residue [active] 863638001255 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 863638001256 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 863638001257 substrate binding site [chemical binding]; other site 863638001258 ATP binding site [chemical binding]; other site 863638001259 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 863638001260 active site 863638001261 dimer interface [polypeptide binding]; other site 863638001262 magnesium binding site [ion binding]; other site 863638001263 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 863638001264 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 863638001265 tetramer interface [polypeptide binding]; other site 863638001266 active site 863638001267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 863638001268 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 863638001269 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 863638001270 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 863638001271 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 863638001272 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 863638001273 Protein kinase domain; Region: Pkinase; pfam00069 863638001274 active site 863638001275 ATP binding site [chemical binding]; other site 863638001276 substrate binding site [chemical binding]; other site 863638001277 activation loop (A-loop); other site 863638001278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638001279 TPR motif; other site 863638001280 binding surface 863638001281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638001282 binding surface 863638001283 TPR motif; other site 863638001284 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 863638001285 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 863638001286 phosphopeptide binding site; other site 863638001287 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 863638001288 active site 863638001289 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 863638001290 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 863638001291 phosphopeptide binding site; other site 863638001292 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 863638001293 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 863638001294 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 863638001295 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 863638001296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 863638001297 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 863638001298 TPR repeat; Region: TPR_11; pfam13414 863638001299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638001300 binding surface 863638001301 TPR motif; other site 863638001302 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638001303 binding surface 863638001304 TPR motif; other site 863638001305 TPR repeat; Region: TPR_11; pfam13414 863638001306 Tetratricopeptide repeat; Region: TPR_16; pfam13432 863638001307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638001308 binding surface 863638001309 TPR motif; other site 863638001310 TPR repeat; Region: TPR_11; pfam13414 863638001311 TPR repeat; Region: TPR_11; pfam13414 863638001312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 863638001313 TPR repeat; Region: TPR_11; pfam13414 863638001314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638001315 binding surface 863638001316 TPR motif; other site 863638001317 TPR repeat; Region: TPR_11; pfam13414 863638001318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638001319 binding surface 863638001320 TPR motif; other site 863638001321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638001322 TPR motif; other site 863638001323 binding surface 863638001324 TPR repeat; Region: TPR_11; pfam13414 863638001325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638001326 binding surface 863638001327 TPR motif; other site 863638001328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638001329 binding surface 863638001330 TPR motif; other site 863638001331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638001332 TPR repeat; Region: TPR_11; pfam13414 863638001333 binding surface 863638001334 TPR motif; other site 863638001335 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638001336 binding surface 863638001337 TPR motif; other site 863638001338 TPR repeat; Region: TPR_11; pfam13414 863638001339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638001340 binding surface 863638001341 TPR motif; other site 863638001342 TPR repeat; Region: TPR_11; pfam13414 863638001343 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638001344 binding surface 863638001345 TPR motif; other site 863638001346 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 863638001347 ArsC family; Region: ArsC; pfam03960 863638001348 catalytic residue [active] 863638001349 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 863638001350 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638001351 motif II; other site 863638001352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 863638001353 G-X-G motif; other site 863638001354 Transmembrane protein 55A; Region: Tmemb_55A; pfam09788 863638001355 CAAX protease self-immunity; Region: Abi; pfam02517 863638001356 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 863638001357 transcriptional antiterminator BglG; Provisional; Region: PRK09772 863638001358 CAT RNA binding domain; Region: CAT_RBD; smart01061 863638001359 PRD domain; Region: PRD; pfam00874 863638001360 PRD domain; Region: PRD; pfam00874 863638001361 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 863638001362 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 863638001363 active site turn [active] 863638001364 phosphorylation site [posttranslational modification] 863638001365 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 863638001366 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 863638001367 HPr interaction site; other site 863638001368 glycerol kinase (GK) interaction site [polypeptide binding]; other site 863638001369 active site 863638001370 phosphorylation site [posttranslational modification] 863638001371 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 863638001372 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 863638001373 putative substrate binding site [chemical binding]; other site 863638001374 putative ATP binding site [chemical binding]; other site 863638001375 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 863638001376 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 863638001377 substrate binding [chemical binding]; other site 863638001378 active site 863638001379 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 863638001380 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 863638001381 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 863638001382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 863638001383 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 863638001384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638001385 dimer interface [polypeptide binding]; other site 863638001386 conserved gate region; other site 863638001387 putative PBP binding loops; other site 863638001388 ABC-ATPase subunit interface; other site 863638001389 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 863638001390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638001391 dimer interface [polypeptide binding]; other site 863638001392 conserved gate region; other site 863638001393 putative PBP binding loops; other site 863638001394 ABC-ATPase subunit interface; other site 863638001395 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 863638001396 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 863638001397 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 863638001398 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 863638001399 active site 863638001400 catalytic site [active] 863638001401 metal binding site [ion binding]; metal-binding site 863638001402 dimer interface [polypeptide binding]; other site 863638001403 Uncharacterized conserved protein [Function unknown]; Region: COG1284 863638001404 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 863638001405 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 863638001406 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 863638001407 Sensory domain found in PocR; Region: PocR; pfam10114 863638001408 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 863638001409 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638001410 dimer interface [polypeptide binding]; other site 863638001411 putative CheW interface [polypeptide binding]; other site 863638001412 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 863638001413 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638001414 dimer interface [polypeptide binding]; other site 863638001415 putative CheW interface [polypeptide binding]; other site 863638001416 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 863638001417 homotrimer interaction site [polypeptide binding]; other site 863638001418 zinc binding site [ion binding]; other site 863638001419 CDP-binding sites; other site 863638001420 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 863638001421 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 863638001422 putative active site [active] 863638001423 putative metal binding site [ion binding]; other site 863638001424 PAS domain S-box; Region: sensory_box; TIGR00229 863638001425 PAS domain; Region: PAS_8; pfam13188 863638001426 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 863638001427 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638001428 dimer interface [polypeptide binding]; other site 863638001429 phosphorylation site [posttranslational modification] 863638001430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638001431 ATP binding site [chemical binding]; other site 863638001432 Mg2+ binding site [ion binding]; other site 863638001433 G-X-G motif; other site 863638001434 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 863638001435 BON domain; Region: BON; pfam04972 863638001436 BON domain; Region: BON; pfam04972 863638001437 Uncharacterized conserved protein [Function unknown]; Region: COG1434 863638001438 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 863638001439 putative active site [active] 863638001440 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 863638001441 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 863638001442 Cl- selectivity filter; other site 863638001443 Cl- binding residues [ion binding]; other site 863638001444 pore gating glutamate residue; other site 863638001445 dimer interface [polypeptide binding]; other site 863638001446 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 863638001447 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 863638001448 HAMP domain; Region: HAMP; pfam00672 863638001449 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638001450 dimer interface [polypeptide binding]; other site 863638001451 putative CheW interface [polypeptide binding]; other site 863638001452 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 863638001453 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 863638001454 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 863638001455 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 863638001456 DNA binding residues [nucleotide binding] 863638001457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3860 863638001458 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 863638001459 nudix motif; other site 863638001460 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 863638001461 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 863638001462 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 863638001463 G1 box; other site 863638001464 GTP/Mg2+ binding site [chemical binding]; other site 863638001465 Switch I region; other site 863638001466 G2 box; other site 863638001467 G3 box; other site 863638001468 Switch II region; other site 863638001469 G4 box; other site 863638001470 G5 box; other site 863638001471 Nucleoside recognition; Region: Gate; pfam07670 863638001472 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 863638001473 Nucleoside recognition; Region: Gate; pfam07670 863638001474 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 863638001475 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638001476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638001477 active site 863638001478 phosphorylation site [posttranslational modification] 863638001479 intermolecular recognition site; other site 863638001480 dimerization interface [polypeptide binding]; other site 863638001481 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638001482 DNA binding site [nucleotide binding] 863638001483 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638001484 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638001485 dimerization interface [polypeptide binding]; other site 863638001486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638001487 dimer interface [polypeptide binding]; other site 863638001488 phosphorylation site [posttranslational modification] 863638001489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638001490 ATP binding site [chemical binding]; other site 863638001491 Mg2+ binding site [ion binding]; other site 863638001492 G-X-G motif; other site 863638001493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638001494 putative substrate translocation pore; other site 863638001495 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638001496 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 863638001497 Walker A/P-loop; other site 863638001498 ATP binding site [chemical binding]; other site 863638001499 Q-loop/lid; other site 863638001500 ABC transporter signature motif; other site 863638001501 Walker B; other site 863638001502 D-loop; other site 863638001503 H-loop/switch region; other site 863638001504 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 863638001505 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 863638001506 FtsX-like permease family; Region: FtsX; pfam02687 863638001507 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 863638001508 FtsX-like permease family; Region: FtsX; pfam02687 863638001509 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 863638001510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638001511 Walker A motif; other site 863638001512 ATP binding site [chemical binding]; other site 863638001513 Walker B motif; other site 863638001514 arginine finger; other site 863638001515 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 863638001516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638001517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638001518 H+ Antiporter protein; Region: 2A0121; TIGR00900 863638001519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638001520 putative substrate translocation pore; other site 863638001521 Propionate catabolism activator; Region: PrpR_N; pfam06506 863638001522 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 863638001523 PAS domain; Region: PAS; smart00091 863638001524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638001525 Walker A motif; other site 863638001526 ATP binding site [chemical binding]; other site 863638001527 Walker B motif; other site 863638001528 arginine finger; other site 863638001529 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 863638001530 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 863638001531 Domain of unknown function DUF21; Region: DUF21; pfam01595 863638001532 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 863638001533 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 863638001534 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 863638001535 DNA binding residues [nucleotide binding] 863638001536 dimer interface [polypeptide binding]; other site 863638001537 metal binding site [ion binding]; metal-binding site 863638001538 Uncharacterized paraquat-inducible protein B [Function unknown]; Region: COG3007 863638001539 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 863638001540 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 863638001541 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 863638001542 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 863638001543 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 863638001544 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 863638001545 protein binding site [polypeptide binding]; other site 863638001546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 863638001547 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 863638001548 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638001549 non-specific DNA binding site [nucleotide binding]; other site 863638001550 salt bridge; other site 863638001551 sequence-specific DNA binding site [nucleotide binding]; other site 863638001552 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 863638001553 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 863638001554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638001555 motif II; other site 863638001556 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 863638001557 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 863638001558 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 863638001559 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 863638001560 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 863638001561 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 863638001562 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 863638001563 nucleotide binding site [chemical binding]; other site 863638001564 putative NEF/HSP70 interaction site [polypeptide binding]; other site 863638001565 SBD interface [polypeptide binding]; other site 863638001566 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 863638001567 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 863638001568 nucleotide binding site [chemical binding]; other site 863638001569 putative NEF/HSP70 interaction site [polypeptide binding]; other site 863638001570 SBD interface [polypeptide binding]; other site 863638001571 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 863638001572 metal ion-dependent adhesion site (MIDAS); other site 863638001573 Double zinc ribbon; Region: DZR; pfam12773 863638001574 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 863638001575 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638001576 Zn2+ binding site [ion binding]; other site 863638001577 Mg2+ binding site [ion binding]; other site 863638001578 peptidase T; Region: peptidase-T; TIGR01882 863638001579 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 863638001580 metal binding site [ion binding]; metal-binding site 863638001581 dimer interface [polypeptide binding]; other site 863638001582 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 863638001583 Uncharacterized conserved protein [Function unknown]; Region: COG3379 863638001584 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 863638001585 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 863638001586 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 863638001587 ATP cone domain; Region: ATP-cone; pfam03477 863638001588 Class III ribonucleotide reductase; Region: RNR_III; cd01675 863638001589 effector binding site; other site 863638001590 active site 863638001591 Zn binding site [ion binding]; other site 863638001592 glycine loop; other site 863638001593 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 863638001594 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638001595 FeS/SAM binding site; other site 863638001596 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 863638001597 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 863638001598 CAAX protease self-immunity; Region: Abi; pfam02517 863638001599 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 863638001600 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 863638001601 active site 863638001602 substrate binding site [chemical binding]; other site 863638001603 metal binding site [ion binding]; metal-binding site 863638001604 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 863638001605 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 863638001606 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 863638001607 Uncharacterized conserved protein [Function unknown]; Region: COG0062 863638001608 putative carbohydrate kinase; Provisional; Region: PRK10565 863638001609 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 863638001610 putative substrate binding site [chemical binding]; other site 863638001611 putative ATP binding site [chemical binding]; other site 863638001612 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 863638001613 alanine racemase; Reviewed; Region: alr; PRK00053 863638001614 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 863638001615 active site 863638001616 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 863638001617 dimer interface [polypeptide binding]; other site 863638001618 substrate binding site [chemical binding]; other site 863638001619 catalytic residues [active] 863638001620 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 863638001621 PemK-like protein; Region: PemK; pfam02452 863638001622 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 863638001623 thiamine phosphate binding site [chemical binding]; other site 863638001624 active site 863638001625 pyrophosphate binding site [ion binding]; other site 863638001626 Uncharacterized conserved protein [Function unknown]; Region: COG1284 863638001627 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 863638001628 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 863638001629 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 863638001630 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 863638001631 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 863638001632 Walker A/P-loop; other site 863638001633 ATP binding site [chemical binding]; other site 863638001634 Q-loop/lid; other site 863638001635 ABC transporter signature motif; other site 863638001636 Walker B; other site 863638001637 D-loop; other site 863638001638 H-loop/switch region; other site 863638001639 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 863638001640 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 863638001641 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 863638001642 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 863638001643 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 863638001644 protein binding site [polypeptide binding]; other site 863638001645 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 863638001646 Catalytic dyad [active] 863638001647 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 863638001648 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 863638001649 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 863638001650 excinuclease ABC subunit B; Provisional; Region: PRK05298 863638001651 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 863638001652 ATP binding site [chemical binding]; other site 863638001653 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 863638001654 putative Mg++ binding site [ion binding]; other site 863638001655 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 863638001656 nucleotide binding region [chemical binding]; other site 863638001657 ATP-binding site [chemical binding]; other site 863638001658 Ultra-violet resistance protein B; Region: UvrB; pfam12344 863638001659 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 863638001660 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 863638001661 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 863638001662 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 863638001663 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 863638001664 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 863638001665 phosphopeptide binding site; other site 863638001666 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 863638001667 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 863638001668 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 863638001669 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 863638001670 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 863638001671 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 863638001672 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 863638001673 GIY-YIG motif/motif A; other site 863638001674 active site 863638001675 catalytic site [active] 863638001676 putative DNA binding site [nucleotide binding]; other site 863638001677 metal binding site [ion binding]; metal-binding site 863638001678 UvrB/uvrC motif; Region: UVR; pfam02151 863638001679 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 863638001680 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 863638001681 putative hydrolase; Validated; Region: PRK09248 863638001682 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 863638001683 active site 863638001684 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 863638001685 FAD binding domain; Region: FAD_binding_4; pfam01565 863638001686 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 863638001687 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 863638001688 AAA domain; Region: AAA_18; pfam13238 863638001689 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 863638001690 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 863638001691 phosphate binding site [ion binding]; other site 863638001692 putative substrate binding pocket [chemical binding]; other site 863638001693 dimer interface [polypeptide binding]; other site 863638001694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 863638001695 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 863638001696 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 863638001697 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 863638001698 DNA-binding site [nucleotide binding]; DNA binding site 863638001699 DRTGG domain; Region: DRTGG; pfam07085 863638001700 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 863638001701 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 863638001702 active site 2 [active] 863638001703 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 863638001704 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 863638001705 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 863638001706 active site 863638001707 PHP Thumb interface [polypeptide binding]; other site 863638001708 metal binding site [ion binding]; metal-binding site 863638001709 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 863638001710 generic binding surface II; other site 863638001711 generic binding surface I; other site 863638001712 6-phosphofructokinase; Provisional; Region: PRK03202 863638001713 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 863638001714 active site 863638001715 ADP/pyrophosphate binding site [chemical binding]; other site 863638001716 dimerization interface [polypeptide binding]; other site 863638001717 allosteric effector site; other site 863638001718 fructose-1,6-bisphosphate binding site; other site 863638001719 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 863638001720 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 863638001721 domain interfaces; other site 863638001722 active site 863638001723 dihydroorotase; Validated; Region: pyrC; PRK09357 863638001724 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 863638001725 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 863638001726 active site 863638001727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 863638001728 NAD(P) binding site [chemical binding]; other site 863638001729 active site 863638001730 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 863638001731 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 863638001732 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 863638001733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638001734 active site 863638001735 motif I; other site 863638001736 motif II; other site 863638001737 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 863638001738 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 863638001739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638001740 S-adenosylmethionine binding site [chemical binding]; other site 863638001741 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638001742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638001743 active site 863638001744 phosphorylation site [posttranslational modification] 863638001745 intermolecular recognition site; other site 863638001746 dimerization interface [polypeptide binding]; other site 863638001747 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638001748 DNA binding site [nucleotide binding] 863638001749 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638001750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638001751 dimer interface [polypeptide binding]; other site 863638001752 phosphorylation site [posttranslational modification] 863638001753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638001754 ATP binding site [chemical binding]; other site 863638001755 Mg2+ binding site [ion binding]; other site 863638001756 G-X-G motif; other site 863638001757 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638001758 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 863638001759 Walker A/P-loop; other site 863638001760 ATP binding site [chemical binding]; other site 863638001761 Q-loop/lid; other site 863638001762 ABC transporter signature motif; other site 863638001763 Walker B; other site 863638001764 D-loop; other site 863638001765 H-loop/switch region; other site 863638001766 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 863638001767 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 863638001768 FtsX-like permease family; Region: FtsX; pfam02687 863638001769 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 863638001770 FtsX-like permease family; Region: FtsX; pfam02687 863638001771 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 863638001772 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 863638001773 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 863638001774 Domain of unknown function (DUF303); Region: DUF303; pfam03629 863638001775 Predicted transcriptional regulators [Transcription]; Region: COG1695 863638001776 Transcriptional regulator PadR-like family; Region: PadR; cl17335 863638001777 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 863638001778 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 863638001779 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 863638001780 putative active site [active] 863638001781 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 863638001782 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 863638001783 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 863638001784 active site turn [active] 863638001785 phosphorylation site [posttranslational modification] 863638001786 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 863638001787 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 863638001788 NAD binding site [chemical binding]; other site 863638001789 sugar binding site [chemical binding]; other site 863638001790 divalent metal binding site [ion binding]; other site 863638001791 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 863638001792 dimer interface [polypeptide binding]; other site 863638001793 phosphoenolpyruvate synthase; Validated; Region: PRK06241 863638001794 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 863638001795 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 863638001796 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 863638001797 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 863638001798 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 863638001799 putative NAD(P) binding site [chemical binding]; other site 863638001800 active site 863638001801 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 863638001802 active site 863638001803 catalytic triad [active] 863638001804 oxyanion hole [active] 863638001805 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 863638001806 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638001807 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638001808 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638001809 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638001810 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 863638001811 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638001812 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638001813 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638001814 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638001815 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 863638001816 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638001817 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638001818 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638001819 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638001820 Methyltransferase domain; Region: Methyltransf_31; pfam13847 863638001821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638001822 S-adenosylmethionine binding site [chemical binding]; other site 863638001823 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 863638001824 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638001825 dimerization interface [polypeptide binding]; other site 863638001826 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638001827 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 863638001828 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638001829 dimer interface [polypeptide binding]; other site 863638001830 putative CheW interface [polypeptide binding]; other site 863638001831 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 863638001832 HAMP domain; Region: HAMP; pfam00672 863638001833 dimerization interface [polypeptide binding]; other site 863638001834 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638001835 dimer interface [polypeptide binding]; other site 863638001836 putative CheW interface [polypeptide binding]; other site 863638001837 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 863638001838 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 863638001839 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 863638001840 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 863638001841 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 863638001842 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638001843 non-specific DNA binding site [nucleotide binding]; other site 863638001844 salt bridge; other site 863638001845 sequence-specific DNA binding site [nucleotide binding]; other site 863638001846 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 863638001847 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 863638001848 DNA binding residues [nucleotide binding] 863638001849 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638001850 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 863638001851 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638001852 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638001853 Haemolysin XhlA; Region: XhlA; pfam10779 863638001854 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 863638001855 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 863638001856 active site 863638001857 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 863638001858 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 863638001859 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 863638001860 Predicted membrane protein [Function unknown]; Region: COG2717 863638001861 Uncharacterized conserved protein [Function unknown]; Region: COG2013 863638001862 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 863638001863 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 863638001864 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 863638001865 putative DNA binding site [nucleotide binding]; other site 863638001866 putative Zn2+ binding site [ion binding]; other site 863638001867 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 863638001868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638001869 putative substrate translocation pore; other site 863638001870 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 863638001871 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 863638001872 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 863638001873 Dockerin type I repeat; Region: Dockerin_1; pfam00404 863638001874 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638001875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638001876 active site 863638001877 phosphorylation site [posttranslational modification] 863638001878 intermolecular recognition site; other site 863638001879 dimerization interface [polypeptide binding]; other site 863638001880 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638001881 DNA binding site [nucleotide binding] 863638001882 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 863638001883 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638001884 dimerization interface [polypeptide binding]; other site 863638001885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638001886 dimer interface [polypeptide binding]; other site 863638001887 phosphorylation site [posttranslational modification] 863638001888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638001889 ATP binding site [chemical binding]; other site 863638001890 Mg2+ binding site [ion binding]; other site 863638001891 G-X-G motif; other site 863638001892 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 863638001893 Methyltransferase domain; Region: Methyltransf_31; pfam13847 863638001894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638001895 S-adenosylmethionine binding site [chemical binding]; other site 863638001896 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 863638001897 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 863638001898 Ribosome-binding factor A; Region: RBFA; cl00542 863638001899 CAT RNA binding domain; Region: CAT_RBD; smart01061 863638001900 transcriptional antiterminator BglG; Provisional; Region: PRK09772 863638001901 PRD domain; Region: PRD; pfam00874 863638001902 PRD domain; Region: PRD; pfam00874 863638001903 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 863638001904 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 863638001905 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 863638001906 active site turn [active] 863638001907 phosphorylation site [posttranslational modification] 863638001908 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 863638001909 HPr interaction site; other site 863638001910 glycerol kinase (GK) interaction site [polypeptide binding]; other site 863638001911 active site 863638001912 phosphorylation site [posttranslational modification] 863638001913 Predicted transcriptional regulators [Transcription]; Region: COG1695 863638001914 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 863638001915 Predicted membrane protein [Function unknown]; Region: COG4709 863638001916 Uncharacterized conserved protein [Function unknown]; Region: COG3595 863638001917 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 863638001918 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 863638001919 Pectate lyase; Region: Pec_lyase_C; cl01593 863638001920 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 863638001921 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 863638001922 substrate binding site [chemical binding]; other site 863638001923 active site 863638001924 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 863638001925 putative sugar binding sites [chemical binding]; other site 863638001926 Q-X-W motif; other site 863638001927 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 863638001928 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 863638001929 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 863638001930 substrate binding pocket [chemical binding]; other site 863638001931 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 863638001932 B12 binding site [chemical binding]; other site 863638001933 cobalt ligand [ion binding]; other site 863638001934 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 863638001935 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 863638001936 AAA ATPase domain; Region: AAA_16; pfam13191 863638001937 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 863638001938 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 863638001939 metal ion-dependent adhesion site (MIDAS); other site 863638001940 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 863638001941 SpoVR like protein; Region: SpoVR; pfam04293 863638001942 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 863638001943 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 863638001944 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 863638001945 active site 863638001946 C-terminal domain interface [polypeptide binding]; other site 863638001947 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 863638001948 active site 863638001949 N-terminal domain interface [polypeptide binding]; other site 863638001950 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 863638001951 active site 863638001952 putative homodimer interface [polypeptide binding]; other site 863638001953 SAM binding site [chemical binding]; other site 863638001954 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 863638001955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638001956 active site 863638001957 phosphorylation site [posttranslational modification] 863638001958 intermolecular recognition site; other site 863638001959 dimerization interface [polypeptide binding]; other site 863638001960 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 863638001961 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 863638001962 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 863638001963 flavodoxin; Provisional; Region: PRK05568 863638001964 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 863638001965 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 863638001966 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 863638001967 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 863638001968 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 863638001969 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 863638001970 catalytic motif [active] 863638001971 Zn binding site [ion binding]; other site 863638001972 RibD C-terminal domain; Region: RibD_C; cl17279 863638001973 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 863638001974 Lumazine binding domain; Region: Lum_binding; pfam00677 863638001975 Lumazine binding domain; Region: Lum_binding; pfam00677 863638001976 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 863638001977 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 863638001978 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 863638001979 dimerization interface [polypeptide binding]; other site 863638001980 active site 863638001981 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 863638001982 homopentamer interface [polypeptide binding]; other site 863638001983 active site 863638001984 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 863638001985 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 863638001986 active site 863638001987 multimer interface [polypeptide binding]; other site 863638001988 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 863638001989 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 863638001990 predicted active site [active] 863638001991 catalytic triad [active] 863638001992 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 863638001993 Spore germination protein; Region: Spore_permease; pfam03845 863638001994 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 863638001995 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 863638001996 Predicted transcriptional regulators [Transcription]; Region: COG1725 863638001997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 863638001998 DNA-binding site [nucleotide binding]; DNA binding site 863638001999 Predicted membrane protein [General function prediction only]; Region: COG4194 863638002000 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 863638002001 FtsH Extracellular; Region: FtsH_ext; pfam06480 863638002002 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 863638002003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638002004 Walker A motif; other site 863638002005 ATP binding site [chemical binding]; other site 863638002006 Walker B motif; other site 863638002007 arginine finger; other site 863638002008 Peptidase family M41; Region: Peptidase_M41; pfam01434 863638002009 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 863638002010 Part of AAA domain; Region: AAA_19; pfam13245 863638002011 Family description; Region: UvrD_C_2; pfam13538 863638002012 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 863638002013 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 863638002014 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 863638002015 active site 863638002016 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 863638002017 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 863638002018 Cation efflux family; Region: Cation_efflux; cl00316 863638002019 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 863638002020 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 863638002021 active site 863638002022 metal binding site [ion binding]; metal-binding site 863638002023 diaminopimelate decarboxylase; Region: lysA; TIGR01048 863638002024 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 863638002025 active site 863638002026 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 863638002027 substrate binding site [chemical binding]; other site 863638002028 catalytic residues [active] 863638002029 dimer interface [polypeptide binding]; other site 863638002030 Putative glucoamylase; Region: Glycoamylase; pfam10091 863638002031 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 863638002032 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 863638002033 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 863638002034 Protein of unknown function, DUF608; Region: DUF608; pfam04685 863638002035 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 863638002036 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 863638002037 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 863638002038 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 863638002039 dinuclear metal binding motif [ion binding]; other site 863638002040 HEAT repeats; Region: HEAT_2; pfam13646 863638002041 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 863638002042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638002043 dimer interface [polypeptide binding]; other site 863638002044 conserved gate region; other site 863638002045 putative PBP binding loops; other site 863638002046 ABC-ATPase subunit interface; other site 863638002047 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 863638002048 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 863638002049 Walker A/P-loop; other site 863638002050 ATP binding site [chemical binding]; other site 863638002051 Q-loop/lid; other site 863638002052 ABC transporter signature motif; other site 863638002053 Walker B; other site 863638002054 D-loop; other site 863638002055 H-loop/switch region; other site 863638002056 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 863638002057 NMT1-like family; Region: NMT1_2; pfam13379 863638002058 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 863638002059 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 863638002060 polyphosphate kinase; Provisional; Region: PRK05443 863638002061 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 863638002062 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 863638002063 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 863638002064 putative domain interface [polypeptide binding]; other site 863638002065 putative active site [active] 863638002066 catalytic site [active] 863638002067 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 863638002068 putative domain interface [polypeptide binding]; other site 863638002069 putative active site [active] 863638002070 catalytic site [active] 863638002071 Predicted protease [Posttranslational modification, protein turnover, chaperones]; Region: COG4934 863638002072 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 863638002073 peptidase domain interface [polypeptide binding]; other site 863638002074 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 863638002075 active site 863638002076 catalytic triad [active] 863638002077 calcium binding site [ion binding]; other site 863638002078 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 863638002079 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 863638002080 active site 863638002081 HIGH motif; other site 863638002082 dimer interface [polypeptide binding]; other site 863638002083 KMSKS motif; other site 863638002084 Transcriptional regulators [Transcription]; Region: MarR; COG1846 863638002085 MarR family; Region: MarR_2; pfam12802 863638002086 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 863638002087 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 863638002088 sugar phosphate phosphatase; Provisional; Region: PRK10513 863638002089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638002090 active site 863638002091 motif I; other site 863638002092 motif II; other site 863638002093 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638002094 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 863638002095 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 863638002096 G1 box; other site 863638002097 putative GEF interaction site [polypeptide binding]; other site 863638002098 GTP/Mg2+ binding site [chemical binding]; other site 863638002099 Switch I region; other site 863638002100 G2 box; other site 863638002101 G3 box; other site 863638002102 Switch II region; other site 863638002103 G4 box; other site 863638002104 G5 box; other site 863638002105 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 863638002106 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 863638002107 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 863638002108 metal binding site [ion binding]; metal-binding site 863638002109 active site 863638002110 I-site; other site 863638002111 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 863638002112 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 863638002113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638002114 motif II; other site 863638002115 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 863638002116 active site 863638002117 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 863638002118 Predicted membrane protein [Function unknown]; Region: COG4720 863638002119 Probable zinc-binding domain; Region: zf-trcl; pfam13451 863638002120 GAF domain; Region: GAF_3; pfam13492 863638002121 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 863638002122 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 863638002123 metal binding site [ion binding]; metal-binding site 863638002124 active site 863638002125 I-site; other site 863638002126 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 863638002127 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 863638002128 active site 863638002129 HIGH motif; other site 863638002130 dimer interface [polypeptide binding]; other site 863638002131 KMSKS motif; other site 863638002132 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 863638002133 RNA binding surface [nucleotide binding]; other site 863638002134 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 863638002135 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 863638002136 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 863638002137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 863638002138 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 863638002139 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 863638002140 synthetase active site [active] 863638002141 NTP binding site [chemical binding]; other site 863638002142 metal binding site [ion binding]; metal-binding site 863638002143 Spore germination protein; Region: Spore_permease; cl17796 863638002144 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 863638002145 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 863638002146 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 863638002147 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 863638002148 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 863638002149 HIGH motif; other site 863638002150 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 863638002151 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 863638002152 active site 863638002153 KMSKS motif; other site 863638002154 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 863638002155 tRNA binding surface [nucleotide binding]; other site 863638002156 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 863638002157 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 863638002158 HSP70 interaction site [polypeptide binding]; other site 863638002159 TPR repeat; Region: TPR_11; pfam13414 863638002160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 863638002161 binding surface 863638002162 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 863638002163 putative active site [active] 863638002164 putative metal binding residues [ion binding]; other site 863638002165 putative triphosphate binding site [ion binding]; other site 863638002166 signature motif; other site 863638002167 dimer interface [polypeptide binding]; other site 863638002168 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 863638002169 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 863638002170 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638002171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638002172 active site 863638002173 phosphorylation site [posttranslational modification] 863638002174 intermolecular recognition site; other site 863638002175 dimerization interface [polypeptide binding]; other site 863638002176 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638002177 DNA binding site [nucleotide binding] 863638002178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638002179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638002180 ATP binding site [chemical binding]; other site 863638002181 Mg2+ binding site [ion binding]; other site 863638002182 G-X-G motif; other site 863638002183 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 863638002184 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 863638002185 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638002186 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 863638002187 FeS/SAM binding site; other site 863638002188 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 863638002189 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 863638002190 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 863638002191 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 863638002192 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 863638002193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638002194 Walker A/P-loop; other site 863638002195 ATP binding site [chemical binding]; other site 863638002196 Q-loop/lid; other site 863638002197 ABC transporter signature motif; other site 863638002198 Walker B; other site 863638002199 D-loop; other site 863638002200 H-loop/switch region; other site 863638002201 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 863638002202 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 863638002203 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 863638002204 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 863638002205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638002206 dimer interface [polypeptide binding]; other site 863638002207 conserved gate region; other site 863638002208 ABC-ATPase subunit interface; other site 863638002209 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 863638002210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638002211 dimer interface [polypeptide binding]; other site 863638002212 conserved gate region; other site 863638002213 putative PBP binding loops; other site 863638002214 ABC-ATPase subunit interface; other site 863638002215 HlyD family secretion protein; Region: HlyD_2; pfam12700 863638002216 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 863638002217 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 863638002218 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 863638002219 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 863638002220 Predicted membrane protein [Function unknown]; Region: COG2323 863638002221 Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ThrS; COG0441 863638002222 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 863638002223 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 863638002224 active site 863638002225 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 863638002226 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 863638002227 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 863638002228 putative L-serine binding site [chemical binding]; other site 863638002229 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 863638002230 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 863638002231 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 863638002232 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 863638002233 Uncharacterized conserved protein [Function unknown]; Region: COG0398 863638002234 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 863638002235 FOG: CBS domain [General function prediction only]; Region: COG0517 863638002236 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 863638002237 putative lipid kinase; Reviewed; Region: PRK13059 863638002238 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 863638002239 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 863638002240 Nitrogen regulatory protein P-II; Region: P-II; smart00938 863638002241 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 863638002242 PRC-barrel domain; Region: PRC; pfam05239 863638002243 MgtE intracellular N domain; Region: MgtE_N; smart00924 863638002244 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 863638002245 FOG: CBS domain [General function prediction only]; Region: COG0517 863638002246 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 863638002247 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 863638002248 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 863638002249 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 863638002250 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 863638002251 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 863638002252 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 863638002253 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 863638002254 trimer interface [polypeptide binding]; other site 863638002255 active site 863638002256 substrate binding site [chemical binding]; other site 863638002257 CoA binding site [chemical binding]; other site 863638002258 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 863638002259 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 863638002260 putative acyl-acceptor binding pocket; other site 863638002261 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 863638002262 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 863638002263 minor groove reading motif; other site 863638002264 helix-hairpin-helix signature motif; other site 863638002265 substrate binding pocket [chemical binding]; other site 863638002266 active site 863638002267 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 863638002268 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 863638002269 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 863638002270 putative oligomer interface [polypeptide binding]; other site 863638002271 putative active site [active] 863638002272 metal binding site [ion binding]; metal-binding site 863638002273 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 863638002274 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 863638002275 VanW like protein; Region: VanW; pfam04294 863638002276 Glucuronate isomerase; Region: UxaC; pfam02614 863638002277 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 863638002278 Transcriptional regulators [Transcription]; Region: PurR; COG1609 863638002279 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 863638002280 DNA binding site [nucleotide binding] 863638002281 domain linker motif; other site 863638002282 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 863638002283 dimerization interface [polypeptide binding]; other site 863638002284 ligand binding site [chemical binding]; other site 863638002285 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 863638002286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638002287 putative substrate translocation pore; other site 863638002288 altronate oxidoreductase; Provisional; Region: PRK03643 863638002289 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 863638002290 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 863638002291 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 863638002292 galactarate dehydratase; Region: galactar-dH20; TIGR03248 863638002293 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 863638002294 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 863638002295 active site 863638002296 catalytic residues [active] 863638002297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638002298 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 863638002299 active site 863638002300 motif I; other site 863638002301 motif II; other site 863638002302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638002303 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 863638002304 spore photoproduct lyase; Region: photo_TT_lyase; TIGR04070 863638002305 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 863638002306 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 863638002307 EDD domain protein, DegV family; Region: DegV; TIGR00762 863638002308 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 863638002309 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 863638002310 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 863638002311 ligand binding site [chemical binding]; other site 863638002312 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 863638002313 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 863638002314 Walker A/P-loop; other site 863638002315 ATP binding site [chemical binding]; other site 863638002316 Q-loop/lid; other site 863638002317 ABC transporter signature motif; other site 863638002318 Walker B; other site 863638002319 D-loop; other site 863638002320 H-loop/switch region; other site 863638002321 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 863638002322 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 863638002323 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 863638002324 TM-ABC transporter signature motif; other site 863638002325 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 863638002326 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 863638002327 TM-ABC transporter signature motif; other site 863638002328 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 863638002329 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 863638002330 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 863638002331 putative sugar binding sites [chemical binding]; other site 863638002332 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 863638002333 Q-X-W motif; other site 863638002334 Ricin-type beta-trefoil; Region: RICIN; smart00458 863638002335 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 863638002336 putative sugar binding sites [chemical binding]; other site 863638002337 Q-X-W motif; other site 863638002338 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 863638002339 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 863638002340 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 863638002341 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 863638002342 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 863638002343 Predicted transcriptional regulator [Transcription]; Region: COG3388 863638002344 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 863638002345 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 863638002346 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 863638002347 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 863638002348 Phosphoglycerate kinase; Region: PGK; pfam00162 863638002349 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 863638002350 substrate binding site [chemical binding]; other site 863638002351 hinge regions; other site 863638002352 ADP binding site [chemical binding]; other site 863638002353 catalytic site [active] 863638002354 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 863638002355 triosephosphate isomerase; Provisional; Region: PRK14567 863638002356 substrate binding site [chemical binding]; other site 863638002357 dimer interface [polypeptide binding]; other site 863638002358 catalytic triad [active] 863638002359 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 863638002360 phosphoglyceromutase; Provisional; Region: PRK05434 863638002361 enolase; Provisional; Region: eno; PRK00077 863638002362 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 863638002363 dimer interface [polypeptide binding]; other site 863638002364 metal binding site [ion binding]; metal-binding site 863638002365 substrate binding pocket [chemical binding]; other site 863638002366 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 863638002367 ribonuclease R; Region: RNase_R; TIGR02063 863638002368 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 863638002369 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 863638002370 RNB domain; Region: RNB; pfam00773 863638002371 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 863638002372 RNA binding site [nucleotide binding]; other site 863638002373 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 863638002374 SmpB-tmRNA interface; other site 863638002375 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 863638002376 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 863638002377 dimer interface [polypeptide binding]; other site 863638002378 FMN binding site [chemical binding]; other site 863638002379 NADPH bind site [chemical binding]; other site 863638002380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 863638002381 active site 863638002382 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 863638002383 Epoxide hydrolase N terminus; Region: EHN; pfam06441 863638002384 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 863638002385 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 863638002386 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 863638002387 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 863638002388 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638002389 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638002390 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 863638002391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638002392 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 863638002393 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 863638002394 putative transport protein YifK; Provisional; Region: PRK10746 863638002395 Methyltransferase domain; Region: Methyltransf_31; pfam13847 863638002396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638002397 S-adenosylmethionine binding site [chemical binding]; other site 863638002398 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 863638002399 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 863638002400 Domain of unknown function DUF20; Region: UPF0118; pfam01594 863638002401 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 863638002402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 863638002403 NAD(P) binding site [chemical binding]; other site 863638002404 active site 863638002405 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 863638002406 GAF domain; Region: GAF_3; pfam13492 863638002407 Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960 863638002408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4878 863638002409 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 863638002410 NodB motif; other site 863638002411 putative active site [active] 863638002412 putative catalytic site [active] 863638002413 putative Zn binding site [ion binding]; other site 863638002414 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 863638002415 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638002416 Predicted membrane protein [Function unknown]; Region: COG4267 863638002417 Uncharacterized conserved protein [Function unknown]; Region: COG3868 863638002418 glutamate dehydrogenase; Provisional; Region: PRK09414 863638002419 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 863638002420 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 863638002421 NAD(P) binding site [chemical binding]; other site 863638002422 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 863638002423 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 863638002424 active site 863638002425 catalytic site [active] 863638002426 substrate binding site [chemical binding]; other site 863638002427 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 863638002428 Dimer interface [polypeptide binding]; other site 863638002429 BRCT sequence motif; other site 863638002430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 863638002431 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638002432 dimer interface [polypeptide binding]; other site 863638002433 putative CheW interface [polypeptide binding]; other site 863638002434 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 863638002435 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 863638002436 active site 863638002437 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 863638002438 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 863638002439 beta-galactosidase; Region: BGL; TIGR03356 863638002440 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 863638002441 Transcriptional regulator [Transcription]; Region: LysR; COG0583 863638002442 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 863638002443 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 863638002444 dimerization interface [polypeptide binding]; other site 863638002445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 863638002446 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 863638002447 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 863638002448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 863638002449 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 863638002450 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 863638002451 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 863638002452 FMN binding site [chemical binding]; other site 863638002453 dimer interface [polypeptide binding]; other site 863638002454 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 863638002455 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638002456 Zn2+ binding site [ion binding]; other site 863638002457 Mg2+ binding site [ion binding]; other site 863638002458 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 863638002459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638002460 putative substrate translocation pore; other site 863638002461 RNA ligase; Region: RNA_ligase; pfam09414 863638002462 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638002463 Zn2+ binding site [ion binding]; other site 863638002464 Mg2+ binding site [ion binding]; other site 863638002465 AAA domain; Region: AAA_33; pfam13671 863638002466 SseB protein; Region: SseB; cl06279 863638002467 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 863638002468 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 863638002469 Bystin; Region: Bystin; pfam05291 863638002470 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 863638002471 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 863638002472 Hemerythrin-like domain; Region: Hr-like; cd12108 863638002473 Fe binding site [ion binding]; other site 863638002474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638002475 Major Facilitator Superfamily; Region: MFS_1; pfam07690 863638002476 putative substrate translocation pore; other site 863638002477 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 863638002478 MarR family; Region: MarR; pfam01047 863638002479 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 863638002480 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 863638002481 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 863638002482 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 863638002483 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 863638002484 active site 863638002485 catalytic tetrad [active] 863638002486 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 863638002487 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 863638002488 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 863638002489 DNA binding residues [nucleotide binding] 863638002490 putative dimer interface [polypeptide binding]; other site 863638002491 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 863638002492 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 863638002493 active site 863638002494 catalytic tetrad [active] 863638002495 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 863638002496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 863638002497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 863638002498 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 863638002499 dimerization interface [polypeptide binding]; other site 863638002500 Uncharacterized conserved protein [Function unknown]; Region: COG3875 863638002501 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 863638002502 amphipathic channel; other site 863638002503 Asn-Pro-Ala signature motifs; other site 863638002504 cobalt transport protein CbiM; Provisional; Region: PRK07331 863638002505 cobalt transport protein CbiM; Provisional; Region: PRK11909 863638002506 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 863638002507 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 863638002508 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 863638002509 Walker A/P-loop; other site 863638002510 ATP binding site [chemical binding]; other site 863638002511 Q-loop/lid; other site 863638002512 ABC transporter signature motif; other site 863638002513 Walker B; other site 863638002514 D-loop; other site 863638002515 H-loop/switch region; other site 863638002516 hypothetical protein; Provisional; Region: PRK04194 863638002517 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 863638002518 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 863638002519 Ligand Binding Site [chemical binding]; other site 863638002520 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 863638002521 AIR carboxylase; Region: AIRC; smart01001 863638002522 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 863638002523 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 863638002524 trimer interface [polypeptide binding]; other site 863638002525 active site 863638002526 substrate binding site [chemical binding]; other site 863638002527 CoA binding site [chemical binding]; other site 863638002528 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 863638002529 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 863638002530 ATP binding site [chemical binding]; other site 863638002531 putative Mg++ binding site [ion binding]; other site 863638002532 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 863638002533 nucleotide binding region [chemical binding]; other site 863638002534 ATP-binding site [chemical binding]; other site 863638002535 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 863638002536 Isochorismatase family; Region: Isochorismatase; pfam00857 863638002537 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 863638002538 catalytic triad [active] 863638002539 conserved cis-peptide bond; other site 863638002540 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 863638002541 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 863638002542 active site 863638002543 HIGH motif; other site 863638002544 dimer interface [polypeptide binding]; other site 863638002545 KMSKS motif; other site 863638002546 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 863638002547 RNA binding surface [nucleotide binding]; other site 863638002548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4296 863638002549 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 863638002550 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 863638002551 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 863638002552 DEAD-like helicases superfamily; Region: DEXDc; smart00487 863638002553 ATP binding site [chemical binding]; other site 863638002554 Mg++ binding site [ion binding]; other site 863638002555 motif III; other site 863638002556 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 863638002557 nucleotide binding region [chemical binding]; other site 863638002558 ATP-binding site [chemical binding]; other site 863638002559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 863638002560 conserved domain; Region: TIGR02271 863638002561 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 863638002562 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 863638002563 ABC-ATPase subunit interface; other site 863638002564 dimer interface [polypeptide binding]; other site 863638002565 putative PBP binding regions; other site 863638002566 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 863638002567 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 863638002568 ABC-ATPase subunit interface; other site 863638002569 dimer interface [polypeptide binding]; other site 863638002570 putative PBP binding regions; other site 863638002571 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 863638002572 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 863638002573 putative ligand binding residues [chemical binding]; other site 863638002574 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 863638002575 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 863638002576 Walker A/P-loop; other site 863638002577 ATP binding site [chemical binding]; other site 863638002578 Q-loop/lid; other site 863638002579 ABC transporter signature motif; other site 863638002580 Walker B; other site 863638002581 D-loop; other site 863638002582 H-loop/switch region; other site 863638002583 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 863638002584 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 863638002585 homodimer interface [polypeptide binding]; other site 863638002586 substrate-cofactor binding pocket; other site 863638002587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638002588 catalytic residue [active] 863638002589 Plant protein of unknown function (DUF946); Region: DUF946; pfam06101 863638002590 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 863638002591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 863638002592 NAD(P) binding site [chemical binding]; other site 863638002593 active site 863638002594 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 863638002595 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 863638002596 active site 863638002597 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 863638002598 Putative integral membrane protein DUF46; Region: DUF46; cl17511 863638002599 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 863638002600 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 863638002601 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 863638002602 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 863638002603 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 863638002604 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 863638002605 prenyltransferase; Provisional; Region: ubiA; PRK13592 863638002606 UbiA prenyltransferase family; Region: UbiA; pfam01040 863638002607 phosphoenolpyruvate synthase; Validated; Region: PRK06241 863638002608 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 863638002609 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 863638002610 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 863638002611 Pectate lyase; Region: Pec_lyase_C; cl01593 863638002612 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 863638002613 Cache domain; Region: Cache_1; pfam02743 863638002614 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 863638002615 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638002616 dimerization interface [polypeptide binding]; other site 863638002617 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638002618 dimer interface [polypeptide binding]; other site 863638002619 putative CheW interface [polypeptide binding]; other site 863638002620 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 863638002621 DNA-binding site [nucleotide binding]; DNA binding site 863638002622 RNA-binding motif; other site 863638002623 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 863638002624 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 863638002625 dimerization interface [polypeptide binding]; other site 863638002626 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 863638002627 ATP binding site [chemical binding]; other site 863638002628 Acylphosphatase; Region: Acylphosphatase; pfam00708 863638002629 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 863638002630 HypF finger; Region: zf-HYPF; pfam07503 863638002631 HypF finger; Region: zf-HYPF; pfam07503 863638002632 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 863638002633 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 863638002634 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 863638002635 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 863638002636 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 863638002637 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 863638002638 dimer interface [polypeptide binding]; other site 863638002639 active site 863638002640 CoA binding pocket [chemical binding]; other site 863638002641 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638002642 dimer interface [polypeptide binding]; other site 863638002643 putative CheW interface [polypeptide binding]; other site 863638002644 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 863638002645 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 863638002646 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 863638002647 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 863638002648 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 863638002649 metal binding site [ion binding]; metal-binding site 863638002650 active site 863638002651 I-site; other site 863638002652 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 863638002653 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 863638002654 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 863638002655 active site 863638002656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 863638002657 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638002658 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638002659 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638002660 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 863638002661 Walker A/P-loop; other site 863638002662 ATP binding site [chemical binding]; other site 863638002663 Q-loop/lid; other site 863638002664 ABC transporter signature motif; other site 863638002665 Walker B; other site 863638002666 D-loop; other site 863638002667 H-loop/switch region; other site 863638002668 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 863638002669 FtsX-like permease family; Region: FtsX; pfam02687 863638002670 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 863638002671 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 863638002672 FtsX-like permease family; Region: FtsX; pfam02687 863638002673 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 863638002674 catalytic residues [active] 863638002675 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 863638002676 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 863638002677 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 863638002678 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 863638002679 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 863638002680 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 863638002681 intersubunit interface [polypeptide binding]; other site 863638002682 active site 863638002683 zinc binding site [ion binding]; other site 863638002684 Na+ binding site [ion binding]; other site 863638002685 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 863638002686 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638002687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638002688 active site 863638002689 phosphorylation site [posttranslational modification] 863638002690 intermolecular recognition site; other site 863638002691 dimerization interface [polypeptide binding]; other site 863638002692 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638002693 DNA binding site [nucleotide binding] 863638002694 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638002695 dimerization interface [polypeptide binding]; other site 863638002696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638002697 dimer interface [polypeptide binding]; other site 863638002698 phosphorylation site [posttranslational modification] 863638002699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638002700 ATP binding site [chemical binding]; other site 863638002701 Mg2+ binding site [ion binding]; other site 863638002702 G-X-G motif; other site 863638002703 Predicted transcriptional regulators [Transcription]; Region: COG1695 863638002704 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 863638002705 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 863638002706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638002707 Walker A/P-loop; other site 863638002708 ATP binding site [chemical binding]; other site 863638002709 Q-loop/lid; other site 863638002710 ABC transporter signature motif; other site 863638002711 Walker B; other site 863638002712 D-loop; other site 863638002713 H-loop/switch region; other site 863638002714 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 863638002715 ABC-2 type transporter; Region: ABC2_membrane; cl17235 863638002716 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 863638002717 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 863638002718 Domain of unknown function (DUF386); Region: DUF386; pfam04074 863638002719 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 863638002720 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 863638002721 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 863638002722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638002723 dimer interface [polypeptide binding]; other site 863638002724 putative PBP binding loops; other site 863638002725 ABC-ATPase subunit interface; other site 863638002726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638002727 dimer interface [polypeptide binding]; other site 863638002728 conserved gate region; other site 863638002729 putative PBP binding loops; other site 863638002730 ABC-ATPase subunit interface; other site 863638002731 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 863638002732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638002733 Walker A/P-loop; other site 863638002734 ATP binding site [chemical binding]; other site 863638002735 Q-loop/lid; other site 863638002736 ABC transporter signature motif; other site 863638002737 Walker B; other site 863638002738 D-loop; other site 863638002739 H-loop/switch region; other site 863638002740 TOBE domain; Region: TOBE_2; pfam08402 863638002741 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 863638002742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638002743 non-specific DNA binding site [nucleotide binding]; other site 863638002744 salt bridge; other site 863638002745 sequence-specific DNA binding site [nucleotide binding]; other site 863638002746 Cupin domain; Region: Cupin_2; pfam07883 863638002747 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 863638002748 active site 863638002749 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 863638002750 RNAase interaction site [polypeptide binding]; other site 863638002751 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 863638002752 Ferritin-like domain; Region: Ferritin; pfam00210 863638002753 ferroxidase diiron center [ion binding]; other site 863638002754 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 863638002755 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 863638002756 Uncharacterized conserved protein [Function unknown]; Region: COG1284 863638002757 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 863638002758 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 863638002759 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 863638002760 Predicted transcriptional regulators [Transcription]; Region: COG1733 863638002761 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 863638002762 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 863638002763 dimer interface [polypeptide binding]; other site 863638002764 FMN binding site [chemical binding]; other site 863638002765 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 863638002766 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 863638002767 putative active site [active] 863638002768 metal binding site [ion binding]; metal-binding site 863638002769 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 863638002770 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 863638002771 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638002772 Zn2+ binding site [ion binding]; other site 863638002773 Mg2+ binding site [ion binding]; other site 863638002774 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 863638002775 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 863638002776 G1 box; other site 863638002777 putative GEF interaction site [polypeptide binding]; other site 863638002778 GTP/Mg2+ binding site [chemical binding]; other site 863638002779 Switch I region; other site 863638002780 G2 box; other site 863638002781 G3 box; other site 863638002782 Switch II region; other site 863638002783 G4 box; other site 863638002784 G5 box; other site 863638002785 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 863638002786 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 863638002787 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 863638002788 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 863638002789 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 863638002790 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638002791 motif II; other site 863638002792 Transcriptional regulators [Transcription]; Region: PurR; COG1609 863638002793 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 863638002794 DNA binding site [nucleotide binding] 863638002795 domain linker motif; other site 863638002796 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 863638002797 putative dimerization interface [polypeptide binding]; other site 863638002798 putative ligand binding site [chemical binding]; other site 863638002799 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 863638002800 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 863638002801 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 863638002802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638002803 Coenzyme A binding pocket [chemical binding]; other site 863638002804 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 863638002805 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 863638002806 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638002807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638002808 active site 863638002809 phosphorylation site [posttranslational modification] 863638002810 intermolecular recognition site; other site 863638002811 dimerization interface [polypeptide binding]; other site 863638002812 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638002813 DNA binding site [nucleotide binding] 863638002814 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 863638002815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638002816 Walker A/P-loop; other site 863638002817 ATP binding site [chemical binding]; other site 863638002818 Q-loop/lid; other site 863638002819 ABC transporter signature motif; other site 863638002820 Walker B; other site 863638002821 D-loop; other site 863638002822 H-loop/switch region; other site 863638002823 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 863638002824 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 863638002825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638002826 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638002827 dimer interface [polypeptide binding]; other site 863638002828 phosphorylation site [posttranslational modification] 863638002829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638002830 ATP binding site [chemical binding]; other site 863638002831 Mg2+ binding site [ion binding]; other site 863638002832 G-X-G motif; other site 863638002833 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 863638002834 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 863638002835 Histidine kinase; Region: HisKA_3; pfam07730 863638002836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638002837 ATP binding site [chemical binding]; other site 863638002838 Mg2+ binding site [ion binding]; other site 863638002839 G-X-G motif; other site 863638002840 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 863638002841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638002842 active site 863638002843 phosphorylation site [posttranslational modification] 863638002844 intermolecular recognition site; other site 863638002845 dimerization interface [polypeptide binding]; other site 863638002846 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 863638002847 DNA binding residues [nucleotide binding] 863638002848 dimerization interface [polypeptide binding]; other site 863638002849 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 863638002850 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638002851 Walker A/P-loop; other site 863638002852 ATP binding site [chemical binding]; other site 863638002853 Q-loop/lid; other site 863638002854 ABC transporter signature motif; other site 863638002855 Walker B; other site 863638002856 D-loop; other site 863638002857 H-loop/switch region; other site 863638002858 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 863638002859 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 863638002860 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 863638002861 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 863638002862 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 863638002863 xanthine permease; Region: pbuX; TIGR03173 863638002864 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 863638002865 active site 863638002866 EamA-like transporter family; Region: EamA; pfam00892 863638002867 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 863638002868 EamA-like transporter family; Region: EamA; pfam00892 863638002869 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 863638002870 MarR family; Region: MarR; pfam01047 863638002871 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 863638002872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638002873 S-adenosylmethionine binding site [chemical binding]; other site 863638002874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638002875 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 863638002876 dimer interface [polypeptide binding]; other site 863638002877 conserved gate region; other site 863638002878 putative PBP binding loops; other site 863638002879 ABC-ATPase subunit interface; other site 863638002880 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 863638002881 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 863638002882 Walker A/P-loop; other site 863638002883 ATP binding site [chemical binding]; other site 863638002884 Q-loop/lid; other site 863638002885 ABC transporter signature motif; other site 863638002886 Walker B; other site 863638002887 D-loop; other site 863638002888 H-loop/switch region; other site 863638002889 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 863638002890 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 863638002891 substrate binding pocket [chemical binding]; other site 863638002892 membrane-bound complex binding site; other site 863638002893 hinge residues; other site 863638002894 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 863638002895 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 863638002896 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 863638002897 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 863638002898 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 863638002899 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 863638002900 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 863638002901 ligand binding site [chemical binding]; other site 863638002902 flexible hinge region; other site 863638002903 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 863638002904 Ferredoxin [Energy production and conversion]; Region: COG1146 863638002905 4Fe-4S binding domain; Region: Fer4; cl02805 863638002906 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 863638002907 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 863638002908 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 863638002909 active site 863638002910 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 863638002911 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 863638002912 Sulfatase; Region: Sulfatase; pfam00884 863638002913 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 863638002914 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 863638002915 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 863638002916 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 863638002917 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 863638002918 prephenate dehydrogenase; Validated; Region: PRK08507 863638002919 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 863638002920 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 863638002921 active site 863638002922 dimer interface [polypeptide binding]; other site 863638002923 metal binding site [ion binding]; metal-binding site 863638002924 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 863638002925 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 863638002926 hinge; other site 863638002927 active site 863638002928 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 863638002929 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 863638002930 Tetramer interface [polypeptide binding]; other site 863638002931 active site 863638002932 FMN-binding site [chemical binding]; other site 863638002933 monofunctional chorismate mutase, gram positive-type, clade 2; Region: CM_mono_grmpos; TIGR01805 863638002934 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 863638002935 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 863638002936 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 863638002937 shikimate binding site; other site 863638002938 NAD(P) binding site [chemical binding]; other site 863638002939 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 863638002940 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 863638002941 ADP binding site [chemical binding]; other site 863638002942 magnesium binding site [ion binding]; other site 863638002943 putative shikimate binding site; other site 863638002944 Dehydroquinase class II; Region: DHquinase_II; pfam01220 863638002945 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 863638002946 trimer interface [polypeptide binding]; other site 863638002947 active site 863638002948 dimer interface [polypeptide binding]; other site 863638002949 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 863638002950 UGMP family protein; Validated; Region: PRK09604 863638002951 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 863638002952 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 863638002953 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 863638002954 putative active site [active] 863638002955 heme pocket [chemical binding]; other site 863638002956 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638002957 dimer interface [polypeptide binding]; other site 863638002958 phosphorylation site [posttranslational modification] 863638002959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638002960 ATP binding site [chemical binding]; other site 863638002961 Mg2+ binding site [ion binding]; other site 863638002962 G-X-G motif; other site 863638002963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638002964 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 863638002965 Walker A motif; other site 863638002966 ATP binding site [chemical binding]; other site 863638002967 Walker B motif; other site 863638002968 arginine finger; other site 863638002969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638002970 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 863638002971 Walker A motif; other site 863638002972 ATP binding site [chemical binding]; other site 863638002973 Walker B motif; other site 863638002974 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 863638002975 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 863638002976 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 863638002977 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 863638002978 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 863638002979 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 863638002980 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 863638002981 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 863638002982 putative ATP binding site [chemical binding]; other site 863638002983 putative substrate interface [chemical binding]; other site 863638002984 Cache domain; Region: Cache_1; pfam02743 863638002985 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 863638002986 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638002987 dimerization interface [polypeptide binding]; other site 863638002988 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638002989 dimer interface [polypeptide binding]; other site 863638002990 putative CheW interface [polypeptide binding]; other site 863638002991 Cellulose binding domain; Region: CBM_3; pfam00942 863638002992 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 863638002993 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 863638002994 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 863638002995 dockerin binding interface; other site 863638002996 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 863638002997 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 863638002998 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 863638002999 dockerin binding interface; other site 863638003000 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 863638003001 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 863638003002 dockerin binding interface; other site 863638003003 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 863638003004 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 863638003005 dockerin binding interface; other site 863638003006 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 863638003007 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 863638003008 dockerin binding interface; other site 863638003009 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 863638003010 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 863638003011 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 863638003012 Dockerin type I repeat; Region: Dockerin_1; pfam00404 863638003013 endoglucanase; Region: PLN02420 863638003014 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 863638003015 Cellulose binding domain; Region: CBM_3; pfam00942 863638003016 Dockerin type I repeat; Region: Dockerin_1; pfam00404 863638003017 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 863638003018 dockerin binding interface; other site 863638003019 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 863638003020 endoglucanase; Region: PLN02420 863638003021 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 863638003022 Cellulose binding domain; Region: CBM_3; smart01067 863638003023 endoglucanase; Region: PLN02420 863638003024 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 863638003025 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 863638003026 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 863638003027 Dockerin type I repeat; Region: Dockerin_1; pfam00404 863638003028 VPS10 domain; Region: VPS10; smart00602 863638003029 Dockerin type I repeat; Region: Dockerin_1; pfam00404 863638003030 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 863638003031 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 863638003032 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 863638003033 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 863638003034 metal binding site [ion binding]; metal-binding site 863638003035 dimer interface [polypeptide binding]; other site 863638003036 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 863638003037 Tropomyosin like; Region: Tropomyosin_1; pfam12718 863638003038 TPR repeat; Region: TPR_11; pfam13414 863638003039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638003040 binding surface 863638003041 TPR motif; other site 863638003042 TPR repeat; Region: TPR_11; pfam13414 863638003043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638003044 binding surface 863638003045 TPR motif; other site 863638003046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638003047 binding surface 863638003048 TPR motif; other site 863638003049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638003050 binding surface 863638003051 TPR motif; other site 863638003052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 863638003053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638003054 S-adenosylmethionine binding site [chemical binding]; other site 863638003055 cystathionine beta-lyase; Provisional; Region: PRK07671 863638003056 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 863638003057 homodimer interface [polypeptide binding]; other site 863638003058 substrate-cofactor binding pocket; other site 863638003059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638003060 catalytic residue [active] 863638003061 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 863638003062 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 863638003063 dimer interface [polypeptide binding]; other site 863638003064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638003065 catalytic residue [active] 863638003066 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 863638003067 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 863638003068 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 863638003069 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 863638003070 phosphodiesterase; Provisional; Region: PRK12704 863638003071 ATP phosphoribosyltransferase involved in histidine biosynthesis [Amino acid transport and metabolism]; Region: HisZ; COG3705 863638003072 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 863638003073 dimer interface [polypeptide binding]; other site 863638003074 motif 1; other site 863638003075 active site 863638003076 motif 2; other site 863638003077 motif 3; other site 863638003078 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 863638003079 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 863638003080 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 863638003081 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 863638003082 NAD binding site [chemical binding]; other site 863638003083 dimerization interface [polypeptide binding]; other site 863638003084 product binding site; other site 863638003085 substrate binding site [chemical binding]; other site 863638003086 zinc binding site [ion binding]; other site 863638003087 catalytic residues [active] 863638003088 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 863638003089 putative active site pocket [active] 863638003090 4-fold oligomerization interface [polypeptide binding]; other site 863638003091 metal binding residues [ion binding]; metal-binding site 863638003092 3-fold/trimer interface [polypeptide binding]; other site 863638003093 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 863638003094 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 863638003095 putative active site [active] 863638003096 oxyanion strand; other site 863638003097 catalytic triad [active] 863638003098 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 863638003099 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 863638003100 catalytic residues [active] 863638003101 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 863638003102 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 863638003103 substrate binding site [chemical binding]; other site 863638003104 glutamase interaction surface [polypeptide binding]; other site 863638003105 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 863638003106 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 863638003107 metal binding site [ion binding]; metal-binding site 863638003108 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 863638003109 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 863638003110 TPP-binding site [chemical binding]; other site 863638003111 dimer interface [polypeptide binding]; other site 863638003112 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 863638003113 PYR/PP interface [polypeptide binding]; other site 863638003114 dimer interface [polypeptide binding]; other site 863638003115 TPP binding site [chemical binding]; other site 863638003116 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 863638003117 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 863638003118 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 863638003119 dimer interface [polypeptide binding]; other site 863638003120 ssDNA binding site [nucleotide binding]; other site 863638003121 tetramer (dimer of dimers) interface [polypeptide binding]; other site 863638003122 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 863638003123 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 863638003124 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 863638003125 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 863638003126 EDD domain protein, DegV family; Region: DegV; TIGR00762 863638003127 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 863638003128 Predicted transcriptional regulators [Transcription]; Region: COG1695 863638003129 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 863638003130 Predicted membrane protein [Function unknown]; Region: COG1971 863638003131 Domain of unknown function DUF; Region: DUF204; pfam02659 863638003132 Domain of unknown function DUF; Region: DUF204; pfam02659 863638003133 ferric uptake regulator; Provisional; Region: fur; PRK09462 863638003134 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 863638003135 metal binding site 2 [ion binding]; metal-binding site 863638003136 putative DNA binding helix; other site 863638003137 metal binding site 1 [ion binding]; metal-binding site 863638003138 dimer interface [polypeptide binding]; other site 863638003139 structural Zn2+ binding site [ion binding]; other site 863638003140 Rhomboid family; Region: Rhomboid; pfam01694 863638003141 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 863638003142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638003143 Walker A motif; other site 863638003144 ATP binding site [chemical binding]; other site 863638003145 Walker B motif; other site 863638003146 arginine finger; other site 863638003147 Peptidase family M41; Region: Peptidase_M41; pfam01434 863638003148 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 863638003149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638003150 non-specific DNA binding site [nucleotide binding]; other site 863638003151 salt bridge; other site 863638003152 sequence-specific DNA binding site [nucleotide binding]; other site 863638003153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 863638003154 binding surface 863638003155 TPR motif; other site 863638003156 Tetratricopeptide repeat; Region: TPR_12; pfam13424 863638003157 Tetratricopeptide repeat; Region: TPR_12; pfam13424 863638003158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 863638003159 binding surface 863638003160 TPR motif; other site 863638003161 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 863638003162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638003163 non-specific DNA binding site [nucleotide binding]; other site 863638003164 salt bridge; other site 863638003165 sequence-specific DNA binding site [nucleotide binding]; other site 863638003166 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 863638003167 Clp amino terminal domain; Region: Clp_N; pfam02861 863638003168 Clp amino terminal domain; Region: Clp_N; pfam02861 863638003169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638003170 Walker A motif; other site 863638003171 ATP binding site [chemical binding]; other site 863638003172 Walker B motif; other site 863638003173 arginine finger; other site 863638003174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638003175 Walker A motif; other site 863638003176 ATP binding site [chemical binding]; other site 863638003177 Walker B motif; other site 863638003178 arginine finger; other site 863638003179 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 863638003180 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 863638003181 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 863638003182 NodB motif; other site 863638003183 active site 863638003184 catalytic site [active] 863638003185 Zn binding site [ion binding]; other site 863638003186 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 863638003187 catalytic triad [active] 863638003188 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 863638003189 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 863638003190 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 863638003191 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 863638003192 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 863638003193 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 863638003194 putative acyl-acceptor binding pocket; other site 863638003195 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 863638003196 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 863638003197 active site 863638003198 catalytic residues [active] 863638003199 metal binding site [ion binding]; metal-binding site 863638003200 aconitate hydratase; Validated; Region: PRK07229 863638003201 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 863638003202 substrate binding site [chemical binding]; other site 863638003203 ligand binding site [chemical binding]; other site 863638003204 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 863638003205 substrate binding site [chemical binding]; other site 863638003206 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 863638003207 isocitrate dehydrogenase; Validated; Region: PRK06451 863638003208 argininosuccinate synthase; Provisional; Region: PRK13820 863638003209 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 863638003210 ANP binding site [chemical binding]; other site 863638003211 Substrate Binding Site II [chemical binding]; other site 863638003212 Substrate Binding Site I [chemical binding]; other site 863638003213 argininosuccinate lyase; Provisional; Region: PRK00855 863638003214 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 863638003215 active sites [active] 863638003216 tetramer interface [polypeptide binding]; other site 863638003217 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 863638003218 active site 863638003219 metal-binding site [ion binding] 863638003220 nucleotide-binding site [chemical binding]; other site 863638003221 Uncharacterized conserved protein [Function unknown]; Region: COG2155 863638003222 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 863638003223 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 863638003224 putative DNA binding site [nucleotide binding]; other site 863638003225 putative Zn2+ binding site [ion binding]; other site 863638003226 AsnC family; Region: AsnC_trans_reg; pfam01037 863638003227 RNase_H superfamily; Region: RNase_H_2; pfam13482 863638003228 active site 863638003229 substrate binding site [chemical binding]; other site 863638003230 FOG: CBS domain [General function prediction only]; Region: COG0517 863638003231 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 863638003232 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 863638003233 Pyruvate formate lyase 1; Region: PFL1; cd01678 863638003234 coenzyme A binding site [chemical binding]; other site 863638003235 active site 863638003236 catalytic residues [active] 863638003237 glycine loop; other site 863638003238 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 863638003239 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638003240 FeS/SAM binding site; other site 863638003241 PilZ domain; Region: PilZ; pfam07238 863638003242 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 863638003243 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 863638003244 Walker A/P-loop; other site 863638003245 ATP binding site [chemical binding]; other site 863638003246 Q-loop/lid; other site 863638003247 ABC transporter signature motif; other site 863638003248 Walker B; other site 863638003249 D-loop; other site 863638003250 H-loop/switch region; other site 863638003251 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 863638003252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638003253 dimer interface [polypeptide binding]; other site 863638003254 conserved gate region; other site 863638003255 ABC-ATPase subunit interface; other site 863638003256 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 863638003257 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 863638003258 RNase_H superfamily; Region: RNase_H_2; pfam13482 863638003259 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 863638003260 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 863638003261 active site 863638003262 HIGH motif; other site 863638003263 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 863638003264 active site 863638003265 KMSKS motif; other site 863638003266 intracellular protease, PfpI family; Region: PfpI; TIGR01382 863638003267 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 863638003268 proposed catalytic triad [active] 863638003269 conserved cys residue [active] 863638003270 Protein of unknown function, DUF488; Region: DUF488; pfam04343 863638003271 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 863638003272 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 863638003273 Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Region: Ndk; COG0105 863638003274 multimer interface [polypeptide binding]; other site 863638003275 homoserine dehydrogenase; Provisional; Region: PRK06349 863638003276 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 863638003277 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 863638003278 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 863638003279 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 863638003280 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 863638003281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638003282 catalytic residue [active] 863638003283 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 863638003284 aspartate aminotransferase; Provisional; Region: PRK07568 863638003285 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 863638003286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638003287 homodimer interface [polypeptide binding]; other site 863638003288 catalytic residue [active] 863638003289 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 863638003290 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 863638003291 active site 863638003292 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 863638003293 Part of AAA domain; Region: AAA_19; pfam13245 863638003294 Family description; Region: UvrD_C_2; pfam13538 863638003295 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 863638003296 nudix motif; other site 863638003297 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638003298 Coenzyme A binding pocket [chemical binding]; other site 863638003299 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 863638003300 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 863638003301 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 863638003302 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 863638003303 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 863638003304 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 863638003305 active site 863638003306 metal binding site [ion binding]; metal-binding site 863638003307 Uncharacterized conserved protein [Function unknown]; Region: COG3339 863638003308 Predicted membrane protein [Function unknown]; Region: COG2246 863638003309 GtrA-like protein; Region: GtrA; pfam04138 863638003310 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 863638003311 Cell division protein FtsA; Region: FtsA; smart00842 863638003312 Cell division protein FtsA; Region: FtsA; pfam14450 863638003313 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 863638003314 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 863638003315 metal binding site [ion binding]; metal-binding site 863638003316 dimer interface [polypeptide binding]; other site 863638003317 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 863638003318 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 863638003319 RNA binding surface [nucleotide binding]; other site 863638003320 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 863638003321 active site 863638003322 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 863638003323 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 863638003324 stage V sporulation protein B; Region: spore_V_B; TIGR02900 863638003325 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 863638003326 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 863638003327 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 863638003328 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 863638003329 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 863638003330 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638003331 FeS/SAM binding site; other site 863638003332 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 863638003333 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 863638003334 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 863638003335 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 863638003336 dimerization interface [polypeptide binding]; other site 863638003337 active site 863638003338 L-aspartate oxidase; Provisional; Region: PRK06175 863638003339 FAD binding domain; Region: FAD_binding_2; pfam00890 863638003340 Quinolinate synthetase A protein; Region: NadA; pfam02445 863638003341 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 863638003342 Part of AAA domain; Region: AAA_19; pfam13245 863638003343 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 863638003344 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 863638003345 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 863638003346 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 863638003347 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 863638003348 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 863638003349 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 863638003350 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 863638003351 G1 box; other site 863638003352 GTP/Mg2+ binding site [chemical binding]; other site 863638003353 Switch I region; other site 863638003354 G2 box; other site 863638003355 G3 box; other site 863638003356 Switch II region; other site 863638003357 G4 box; other site 863638003358 G5 box; other site 863638003359 Nucleoside recognition; Region: Gate; pfam07670 863638003360 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 863638003361 Nucleoside recognition; Region: Gate; pfam07670 863638003362 CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655 863638003363 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 863638003364 active site 863638003365 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 863638003366 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 863638003367 domain interfaces; other site 863638003368 active site 863638003369 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 863638003370 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 863638003371 NodB motif; other site 863638003372 active site 863638003373 catalytic site [active] 863638003374 Zn binding site [ion binding]; other site 863638003375 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 863638003376 Double zinc ribbon; Region: DZR; pfam12773 863638003377 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 863638003378 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 863638003379 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 863638003380 active site 863638003381 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 863638003382 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 863638003383 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 863638003384 active site 863638003385 HIGH motif; other site 863638003386 KMSK motif region; other site 863638003387 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 863638003388 tRNA binding surface [nucleotide binding]; other site 863638003389 anticodon binding site; other site 863638003390 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638003391 non-specific DNA binding site [nucleotide binding]; other site 863638003392 salt bridge; other site 863638003393 sequence-specific DNA binding site [nucleotide binding]; other site 863638003394 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 863638003395 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 863638003396 active site 863638003397 FMN binding site [chemical binding]; other site 863638003398 substrate binding site [chemical binding]; other site 863638003399 putative catalytic residue [active] 863638003400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 863638003401 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 863638003402 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 863638003403 EamA-like transporter family; Region: EamA; pfam00892 863638003404 Transcriptional regulator [Transcription]; Region: LysR; COG0583 863638003405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 863638003406 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 863638003407 dimerization interface [polypeptide binding]; other site 863638003408 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 863638003409 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 863638003410 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 863638003411 active site 863638003412 dimer interface [polypeptide binding]; other site 863638003413 effector binding site; other site 863638003414 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 863638003415 TSCPD domain; Region: TSCPD; pfam12637 863638003416 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 863638003417 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 863638003418 trimer interface [polypeptide binding]; other site 863638003419 putative metal binding site [ion binding]; other site 863638003420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728 863638003421 NAD synthetase; Reviewed; Region: nadE; PRK02628 863638003422 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 863638003423 multimer interface [polypeptide binding]; other site 863638003424 active site 863638003425 catalytic triad [active] 863638003426 protein interface 1 [polypeptide binding]; other site 863638003427 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 863638003428 homodimer interface [polypeptide binding]; other site 863638003429 NAD binding pocket [chemical binding]; other site 863638003430 ATP binding pocket [chemical binding]; other site 863638003431 Mg binding site [ion binding]; other site 863638003432 active-site loop [active] 863638003433 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 863638003434 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 863638003435 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 863638003436 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638003437 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 863638003438 Arginase family; Region: Arginase; cd09989 863638003439 active site 863638003440 Mn binding site [ion binding]; other site 863638003441 oligomer interface [polypeptide binding]; other site 863638003442 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 863638003443 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 863638003444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638003445 binding surface 863638003446 TPR motif; other site 863638003447 TPR repeat; Region: TPR_11; pfam13414 863638003448 TPR repeat; Region: TPR_11; pfam13414 863638003449 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638003450 TPR motif; other site 863638003451 TPR repeat; Region: TPR_11; pfam13414 863638003452 binding surface 863638003453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638003454 binding surface 863638003455 TPR motif; other site 863638003456 TPR repeat; Region: TPR_11; pfam13414 863638003457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638003458 binding surface 863638003459 TPR motif; other site 863638003460 TPR repeat; Region: TPR_11; pfam13414 863638003461 Tetratricopeptide repeat; Region: TPR_12; pfam13424 863638003462 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638003463 binding surface 863638003464 TPR repeat; Region: TPR_11; pfam13414 863638003465 TPR motif; other site 863638003466 Tetratricopeptide repeat; Region: TPR_12; pfam13424 863638003467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638003468 binding surface 863638003469 TPR motif; other site 863638003470 TPR repeat; Region: TPR_11; pfam13414 863638003471 HEAT repeats; Region: HEAT_2; pfam13646 863638003472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638003473 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 863638003474 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 863638003475 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 863638003476 Coenzyme A binding pocket [chemical binding]; other site 863638003477 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 863638003478 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638003479 Radical SAM superfamily; Region: Radical_SAM; pfam04055 863638003480 FeS/SAM binding site; other site 863638003481 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 863638003482 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 863638003483 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 863638003484 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 863638003485 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 863638003486 homotrimer interaction site [polypeptide binding]; other site 863638003487 putative active site [active] 863638003488 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 863638003489 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 863638003490 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 863638003491 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 863638003492 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 863638003493 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 863638003494 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 863638003495 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 863638003496 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 863638003497 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 863638003498 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 863638003499 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 863638003500 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 863638003501 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 863638003502 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 863638003503 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 863638003504 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 863638003505 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 863638003506 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 863638003507 Cna protein B-type domain; Region: Cna_B_2; pfam13715 863638003508 Cna protein B-type domain; Region: Cna_B_2; pfam13715 863638003509 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 863638003510 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 863638003511 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 863638003512 beta-galactosidase; Region: BGL; TIGR03356 863638003513 putative alpha-glucosidase; Provisional; Region: PRK10658 863638003514 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 863638003515 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 863638003516 active site 863638003517 homotrimer interface [polypeptide binding]; other site 863638003518 catalytic site [active] 863638003519 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 863638003520 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 863638003521 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 863638003522 nucleotide binding site [chemical binding]; other site 863638003523 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 863638003524 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 863638003525 putative active site [active] 863638003526 HPr kinase/phosphorylase; Provisional; Region: PRK05428 863638003527 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 863638003528 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 863638003529 Hpr binding site; other site 863638003530 active site 863638003531 homohexamer subunit interaction site [polypeptide binding]; other site 863638003532 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 863638003533 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 863638003534 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 863638003535 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 863638003536 oligomer interface [polypeptide binding]; other site 863638003537 putative active site [active] 863638003538 metal binding site [ion binding]; metal-binding site 863638003539 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 863638003540 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 863638003541 active site 863638003542 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 863638003543 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 863638003544 Cation efflux family; Region: Cation_efflux; pfam01545 863638003545 Predicted membrane protein [Function unknown]; Region: COG2733 863638003546 Predicted membrane protein [Function unknown]; Region: COG2733 863638003547 DNA polymerase I; Provisional; Region: PRK05755 863638003548 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 863638003549 active site 863638003550 metal binding site 1 [ion binding]; metal-binding site 863638003551 putative 5' ssDNA interaction site; other site 863638003552 metal binding site 3; metal-binding site 863638003553 metal binding site 2 [ion binding]; metal-binding site 863638003554 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 863638003555 putative DNA binding site [nucleotide binding]; other site 863638003556 putative metal binding site [ion binding]; other site 863638003557 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 863638003558 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 863638003559 active site 863638003560 DNA binding site [nucleotide binding] 863638003561 catalytic site [active] 863638003562 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 863638003563 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 863638003564 CoA-binding site [chemical binding]; other site 863638003565 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 863638003566 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 863638003567 N-acetyl-D-glucosamine binding site [chemical binding]; other site 863638003568 catalytic residue [active] 863638003569 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 863638003570 Spc7 kinetochore protein; Region: Spc7; smart00787 863638003571 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 863638003572 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 863638003573 active site 863638003574 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 863638003575 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 863638003576 Haemolysin XhlA; Region: XhlA; pfam10779 863638003577 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 863638003578 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 863638003579 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 863638003580 active site 863638003581 catalytic residues [active] 863638003582 DNA binding site [nucleotide binding] 863638003583 Int/Topo IB signature motif; other site 863638003584 Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; cl10351 863638003585 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 863638003586 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 863638003587 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 863638003588 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 863638003589 N-acetyl-D-glucosamine binding site [chemical binding]; other site 863638003590 catalytic residue [active] 863638003591 Bacterial Ig-like domain; Region: Big_5; pfam13205 863638003592 large terminase protein; Provisional; Region: 17; PHA02533 863638003593 Terminase-like family; Region: Terminase_6; pfam03237 863638003594 RNA dependent RNA polymerase; Region: RdRP; pfam05183 863638003595 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 863638003596 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 863638003597 ATP binding site [chemical binding]; other site 863638003598 Family description; Region: UvrD_C_2; pfam13538 863638003599 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 863638003600 AAA domain; Region: AAA_30; pfam13604 863638003601 Family description; Region: UvrD_C_2; pfam13538 863638003602 Domain of unknown function (DUF4121); Region: DUF4121; pfam13497 863638003603 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 863638003604 Mg binding site [ion binding]; other site 863638003605 nucleotide binding site [chemical binding]; other site 863638003606 putative protofilament interface [polypeptide binding]; other site 863638003607 Protein of unknown function DUF262; Region: DUF262; pfam03235 863638003608 Uncharacterized conserved protein [Function unknown]; Region: COG1479 863638003609 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 863638003610 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 863638003611 active site 863638003612 DNA binding site [nucleotide binding] 863638003613 Int/Topo IB signature motif; other site 863638003614 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 863638003615 generic binding surface II; other site 863638003616 AAA domain; Region: AAA_24; pfam13479 863638003617 3D domain; Region: 3D; cl01439 863638003618 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 863638003619 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 863638003620 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 863638003621 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 863638003622 nucleotide binding pocket [chemical binding]; other site 863638003623 K-X-D-G motif; other site 863638003624 catalytic site [active] 863638003625 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 863638003626 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 863638003627 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 863638003628 Dimer interface [polypeptide binding]; other site 863638003629 BRCT sequence motif; other site 863638003630 hypothetical protein; Provisional; Region: PRK08624 863638003631 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 863638003632 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 863638003633 interdomain interaction site; other site 863638003634 active site 863638003635 metal binding site [ion binding]; metal-binding site 863638003636 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 863638003637 DHH family; Region: DHH; pfam01368 863638003638 DHHA1 domain; Region: DHHA1; pfam02272 863638003639 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 863638003640 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 863638003641 Active Sites [active] 863638003642 GIY-YIG domain of uncharacterized hypothetical protein found in phycodnavirus PBCV-1 DNA virus, T. thermophila Tlr element eoncoding protein Tlr8p, and similar proteins found in bacteria; Region: GIY-YIG_HE_Tlr8p_PBC-V_like; cd10443 863638003643 GIY-YIG motif/motif A; other site 863638003644 putative active site [active] 863638003645 putative metal binding site [ion binding]; other site 863638003646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4728 863638003647 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 863638003648 ATP cone domain; Region: ATP-cone; pfam03477 863638003649 Class III ribonucleotide reductase; Region: RNR_III; cd01675 863638003650 effector binding site; other site 863638003651 active site 863638003652 Zn binding site [ion binding]; other site 863638003653 glycine loop; other site 863638003654 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 863638003655 trimer interface [polypeptide binding]; other site 863638003656 active site 863638003657 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638003658 non-specific DNA binding site [nucleotide binding]; other site 863638003659 salt bridge; other site 863638003660 sequence-specific DNA binding site [nucleotide binding]; other site 863638003661 Tetratricopeptide repeat; Region: TPR_12; pfam13424 863638003662 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 863638003663 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 863638003664 active site 863638003665 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 863638003666 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 863638003667 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 863638003668 cofactor binding site; other site 863638003669 DNA binding site [nucleotide binding] 863638003670 substrate interaction site [chemical binding]; other site 863638003671 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 863638003672 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 863638003673 active site 863638003674 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 863638003675 generic binding surface II; other site 863638003676 generic binding surface I; other site 863638003677 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 863638003678 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 863638003679 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 863638003680 DNA binding residues [nucleotide binding] 863638003681 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 863638003682 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 863638003683 putative catalytic residues [active] 863638003684 catalytic nucleophile [active] 863638003685 Recombinase; Region: Recombinase; pfam07508 863638003686 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 863638003687 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 863638003688 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 863638003689 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 863638003690 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 863638003691 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 863638003692 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 863638003693 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 863638003694 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 863638003695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638003696 active site 863638003697 phosphorylation site [posttranslational modification] 863638003698 intermolecular recognition site; other site 863638003699 dimerization interface [polypeptide binding]; other site 863638003700 hypothetical protein; Provisional; Region: PRK04435 863638003701 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 863638003702 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 863638003703 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 863638003704 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 863638003705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 863638003706 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 863638003707 Maf-like protein; Reviewed; Region: PRK00078 863638003708 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 863638003709 active site 863638003710 dimer interface [polypeptide binding]; other site 863638003711 hypothetical protein; Reviewed; Region: PRK00024 863638003712 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 863638003713 MPN+ (JAMM) motif; other site 863638003714 Zinc-binding site [ion binding]; other site 863638003715 rod shape-determining protein MreB; Provisional; Region: PRK13927 863638003716 MreB and similar proteins; Region: MreB_like; cd10225 863638003717 nucleotide binding site [chemical binding]; other site 863638003718 Mg binding site [ion binding]; other site 863638003719 putative protofilament interaction site [polypeptide binding]; other site 863638003720 RodZ interaction site [polypeptide binding]; other site 863638003721 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 863638003722 rod shape-determining protein MreC; Region: MreC; pfam04085 863638003723 rod shape-determining protein MreD; Region: MreD; pfam04093 863638003724 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 863638003725 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 863638003726 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 863638003727 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 863638003728 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 863638003729 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 863638003730 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 863638003731 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 863638003732 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 863638003733 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 863638003734 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 863638003735 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 863638003736 septum formation inhibitor; Reviewed; Region: minC; PRK00513 863638003737 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 863638003738 septum site-determining protein MinD; Region: minD_bact; TIGR01968 863638003739 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 863638003740 Switch I; other site 863638003741 Switch II; other site 863638003742 cell division topological specificity factor MinE; Provisional; Region: PRK13987 863638003743 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 863638003744 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 863638003745 Peptidase family M23; Region: Peptidase_M23; pfam01551 863638003746 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 863638003747 Peptidase family M50; Region: Peptidase_M50; pfam02163 863638003748 active site 863638003749 putative substrate binding region [chemical binding]; other site 863638003750 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 863638003751 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 863638003752 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638003753 FeS/SAM binding site; other site 863638003754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5011 863638003755 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 863638003756 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 863638003757 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 863638003758 homodimer interface [polypeptide binding]; other site 863638003759 oligonucleotide binding site [chemical binding]; other site 863638003760 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 863638003761 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 863638003762 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 863638003763 GTPase CgtA; Reviewed; Region: obgE; PRK12297 863638003764 GTP1/OBG; Region: GTP1_OBG; pfam01018 863638003765 Obg GTPase; Region: Obg; cd01898 863638003766 G1 box; other site 863638003767 GTP/Mg2+ binding site [chemical binding]; other site 863638003768 Switch I region; other site 863638003769 G2 box; other site 863638003770 G3 box; other site 863638003771 Switch II region; other site 863638003772 G4 box; other site 863638003773 G5 box; other site 863638003774 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 863638003775 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 863638003776 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 863638003777 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 863638003778 active site 863638003779 (T/H)XGH motif; other site 863638003780 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638003781 Zn2+ binding site [ion binding]; other site 863638003782 Mg2+ binding site [ion binding]; other site 863638003783 Transcriptional regulator [Transcription]; Region: LytR; COG1316 863638003784 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 863638003785 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 863638003786 homotrimer interaction site [polypeptide binding]; other site 863638003787 putative active site [active] 863638003788 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 863638003789 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 863638003790 RNA binding surface [nucleotide binding]; other site 863638003791 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 863638003792 active site 863638003793 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 863638003794 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 863638003795 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 863638003796 SLBB domain; Region: SLBB; pfam10531 863638003797 comEA protein; Region: comE; TIGR01259 863638003798 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 863638003799 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 863638003800 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 863638003801 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 863638003802 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 863638003803 Competence protein; Region: Competence; pfam03772 863638003804 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 863638003805 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 863638003806 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 863638003807 GPR endopeptidase; Region: GPR; TIGR01441 863638003808 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 863638003809 stage II sporulation protein P; Region: spore_II_P; TIGR02867 863638003810 GTP-binding protein LepA; Provisional; Region: PRK05433 863638003811 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 863638003812 G1 box; other site 863638003813 putative GEF interaction site [polypeptide binding]; other site 863638003814 GTP/Mg2+ binding site [chemical binding]; other site 863638003815 Switch I region; other site 863638003816 G2 box; other site 863638003817 G3 box; other site 863638003818 Switch II region; other site 863638003819 G4 box; other site 863638003820 G5 box; other site 863638003821 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 863638003822 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 863638003823 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 863638003824 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 863638003825 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638003826 FeS/SAM binding site; other site 863638003827 HemN C-terminal domain; Region: HemN_C; pfam06969 863638003828 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 863638003829 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 863638003830 GrpE; Region: GrpE; pfam01025 863638003831 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 863638003832 dimer interface [polypeptide binding]; other site 863638003833 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 863638003834 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 863638003835 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 863638003836 nucleotide binding site [chemical binding]; other site 863638003837 NEF interaction site [polypeptide binding]; other site 863638003838 SBD interface [polypeptide binding]; other site 863638003839 chaperone protein DnaJ; Provisional; Region: PRK14297 863638003840 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 863638003841 HSP70 interaction site [polypeptide binding]; other site 863638003842 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 863638003843 substrate binding site [polypeptide binding]; other site 863638003844 dimer interface [polypeptide binding]; other site 863638003845 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 863638003846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638003847 S-adenosylmethionine binding site [chemical binding]; other site 863638003848 RNA methyltransferase, RsmE family; Region: TIGR00046 863638003849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 863638003850 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 863638003851 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 863638003852 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638003853 FeS/SAM binding site; other site 863638003854 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 863638003855 nucleotide binding site/active site [active] 863638003856 HIT family signature motif; other site 863638003857 catalytic residue [active] 863638003858 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 863638003859 Yqey-like protein; Region: YqeY; pfam09424 863638003860 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 863638003861 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 863638003862 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 863638003863 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 863638003864 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 863638003865 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638003866 Zn2+ binding site [ion binding]; other site 863638003867 Mg2+ binding site [ion binding]; other site 863638003868 metal-binding heat shock protein; Provisional; Region: PRK00016 863638003869 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 863638003870 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 863638003871 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 863638003872 active site 863638003873 GTPase Era; Reviewed; Region: era; PRK00089 863638003874 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 863638003875 G1 box; other site 863638003876 GTP/Mg2+ binding site [chemical binding]; other site 863638003877 Switch I region; other site 863638003878 G2 box; other site 863638003879 Switch II region; other site 863638003880 G3 box; other site 863638003881 G4 box; other site 863638003882 G5 box; other site 863638003883 KH domain; Region: KH_2; pfam07650 863638003884 Recombination protein O N terminal; Region: RecO_N; pfam11967 863638003885 DNA repair protein RecO; Region: reco; TIGR00613 863638003886 Recombination protein O C terminal; Region: RecO_C; pfam02565 863638003887 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 863638003888 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 863638003889 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 863638003890 DNA primase; Validated; Region: dnaG; PRK05667 863638003891 CHC2 zinc finger; Region: zf-CHC2; pfam01807 863638003892 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 863638003893 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 863638003894 active site 863638003895 metal binding site [ion binding]; metal-binding site 863638003896 interdomain interaction site; other site 863638003897 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 863638003898 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 863638003899 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 863638003900 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 863638003901 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 863638003902 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 863638003903 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 863638003904 DNA binding residues [nucleotide binding] 863638003905 Protein of unknown function (DUF2679); Region: DUF2679; pfam10882 863638003906 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 863638003907 Family of unknown function (DUF633); Region: DUF633; pfam04816 863638003908 Uncharacterized conserved protein [Function unknown]; Region: COG0327 863638003909 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 863638003910 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 863638003911 Putative zinc ribbon domain; Region: DUF164; pfam02591 863638003912 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 863638003913 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 863638003914 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 863638003915 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 863638003916 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 863638003917 DNA binding site [nucleotide binding] 863638003918 Int/Topo IB signature motif; other site 863638003919 active site 863638003920 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 863638003921 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 863638003922 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 863638003923 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 863638003924 Ion channel; Region: Ion_trans_2; pfam07885 863638003925 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 863638003926 amphipathic channel; other site 863638003927 Asn-Pro-Ala signature motifs; other site 863638003928 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 863638003929 glycerol kinase; Provisional; Region: glpK; PRK00047 863638003930 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 863638003931 N- and C-terminal domain interface [polypeptide binding]; other site 863638003932 active site 863638003933 MgATP binding site [chemical binding]; other site 863638003934 catalytic site [active] 863638003935 metal binding site [ion binding]; metal-binding site 863638003936 glycerol binding site [chemical binding]; other site 863638003937 homotetramer interface [polypeptide binding]; other site 863638003938 homodimer interface [polypeptide binding]; other site 863638003939 FBP binding site [chemical binding]; other site 863638003940 protein IIAGlc interface [polypeptide binding]; other site 863638003941 Predicted dehydrogenase [General function prediction only]; Region: COG0579 863638003942 hydroxyglutarate oxidase; Provisional; Region: PRK11728 863638003943 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 863638003944 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 863638003945 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 863638003946 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 863638003947 Uncharacterized conserved protein [Function unknown]; Region: COG1284 863638003948 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 863638003949 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 863638003950 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 863638003951 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 863638003952 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 863638003953 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 863638003954 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 863638003955 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 863638003956 D-mannonate oxidoreductase; Provisional; Region: PRK08277 863638003957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 863638003958 NAD(P) binding site [chemical binding]; other site 863638003959 active site 863638003960 mannonate dehydratase; Provisional; Region: PRK03906 863638003961 mannonate dehydratase; Region: uxuA; TIGR00695 863638003962 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 863638003963 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 863638003964 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 863638003965 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 863638003966 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638003967 Radical SAM superfamily; Region: Radical_SAM; pfam04055 863638003968 FeS/SAM binding site; other site 863638003969 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 863638003970 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 863638003971 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 863638003972 CotJB protein; Region: CotJB; pfam12652 863638003973 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 863638003974 dimanganese center [ion binding]; other site 863638003975 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 863638003976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638003977 putative substrate translocation pore; other site 863638003978 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 863638003979 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 863638003980 DNA-binding site [nucleotide binding]; DNA binding site 863638003981 Transcriptional regulators [Transcription]; Region: PurR; COG1609 863638003982 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 863638003983 putative dimerization interface [polypeptide binding]; other site 863638003984 putative ligand binding site [chemical binding]; other site 863638003985 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 863638003986 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 863638003987 intersubunit interface [polypeptide binding]; other site 863638003988 active site 863638003989 Zn2+ binding site [ion binding]; other site 863638003990 L-arabinose isomerase; Provisional; Region: PRK02929 863638003991 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 863638003992 hexamer (dimer of trimers) interface [polypeptide binding]; other site 863638003993 trimer interface [polypeptide binding]; other site 863638003994 substrate binding site [chemical binding]; other site 863638003995 Mn binding site [ion binding]; other site 863638003996 putative phosphoketolase; Provisional; Region: PRK05261 863638003997 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 863638003998 TPP-binding site; other site 863638003999 XFP C-terminal domain; Region: XFP_C; pfam09363 863638004000 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 863638004001 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 863638004002 putative N- and C-terminal domain interface [polypeptide binding]; other site 863638004003 putative active site [active] 863638004004 MgATP binding site [chemical binding]; other site 863638004005 catalytic site [active] 863638004006 metal binding site [ion binding]; metal-binding site 863638004007 putative carbohydrate binding site [chemical binding]; other site 863638004008 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 863638004009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638004010 putative substrate translocation pore; other site 863638004011 L-arabinose isomerase; Provisional; Region: PRK02929 863638004012 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 863638004013 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 863638004014 trimer interface [polypeptide binding]; other site 863638004015 putative substrate binding site [chemical binding]; other site 863638004016 putative metal binding site [ion binding]; other site 863638004017 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 863638004018 active site 863638004019 intersubunit interactions; other site 863638004020 catalytic residue [active] 863638004021 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 863638004022 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 863638004023 TPP-binding site [chemical binding]; other site 863638004024 dimer interface [polypeptide binding]; other site 863638004025 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 863638004026 PYR/PP interface [polypeptide binding]; other site 863638004027 dimer interface [polypeptide binding]; other site 863638004028 TPP binding site [chemical binding]; other site 863638004029 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 863638004030 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 863638004031 active site 863638004032 catalytic residues [active] 863638004033 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 863638004034 putative active site [active] 863638004035 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 863638004036 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 863638004037 putative ligand binding site [chemical binding]; other site 863638004038 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 863638004039 dimerization interface [polypeptide binding]; other site 863638004040 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 863638004041 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638004042 dimer interface [polypeptide binding]; other site 863638004043 putative CheW interface [polypeptide binding]; other site 863638004044 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 863638004045 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 863638004046 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 863638004047 active site turn [active] 863638004048 phosphorylation site [posttranslational modification] 863638004049 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 863638004050 HPr interaction site; other site 863638004051 glycerol kinase (GK) interaction site [polypeptide binding]; other site 863638004052 active site 863638004053 phosphorylation site [posttranslational modification] 863638004054 transcriptional antiterminator BglG; Provisional; Region: PRK09772 863638004055 CAT RNA binding domain; Region: CAT_RBD; smart01061 863638004056 PRD domain; Region: PRD; pfam00874 863638004057 PRD domain; Region: PRD; pfam00874 863638004058 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 863638004059 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638004060 FeS/SAM binding site; other site 863638004061 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 863638004062 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 863638004063 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 863638004064 NodB motif; other site 863638004065 active site 863638004066 catalytic site [active] 863638004067 Zn binding site [ion binding]; other site 863638004068 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 863638004069 AAA domain; Region: AAA_26; pfam13500 863638004070 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 863638004071 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 863638004072 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 863638004073 inhibitor-cofactor binding pocket; inhibition site 863638004074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638004075 catalytic residue [active] 863638004076 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 863638004077 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 863638004078 E-class dimer interface [polypeptide binding]; other site 863638004079 P-class dimer interface [polypeptide binding]; other site 863638004080 active site 863638004081 Cu2+ binding site [ion binding]; other site 863638004082 Zn2+ binding site [ion binding]; other site 863638004083 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 863638004084 PLD-like domain; Region: PLDc_2; pfam13091 863638004085 putative active site [active] 863638004086 catalytic site [active] 863638004087 cobalt transport protein CbiM; Validated; Region: PRK08319 863638004088 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 863638004089 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 863638004090 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 863638004091 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 863638004092 Walker A/P-loop; other site 863638004093 ATP binding site [chemical binding]; other site 863638004094 Q-loop/lid; other site 863638004095 ABC transporter signature motif; other site 863638004096 Walker B; other site 863638004097 D-loop; other site 863638004098 H-loop/switch region; other site 863638004099 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 863638004100 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 863638004101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638004102 homodimer interface [polypeptide binding]; other site 863638004103 catalytic residue [active] 863638004104 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 863638004105 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 863638004106 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 863638004107 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 863638004108 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 863638004109 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 863638004110 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 863638004111 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 863638004112 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 863638004113 putative dimer interface [polypeptide binding]; other site 863638004114 active site pocket [active] 863638004115 putative cataytic base [active] 863638004116 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 863638004117 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 863638004118 active site 863638004119 C-terminal domain interface [polypeptide binding]; other site 863638004120 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 863638004121 active site 863638004122 N-terminal domain interface [polypeptide binding]; other site 863638004123 cobyric acid synthase; Provisional; Region: PRK00784 863638004124 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 863638004125 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 863638004126 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 863638004127 catalytic triad [active] 863638004128 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797 863638004129 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 863638004130 catalytic triad [active] 863638004131 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 863638004132 precorrin-8X methylmutase; Validated; Region: cbiC; PRK05575 863638004133 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 863638004134 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 863638004135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638004136 S-adenosylmethionine binding site [chemical binding]; other site 863638004137 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 863638004138 active site 863638004139 SAM binding site [chemical binding]; other site 863638004140 homodimer interface [polypeptide binding]; other site 863638004141 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 863638004142 active site 863638004143 SAM binding site [chemical binding]; other site 863638004144 homodimer interface [polypeptide binding]; other site 863638004145 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 863638004146 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 863638004147 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 863638004148 active site 863638004149 SAM binding site [chemical binding]; other site 863638004150 homodimer interface [polypeptide binding]; other site 863638004151 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 863638004152 homotrimer interface [polypeptide binding]; other site 863638004153 Walker A motif; other site 863638004154 GTP binding site [chemical binding]; other site 863638004155 Walker B motif; other site 863638004156 cobalamin synthase; Reviewed; Region: cobS; PRK00235 863638004157 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 863638004158 catalytic core [active] 863638004159 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 863638004160 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 863638004161 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 863638004162 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638004163 dimerization interface [polypeptide binding]; other site 863638004164 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638004165 dimer interface [polypeptide binding]; other site 863638004166 putative CheW interface [polypeptide binding]; other site 863638004167 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 863638004168 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 863638004169 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638004170 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638004171 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638004172 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638004173 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638004174 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638004175 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638004176 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638004177 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638004178 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638004179 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638004180 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 863638004181 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 863638004182 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 863638004183 ATP binding site [chemical binding]; other site 863638004184 active site 863638004185 substrate binding site [chemical binding]; other site 863638004186 amidophosphoribosyltransferase; Provisional; Region: PRK05793 863638004187 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 863638004188 active site 863638004189 tetramer interface [polypeptide binding]; other site 863638004190 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 863638004191 active site 863638004192 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 863638004193 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 863638004194 dimerization interface [polypeptide binding]; other site 863638004195 putative ATP binding site [chemical binding]; other site 863638004196 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 863638004197 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 863638004198 active site 863638004199 substrate binding site [chemical binding]; other site 863638004200 cosubstrate binding site; other site 863638004201 catalytic site [active] 863638004202 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 863638004203 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 863638004204 purine monophosphate binding site [chemical binding]; other site 863638004205 dimer interface [polypeptide binding]; other site 863638004206 putative catalytic residues [active] 863638004207 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 863638004208 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 863638004209 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 863638004210 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 863638004211 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 863638004212 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 863638004213 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 863638004214 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 863638004215 active site 863638004216 Domain of unknown function DUF77; Region: DUF77; pfam01910 863638004217 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 863638004218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638004219 dimer interface [polypeptide binding]; other site 863638004220 conserved gate region; other site 863638004221 ABC-ATPase subunit interface; other site 863638004222 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 863638004223 NMT1/THI5 like; Region: NMT1; pfam09084 863638004224 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 863638004225 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 863638004226 Walker A/P-loop; other site 863638004227 ATP binding site [chemical binding]; other site 863638004228 Q-loop/lid; other site 863638004229 ABC transporter signature motif; other site 863638004230 Walker B; other site 863638004231 D-loop; other site 863638004232 H-loop/switch region; other site 863638004233 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 863638004234 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 863638004235 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 863638004236 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 863638004237 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 863638004238 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 863638004239 beta-galactosidase; Region: BGL; TIGR03356 863638004240 CAT RNA binding domain; Region: CAT_RBD; pfam03123 863638004241 transcriptional antiterminator BglG; Provisional; Region: PRK09772 863638004242 PRD domain; Region: PRD; pfam00874 863638004243 PRD domain; Region: PRD; pfam00874 863638004244 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 863638004245 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 863638004246 active site turn [active] 863638004247 phosphorylation site [posttranslational modification] 863638004248 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 863638004249 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 863638004250 HPr interaction site; other site 863638004251 glycerol kinase (GK) interaction site [polypeptide binding]; other site 863638004252 active site 863638004253 phosphorylation site [posttranslational modification] 863638004254 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 863638004255 beta-galactosidase; Region: BGL; TIGR03356 863638004256 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 863638004257 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 863638004258 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 863638004259 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 863638004260 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 863638004261 putative metal binding site [ion binding]; other site 863638004262 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 863638004263 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 863638004264 putative metal binding site [ion binding]; other site 863638004265 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 863638004266 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 863638004267 putative metal binding site [ion binding]; other site 863638004268 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 863638004269 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 863638004270 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638004271 Coenzyme A binding pocket [chemical binding]; other site 863638004272 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 863638004273 putative FMN binding site [chemical binding]; other site 863638004274 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 863638004275 putative dimer interface [polypeptide binding]; other site 863638004276 catalytic triad [active] 863638004277 hypothetical protein; Provisional; Region: PRK03881 863638004278 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 863638004279 Uncharacterized conserved protein [Function unknown]; Region: AMMECR1; COG2078 863638004280 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 863638004281 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638004282 FeS/SAM binding site; other site 863638004283 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 863638004284 Domain of unknown function DUF21; Region: DUF21; pfam01595 863638004285 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 863638004286 Transporter associated domain; Region: CorC_HlyC; smart01091 863638004287 short chain dehydrogenase; Provisional; Region: PRK06701 863638004288 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 863638004289 NAD binding site [chemical binding]; other site 863638004290 metal binding site [ion binding]; metal-binding site 863638004291 active site 863638004292 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 863638004293 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 863638004294 trimer interface [polypeptide binding]; other site 863638004295 active site 863638004296 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 863638004297 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 863638004298 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 863638004299 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 863638004300 inhibitor-cofactor binding pocket; inhibition site 863638004301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638004302 catalytic residue [active] 863638004303 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 863638004304 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 863638004305 NAD binding site [chemical binding]; other site 863638004306 homodimer interface [polypeptide binding]; other site 863638004307 active site 863638004308 substrate binding site [chemical binding]; other site 863638004309 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 863638004310 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 863638004311 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 863638004312 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 863638004313 tetramer (dimer of dimers) interface [polypeptide binding]; other site 863638004314 active site 863638004315 dimer interface [polypeptide binding]; other site 863638004316 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 863638004317 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 863638004318 catalytic residue [active] 863638004319 putative FPP diphosphate binding site; other site 863638004320 putative FPP binding hydrophobic cleft; other site 863638004321 dimer interface [polypeptide binding]; other site 863638004322 putative IPP diphosphate binding site; other site 863638004323 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 863638004324 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 863638004325 Sulfatase; Region: Sulfatase; cl17466 863638004326 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 863638004327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638004328 S-adenosylmethionine binding site [chemical binding]; other site 863638004329 AAA ATPase domain; Region: AAA_16; pfam13191 863638004330 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 863638004331 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 863638004332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638004333 Major Facilitator Superfamily; Region: MFS_1; pfam07690 863638004334 putative substrate translocation pore; other site 863638004335 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 863638004336 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 863638004337 G1 box; other site 863638004338 putative GEF interaction site [polypeptide binding]; other site 863638004339 GTP/Mg2+ binding site [chemical binding]; other site 863638004340 Switch I region; other site 863638004341 G2 box; other site 863638004342 G3 box; other site 863638004343 Switch II region; other site 863638004344 G4 box; other site 863638004345 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 863638004346 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 863638004347 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 863638004348 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 863638004349 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 863638004350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 863638004351 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 863638004352 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 863638004353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638004354 Major Facilitator Superfamily; Region: MFS_1; pfam07690 863638004355 putative substrate translocation pore; other site 863638004356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638004357 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 863638004358 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 863638004359 ligand binding site [chemical binding]; other site 863638004360 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 863638004361 Histidine kinase; Region: HisKA_3; pfam07730 863638004362 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 863638004363 Mg2+ binding site [ion binding]; other site 863638004364 G-X-G motif; other site 863638004365 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 863638004366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638004367 active site 863638004368 phosphorylation site [posttranslational modification] 863638004369 intermolecular recognition site; other site 863638004370 dimerization interface [polypeptide binding]; other site 863638004371 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 863638004372 dimerization interface [polypeptide binding]; other site 863638004373 DNA binding residues [nucleotide binding] 863638004374 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 863638004375 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 863638004376 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 863638004377 active pocket/dimerization site; other site 863638004378 active site 863638004379 phosphorylation site [posttranslational modification] 863638004380 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 863638004381 active site 863638004382 phosphorylation site [posttranslational modification] 863638004383 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 863638004384 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 863638004385 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 863638004386 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 863638004387 substrate binding [chemical binding]; other site 863638004388 active site 863638004389 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 863638004390 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 863638004391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638004392 sequence-specific DNA binding site [nucleotide binding]; other site 863638004393 salt bridge; other site 863638004394 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 863638004395 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 863638004396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638004397 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 863638004398 Walker A/P-loop; other site 863638004399 ATP binding site [chemical binding]; other site 863638004400 Q-loop/lid; other site 863638004401 ABC transporter signature motif; other site 863638004402 Walker B; other site 863638004403 D-loop; other site 863638004404 H-loop/switch region; other site 863638004405 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 863638004406 MarR family; Region: MarR_2; pfam12802 863638004407 Uncharacterized conserved protein [Function unknown]; Region: COG2128 863638004408 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 863638004409 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 863638004410 putative DNA binding site [nucleotide binding]; other site 863638004411 putative Zn2+ binding site [ion binding]; other site 863638004412 AsnC family; Region: AsnC_trans_reg; pfam01037 863638004413 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 863638004414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638004415 Coenzyme A binding pocket [chemical binding]; other site 863638004416 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 863638004417 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 863638004418 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 863638004419 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 863638004420 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 863638004421 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 863638004422 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 863638004423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638004424 dimer interface [polypeptide binding]; other site 863638004425 conserved gate region; other site 863638004426 putative PBP binding loops; other site 863638004427 ABC-ATPase subunit interface; other site 863638004428 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 863638004429 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 863638004430 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 863638004431 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 863638004432 Walker A/P-loop; other site 863638004433 ATP binding site [chemical binding]; other site 863638004434 Q-loop/lid; other site 863638004435 ABC transporter signature motif; other site 863638004436 Walker B; other site 863638004437 D-loop; other site 863638004438 H-loop/switch region; other site 863638004439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638004440 dimer interface [polypeptide binding]; other site 863638004441 conserved gate region; other site 863638004442 putative PBP binding loops; other site 863638004443 ABC-ATPase subunit interface; other site 863638004444 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 863638004445 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 863638004446 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 863638004447 RNA binding surface [nucleotide binding]; other site 863638004448 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 863638004449 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 863638004450 homodimer interface [polypeptide binding]; other site 863638004451 substrate-cofactor binding pocket; other site 863638004452 catalytic residue [active] 863638004453 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 863638004454 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 863638004455 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 863638004456 Transcriptional regulator [Transcription]; Region: LysR; COG0583 863638004457 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 863638004458 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 863638004459 dimerization interface [polypeptide binding]; other site 863638004460 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 863638004461 Predicted transcriptional regulators [Transcription]; Region: COG1733 863638004462 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 863638004463 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 863638004464 putative FMN binding site [chemical binding]; other site 863638004465 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 863638004466 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 863638004467 DXD motif; other site 863638004468 PilZ domain; Region: PilZ; pfam07238 863638004469 Uncharacterized protein family (UPF0180); Region: UPF0180; pfam03698 863638004470 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 863638004471 putative glycosyl transferase; Provisional; Region: PRK10073 863638004472 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 863638004473 active site 863638004474 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 863638004475 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 863638004476 active site 863638004477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 863638004478 Pirin-related protein [General function prediction only]; Region: COG1741 863638004479 Pirin; Region: Pirin; pfam02678 863638004480 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 863638004481 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 863638004482 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 863638004483 RibD C-terminal domain; Region: RibD_C; cl17279 863638004484 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 863638004485 Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541 863638004486 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 863638004487 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 863638004488 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 863638004489 endonuclease III; Region: ENDO3c; smart00478 863638004490 minor groove reading motif; other site 863638004491 helix-hairpin-helix signature motif; other site 863638004492 substrate binding pocket [chemical binding]; other site 863638004493 active site 863638004494 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 863638004495 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 863638004496 cofactor binding site; other site 863638004497 DNA binding site [nucleotide binding] 863638004498 substrate interaction site [chemical binding]; other site 863638004499 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 863638004500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638004501 putative substrate translocation pore; other site 863638004502 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638004503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638004504 active site 863638004505 phosphorylation site [posttranslational modification] 863638004506 intermolecular recognition site; other site 863638004507 dimerization interface [polypeptide binding]; other site 863638004508 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638004509 DNA binding site [nucleotide binding] 863638004510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638004511 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638004512 dimerization interface [polypeptide binding]; other site 863638004513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638004514 dimer interface [polypeptide binding]; other site 863638004515 phosphorylation site [posttranslational modification] 863638004516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638004517 ATP binding site [chemical binding]; other site 863638004518 Mg2+ binding site [ion binding]; other site 863638004519 G-X-G motif; other site 863638004520 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 863638004521 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 863638004522 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 863638004523 DNA binding residues [nucleotide binding] 863638004524 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 863638004525 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 863638004526 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 863638004527 ligand binding site [chemical binding]; other site 863638004528 flexible hinge region; other site 863638004529 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 863638004530 putative switch regulator; other site 863638004531 non-specific DNA interactions [nucleotide binding]; other site 863638004532 DNA binding site [nucleotide binding] 863638004533 sequence specific DNA binding site [nucleotide binding]; other site 863638004534 putative cAMP binding site [chemical binding]; other site 863638004535 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 863638004536 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 863638004537 sulfite reductase, subunit B; Region: sulfite_red_B; TIGR02911 863638004538 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 863638004539 FAD binding pocket [chemical binding]; other site 863638004540 FAD binding motif [chemical binding]; other site 863638004541 phosphate binding motif [ion binding]; other site 863638004542 beta-alpha-beta structure motif; other site 863638004543 NAD binding pocket [chemical binding]; other site 863638004544 Iron coordination center [ion binding]; other site 863638004545 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 863638004546 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 863638004547 4Fe-4S binding domain; Region: Fer4; pfam00037 863638004548 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638004549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638004550 active site 863638004551 phosphorylation site [posttranslational modification] 863638004552 intermolecular recognition site; other site 863638004553 dimerization interface [polypeptide binding]; other site 863638004554 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638004555 DNA binding site [nucleotide binding] 863638004556 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638004557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638004558 dimer interface [polypeptide binding]; other site 863638004559 phosphorylation site [posttranslational modification] 863638004560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638004561 ATP binding site [chemical binding]; other site 863638004562 Mg2+ binding site [ion binding]; other site 863638004563 G-X-G motif; other site 863638004564 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638004565 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 863638004566 Walker A/P-loop; other site 863638004567 ATP binding site [chemical binding]; other site 863638004568 Q-loop/lid; other site 863638004569 ABC transporter signature motif; other site 863638004570 Walker B; other site 863638004571 D-loop; other site 863638004572 H-loop/switch region; other site 863638004573 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 863638004574 FtsX-like permease family; Region: FtsX; pfam02687 863638004575 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 863638004576 FtsX-like permease family; Region: FtsX; pfam02687 863638004577 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 863638004578 Predicted membrane protein [Function unknown]; Region: COG2323 863638004579 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 863638004580 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 863638004581 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 863638004582 nucleotide binding site [chemical binding]; other site 863638004583 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638004584 dimer interface [polypeptide binding]; other site 863638004585 putative CheW interface [polypeptide binding]; other site 863638004586 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 863638004587 dimer interface [polypeptide binding]; other site 863638004588 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 863638004589 CHAP domain; Region: CHAP; pfam05257 863638004590 Spore germination protein; Region: Spore_permease; pfam03845 863638004591 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 863638004592 active site 863638004593 galactoside permease; Reviewed; Region: lacY; PRK09528 863638004594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638004595 putative substrate translocation pore; other site 863638004596 Uncharacterized conserved protein [Function unknown]; Region: COG2461 863638004597 Family of unknown function (DUF438); Region: DUF438; pfam04282 863638004598 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 863638004599 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638004600 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638004601 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638004602 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638004603 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638004604 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638004605 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638004606 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 863638004607 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 863638004608 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 863638004609 FtsX-like permease family; Region: FtsX; pfam02687 863638004610 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638004611 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 863638004612 Walker A/P-loop; other site 863638004613 ATP binding site [chemical binding]; other site 863638004614 Q-loop/lid; other site 863638004615 ABC transporter signature motif; other site 863638004616 Walker B; other site 863638004617 D-loop; other site 863638004618 H-loop/switch region; other site 863638004619 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638004620 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638004621 Uncharacterized conserved protein [Function unknown]; Region: COG2013 863638004622 EamA-like transporter family; Region: EamA; pfam00892 863638004623 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 863638004624 EamA-like transporter family; Region: EamA; pfam00892 863638004625 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG2918 863638004626 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 863638004627 ATP-grasp domain; Region: ATP-grasp_4; cl17255 863638004628 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 863638004629 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 863638004630 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 863638004631 putative ligand binding site [chemical binding]; other site 863638004632 putative NAD binding site [chemical binding]; other site 863638004633 catalytic site [active] 863638004634 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 863638004635 active site 863638004636 catalytic motif [active] 863638004637 Zn binding site [ion binding]; other site 863638004638 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 863638004639 intersubunit interface [polypeptide binding]; other site 863638004640 active site 863638004641 catalytic residue [active] 863638004642 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 863638004643 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 863638004644 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 863638004645 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 863638004646 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 863638004647 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 863638004648 catalytic residues [active] 863638004649 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 863638004650 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 863638004651 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 863638004652 catalytic residues [active] 863638004653 dimer interface [polypeptide binding]; other site 863638004654 methionine sulfoxide reductase B; Provisional; Region: PRK00222 863638004655 SelR domain; Region: SelR; pfam01641 863638004656 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 863638004657 putative FMN binding site [chemical binding]; other site 863638004658 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638004659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638004660 active site 863638004661 phosphorylation site [posttranslational modification] 863638004662 intermolecular recognition site; other site 863638004663 dimerization interface [polypeptide binding]; other site 863638004664 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638004665 DNA binding site [nucleotide binding] 863638004666 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638004667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638004668 dimer interface [polypeptide binding]; other site 863638004669 phosphorylation site [posttranslational modification] 863638004670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638004671 ATP binding site [chemical binding]; other site 863638004672 Mg2+ binding site [ion binding]; other site 863638004673 G-X-G motif; other site 863638004674 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 863638004675 metal-binding site [ion binding] 863638004676 Uncharacterized conserved protein [Function unknown]; Region: COG2836 863638004677 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 863638004678 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 863638004679 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 863638004680 flagellin; Provisional; Region: PRK12804 863638004681 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 863638004682 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 863638004683 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 863638004684 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 863638004685 Interdomain contacts; other site 863638004686 Cytokine receptor motif; other site 863638004687 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 863638004688 active site 863638004689 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 863638004690 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 863638004691 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 863638004692 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 863638004693 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638004694 Walker A/P-loop; other site 863638004695 ATP binding site [chemical binding]; other site 863638004696 Q-loop/lid; other site 863638004697 ABC transporter signature motif; other site 863638004698 Walker B; other site 863638004699 D-loop; other site 863638004700 H-loop/switch region; other site 863638004701 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 863638004702 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638004703 non-specific DNA binding site [nucleotide binding]; other site 863638004704 salt bridge; other site 863638004705 sequence-specific DNA binding site [nucleotide binding]; other site 863638004706 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 863638004707 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 863638004708 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 863638004709 DXD motif; other site 863638004710 PilZ domain; Region: PilZ; pfam07238 863638004711 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 863638004712 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 863638004713 DHHW protein; Region: DHHW; pfam14286 863638004714 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 863638004715 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 863638004716 metal binding site [ion binding]; metal-binding site 863638004717 active site 863638004718 I-site; other site 863638004719 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 863638004720 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 863638004721 metal binding site [ion binding]; metal-binding site 863638004722 active site 863638004723 I-site; other site 863638004724 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 863638004725 MarR family; Region: MarR; pfam01047 863638004726 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 863638004727 catalytic residues [active] 863638004728 dimer interface [polypeptide binding]; other site 863638004729 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 863638004730 catalytic residues [active] 863638004731 dimer interface [polypeptide binding]; other site 863638004732 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 863638004733 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 863638004734 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 863638004735 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 863638004736 active site 863638004737 NAD binding site [chemical binding]; other site 863638004738 metal binding site [ion binding]; metal-binding site 863638004739 conserved hypothetical protein; Region: TIGR02328 863638004740 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 863638004741 short chain dehydrogenase; Provisional; Region: PRK06701 863638004742 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 863638004743 NAD binding site [chemical binding]; other site 863638004744 metal binding site [ion binding]; metal-binding site 863638004745 active site 863638004746 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 863638004747 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 863638004748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638004749 non-specific DNA binding site [nucleotide binding]; other site 863638004750 salt bridge; other site 863638004751 sequence-specific DNA binding site [nucleotide binding]; other site 863638004752 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638004753 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 863638004754 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638004755 dimer interface [polypeptide binding]; other site 863638004756 putative CheW interface [polypeptide binding]; other site 863638004757 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 863638004758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638004759 active site 863638004760 phosphorylation site [posttranslational modification] 863638004761 intermolecular recognition site; other site 863638004762 dimerization interface [polypeptide binding]; other site 863638004763 LytTr DNA-binding domain; Region: LytTR; pfam04397 863638004764 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 863638004765 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 863638004766 AAA domain; Region: AAA_17; pfam13207 863638004767 AAA domain; Region: AAA_18; pfam13238 863638004768 ribonuclease Z; Region: RNase_Z; TIGR02651 863638004769 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 863638004770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638004771 putative substrate translocation pore; other site 863638004772 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 863638004773 camphor resistance protein CrcB; Provisional; Region: PRK14232 863638004774 Transcriptional regulator [Transcription]; Region: LysR; COG0583 863638004775 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 863638004776 The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437 863638004777 putative dimerization interface [polypeptide binding]; other site 863638004778 malate dehydrogenase; Provisional; Region: PRK13529 863638004779 Malic enzyme, N-terminal domain; Region: malic; pfam00390 863638004780 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 863638004781 NAD(P) binding site [chemical binding]; other site 863638004782 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 863638004783 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 863638004784 transmembrane helices; other site 863638004785 Predicted membrane protein [Function unknown]; Region: COG3689 863638004786 Predicted permeases [General function prediction only]; Region: COG0701 863638004787 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 863638004788 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 863638004789 metal binding site [ion binding]; metal-binding site 863638004790 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 863638004791 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 863638004792 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 863638004793 RNA binding surface [nucleotide binding]; other site 863638004794 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 863638004795 Int/Topo IB signature motif; other site 863638004796 malate dehydrogenase; Provisional; Region: PRK13529 863638004797 Malic enzyme, N-terminal domain; Region: malic; pfam00390 863638004798 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 863638004799 NAD(P) binding site [chemical binding]; other site 863638004800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 863638004801 Cache domain; Region: Cache_1; pfam02743 863638004802 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 863638004803 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638004804 dimer interface [polypeptide binding]; other site 863638004805 putative CheW interface [polypeptide binding]; other site 863638004806 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638004807 dimer interface [polypeptide binding]; other site 863638004808 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 863638004809 putative CheW interface [polypeptide binding]; other site 863638004810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4378 863638004811 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 863638004812 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 863638004813 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 863638004814 active site 863638004815 dimer interfaces [polypeptide binding]; other site 863638004816 catalytic residues [active] 863638004817 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 863638004818 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 863638004819 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 863638004820 Uncharacterized conserved protein [Function unknown]; Region: COG2454 863638004821 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 863638004822 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 863638004823 nucleotide binding site/active site [active] 863638004824 HIT family signature motif; other site 863638004825 catalytic residue [active] 863638004826 Transcription elongation factor Elf1 like; Region: Elf1; cl02038 863638004827 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 863638004828 MATE family multidrug exporter; Provisional; Region: PRK10189 863638004829 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 863638004830 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 863638004831 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 863638004832 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 863638004833 Walker A/P-loop; other site 863638004834 ATP binding site [chemical binding]; other site 863638004835 Q-loop/lid; other site 863638004836 ABC transporter signature motif; other site 863638004837 Walker B; other site 863638004838 D-loop; other site 863638004839 H-loop/switch region; other site 863638004840 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 863638004841 active site 863638004842 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 863638004843 active site 863638004844 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 863638004845 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 863638004846 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 863638004847 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638004848 FeS/SAM binding site; other site 863638004849 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 863638004850 dimer interface [polypeptide binding]; other site 863638004851 pyridoxal binding site [chemical binding]; other site 863638004852 ATP binding site [chemical binding]; other site 863638004853 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 863638004854 EDD domain protein, DegV family; Region: DegV; TIGR00762 863638004855 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 863638004856 Uncharacterized conserved protein [Function unknown]; Region: COG4359 863638004857 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 863638004858 Glycerol-1-phosphate_dehydrogenase and related proteins; Region: G1PDH_related; cd08549 863638004859 active site 863638004860 metal binding site [ion binding]; metal-binding site 863638004861 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit [DNA replication, recombination, and repair]; Region: GyrB; COG0187 863638004862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638004863 ATP binding site [chemical binding]; other site 863638004864 Mg2+ binding site [ion binding]; other site 863638004865 G-X-G motif; other site 863638004866 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 863638004867 anchoring element; other site 863638004868 dimer interface [polypeptide binding]; other site 863638004869 ATP binding site [chemical binding]; other site 863638004870 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 863638004871 active site 863638004872 metal binding site [ion binding]; metal-binding site 863638004873 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 863638004874 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 863638004875 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 863638004876 CAP-like domain; other site 863638004877 active site 863638004878 primary dimer interface [polypeptide binding]; other site 863638004879 DJ-1 family protein; Region: not_thiJ; TIGR01383 863638004880 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 863638004881 conserved cys residue [active] 863638004882 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 863638004883 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 863638004884 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 863638004885 biotin synthase; Provisional; Region: PRK07094 863638004886 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638004887 FeS/SAM binding site; other site 863638004888 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 863638004889 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 863638004890 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 863638004891 AP (apurinic/apyrimidinic) site pocket; other site 863638004892 DNA interaction; other site 863638004893 Metal-binding active site; metal-binding site 863638004894 Uncharacterized conserved protein [Function unknown]; Region: COG1633 863638004895 Manganese catalase-like protein, ferritin-like diiron-binding domain; Region: Mn_catalase_like; cd07908 863638004896 dinuclear metal binding motif [ion binding]; other site 863638004897 flagellin; Provisional; Region: PRK12804 863638004898 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 863638004899 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 863638004900 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 863638004901 S1 domain; Region: S1_2; pfam13509 863638004902 S1 domain; Region: S1_2; pfam13509 863638004903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 863638004904 LXG domain of WXG superfamily; Region: LXG; pfam04740 863638004905 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 863638004906 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 863638004907 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 863638004908 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 863638004909 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 863638004910 Uncharacterized conserved protein [Function unknown]; Region: COG5620 863638004911 GAD-like domain; Region: GAD-like; pfam08887 863638004912 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 863638004913 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 863638004914 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 863638004915 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 863638004916 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 863638004917 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 863638004918 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 863638004919 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 863638004920 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 863638004921 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 863638004922 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 863638004923 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 863638004924 Uncharacterized conserved protein [Function unknown]; Region: COG5620 863638004925 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 863638004926 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 863638004927 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 863638004928 G1 box; other site 863638004929 GTP/Mg2+ binding site [chemical binding]; other site 863638004930 Switch I region; other site 863638004931 G2 box; other site 863638004932 Switch II region; other site 863638004933 G3 box; other site 863638004934 G4 box; other site 863638004935 G5 box; other site 863638004936 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 863638004937 Aspartase; Region: Aspartase; cd01357 863638004938 active sites [active] 863638004939 tetramer interface [polypeptide binding]; other site 863638004940 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 863638004941 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 863638004942 Ligand binding site; other site 863638004943 Putative Catalytic site; other site 863638004944 DXD motif; other site 863638004945 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 863638004946 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 863638004947 Peptidase M16C associated; Region: M16C_assoc; pfam08367 863638004948 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 863638004949 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 863638004950 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 863638004951 dimerization interface [polypeptide binding]; other site 863638004952 ATP binding site [chemical binding]; other site 863638004953 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 863638004954 dimerization interface [polypeptide binding]; other site 863638004955 ATP binding site [chemical binding]; other site 863638004956 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 863638004957 putative active site [active] 863638004958 catalytic triad [active] 863638004959 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 863638004960 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 863638004961 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 863638004962 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 863638004963 PLD-like domain; Region: PLDc_2; pfam13091 863638004964 putative active site [active] 863638004965 catalytic site [active] 863638004966 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 863638004967 nucleotide binding site [chemical binding]; other site 863638004968 Acetokinase family; Region: Acetate_kinase; cl17229 863638004969 Ribosomal protein L7/L12 [Translation, ribosomal structure and biogenesis]; Region: RplL; COG0222 863638004970 L11 interface [polypeptide binding]; other site 863638004971 putative EF-Tu interaction site [polypeptide binding]; other site 863638004972 putative EF-G interaction site [polypeptide binding]; other site 863638004973 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 863638004974 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 863638004975 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 863638004976 homodimer interface [polypeptide binding]; other site 863638004977 active site pocket [active] 863638004978 Predicted amidohydrolase [General function prediction only]; Region: COG0388 863638004979 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 863638004980 active site 863638004981 catalytic triad [active] 863638004982 dimer interface [polypeptide binding]; other site 863638004983 Predicted membrane protein [Function unknown]; Region: COG4905 863638004984 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 863638004985 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 863638004986 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 863638004987 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638004988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638004989 Carbon starvation protein CstA; Region: CstA; pfam02554 863638004990 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 863638004991 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 863638004992 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 863638004993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638004994 active site 863638004995 phosphorylation site [posttranslational modification] 863638004996 intermolecular recognition site; other site 863638004997 dimerization interface [polypeptide binding]; other site 863638004998 LytTr DNA-binding domain; Region: LytTR; pfam04397 863638004999 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 863638005000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638005001 Walker A motif; other site 863638005002 ATP binding site [chemical binding]; other site 863638005003 Walker B motif; other site 863638005004 arginine finger; other site 863638005005 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 863638005006 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 863638005007 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 863638005008 DEAD_2; Region: DEAD_2; pfam06733 863638005009 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 863638005010 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 863638005011 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 863638005012 active site 863638005013 dimer interface [polypeptide binding]; other site 863638005014 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 863638005015 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 863638005016 active site 863638005017 FMN binding site [chemical binding]; other site 863638005018 substrate binding site [chemical binding]; other site 863638005019 3Fe-4S cluster binding site [ion binding]; other site 863638005020 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 863638005021 domain interface; other site 863638005022 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 863638005023 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 863638005024 Predicted transcriptional regulator [Transcription]; Region: COG1959 863638005025 Transcriptional regulator; Region: Rrf2; cl17282 863638005026 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 863638005027 PRC-barrel domain; Region: PRC; pfam05239 863638005028 PRC-barrel domain; Region: PRC; pfam05239 863638005029 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 863638005030 Domain of unknown function DUF20; Region: UPF0118; pfam01594 863638005031 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 863638005032 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 863638005033 motif 1; other site 863638005034 active site 863638005035 motif 2; other site 863638005036 motif 3; other site 863638005037 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 863638005038 DHHA1 domain; Region: DHHA1; pfam02272 863638005039 hypothetical protein; Provisional; Region: PRK05473 863638005040 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 863638005041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3906 863638005042 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 863638005043 metal binding site 2 [ion binding]; metal-binding site 863638005044 putative DNA binding helix; other site 863638005045 metal binding site 1 [ion binding]; metal-binding site 863638005046 dimer interface [polypeptide binding]; other site 863638005047 structural Zn2+ binding site [ion binding]; other site 863638005048 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 863638005049 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 863638005050 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 863638005051 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 863638005052 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 863638005053 G1 box; other site 863638005054 putative GEF interaction site [polypeptide binding]; other site 863638005055 GTP/Mg2+ binding site [chemical binding]; other site 863638005056 Switch I region; other site 863638005057 G2 box; other site 863638005058 G3 box; other site 863638005059 Switch II region; other site 863638005060 G4 box; other site 863638005061 G5 box; other site 863638005062 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 863638005063 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 863638005064 YceG-like family; Region: YceG; pfam02618 863638005065 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 863638005066 dimerization interface [polypeptide binding]; other site 863638005067 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 863638005068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638005069 S-adenosylmethionine binding site [chemical binding]; other site 863638005070 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 863638005071 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 863638005072 Peptidase family U32; Region: Peptidase_U32; pfam01136 863638005073 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 863638005074 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 863638005075 sporulation sigma factor SigK; Reviewed; Region: PRK05803 863638005076 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 863638005077 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 863638005078 DNA binding residues [nucleotide binding] 863638005079 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 863638005080 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 863638005081 Walker A motif; other site 863638005082 ATP binding site [chemical binding]; other site 863638005083 Walker B motif; other site 863638005084 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 863638005085 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 863638005086 DXD motif; other site 863638005087 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 863638005088 Cell division protein FtsA; Region: FtsA; smart00842 863638005089 Cell division protein FtsA; Region: FtsA; pfam14450 863638005090 cell division protein FtsZ; Validated; Region: PRK09330 863638005091 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 863638005092 nucleotide binding site [chemical binding]; other site 863638005093 SulA interaction site; other site 863638005094 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 863638005095 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 863638005096 sporulation sigma factor SigE; Reviewed; Region: PRK08301 863638005097 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 863638005098 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 863638005099 DNA binding residues [nucleotide binding] 863638005100 sporulation sigma factor SigG; Reviewed; Region: PRK08215 863638005101 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 863638005102 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 863638005103 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 863638005104 DNA binding residues [nucleotide binding] 863638005105 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 863638005106 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 863638005107 ATP cone domain; Region: ATP-cone; pfam03477 863638005108 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 863638005109 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 863638005110 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638005111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638005112 active site 863638005113 phosphorylation site [posttranslational modification] 863638005114 intermolecular recognition site; other site 863638005115 dimerization interface [polypeptide binding]; other site 863638005116 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638005117 DNA binding site [nucleotide binding] 863638005118 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638005119 dimerization interface [polypeptide binding]; other site 863638005120 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 863638005121 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 863638005122 putative active site [active] 863638005123 heme pocket [chemical binding]; other site 863638005124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638005125 dimer interface [polypeptide binding]; other site 863638005126 phosphorylation site [posttranslational modification] 863638005127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638005128 ATP binding site [chemical binding]; other site 863638005129 Mg2+ binding site [ion binding]; other site 863638005130 G-X-G motif; other site 863638005131 Cache domain; Region: Cache_1; pfam02743 863638005132 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638005133 putative CheW interface [polypeptide binding]; other site 863638005134 PBP superfamily domain; Region: PBP_like_2; cl17296 863638005135 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 863638005136 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 863638005137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638005138 dimer interface [polypeptide binding]; other site 863638005139 conserved gate region; other site 863638005140 putative PBP binding loops; other site 863638005141 ABC-ATPase subunit interface; other site 863638005142 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 863638005143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638005144 dimer interface [polypeptide binding]; other site 863638005145 conserved gate region; other site 863638005146 putative PBP binding loops; other site 863638005147 ABC-ATPase subunit interface; other site 863638005148 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 863638005149 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 863638005150 Walker A/P-loop; other site 863638005151 ATP binding site [chemical binding]; other site 863638005152 Q-loop/lid; other site 863638005153 ABC transporter signature motif; other site 863638005154 Walker B; other site 863638005155 D-loop; other site 863638005156 H-loop/switch region; other site 863638005157 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 863638005158 PhoU domain; Region: PhoU; pfam01895 863638005159 PhoU domain; Region: PhoU; pfam01895 863638005160 Fe-S oxidoreductase, related to NifB/MoaA family [Energy production and conversion]; Region: COG1625 863638005161 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 863638005162 Protein of unknown function (DUF512); Region: DUF512; pfam04459 863638005163 GTP-binding protein Der; Reviewed; Region: PRK00093 863638005164 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 863638005165 G1 box; other site 863638005166 GTP/Mg2+ binding site [chemical binding]; other site 863638005167 Switch I region; other site 863638005168 G2 box; other site 863638005169 Switch II region; other site 863638005170 G3 box; other site 863638005171 G4 box; other site 863638005172 G5 box; other site 863638005173 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 863638005174 G1 box; other site 863638005175 GTP/Mg2+ binding site [chemical binding]; other site 863638005176 Switch I region; other site 863638005177 G2 box; other site 863638005178 G3 box; other site 863638005179 Switch II region; other site 863638005180 G4 box; other site 863638005181 G5 box; other site 863638005182 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 863638005183 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 863638005184 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 863638005185 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 863638005186 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 863638005187 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 863638005188 active site 863638005189 homotetramer interface [polypeptide binding]; other site 863638005190 homodimer interface [polypeptide binding]; other site 863638005191 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 863638005192 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 863638005193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638005194 homodimer interface [polypeptide binding]; other site 863638005195 catalytic residue [active] 863638005196 hypothetical protein; Provisional; Region: PRK11820 863638005197 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 863638005198 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 863638005199 hypothetical protein; Provisional; Region: PRK04323 863638005200 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 863638005201 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 863638005202 catalytic site [active] 863638005203 G-X2-G-X-G-K; other site 863638005204 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 863638005205 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 863638005206 Flavoprotein; Region: Flavoprotein; pfam02441 863638005207 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 863638005208 primosome assembly protein PriA; Validated; Region: PRK05580 863638005209 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 863638005210 ATP binding site [chemical binding]; other site 863638005211 putative Mg++ binding site [ion binding]; other site 863638005212 helicase superfamily c-terminal domain; Region: HELICc; smart00490 863638005213 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 863638005214 active site 863638005215 catalytic residues [active] 863638005216 metal binding site [ion binding]; metal-binding site 863638005217 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 863638005218 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 863638005219 putative active site [active] 863638005220 substrate binding site [chemical binding]; other site 863638005221 putative cosubstrate binding site; other site 863638005222 catalytic site [active] 863638005223 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 863638005224 substrate binding site [chemical binding]; other site 863638005225 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 863638005226 16S rRNA methyltransferase B; Provisional; Region: PRK14902 863638005227 NusB family; Region: NusB; pfam01029 863638005228 putative RNA binding site [nucleotide binding]; other site 863638005229 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 863638005230 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 863638005231 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638005232 FeS/SAM binding site; other site 863638005233 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 863638005234 Protein phosphatase 2C; Region: PP2C; pfam00481 863638005235 active site 863638005236 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 863638005237 Catalytic domain of Protein Kinases; Region: PKc; cd00180 863638005238 active site 863638005239 ATP binding site [chemical binding]; other site 863638005240 substrate binding site [chemical binding]; other site 863638005241 activation loop (A-loop); other site 863638005242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 863638005243 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 863638005244 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 863638005245 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 863638005246 GTPase RsgA; Reviewed; Region: PRK00098 863638005247 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 863638005248 RNA binding site [nucleotide binding]; other site 863638005249 homodimer interface [polypeptide binding]; other site 863638005250 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 863638005251 GTPase/Zn-binding domain interface [polypeptide binding]; other site 863638005252 GTP/Mg2+ binding site [chemical binding]; other site 863638005253 G4 box; other site 863638005254 G5 box; other site 863638005255 G1 box; other site 863638005256 Switch I region; other site 863638005257 G2 box; other site 863638005258 G3 box; other site 863638005259 Switch II region; other site 863638005260 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 863638005261 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 863638005262 substrate binding site [chemical binding]; other site 863638005263 hexamer interface [polypeptide binding]; other site 863638005264 metal binding site [ion binding]; metal-binding site 863638005265 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 863638005266 Thiamine pyrophosphokinase; Region: TPK; cd07995 863638005267 active site 863638005268 dimerization interface [polypeptide binding]; other site 863638005269 thiamine binding site [chemical binding]; other site 863638005270 ribosomal protein L28; Region: L28; TIGR00009 863638005271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 863638005272 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 863638005273 DAK2 domain; Region: Dak2; pfam02734 863638005274 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 863638005275 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 863638005276 ssDNA binding site; other site 863638005277 generic binding surface II; other site 863638005278 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 863638005279 ATP binding site [chemical binding]; other site 863638005280 putative Mg++ binding site [ion binding]; other site 863638005281 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 863638005282 nucleotide binding region [chemical binding]; other site 863638005283 ATP-binding site [chemical binding]; other site 863638005284 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 863638005285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638005286 S-adenosylmethionine binding site [chemical binding]; other site 863638005287 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 863638005288 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 863638005289 active site 863638005290 (T/H)XGH motif; other site 863638005291 phosphodiesterase; Provisional; Region: PRK12704 863638005292 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 863638005293 hypothetical protein; Provisional; Region: PRK13670 863638005294 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 863638005295 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 863638005296 propionate/acetate kinase; Provisional; Region: PRK12379 863638005297 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 863638005298 nucleotide binding site [chemical binding]; other site 863638005299 butyrate kinase; Provisional; Region: PRK03011 863638005300 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 863638005301 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 863638005302 putative phosphate acyltransferase; Provisional; Region: PRK05331 863638005303 acyl carrier protein; Provisional; Region: acpP; PRK00982 863638005304 ribonuclease III; Reviewed; Region: rnc; PRK00102 863638005305 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 863638005306 dimerization interface [polypeptide binding]; other site 863638005307 active site 863638005308 metal binding site [ion binding]; metal-binding site 863638005309 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 863638005310 dsRNA binding site [nucleotide binding]; other site 863638005311 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 863638005312 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638005313 FeS/SAM binding site; other site 863638005314 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 863638005315 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 863638005316 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 863638005317 Walker A/P-loop; other site 863638005318 ATP binding site [chemical binding]; other site 863638005319 Q-loop/lid; other site 863638005320 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 863638005321 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 863638005322 ABC transporter signature motif; other site 863638005323 Walker B; other site 863638005324 D-loop; other site 863638005325 H-loop/switch region; other site 863638005326 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 863638005327 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 863638005328 P loop; other site 863638005329 GTP binding site [chemical binding]; other site 863638005330 putative DNA-binding protein; Validated; Region: PRK00118 863638005331 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 863638005332 signal recognition particle protein; Provisional; Region: PRK10867 863638005333 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 863638005334 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 863638005335 P loop; other site 863638005336 GTP binding site [chemical binding]; other site 863638005337 Signal peptide binding domain; Region: SRP_SPB; pfam02978 863638005338 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 863638005339 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 863638005340 hypothetical protein; Provisional; Region: PRK00468 863638005341 G-X-X-G motif; other site 863638005342 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 863638005343 RimM N-terminal domain; Region: RimM; pfam01782 863638005344 PRC-barrel domain; Region: PRC; pfam05239 863638005345 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 863638005346 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 863638005347 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 863638005348 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 863638005349 Catalytic site [active] 863638005350 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 863638005351 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 863638005352 GTP/Mg2+ binding site [chemical binding]; other site 863638005353 G4 box; other site 863638005354 G5 box; other site 863638005355 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 863638005356 G1 box; other site 863638005357 G1 box; other site 863638005358 GTP/Mg2+ binding site [chemical binding]; other site 863638005359 Switch I region; other site 863638005360 G2 box; other site 863638005361 G2 box; other site 863638005362 Switch I region; other site 863638005363 G3 box; other site 863638005364 G3 box; other site 863638005365 Switch II region; other site 863638005366 Switch II region; other site 863638005367 G4 box; other site 863638005368 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 863638005369 RNA/DNA hybrid binding site [nucleotide binding]; other site 863638005370 active site 863638005371 hypothetical protein; Reviewed; Region: PRK12497 863638005372 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 863638005373 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 863638005374 catalytic triad [active] 863638005375 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 863638005376 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 863638005377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638005378 Walker A motif; other site 863638005379 ATP binding site [chemical binding]; other site 863638005380 Walker B motif; other site 863638005381 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 863638005382 RNA polymerase factor sigma-70; Validated; Region: PRK06811 863638005383 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 863638005384 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 863638005385 DNA binding residues [nucleotide binding] 863638005386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 863638005387 RNA polymerase sigma-I factor; Region: spore_sigI; TIGR02895 863638005388 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 863638005389 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 863638005390 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 863638005391 active site 863638005392 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 863638005393 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 863638005394 substrate binding [chemical binding]; other site 863638005395 active site 863638005396 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 863638005397 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 863638005398 active site 863638005399 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 863638005400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638005401 motif II; other site 863638005402 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 863638005403 nudix motif; other site 863638005404 nudix motif; other site 863638005405 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 863638005406 Isochorismatase family; Region: Isochorismatase; pfam00857 863638005407 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 863638005408 catalytic triad [active] 863638005409 conserved cis-peptide bond; other site 863638005410 ABC-2 type transporter; Region: ABC2_membrane; cl17235 863638005411 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 863638005412 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 863638005413 active site 863638005414 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 863638005415 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 863638005416 active site 863638005417 (T/H)XGH motif; other site 863638005418 NAD synthetase; Reviewed; Region: nadE; PRK02628 863638005419 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 863638005420 multimer interface [polypeptide binding]; other site 863638005421 active site 863638005422 catalytic triad [active] 863638005423 protein interface 1 [polypeptide binding]; other site 863638005424 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 863638005425 homodimer interface [polypeptide binding]; other site 863638005426 NAD binding pocket [chemical binding]; other site 863638005427 ATP binding pocket [chemical binding]; other site 863638005428 Mg binding site [ion binding]; other site 863638005429 active-site loop [active] 863638005430 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 863638005431 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 863638005432 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 863638005433 DNA protecting protein DprA; Region: dprA; TIGR00732 863638005434 DNA topoisomerase I; Validated; Region: PRK05582 863638005435 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 863638005436 active site 863638005437 interdomain interaction site; other site 863638005438 putative metal-binding site [ion binding]; other site 863638005439 nucleotide binding site [chemical binding]; other site 863638005440 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 863638005441 domain I; other site 863638005442 DNA binding groove [nucleotide binding] 863638005443 phosphate binding site [ion binding]; other site 863638005444 domain II; other site 863638005445 domain III; other site 863638005446 nucleotide binding site [chemical binding]; other site 863638005447 catalytic site [active] 863638005448 domain IV; other site 863638005449 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 863638005450 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 863638005451 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 863638005452 transcriptional repressor CodY; Validated; Region: PRK04158 863638005453 CodY GAF-like domain; Region: CodY; pfam06018 863638005454 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 863638005455 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 863638005456 rRNA interaction site [nucleotide binding]; other site 863638005457 S8 interaction site; other site 863638005458 putative laminin-1 binding site; other site 863638005459 elongation factor Ts; Provisional; Region: tsf; PRK09377 863638005460 UBA/TS-N domain; Region: UBA; pfam00627 863638005461 Elongation factor TS; Region: EF_TS; pfam00889 863638005462 Elongation factor TS; Region: EF_TS; pfam00889 863638005463 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 863638005464 putative nucleotide binding site [chemical binding]; other site 863638005465 uridine monophosphate binding site [chemical binding]; other site 863638005466 homohexameric interface [polypeptide binding]; other site 863638005467 ribosome recycling factor; Reviewed; Region: frr; PRK00083 863638005468 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 863638005469 hinge region; other site 863638005470 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 863638005471 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 863638005472 catalytic residue [active] 863638005473 putative FPP diphosphate binding site; other site 863638005474 putative FPP binding hydrophobic cleft; other site 863638005475 dimer interface [polypeptide binding]; other site 863638005476 putative IPP diphosphate binding site; other site 863638005477 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 863638005478 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 863638005479 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 863638005480 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 863638005481 Catalytic site [active] 863638005482 Domain of unknown function DUF20; Region: UPF0118; pfam01594 863638005483 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 863638005484 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 863638005485 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 863638005486 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 863638005487 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 863638005488 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 863638005489 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 863638005490 active site 863638005491 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 863638005492 protein binding site [polypeptide binding]; other site 863638005493 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 863638005494 putative substrate binding region [chemical binding]; other site 863638005495 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 863638005496 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 863638005497 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 863638005498 ribosome maturation protein RimP; Reviewed; Region: PRK00092 863638005499 Sm and related proteins; Region: Sm_like; cl00259 863638005500 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 863638005501 putative oligomer interface [polypeptide binding]; other site 863638005502 putative RNA binding site [nucleotide binding]; other site 863638005503 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 863638005504 NusA N-terminal domain; Region: NusA_N; pfam08529 863638005505 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 863638005506 RNA binding site [nucleotide binding]; other site 863638005507 homodimer interface [polypeptide binding]; other site 863638005508 NusA-like KH domain; Region: KH_5; pfam13184 863638005509 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 863638005510 G-X-X-G motif; other site 863638005511 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 863638005512 putative RNA binding cleft [nucleotide binding]; other site 863638005513 ribosomal protein L7Ae family protein; Provisional; Region: PRK05583 863638005514 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 863638005515 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 863638005516 translation initiation factor IF-2; Region: IF-2; TIGR00487 863638005517 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 863638005518 G1 box; other site 863638005519 putative GEF interaction site [polypeptide binding]; other site 863638005520 GTP/Mg2+ binding site [chemical binding]; other site 863638005521 Switch I region; other site 863638005522 G2 box; other site 863638005523 G3 box; other site 863638005524 Switch II region; other site 863638005525 G4 box; other site 863638005526 G5 box; other site 863638005527 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 863638005528 Translation-initiation factor 2; Region: IF-2; pfam11987 863638005529 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 863638005530 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 863638005531 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 863638005532 DHH family; Region: DHH; pfam01368 863638005533 DHHA1 domain; Region: DHHA1; pfam02272 863638005534 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 863638005535 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 863638005536 RNA binding site [nucleotide binding]; other site 863638005537 active site 863638005538 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 863638005539 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 863638005540 active site 863638005541 Riboflavin kinase; Region: Flavokinase; smart00904 863638005542 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 863638005543 16S/18S rRNA binding site [nucleotide binding]; other site 863638005544 S13e-L30e interaction site [polypeptide binding]; other site 863638005545 25S rRNA binding site [nucleotide binding]; other site 863638005546 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 863638005547 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 863638005548 RNase E interface [polypeptide binding]; other site 863638005549 trimer interface [polypeptide binding]; other site 863638005550 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 863638005551 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 863638005552 RNase E interface [polypeptide binding]; other site 863638005553 trimer interface [polypeptide binding]; other site 863638005554 active site 863638005555 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 863638005556 putative nucleic acid binding region [nucleotide binding]; other site 863638005557 G-X-X-G motif; other site 863638005558 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 863638005559 RNA binding site [nucleotide binding]; other site 863638005560 domain interface; other site 863638005561 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 863638005562 aspartate kinase I; Reviewed; Region: PRK08210 863638005563 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 863638005564 nucleotide binding site [chemical binding]; other site 863638005565 substrate binding site [chemical binding]; other site 863638005566 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 863638005567 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 863638005568 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 863638005569 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 863638005570 active site 863638005571 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 863638005572 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 863638005573 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 863638005574 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 863638005575 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 863638005576 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 863638005577 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638005578 FeS/SAM binding site; other site 863638005579 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 863638005580 recombinase A; Provisional; Region: recA; PRK09354 863638005581 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 863638005582 hexamer interface [polypeptide binding]; other site 863638005583 Walker A motif; other site 863638005584 ATP binding site [chemical binding]; other site 863638005585 Walker B motif; other site 863638005586 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 863638005587 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 863638005588 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638005589 Zn2+ binding site [ion binding]; other site 863638005590 Mg2+ binding site [ion binding]; other site 863638005591 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 863638005592 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 863638005593 aspartate aminotransferase; Provisional; Region: PRK05764 863638005594 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 863638005595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638005596 homodimer interface [polypeptide binding]; other site 863638005597 catalytic residue [active] 863638005598 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 863638005599 regulatory protein interface [polypeptide binding]; other site 863638005600 active site 863638005601 regulatory phosphorylation site [posttranslational modification]; other site 863638005602 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 863638005603 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 863638005604 tetramer interface [polypeptide binding]; other site 863638005605 active site 863638005606 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 863638005607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 863638005608 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 863638005609 Uncharacterized conserved protein [Function unknown]; Region: COG2127 863638005610 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 863638005611 Clp amino terminal domain; Region: Clp_N; pfam02861 863638005612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638005613 Walker A motif; other site 863638005614 ATP binding site [chemical binding]; other site 863638005615 Walker B motif; other site 863638005616 arginine finger; other site 863638005617 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638005618 Walker A motif; other site 863638005619 ATP binding site [chemical binding]; other site 863638005620 Walker B motif; other site 863638005621 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 863638005622 Homoserine O-succinyltransferase; Region: HTS; pfam04204 863638005623 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 863638005624 proposed active site lysine [active] 863638005625 conserved cys residue [active] 863638005626 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 863638005627 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 863638005628 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 863638005629 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 863638005630 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 863638005631 active site 863638005632 DNA binding site [nucleotide binding] 863638005633 Int/Topo IB signature motif; other site 863638005634 LexA repressor; Validated; Region: PRK00215 863638005635 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 863638005636 putative DNA binding site [nucleotide binding]; other site 863638005637 putative Zn2+ binding site [ion binding]; other site 863638005638 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 863638005639 Catalytic site [active] 863638005640 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 863638005641 Aluminium resistance protein; Region: Alum_res; pfam06838 863638005642 bacterial Hfq-like; Region: Hfq; cd01716 863638005643 hexamer interface [polypeptide binding]; other site 863638005644 Sm1 motif; other site 863638005645 RNA binding site [nucleotide binding]; other site 863638005646 Sm2 motif; other site 863638005647 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 863638005648 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 863638005649 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 863638005650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638005651 ATP binding site [chemical binding]; other site 863638005652 Mg2+ binding site [ion binding]; other site 863638005653 G-X-G motif; other site 863638005654 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 863638005655 ATP binding site [chemical binding]; other site 863638005656 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 863638005657 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 863638005658 MutS domain I; Region: MutS_I; pfam01624 863638005659 MutS domain II; Region: MutS_II; pfam05188 863638005660 MutS domain III; Region: MutS_III; pfam05192 863638005661 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 863638005662 Walker A/P-loop; other site 863638005663 ATP binding site [chemical binding]; other site 863638005664 Q-loop/lid; other site 863638005665 ABC transporter signature motif; other site 863638005666 Walker B; other site 863638005667 D-loop; other site 863638005668 H-loop/switch region; other site 863638005669 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 863638005670 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 863638005671 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638005672 FeS/SAM binding site; other site 863638005673 TRAM domain; Region: TRAM; pfam01938 863638005674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638005675 Coenzyme A binding pocket [chemical binding]; other site 863638005676 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 863638005677 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 863638005678 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 863638005679 active site 863638005680 ATP binding site [chemical binding]; other site 863638005681 substrate binding site [chemical binding]; other site 863638005682 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 863638005683 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 863638005684 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638005685 non-specific DNA binding site [nucleotide binding]; other site 863638005686 salt bridge; other site 863638005687 sequence-specific DNA binding site [nucleotide binding]; other site 863638005688 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 863638005689 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 863638005690 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 863638005691 ligand binding site [chemical binding]; other site 863638005692 flagellar motor protein MotA; Validated; Region: PRK08124 863638005693 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 863638005694 LytB protein; Region: LYTB; cl00507 863638005695 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 863638005696 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 863638005697 RNA binding site [nucleotide binding]; other site 863638005698 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 863638005699 RNA binding site [nucleotide binding]; other site 863638005700 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 863638005701 RNA binding site [nucleotide binding]; other site 863638005702 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 863638005703 RNA binding site [nucleotide binding]; other site 863638005704 cytidylate kinase; Provisional; Region: cmk; PRK00023 863638005705 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 863638005706 CMP-binding site; other site 863638005707 The sites determining sugar specificity; other site 863638005708 Predicted flavoproteins [General function prediction only]; Region: COG2081 863638005709 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 863638005710 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 863638005711 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 863638005712 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 863638005713 putative active site [active] 863638005714 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 863638005715 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 863638005716 RNA binding surface [nucleotide binding]; other site 863638005717 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 863638005718 active site 863638005719 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 863638005720 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 863638005721 oligomer interface [polypeptide binding]; other site 863638005722 metal binding site [ion binding]; metal-binding site 863638005723 metal binding site [ion binding]; metal-binding site 863638005724 Cl binding site [ion binding]; other site 863638005725 aspartate ring; other site 863638005726 basic sphincter; other site 863638005727 putative hydrophobic gate; other site 863638005728 periplasmic entrance; other site 863638005729 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 863638005730 dimer interface [polypeptide binding]; other site 863638005731 ADP-ribose binding site [chemical binding]; other site 863638005732 active site 863638005733 nudix motif; other site 863638005734 metal binding site [ion binding]; metal-binding site 863638005735 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 863638005736 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 863638005737 RNA/DNA hybrid binding site [nucleotide binding]; other site 863638005738 active site 863638005739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 863638005740 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 863638005741 metal ion-dependent adhesion site (MIDAS); other site 863638005742 MoxR-like ATPases [General function prediction only]; Region: COG0714 863638005743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638005744 Walker A motif; other site 863638005745 ATP binding site [chemical binding]; other site 863638005746 Walker B motif; other site 863638005747 hypothetical protein; Provisional; Region: PRK05802 863638005748 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 863638005749 FAD binding pocket [chemical binding]; other site 863638005750 FAD binding motif [chemical binding]; other site 863638005751 phosphate binding motif [ion binding]; other site 863638005752 beta-alpha-beta structure motif; other site 863638005753 NAD binding pocket [chemical binding]; other site 863638005754 Iron coordination center [ion binding]; other site 863638005755 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 863638005756 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 863638005757 catalytic residues [active] 863638005758 catalytic nucleophile [active] 863638005759 Presynaptic Site I dimer interface [polypeptide binding]; other site 863638005760 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 863638005761 Synaptic Flat tetramer interface [polypeptide binding]; other site 863638005762 Synaptic Site I dimer interface [polypeptide binding]; other site 863638005763 DNA binding site [nucleotide binding] 863638005764 Recombinase; Region: Recombinase; pfam07508 863638005765 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 863638005766 Glucose inhibited division protein A; Region: GIDA; pfam01134 863638005767 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 863638005768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638005769 non-specific DNA binding site [nucleotide binding]; other site 863638005770 salt bridge; other site 863638005771 sequence-specific DNA binding site [nucleotide binding]; other site 863638005772 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 863638005773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638005774 non-specific DNA binding site [nucleotide binding]; other site 863638005775 salt bridge; other site 863638005776 sequence-specific DNA binding site [nucleotide binding]; other site 863638005777 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 863638005778 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 863638005779 Plasmid rolling circle replication initiator protein and truncated derivatives [DNA replication, recombination, and repair]; Region: COG5655 863638005780 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 863638005781 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 863638005782 active site 863638005783 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 863638005784 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 863638005785 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 863638005786 Haemolysin XhlA; Region: XhlA; pfam10779 863638005787 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 863638005788 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 863638005789 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 863638005790 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 863638005791 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 863638005792 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 863638005793 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 863638005794 N-acetyl-D-glucosamine binding site [chemical binding]; other site 863638005795 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 863638005796 Bacterial Ig-like domain; Region: Big_5; pfam13205 863638005797 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 863638005798 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 863638005799 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 863638005800 oligomerization interface [polypeptide binding]; other site 863638005801 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 863638005802 Phage capsid family; Region: Phage_capsid; pfam05065 863638005803 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 863638005804 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 863638005805 oligomer interface [polypeptide binding]; other site 863638005806 active site residues [active] 863638005807 Phage-related protein [Function unknown]; Region: COG4695 863638005808 Phage portal protein; Region: Phage_portal; pfam04860 863638005809 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 863638005810 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 863638005811 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 863638005812 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 863638005813 active site 863638005814 Mu-like prophage protein Com [General function prediction only]; Region: Com; COG4416 863638005815 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 863638005816 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 863638005817 catalytic site [active] 863638005818 putative active site [active] 863638005819 putative substrate binding site [chemical binding]; other site 863638005820 Helix-turn-helix domain; Region: HTH_17; pfam12728 863638005821 DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger) [Transcription]; Region: RPC10; COG1996 863638005822 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 863638005823 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 863638005824 dimer interface [polypeptide binding]; other site 863638005825 ssDNA binding site [nucleotide binding]; other site 863638005826 tetramer (dimer of dimers) interface [polypeptide binding]; other site 863638005827 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 863638005828 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u5; cd11542 863638005829 metal binding site [ion binding]; metal-binding site 863638005830 hypothetical protein; Validated; Region: PRK08116 863638005831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638005832 Walker A motif; other site 863638005833 ATP binding site [chemical binding]; other site 863638005834 Walker B motif; other site 863638005835 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 863638005836 Coronavirus S2 glycoprotein; Region: Corona_S2; pfam01601 863638005837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4712 863638005838 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 863638005839 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 863638005840 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 863638005841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4306 863638005842 Phage anti-repressor protein [Transcription]; Region: COG3561 863638005843 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638005844 non-specific DNA binding site [nucleotide binding]; other site 863638005845 salt bridge; other site 863638005846 sequence-specific DNA binding site [nucleotide binding]; other site 863638005847 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 863638005848 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638005849 non-specific DNA binding site [nucleotide binding]; other site 863638005850 salt bridge; other site 863638005851 sequence-specific DNA binding site [nucleotide binding]; other site 863638005852 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638005853 non-specific DNA binding site [nucleotide binding]; other site 863638005854 salt bridge; other site 863638005855 sequence-specific DNA binding site [nucleotide binding]; other site 863638005856 Predicted transcriptional regulator [Transcription]; Region: COG3655 863638005857 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 863638005858 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 863638005859 catalytic residues [active] 863638005860 catalytic nucleophile [active] 863638005861 Presynaptic Site I dimer interface [polypeptide binding]; other site 863638005862 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 863638005863 Synaptic Flat tetramer interface [polypeptide binding]; other site 863638005864 Synaptic Site I dimer interface [polypeptide binding]; other site 863638005865 DNA binding site [nucleotide binding] 863638005866 Recombinase; Region: Recombinase; pfam07508 863638005867 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 863638005868 Glucose inhibited division protein A; Region: GIDA; pfam01134 863638005869 Membrane protein of unknown function; Region: DUF360; pfam04020 863638005870 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 863638005871 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 863638005872 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 863638005873 catalytic residues [active] 863638005874 catalytic nucleophile [active] 863638005875 Recombinase; Region: Recombinase; pfam07508 863638005876 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 863638005877 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 863638005878 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 863638005879 active site 863638005880 catalytic tetrad [active] 863638005881 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 863638005882 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 863638005883 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 863638005884 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 863638005885 putative active site [active] 863638005886 putative metal binding site [ion binding]; other site 863638005887 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 863638005888 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 863638005889 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 863638005890 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 863638005891 active site 863638005892 metal binding site [ion binding]; metal-binding site 863638005893 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 863638005894 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 863638005895 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 863638005896 transcription elongation factor GreA; Region: greA; TIGR01462 863638005897 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 863638005898 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 863638005899 pectinesterase/pectinesterase inhibitor; Region: PLN02301 863638005900 Right handed beta helix region; Region: Beta_helix; pfam13229 863638005901 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 863638005902 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 863638005903 Walker A motif; other site 863638005904 ATP binding site [chemical binding]; other site 863638005905 Walker B motif; other site 863638005906 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 863638005907 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 863638005908 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 863638005909 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 863638005910 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 863638005911 Walker A motif; other site 863638005912 ATP binding site [chemical binding]; other site 863638005913 Walker B motif; other site 863638005914 AAA domain; Region: AAA_31; pfam13614 863638005915 EamA-like transporter family; Region: EamA; pfam00892 863638005916 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 863638005917 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 863638005918 putative ligand binding residues [chemical binding]; other site 863638005919 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 863638005920 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 863638005921 Walker A/P-loop; other site 863638005922 ATP binding site [chemical binding]; other site 863638005923 Q-loop/lid; other site 863638005924 ABC transporter signature motif; other site 863638005925 Walker B; other site 863638005926 D-loop; other site 863638005927 H-loop/switch region; other site 863638005928 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 863638005929 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 863638005930 ABC-ATPase subunit interface; other site 863638005931 dimer interface [polypeptide binding]; other site 863638005932 putative PBP binding regions; other site 863638005933 MOSC domain; Region: MOSC; pfam03473 863638005934 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 863638005935 trimer interface [polypeptide binding]; other site 863638005936 dimer interface [polypeptide binding]; other site 863638005937 putative active site [active] 863638005938 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 863638005939 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638005940 FeS/SAM binding site; other site 863638005941 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 863638005942 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 863638005943 MPT binding site; other site 863638005944 trimer interface [polypeptide binding]; other site 863638005945 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 863638005946 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 863638005947 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638005948 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 863638005949 Walker A/P-loop; other site 863638005950 ATP binding site [chemical binding]; other site 863638005951 Q-loop/lid; other site 863638005952 ABC transporter signature motif; other site 863638005953 Walker B; other site 863638005954 D-loop; other site 863638005955 H-loop/switch region; other site 863638005956 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 863638005957 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 863638005958 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 863638005959 dimer interface [polypeptide binding]; other site 863638005960 PYR/PP interface [polypeptide binding]; other site 863638005961 TPP binding site [chemical binding]; other site 863638005962 substrate binding site [chemical binding]; other site 863638005963 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 863638005964 TPP-binding site; other site 863638005965 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 863638005966 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 863638005967 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 863638005968 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 863638005969 FtsX-like permease family; Region: FtsX; pfam02687 863638005970 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 863638005971 FtsX-like permease family; Region: FtsX; pfam02687 863638005972 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 863638005973 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 863638005974 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 863638005975 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 863638005976 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 863638005977 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 863638005978 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 863638005979 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 863638005980 dimer interface [polypeptide binding]; other site 863638005981 active site 863638005982 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 863638005983 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 863638005984 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 863638005985 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 863638005986 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 863638005987 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638005988 FeS/SAM binding site; other site 863638005989 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 863638005990 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 863638005991 dimer interface [polypeptide binding]; other site 863638005992 active site 863638005993 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 863638005994 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 863638005995 substrate binding site [chemical binding]; other site 863638005996 oxyanion hole (OAH) forming residues; other site 863638005997 trimer interface [polypeptide binding]; other site 863638005998 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 863638005999 active site 863638006000 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 863638006001 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 863638006002 substrate binding site [chemical binding]; other site 863638006003 oxyanion hole (OAH) forming residues; other site 863638006004 trimer interface [polypeptide binding]; other site 863638006005 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 863638006006 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 863638006007 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 863638006008 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 863638006009 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 863638006010 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 863638006011 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 863638006012 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 863638006013 dimer interface [polypeptide binding]; other site 863638006014 putative functional site; other site 863638006015 putative MPT binding site; other site 863638006016 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 863638006017 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 863638006018 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 863638006019 dimer interface [polypeptide binding]; other site 863638006020 putative functional site; other site 863638006021 putative MPT binding site; other site 863638006022 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 863638006023 MPT binding site; other site 863638006024 trimer interface [polypeptide binding]; other site 863638006025 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 863638006026 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 863638006027 hydrophobic ligand binding site; other site 863638006028 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 863638006029 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 863638006030 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 863638006031 Preprotein translocase subunit; Region: YajC; cl00806 863638006032 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 863638006033 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 863638006034 Walker A/P-loop; other site 863638006035 ATP binding site [chemical binding]; other site 863638006036 Q-loop/lid; other site 863638006037 ABC transporter signature motif; other site 863638006038 Walker B; other site 863638006039 D-loop; other site 863638006040 H-loop/switch region; other site 863638006041 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 863638006042 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 863638006043 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 863638006044 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 863638006045 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 863638006046 putative active site [active] 863638006047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 863638006048 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 863638006049 AAA-like domain; Region: AAA_10; pfam12846 863638006050 PrgI family protein; Region: PrgI; pfam12666 863638006051 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; Region: RpoD; COG0568 863638006052 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 863638006053 Winged helix-turn helix; Region: HTH_29; pfam13551 863638006054 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 863638006055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638006056 non-specific DNA binding site [nucleotide binding]; other site 863638006057 salt bridge; other site 863638006058 sequence-specific DNA binding site [nucleotide binding]; other site 863638006059 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 863638006060 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 863638006061 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 863638006062 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 863638006063 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 863638006064 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 863638006065 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 863638006066 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 863638006067 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 863638006068 active site 863638006069 NTP binding site [chemical binding]; other site 863638006070 metal binding triad [ion binding]; metal-binding site 863638006071 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 863638006072 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 863638006073 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 863638006074 purine nucleoside phosphorylase; Provisional; Region: PRK08202 863638006075 phosphopentomutase; Provisional; Region: PRK05362 863638006076 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 863638006077 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 863638006078 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 863638006079 active site 863638006080 Int/Topo IB signature motif; other site 863638006081 stage II sporulation protein M; Region: spo_II_M; TIGR02831 863638006082 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 863638006083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638006084 active site 863638006085 phosphorylation site [posttranslational modification] 863638006086 intermolecular recognition site; other site 863638006087 dimerization interface [polypeptide binding]; other site 863638006088 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 863638006089 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 863638006090 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 863638006091 protein binding site [polypeptide binding]; other site 863638006092 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 863638006093 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 863638006094 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 863638006095 Walker A/P-loop; other site 863638006096 ATP binding site [chemical binding]; other site 863638006097 Q-loop/lid; other site 863638006098 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 863638006099 ABC transporter signature motif; other site 863638006100 Walker B; other site 863638006101 D-loop; other site 863638006102 H-loop/switch region; other site 863638006103 arginine repressor; Provisional; Region: argR; PRK00441 863638006104 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 863638006105 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 863638006106 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 863638006107 ATP-NAD kinase; Region: NAD_kinase; pfam01513 863638006108 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 863638006109 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 863638006110 RNA binding surface [nucleotide binding]; other site 863638006111 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 863638006112 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 863638006113 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 863638006114 TPP-binding site; other site 863638006115 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 863638006116 PYR/PP interface [polypeptide binding]; other site 863638006117 dimer interface [polypeptide binding]; other site 863638006118 TPP binding site [chemical binding]; other site 863638006119 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 863638006120 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 863638006121 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 863638006122 substrate binding pocket [chemical binding]; other site 863638006123 chain length determination region; other site 863638006124 substrate-Mg2+ binding site; other site 863638006125 catalytic residues [active] 863638006126 aspartate-rich region 1; other site 863638006127 active site lid residues [active] 863638006128 aspartate-rich region 2; other site 863638006129 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 863638006130 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 863638006131 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 863638006132 generic binding surface I; other site 863638006133 generic binding surface II; other site 863638006134 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14172 863638006135 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 863638006136 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 863638006137 homodimer interface [polypeptide binding]; other site 863638006138 NADP binding site [chemical binding]; other site 863638006139 substrate binding site [chemical binding]; other site 863638006140 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 863638006141 putative RNA binding site [nucleotide binding]; other site 863638006142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 863638006143 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 863638006144 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 863638006145 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 863638006146 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 863638006147 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 863638006148 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 863638006149 stage III sporulation protein AB; Region: spore_III_AB; TIGR02833 863638006150 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 863638006151 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 863638006152 elongation factor P; Validated; Region: PRK00529 863638006153 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 863638006154 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 863638006155 RNA binding site [nucleotide binding]; other site 863638006156 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 863638006157 RNA binding site [nucleotide binding]; other site 863638006158 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 863638006159 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 863638006160 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 863638006161 active site 863638006162 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 863638006163 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 863638006164 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 863638006165 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 863638006166 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 863638006167 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 863638006168 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 863638006169 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 863638006170 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 863638006171 Walker A motif; other site 863638006172 ATP binding site [chemical binding]; other site 863638006173 Walker B motif; other site 863638006174 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638006175 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638006176 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 863638006177 trimer interface [polypeptide binding]; other site 863638006178 active site 863638006179 substrate binding site [chemical binding]; other site 863638006180 CoA binding site [chemical binding]; other site 863638006181 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 863638006182 GAF domain; Region: GAF_2; pfam13185 863638006183 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 863638006184 Domain of unknown function (DUF814); Region: DUF814; pfam05670 863638006185 potential frameshift: common BLAST hit: gi|337737329|ref|YP_004636776.1| Uracil permease UraA/PyrP 863638006186 uracil transporter; Provisional; Region: PRK10720 863638006187 uracil transporter; Provisional; Region: PRK10720 863638006188 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 863638006189 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 863638006190 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 863638006191 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 863638006192 RNA binding surface [nucleotide binding]; other site 863638006193 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 863638006194 active site 863638006195 lipoprotein signal peptidase; Provisional; Region: PRK14791 863638006196 lipoprotein signal peptidase; Provisional; Region: PRK14787 863638006197 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 863638006198 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 863638006199 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 863638006200 DivIVA protein; Region: DivIVA; pfam05103 863638006201 DivIVA domain; Region: DivI1A_domain; TIGR03544 863638006202 YGGT family; Region: YGGT; pfam02325 863638006203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 863638006204 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 863638006205 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 863638006206 catalytic residue [active] 863638006207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 863638006208 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 863638006209 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 863638006210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 863638006211 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 863638006212 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 863638006213 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 863638006214 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 863638006215 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 863638006216 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 863638006217 Mg++ binding site [ion binding]; other site 863638006218 putative catalytic motif [active] 863638006219 putative substrate binding site [chemical binding]; other site 863638006220 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 863638006221 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 863638006222 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 863638006223 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 863638006224 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 863638006225 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 863638006226 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 863638006227 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 863638006228 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 863638006229 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 863638006230 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 863638006231 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 863638006232 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 863638006233 Septum formation initiator; Region: DivIC; cl17659 863638006234 MraW methylase family; Region: Methyltransf_5; pfam01795 863638006235 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 863638006236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 863638006237 MraZ protein; Region: MraZ; pfam02381 863638006238 MraZ protein; Region: MraZ; pfam02381 863638006239 GTP-binding protein YchF; Reviewed; Region: PRK09601 863638006240 YchF GTPase; Region: YchF; cd01900 863638006241 G1 box; other site 863638006242 GTP/Mg2+ binding site [chemical binding]; other site 863638006243 Switch I region; other site 863638006244 G2 box; other site 863638006245 Switch II region; other site 863638006246 G3 box; other site 863638006247 G4 box; other site 863638006248 G5 box; other site 863638006249 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 863638006250 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 863638006251 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 863638006252 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 863638006253 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 863638006254 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 863638006255 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 863638006256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638006257 motif II; other site 863638006258 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 863638006259 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 863638006260 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 863638006261 DHHA2 domain; Region: DHHA2; pfam02833 863638006262 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 863638006263 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 863638006264 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 863638006265 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 863638006266 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 863638006267 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 863638006268 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 863638006269 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 863638006270 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 863638006271 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 863638006272 DNA binding residues [nucleotide binding] 863638006273 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 863638006274 Flagellar protein YcgR; Region: YcgR_2; pfam12945 863638006275 PilZ domain; Region: PilZ; pfam07238 863638006276 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 863638006277 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 863638006278 P-loop; other site 863638006279 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 863638006280 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 863638006281 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 863638006282 FHIPEP family; Region: FHIPEP; pfam00771 863638006283 bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772 863638006284 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 863638006285 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 863638006286 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 863638006287 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 863638006288 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 863638006289 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 863638006290 Flagellar protein (FlbD); Region: FlbD; pfam06289 863638006291 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 863638006292 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 863638006293 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 863638006294 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 863638006295 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 863638006296 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 863638006297 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 863638006298 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 863638006299 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 863638006300 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 863638006301 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 863638006302 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 863638006303 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 863638006304 Walker A motif/ATP binding site; other site 863638006305 Walker B motif; other site 863638006306 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 863638006307 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 863638006308 FliG C-terminal domain; Region: FliG_C; pfam01706 863638006309 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 863638006310 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 863638006311 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 863638006312 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 863638006313 flagellar basal-body rod protein FlgC; Region: FlgC; TIGR01395 863638006314 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 863638006315 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623 863638006316 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 863638006317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 863638006318 NAD(P) binding site [chemical binding]; other site 863638006319 active site 863638006320 flagellin; Provisional; Region: PRK12804 863638006321 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 863638006322 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 863638006323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 863638006324 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 863638006325 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 863638006326 UDP-galactopyranose mutase; Region: GLF; pfam03275 863638006327 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 863638006328 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 863638006329 Probable Catalytic site; other site 863638006330 metal-binding site 863638006331 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 863638006332 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 863638006333 Probable Catalytic site; other site 863638006334 metal-binding site 863638006335 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 863638006336 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 863638006337 active site 863638006338 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 863638006339 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 863638006340 active site 863638006341 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 863638006342 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 863638006343 active site 863638006344 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 863638006345 active site 863638006346 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 863638006347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 863638006348 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 863638006349 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 863638006350 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 863638006351 inhibitor-cofactor binding pocket; inhibition site 863638006352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638006353 catalytic residue [active] 863638006354 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 863638006355 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 863638006356 NADP binding site [chemical binding]; other site 863638006357 active site 863638006358 putative substrate binding site [chemical binding]; other site 863638006359 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 863638006360 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 863638006361 NADP-binding site; other site 863638006362 homotetramer interface [polypeptide binding]; other site 863638006363 substrate binding site [chemical binding]; other site 863638006364 homodimer interface [polypeptide binding]; other site 863638006365 active site 863638006366 Putative motility protein; Region: YjfB_motility; pfam14070 863638006367 Exopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3955 863638006368 Exopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3955 863638006369 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 863638006370 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 863638006371 pseudaminic acid synthase; Region: PseI; TIGR03586 863638006372 NeuB family; Region: NeuB; pfam03102 863638006373 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 863638006374 NeuB binding interface [polypeptide binding]; other site 863638006375 putative substrate binding site [chemical binding]; other site 863638006376 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638006377 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 863638006378 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 863638006379 ATP-grasp domain; Region: ATP-grasp_3; pfam02655 863638006380 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 863638006381 ligand binding site; other site 863638006382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638006383 motif II; other site 863638006384 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 863638006385 dimer interface [polypeptide binding]; other site 863638006386 substrate binding site [chemical binding]; other site 863638006387 metal binding site [ion binding]; metal-binding site 863638006388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 863638006389 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 863638006390 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 863638006391 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 863638006392 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 863638006393 NAD(P) binding site [chemical binding]; other site 863638006394 homodimer interface [polypeptide binding]; other site 863638006395 substrate binding site [chemical binding]; other site 863638006396 active site 863638006397 Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain [General function prediction only]; Region: COG4310 863638006398 M28 Zn-Peptidases; Region: M28_like_3; cd05644 863638006399 active site 863638006400 metal binding site [ion binding]; metal-binding site 863638006401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 863638006402 Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746 863638006403 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 863638006404 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 863638006405 Acid Phosphatase; Region: Acid_PPase; cl17256 863638006406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 863638006407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 863638006408 flagellin; Provisional; Region: PRK12804 863638006409 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 863638006410 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 863638006411 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 863638006412 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 863638006413 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 863638006414 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 863638006415 Uncharacterized flagellar protein FlaG [Cell motility and secretion]; Region: FlaG; COG1334 863638006416 RNA-binding global regulator CsrA [Signal transduction mechanisms]; Region: CsrA; COG1551 863638006417 flagellar assembly protein FliW; Provisional; Region: PRK13285 863638006418 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 863638006419 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 863638006420 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 863638006421 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 863638006422 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 863638006423 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 863638006424 FlgN protein; Region: FlgN; pfam05130 863638006425 Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747 863638006426 flagellar motor switch protein; Validated; Region: PRK08119 863638006427 CheC-like family; Region: CheC; pfam04509 863638006428 CheC-like family; Region: CheC; pfam04509 863638006429 flagellar motor switch protein FliN; Region: fliN; TIGR02480 863638006430 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 863638006431 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 863638006432 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 863638006433 Response regulator receiver domain; Region: Response_reg; pfam00072 863638006434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638006435 active site 863638006436 phosphorylation site [posttranslational modification] 863638006437 intermolecular recognition site; other site 863638006438 dimerization interface [polypeptide binding]; other site 863638006439 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 863638006440 CheC-like family; Region: CheC; pfam04509 863638006441 CheC-like family; Region: CheC; pfam04509 863638006442 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 863638006443 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 863638006444 putative binding surface; other site 863638006445 active site 863638006446 P2 response regulator binding domain; Region: P2; pfam07194 863638006447 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 863638006448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638006449 ATP binding site [chemical binding]; other site 863638006450 Mg2+ binding site [ion binding]; other site 863638006451 G-X-G motif; other site 863638006452 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 863638006453 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 863638006454 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 863638006455 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 863638006456 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 863638006457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638006458 active site 863638006459 phosphorylation site [posttranslational modification] 863638006460 intermolecular recognition site; other site 863638006461 dimerization interface [polypeptide binding]; other site 863638006462 CheB methylesterase; Region: CheB_methylest; pfam01339 863638006463 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13490 863638006464 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 863638006465 Uncharacterized conserved protein [Function unknown]; Region: COG1315 863638006466 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 863638006467 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 863638006468 homodimer interface [polypeptide binding]; other site 863638006469 substrate-cofactor binding pocket; other site 863638006470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638006471 catalytic residue [active] 863638006472 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 863638006473 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 863638006474 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 863638006475 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 863638006476 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 863638006477 dimer interface [polypeptide binding]; other site 863638006478 PYR/PP interface [polypeptide binding]; other site 863638006479 TPP binding site [chemical binding]; other site 863638006480 substrate binding site [chemical binding]; other site 863638006481 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 863638006482 Domain of unknown function; Region: EKR; smart00890 863638006483 4Fe-4S binding domain; Region: Fer4_6; pfam12837 863638006484 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 863638006485 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 863638006486 TPP-binding site [chemical binding]; other site 863638006487 dimer interface [polypeptide binding]; other site 863638006488 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 863638006489 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 863638006490 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 863638006491 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 863638006492 active site 863638006493 homodimer interface [polypeptide binding]; other site 863638006494 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 863638006495 DHH family; Region: DHH; pfam01368 863638006496 DHHA1 domain; Region: DHHA1; pfam02272 863638006497 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 863638006498 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 863638006499 Ligand Binding Site [chemical binding]; other site 863638006500 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 863638006501 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 863638006502 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 863638006503 catalytic residue [active] 863638006504 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 863638006505 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 863638006506 dimer interface [polypeptide binding]; other site 863638006507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638006508 catalytic residue [active] 863638006509 Predicted transcriptional regulator [Transcription]; Region: COG1959 863638006510 Transcriptional regulator; Region: Rrf2; cl17282 863638006511 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 863638006512 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 863638006513 ligand binding site; other site 863638006514 oligomer interface; other site 863638006515 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 863638006516 dimer interface [polypeptide binding]; other site 863638006517 N-terminal domain interface [polypeptide binding]; other site 863638006518 sulfate 1 binding site; other site 863638006519 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 863638006520 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 863638006521 ligand binding site; other site 863638006522 oligomer interface; other site 863638006523 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 863638006524 dimer interface [polypeptide binding]; other site 863638006525 N-terminal domain interface [polypeptide binding]; other site 863638006526 sulfate 1 binding site; other site 863638006527 glycogen synthase; Provisional; Region: glgA; PRK00654 863638006528 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 863638006529 ADP-binding pocket [chemical binding]; other site 863638006530 homodimer interface [polypeptide binding]; other site 863638006531 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 863638006532 starch-binding site 2 [chemical binding]; other site 863638006533 starch-binding site 1 [chemical binding]; other site 863638006534 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 863638006535 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 863638006536 metal-binding site [ion binding] 863638006537 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 863638006538 Soluble P-type ATPase [General function prediction only]; Region: COG4087 863638006539 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 863638006540 dimerization interface [polypeptide binding]; other site 863638006541 putative DNA binding site [nucleotide binding]; other site 863638006542 putative Zn2+ binding site [ion binding]; other site 863638006543 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 863638006544 active site 863638006545 dimer interface [polypeptide binding]; other site 863638006546 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 863638006547 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 863638006548 Ligand Binding Site [chemical binding]; other site 863638006549 Molecular Tunnel; other site 863638006550 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 863638006551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638006552 active site 863638006553 motif I; other site 863638006554 motif II; other site 863638006555 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 863638006556 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 863638006557 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 863638006558 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 863638006559 TAP-like protein; Region: Abhydrolase_4; pfam08386 863638006560 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 863638006561 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 863638006562 putative catalytic residues [active] 863638006563 catalytic nucleophile [active] 863638006564 Recombinase; Region: Recombinase; pfam07508 863638006565 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 863638006566 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 863638006567 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 863638006568 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 863638006569 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 863638006570 active site 863638006571 tetramer interface; other site 863638006572 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 863638006573 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 863638006574 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 863638006575 potential frameshift: common BLAST hit: gi|337737469|ref|YP_004636916.1| alpha-glucosidase 863638006576 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 863638006577 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 863638006578 active site 863638006579 catalytic site [active] 863638006580 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 863638006581 Fn3 associated; Region: Fn3_assoc; pfam13287 863638006582 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 863638006583 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 863638006584 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 863638006585 Histidine kinase; Region: HisKA_3; pfam07730 863638006586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638006587 ATP binding site [chemical binding]; other site 863638006588 Mg2+ binding site [ion binding]; other site 863638006589 G-X-G motif; other site 863638006590 Response regulator receiver domain; Region: Response_reg; pfam00072 863638006591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638006592 active site 863638006593 phosphorylation site [posttranslational modification] 863638006594 intermolecular recognition site; other site 863638006595 dimerization interface [polypeptide binding]; other site 863638006596 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 863638006597 DNA binding residues [nucleotide binding] 863638006598 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 863638006599 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 863638006600 FtsX-like permease family; Region: FtsX; pfam02687 863638006601 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638006602 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 863638006603 Walker A/P-loop; other site 863638006604 ATP binding site [chemical binding]; other site 863638006605 Q-loop/lid; other site 863638006606 ABC transporter signature motif; other site 863638006607 Walker B; other site 863638006608 D-loop; other site 863638006609 H-loop/switch region; other site 863638006610 HTH domain; Region: HTH_11; cl17392 863638006611 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 863638006612 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 863638006613 inhibitor-cofactor binding pocket; inhibition site 863638006614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638006615 catalytic residue [active] 863638006616 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 863638006617 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 863638006618 generic binding surface II; other site 863638006619 generic binding surface I; other site 863638006620 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638006621 Zn2+ binding site [ion binding]; other site 863638006622 Mg2+ binding site [ion binding]; other site 863638006623 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 863638006624 Part of AAA domain; Region: AAA_19; pfam13245 863638006625 Family description; Region: UvrD_C_2; pfam13538 863638006626 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 863638006627 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 863638006628 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 863638006629 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 863638006630 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 863638006631 dimer interface [polypeptide binding]; other site 863638006632 active site 863638006633 glycine-pyridoxal phosphate binding site [chemical binding]; other site 863638006634 folate binding site [chemical binding]; other site 863638006635 Uncharacterized conserved protein [Function unknown]; Region: COG2966 863638006636 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 863638006637 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 863638006638 Uncharacterized conserved protein [Function unknown]; Region: COG3610 863638006639 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 863638006640 putative homotetramer interface [polypeptide binding]; other site 863638006641 putative homodimer interface [polypeptide binding]; other site 863638006642 putative allosteric switch controlling residues; other site 863638006643 putative metal binding site [ion binding]; other site 863638006644 putative homodimer-homodimer interface [polypeptide binding]; other site 863638006645 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 863638006646 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 863638006647 dimer interface [polypeptide binding]; other site 863638006648 anticodon binding site; other site 863638006649 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 863638006650 homodimer interface [polypeptide binding]; other site 863638006651 motif 1; other site 863638006652 active site 863638006653 motif 2; other site 863638006654 GAD domain; Region: GAD; pfam02938 863638006655 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 863638006656 motif 3; other site 863638006657 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 863638006658 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638006659 FeS/SAM binding site; other site 863638006660 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 863638006661 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 863638006662 putative active site [active] 863638006663 dimerization interface [polypeptide binding]; other site 863638006664 putative tRNAtyr binding site [nucleotide binding]; other site 863638006665 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 863638006666 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638006667 Zn2+ binding site [ion binding]; other site 863638006668 Mg2+ binding site [ion binding]; other site 863638006669 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 863638006670 synthetase active site [active] 863638006671 NTP binding site [chemical binding]; other site 863638006672 metal binding site [ion binding]; metal-binding site 863638006673 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 863638006674 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 863638006675 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 863638006676 active site 863638006677 Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608 863638006678 DHH family; Region: DHH; pfam01368 863638006679 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 863638006680 Protein export membrane protein; Region: SecD_SecF; pfam02355 863638006681 protein-export membrane protein SecD; Region: secD; TIGR01129 863638006682 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 863638006683 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 863638006684 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638006685 FeS/SAM binding site; other site 863638006686 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 863638006687 Protein of unknown function (DUF4001); Region: DUF4001; cl14848 863638006688 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 863638006689 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 863638006690 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 863638006691 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 863638006692 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 863638006693 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 863638006694 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 863638006695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638006696 Walker A motif; other site 863638006697 ATP binding site [chemical binding]; other site 863638006698 Walker B motif; other site 863638006699 arginine finger; other site 863638006700 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 863638006701 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 863638006702 RuvA N terminal domain; Region: RuvA_N; pfam01330 863638006703 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 863638006704 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 863638006705 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 863638006706 putative catalytic cysteine [active] 863638006707 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 863638006708 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 863638006709 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 863638006710 carboxyltransferase (CT) interaction site; other site 863638006711 biotinylation site [posttranslational modification]; other site 863638006712 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 863638006713 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 863638006714 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 863638006715 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 863638006716 active site 863638006717 Zn binding site [ion binding]; other site 863638006718 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638006719 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006720 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006721 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638006722 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006723 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006724 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006725 hypothetical protein; Validated; Region: PRK00110 863638006726 Uncharacterized conserved protein [Function unknown]; Region: COG1739 863638006727 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 863638006728 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 863638006729 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 863638006730 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 863638006731 DNA-binding site [nucleotide binding]; DNA binding site 863638006732 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 863638006733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638006734 homodimer interface [polypeptide binding]; other site 863638006735 catalytic residue [active] 863638006736 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 863638006737 active site 863638006738 NTP binding site [chemical binding]; other site 863638006739 metal binding triad [ion binding]; metal-binding site 863638006740 antibiotic binding site [chemical binding]; other site 863638006741 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 863638006742 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 863638006743 HflX GTPase family; Region: HflX; cd01878 863638006744 G1 box; other site 863638006745 GTP/Mg2+ binding site [chemical binding]; other site 863638006746 Switch I region; other site 863638006747 G2 box; other site 863638006748 G3 box; other site 863638006749 Switch II region; other site 863638006750 G4 box; other site 863638006751 G5 box; other site 863638006752 sporulation protein YunB; Region: spo_yunB; TIGR02832 863638006753 Transglycosylase; Region: Transgly; pfam00912 863638006754 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 863638006755 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 863638006756 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 863638006757 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 863638006758 stage V sporulation protein AD; Validated; Region: PRK08304 863638006759 stage V sporulation protein AD; Provisional; Region: PRK12404 863638006760 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 863638006761 sporulation sigma factor SigF; Validated; Region: PRK05572 863638006762 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 863638006763 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 863638006764 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 863638006765 DNA binding residues [nucleotide binding] 863638006766 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 863638006767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638006768 ATP binding site [chemical binding]; other site 863638006769 Mg2+ binding site [ion binding]; other site 863638006770 G-X-G motif; other site 863638006771 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 863638006772 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 863638006773 anti sigma factor interaction site; other site 863638006774 regulatory phosphorylation site [posttranslational modification]; other site 863638006775 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 863638006776 Methyltransferase domain; Region: Methyltransf_26; pfam13659 863638006777 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 863638006778 Methenyl tetrahydrofolate cyclohydrolase [Amino acid transport and metabolism]; Region: COG3404 863638006779 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 863638006780 putative FMN binding site [chemical binding]; other site 863638006781 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 863638006782 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 863638006783 Probable Catalytic site; other site 863638006784 metal-binding site 863638006785 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638006786 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 863638006787 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 863638006788 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 863638006789 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 863638006790 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 863638006791 NADP binding site [chemical binding]; other site 863638006792 active site 863638006793 putative substrate binding site [chemical binding]; other site 863638006794 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 863638006795 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 863638006796 putative active site [active] 863638006797 putative metal binding site [ion binding]; other site 863638006798 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 863638006799 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 863638006800 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 863638006801 O-Antigen ligase; Region: Wzy_C; pfam04932 863638006802 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 863638006803 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 863638006804 Probable Catalytic site; other site 863638006805 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 863638006806 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 863638006807 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 863638006808 Probable Catalytic site; other site 863638006809 metal-binding site 863638006810 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 863638006811 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 863638006812 Ligand binding site; other site 863638006813 Putative Catalytic site; other site 863638006814 DXD motif; other site 863638006815 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638006816 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006817 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006818 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006819 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006820 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006821 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006822 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 863638006823 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 863638006824 Lysozyme subfamily 2; Region: LYZ2; smart00047 863638006825 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638006826 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 863638006827 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 863638006828 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 863638006829 Probable Catalytic site; other site 863638006830 metal-binding site 863638006831 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638006832 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 863638006833 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 863638006834 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 863638006835 Walker A/P-loop; other site 863638006836 ATP binding site [chemical binding]; other site 863638006837 Q-loop/lid; other site 863638006838 ABC transporter signature motif; other site 863638006839 Walker B; other site 863638006840 D-loop; other site 863638006841 H-loop/switch region; other site 863638006842 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 863638006843 putative carbohydrate binding site [chemical binding]; other site 863638006844 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 863638006845 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 863638006846 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 863638006847 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 863638006848 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 863638006849 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 863638006850 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 863638006851 NAD binding site [chemical binding]; other site 863638006852 substrate binding site [chemical binding]; other site 863638006853 homodimer interface [polypeptide binding]; other site 863638006854 active site 863638006855 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 863638006856 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 863638006857 substrate binding site; other site 863638006858 tetramer interface; other site 863638006859 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 863638006860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 863638006861 NAD(P) binding site [chemical binding]; other site 863638006862 active site 863638006863 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 863638006864 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 863638006865 active site 863638006866 tetramer interface; other site 863638006867 Tetratricopeptide repeat; Region: TPR_12; pfam13424 863638006868 Tetratricopeptide repeat; Region: TPR_12; pfam13424 863638006869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638006870 binding surface 863638006871 TPR motif; other site 863638006872 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 863638006873 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 863638006874 active site 863638006875 substrate binding site [chemical binding]; other site 863638006876 metal binding site [ion binding]; metal-binding site 863638006877 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 863638006878 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 863638006879 homodimer interface [polypeptide binding]; other site 863638006880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638006881 catalytic residue [active] 863638006882 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 863638006883 Uncharacterized conserved protein [Function unknown]; Region: COG1683 863638006884 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 863638006885 MutS domain III; Region: MutS_III; pfam05192 863638006886 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 863638006887 Walker A/P-loop; other site 863638006888 ATP binding site [chemical binding]; other site 863638006889 Q-loop/lid; other site 863638006890 ABC transporter signature motif; other site 863638006891 Walker B; other site 863638006892 D-loop; other site 863638006893 H-loop/switch region; other site 863638006894 Smr domain; Region: Smr; pfam01713 863638006895 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 863638006896 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 863638006897 Peptidase family U32; Region: Peptidase_U32; pfam01136 863638006898 Collagenase; Region: DUF3656; pfam12392 863638006899 Peptidase family U32; Region: Peptidase_U32; cl03113 863638006900 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 863638006901 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 863638006902 trimer interface [polypeptide binding]; other site 863638006903 active site 863638006904 substrate binding site [chemical binding]; other site 863638006905 CoA binding site [chemical binding]; other site 863638006906 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638006907 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 863638006908 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 863638006909 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 863638006910 active site 863638006911 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 863638006912 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 863638006913 active site 863638006914 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 863638006915 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 863638006916 Probable Catalytic site; other site 863638006917 metal-binding site 863638006918 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 863638006919 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 863638006920 active site 863638006921 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 863638006922 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 863638006923 inhibitor-cofactor binding pocket; inhibition site 863638006924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638006925 catalytic residue [active] 863638006926 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 863638006927 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 863638006928 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 863638006929 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 863638006930 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 863638006931 catalytic residue [active] 863638006932 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 863638006933 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 863638006934 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 863638006935 putative tRNA-binding site [nucleotide binding]; other site 863638006936 B3/4 domain; Region: B3_4; pfam03483 863638006937 tRNA synthetase B5 domain; Region: B5; smart00874 863638006938 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 863638006939 dimer interface [polypeptide binding]; other site 863638006940 motif 1; other site 863638006941 motif 3; other site 863638006942 motif 2; other site 863638006943 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 863638006944 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 863638006945 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 863638006946 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 863638006947 dimer interface [polypeptide binding]; other site 863638006948 motif 1; other site 863638006949 active site 863638006950 motif 2; other site 863638006951 motif 3; other site 863638006952 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 863638006953 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 863638006954 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 863638006955 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 863638006956 23S rRNA binding site [nucleotide binding]; other site 863638006957 L21 binding site [polypeptide binding]; other site 863638006958 L13 binding site [polypeptide binding]; other site 863638006959 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 863638006960 Translation initiation factor 3 (IF-3) [Translation, ribosomal structure and biogenesis]; Region: InfC; COG0290 863638006961 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 863638006962 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 863638006963 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 863638006964 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 863638006965 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 863638006966 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 863638006967 active site 863638006968 dimer interface [polypeptide binding]; other site 863638006969 motif 1; other site 863638006970 motif 2; other site 863638006971 motif 3; other site 863638006972 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 863638006973 anticodon binding site; other site 863638006974 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 863638006975 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 863638006976 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006977 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638006978 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006979 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006980 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638006981 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638006982 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006983 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006984 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006985 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006986 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006987 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638006988 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 863638006989 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 863638006990 dimerization interface [polypeptide binding]; other site 863638006991 domain crossover interface; other site 863638006992 redox-dependent activation switch; other site 863638006993 Methyltransferase domain; Region: Methyltransf_31; pfam13847 863638006994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638006995 S-adenosylmethionine binding site [chemical binding]; other site 863638006996 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 863638006997 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 863638006998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638006999 dimer interface [polypeptide binding]; other site 863638007000 conserved gate region; other site 863638007001 putative PBP binding loops; other site 863638007002 ABC-ATPase subunit interface; other site 863638007003 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 863638007004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638007005 dimer interface [polypeptide binding]; other site 863638007006 conserved gate region; other site 863638007007 putative PBP binding loops; other site 863638007008 ABC-ATPase subunit interface; other site 863638007009 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 863638007010 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 863638007011 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 863638007012 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 863638007013 dimer interface [polypeptide binding]; other site 863638007014 active site 863638007015 catalytic residue [active] 863638007016 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 863638007017 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 863638007018 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 863638007019 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 863638007020 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 863638007021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638007022 homodimer interface [polypeptide binding]; other site 863638007023 catalytic residue [active] 863638007024 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 863638007025 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 863638007026 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 863638007027 active site 863638007028 trimer interface [polypeptide binding]; other site 863638007029 substrate binding site [chemical binding]; other site 863638007030 CoA binding site [chemical binding]; other site 863638007031 single-stranded DNA-binding protein; Provisional; Region: PRK05813 863638007032 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 863638007033 dimer interface [polypeptide binding]; other site 863638007034 ssDNA binding site [nucleotide binding]; other site 863638007035 tetramer (dimer of dimers) interface [polypeptide binding]; other site 863638007036 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 863638007037 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 863638007038 NodB motif; other site 863638007039 active site 863638007040 catalytic site [active] 863638007041 metal binding site [ion binding]; metal-binding site 863638007042 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 863638007043 Uncharacterized conserved protein [Function unknown]; Region: COG3391 863638007044 TSCPD domain; Region: TSCPD; cl14834 863638007045 acetylornithine aminotransferase; Provisional; Region: PRK02627 863638007046 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 863638007047 inhibitor-cofactor binding pocket; inhibition site 863638007048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638007049 catalytic residue [active] 863638007050 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 863638007051 homohexameric interface [polypeptide binding]; other site 863638007052 feedback inhibition sensing region; other site 863638007053 nucleotide binding site [chemical binding]; other site 863638007054 N-acetyl-L-glutamate binding site [chemical binding]; other site 863638007055 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 863638007056 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 863638007057 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 863638007058 heterotetramer interface [polypeptide binding]; other site 863638007059 active site pocket [active] 863638007060 cleavage site 863638007061 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 863638007062 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 863638007063 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 863638007064 Walker A/P-loop; other site 863638007065 ATP binding site [chemical binding]; other site 863638007066 Q-loop/lid; other site 863638007067 ABC transporter signature motif; other site 863638007068 Walker B; other site 863638007069 D-loop; other site 863638007070 H-loop/switch region; other site 863638007071 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 863638007072 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 863638007073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638007074 Walker A/P-loop; other site 863638007075 ATP binding site [chemical binding]; other site 863638007076 Q-loop/lid; other site 863638007077 ABC transporter signature motif; other site 863638007078 Walker B; other site 863638007079 D-loop; other site 863638007080 H-loop/switch region; other site 863638007081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 863638007082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 863638007083 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 863638007084 dimerization interface [polypeptide binding]; other site 863638007085 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 863638007086 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 863638007087 active site 863638007088 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 863638007089 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 863638007090 NodB motif; other site 863638007091 active site 863638007092 catalytic site [active] 863638007093 Zn binding site [ion binding]; other site 863638007094 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 863638007095 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 863638007096 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 863638007097 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 863638007098 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 863638007099 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 863638007100 active site 863638007101 HIGH motif; other site 863638007102 nucleotide binding site [chemical binding]; other site 863638007103 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 863638007104 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 863638007105 active site 863638007106 KMSKS motif; other site 863638007107 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 863638007108 tRNA binding surface [nucleotide binding]; other site 863638007109 anticodon binding site; other site 863638007110 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 863638007111 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 863638007112 active site 863638007113 ATP binding site [chemical binding]; other site 863638007114 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 863638007115 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 863638007116 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 863638007117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 863638007118 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 863638007119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 863638007120 Tetratricopeptide repeat; Region: TPR_12; pfam13424 863638007121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638007122 binding surface 863638007123 TPR motif; other site 863638007124 TPR repeat; Region: TPR_11; pfam13414 863638007125 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 863638007126 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 863638007127 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 863638007128 active site 863638007129 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 863638007130 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638007131 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 863638007132 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 863638007133 Response regulator receiver domain; Region: Response_reg; pfam00072 863638007134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638007135 active site 863638007136 phosphorylation site [posttranslational modification] 863638007137 intermolecular recognition site; other site 863638007138 dimerization interface [polypeptide binding]; other site 863638007139 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 863638007140 active site 863638007141 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 863638007142 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 863638007143 RecX family; Region: RecX; cl00936 863638007144 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 863638007145 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 863638007146 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 863638007147 Uncharacterized conserved protein [Function unknown]; Region: COG4127 863638007148 Predicted membrane protein [Function unknown]; Region: COG4708 863638007149 Uncharacterized conserved protein [Function unknown]; Region: COG1543 863638007150 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 863638007151 active site 863638007152 substrate binding site [chemical binding]; other site 863638007153 catalytic site [active] 863638007154 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 863638007155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 863638007156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 863638007157 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 863638007158 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 863638007159 Cache domain; Region: Cache_1; pfam02743 863638007160 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638007161 dimerization interface [polypeptide binding]; other site 863638007162 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 863638007163 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638007164 dimer interface [polypeptide binding]; other site 863638007165 putative CheW interface [polypeptide binding]; other site 863638007166 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 863638007167 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638007168 FeS/SAM binding site; other site 863638007169 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638007170 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 863638007171 active site 863638007172 motif I; other site 863638007173 motif II; other site 863638007174 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 863638007175 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 863638007176 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 863638007177 active site 863638007178 nucleophile elbow; other site 863638007179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 863638007180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 863638007181 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 863638007182 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 863638007183 PilZ domain; Region: PilZ; pfam07238 863638007184 transcription elongation factor GreA; Region: greA; TIGR01462 863638007185 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 863638007186 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 863638007187 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 863638007188 Sulfatase; Region: Sulfatase; pfam00884 863638007189 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 863638007190 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 863638007191 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 863638007192 protein binding site [polypeptide binding]; other site 863638007193 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638007194 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638007195 dimerization interface [polypeptide binding]; other site 863638007196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638007197 dimer interface [polypeptide binding]; other site 863638007198 phosphorylation site [posttranslational modification] 863638007199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638007200 ATP binding site [chemical binding]; other site 863638007201 Mg2+ binding site [ion binding]; other site 863638007202 G-X-G motif; other site 863638007203 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638007204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638007205 active site 863638007206 phosphorylation site [posttranslational modification] 863638007207 intermolecular recognition site; other site 863638007208 dimerization interface [polypeptide binding]; other site 863638007209 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638007210 DNA binding site [nucleotide binding] 863638007211 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 863638007212 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 863638007213 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 863638007214 active site 863638007215 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 863638007216 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 863638007217 putative ligand binding site [chemical binding]; other site 863638007218 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 863638007219 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 863638007220 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 863638007221 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 863638007222 ABC-ATPase subunit interface; other site 863638007223 dimer interface [polypeptide binding]; other site 863638007224 putative PBP binding regions; other site 863638007225 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 863638007226 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 863638007227 Walker A/P-loop; other site 863638007228 ATP binding site [chemical binding]; other site 863638007229 Q-loop/lid; other site 863638007230 ABC transporter signature motif; other site 863638007231 Walker B; other site 863638007232 D-loop; other site 863638007233 H-loop/switch region; other site 863638007234 Uncharacterized protein containing a Zn-finger-like domain [General function prediction only]; Region: COG2158 863638007235 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 863638007236 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 863638007237 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 863638007238 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 863638007239 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 863638007240 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 863638007241 Desulfoferrodoxin [Energy production and conversion]; Region: COG2033 863638007242 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cd00524 863638007243 non-heme iron binding site [ion binding]; other site 863638007244 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 863638007245 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 863638007246 DNA binding residues [nucleotide binding] 863638007247 Methyltransferase domain; Region: Methyltransf_23; pfam13489 863638007248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638007249 S-adenosylmethionine binding site [chemical binding]; other site 863638007250 flavodoxin; Provisional; Region: PRK05569 863638007251 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 863638007252 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 863638007253 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; Region: PorB_KorB; TIGR02177 863638007254 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 863638007255 TPP-binding site [chemical binding]; other site 863638007256 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 863638007257 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 863638007258 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 863638007259 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 863638007260 dimer interface [polypeptide binding]; other site 863638007261 PYR/PP interface [polypeptide binding]; other site 863638007262 TPP binding site [chemical binding]; other site 863638007263 substrate binding site [chemical binding]; other site 863638007264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3220 863638007265 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 863638007266 dimer interface [polypeptide binding]; other site 863638007267 ligand binding site [chemical binding]; other site 863638007268 Predicted secreted protein [Function unknown]; Region: COG5513 863638007269 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 863638007270 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638007271 Coenzyme A binding pocket [chemical binding]; other site 863638007272 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 863638007273 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 863638007274 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638007275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638007276 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 863638007277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638007278 non-specific DNA binding site [nucleotide binding]; other site 863638007279 salt bridge; other site 863638007280 sequence-specific DNA binding site [nucleotide binding]; other site 863638007281 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 863638007282 active site 863638007283 catalytic residues [active] 863638007284 metal binding site [ion binding]; metal-binding site 863638007285 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 863638007286 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 863638007287 hypothetical protein; Provisional; Region: PRK11479 863638007288 CAAX protease self-immunity; Region: Abi; pfam02517 863638007289 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 863638007290 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 863638007291 Coenzyme A binding pocket [chemical binding]; other site 863638007292 topology modulation protein; Reviewed; Region: PRK08118 863638007293 AAA domain; Region: AAA_17; pfam13207 863638007294 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 863638007295 active site clefts [active] 863638007296 zinc binding site [ion binding]; other site 863638007297 dimer interface [polypeptide binding]; other site 863638007298 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 863638007299 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638007300 dimer interface [polypeptide binding]; other site 863638007301 putative CheW interface [polypeptide binding]; other site 863638007302 Predicted membrane protein [Function unknown]; Region: COG4129 863638007303 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 863638007304 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 863638007305 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 863638007306 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 863638007307 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 863638007308 MarR family; Region: MarR_2; pfam12802 863638007309 MarR family; Region: MarR_2; cl17246 863638007310 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 863638007311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638007312 Coenzyme A binding pocket [chemical binding]; other site 863638007313 Hemerythrin-like domain; Region: Hr-like; cd12108 863638007314 Fe binding site [ion binding]; other site 863638007315 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638007316 non-specific DNA binding site [nucleotide binding]; other site 863638007317 salt bridge; other site 863638007318 sequence-specific DNA binding site [nucleotide binding]; other site 863638007319 Tetratricopeptide repeat; Region: TPR_12; pfam13424 863638007320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638007321 binding surface 863638007322 TPR motif; other site 863638007323 Tetratricopeptide repeat; Region: TPR_12; pfam13424 863638007324 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638007325 Coenzyme A binding pocket [chemical binding]; other site 863638007326 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 863638007327 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638007328 non-specific DNA binding site [nucleotide binding]; other site 863638007329 salt bridge; other site 863638007330 sequence-specific DNA binding site [nucleotide binding]; other site 863638007331 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 863638007332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 863638007333 motif II; other site 863638007334 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 863638007335 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 863638007336 ACS interaction site; other site 863638007337 CODH interaction site; other site 863638007338 cubane metal cluster (B-cluster) [ion binding]; other site 863638007339 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 863638007340 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 863638007341 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 863638007342 dimer interface [polypeptide binding]; other site 863638007343 PYR/PP interface [polypeptide binding]; other site 863638007344 TPP binding site [chemical binding]; other site 863638007345 substrate binding site [chemical binding]; other site 863638007346 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 863638007347 Domain of unknown function; Region: EKR; smart00890 863638007348 4Fe-4S binding domain; Region: Fer4_6; pfam12837 863638007349 4Fe-4S binding domain; Region: Fer4; pfam00037 863638007350 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 863638007351 TPP-binding site [chemical binding]; other site 863638007352 dimer interface [polypeptide binding]; other site 863638007353 membrane protein; Provisional; Region: PRK14413 863638007354 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 863638007355 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 863638007356 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 863638007357 Stage II sporulation protein; Region: SpoIID; pfam08486 863638007358 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 863638007359 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 863638007360 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 863638007361 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 863638007362 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 863638007363 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 863638007364 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 863638007365 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 863638007366 putative FMN binding site [chemical binding]; other site 863638007367 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 863638007368 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638007369 Coenzyme A binding pocket [chemical binding]; other site 863638007370 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 863638007371 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 863638007372 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 863638007373 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 863638007374 Beta-galactosidase, domain 3; Region: BetaGal_dom3; pfam13363 863638007375 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 863638007376 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 863638007377 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 863638007378 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 863638007379 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 863638007380 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 863638007381 active site 863638007382 Zn binding site [ion binding]; other site 863638007383 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 863638007384 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 863638007385 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 863638007386 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 863638007387 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 863638007388 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 863638007389 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 863638007390 Ligand binding site; other site 863638007391 Putative Catalytic site; other site 863638007392 DXD motif; other site 863638007393 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 863638007394 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 863638007395 DXD motif; other site 863638007396 exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110 863638007397 Predicted integral membrane protein [Function unknown]; Region: COG5617 863638007398 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 863638007399 GtrA-like protein; Region: GtrA; pfam04138 863638007400 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 863638007401 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 863638007402 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 863638007403 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 863638007404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638007405 S-adenosylmethionine binding site [chemical binding]; other site 863638007406 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638007407 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638007408 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638007409 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638007410 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638007411 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638007412 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638007413 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638007414 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638007415 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638007416 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638007417 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638007418 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638007419 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638007420 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638007421 Zn2+ binding site [ion binding]; other site 863638007422 Mg2+ binding site [ion binding]; other site 863638007423 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 863638007424 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638007425 Zn2+ binding site [ion binding]; other site 863638007426 Mg2+ binding site [ion binding]; other site 863638007427 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 863638007428 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 863638007429 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 863638007430 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 863638007431 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638007432 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 863638007433 putative ADP-binding pocket [chemical binding]; other site 863638007434 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 863638007435 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 863638007436 active site 863638007437 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638007438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638007439 ATP binding site [chemical binding]; other site 863638007440 G-X-G motif; other site 863638007441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638007442 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 863638007443 Coenzyme A binding pocket [chemical binding]; other site 863638007444 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 863638007445 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cd01342 863638007446 FAD binding domain; Region: FAD_binding_4; pfam01565 863638007447 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 863638007448 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 863638007449 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 863638007450 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 863638007451 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 863638007452 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 863638007453 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 863638007454 Ligand binding site [chemical binding]; other site 863638007455 Electron transfer flavoprotein domain; Region: ETF; pfam01012 863638007456 Transcriptional regulators [Transcription]; Region: FadR; COG2186 863638007457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 863638007458 DNA-binding site [nucleotide binding]; DNA binding site 863638007459 FCD domain; Region: FCD; pfam07729 863638007460 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 863638007461 Cache domain; Region: Cache_1; pfam02743 863638007462 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 863638007463 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638007464 dimerization interface [polypeptide binding]; other site 863638007465 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638007466 dimer interface [polypeptide binding]; other site 863638007467 putative CheW interface [polypeptide binding]; other site 863638007468 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 863638007469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4295 863638007470 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 863638007471 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 863638007472 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 863638007473 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 863638007474 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 863638007475 RNA/DNA hybrid binding site [nucleotide binding]; other site 863638007476 active site 863638007477 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638007478 salt bridge; other site 863638007479 non-specific DNA binding site [nucleotide binding]; other site 863638007480 sequence-specific DNA binding site [nucleotide binding]; other site 863638007481 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 863638007482 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 863638007483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 863638007484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638007485 Coenzyme A binding pocket [chemical binding]; other site 863638007486 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 863638007487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638007488 Coenzyme A binding pocket [chemical binding]; other site 863638007489 GGGtGRT protein; Region: GGGtGRT; pfam14057 863638007490 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 863638007491 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 863638007492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 863638007493 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 863638007494 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 863638007495 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 863638007496 Predicted transcriptional regulators [Transcription]; Region: COG1733 863638007497 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 863638007498 dimerization interface [polypeptide binding]; other site 863638007499 putative DNA binding site [nucleotide binding]; other site 863638007500 putative Zn2+ binding site [ion binding]; other site 863638007501 Uncharacterized conserved protein [Function unknown]; Region: COG5015 863638007502 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 863638007503 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 863638007504 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638007505 Coenzyme A binding pocket [chemical binding]; other site 863638007506 Phosphotransferase enzyme family; Region: APH; pfam01636 863638007507 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 863638007508 active site 863638007509 substrate binding site [chemical binding]; other site 863638007510 ATP binding site [chemical binding]; other site 863638007511 Methyltransferase domain; Region: Methyltransf_23; pfam13489 863638007512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638007513 S-adenosylmethionine binding site [chemical binding]; other site 863638007514 Methyltransferase domain; Region: Methyltransf_23; pfam13489 863638007515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638007516 S-adenosylmethionine binding site [chemical binding]; other site 863638007517 Rubrerythrin [Energy production and conversion]; Region: COG1592 863638007518 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 863638007519 binuclear metal center [ion binding]; other site 863638007520 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 863638007521 iron binding site [ion binding]; other site 863638007522 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 863638007523 active site 863638007524 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 863638007525 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 863638007526 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 863638007527 DXD motif; other site 863638007528 exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110 863638007529 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 863638007530 Firmicu-CTERM domain; Region: Firmicu_CTERM; TIGR04145 863638007531 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 863638007532 Predicted integral membrane protein [Function unknown]; Region: COG5617 863638007533 Predicted membrane protein [Function unknown]; Region: COG1511 863638007534 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 863638007535 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 863638007536 Predicted membrane protein [Function unknown]; Region: COG1511 863638007537 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 863638007538 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 863638007539 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638007540 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638007541 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638007542 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638007543 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638007544 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638007545 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638007546 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 863638007547 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 863638007548 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 863638007549 metal binding site [ion binding]; metal-binding site 863638007550 active site 863638007551 I-site; other site 863638007552 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 863638007553 Ligand binding site; other site 863638007554 Putative Catalytic site; other site 863638007555 DXD motif; other site 863638007556 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 863638007557 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 863638007558 DXD motif; other site 863638007559 exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110 863638007560 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 863638007561 putative ligand binding site [chemical binding]; other site 863638007562 Firmicu-CTERM domain; Region: Firmicu_CTERM; TIGR04145 863638007563 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 863638007564 Predicted integral membrane protein [Function unknown]; Region: COG5617 863638007565 Lysine efflux permease [General function prediction only]; Region: COG1279 863638007566 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 863638007567 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 863638007568 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 863638007569 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 863638007570 iron-sulfur cluster [ion binding]; other site 863638007571 [2Fe-2S] cluster binding site [ion binding]; other site 863638007572 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 863638007573 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 863638007574 spermidine synthase; Provisional; Region: PRK00811 863638007575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638007576 S-adenosylmethionine binding site [chemical binding]; other site 863638007577 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 863638007578 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 863638007579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638007580 hypothetical protein; Provisional; Region: PRK09273 863638007581 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 863638007582 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 863638007583 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 863638007584 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 863638007585 NADP binding site [chemical binding]; other site 863638007586 homodimer interface [polypeptide binding]; other site 863638007587 active site 863638007588 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 863638007589 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 863638007590 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 863638007591 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 863638007592 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 863638007593 active site 863638007594 catalytic motif [active] 863638007595 Zn binding site [ion binding]; other site 863638007596 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 863638007597 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 863638007598 hexamer (dimer of trimers) interface [polypeptide binding]; other site 863638007599 trimer interface [polypeptide binding]; other site 863638007600 substrate binding site [chemical binding]; other site 863638007601 Mn binding site [ion binding]; other site 863638007602 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 863638007603 N- and C-terminal domain interface [polypeptide binding]; other site 863638007604 D-xylulose kinase; Region: XylB; TIGR01312 863638007605 active site 863638007606 MgATP binding site [chemical binding]; other site 863638007607 catalytic site [active] 863638007608 metal binding site [ion binding]; metal-binding site 863638007609 xylulose binding site [chemical binding]; other site 863638007610 homodimer interface [polypeptide binding]; other site 863638007611 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 863638007612 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 863638007613 nucleotide binding site [chemical binding]; other site 863638007614 beta-phosphoglucomutase; Region: bPGM; TIGR01990 863638007615 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 863638007616 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638007617 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 863638007618 dinuclear metal binding motif [ion binding]; other site 863638007619 manganese transport transcriptional regulator; Provisional; Region: PRK03902 863638007620 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 863638007621 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 863638007622 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 863638007623 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 863638007624 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638007625 dimer interface [polypeptide binding]; other site 863638007626 putative CheW interface [polypeptide binding]; other site 863638007627 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 863638007628 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 863638007629 active site 863638007630 catalytic triad [active] 863638007631 oxyanion hole [active] 863638007632 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 863638007633 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638007634 Zn2+ binding site [ion binding]; other site 863638007635 Mg2+ binding site [ion binding]; other site 863638007636 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 863638007637 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 863638007638 active site 863638007639 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 863638007640 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 863638007641 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 863638007642 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 863638007643 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 863638007644 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 863638007645 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 863638007646 substrate binding site [chemical binding]; other site 863638007647 activation loop (A-loop); other site 863638007648 AAA ATPase domain; Region: AAA_16; pfam13191 863638007649 Predicted ATPase [General function prediction only]; Region: COG3899 863638007650 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 863638007651 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 863638007652 metal binding site [ion binding]; metal-binding site 863638007653 active site 863638007654 I-site; other site 863638007655 GAF domain; Region: GAF_3; pfam13492 863638007656 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 863638007657 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 863638007658 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 863638007659 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 863638007660 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 863638007661 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 863638007662 NAD(P) binding site [chemical binding]; other site 863638007663 active site 863638007664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638007665 S-adenosylmethionine binding site [chemical binding]; other site 863638007666 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 863638007667 Peptidase family M50; Region: Peptidase_M50; pfam02163 863638007668 active site 863638007669 putative substrate binding region [chemical binding]; other site 863638007670 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 863638007671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 863638007672 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 863638007673 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 863638007674 ferric uptake regulator; Provisional; Region: fur; PRK09462 863638007675 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 863638007676 metal binding site 2 [ion binding]; metal-binding site 863638007677 putative DNA binding helix; other site 863638007678 metal binding site 1 [ion binding]; metal-binding site 863638007679 dimer interface [polypeptide binding]; other site 863638007680 structural Zn2+ binding site [ion binding]; other site 863638007681 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 863638007682 G1 box; other site 863638007683 GTP/Mg2+ binding site [chemical binding]; other site 863638007684 Switch I region; other site 863638007685 G2 box; other site 863638007686 G3 box; other site 863638007687 Switch II region; other site 863638007688 G4 box; other site 863638007689 G5 box; other site 863638007690 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 863638007691 Found in ATP-dependent protease La (LON); Region: LON; smart00464 863638007692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638007693 Walker A motif; other site 863638007694 ATP binding site [chemical binding]; other site 863638007695 Walker B motif; other site 863638007696 arginine finger; other site 863638007697 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 863638007698 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 863638007699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638007700 Walker A motif; other site 863638007701 ATP binding site [chemical binding]; other site 863638007702 Walker B motif; other site 863638007703 arginine finger; other site 863638007704 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 863638007705 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 863638007706 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 863638007707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638007708 Walker A motif; other site 863638007709 ATP binding site [chemical binding]; other site 863638007710 Walker B motif; other site 863638007711 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 863638007712 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 863638007713 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 863638007714 oligomer interface [polypeptide binding]; other site 863638007715 active site residues [active] 863638007716 trigger factor; Provisional; Region: tig; PRK01490 863638007717 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 863638007718 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 863638007719 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 863638007720 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 863638007721 AP (apurinic/apyrimidinic) site pocket; other site 863638007722 Metal-binding active site; metal-binding site 863638007723 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 863638007724 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 863638007725 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 863638007726 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 863638007727 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 863638007728 ATP-grasp domain; Region: ATP-grasp_4; cl17255 863638007729 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 863638007730 IMP binding site; other site 863638007731 dimer interface [polypeptide binding]; other site 863638007732 interdomain contacts; other site 863638007733 partial ornithine binding site; other site 863638007734 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 863638007735 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 863638007736 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 863638007737 catalytic site [active] 863638007738 subunit interface [polypeptide binding]; other site 863638007739 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 863638007740 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 863638007741 Catalytic site [active] 863638007742 Predicted integral membrane protein [Function unknown]; Region: COG5523 863638007743 Predicted integral membrane protein [Function unknown]; Region: COG5523 863638007744 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 863638007745 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 863638007746 heterodimer interface [polypeptide binding]; other site 863638007747 active site 863638007748 FMN binding site [chemical binding]; other site 863638007749 homodimer interface [polypeptide binding]; other site 863638007750 substrate binding site [chemical binding]; other site 863638007751 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 863638007752 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 863638007753 FAD binding pocket [chemical binding]; other site 863638007754 FAD binding motif [chemical binding]; other site 863638007755 phosphate binding motif [ion binding]; other site 863638007756 beta-alpha-beta structure motif; other site 863638007757 NAD binding pocket [chemical binding]; other site 863638007758 Iron coordination center [ion binding]; other site 863638007759 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 863638007760 active site 863638007761 dimer interface [polypeptide binding]; other site 863638007762 Aspartate carbamoyltransferase, regulatory subunit [Nucleotide transport and metabolism]; Region: PyrI; COG1781 863638007763 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 863638007764 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 863638007765 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 863638007766 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 863638007767 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 863638007768 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 863638007769 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 863638007770 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 863638007771 Flavodoxin domain; Region: Flavodoxin_5; cl17428 863638007772 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 863638007773 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 863638007774 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 863638007775 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 863638007776 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 863638007777 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 863638007778 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 863638007779 pyruvate carboxylase; Reviewed; Region: PRK12999 863638007780 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 863638007781 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 863638007782 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 863638007783 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 863638007784 active site 863638007785 catalytic residues [active] 863638007786 metal binding site [ion binding]; metal-binding site 863638007787 homodimer binding site [polypeptide binding]; other site 863638007788 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 863638007789 carboxyltransferase (CT) interaction site; other site 863638007790 biotinylation site [posttranslational modification]; other site 863638007791 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 863638007792 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 863638007793 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 863638007794 NlpC/P60 family; Region: NLPC_P60; pfam00877 863638007795 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 863638007796 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 863638007797 active site 863638007798 metal binding site [ion binding]; metal-binding site 863638007799 homotetramer interface [polypeptide binding]; other site 863638007800 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 863638007801 active site 863638007802 dimerization interface [polypeptide binding]; other site 863638007803 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 863638007804 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 863638007805 peptide binding site [polypeptide binding]; other site 863638007806 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 863638007807 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 863638007808 GatB domain; Region: GatB_Yqey; pfam02637 863638007809 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 863638007810 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 863638007811 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 863638007812 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 863638007813 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 863638007814 nucleotide binding pocket [chemical binding]; other site 863638007815 K-X-D-G motif; other site 863638007816 catalytic site [active] 863638007817 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 863638007818 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 863638007819 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 863638007820 Dimer interface [polypeptide binding]; other site 863638007821 BRCT sequence motif; other site 863638007822 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 863638007823 Part of AAA domain; Region: AAA_19; pfam13245 863638007824 Family description; Region: UvrD_C_2; pfam13538 863638007825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 863638007826 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 863638007827 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 863638007828 RNA binding surface [nucleotide binding]; other site 863638007829 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 863638007830 active site 863638007831 uracil binding [chemical binding]; other site 863638007832 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 863638007833 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 863638007834 N-acetyl-D-glucosamine binding site [chemical binding]; other site 863638007835 catalytic residue [active] 863638007836 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 863638007837 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 863638007838 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 863638007839 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 863638007840 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 863638007841 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 863638007842 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 863638007843 pullulanase, type I; Region: pulA_typeI; TIGR02104 863638007844 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 863638007845 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 863638007846 Ca binding site [ion binding]; other site 863638007847 active site 863638007848 catalytic site [active] 863638007849 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 863638007850 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 863638007851 active site 863638007852 dimer interface [polypeptide binding]; other site 863638007853 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 863638007854 dimer interface [polypeptide binding]; other site 863638007855 active site 863638007856 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 863638007857 Coat F domain; Region: Coat_F; pfam07875 863638007858 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 863638007859 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 863638007860 substrate binding site [chemical binding]; other site 863638007861 ATP binding site [chemical binding]; other site 863638007862 maltose phosphorylase; Provisional; Region: PRK13807 863638007863 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 863638007864 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 863638007865 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 863638007866 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 863638007867 Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353 863638007868 active site 863638007869 catalytic site [active] 863638007870 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 863638007871 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 863638007872 ATP binding site [chemical binding]; other site 863638007873 putative Mg++ binding site [ion binding]; other site 863638007874 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 863638007875 nucleotide binding region [chemical binding]; other site 863638007876 ATP-binding site [chemical binding]; other site 863638007877 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 863638007878 HRDC domain; Region: HRDC; pfam00570 863638007879 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 863638007880 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 863638007881 TAP-like protein; Region: Abhydrolase_4; pfam08386 863638007882 Putative amidase domain; Region: Amidase_6; pfam12671 863638007883 Transcriptional regulator [Transcription]; Region: LysR; COG0583 863638007884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 863638007885 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 863638007886 dimerization interface [polypeptide binding]; other site 863638007887 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 863638007888 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 863638007889 putative ligand binding site [chemical binding]; other site 863638007890 putative NAD binding site [chemical binding]; other site 863638007891 catalytic site [active] 863638007892 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 863638007893 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 863638007894 active site 863638007895 substrate binding site [chemical binding]; other site 863638007896 trimer interface [polypeptide binding]; other site 863638007897 CoA binding site [chemical binding]; other site 863638007898 Bacterial SH3 domain; Region: SH3_3; pfam08239 863638007899 Helix-turn-helix domain; Region: HTH_17; cl17695 863638007900 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 863638007901 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 863638007902 GMP synthase; Reviewed; Region: guaA; PRK00074 863638007903 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 863638007904 AMP/PPi binding site [chemical binding]; other site 863638007905 candidate oxyanion hole; other site 863638007906 catalytic triad [active] 863638007907 potential glutamine specificity residues [chemical binding]; other site 863638007908 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 863638007909 ATP Binding subdomain [chemical binding]; other site 863638007910 Ligand Binding sites [chemical binding]; other site 863638007911 Dimerization subdomain; other site 863638007912 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 863638007913 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 863638007914 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 863638007915 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 863638007916 active site 863638007917 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 863638007918 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 863638007919 FOG: CBS domain [General function prediction only]; Region: COG0517 863638007920 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 863638007921 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 863638007922 metal binding site [ion binding]; metal-binding site 863638007923 active site 863638007924 I-site; other site 863638007925 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 863638007926 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 863638007927 ring oligomerisation interface [polypeptide binding]; other site 863638007928 ATP/Mg binding site [chemical binding]; other site 863638007929 stacking interactions; other site 863638007930 hinge regions; other site 863638007931 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 863638007932 oligomerisation interface [polypeptide binding]; other site 863638007933 mobile loop; other site 863638007934 roof hairpin; other site 863638007935 Predicted membrane protein [Function unknown]; Region: COG4478 863638007936 Uncharacterized conserved protein [Function unknown]; Region: COG0398 863638007937 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 863638007938 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 863638007939 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 863638007940 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 863638007941 minor groove reading motif; other site 863638007942 helix-hairpin-helix signature motif; other site 863638007943 substrate binding pocket [chemical binding]; other site 863638007944 active site 863638007945 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 863638007946 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 863638007947 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 863638007948 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 863638007949 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 863638007950 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 863638007951 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 863638007952 Ligand binding site [chemical binding]; other site 863638007953 Electron transfer flavoprotein domain; Region: ETF; pfam01012 863638007954 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 863638007955 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 863638007956 FAD binding site [chemical binding]; other site 863638007957 homotetramer interface [polypeptide binding]; other site 863638007958 substrate binding pocket [chemical binding]; other site 863638007959 catalytic base [active] 863638007960 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 863638007961 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 863638007962 substrate binding site [chemical binding]; other site 863638007963 oxyanion hole (OAH) forming residues; other site 863638007964 trimer interface [polypeptide binding]; other site 863638007965 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 863638007966 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 863638007967 CoA binding domain; Region: CoA_binding; pfam02629 863638007968 potential frameshift: common BLAST hit: gi|337737924|ref|YP_004637371.1| ABC transporter ATPase 863638007969 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 863638007970 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 863638007971 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 863638007972 ABC transporter; Region: ABC_tran_2; pfam12848 863638007973 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 863638007974 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 863638007975 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 863638007976 glycosyltransferase, MGT family; Region: MGT; TIGR01426 863638007977 active site 863638007978 TDP-binding site; other site 863638007979 acceptor substrate-binding pocket; other site 863638007980 homodimer interface [polypeptide binding]; other site 863638007981 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 863638007982 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 863638007983 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 863638007984 ethanolamine permease; Region: 2A0305; TIGR00908 863638007985 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 863638007986 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 863638007987 Histidine kinase; Region: HisKA_2; pfam07568 863638007988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638007989 ATP binding site [chemical binding]; other site 863638007990 Mg2+ binding site [ion binding]; other site 863638007991 G-X-G motif; other site 863638007992 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 863638007993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638007994 active site 863638007995 phosphorylation site [posttranslational modification] 863638007996 intermolecular recognition site; other site 863638007997 dimerization interface [polypeptide binding]; other site 863638007998 ANTAR domain; Region: ANTAR; pfam03861 863638007999 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 863638008000 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 863638008001 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 863638008002 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 863638008003 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 863638008004 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 863638008005 dipeptidase PepV; Reviewed; Region: PRK07318 863638008006 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 863638008007 active site 863638008008 metal binding site [ion binding]; metal-binding site 863638008009 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 863638008010 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 863638008011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 863638008012 histidinol-phosphatase; Provisional; Region: PRK05588 863638008013 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 863638008014 active site 863638008015 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 863638008016 Bacterial SH3 domain; Region: SH3_3; pfam08239 863638008017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638008018 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638008019 dimer interface [polypeptide binding]; other site 863638008020 phosphorylation site [posttranslational modification] 863638008021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638008022 ATP binding site [chemical binding]; other site 863638008023 Mg2+ binding site [ion binding]; other site 863638008024 G-X-G motif; other site 863638008025 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 863638008026 FtsX-like permease family; Region: FtsX; pfam02687 863638008027 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 863638008028 FtsX-like permease family; Region: FtsX; pfam02687 863638008029 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638008030 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 863638008031 Walker A/P-loop; other site 863638008032 ATP binding site [chemical binding]; other site 863638008033 Q-loop/lid; other site 863638008034 ABC transporter signature motif; other site 863638008035 Walker B; other site 863638008036 D-loop; other site 863638008037 H-loop/switch region; other site 863638008038 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 863638008039 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 863638008040 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 863638008041 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 863638008042 Walker A/P-loop; other site 863638008043 ATP binding site [chemical binding]; other site 863638008044 Q-loop/lid; other site 863638008045 ABC transporter signature motif; other site 863638008046 Walker B; other site 863638008047 D-loop; other site 863638008048 H-loop/switch region; other site 863638008049 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638008050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638008051 active site 863638008052 phosphorylation site [posttranslational modification] 863638008053 intermolecular recognition site; other site 863638008054 dimerization interface [polypeptide binding]; other site 863638008055 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638008056 DNA binding site [nucleotide binding] 863638008057 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 863638008058 AAA domain; Region: AAA_23; pfam13476 863638008059 Walker A/P-loop; other site 863638008060 ATP binding site [chemical binding]; other site 863638008061 Q-loop/lid; other site 863638008062 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 863638008063 Cytochrome P450; Region: p450; cl12078 863638008064 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 863638008065 ABC transporter signature motif; other site 863638008066 Walker B; other site 863638008067 D-loop; other site 863638008068 H-loop/switch region; other site 863638008069 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 863638008070 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 863638008071 active site 863638008072 metal binding site [ion binding]; metal-binding site 863638008073 DNA binding site [nucleotide binding] 863638008074 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 863638008075 Uncharacterized conserved protein [Function unknown]; Region: COG2013 863638008076 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 863638008077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638008078 Coenzyme A binding pocket [chemical binding]; other site 863638008079 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 863638008080 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 863638008081 dimer interface [polypeptide binding]; other site 863638008082 motif 1; other site 863638008083 active site 863638008084 motif 2; other site 863638008085 motif 3; other site 863638008086 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 863638008087 anticodon binding site; other site 863638008088 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 863638008089 catalytic core [active] 863638008090 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 863638008091 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 863638008092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638008093 putative substrate translocation pore; other site 863638008094 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 863638008095 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638008096 dimer interface [polypeptide binding]; other site 863638008097 putative CheW interface [polypeptide binding]; other site 863638008098 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 863638008099 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638008100 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 863638008101 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638008102 dimer interface [polypeptide binding]; other site 863638008103 putative CheW interface [polypeptide binding]; other site 863638008104 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 863638008105 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 863638008106 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 863638008107 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 863638008108 active site 863638008109 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 863638008110 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 863638008111 ATP binding site [chemical binding]; other site 863638008112 Mg++ binding site [ion binding]; other site 863638008113 motif III; other site 863638008114 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 863638008115 nucleotide binding region [chemical binding]; other site 863638008116 ATP-binding site [chemical binding]; other site 863638008117 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 863638008118 RNA binding site [nucleotide binding]; other site 863638008119 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 863638008120 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 863638008121 active site 863638008122 metal binding site [ion binding]; metal-binding site 863638008123 homotetramer interface [polypeptide binding]; other site 863638008124 hybrid cluster protein; Provisional; Region: PRK05290 863638008125 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 863638008126 ACS interaction site; other site 863638008127 CODH interaction site; other site 863638008128 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 863638008129 hybrid metal cluster; other site 863638008130 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 863638008131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638008132 Coenzyme A binding pocket [chemical binding]; other site 863638008133 Predicted membrane protein [Function unknown]; Region: COG4684 863638008134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638008135 Major Facilitator Superfamily; Region: MFS_1; pfam07690 863638008136 putative substrate translocation pore; other site 863638008137 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 863638008138 putative catalytic site [active] 863638008139 putative phosphate binding site [ion binding]; other site 863638008140 putative metal binding site [ion binding]; other site 863638008141 Jacalin-like lectin domains of putative endonucleases/exonucleases/phosphatases and related proteins; Region: Jacalin_EEP; cd09615 863638008142 putative sugar binding site [chemical binding]; other site 863638008143 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 863638008144 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 863638008145 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638008146 Walker A/P-loop; other site 863638008147 ATP binding site [chemical binding]; other site 863638008148 Q-loop/lid; other site 863638008149 ABC transporter signature motif; other site 863638008150 Walker B; other site 863638008151 D-loop; other site 863638008152 H-loop/switch region; other site 863638008153 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 863638008154 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 863638008155 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 863638008156 Walker A/P-loop; other site 863638008157 ATP binding site [chemical binding]; other site 863638008158 Q-loop/lid; other site 863638008159 ABC transporter signature motif; other site 863638008160 Walker B; other site 863638008161 D-loop; other site 863638008162 H-loop/switch region; other site 863638008163 Predicted secreted protein [Function unknown]; Region: COG4086 863638008164 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 863638008165 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638008166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638008167 active site 863638008168 phosphorylation site [posttranslational modification] 863638008169 intermolecular recognition site; other site 863638008170 dimerization interface [polypeptide binding]; other site 863638008171 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638008172 DNA binding site [nucleotide binding] 863638008173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638008174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638008175 dimerization interface [polypeptide binding]; other site 863638008176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638008177 dimer interface [polypeptide binding]; other site 863638008178 phosphorylation site [posttranslational modification] 863638008179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638008180 ATP binding site [chemical binding]; other site 863638008181 Mg2+ binding site [ion binding]; other site 863638008182 G-X-G motif; other site 863638008183 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 863638008184 ApbE family; Region: ApbE; pfam02424 863638008185 4Fe-4S binding domain; Region: Fer4_5; pfam12801 863638008186 4Fe-4S binding domain; Region: Fer4_5; pfam12801 863638008187 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 863638008188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3976 863638008189 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 863638008190 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 863638008191 HAMP domain; Region: HAMP; pfam00672 863638008192 dimerization interface [polypeptide binding]; other site 863638008193 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638008194 dimer interface [polypeptide binding]; other site 863638008195 putative CheW interface [polypeptide binding]; other site 863638008196 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 863638008197 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 863638008198 ApbE family; Region: ApbE; pfam02424 863638008199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3976 863638008200 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638008201 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638008202 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 863638008203 active site 863638008204 amino acid transporter; Region: 2A0306; TIGR00909 863638008205 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 863638008206 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 863638008207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638008208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638008209 WHG domain; Region: WHG; pfam13305 863638008210 Cache domain; Region: Cache_2; pfam08269 863638008211 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 863638008212 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638008213 dimerization interface [polypeptide binding]; other site 863638008214 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638008215 dimer interface [polypeptide binding]; other site 863638008216 putative CheW interface [polypeptide binding]; other site 863638008217 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 863638008218 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 863638008219 putative active site [active] 863638008220 putative metal binding site [ion binding]; other site 863638008221 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 863638008222 catalytic residues [active] 863638008223 Rubredoxin [Energy production and conversion]; Region: COG1773 863638008224 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 863638008225 iron binding site [ion binding]; other site 863638008226 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 863638008227 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 863638008228 EamA-like transporter family; Region: EamA; pfam00892 863638008229 EamA-like transporter family; Region: EamA; pfam00892 863638008230 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 863638008231 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 863638008232 homodimer interface [polypeptide binding]; other site 863638008233 substrate-cofactor binding pocket; other site 863638008234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638008235 catalytic residue [active] 863638008236 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 863638008237 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 863638008238 Domain of unknown function DUF77; Region: DUF77; pfam01910 863638008239 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 863638008240 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 863638008241 active site 863638008242 metal binding site [ion binding]; metal-binding site 863638008243 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 863638008244 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 863638008245 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 863638008246 active site 863638008247 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 863638008248 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638008249 FeS/SAM binding site; other site 863638008250 Predicted membrane protein/domain [Function unknown]; Region: COG1714 863638008251 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 863638008252 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 863638008253 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 863638008254 putative DNA binding site [nucleotide binding]; other site 863638008255 putative Zn2+ binding site [ion binding]; other site 863638008256 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 863638008257 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638008258 FeS/SAM binding site; other site 863638008259 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 863638008260 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 863638008261 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638008262 FeS/SAM binding site; other site 863638008263 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 863638008264 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 863638008265 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 863638008266 active site 863638008267 FMN binding site [chemical binding]; other site 863638008268 substrate binding site [chemical binding]; other site 863638008269 putative catalytic residue [active] 863638008270 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 863638008271 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 863638008272 dimanganese center [ion binding]; other site 863638008273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638008274 TPR motif; other site 863638008275 Tetratricopeptide repeat; Region: TPR_12; pfam13424 863638008276 binding surface 863638008277 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 863638008278 Sulfatase; Region: Sulfatase; pfam00884 863638008279 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 863638008280 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 863638008281 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638008282 dimer interface [polypeptide binding]; other site 863638008283 putative CheW interface [polypeptide binding]; other site 863638008284 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 863638008285 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 863638008286 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 863638008287 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 863638008288 catalytic residue [active] 863638008289 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 863638008290 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 863638008291 putative active site [active] 863638008292 putative metal binding site [ion binding]; other site 863638008293 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 863638008294 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 863638008295 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 863638008296 active site 863638008297 active site 863638008298 catalytic residues [active] 863638008299 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 863638008300 Beta-lactamase; Region: Beta-lactamase; pfam00144 863638008301 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 863638008302 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 863638008303 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 863638008304 active site 863638008305 Int/Topo IB signature motif; other site 863638008306 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 863638008307 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 863638008308 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 863638008309 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 863638008310 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 863638008311 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 863638008312 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 863638008313 Cache domain; Region: Cache_1; pfam02743 863638008314 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 863638008315 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638008316 dimerization interface [polypeptide binding]; other site 863638008317 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638008318 dimer interface [polypeptide binding]; other site 863638008319 putative CheW interface [polypeptide binding]; other site 863638008320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638008321 binding surface 863638008322 TPR motif; other site 863638008323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638008324 binding surface 863638008325 TPR motif; other site 863638008326 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 863638008327 metal binding site [ion binding]; metal-binding site 863638008328 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205 863638008329 PLD-like domain; Region: PLDc_2; pfam13091 863638008330 putative homodimer interface [polypeptide binding]; other site 863638008331 putative active site [active] 863638008332 catalytic site [active] 863638008333 DEAD-like helicases superfamily; Region: DEXDc; smart00487 863638008334 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 863638008335 ATP binding site [chemical binding]; other site 863638008336 putative Mg++ binding site [ion binding]; other site 863638008337 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 863638008338 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 863638008339 nucleotide binding region [chemical binding]; other site 863638008340 ATP-binding site [chemical binding]; other site 863638008341 hypothetical protein; Validated; Region: PRK00124 863638008342 DJ-1 family protein; Region: not_thiJ; TIGR01383 863638008343 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 863638008344 conserved cys residue [active] 863638008345 Methyltransferase domain; Region: Methyltransf_23; pfam13489 863638008346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638008347 S-adenosylmethionine binding site [chemical binding]; other site 863638008348 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 863638008349 active site 863638008350 8-oxo-dGMP binding site [chemical binding]; other site 863638008351 nudix motif; other site 863638008352 metal binding site [ion binding]; metal-binding site 863638008353 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 863638008354 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 863638008355 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 863638008356 aspartate aminotransferase; Provisional; Region: PRK06836 863638008357 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 863638008358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638008359 homodimer interface [polypeptide binding]; other site 863638008360 catalytic residue [active] 863638008361 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 863638008362 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 863638008363 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 863638008364 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 863638008365 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 863638008366 fructuronate transporter; Provisional; Region: PRK10034; cl15264 863638008367 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 863638008368 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 863638008369 intersubunit interface [polypeptide binding]; other site 863638008370 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 863638008371 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638008372 Zn2+ binding site [ion binding]; other site 863638008373 Mg2+ binding site [ion binding]; other site 863638008374 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638008375 Zn2+ binding site [ion binding]; other site 863638008376 Mg2+ binding site [ion binding]; other site 863638008377 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 863638008378 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 863638008379 Glycoprotease family; Region: Peptidase_M22; pfam00814 863638008380 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 863638008381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638008382 Coenzyme A binding pocket [chemical binding]; other site 863638008383 Predicted membrane protein [Function unknown]; Region: COG3601 863638008384 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 863638008385 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 863638008386 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 863638008387 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 863638008388 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 863638008389 RNA binding site [nucleotide binding]; other site 863638008390 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 863638008391 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 863638008392 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 863638008393 metal binding site [ion binding]; metal-binding site 863638008394 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 863638008395 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 863638008396 dimer interface [polypeptide binding]; other site 863638008397 active site 863638008398 peptide chain release factor 2; Provisional; Region: PRK05589 863638008399 This domain is found in peptide chain release factors; Region: PCRF; smart00937 863638008400 RF-1 domain; Region: RF-1; pfam00472 863638008401 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 863638008402 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 863638008403 SEC-C motif; Region: SEC-C; pfam02810 863638008404 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 863638008405 30S subunit binding site; other site 863638008406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638008407 dimer interface [polypeptide binding]; other site 863638008408 conserved gate region; other site 863638008409 putative PBP binding loops; other site 863638008410 ABC-ATPase subunit interface; other site 863638008411 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 863638008412 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 863638008413 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 863638008414 Walker A/P-loop; other site 863638008415 ATP binding site [chemical binding]; other site 863638008416 Q-loop/lid; other site 863638008417 ABC transporter signature motif; other site 863638008418 Walker B; other site 863638008419 D-loop; other site 863638008420 H-loop/switch region; other site 863638008421 FOG: CBS domain [General function prediction only]; Region: COG0517 863638008422 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 863638008423 Predicted transcriptional regulators [Transcription]; Region: COG1725 863638008424 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 863638008425 DNA-binding site [nucleotide binding]; DNA binding site 863638008426 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 863638008427 TrkA-C domain; Region: TrkA_C; pfam02080 863638008428 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 863638008429 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 863638008430 active site 863638008431 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 863638008432 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 863638008433 AAA domain; Region: AAA_30; pfam13604 863638008434 Family description; Region: UvrD_C_2; pfam13538 863638008435 S-adenosylmethionine synthetase; Validated; Region: PRK05250 863638008436 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 863638008437 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 863638008438 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 863638008439 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 863638008440 rod shape-determining protein Mbl; Provisional; Region: PRK13928 863638008441 MreB and similar proteins; Region: MreB_like; cd10225 863638008442 nucleotide binding site [chemical binding]; other site 863638008443 Mg binding site [ion binding]; other site 863638008444 putative protofilament interaction site [polypeptide binding]; other site 863638008445 RodZ interaction site [polypeptide binding]; other site 863638008446 Stage III sporulation protein D; Region: SpoIIID; pfam12116 863638008447 Peptidase family M23; Region: Peptidase_M23; pfam01551 863638008448 stage II sporulation protein D; Region: spore_II_D; TIGR02870 863638008449 Stage II sporulation protein; Region: SpoIID; pfam08486 863638008450 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 863638008451 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 863638008452 hinge; other site 863638008453 active site 863638008454 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 863638008455 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450 863638008456 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 863638008457 gamma subunit interface [polypeptide binding]; other site 863638008458 epsilon subunit interface [polypeptide binding]; other site 863638008459 LBP interface [polypeptide binding]; other site 863638008460 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 863638008461 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 863638008462 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 863638008463 alpha subunit interaction interface [polypeptide binding]; other site 863638008464 Walker A motif; other site 863638008465 ATP binding site [chemical binding]; other site 863638008466 Walker B motif; other site 863638008467 inhibitor binding site; inhibition site 863638008468 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 863638008469 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 863638008470 core domain interface [polypeptide binding]; other site 863638008471 delta subunit interface [polypeptide binding]; other site 863638008472 epsilon subunit interface [polypeptide binding]; other site 863638008473 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 863638008474 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 863638008475 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 863638008476 beta subunit interaction interface [polypeptide binding]; other site 863638008477 Walker A motif; other site 863638008478 ATP binding site [chemical binding]; other site 863638008479 Walker B motif; other site 863638008480 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 863638008481 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712 863638008482 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 863638008483 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 863638008484 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 863638008485 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 863638008486 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 863638008487 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 863638008488 putative acyltransferase; Provisional; Region: PRK05790 863638008489 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 863638008490 dimer interface [polypeptide binding]; other site 863638008491 active site 863638008492 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 863638008493 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 863638008494 active site 863638008495 homodimer interface [polypeptide binding]; other site 863638008496 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 863638008497 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 863638008498 Mg++ binding site [ion binding]; other site 863638008499 putative catalytic motif [active] 863638008500 substrate binding site [chemical binding]; other site 863638008501 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 863638008502 catalytic motif [active] 863638008503 Zn binding site [ion binding]; other site 863638008504 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638008505 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 863638008506 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 863638008507 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 863638008508 ABC-ATPase subunit interface; other site 863638008509 dimer interface [polypeptide binding]; other site 863638008510 putative PBP binding regions; other site 863638008511 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 863638008512 active site 863638008513 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 863638008514 Low molecular weight phosphatase family; Region: LMWPc; cd00115 863638008515 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 863638008516 active site 863638008517 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 863638008518 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 863638008519 peptide chain release factor 1; Validated; Region: prfA; PRK00591 863638008520 This domain is found in peptide chain release factors; Region: PCRF; smart00937 863638008521 RF-1 domain; Region: RF-1; pfam00472 863638008522 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 863638008523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638008524 S-adenosylmethionine binding site [chemical binding]; other site 863638008525 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 863638008526 thymidine kinase; Provisional; Region: PRK04296 863638008527 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 863638008528 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 863638008529 transcription termination factor Rho; Provisional; Region: PRK12608 863638008530 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 863638008531 RNA binding site [nucleotide binding]; other site 863638008532 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 863638008533 multimer interface [polypeptide binding]; other site 863638008534 Walker A motif; other site 863638008535 ATP binding site [chemical binding]; other site 863638008536 Walker B motif; other site 863638008537 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 863638008538 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 863638008539 active site 863638008540 catalytic site [active] 863638008541 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 863638008542 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 863638008543 CTP synthetase; Validated; Region: pyrG; PRK05380 863638008544 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 863638008545 Catalytic site [active] 863638008546 active site 863638008547 UTP binding site [chemical binding]; other site 863638008548 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 863638008549 active site 863638008550 putative oxyanion hole; other site 863638008551 catalytic triad [active] 863638008552 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 863638008553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 863638008554 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 863638008555 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 863638008556 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 863638008557 germination protein YpeB; Region: spore_YpeB; TIGR02889 863638008558 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 863638008559 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 863638008560 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 863638008561 stage II sporulation protein R; Region: spore_II_R; TIGR02837 863638008562 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 863638008563 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 863638008564 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 863638008565 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 863638008566 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 863638008567 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 863638008568 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 863638008569 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 863638008570 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 863638008571 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 863638008572 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 863638008573 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 863638008574 YabG peptidase U57; Region: Peptidase_U57; pfam05582 863638008575 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 863638008576 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 863638008577 active site 863638008578 ATP binding site [chemical binding]; other site 863638008579 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 863638008580 substrate binding site [chemical binding]; other site 863638008581 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 863638008582 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638008583 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 863638008584 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 863638008585 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 863638008586 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 863638008587 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 863638008588 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 863638008589 substrate binding site [chemical binding]; other site 863638008590 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638008591 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 863638008592 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 863638008593 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 863638008594 oligomerization interface [polypeptide binding]; other site 863638008595 active site 863638008596 metal binding site [ion binding]; metal-binding site 863638008597 Pantoate-beta-alanine ligase; Region: PanC; cd00560 863638008598 pantoate--beta-alanine ligase; Region: panC; TIGR00018 863638008599 active site 863638008600 ATP-binding site [chemical binding]; other site 863638008601 pantoate-binding site; other site 863638008602 HXXH motif; other site 863638008603 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 863638008604 tetramerization interface [polypeptide binding]; other site 863638008605 active site 863638008606 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 863638008607 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 863638008608 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 863638008609 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 863638008610 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 863638008611 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 863638008612 thiamine phosphate binding site [chemical binding]; other site 863638008613 active site 863638008614 pyrophosphate binding site [ion binding]; other site 863638008615 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 863638008616 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638008617 FeS/SAM binding site; other site 863638008618 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 863638008619 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 863638008620 ThiS interaction site; other site 863638008621 putative active site [active] 863638008622 tetramer interface [polypeptide binding]; other site 863638008623 ThiS-like ubiquitin; Region: ThiS-like; pfam14453 863638008624 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 863638008625 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 863638008626 putative ATP binding site [chemical binding]; other site 863638008627 putative substrate interface [chemical binding]; other site 863638008628 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 863638008629 thiS-thiF/thiG interaction site; other site 863638008630 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 863638008631 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638008632 Zn2+ binding site [ion binding]; other site 863638008633 Mg2+ binding site [ion binding]; other site 863638008634 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 863638008635 dihydropteroate synthase; Region: DHPS; TIGR01496 863638008636 substrate binding pocket [chemical binding]; other site 863638008637 dimer interface [polypeptide binding]; other site 863638008638 inhibitor binding site; inhibition site 863638008639 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 863638008640 homooctamer interface [polypeptide binding]; other site 863638008641 active site 863638008642 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 863638008643 catalytic center binding site [active] 863638008644 ATP binding site [chemical binding]; other site 863638008645 Predicted membrane protein [Function unknown]; Region: COG3859 863638008646 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 863638008647 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 863638008648 ABC-2 type transporter; Region: ABC2_membrane; cl17235 863638008649 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 863638008650 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 863638008651 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 863638008652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638008653 Walker A/P-loop; other site 863638008654 ATP binding site [chemical binding]; other site 863638008655 Q-loop/lid; other site 863638008656 ABC transporter signature motif; other site 863638008657 Walker B; other site 863638008658 D-loop; other site 863638008659 H-loop/switch region; other site 863638008660 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 863638008661 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 863638008662 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 863638008663 putative FMN binding site [chemical binding]; other site 863638008664 Predicted transcriptional regulators [Transcription]; Region: COG1733 863638008665 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 863638008666 dimerization interface [polypeptide binding]; other site 863638008667 putative DNA binding site [nucleotide binding]; other site 863638008668 putative Zn2+ binding site [ion binding]; other site 863638008669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638008670 Coenzyme A binding pocket [chemical binding]; other site 863638008671 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 863638008672 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 863638008673 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 863638008674 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 863638008675 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 863638008676 This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins; Region: LNS2; smart00775 863638008677 LNS2 (Lipin/Ned1/Smp2); Region: LNS2; pfam08235 863638008678 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 863638008679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638008680 active site 863638008681 phosphorylation site [posttranslational modification] 863638008682 intermolecular recognition site; other site 863638008683 dimerization interface [polypeptide binding]; other site 863638008684 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 863638008685 DNA binding residues [nucleotide binding] 863638008686 dimerization interface [polypeptide binding]; other site 863638008687 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 863638008688 Histidine kinase; Region: HisKA_3; pfam07730 863638008689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638008690 ATP binding site [chemical binding]; other site 863638008691 Mg2+ binding site [ion binding]; other site 863638008692 G-X-G motif; other site 863638008693 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638008694 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 863638008695 active site 863638008696 motif I; other site 863638008697 motif II; other site 863638008698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 863638008699 S-ribosylhomocysteinase; Provisional; Region: PRK02260 863638008700 Family description; Region: VCBS; pfam13517 863638008701 Family description; Region: VCBS; pfam13517 863638008702 Family description; Region: VCBS; pfam13517 863638008703 Family description; Region: VCBS; pfam13517 863638008704 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 863638008705 NlpC/P60 family; Region: NLPC_P60; pfam00877 863638008706 Family description; Region: VCBS; pfam13517 863638008707 Family description; Region: VCBS; pfam13517 863638008708 Family description; Region: VCBS; pfam13517 863638008709 Family description; Region: VCBS; pfam13517 863638008710 Family description; Region: VCBS; pfam13517 863638008711 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 863638008712 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 863638008713 NlpC/P60 family; Region: NLPC_P60; pfam00877 863638008714 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 863638008715 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 863638008716 putative ligand binding site [chemical binding]; other site 863638008717 putative NAD binding site [chemical binding]; other site 863638008718 catalytic site [active] 863638008719 DNA topoisomerase III; Provisional; Region: PRK07726 863638008720 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 863638008721 active site 863638008722 putative interdomain interaction site [polypeptide binding]; other site 863638008723 putative metal-binding site [ion binding]; other site 863638008724 putative nucleotide binding site [chemical binding]; other site 863638008725 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 863638008726 domain I; other site 863638008727 DNA binding groove [nucleotide binding] 863638008728 phosphate binding site [ion binding]; other site 863638008729 domain II; other site 863638008730 domain III; other site 863638008731 nucleotide binding site [chemical binding]; other site 863638008732 catalytic site [active] 863638008733 domain IV; other site 863638008734 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 863638008735 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 863638008736 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 863638008737 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 863638008738 ABC transporter; Region: ABC_tran_2; pfam12848 863638008739 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 863638008740 Predicted permeases [General function prediction only]; Region: COG0679 863638008741 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 863638008742 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 863638008743 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 863638008744 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 863638008745 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 863638008746 putative substrate binding site [chemical binding]; other site 863638008747 putative ATP binding site [chemical binding]; other site 863638008748 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 863638008749 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 863638008750 intersubunit interface [polypeptide binding]; other site 863638008751 active site 863638008752 zinc binding site [ion binding]; other site 863638008753 Na+ binding site [ion binding]; other site 863638008754 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 863638008755 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 863638008756 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 863638008757 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 863638008758 putative DNA binding site [nucleotide binding]; other site 863638008759 putative Zn2+ binding site [ion binding]; other site 863638008760 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 863638008761 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 863638008762 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 863638008763 Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414 863638008764 active site 863638008765 P-loop; other site 863638008766 phosphorylation site [posttranslational modification] 863638008767 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 863638008768 active site 863638008769 phosphorylation site [posttranslational modification] 863638008770 galactokinase; Provisional; Region: PRK05322 863638008771 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 863638008772 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 863638008773 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 863638008774 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 863638008775 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 863638008776 NAD binding site [chemical binding]; other site 863638008777 homodimer interface [polypeptide binding]; other site 863638008778 active site 863638008779 substrate binding site [chemical binding]; other site 863638008780 Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468 863638008781 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 863638008782 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 863638008783 Transcriptional regulators [Transcription]; Region: PurR; COG1609 863638008784 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 863638008785 DNA binding site [nucleotide binding] 863638008786 domain linker motif; other site 863638008787 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 863638008788 dimerization interface [polypeptide binding]; other site 863638008789 ligand binding site [chemical binding]; other site 863638008790 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 863638008791 beta-galactosidase; Region: BGL; TIGR03356 863638008792 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 863638008793 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 863638008794 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 863638008795 active site 863638008796 P-loop; other site 863638008797 phosphorylation site [posttranslational modification] 863638008798 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 863638008799 methionine cluster; other site 863638008800 active site 863638008801 phosphorylation site [posttranslational modification] 863638008802 metal binding site [ion binding]; metal-binding site 863638008803 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 863638008804 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 863638008805 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 863638008806 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 863638008807 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 863638008808 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 863638008809 Substrate binding site; other site 863638008810 Cupin domain; Region: Cupin_2; cl17218 863638008811 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 863638008812 active site 863638008813 DNA binding site [nucleotide binding] 863638008814 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 863638008815 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 863638008816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638008817 homodimer interface [polypeptide binding]; other site 863638008818 catalytic residue [active] 863638008819 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 863638008820 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 863638008821 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 863638008822 Ligand Binding Site [chemical binding]; other site 863638008823 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 863638008824 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 863638008825 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 863638008826 catalytic residue [active] 863638008827 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 863638008828 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 863638008829 active site 863638008830 intersubunit interface [polypeptide binding]; other site 863638008831 catalytic residue [active] 863638008832 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 863638008833 Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729 863638008834 Peptidase family U32; Region: Peptidase_U32; pfam01136 863638008835 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 863638008836 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 863638008837 GatB domain; Region: GatB_Yqey; pfam02637 863638008838 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 863638008839 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 863638008840 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 863638008841 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 863638008842 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 863638008843 Dimer interface [polypeptide binding]; other site 863638008844 anticodon binding site; other site 863638008845 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 863638008846 homodimer interface [polypeptide binding]; other site 863638008847 motif 1; other site 863638008848 motif 2; other site 863638008849 active site 863638008850 motif 3; other site 863638008851 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 863638008852 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 863638008853 active site 863638008854 Substrate binding site; other site 863638008855 Mg++ binding site; other site 863638008856 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 863638008857 putative trimer interface [polypeptide binding]; other site 863638008858 putative CoA binding site [chemical binding]; other site 863638008859 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 863638008860 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 863638008861 active site 863638008862 substrate binding site [chemical binding]; other site 863638008863 metal binding site [ion binding]; metal-binding site 863638008864 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 863638008865 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 863638008866 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 863638008867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638008868 S-adenosylmethionine binding site [chemical binding]; other site 863638008869 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 863638008870 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 863638008871 putative active site [active] 863638008872 putative metal binding site [ion binding]; other site 863638008873 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 863638008874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 863638008875 Domain of unknown function (DUF348); Region: DUF348; pfam03990 863638008876 Domain of unknown function (DUF348); Region: DUF348; pfam03990 863638008877 G5 domain; Region: G5; pfam07501 863638008878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 863638008879 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 863638008880 active site 863638008881 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 863638008882 DNA-binding site [nucleotide binding]; DNA binding site 863638008883 RNA-binding motif; other site 863638008884 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 863638008885 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 863638008886 active site 863638008887 HIGH motif; other site 863638008888 KMSKS motif; other site 863638008889 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 863638008890 tRNA binding surface [nucleotide binding]; other site 863638008891 anticodon binding site; other site 863638008892 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 863638008893 dimer interface [polypeptide binding]; other site 863638008894 putative tRNA-binding site [nucleotide binding]; other site 863638008895 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 863638008896 classical (c) SDRs; Region: SDR_c; cd05233 863638008897 NAD(P) binding site [chemical binding]; other site 863638008898 active site 863638008899 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 863638008900 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 863638008901 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 863638008902 HPr interaction site; other site 863638008903 glycerol kinase (GK) interaction site [polypeptide binding]; other site 863638008904 active site 863638008905 phosphorylation site [posttranslational modification] 863638008906 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 863638008907 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 863638008908 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 863638008909 ATP binding site [chemical binding]; other site 863638008910 putative Mg++ binding site [ion binding]; other site 863638008911 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 863638008912 nucleotide binding region [chemical binding]; other site 863638008913 ATP-binding site [chemical binding]; other site 863638008914 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 863638008915 Fe-S cluster binding site [ion binding]; other site 863638008916 active site 863638008917 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638008918 binding surface 863638008919 TPR repeat; Region: TPR_11; pfam13414 863638008920 TPR motif; other site 863638008921 TPR repeat; Region: TPR_11; pfam13414 863638008922 TPR repeat; Region: TPR_11; pfam13414 863638008923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638008924 binding surface 863638008925 TPR motif; other site 863638008926 TPR repeat; Region: TPR_11; pfam13414 863638008927 TPR repeat; Region: TPR_11; pfam13414 863638008928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638008929 binding surface 863638008930 TPR motif; other site 863638008931 TPR repeat; Region: TPR_11; pfam13414 863638008932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3877 863638008933 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 863638008934 Uncharacterized conserved protein [Function unknown]; Region: COG1633 863638008935 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 863638008936 dinuclear metal binding motif [ion binding]; other site 863638008937 thymidylate synthase; Reviewed; Region: thyA; PRK01827 863638008938 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 863638008939 dimerization interface [polypeptide binding]; other site 863638008940 active site 863638008941 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 863638008942 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 863638008943 folate binding site [chemical binding]; other site 863638008944 NADP+ binding site [chemical binding]; other site 863638008945 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 863638008946 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 863638008947 active site 863638008948 purine riboside binding site [chemical binding]; other site 863638008949 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 863638008950 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 863638008951 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 863638008952 Peptidase M16C associated; Region: M16C_assoc; pfam08367 863638008953 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 863638008954 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 863638008955 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 863638008956 ABC transporter; Region: ABC_tran_2; pfam12848 863638008957 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 863638008958 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 863638008959 FOG: CBS domain [General function prediction only]; Region: COG0517 863638008960 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 863638008961 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 863638008962 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 863638008963 NodB motif; other site 863638008964 active site 863638008965 catalytic site [active] 863638008966 Cd binding site [ion binding]; other site 863638008967 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 863638008968 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 863638008969 ATP binding site [chemical binding]; other site 863638008970 Mg++ binding site [ion binding]; other site 863638008971 motif III; other site 863638008972 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 863638008973 nucleotide binding region [chemical binding]; other site 863638008974 ATP-binding site [chemical binding]; other site 863638008975 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 863638008976 RNA binding site [nucleotide binding]; other site 863638008977 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 863638008978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638008979 Walker A/P-loop; other site 863638008980 ATP binding site [chemical binding]; other site 863638008981 Q-loop/lid; other site 863638008982 ABC transporter signature motif; other site 863638008983 Walker B; other site 863638008984 D-loop; other site 863638008985 H-loop/switch region; other site 863638008986 ABC transporter; Region: ABC_tran_2; pfam12848 863638008987 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 863638008988 Uncharacterized conserved protein [Function unknown]; Region: COG5482 863638008989 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 863638008990 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 863638008991 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638008992 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 863638008993 Predicted integral membrane protein [Function unknown]; Region: COG0392 863638008994 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 863638008995 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 863638008996 NodB motif; other site 863638008997 active site 863638008998 catalytic site [active] 863638008999 Zn binding site [ion binding]; other site 863638009000 Rubrerythrin [Energy production and conversion]; Region: COG1592 863638009001 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 863638009002 binuclear metal center [ion binding]; other site 863638009003 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 863638009004 iron binding site [ion binding]; other site 863638009005 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 863638009006 metal binding site [ion binding]; metal-binding site 863638009007 active site 863638009008 I-site; other site 863638009009 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 863638009010 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 863638009011 heterotetramer interface [polypeptide binding]; other site 863638009012 active site pocket [active] 863638009013 cleavage site 863638009014 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 863638009015 catalytic core [active] 863638009016 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 863638009017 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 863638009018 active site 863638009019 catalytic triad [active] 863638009020 oxyanion hole [active] 863638009021 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 863638009022 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 863638009023 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 863638009024 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 863638009025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638009026 Walker A/P-loop; other site 863638009027 ATP binding site [chemical binding]; other site 863638009028 Q-loop/lid; other site 863638009029 ABC transporter signature motif; other site 863638009030 Walker B; other site 863638009031 D-loop; other site 863638009032 H-loop/switch region; other site 863638009033 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 863638009034 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 863638009035 putative active site [active] 863638009036 putative metal binding site [ion binding]; other site 863638009037 CAAX protease self-immunity; Region: Abi; pfam02517 863638009038 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 863638009039 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 863638009040 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 863638009041 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 863638009042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638009043 homodimer interface [polypeptide binding]; other site 863638009044 catalytic residue [active] 863638009045 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 863638009046 active site 863638009047 catalytic residues [active] 863638009048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 863638009049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 863638009050 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 863638009051 MutS domain III; Region: MutS_III; pfam05192 863638009052 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 863638009053 Walker A/P-loop; other site 863638009054 ATP binding site [chemical binding]; other site 863638009055 Q-loop/lid; other site 863638009056 ABC transporter signature motif; other site 863638009057 Walker B; other site 863638009058 D-loop; other site 863638009059 H-loop/switch region; other site 863638009060 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 863638009061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638009062 active site 863638009063 motif I; other site 863638009064 motif II; other site 863638009065 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638009066 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 863638009067 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 863638009068 AAA domain; Region: AAA_12; pfam13087 863638009069 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 863638009070 putative active site [active] 863638009071 Transcriptional regulators [Transcription]; Region: PurR; COG1609 863638009072 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 863638009073 DNA binding site [nucleotide binding] 863638009074 domain linker motif; other site 863638009075 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 863638009076 dimerization interface [polypeptide binding]; other site 863638009077 ligand binding site [chemical binding]; other site 863638009078 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 863638009079 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 863638009080 HIGH motif; other site 863638009081 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 863638009082 active site 863638009083 KMSKS motif; other site 863638009084 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 863638009085 tRNA binding surface [nucleotide binding]; other site 863638009086 anticodon binding site; other site 863638009087 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 863638009088 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 863638009089 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 863638009090 Acyltransferase family; Region: Acyl_transf_3; pfam01757 863638009091 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 863638009092 Acyltransferase family; Region: Acyl_transf_3; pfam01757 863638009093 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 863638009094 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 863638009095 Chain length determinant protein; Region: Wzz; cl15801 863638009096 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 863638009097 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 863638009098 Transcriptional regulator [Transcription]; Region: LytR; COG1316 863638009099 integral membrane protein MviN; Region: mviN; TIGR01695 863638009100 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 863638009101 O-Antigen ligase; Region: Wzy_C; pfam04932 863638009102 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638009103 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 863638009104 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 863638009105 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 863638009106 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 863638009107 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 863638009108 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 863638009109 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638009110 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 863638009111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638009112 active site 863638009113 motif I; other site 863638009114 motif II; other site 863638009115 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 863638009116 active site 863638009117 dimer interface [polypeptide binding]; other site 863638009118 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 863638009119 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 863638009120 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 863638009121 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 863638009122 Substrate binding site; other site 863638009123 Mg++ binding site; other site 863638009124 metal-binding site 863638009125 Mg++ binding site; other site 863638009126 metal-binding site 863638009127 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 863638009128 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 863638009129 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 863638009130 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 863638009131 Substrate binding site; other site 863638009132 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 863638009133 Bacterial sugar transferase; Region: Bac_transf; pfam02397 863638009134 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 863638009135 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 863638009136 Chain length determinant protein; Region: Wzz; cl15801 863638009137 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 863638009138 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 863638009139 Transcriptional regulator [Transcription]; Region: LytR; COG1316 863638009140 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 863638009141 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 863638009142 active site 863638009143 homodimer interface [polypeptide binding]; other site 863638009144 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 863638009145 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 863638009146 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 863638009147 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638009148 putative homodimer interface [polypeptide binding]; other site 863638009149 O-Antigen ligase; Region: Wzy_C; pfam04932 863638009150 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638009151 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 863638009152 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 863638009153 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 863638009154 Probable Catalytic site; other site 863638009155 metal-binding site 863638009156 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638009157 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 863638009158 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638009159 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 863638009160 putative ADP-binding pocket [chemical binding]; other site 863638009161 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 863638009162 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 863638009163 Substrate binding site; other site 863638009164 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 863638009165 Bacterial sugar transferase; Region: Bac_transf; pfam02397 863638009166 Predicted integral membrane protein [Function unknown]; Region: COG5652 863638009167 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 863638009168 nucleotide binding site [chemical binding]; other site 863638009169 Acetokinase family; Region: Acetate_kinase; cl17229 863638009170 phosphate butyryltransferase; Validated; Region: PRK05805 863638009171 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 863638009172 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 863638009173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 863638009174 YbbR-like protein; Region: YbbR; pfam07949 863638009175 Uncharacterized conserved protein [Function unknown]; Region: COG1624 863638009176 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 863638009177 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 863638009178 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 863638009179 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 863638009180 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 863638009181 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 863638009182 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 863638009183 catalytic residues [active] 863638009184 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 863638009185 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638009186 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638009187 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638009188 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 863638009189 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638009190 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638009191 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 863638009192 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 863638009193 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 863638009194 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 863638009195 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 863638009196 dimerization domain swap beta strand [polypeptide binding]; other site 863638009197 regulatory protein interface [polypeptide binding]; other site 863638009198 active site 863638009199 regulatory phosphorylation site [posttranslational modification]; other site 863638009200 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 863638009201 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 863638009202 putative active site [active] 863638009203 heme pocket [chemical binding]; other site 863638009204 PAS domain; Region: PAS; smart00091 863638009205 putative active site [active] 863638009206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638009207 Walker A motif; other site 863638009208 ATP binding site [chemical binding]; other site 863638009209 Walker B motif; other site 863638009210 arginine finger; other site 863638009211 fumarate hydratase; Provisional; Region: PRK06842 863638009212 fumarate hydratase; Provisional; Region: PRK06246 863638009213 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 863638009214 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 863638009215 active site 863638009216 metal binding site [ion binding]; metal-binding site 863638009217 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 863638009218 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 863638009219 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 863638009220 dimer interface [polypeptide binding]; other site 863638009221 substrate binding site [chemical binding]; other site 863638009222 ATP binding site [chemical binding]; other site 863638009223 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 863638009224 substrate binding site [chemical binding]; other site 863638009225 multimerization interface [polypeptide binding]; other site 863638009226 ATP binding site [chemical binding]; other site 863638009227 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 863638009228 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 863638009229 23S rRNA interface [nucleotide binding]; other site 863638009230 L3 interface [polypeptide binding]; other site 863638009231 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 863638009232 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 863638009233 dimerization interface 3.5A [polypeptide binding]; other site 863638009234 active site 863638009235 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 863638009236 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 863638009237 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 863638009238 Walker A/P-loop; other site 863638009239 ATP binding site [chemical binding]; other site 863638009240 Q-loop/lid; other site 863638009241 ABC transporter signature motif; other site 863638009242 Walker B; other site 863638009243 D-loop; other site 863638009244 H-loop/switch region; other site 863638009245 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 863638009246 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 863638009247 Walker A/P-loop; other site 863638009248 ATP binding site [chemical binding]; other site 863638009249 Q-loop/lid; other site 863638009250 ABC transporter signature motif; other site 863638009251 Walker B; other site 863638009252 D-loop; other site 863638009253 H-loop/switch region; other site 863638009254 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 863638009255 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 863638009256 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 863638009257 alphaNTD homodimer interface [polypeptide binding]; other site 863638009258 alphaNTD - beta interaction site [polypeptide binding]; other site 863638009259 alphaNTD - beta' interaction site [polypeptide binding]; other site 863638009260 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 863638009261 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 863638009262 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 863638009263 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 863638009264 RNA binding surface [nucleotide binding]; other site 863638009265 30S ribosomal protein S11; Validated; Region: PRK05309 863638009266 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 863638009267 30S ribosomal protein S13; Region: bact_S13; TIGR03631 863638009268 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 863638009269 rRNA binding site [nucleotide binding]; other site 863638009270 predicted 30S ribosome binding site; other site 863638009271 Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]; Region: RPL14A; COG2163 863638009272 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 863638009273 RNA binding site [nucleotide binding]; other site 863638009274 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 863638009275 active site 863638009276 adenylate kinase; Reviewed; Region: adk; PRK00279 863638009277 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 863638009278 AMP-binding site [chemical binding]; other site 863638009279 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 863638009280 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 863638009281 SecY translocase; Region: SecY; pfam00344 863638009282 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 863638009283 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 863638009284 23S rRNA binding site [nucleotide binding]; other site 863638009285 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 863638009286 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 863638009287 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 863638009288 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 863638009289 5S rRNA interface [nucleotide binding]; other site 863638009290 L27 interface [polypeptide binding]; other site 863638009291 23S rRNA interface [nucleotide binding]; other site 863638009292 L5 interface [polypeptide binding]; other site 863638009293 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 863638009294 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 863638009295 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 863638009296 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 863638009297 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 863638009298 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 863638009299 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 863638009300 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 863638009301 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 863638009302 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 863638009303 RNA binding site [nucleotide binding]; other site 863638009304 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 863638009305 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 863638009306 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 863638009307 23S rRNA interface [nucleotide binding]; other site 863638009308 putative translocon interaction site; other site 863638009309 signal recognition particle (SRP54) interaction site; other site 863638009310 L23 interface [polypeptide binding]; other site 863638009311 trigger factor interaction site; other site 863638009312 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 863638009313 23S rRNA interface [nucleotide binding]; other site 863638009314 5S rRNA interface [nucleotide binding]; other site 863638009315 putative antibiotic binding site [chemical binding]; other site 863638009316 L25 interface [polypeptide binding]; other site 863638009317 L27 interface [polypeptide binding]; other site 863638009318 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 863638009319 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 863638009320 G-X-X-G motif; other site 863638009321 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 863638009322 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 863638009323 putative translocon binding site; other site 863638009324 protein-rRNA interface [nucleotide binding]; other site 863638009325 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 863638009326 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 863638009327 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 863638009328 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 863638009329 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 863638009330 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 863638009331 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 863638009332 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 863638009333 elongation factor Tu; Reviewed; Region: PRK00049 863638009334 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 863638009335 G1 box; other site 863638009336 GEF interaction site [polypeptide binding]; other site 863638009337 GTP/Mg2+ binding site [chemical binding]; other site 863638009338 Switch I region; other site 863638009339 G2 box; other site 863638009340 G3 box; other site 863638009341 Switch II region; other site 863638009342 G4 box; other site 863638009343 G5 box; other site 863638009344 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 863638009345 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 863638009346 Antibiotic Binding Site [chemical binding]; other site 863638009347 elongation factor G; Reviewed; Region: PRK00007 863638009348 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 863638009349 G1 box; other site 863638009350 putative GEF interaction site [polypeptide binding]; other site 863638009351 GTP/Mg2+ binding site [chemical binding]; other site 863638009352 Switch I region; other site 863638009353 G2 box; other site 863638009354 G3 box; other site 863638009355 Switch II region; other site 863638009356 G4 box; other site 863638009357 G5 box; other site 863638009358 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 863638009359 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 863638009360 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 863638009361 30S ribosomal protein S7; Validated; Region: PRK05302 863638009362 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 863638009363 S17 interaction site [polypeptide binding]; other site 863638009364 S8 interaction site; other site 863638009365 16S rRNA interaction site [nucleotide binding]; other site 863638009366 streptomycin interaction site [chemical binding]; other site 863638009367 23S rRNA interaction site [nucleotide binding]; other site 863638009368 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 863638009369 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 863638009370 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 863638009371 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 863638009372 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 863638009373 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 863638009374 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 863638009375 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 863638009376 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 863638009377 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 863638009378 G-loop; other site 863638009379 DNA binding site [nucleotide binding] 863638009380 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 863638009381 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 863638009382 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 863638009383 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 863638009384 RPB1 interaction site [polypeptide binding]; other site 863638009385 RPB10 interaction site [polypeptide binding]; other site 863638009386 RPB11 interaction site [polypeptide binding]; other site 863638009387 RPB3 interaction site [polypeptide binding]; other site 863638009388 RPB12 interaction site [polypeptide binding]; other site 863638009389 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 863638009390 core dimer interface [polypeptide binding]; other site 863638009391 peripheral dimer interface [polypeptide binding]; other site 863638009392 L10 interface [polypeptide binding]; other site 863638009393 L11 interface [polypeptide binding]; other site 863638009394 putative EF-Tu interaction site [polypeptide binding]; other site 863638009395 putative EF-G interaction site [polypeptide binding]; other site 863638009396 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 863638009397 23S rRNA interface [nucleotide binding]; other site 863638009398 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 863638009399 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 863638009400 mRNA/rRNA interface [nucleotide binding]; other site 863638009401 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 863638009402 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 863638009403 23S rRNA interface [nucleotide binding]; other site 863638009404 L7/L12 interface [polypeptide binding]; other site 863638009405 putative thiostrepton binding site; other site 863638009406 L25 interface [polypeptide binding]; other site 863638009407 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 863638009408 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 863638009409 putative homodimer interface [polypeptide binding]; other site 863638009410 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 863638009411 heterodimer interface [polypeptide binding]; other site 863638009412 homodimer interface [polypeptide binding]; other site 863638009413 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 863638009414 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 863638009415 elongation factor Tu; Reviewed; Region: PRK00049 863638009416 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 863638009417 G1 box; other site 863638009418 GEF interaction site [polypeptide binding]; other site 863638009419 GTP/Mg2+ binding site [chemical binding]; other site 863638009420 Switch I region; other site 863638009421 G2 box; other site 863638009422 G3 box; other site 863638009423 Switch II region; other site 863638009424 G4 box; other site 863638009425 G5 box; other site 863638009426 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 863638009427 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 863638009428 Antibiotic Binding Site [chemical binding]; other site 863638009429 RNA polymerase factor sigma-70; Validated; Region: PRK08295 863638009430 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 863638009431 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 863638009432 DNA binding residues [nucleotide binding] 863638009433 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 863638009434 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 863638009435 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 863638009436 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 863638009437 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 863638009438 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 863638009439 active site 863638009440 metal binding site [ion binding]; metal-binding site 863638009441 dimerization interface [polypeptide binding]; other site 863638009442 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 863638009443 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 863638009444 substrate binding site [chemical binding]; other site 863638009445 active site 863638009446 catalytic residues [active] 863638009447 heterodimer interface [polypeptide binding]; other site 863638009448 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 863638009449 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 863638009450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638009451 catalytic residue [active] 863638009452 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 863638009453 active site 863638009454 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 863638009455 active site 863638009456 ribulose/triose binding site [chemical binding]; other site 863638009457 phosphate binding site [ion binding]; other site 863638009458 substrate (anthranilate) binding pocket [chemical binding]; other site 863638009459 product (indole) binding pocket [chemical binding]; other site 863638009460 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 863638009461 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 863638009462 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 863638009463 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 863638009464 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 863638009465 glutamine binding [chemical binding]; other site 863638009466 catalytic triad [active] 863638009467 anthranilate synthase component I; Provisional; Region: PRK13570 863638009468 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 863638009469 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 863638009470 lysine transporter; Provisional; Region: PRK10836 863638009471 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 863638009472 Uncharacterized conserved protein [Function unknown]; Region: COG1433 863638009473 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 863638009474 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 863638009475 PYR/PP interface [polypeptide binding]; other site 863638009476 dimer interface [polypeptide binding]; other site 863638009477 TPP binding site [chemical binding]; other site 863638009478 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 863638009479 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 863638009480 TPP-binding site [chemical binding]; other site 863638009481 dimer interface [polypeptide binding]; other site 863638009482 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 863638009483 tartrate dehydrogenase; Provisional; Region: PRK08194 863638009484 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 863638009485 3-isopropylmalate dehydratase, small subunit; Region: leud; TIGR02084 863638009486 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 863638009487 substrate binding site [chemical binding]; other site 863638009488 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 863638009489 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 863638009490 substrate binding site [chemical binding]; other site 863638009491 ligand binding site [chemical binding]; other site 863638009492 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 863638009493 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 863638009494 active site 863638009495 catalytic residues [active] 863638009496 metal binding site [ion binding]; metal-binding site 863638009497 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 863638009498 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 863638009499 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 863638009500 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 863638009501 putative valine binding site [chemical binding]; other site 863638009502 dimer interface [polypeptide binding]; other site 863638009503 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 863638009504 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 863638009505 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 863638009506 active site 863638009507 HIGH motif; other site 863638009508 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 863638009509 KMSKS motif; other site 863638009510 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 863638009511 tRNA binding surface [nucleotide binding]; other site 863638009512 anticodon binding site; other site 863638009513 prolyl-tRNA synthetase; Provisional; Region: PRK09194 863638009514 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 863638009515 dimer interface [polypeptide binding]; other site 863638009516 motif 1; other site 863638009517 active site 863638009518 motif 2; other site 863638009519 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 863638009520 putative deacylase active site [active] 863638009521 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 863638009522 active site 863638009523 motif 3; other site 863638009524 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 863638009525 anticodon binding site; other site 863638009526 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 863638009527 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 863638009528 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 863638009529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638009530 dimer interface [polypeptide binding]; other site 863638009531 conserved gate region; other site 863638009532 putative PBP binding loops; other site 863638009533 ABC-ATPase subunit interface; other site 863638009534 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 863638009535 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 863638009536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638009537 putative PBP binding loops; other site 863638009538 dimer interface [polypeptide binding]; other site 863638009539 ABC-ATPase subunit interface; other site 863638009540 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 863638009541 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 863638009542 Walker A/P-loop; other site 863638009543 ATP binding site [chemical binding]; other site 863638009544 Q-loop/lid; other site 863638009545 ABC transporter signature motif; other site 863638009546 Walker B; other site 863638009547 D-loop; other site 863638009548 H-loop/switch region; other site 863638009549 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 863638009550 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 863638009551 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 863638009552 Walker A/P-loop; other site 863638009553 ATP binding site [chemical binding]; other site 863638009554 Q-loop/lid; other site 863638009555 ABC transporter signature motif; other site 863638009556 Walker B; other site 863638009557 D-loop; other site 863638009558 H-loop/switch region; other site 863638009559 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 863638009560 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 863638009561 substrate binding site; other site 863638009562 dimer interface; other site 863638009563 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 863638009564 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 863638009565 putative active site [active] 863638009566 TRAM domain; Region: TRAM; cl01282 863638009567 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 863638009568 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 863638009569 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 863638009570 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 863638009571 Helix-hairpin-helix motif; Region: HHH; pfam00633 863638009572 DNA repair protein RadA; Provisional; Region: PRK11823 863638009573 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 863638009574 Walker A motif/ATP binding site; other site 863638009575 ATP binding site [chemical binding]; other site 863638009576 Walker B motif; other site 863638009577 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 863638009578 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 863638009579 Clp amino terminal domain; Region: Clp_N; pfam02861 863638009580 Clp amino terminal domain; Region: Clp_N; pfam02861 863638009581 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638009582 Walker A motif; other site 863638009583 ATP binding site [chemical binding]; other site 863638009584 Walker B motif; other site 863638009585 arginine finger; other site 863638009586 UvrB/uvrC motif; Region: UVR; pfam02151 863638009587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638009588 Walker A motif; other site 863638009589 ATP binding site [chemical binding]; other site 863638009590 Walker B motif; other site 863638009591 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 863638009592 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 863638009593 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 863638009594 ADP binding site [chemical binding]; other site 863638009595 phosphagen binding site; other site 863638009596 substrate specificity loop; other site 863638009597 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 863638009598 UvrB/uvrC motif; Region: UVR; pfam02151 863638009599 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 863638009600 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 863638009601 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 863638009602 glycyl-tRNA synthetase; Provisional; Region: PRK04173 863638009603 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 863638009604 motif 1; other site 863638009605 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 863638009606 active site 863638009607 motif 2; other site 863638009608 motif 3; other site 863638009609 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 863638009610 anticodon binding site; other site 863638009611 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 863638009612 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 863638009613 dimer interface [polypeptide binding]; other site 863638009614 putative anticodon binding site; other site 863638009615 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 863638009616 motif 1; other site 863638009617 active site 863638009618 motif 2; other site 863638009619 motif 3; other site 863638009620 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 863638009621 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 863638009622 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 863638009623 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 863638009624 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 863638009625 FMN binding site [chemical binding]; other site 863638009626 active site 863638009627 catalytic residues [active] 863638009628 substrate binding site [chemical binding]; other site 863638009629 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 863638009630 nucleotide binding site [chemical binding]; other site 863638009631 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 863638009632 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 863638009633 Potassium binding sites [ion binding]; other site 863638009634 Cesium cation binding sites [ion binding]; other site 863638009635 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 863638009636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638009637 Walker A motif; other site 863638009638 ATP binding site [chemical binding]; other site 863638009639 Walker B motif; other site 863638009640 arginine finger; other site 863638009641 Peptidase family M41; Region: Peptidase_M41; pfam01434 863638009642 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 863638009643 active site 863638009644 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 863638009645 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 863638009646 Ligand Binding Site [chemical binding]; other site 863638009647 TilS substrate C-terminal domain; Region: TilS_C; smart00977 863638009648 stage II sporulation protein E; Region: spore_II_E; TIGR02865 863638009649 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 863638009650 hypothetical protein; Provisional; Region: PRK05807 863638009651 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 863638009652 RNA binding site [nucleotide binding]; other site 863638009653 Septum formation initiator; Region: DivIC; pfam04977 863638009654 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 863638009655 sporulation protein YabP; Region: spore_yabP; TIGR02892 863638009656 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 863638009657 RNA binding surface [nucleotide binding]; other site 863638009658 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 863638009659 IHF dimer interface [polypeptide binding]; other site 863638009660 IHF - DNA interface [nucleotide binding]; other site 863638009661 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 863638009662 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 863638009663 putative SAM binding site [chemical binding]; other site 863638009664 putative homodimer interface [polypeptide binding]; other site 863638009665 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 863638009666 homodimer interface [polypeptide binding]; other site 863638009667 metal binding site [ion binding]; metal-binding site 863638009668 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 863638009669 homodimer interface [polypeptide binding]; other site 863638009670 active site 863638009671 putative chemical substrate binding site [chemical binding]; other site 863638009672 metal binding site [ion binding]; metal-binding site 863638009673 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 863638009674 stage V sporulation protein B; Region: spore_V_B; TIGR02900 863638009675 stage V sporulation protein T; Region: spore_V_T; TIGR02851 863638009676 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 863638009677 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 863638009678 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 863638009679 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 863638009680 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 863638009681 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 863638009682 ATP binding site [chemical binding]; other site 863638009683 putative Mg++ binding site [ion binding]; other site 863638009684 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 863638009685 nucleotide binding region [chemical binding]; other site 863638009686 ATP-binding site [chemical binding]; other site 863638009687 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 863638009688 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 863638009689 putative active site [active] 863638009690 catalytic residue [active] 863638009691 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 863638009692 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 863638009693 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 863638009694 protein binding site [polypeptide binding]; other site 863638009695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638009696 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638009697 dimerization interface [polypeptide binding]; other site 863638009698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638009699 dimer interface [polypeptide binding]; other site 863638009700 phosphorylation site [posttranslational modification] 863638009701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638009702 ATP binding site [chemical binding]; other site 863638009703 Mg2+ binding site [ion binding]; other site 863638009704 G-X-G motif; other site 863638009705 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638009706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638009707 active site 863638009708 phosphorylation site [posttranslational modification] 863638009709 intermolecular recognition site; other site 863638009710 dimerization interface [polypeptide binding]; other site 863638009711 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638009712 DNA binding site [nucleotide binding] 863638009713 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 863638009714 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 863638009715 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 863638009716 active site 863638009717 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 863638009718 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 863638009719 Substrate binding site; other site 863638009720 Mg++ binding site; other site 863638009721 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 863638009722 active site 863638009723 substrate binding site [chemical binding]; other site 863638009724 CoA binding site [chemical binding]; other site 863638009725 regulatory protein SpoVG; Reviewed; Region: PRK13259 863638009726 pur operon repressor; Provisional; Region: PRK09213 863638009727 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 863638009728 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 863638009729 active site 863638009730 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 863638009731 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 863638009732 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 863638009733 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 863638009734 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 863638009735 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 863638009736 active site 863638009737 FMN binding site [chemical binding]; other site 863638009738 substrate binding site [chemical binding]; other site 863638009739 homotetramer interface [polypeptide binding]; other site 863638009740 catalytic residue [active] 863638009741 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 863638009742 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 863638009743 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 863638009744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638009745 active site 863638009746 motif I; other site 863638009747 motif II; other site 863638009748 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 863638009749 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 863638009750 Predicted membrane protein [Function unknown]; Region: COG4640 863638009751 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 863638009752 Predicted membrane protein [Function unknown]; Region: COG4640 863638009753 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 863638009754 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 863638009755 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 863638009756 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 863638009757 Walker A/P-loop; other site 863638009758 ATP binding site [chemical binding]; other site 863638009759 Q-loop/lid; other site 863638009760 ABC transporter signature motif; other site 863638009761 Walker B; other site 863638009762 D-loop; other site 863638009763 H-loop/switch region; other site 863638009764 TOBE domain; Region: TOBE_2; pfam08402 863638009765 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 863638009766 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638009767 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 863638009768 putative DNA binding site [nucleotide binding]; other site 863638009769 putative Zn2+ binding site [ion binding]; other site 863638009770 Uncharacterized membrane protein [Function unknown]; Region: COG3949 863638009771 Radical SAM superfamily; Region: Radical_SAM; pfam04055 863638009772 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638009773 FeS/SAM binding site; other site 863638009774 Heme NO binding; Region: HNOB; pfam07700 863638009775 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 863638009776 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 863638009777 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638009778 dimer interface [polypeptide binding]; other site 863638009779 putative CheW interface [polypeptide binding]; other site 863638009780 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 863638009781 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 863638009782 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 863638009783 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 863638009784 active site 863638009785 catalytic triad [active] 863638009786 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 863638009787 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 863638009788 active site 863638009789 catalytic triad [active] 863638009790 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638009791 non-specific DNA binding site [nucleotide binding]; other site 863638009792 salt bridge; other site 863638009793 sequence-specific DNA binding site [nucleotide binding]; other site 863638009794 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 863638009795 Catalytic site [active] 863638009796 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 863638009797 glutamate racemase; Provisional; Region: PRK00865 863638009798 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 863638009799 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 863638009800 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638009801 Zn2+ binding site [ion binding]; other site 863638009802 Mg2+ binding site [ion binding]; other site 863638009803 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 863638009804 pyrroline-5-carboxylate reductase; Region: PLN02688 863638009805 gamma-glutamyl kinase; Provisional; Region: PRK05429 863638009806 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 863638009807 nucleotide binding site [chemical binding]; other site 863638009808 homotetrameric interface [polypeptide binding]; other site 863638009809 putative phosphate binding site [ion binding]; other site 863638009810 putative allosteric binding site; other site 863638009811 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 863638009812 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 863638009813 putative catalytic cysteine [active] 863638009814 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 863638009815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638009816 Coenzyme A binding pocket [chemical binding]; other site 863638009817 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 863638009818 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 863638009819 putative dimer interface [polypeptide binding]; other site 863638009820 putative anticodon binding site; other site 863638009821 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 863638009822 homodimer interface [polypeptide binding]; other site 863638009823 motif 1; other site 863638009824 motif 2; other site 863638009825 active site 863638009826 motif 3; other site 863638009827 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 863638009828 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 863638009829 DNA binding site [nucleotide binding] 863638009830 active site 863638009831 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 863638009832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638009833 Walker A motif; other site 863638009834 ATP binding site [chemical binding]; other site 863638009835 Walker B motif; other site 863638009836 Uncharacterized conserved protein [Function unknown]; Region: COG3874 863638009837 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 863638009838 Putative zinc-finger; Region: zf-HC2; pfam13490 863638009839 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 863638009840 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 863638009841 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 863638009842 DNA binding residues [nucleotide binding] 863638009843 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 863638009844 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 863638009845 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 863638009846 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 863638009847 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 863638009848 Walker A/P-loop; other site 863638009849 ATP binding site [chemical binding]; other site 863638009850 Q-loop/lid; other site 863638009851 ABC transporter signature motif; other site 863638009852 Walker B; other site 863638009853 D-loop; other site 863638009854 H-loop/switch region; other site 863638009855 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 863638009856 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 863638009857 HlyD family secretion protein; Region: HlyD_3; pfam13437 863638009858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638009859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638009860 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638009861 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009862 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009863 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009864 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638009865 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009866 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009867 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009868 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638009869 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 863638009870 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 863638009871 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638009872 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009873 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009874 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009875 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 863638009876 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 863638009877 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638009878 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009879 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009880 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009881 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638009882 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009883 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009884 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009885 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 863638009886 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638009887 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009888 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009889 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009890 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638009891 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009892 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009893 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009894 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638009895 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009896 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638009897 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009898 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638009899 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 863638009900 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 863638009901 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 863638009902 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 863638009903 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 863638009904 dimer interface [polypeptide binding]; other site 863638009905 putative radical transfer pathway; other site 863638009906 diiron center [ion binding]; other site 863638009907 tyrosyl radical; other site 863638009908 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088 863638009909 Class I ribonucleotide reductase; Region: RNR_I; cd01679 863638009910 active site 863638009911 dimer interface [polypeptide binding]; other site 863638009912 catalytic residues [active] 863638009913 effector binding site; other site 863638009914 R2 peptide binding site; other site 863638009915 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638009916 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009917 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009918 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009919 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638009920 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638009921 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009922 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009923 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009924 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638009925 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638009926 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009927 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009928 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009929 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638009930 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 863638009931 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638009932 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009933 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009934 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009935 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638009936 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638009937 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009938 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009939 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638009940 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638009941 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 863638009942 Leucine rich repeat; Region: LRR_8; pfam13855 863638009943 Substrate binding site [chemical binding]; other site 863638009944 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 863638009945 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 863638009946 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 863638009947 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 863638009948 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 863638009949 Walker A/P-loop; other site 863638009950 ATP binding site [chemical binding]; other site 863638009951 Q-loop/lid; other site 863638009952 ABC transporter signature motif; other site 863638009953 Walker B; other site 863638009954 D-loop; other site 863638009955 H-loop/switch region; other site 863638009956 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 863638009957 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 863638009958 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638009959 Walker A/P-loop; other site 863638009960 ATP binding site [chemical binding]; other site 863638009961 Q-loop/lid; other site 863638009962 ABC transporter signature motif; other site 863638009963 Walker B; other site 863638009964 D-loop; other site 863638009965 H-loop/switch region; other site 863638009966 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 863638009967 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 863638009968 dimerization interface [polypeptide binding]; other site 863638009969 putative Zn2+ binding site [ion binding]; other site 863638009970 putative DNA binding site [nucleotide binding]; other site 863638009971 EDD domain protein, DegV family; Region: DegV; TIGR00762 863638009972 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 863638009973 amino acid transporter; Region: 2A0306; TIGR00909 863638009974 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 863638009975 Response regulator receiver domain; Region: Response_reg; pfam00072 863638009976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638009977 intermolecular recognition site; other site 863638009978 active site 863638009979 dimerization interface [polypeptide binding]; other site 863638009980 YcbB domain; Region: YcbB; pfam08664 863638009981 FeS assembly ATPase SufC; Region: sufC; TIGR01978 863638009982 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 863638009983 Walker A/P-loop; other site 863638009984 ATP binding site [chemical binding]; other site 863638009985 Q-loop/lid; other site 863638009986 ABC transporter signature motif; other site 863638009987 Walker B; other site 863638009988 D-loop; other site 863638009989 H-loop/switch region; other site 863638009990 FeS assembly protein SufB; Region: sufB; TIGR01980 863638009991 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 863638009992 FeS assembly protein SufD; Region: sufD; TIGR01981 863638009993 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 863638009994 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 863638009995 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 863638009996 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 863638009997 catalytic residue [active] 863638009998 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 863638009999 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 863638010000 trimerization site [polypeptide binding]; other site 863638010001 active site 863638010002 O-Antigen ligase; Region: Wzy_C; pfam04932 863638010003 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 863638010004 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 863638010005 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 863638010006 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 863638010007 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 863638010008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 863638010009 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 863638010010 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 863638010011 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 863638010012 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 863638010013 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 863638010014 dimer interface [polypeptide binding]; other site 863638010015 active site 863638010016 metal binding site [ion binding]; metal-binding site 863638010017 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 863638010018 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 863638010019 dimer interface [polypeptide binding]; other site 863638010020 active site 863638010021 metal binding site [ion binding]; metal-binding site 863638010022 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 863638010023 Spore germination protein; Region: Spore_permease; pfam03845 863638010024 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 863638010025 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 863638010026 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 863638010027 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 863638010028 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 863638010029 ATP binding site [chemical binding]; other site 863638010030 putative Mg++ binding site [ion binding]; other site 863638010031 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 863638010032 nucleotide binding region [chemical binding]; other site 863638010033 ATP-binding site [chemical binding]; other site 863638010034 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 863638010035 dimer interface [polypeptide binding]; other site 863638010036 catalytic triad [active] 863638010037 peroxidatic and resolving cysteines [active] 863638010038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 863638010039 binding surface 863638010040 TPR motif; other site 863638010041 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 863638010042 putative metal binding site; other site 863638010043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 863638010044 TPR motif; other site 863638010045 binding surface 863638010046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638010047 TPR motif; other site 863638010048 binding surface 863638010049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638010050 binding surface 863638010051 TPR motif; other site 863638010052 hypothetical protein; Provisional; Region: PRK09946 863638010053 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 863638010054 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 863638010055 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 863638010056 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 863638010057 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638010058 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 863638010059 Acid Phosphatase; Region: Acid_PPase; cl17256 863638010060 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 863638010061 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 863638010062 dimer interface [polypeptide binding]; other site 863638010063 FMN binding site [chemical binding]; other site 863638010064 heat shock protein 90; Provisional; Region: PRK05218 863638010065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638010066 ATP binding site [chemical binding]; other site 863638010067 Mg2+ binding site [ion binding]; other site 863638010068 G-X-G motif; other site 863638010069 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 863638010070 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 863638010071 putative active site [active] 863638010072 catalytic site [active] 863638010073 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 863638010074 putative active site [active] 863638010075 catalytic site [active] 863638010076 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 863638010077 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 863638010078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638010079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638010080 dimer interface [polypeptide binding]; other site 863638010081 phosphorylation site [posttranslational modification] 863638010082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638010083 ATP binding site [chemical binding]; other site 863638010084 Mg2+ binding site [ion binding]; other site 863638010085 G-X-G motif; other site 863638010086 Putative amidase domain; Region: Amidase_6; pfam12671 863638010087 hypothetical protein; Provisional; Region: PRK00872 863638010088 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 863638010089 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638010090 non-specific DNA binding site [nucleotide binding]; other site 863638010091 salt bridge; other site 863638010092 sequence-specific DNA binding site [nucleotide binding]; other site 863638010093 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 863638010094 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 863638010095 substrate binding pocket [chemical binding]; other site 863638010096 membrane-bound complex binding site; other site 863638010097 hinge residues; other site 863638010098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638010099 dimer interface [polypeptide binding]; other site 863638010100 conserved gate region; other site 863638010101 putative PBP binding loops; other site 863638010102 ABC-ATPase subunit interface; other site 863638010103 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 863638010104 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 863638010105 Walker A/P-loop; other site 863638010106 ATP binding site [chemical binding]; other site 863638010107 Q-loop/lid; other site 863638010108 ABC transporter signature motif; other site 863638010109 Walker B; other site 863638010110 D-loop; other site 863638010111 H-loop/switch region; other site 863638010112 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 863638010113 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 863638010114 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 863638010115 Cytochrome P450; Region: p450; cl12078 863638010116 Cytochrome P450; Region: p450; cl12078 863638010117 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 863638010118 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 863638010119 active site 863638010120 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 863638010121 dimer interface [polypeptide binding]; other site 863638010122 substrate binding site [chemical binding]; other site 863638010123 catalytic residues [active] 863638010124 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 863638010125 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 863638010126 active site 863638010127 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme [General function prediction only]; Region: COG2108 863638010128 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638010129 FeS/SAM binding site; other site 863638010130 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 863638010131 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 863638010132 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 863638010133 short chain dehydrogenase; Provisional; Region: PRK09291 863638010134 NADP binding site [chemical binding]; other site 863638010135 active site 863638010136 steroid binding site; other site 863638010137 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 863638010138 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 863638010139 ligand binding site [chemical binding]; other site 863638010140 flexible hinge region; other site 863638010141 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 863638010142 Predicted transcriptional regulators [Transcription]; Region: COG1733 863638010143 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 863638010144 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 863638010145 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638010146 Walker A/P-loop; other site 863638010147 ATP binding site [chemical binding]; other site 863638010148 Q-loop/lid; other site 863638010149 ABC transporter signature motif; other site 863638010150 Walker B; other site 863638010151 D-loop; other site 863638010152 H-loop/switch region; other site 863638010153 ABC transporter; Region: ABC_tran_2; pfam12848 863638010154 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 863638010155 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 863638010156 synthetase active site [active] 863638010157 NTP binding site [chemical binding]; other site 863638010158 metal binding site [ion binding]; metal-binding site 863638010159 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 863638010160 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 863638010161 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 863638010162 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 863638010163 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 863638010164 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638010165 FeS/SAM binding site; other site 863638010166 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 863638010167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638010168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638010169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638010170 putative transporter; Provisional; Region: PRK10504 863638010171 putative substrate translocation pore; other site 863638010172 lysine transporter; Provisional; Region: PRK10836 863638010173 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 863638010174 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 863638010175 Transcriptional regulator [Transcription]; Region: LysR; COG0583 863638010176 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 863638010177 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 863638010178 dimerization interface [polypeptide binding]; other site 863638010179 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 863638010180 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 863638010181 conserved cys residue [active] 863638010182 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 863638010183 Cache domain; Region: Cache_1; pfam02743 863638010184 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 863638010185 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 863638010186 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638010187 dimer interface [polypeptide binding]; other site 863638010188 putative CheW interface [polypeptide binding]; other site 863638010189 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 863638010190 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 863638010191 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 863638010192 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 863638010193 active site 863638010194 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 863638010195 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 863638010196 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 863638010197 KR domain; Region: KR; pfam08659 863638010198 putative NADP binding site [chemical binding]; other site 863638010199 active site 863638010200 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 863638010201 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 863638010202 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 863638010203 active site 863638010204 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 863638010205 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 863638010206 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 863638010207 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 863638010208 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 863638010209 FMN binding site [chemical binding]; other site 863638010210 dimer interface [polypeptide binding]; other site 863638010211 Transcriptional regulator [Transcription]; Region: LysR; COG0583 863638010212 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 863638010213 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 863638010214 putative dimerization interface [polypeptide binding]; other site 863638010215 Transcriptional regulator [Transcription]; Region: LysR; COG0583 863638010216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 863638010217 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 863638010218 dimerization interface [polypeptide binding]; other site 863638010219 Predicted membrane protein [Function unknown]; Region: COG3619 863638010220 Barstar_SaI14_like contains sequences that are similar to SaI14, an RNAase inhibitor, which are members of the Barstar family. Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds...; Region: Barstar_SaI14_like; cd05143 863638010221 putative RNAase interaction site [polypeptide binding]; other site 863638010222 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 863638010223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638010224 putative substrate translocation pore; other site 863638010225 Major Facilitator Superfamily; Region: MFS_1; pfam07690 863638010226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638010227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638010228 Predicted transcriptional regulators [Transcription]; Region: COG1695 863638010229 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 863638010230 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 863638010231 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 863638010232 Enoate reductase (ER)-like FMN-binding domain. Enoate reductase catalyzes the NADH-dependent reduction of carbon-carbon double bonds of several molecules, including nonactivated 2-enoates, alpha,beta-unsaturated aldehydes, cyclic ketones, and...; Region: ER_like_FMN; cd02931 863638010233 putative active site [active] 863638010234 putative FMN binding site [chemical binding]; other site 863638010235 putative substrate binding site [chemical binding]; other site 863638010236 putative catalytic residue [active] 863638010237 putative 4Fe-4S cluster binding site [ion binding]; other site 863638010238 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 863638010239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 863638010240 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 863638010241 Predicted membrane protein [Function unknown]; Region: COG2323 863638010242 Pectinesterase; Region: Pectinesterase; pfam01095 863638010243 putative pectinesterase; Region: PLN02432; cl01911 863638010244 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638010245 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 863638010246 Coenzyme A binding pocket [chemical binding]; other site 863638010247 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 863638010248 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 863638010249 NAD binding site [chemical binding]; other site 863638010250 catalytic Zn binding site [ion binding]; other site 863638010251 structural Zn binding site [ion binding]; other site 863638010252 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 863638010253 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 863638010254 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 863638010255 NodB motif; other site 863638010256 active site 863638010257 catalytic site [active] 863638010258 Zn binding site [ion binding]; other site 863638010259 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 863638010260 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 863638010261 active site 863638010262 catalytic tetrad [active] 863638010263 Uncharacterized conserved protein [Function unknown]; Region: COG5663 863638010264 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 863638010265 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 863638010266 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 863638010267 hypothetical protein; Reviewed; Region: PRK09588 863638010268 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 863638010269 hypothetical protein; Reviewed; Region: PRK09588 863638010270 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 863638010271 putative peptide chain release factor H; Region: release_prfH; TIGR03072 863638010272 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 863638010273 WYL domain; Region: WYL; pfam13280 863638010274 WYL domain; Region: WYL; pfam13280 863638010275 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638010276 dimer interface [polypeptide binding]; other site 863638010277 putative CheW interface [polypeptide binding]; other site 863638010278 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 863638010279 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 863638010280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638010281 active site 863638010282 phosphorylation site [posttranslational modification] 863638010283 intermolecular recognition site; other site 863638010284 dimerization interface [polypeptide binding]; other site 863638010285 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 863638010286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638010287 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638010288 dimer interface [polypeptide binding]; other site 863638010289 phosphorylation site [posttranslational modification] 863638010290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638010291 ATP binding site [chemical binding]; other site 863638010292 Mg2+ binding site [ion binding]; other site 863638010293 G-X-G motif; other site 863638010294 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 863638010295 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 863638010296 dimer interface [polypeptide binding]; other site 863638010297 active site 863638010298 metal binding site [ion binding]; metal-binding site 863638010299 Uncharacterized conserved protein [Function unknown]; Region: COG1359 863638010300 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 863638010301 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 863638010302 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 863638010303 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 863638010304 putative NADH binding site [chemical binding]; other site 863638010305 putative active site [active] 863638010306 nudix motif; other site 863638010307 putative metal binding site [ion binding]; other site 863638010308 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 863638010309 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 863638010310 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638010311 dimer interface [polypeptide binding]; other site 863638010312 putative CheW interface [polypeptide binding]; other site 863638010313 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 863638010314 substrate binding site [chemical binding]; other site 863638010315 Predicted transcriptional regulators [Transcription]; Region: COG1733 863638010316 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 863638010317 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 863638010318 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 863638010319 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 863638010320 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 863638010321 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 863638010322 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 863638010323 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 863638010324 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 863638010325 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 863638010326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638010327 Walker A/P-loop; other site 863638010328 ATP binding site [chemical binding]; other site 863638010329 Q-loop/lid; other site 863638010330 ABC transporter signature motif; other site 863638010331 Walker B; other site 863638010332 D-loop; other site 863638010333 H-loop/switch region; other site 863638010334 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 863638010335 MarR family; Region: MarR_2; pfam12802 863638010336 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 863638010337 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 863638010338 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 863638010339 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 863638010340 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 863638010341 active site 863638010342 FMN binding site [chemical binding]; other site 863638010343 substrate binding site [chemical binding]; other site 863638010344 putative catalytic residue [active] 863638010345 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 863638010346 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 863638010347 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 863638010348 Transcriptional regulator [Transcription]; Region: LysR; COG0583 863638010349 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 863638010350 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 863638010351 dimerization interface [polypeptide binding]; other site 863638010352 substrate binding pocket [chemical binding]; other site 863638010353 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 863638010354 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638010355 Zn2+ binding site [ion binding]; other site 863638010356 Mg2+ binding site [ion binding]; other site 863638010357 GH3 auxin-responsive promoter; Region: GH3; pfam03321 863638010358 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 863638010359 Transcriptional regulators [Transcription]; Region: MarR; COG1846 863638010360 MarR family; Region: MarR_2; pfam12802 863638010361 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 863638010362 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 863638010363 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638010364 Walker A/P-loop; other site 863638010365 ATP binding site [chemical binding]; other site 863638010366 Q-loop/lid; other site 863638010367 ABC transporter signature motif; other site 863638010368 Walker B; other site 863638010369 D-loop; other site 863638010370 H-loop/switch region; other site 863638010371 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 863638010372 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 863638010373 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 863638010374 Walker A/P-loop; other site 863638010375 ATP binding site [chemical binding]; other site 863638010376 Q-loop/lid; other site 863638010377 ABC transporter signature motif; other site 863638010378 Walker B; other site 863638010379 D-loop; other site 863638010380 H-loop/switch region; other site 863638010381 Staygreen protein; Region: Staygreen; pfam12638 863638010382 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 863638010383 Transcriptional regulators [Transcription]; Region: MarR; COG1846 863638010384 MarR family; Region: MarR_2; pfam12802 863638010385 Methyltransferase domain; Region: Methyltransf_23; pfam13489 863638010386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638010387 S-adenosylmethionine binding site [chemical binding]; other site 863638010388 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 863638010389 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 863638010390 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 863638010391 catalytic residue [active] 863638010392 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 863638010393 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 863638010394 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 863638010395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638010396 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 863638010397 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 863638010398 Coenzyme A binding pocket [chemical binding]; other site 863638010399 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 863638010400 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 863638010401 putative active site [active] 863638010402 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 863638010403 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 863638010404 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 863638010405 active site turn [active] 863638010406 phosphorylation site [posttranslational modification] 863638010407 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 863638010408 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 863638010409 NAD binding site [chemical binding]; other site 863638010410 sugar binding site [chemical binding]; other site 863638010411 divalent metal binding site [ion binding]; other site 863638010412 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 863638010413 dimer interface [polypeptide binding]; other site 863638010414 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 863638010415 HPr interaction site; other site 863638010416 glycerol kinase (GK) interaction site [polypeptide binding]; other site 863638010417 active site 863638010418 phosphorylation site [posttranslational modification] 863638010419 hybrid cluster protein; Provisional; Region: PRK05290 863638010420 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 863638010421 ACS interaction site; other site 863638010422 CODH interaction site; other site 863638010423 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 863638010424 hybrid metal cluster; other site 863638010425 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 863638010426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638010427 active site 863638010428 phosphorylation site [posttranslational modification] 863638010429 intermolecular recognition site; other site 863638010430 dimerization interface [polypeptide binding]; other site 863638010431 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 863638010432 DNA binding residues [nucleotide binding] 863638010433 dimerization interface [polypeptide binding]; other site 863638010434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 863638010435 Histidine kinase; Region: HisKA_3; pfam07730 863638010436 MMPL family; Region: MMPL; pfam03176 863638010437 Protein export membrane protein; Region: SecD_SecF; cl14618 863638010438 MMPL family; Region: MMPL; pfam03176 863638010439 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 863638010440 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638010441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638010442 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 863638010443 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 863638010444 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 863638010445 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 863638010446 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 863638010447 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 863638010448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 863638010449 putative DNA binding site [nucleotide binding]; other site 863638010450 putative Zn2+ binding site [ion binding]; other site 863638010451 Predicted membrane protein [Function unknown]; Region: COG4129 863638010452 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 863638010453 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 863638010454 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 863638010455 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 863638010456 ATP binding site [chemical binding]; other site 863638010457 putative Mg++ binding site [ion binding]; other site 863638010458 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 863638010459 nucleotide binding region [chemical binding]; other site 863638010460 ATP-binding site [chemical binding]; other site 863638010461 DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176 863638010462 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 863638010463 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 863638010464 generic binding surface II; other site 863638010465 generic binding surface I; other site 863638010466 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 863638010467 active site 863638010468 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 863638010469 active site 863638010470 catalytic site [active] 863638010471 substrate binding site [chemical binding]; other site 863638010472 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 863638010473 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 863638010474 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 863638010475 DNA binding residues [nucleotide binding] 863638010476 dimer interface [polypeptide binding]; other site 863638010477 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 863638010478 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 863638010479 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 863638010480 hypothetical protein; Provisional; Region: PRK10281 863638010481 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 863638010482 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 863638010483 catalytic residues [active] 863638010484 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 863638010485 active site 863638010486 catalytic triad [active] 863638010487 oxyanion hole [active] 863638010488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638010489 binding surface 863638010490 TPR motif; other site 863638010491 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638010492 binding surface 863638010493 TPR repeat; Region: TPR_11; pfam13414 863638010494 TPR motif; other site 863638010495 TPR repeat; Region: TPR_11; pfam13414 863638010496 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638010497 binding surface 863638010498 TPR repeat; Region: TPR_11; pfam13414 863638010499 TPR motif; other site 863638010500 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 863638010501 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 863638010502 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 863638010503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638010504 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 863638010505 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 863638010506 inhibitor binding site; inhibition site 863638010507 active site 863638010508 amino acid permease (yeast); Region: 2A0310; TIGR00913 863638010509 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 863638010510 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 863638010511 FMN binding site [chemical binding]; other site 863638010512 active site 863638010513 catalytic residues [active] 863638010514 substrate binding site [chemical binding]; other site 863638010515 Uncharacterized conserved protein [Function unknown]; Region: COG3543 863638010516 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 863638010517 BNR repeat-like domain; Region: BNR_2; pfam13088 863638010518 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 863638010519 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 863638010520 DNA binding residues [nucleotide binding] 863638010521 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 863638010522 nucleotide binding site [chemical binding]; other site 863638010523 V-type ATP synthase subunit I; Validated; Region: PRK05771 863638010524 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 863638010525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 863638010526 NAD(P) binding site [chemical binding]; other site 863638010527 active site 863638010528 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 863638010529 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 863638010530 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 863638010531 Isochorismatase family; Region: Isochorismatase; pfam00857 863638010532 catalytic triad [active] 863638010533 conserved cis-peptide bond; other site 863638010534 Transcriptional regulator [Transcription]; Region: LysR; COG0583 863638010535 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 863638010536 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 863638010537 dimerization interface [polypeptide binding]; other site 863638010538 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 863638010539 dimer interface [polypeptide binding]; other site 863638010540 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 863638010541 dimer interface [polypeptide binding]; other site 863638010542 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 863638010543 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 863638010544 GIY-YIG motif/motif A; other site 863638010545 active site 863638010546 catalytic site [active] 863638010547 putative DNA binding site [nucleotide binding]; other site 863638010548 metal binding site [ion binding]; metal-binding site 863638010549 UvrB/uvrC motif; Region: UVR; pfam02151 863638010550 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 863638010551 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 863638010552 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 863638010553 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 863638010554 active site 863638010555 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 863638010556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638010557 non-specific DNA binding site [nucleotide binding]; other site 863638010558 salt bridge; other site 863638010559 sequence-specific DNA binding site [nucleotide binding]; other site 863638010560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638010561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638010562 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 863638010563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638010564 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 863638010565 putative substrate translocation pore; other site 863638010566 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 863638010567 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 863638010568 DNA binding residues [nucleotide binding] 863638010569 dimer interface [polypeptide binding]; other site 863638010570 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 863638010571 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 863638010572 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638010573 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 863638010574 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638010575 dimer interface [polypeptide binding]; other site 863638010576 putative CheW interface [polypeptide binding]; other site 863638010577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638010578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 863638010579 dimerization interface [polypeptide binding]; other site 863638010580 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638010581 DNA binding site [nucleotide binding] 863638010582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638010583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638010584 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 863638010585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638010586 putative substrate translocation pore; other site 863638010587 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 863638010588 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 863638010589 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 863638010590 putative FMN binding site [chemical binding]; other site 863638010591 short chain dehydrogenase; Provisional; Region: PRK06197 863638010592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 863638010593 NAD(P) binding site [chemical binding]; other site 863638010594 active site 863638010595 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 863638010596 MarR family; Region: MarR; pfam01047 863638010597 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 863638010598 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 863638010599 Predicted transcriptional regulators [Transcription]; Region: COG1733 863638010600 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 863638010601 Predicted transcriptional regulators [Transcription]; Region: COG1733 863638010602 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 863638010603 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 863638010604 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 863638010605 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 863638010606 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 863638010607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638010608 FeS/SAM binding site; other site 863638010609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 863638010610 Predicted transcriptional regulator [Transcription]; Region: COG2378 863638010611 HTH domain; Region: HTH_11; pfam08279 863638010612 WYL domain; Region: WYL; pfam13280 863638010613 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 863638010614 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 863638010615 Predicted transcriptional regulators [Transcription]; Region: COG1733 863638010616 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 863638010617 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 863638010618 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 863638010619 substrate binding site [chemical binding]; other site 863638010620 ATP binding site [chemical binding]; other site 863638010621 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 863638010622 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 863638010623 AP (apurinic/apyrimidinic) site pocket; other site 863638010624 Metal-binding active site; metal-binding site 863638010625 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 863638010626 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 863638010627 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 863638010628 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 863638010629 putative active site [active] 863638010630 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 863638010631 dimer interface [polypeptide binding]; other site 863638010632 active site 863638010633 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 863638010634 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 863638010635 DNA-binding site [nucleotide binding]; DNA binding site 863638010636 UTRA domain; Region: UTRA; pfam07702 863638010637 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 863638010638 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 863638010639 NADP binding site [chemical binding]; other site 863638010640 putative substrate binding site [chemical binding]; other site 863638010641 active site 863638010642 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638010643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638010644 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 863638010645 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 863638010646 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 863638010647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638010648 putative substrate translocation pore; other site 863638010649 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 863638010650 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 863638010651 DNA binding residues [nucleotide binding] 863638010652 putative dimer interface [polypeptide binding]; other site 863638010653 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 863638010654 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 863638010655 metal binding site [ion binding]; metal-binding site 863638010656 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 863638010657 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 863638010658 DNA binding residues [nucleotide binding] 863638010659 putative dimer interface [polypeptide binding]; other site 863638010660 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 863638010661 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761 863638010662 DNA binding residues [nucleotide binding] 863638010663 Cache domain; Region: Cache_1; pfam02743 863638010664 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638010665 dimerization interface [polypeptide binding]; other site 863638010666 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638010667 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 863638010668 dimer interface [polypeptide binding]; other site 863638010669 putative CheW interface [polypeptide binding]; other site 863638010670 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 863638010671 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 863638010672 HAMP domain; Region: HAMP; pfam00672 863638010673 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638010674 dimer interface [polypeptide binding]; other site 863638010675 putative CheW interface [polypeptide binding]; other site 863638010676 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 863638010677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 863638010678 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 863638010679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 863638010680 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 863638010681 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 863638010682 putative active site [active] 863638010683 putative NTP binding site [chemical binding]; other site 863638010684 putative nucleic acid binding site [nucleotide binding]; other site 863638010685 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 863638010686 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 863638010687 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 863638010688 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638010689 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 863638010690 dimerization interface [polypeptide binding]; other site 863638010691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638010692 dimer interface [polypeptide binding]; other site 863638010693 phosphorylation site [posttranslational modification] 863638010694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638010695 ATP binding site [chemical binding]; other site 863638010696 Mg2+ binding site [ion binding]; other site 863638010697 G-X-G motif; other site 863638010698 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638010699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638010700 active site 863638010701 phosphorylation site [posttranslational modification] 863638010702 intermolecular recognition site; other site 863638010703 dimerization interface [polypeptide binding]; other site 863638010704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638010705 DNA binding site [nucleotide binding] 863638010706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638010707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638010708 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 863638010709 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 863638010710 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 863638010711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638010712 Walker A/P-loop; other site 863638010713 ATP binding site [chemical binding]; other site 863638010714 Q-loop/lid; other site 863638010715 ABC transporter signature motif; other site 863638010716 Walker B; other site 863638010717 D-loop; other site 863638010718 H-loop/switch region; other site 863638010719 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 863638010720 Predicted transcriptional regulator [Transcription]; Region: COG1959 863638010721 Transcriptional regulator; Region: Rrf2; pfam02082 863638010722 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 863638010723 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 863638010724 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 863638010725 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 863638010726 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 863638010727 Transposase IS200 like; Region: Y1_Tnp; pfam01797 863638010728 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 863638010729 Methyltransferase domain; Region: Methyltransf_26; pfam13659 863638010730 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 863638010731 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 863638010732 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 863638010733 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 863638010734 hypothetical protein; Provisional; Region: PRK05590 863638010735 SEC-C motif; Region: SEC-C; pfam02810 863638010736 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 863638010737 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 863638010738 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 863638010739 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 863638010740 hinge; other site 863638010741 active site 863638010742 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 863638010743 dUTPase; Region: dUTPase_2; pfam08761 863638010744 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 863638010745 active site 863638010746 homodimer interface [polypeptide binding]; other site 863638010747 metal binding site [ion binding]; metal-binding site 863638010748 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 863638010749 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 863638010750 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 863638010751 metal binding site [ion binding]; metal-binding site 863638010752 active site 863638010753 I-site; other site 863638010754 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638010755 dimer interface [polypeptide binding]; other site 863638010756 putative CheW interface [polypeptide binding]; other site 863638010757 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 863638010758 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 863638010759 catalytic residues [active] 863638010760 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 863638010761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 863638010762 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 863638010763 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 863638010764 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 863638010765 active site 863638010766 catalytic residues [active] 863638010767 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 863638010768 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 863638010769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638010770 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638010771 Walker A/P-loop; other site 863638010772 ATP binding site [chemical binding]; other site 863638010773 Q-loop/lid; other site 863638010774 ABC transporter signature motif; other site 863638010775 Walker B; other site 863638010776 D-loop; other site 863638010777 H-loop/switch region; other site 863638010778 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 863638010779 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 863638010780 NAD binding site [chemical binding]; other site 863638010781 dimer interface [polypeptide binding]; other site 863638010782 tetramer (dimer of dimers) interface [polypeptide binding]; other site 863638010783 substrate binding site [chemical binding]; other site 863638010784 Transcriptional regulators [Transcription]; Region: PurR; COG1609 863638010785 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 863638010786 DNA binding site [nucleotide binding] 863638010787 domain linker motif; other site 863638010788 Ligand-binding domain of DNA transcription repressor for the hexuronate utilization operon from Bacillus species and its close homologs from other bacteria, all of which are a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_hexuronate_repressor_like; cd06272 863638010789 putative dimerization interface [polypeptide binding]; other site 863638010790 putative ligand binding site [chemical binding]; other site 863638010791 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 863638010792 NAD(P)H:flavin oxidoreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_2; cd02151 863638010793 putative FMN binding site [chemical binding]; other site 863638010794 Right handed beta helix region; Region: Beta_helix; pfam13229 863638010795 Right handed beta helix region; Region: Beta_helix; pfam13229 863638010796 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 863638010797 HlyD family secretion protein; Region: HlyD_3; pfam13437 863638010798 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638010799 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 863638010800 Walker A/P-loop; other site 863638010801 ATP binding site [chemical binding]; other site 863638010802 Q-loop/lid; other site 863638010803 ABC transporter signature motif; other site 863638010804 Walker B; other site 863638010805 D-loop; other site 863638010806 H-loop/switch region; other site 863638010807 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 863638010808 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 863638010809 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 863638010810 FtsX-like permease family; Region: FtsX; pfam02687 863638010811 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 863638010812 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638010813 Zn2+ binding site [ion binding]; other site 863638010814 Mg2+ binding site [ion binding]; other site 863638010815 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 863638010816 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638010817 Walker A/P-loop; other site 863638010818 ATP binding site [chemical binding]; other site 863638010819 Q-loop/lid; other site 863638010820 ABC transporter signature motif; other site 863638010821 Walker B; other site 863638010822 D-loop; other site 863638010823 H-loop/switch region; other site 863638010824 potential frameshift: common BLAST hit: gi|337738771|ref|YP_004638218.1| aspartyl-tRNA synthetase 863638010825 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 863638010826 motif 3; other site 863638010827 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cd04100 863638010828 Dimer interface [polypeptide binding]; other site 863638010829 anticodon binding site; other site 863638010830 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 863638010831 motif 1; other site 863638010832 dimer interface [polypeptide binding]; other site 863638010833 active site 863638010834 motif 2; other site 863638010835 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638010836 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638010837 DNA topoisomerase III; Provisional; Region: PRK07726 863638010838 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 863638010839 active site 863638010840 putative interdomain interaction site [polypeptide binding]; other site 863638010841 putative metal-binding site [ion binding]; other site 863638010842 putative nucleotide binding site [chemical binding]; other site 863638010843 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 863638010844 domain I; other site 863638010845 DNA binding groove [nucleotide binding] 863638010846 phosphate binding site [ion binding]; other site 863638010847 domain II; other site 863638010848 domain III; other site 863638010849 nucleotide binding site [chemical binding]; other site 863638010850 catalytic site [active] 863638010851 domain IV; other site 863638010852 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 863638010853 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 863638010854 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 863638010855 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 863638010856 biotin carboxylase; Validated; Region: PRK05586 863638010857 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 863638010858 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 863638010859 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 863638010860 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 863638010861 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 863638010862 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 863638010863 carboxyltransferase (CT) interaction site; other site 863638010864 biotinylation site [posttranslational modification]; other site 863638010865 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 863638010866 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 863638010867 dimer interface [polypeptide binding]; other site 863638010868 active site 863638010869 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 863638010870 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 863638010871 NAD(P) binding site [chemical binding]; other site 863638010872 homotetramer interface [polypeptide binding]; other site 863638010873 homodimer interface [polypeptide binding]; other site 863638010874 active site 863638010875 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 863638010876 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 863638010877 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 863638010878 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 863638010879 FMN binding site [chemical binding]; other site 863638010880 substrate binding site [chemical binding]; other site 863638010881 putative catalytic residue [active] 863638010882 acyl carrier protein; Provisional; Region: acpP; PRK00982 863638010883 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 863638010884 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 863638010885 dimer interface [polypeptide binding]; other site 863638010886 active site 863638010887 CoA binding pocket [chemical binding]; other site 863638010888 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 863638010889 MarR family; Region: MarR_2; pfam12802 863638010890 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 863638010891 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 863638010892 FMN binding site [chemical binding]; other site 863638010893 substrate binding site [chemical binding]; other site 863638010894 putative catalytic residue [active] 863638010895 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 863638010896 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638010897 motif II; other site 863638010898 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 863638010899 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 863638010900 FtsX-like permease family; Region: FtsX; pfam02687 863638010901 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 863638010902 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 863638010903 FtsX-like permease family; Region: FtsX; pfam02687 863638010904 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638010905 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 863638010906 Walker A/P-loop; other site 863638010907 ATP binding site [chemical binding]; other site 863638010908 Q-loop/lid; other site 863638010909 ABC transporter signature motif; other site 863638010910 Walker B; other site 863638010911 D-loop; other site 863638010912 H-loop/switch region; other site 863638010913 competence damage-inducible protein A; Provisional; Region: PRK00549 863638010914 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 863638010915 putative MPT binding site; other site 863638010916 Competence-damaged protein; Region: CinA; pfam02464 863638010917 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 863638010918 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 863638010919 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 863638010920 DNA replication protein DnaC; Validated; Region: PRK06835 863638010921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638010922 Walker A motif; other site 863638010923 ATP binding site [chemical binding]; other site 863638010924 Predicted membrane protein [Function unknown]; Region: COG1511 863638010925 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 863638010926 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 863638010927 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 863638010928 HI0933-like protein; Region: HI0933_like; pfam03486 863638010929 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 863638010930 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 863638010931 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 863638010932 active site 863638010933 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 863638010934 active site 863638010935 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 863638010936 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 863638010937 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 863638010938 GDP-binding site [chemical binding]; other site 863638010939 ACT binding site; other site 863638010940 IMP binding site; other site 863638010941 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 863638010942 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 863638010943 putative ADP-binding pocket [chemical binding]; other site 863638010944 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 863638010945 hydroxyglutarate oxidase; Provisional; Region: PRK11728 863638010946 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 863638010947 Rubredoxin [Energy production and conversion]; Region: COG1773 863638010948 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 863638010949 iron binding site [ion binding]; other site 863638010950 Rubrerythrin [Energy production and conversion]; Region: COG1592 863638010951 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 863638010952 diiron binding motif [ion binding]; other site 863638010953 Rubredoxin [Energy production and conversion]; Region: COG1773 863638010954 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 863638010955 iron binding site [ion binding]; other site 863638010956 Rubrerythrin [Energy production and conversion]; Region: COG1592 863638010957 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 863638010958 diiron binding motif [ion binding]; other site 863638010959 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 863638010960 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 863638010961 dimer interface [polypeptide binding]; other site 863638010962 active site 863638010963 catalytic residue [active] 863638010964 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 863638010965 dimer interface [polypeptide binding]; other site 863638010966 active site 863638010967 ADP-ribose binding site [chemical binding]; other site 863638010968 nudix motif; other site 863638010969 metal binding site [ion binding]; metal-binding site 863638010970 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638010971 Zn2+ binding site [ion binding]; other site 863638010972 Mg2+ binding site [ion binding]; other site 863638010973 Transcriptional regulators [Transcription]; Region: FadR; COG2186 863638010974 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 863638010975 DNA-binding site [nucleotide binding]; DNA binding site 863638010976 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 863638010977 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 863638010978 fructuronate transporter; Provisional; Region: PRK10034; cl15264 863638010979 gluconate transporter; Region: gntP; TIGR00791 863638010980 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638010981 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638010982 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 863638010983 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 863638010984 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 863638010985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638010986 Walker A/P-loop; other site 863638010987 ATP binding site [chemical binding]; other site 863638010988 Q-loop/lid; other site 863638010989 ABC transporter signature motif; other site 863638010990 Walker B; other site 863638010991 D-loop; other site 863638010992 H-loop/switch region; other site 863638010993 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 863638010994 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 863638010995 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 863638010996 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 863638010997 AAA ATPase domain; Region: AAA_16; pfam13191 863638010998 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 863638010999 dimerization interface [polypeptide binding]; other site 863638011000 DNA binding residues [nucleotide binding] 863638011001 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 863638011002 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 863638011003 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 863638011004 FtsX-like permease family; Region: FtsX; pfam02687 863638011005 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 863638011006 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 863638011007 Walker A/P-loop; other site 863638011008 ATP binding site [chemical binding]; other site 863638011009 Q-loop/lid; other site 863638011010 ABC transporter signature motif; other site 863638011011 Walker B; other site 863638011012 D-loop; other site 863638011013 H-loop/switch region; other site 863638011014 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 863638011015 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 863638011016 Walker A/P-loop; other site 863638011017 ATP binding site [chemical binding]; other site 863638011018 Q-loop/lid; other site 863638011019 ABC transporter signature motif; other site 863638011020 Walker B; other site 863638011021 D-loop; other site 863638011022 H-loop/switch region; other site 863638011023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638011024 dimer interface [polypeptide binding]; other site 863638011025 conserved gate region; other site 863638011026 putative PBP binding loops; other site 863638011027 ABC-ATPase subunit interface; other site 863638011028 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 863638011029 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 863638011030 substrate binding pocket [chemical binding]; other site 863638011031 membrane-bound complex binding site; other site 863638011032 hinge residues; other site 863638011033 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 863638011034 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 863638011035 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 863638011036 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 863638011037 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 863638011038 active site 863638011039 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 863638011040 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638011041 FeS/SAM binding site; other site 863638011042 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 863638011043 GTP cyclohydrolase I; Provisional; Region: PLN03044 863638011044 active site 863638011045 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 863638011046 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 863638011047 Ligand Binding Site [chemical binding]; other site 863638011048 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 863638011049 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 863638011050 Walker A/P-loop; other site 863638011051 ATP binding site [chemical binding]; other site 863638011052 Q-loop/lid; other site 863638011053 ABC transporter signature motif; other site 863638011054 Walker B; other site 863638011055 D-loop; other site 863638011056 H-loop/switch region; other site 863638011057 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 863638011058 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 863638011059 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 863638011060 Walker A/P-loop; other site 863638011061 ATP binding site [chemical binding]; other site 863638011062 Q-loop/lid; other site 863638011063 ABC transporter signature motif; other site 863638011064 Walker B; other site 863638011065 D-loop; other site 863638011066 H-loop/switch region; other site 863638011067 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 863638011068 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 863638011069 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 863638011070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638011071 dimer interface [polypeptide binding]; other site 863638011072 conserved gate region; other site 863638011073 putative PBP binding loops; other site 863638011074 ABC-ATPase subunit interface; other site 863638011075 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 863638011076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638011077 dimer interface [polypeptide binding]; other site 863638011078 conserved gate region; other site 863638011079 putative PBP binding loops; other site 863638011080 ABC-ATPase subunit interface; other site 863638011081 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 863638011082 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 863638011083 peptide binding site [polypeptide binding]; other site 863638011084 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 863638011085 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 863638011086 peptide binding site [polypeptide binding]; other site 863638011087 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 863638011088 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 863638011089 Walker A/P-loop; other site 863638011090 ATP binding site [chemical binding]; other site 863638011091 Q-loop/lid; other site 863638011092 ABC transporter signature motif; other site 863638011093 Walker B; other site 863638011094 D-loop; other site 863638011095 H-loop/switch region; other site 863638011096 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 863638011097 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 863638011098 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 863638011099 Walker A/P-loop; other site 863638011100 ATP binding site [chemical binding]; other site 863638011101 Q-loop/lid; other site 863638011102 ABC transporter signature motif; other site 863638011103 Walker B; other site 863638011104 D-loop; other site 863638011105 H-loop/switch region; other site 863638011106 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 863638011107 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 863638011108 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 863638011109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638011110 dimer interface [polypeptide binding]; other site 863638011111 conserved gate region; other site 863638011112 putative PBP binding loops; other site 863638011113 ABC-ATPase subunit interface; other site 863638011114 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 863638011115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638011116 dimer interface [polypeptide binding]; other site 863638011117 conserved gate region; other site 863638011118 putative PBP binding loops; other site 863638011119 ABC-ATPase subunit interface; other site 863638011120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 863638011121 non-specific DNA binding site [nucleotide binding]; other site 863638011122 salt bridge; other site 863638011123 sequence-specific DNA binding site [nucleotide binding]; other site 863638011124 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 863638011125 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 863638011126 peptide binding site [polypeptide binding]; other site 863638011127 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 863638011128 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 863638011129 Walker A/P-loop; other site 863638011130 ATP binding site [chemical binding]; other site 863638011131 Q-loop/lid; other site 863638011132 ABC transporter signature motif; other site 863638011133 Walker B; other site 863638011134 D-loop; other site 863638011135 H-loop/switch region; other site 863638011136 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 863638011137 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 863638011138 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 863638011139 Walker A/P-loop; other site 863638011140 ATP binding site [chemical binding]; other site 863638011141 Q-loop/lid; other site 863638011142 ABC transporter signature motif; other site 863638011143 Walker B; other site 863638011144 D-loop; other site 863638011145 H-loop/switch region; other site 863638011146 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 863638011147 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 863638011148 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 863638011149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638011150 dimer interface [polypeptide binding]; other site 863638011151 conserved gate region; other site 863638011152 putative PBP binding loops; other site 863638011153 ABC-ATPase subunit interface; other site 863638011154 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 863638011155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638011156 dimer interface [polypeptide binding]; other site 863638011157 conserved gate region; other site 863638011158 putative PBP binding loops; other site 863638011159 ABC-ATPase subunit interface; other site 863638011160 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 863638011161 non-specific DNA binding site [nucleotide binding]; other site 863638011162 salt bridge; other site 863638011163 sequence-specific DNA binding site [nucleotide binding]; other site 863638011164 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 863638011165 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638011166 non-specific DNA binding site [nucleotide binding]; other site 863638011167 salt bridge; other site 863638011168 sequence-specific DNA binding site [nucleotide binding]; other site 863638011169 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 863638011170 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 863638011171 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638011172 Coenzyme A binding pocket [chemical binding]; other site 863638011173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638011174 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 863638011175 Coenzyme A binding pocket [chemical binding]; other site 863638011176 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 863638011177 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 863638011178 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 863638011179 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 863638011180 Zn2+ binding site [ion binding]; other site 863638011181 Mg2+ binding site [ion binding]; other site 863638011182 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 863638011183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 863638011184 DNA-binding site [nucleotide binding]; DNA binding site 863638011185 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 863638011186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 863638011187 homodimer interface [polypeptide binding]; other site 863638011188 catalytic residue [active] 863638011189 acetolactate synthase; Reviewed; Region: PRK08322 863638011190 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 863638011191 PYR/PP interface [polypeptide binding]; other site 863638011192 dimer interface [polypeptide binding]; other site 863638011193 TPP binding site [chemical binding]; other site 863638011194 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 863638011195 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 863638011196 TPP-binding site [chemical binding]; other site 863638011197 dimer interface [polypeptide binding]; other site 863638011198 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 863638011199 metal-binding site [ion binding] 863638011200 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 863638011201 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 863638011202 metal-binding site [ion binding] 863638011203 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 863638011204 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 863638011205 metal-binding site [ion binding] 863638011206 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 863638011207 Soluble P-type ATPase [General function prediction only]; Region: COG4087 863638011208 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 863638011209 putative homodimer interface [polypeptide binding]; other site 863638011210 putative homotetramer interface [polypeptide binding]; other site 863638011211 putative allosteric switch controlling residues; other site 863638011212 putative metal binding site [ion binding]; other site 863638011213 putative homodimer-homodimer interface [polypeptide binding]; other site 863638011214 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 863638011215 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 863638011216 tetrameric interface [polypeptide binding]; other site 863638011217 activator binding site; other site 863638011218 NADP binding site [chemical binding]; other site 863638011219 substrate binding site [chemical binding]; other site 863638011220 catalytic residues [active] 863638011221 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 863638011222 MgtC family; Region: MgtC; pfam02308 863638011223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638011224 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 863638011225 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 863638011226 Ligand binding site; other site 863638011227 Putative Catalytic site; other site 863638011228 DXD motif; other site 863638011229 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 863638011230 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 863638011231 dimerization interface [polypeptide binding]; other site 863638011232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638011233 dimer interface [polypeptide binding]; other site 863638011234 phosphorylation site [posttranslational modification] 863638011235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638011236 ATP binding site [chemical binding]; other site 863638011237 Mg2+ binding site [ion binding]; other site 863638011238 G-X-G motif; other site 863638011239 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 863638011240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638011241 active site 863638011242 phosphorylation site [posttranslational modification] 863638011243 intermolecular recognition site; other site 863638011244 dimerization interface [polypeptide binding]; other site 863638011245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638011246 DNA binding site [nucleotide binding] 863638011247 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 863638011248 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 863638011249 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 863638011250 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 863638011251 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 863638011252 MarR family; Region: MarR; pfam01047 863638011253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638011254 Major Facilitator Superfamily; Region: MFS_1; pfam07690 863638011255 putative substrate translocation pore; other site 863638011256 Transcriptional regulators [Transcription]; Region: MarR; COG1846 863638011257 MarR family; Region: MarR_2; pfam12802 863638011258 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 863638011259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638011260 dimer interface [polypeptide binding]; other site 863638011261 conserved gate region; other site 863638011262 putative PBP binding loops; other site 863638011263 ABC-ATPase subunit interface; other site 863638011264 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 863638011265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 863638011266 dimer interface [polypeptide binding]; other site 863638011267 conserved gate region; other site 863638011268 putative PBP binding loops; other site 863638011269 ABC-ATPase subunit interface; other site 863638011270 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 863638011271 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 863638011272 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 863638011273 putative DNA binding site [nucleotide binding]; other site 863638011274 putative Zn2+ binding site [ion binding]; other site 863638011275 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 863638011276 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 863638011277 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 863638011278 FOG: CBS domain [General function prediction only]; Region: COG0517 863638011279 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 863638011280 DNA polymerase III subunit beta; Validated; Region: PRK06673 863638011281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 863638011282 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 863638011283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 863638011284 active site 863638011285 phosphorylation site [posttranslational modification] 863638011286 intermolecular recognition site; other site 863638011287 dimerization interface [polypeptide binding]; other site 863638011288 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 863638011289 DNA binding site [nucleotide binding] 863638011290 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 863638011291 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 863638011292 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 863638011293 Ligand Binding Site [chemical binding]; other site 863638011294 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 863638011295 GAF domain; Region: GAF_3; pfam13492 863638011296 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 863638011297 phosphorylation site [posttranslational modification] 863638011298 dimer interface [polypeptide binding]; other site 863638011299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 863638011300 ATP binding site [chemical binding]; other site 863638011301 Mg2+ binding site [ion binding]; other site 863638011302 G-X-G motif; other site 863638011303 potassium-transporting ATPase subunit C; Provisional; Region: PRK13995 863638011304 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 863638011305 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 863638011306 Soluble P-type ATPase [General function prediction only]; Region: COG4087 863638011307 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 863638011308 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 863638011309 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 863638011310 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 863638011311 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 863638011312 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 863638011313 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 863638011314 Cytokine receptor motif; other site 863638011315 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 863638011316 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 863638011317 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638011318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638011319 HAMP domain; Region: HAMP; pfam00672 863638011320 dimerization interface [polypeptide binding]; other site 863638011321 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 863638011322 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638011323 dimer interface [polypeptide binding]; other site 863638011324 putative CheW interface [polypeptide binding]; other site 863638011325 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 863638011326 dimer interface [polypeptide binding]; other site 863638011327 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 863638011328 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 863638011329 putative hydrophobic ligand binding site [chemical binding]; other site 863638011330 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 863638011331 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 863638011332 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638011333 non-specific DNA binding site [nucleotide binding]; other site 863638011334 salt bridge; other site 863638011335 sequence-specific DNA binding site [nucleotide binding]; other site 863638011336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638011337 binding surface 863638011338 Tetratricopeptide repeat; Region: TPR_12; pfam13424 863638011339 TPR motif; other site 863638011340 Tetratricopeptide repeat; Region: TPR_12; pfam13424 863638011341 Predicted membrane protein [Function unknown]; Region: COG1511 863638011342 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 863638011343 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 863638011344 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 863638011345 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 863638011346 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 863638011347 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 863638011348 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 863638011349 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 863638011350 LXG domain of WXG superfamily; Region: LXG; pfam04740 863638011351 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 863638011352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 863638011353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 863638011354 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 863638011355 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 863638011356 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 863638011357 Predicted membrane protein [Function unknown]; Region: COG4499 863638011358 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 863638011359 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 863638011360 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 863638011361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 863638011362 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 863638011363 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 863638011364 putative dimer interface [polypeptide binding]; other site 863638011365 replicative DNA helicase; Provisional; Region: PRK05595 863638011366 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 863638011367 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 863638011368 Walker A motif; other site 863638011369 ATP binding site [chemical binding]; other site 863638011370 Walker B motif; other site 863638011371 DNA binding loops [nucleotide binding] 863638011372 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 863638011373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 863638011374 Walker A motif; other site 863638011375 ATP binding site [chemical binding]; other site 863638011376 Walker B motif; other site 863638011377 arginine finger; other site 863638011378 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 863638011379 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 863638011380 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 863638011381 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 863638011382 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 863638011383 PAS domain; Region: PAS; smart00091 863638011384 putative active site [active] 863638011385 heme pocket [chemical binding]; other site 863638011386 DHH family; Region: DHH; pfam01368 863638011387 DHHA1 domain; Region: DHHA1; pfam02272 863638011388 Predicted membrane protein [Function unknown]; Region: COG4241 863638011389 MazG-like family; Region: MazG-like; pfam12643 863638011390 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 863638011391 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 863638011392 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 863638011393 dimer interface [polypeptide binding]; other site 863638011394 ssDNA binding site [nucleotide binding]; other site 863638011395 tetramer (dimer of dimers) interface [polypeptide binding]; other site 863638011396 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 863638011397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 863638011398 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 863638011399 Mechanosensitive ion channel; Region: MS_channel; pfam00924 863638011400 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 863638011401 ParB-like nuclease domain; Region: ParB; smart00470 863638011402 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 863638011403 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 863638011404 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 863638011405 P-loop; other site 863638011406 Magnesium ion binding site [ion binding]; other site 863638011407 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 863638011408 Magnesium ion binding site [ion binding]; other site 863638011409 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 863638011410 ParB-like nuclease domain; Region: ParBc; pfam02195 863638011411 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 863638011412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638011413 S-adenosylmethionine binding site [chemical binding]; other site 863638011414 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 863638011415 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 863638011416 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 863638011417 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 863638011418 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 863638011419 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 863638011420 trmE is a tRNA modification GTPase; Region: trmE; cd04164 863638011421 G1 box; other site 863638011422 GTP/Mg2+ binding site [chemical binding]; other site 863638011423 Switch I region; other site 863638011424 G2 box; other site 863638011425 Switch II region; other site 863638011426 G3 box; other site 863638011427 G4 box; other site 863638011428 G5 box; other site 863638011429 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 863638011430 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 863638011431 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 863638011432 G-X-X-G motif; other site 863638011433 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 863638011434 RxxxH motif; other site 863638011435 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 863638011436 putative inner membrane protein translocase component YidC; Provisional; Region: PRK00145 863638011437 Haemolytic domain; Region: Haemolytic; pfam01809 863638011438 ribonuclease P; Reviewed; Region: rnpA; PRK00499 863638011439 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 863638011440 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 863638011441 classical (c) SDRs; Region: SDR_c; cd05233 863638011442 NAD(P) binding site [chemical binding]; other site 863638011443 active site 863638011444 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638011445 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638011446 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638011447 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638011448 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 863638011449 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638011450 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638011451 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638011452 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638011453 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638011454 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 863638011455 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 863638011456 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638011457 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638011458 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638011459 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638011460 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638011461 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638011462 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638011463 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638011464 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 863638011465 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638011466 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 863638011467 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 863638011468 Cysteine protease [Posttranslational modification, protein turnover, chaperones]; Region: COG4870 863638011469 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 863638011470 active site 863638011471 Enterocin A Immunity; Region: EntA_Immun; pfam08951 863638011472 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 863638011473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 863638011474 DNA-binding site [nucleotide binding]; DNA binding site 863638011475 UTRA domain; Region: UTRA; pfam07702 863638011476 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 863638011477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 863638011478 active site 863638011479 phosphorylation site [posttranslational modification] 863638011480 dimerization interface [polypeptide binding]; other site 863638011481 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 863638011482 beta-galactosidase; Region: BGL; TIGR03356 863638011483 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 863638011484 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 863638011485 Protein tyrosine phosphatase, catalytic domain motif; Region: PTPc_motif; smart00404 863638011486 active site 863638011487 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 863638011488 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 863638011489 putative active site [active] 863638011490 catalytic site [active] 863638011491 putative metal binding site [ion binding]; other site 863638011492 Predicted membrane protein [Function unknown]; Region: COG4331 863638011493 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 863638011494 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 863638011495 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 863638011496 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 863638011497 Spore germination protein; Region: Spore_permease; cl17796 863638011498 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 863638011499 MarR family; Region: MarR_2; pfam12802 863638011500 MarR family; Region: MarR_2; cl17246 863638011501 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 863638011502 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 863638011503 dimer interface [polypeptide binding]; other site 863638011504 PYR/PP interface [polypeptide binding]; other site 863638011505 TPP binding site [chemical binding]; other site 863638011506 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 863638011507 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 863638011508 TPP-binding site [chemical binding]; other site 863638011509 dimer interface [polypeptide binding]; other site 863638011510 Amino acid permease; Region: AA_permease_2; pfam13520 863638011511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638011512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638011513 WHG domain; Region: WHG; pfam13305 863638011514 drug efflux system protein MdtG; Provisional; Region: PRK09874 863638011515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638011516 putative substrate translocation pore; other site 863638011517 Isochorismatase family; Region: Isochorismatase; pfam00857 863638011518 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 863638011519 catalytic triad [active] 863638011520 conserved cis-peptide bond; other site 863638011521 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 863638011522 dimerization interface [polypeptide binding]; other site 863638011523 putative DNA binding site [nucleotide binding]; other site 863638011524 putative Zn2+ binding site [ion binding]; other site 863638011525 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 863638011526 active site residue [active] 863638011527 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 863638011528 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 863638011529 active site residue [active] 863638011530 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 863638011531 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 863638011532 putative catalytic cysteine [active] 863638011533 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 863638011534 putative active site [active] 863638011535 metal binding site [ion binding]; metal-binding site 863638011536 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 863638011537 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 863638011538 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 863638011539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 863638011540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638011541 non-specific DNA binding site [nucleotide binding]; other site 863638011542 salt bridge; other site 863638011543 sequence-specific DNA binding site [nucleotide binding]; other site 863638011544 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638011545 binding surface 863638011546 TPR motif; other site 863638011547 Tetratricopeptide repeat; Region: TPR_12; pfam13424 863638011548 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 863638011549 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 863638011550 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 863638011551 FAD binding pocket [chemical binding]; other site 863638011552 FAD binding motif [chemical binding]; other site 863638011553 phosphate binding motif [ion binding]; other site 863638011554 beta-alpha-beta structure motif; other site 863638011555 NAD binding pocket [chemical binding]; other site 863638011556 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 863638011557 glycosyltransferase, MGT family; Region: MGT; TIGR01426 863638011558 active site 863638011559 TDP-binding site; other site 863638011560 acceptor substrate-binding pocket; other site 863638011561 homodimer interface [polypeptide binding]; other site 863638011562 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 863638011563 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638011564 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 863638011565 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 863638011566 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 863638011567 dimer interface [polypeptide binding]; other site 863638011568 putative CheW interface [polypeptide binding]; other site 863638011569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638011570 H+ Antiporter protein; Region: 2A0121; TIGR00900 863638011571 putative substrate translocation pore; other site 863638011572 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 863638011573 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 863638011574 substrate binding pocket [chemical binding]; other site 863638011575 catalytic triad [active] 863638011576 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 863638011577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 863638011578 NAD(P) binding site [chemical binding]; other site 863638011579 active site 863638011580 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 863638011581 MarR family; Region: MarR_2; pfam12802 863638011582 Beta-1,4-xylanase [Carbohydrate transport and metabolism]; Region: XynA; COG3693 863638011583 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 863638011584 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 863638011585 putative active site [active] 863638011586 putative metal binding site [ion binding]; other site 863638011587 CAAX protease self-immunity; Region: Abi; pfam02517 863638011588 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 863638011589 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 863638011590 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 863638011591 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 863638011592 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 863638011593 putative active site [active] 863638011594 metal binding site [ion binding]; metal-binding site 863638011595 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 863638011596 Chloramphenicol acetyltransferase; Region: CAT; smart01059 863638011597 manganese transport protein MntH; Reviewed; Region: PRK00701 863638011598 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 863638011599 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 863638011600 putative active site [active] 863638011601 catalytic residue [active] 863638011602 M6 family metalloprotease domain; Region: M6dom_TIGR03296 863638011603 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 863638011604 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 863638011605 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 863638011606 active pocket/dimerization site; other site 863638011607 active site 863638011608 phosphorylation site [posttranslational modification] 863638011609 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 863638011610 active site 863638011611 phosphorylation site [posttranslational modification] 863638011612 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 863638011613 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 863638011614 Domain of unknown function (DUF956); Region: DUF956; pfam06115 863638011615 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 863638011616 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 863638011617 motif II; other site 863638011618 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 863638011619 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 863638011620 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 863638011621 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 863638011622 putative sugar binding sites [chemical binding]; other site 863638011623 Q-X-W motif; other site 863638011624 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 863638011625 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 863638011626 putative active site [active] 863638011627 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 863638011628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638011629 Walker A/P-loop; other site 863638011630 ATP binding site [chemical binding]; other site 863638011631 Q-loop/lid; other site 863638011632 ABC transporter signature motif; other site 863638011633 Walker B; other site 863638011634 D-loop; other site 863638011635 H-loop/switch region; other site 863638011636 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 863638011637 Predicted membrane protein [Function unknown]; Region: COG2323 863638011638 glycosyltransferase; Provisional; Region: PRK13481 863638011639 Transglycosylase; Region: Transgly; pfam00912 863638011640 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 863638011641 putative acyltransferase; Provisional; Region: PRK05790 863638011642 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 863638011643 dimer interface [polypeptide binding]; other site 863638011644 active site 863638011645 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638011646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638011647 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 863638011648 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 863638011649 active site 863638011650 DNA binding site [nucleotide binding] 863638011651 Int/Topo IB signature motif; other site 863638011652 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 863638011653 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 863638011654 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 863638011655 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 863638011656 ligand binding site [chemical binding]; other site 863638011657 flexible hinge region; other site 863638011658 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 863638011659 putative switch regulator; other site 863638011660 non-specific DNA interactions [nucleotide binding]; other site 863638011661 DNA binding site [nucleotide binding] 863638011662 sequence specific DNA binding site [nucleotide binding]; other site 863638011663 putative cAMP binding site [chemical binding]; other site 863638011664 Methyltransferase domain; Region: Methyltransf_31; pfam13847 863638011665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 863638011666 S-adenosylmethionine binding site [chemical binding]; other site 863638011667 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 863638011668 Major Facilitator Superfamily; Region: MFS_1; pfam07690 863638011669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638011670 putative substrate translocation pore; other site 863638011671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638011672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638011673 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 863638011674 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 863638011675 dimer interface [polypeptide binding]; other site 863638011676 active site 863638011677 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 863638011678 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 863638011679 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 863638011680 Walker A/P-loop; other site 863638011681 ATP binding site [chemical binding]; other site 863638011682 Q-loop/lid; other site 863638011683 ABC transporter signature motif; other site 863638011684 Walker B; other site 863638011685 D-loop; other site 863638011686 H-loop/switch region; other site 863638011687 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 863638011688 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 863638011689 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 863638011690 Transposase and inactivated derivatives, TnpA family [DNA replication, recombination, and repair]; Region: COG4644 863638011691 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 863638011692 DNA binding site [nucleotide binding] 863638011693 active site 863638011694 Int/Topo IB signature motif; other site 863638011695 Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221 863638011696 dimer interface [polypeptide binding]; other site 863638011697 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 863638011698 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 863638011699 TAP-like protein; Region: Abhydrolase_4; pfam08386 863638011700 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 863638011701 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 863638011702 active site 863638011703 Ca binding site [ion binding]; other site 863638011704 catalytic site [active] 863638011705 Aamy_C domain; Region: Aamy_C; smart00632 863638011706 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 863638011707 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 863638011708 MutS domain III; Region: MutS_III; pfam05192 863638011709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 863638011710 Walker A/P-loop; other site 863638011711 ATP binding site [chemical binding]; other site 863638011712 Q-loop/lid; other site 863638011713 ABC transporter signature motif; other site 863638011714 Walker B; other site 863638011715 D-loop; other site 863638011716 H-loop/switch region; other site 863638011717 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638011718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638011719 Uncharacterized protein involved in formate dehydrogenase formation [Posttranslational modification, protein turnover, chaperones]; Region: FdhE; COG3058 863638011720 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 863638011721 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 863638011722 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 863638011723 dimerization interface [polypeptide binding]; other site 863638011724 putative DNA binding site [nucleotide binding]; other site 863638011725 putative Zn2+ binding site [ion binding]; other site 863638011726 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 863638011727 arsenical-resistance protein; Region: acr3; TIGR00832 863638011728 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 863638011729 Low molecular weight phosphatase family; Region: LMWPc; cd00115 863638011730 active site 863638011731 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 863638011732 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 863638011733 TPP-binding site; other site 863638011734 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 863638011735 PYR/PP interface [polypeptide binding]; other site 863638011736 dimer interface [polypeptide binding]; other site 863638011737 TPP binding site [chemical binding]; other site 863638011738 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 863638011739 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 863638011740 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 863638011741 DNA binding residues [nucleotide binding] 863638011742 putative dimer interface [polypeptide binding]; other site 863638011743 Predicted transcriptional regulators [Transcription]; Region: COG1695 863638011744 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 863638011745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638011746 Major Facilitator Superfamily; Region: MFS_1; pfam07690 863638011747 putative substrate translocation pore; other site 863638011748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638011749 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638011750 Coenzyme A binding pocket [chemical binding]; other site 863638011751 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 863638011752 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 863638011753 Coenzyme A binding pocket [chemical binding]; other site 863638011754 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 863638011755 B3/4 domain; Region: B3_4; pfam03483 863638011756 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 863638011757 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 863638011758 active site 863638011759 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 863638011760 substrate binding site [chemical binding]; other site 863638011761 active site 863638011762 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 863638011763 metal binding site [ion binding]; metal-binding site 863638011764 ligand binding site [chemical binding]; other site 863638011765 Beta-1,4-xylanase [Carbohydrate transport and metabolism]; Region: XynA; COG3693 863638011766 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 863638011767 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 863638011768 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 863638011769 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 863638011770 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 863638011771 putative sugar binding sites [chemical binding]; other site 863638011772 Q-X-W motif; other site 863638011773 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 863638011774 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 863638011775 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 863638011776 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 863638011777 putative sugar binding sites [chemical binding]; other site 863638011778 Q-X-W motif; other site 863638011779 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 863638011780 substrate binding site [chemical binding]; other site 863638011781 active site 863638011782 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 863638011783 metal binding site [ion binding]; metal-binding site 863638011784 ligand binding site [chemical binding]; other site 863638011785 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 863638011786 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 863638011787 putative sugar binding sites [chemical binding]; other site 863638011788 Q-X-W motif; other site 863638011789 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 863638011790 GAF domain; Region: GAF; cl17456 863638011791 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 863638011792 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 863638011793 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 863638011794 NADP binding site [chemical binding]; other site 863638011795 active site 863638011796 putative substrate binding site [chemical binding]; other site 863638011797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638011798 Major Facilitator Superfamily; Region: MFS_1; pfam07690 863638011799 putative substrate translocation pore; other site 863638011800 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 863638011801 Mg binding site [ion binding]; other site 863638011802 nucleotide binding site [chemical binding]; other site 863638011803 putative protofilament interface [polypeptide binding]; other site 863638011804 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 863638011805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 863638011806 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 863638011807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638011808 putative substrate translocation pore; other site 863638011809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638011810 Putative phosphatase regulatory subunit; Region: CBM_21; pfam03370 863638011811 Putative phosphatase regulatory subunit; Region: CBM_21; pfam03370 863638011812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638011813 putative substrate translocation pore; other site 863638011814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 863638011815 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 863638011816 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 863638011817 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 863638011818 active site 863638011819 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 863638011820 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 863638011821 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 863638011822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638011823 Radical SAM superfamily; Region: Radical_SAM; pfam04055 863638011824 FeS/SAM binding site; other site 863638011825 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 863638011826 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 863638011827 acetyl-CoA carboxylase subunit A; Validated; Region: PRK08463 863638011828 phosphoribosylamine--glycine ligase; Region: purD; TIGR00877 863638011829 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 863638011830 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 863638011831 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 863638011832 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 863638011833 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 863638011834 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 863638011835 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 863638011836 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 863638011837 nickel binding site [ion binding]; other site 863638011838 Predicted heme/steroid binding protein [General function prediction only]; Region: COG4892 863638011839 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 863638011840 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 863638011841 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 863638011842 Predicted membrane protein [Function unknown]; Region: COG2323 863638011843 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 863638011844 Zn binding site [ion binding]; other site 863638011845 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 863638011846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 863638011847 non-specific DNA binding site [nucleotide binding]; other site 863638011848 salt bridge; other site 863638011849 sequence-specific DNA binding site [nucleotide binding]; other site 863638011850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638011851 binding surface 863638011852 TPR motif; other site 863638011853 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 863638011854 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 863638011855 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 863638011856 Family description; Region: VCBS; pfam13517 863638011857 Family description; Region: VCBS; pfam13517 863638011858 Family description; Region: VCBS; pfam13517 863638011859 Family description; Region: VCBS; pfam13517 863638011860 Family description; Region: VCBS; pfam13517 863638011861 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 863638011862 catalytic residues [active] 863638011863 Predicted transcriptional regulators [Transcription]; Region: COG1695 863638011864 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 863638011865 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 863638011866 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 863638011867 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638011868 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638011869 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638011870 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 863638011871 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 863638011872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638011873 binding surface 863638011874 TPR motif; other site 863638011875 TPR repeat; Region: TPR_11; pfam13414 863638011876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638011877 binding surface 863638011878 TPR motif; other site 863638011879 Tetratricopeptide repeat; Region: TPR_12; pfam13424 863638011880 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 863638011881 binding surface 863638011882 TPR repeat; Region: TPR_11; pfam13414 863638011883 TPR motif; other site 863638011884 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 863638011885 Coenzyme A acylating aldehyde dehydrogenase (ACDH), Ethanolamine utilization protein EutE, and related proteins; Region: ALDH_F20_ACDH_EutE-like; cd07081 863638011886 putative catalytic cysteine [active] 863638011887 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 863638011888 putative active site [active] 863638011889 metal binding site [ion binding]; metal-binding site 863638011890 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 863638011891 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 863638011892 acetoacetate decarboxylase; Provisional; Region: PRK02265 863638011893 YvrJ protein family; Region: YvrJ; pfam12841 863638011894 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 863638011895 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 863638011896 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 863638011897 DNA binding residues [nucleotide binding] 863638011898 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 863638011899 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 863638011900 active site 863638011901 Ca binding site [ion binding]; other site 863638011902 catalytic site [active] 863638011903 Aamy_C domain; Region: Aamy_C; smart00632 863638011904 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 863638011905 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 863638011906 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 863638011907 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 863638011908 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 863638011909 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 863638011910 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 863638011911 FeS/SAM binding site; other site 863638011912 Uncharacterized conserved protein [Function unknown]; Region: COG2898 863638011913 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 863638011914 Initiator Replication protein; Region: Rep_3; pfam01051 863638011915 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 863638011916 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 863638011917 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 863638011918 P-loop; other site 863638011919 Magnesium ion binding site [ion binding]; other site 863638011920 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 863638011921 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 863638011922 DNA binding residues [nucleotide binding] 863638011923 putative dimer interface [polypeptide binding]; other site