-- dump date 20140619_042934 -- class Genbank::misc_feature -- table misc_feature_note -- id note 498214000001 DNA topoisomerase III; Provisional; Region: PRK07726 498214000002 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 498214000003 active site 498214000004 putative interdomain interaction site [polypeptide binding]; other site 498214000005 putative metal-binding site [ion binding]; other site 498214000006 putative nucleotide binding site [chemical binding]; other site 498214000007 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 498214000008 domain I; other site 498214000009 DNA binding groove [nucleotide binding] 498214000010 phosphate binding site [ion binding]; other site 498214000011 domain II; other site 498214000012 domain III; other site 498214000013 nucleotide binding site [chemical binding]; other site 498214000014 catalytic site [active] 498214000015 domain IV; other site 498214000016 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 498214000017 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 498214000018 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 498214000019 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498214000020 ATP binding site [chemical binding]; other site 498214000021 putative Mg++ binding site [ion binding]; other site 498214000022 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498214000023 nucleotide binding region [chemical binding]; other site 498214000024 ATP-binding site [chemical binding]; other site 498214000025 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 498214000026 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214000027 Zn2+ binding site [ion binding]; other site 498214000028 Mg2+ binding site [ion binding]; other site 498214000029 OB-fold nucleic acid binding domain; Region: tRNA_anti; pfam01336 498214000030 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 498214000031 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498214000032 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 498214000033 Transglycosylase; Region: Transgly; pfam00912 498214000034 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 498214000035 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 498214000036 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 498214000037 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498214000038 Walker A/P-loop; other site 498214000039 ATP binding site [chemical binding]; other site 498214000040 Q-loop/lid; other site 498214000041 ABC transporter signature motif; other site 498214000042 Walker B; other site 498214000043 D-loop; other site 498214000044 H-loop/switch region; other site 498214000045 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 498214000046 nucleotide binding region [chemical binding]; other site 498214000047 helicase superfamily c-terminal domain; Region: HELICc; smart00490 498214000048 ATP-binding site [chemical binding]; other site 498214000049 Methyltransferase domain; Region: Methyltransf_26; pfam13659 498214000050 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 498214000051 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 498214000052 Fic/DOC family; Region: Fic; cl00960 498214000053 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 498214000054 Part of AAA domain; Region: AAA_19; pfam13245 498214000055 Family description; Region: UvrD_C_2; pfam13538 498214000056 Staphylococcal nuclease homologues; Region: SNc; smart00318 498214000057 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 498214000058 Catalytic site; other site 498214000059 Transposase IS200 like; Region: Y1_Tnp; cl00848 498214000060 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 498214000061 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 498214000062 active site 498214000063 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 498214000064 Clostridium P-47 protein; Region: Clostridium_P47; pfam06597 498214000065 Clostridium P-47 protein; Region: Clostridium_P47; pfam06597 498214000066 clostridium toxin-associated regulator BotR; Region: P21_Cbot; TIGR03209 498214000067 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 498214000068 DNA binding residues [nucleotide binding] 498214000069 Clostridium P-47 protein; Region: Clostridium_P47; pfam06597 498214000070 Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742 498214000071 Clostridium neurotoxin, N-terminal receptor binding; Region: Toxin_R_bind_N; pfam07953 498214000072 Nontoxic nonhaemagglutinin C-terminal; Region: NTNH_C; pfam08470 498214000073 Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742 498214000074 Clostridium neurotoxin, Translocation domain; Region: Toxin_trans; pfam07952 498214000075 Clostridium neurotoxin, N-terminal receptor binding; Region: Toxin_R_bind_N; pfam07953 498214000076 Clostridium neurotoxin, C-terminal receptor binding; Region: Toxin_R_bind_C; pfam07951 498214000077 DNA polymerase III DnaE; Validated; Region: dnaE; PRK07135 498214000078 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 498214000079 cyclase homology domain; Region: CHD; cd07302 498214000080 nucleotidyl binding site; other site 498214000081 metal binding site [ion binding]; metal-binding site 498214000082 dimer interface [polypeptide binding]; other site 498214000083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214000084 sequence-specific DNA binding site [nucleotide binding]; other site 498214000085 salt bridge; other site 498214000086 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 498214000087 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 498214000088 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 498214000089 putative active site [active] 498214000090 putative NTP binding site [chemical binding]; other site 498214000091 putative nucleic acid binding site [nucleotide binding]; other site 498214000092 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 498214000093 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 498214000094 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 498214000095 active site 498214000096 YopX protein; Region: YopX; pfam09643 498214000097 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 498214000098 AAA-like domain; Region: AAA_10; pfam12846 498214000099 conjugal transfer ATPase TrbB; Provisional; Region: PRK13894 498214000100 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 498214000101 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 498214000102 dimer interface [polypeptide binding]; other site 498214000103 ssDNA binding site [nucleotide binding]; other site 498214000104 tetramer (dimer of dimers) interface [polypeptide binding]; other site 498214000105 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 498214000106 putative DNA binding surface [nucleotide binding]; other site 498214000107 dimer interface [polypeptide binding]; other site 498214000108 beta-clamp/clamp loader binding surface; other site 498214000109 beta-clamp/translesion DNA polymerase binding surface; other site 498214000110 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 498214000111 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 498214000112 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 498214000113 Methyltransferase domain; Region: Methyltransf_26; pfam13659 498214000114 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 498214000115 linker region; other site 498214000116 AAA-like domain; Region: AAA_10; pfam12846 498214000117 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498214000118 Replication-relaxation; Region: Replic_Relax; pfam13814 498214000119 AAA domain; Region: AAA_21; pfam13304 498214000120 Transposase IS200 like; Region: Y1_Tnp; pfam01797 498214000121 type III secretion system ATPase; Provisional; Region: PRK06315 498214000122 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 498214000123 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 498214000124 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 498214000125 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 498214000126 CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592 498214000127 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 498214000128 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 498214000129 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 498214000130 dimer interface [polypeptide binding]; other site 498214000131 ssDNA binding site [nucleotide binding]; other site 498214000132 tetramer (dimer of dimers) interface [polypeptide binding]; other site 498214000133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 498214000134 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 498214000135 NlpC/P60 family; Region: NLPC_P60; pfam00877 498214000136 LemA family; Region: LemA; cl00742 498214000137 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214000138 Zn2+ binding site [ion binding]; other site 498214000139 Mg2+ binding site [ion binding]; other site 498214000140 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 498214000141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214000142 Walker A motif; other site 498214000143 ATP binding site [chemical binding]; other site 498214000144 Walker B motif; other site 498214000145 arginine finger; other site 498214000146 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 498214000147 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 498214000148 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 498214000149 RRXRR protein; Region: RRXRR; pfam14239 498214000150 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 498214000151 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 498214000152 active site 498214000153 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 498214000154 Protein of unknown function (DUF3832); Region: DUF3832; pfam12909 498214000155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 498214000156 binding surface 498214000157 TPR motif; other site 498214000158 Tetratricopeptide repeat; Region: TPR_12; pfam13424 498214000159 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214000160 Zn2+ binding site [ion binding]; other site 498214000161 Mg2+ binding site [ion binding]; other site 498214000162 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 498214000163 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 498214000164 active site 498214000165 CHC2 zinc finger; Region: zf-CHC2; cl17510 498214000166 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 498214000167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214000168 non-specific DNA binding site [nucleotide binding]; other site 498214000169 salt bridge; other site 498214000170 sequence-specific DNA binding site [nucleotide binding]; other site 498214000171 YopX protein; Region: YopX; pfam09643 498214000172 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 498214000173 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 498214000174 cofactor binding site; other site 498214000175 DNA binding site [nucleotide binding] 498214000176 substrate interaction site [chemical binding]; other site 498214000177 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 498214000178 DNA methylase; Region: N6_N4_Mtase; pfam01555 498214000179 Methyltransferase domain; Region: Methyltransf_25; pfam13649 498214000180 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 498214000181 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 498214000182 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 498214000183 Stage III sporulation protein D; Region: SpoIIID; pfam12116 498214000184 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 498214000185 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 498214000186 Mg binding site [ion binding]; other site 498214000187 nucleotide binding site [chemical binding]; other site 498214000188 putative protofilament interface [polypeptide binding]; other site 498214000189 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 498214000190 Bax inhibitor 1 like; Region: BaxI_1; cl17691 498214000191 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 498214000192 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 498214000193 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 498214000194 active site 498214000195 metal binding site [ion binding]; metal-binding site 498214000196 YopX protein; Region: YopX; cl09859 498214000197 DNA polymerase II large subunit; Provisional; Region: PRK14714 498214000198 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214000199 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214000200 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214000201 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 498214000202 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 498214000203 Probable transposase; Region: OrfB_IS605; pfam01385 498214000204 Transposase IS200 like; Region: Y1_Tnp; cl00848 498214000205 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 498214000206 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 498214000207 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 498214000208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214000209 Walker A motif; other site 498214000210 ATP binding site [chemical binding]; other site 498214000211 Walker B motif; other site 498214000212 arginine finger; other site 498214000213 Peptidase family M41; Region: Peptidase_M41; pfam01434 498214000214 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 498214000215 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 498214000216 Walker A motif; other site 498214000217 ATP binding site [chemical binding]; other site 498214000218 Walker B motif; other site 498214000219 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 498214000220 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 498214000221 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 498214000222 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 498214000223 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 498214000224 replicative DNA helicase; Region: DnaB; TIGR00665 498214000225 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 498214000226 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 498214000227 Walker A motif; other site 498214000228 ATP binding site [chemical binding]; other site 498214000229 Walker B motif; other site 498214000230 DNA binding loops [nucleotide binding] 498214000231 hypothetical protein; Validated; Region: PRK08116 498214000232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214000233 Walker A motif; other site 498214000234 ATP binding site [chemical binding]; other site 498214000235 Walker B motif; other site 498214000236 Helix-turn-helix domain; Region: HTH_36; pfam13730 498214000237 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 498214000238 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498214000239 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 498214000240 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 498214000241 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498214000242 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 498214000243 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 498214000244 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 498214000245 RNA binding site [nucleotide binding]; other site 498214000246 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 498214000247 RNA binding site [nucleotide binding]; other site 498214000248 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498214000249 AAA-like domain; Region: AAA_10; pfam12846 498214000250 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 498214000251 Walker A motif; other site 498214000252 ATP binding site [chemical binding]; other site 498214000253 Walker B motif; other site 498214000254 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 498214000255 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 498214000256 Walker A motif; other site 498214000257 ATP binding site [chemical binding]; other site 498214000258 Walker B motif; other site 498214000259 plasmid segregation protein ParM; Provisional; Region: PRK13917 498214000260 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 498214000261 Mg binding site [ion binding]; other site 498214000262 nucleotide binding site [chemical binding]; other site 498214000263 putative protofilament interface [polypeptide binding]; other site 498214000264 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 498214000265 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 498214000266 Stage III sporulation protein D; Region: SpoIIID; cl17560 498214000267 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 498214000268 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 498214000269 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 498214000270 Walker A motif; other site 498214000271 ATP binding site [chemical binding]; other site 498214000272 Walker B motif; other site 498214000273 AAA domain; Region: AAA_31; pfam13614 498214000274 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498214000275 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 498214000276 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 498214000277 N-acetyl-D-glucosamine binding site [chemical binding]; other site 498214000278 catalytic residue [active] 498214000279 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 498214000280 NlpC/P60 family; Region: NLPC_P60; pfam00877 498214000281 AAA-like domain; Region: AAA_10; pfam12846 498214000282 Domain of unknown function DUF87; Region: DUF87; pfam01935 498214000283 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 498214000284 PrgI family protein; Region: PrgI; pfam12666 498214000285 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 498214000286 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498214000287 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 498214000288 PcfJ-like protein; Region: PcfJ; pfam14284 498214000289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214000290 Walker A/P-loop; other site 498214000291 ATP binding site [chemical binding]; other site 498214000292 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 498214000293 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 498214000294 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 498214000295 DnaA N-terminal domain; Region: DnaA_N; pfam11638 498214000296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214000297 Walker A motif; other site 498214000298 ATP binding site [chemical binding]; other site 498214000299 Walker B motif; other site 498214000300 arginine finger; other site 498214000301 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 498214000302 DnaA box-binding interface [nucleotide binding]; other site 498214000303 DNA polymerase III subunit beta; Validated; Region: PRK05643 498214000304 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 498214000305 putative DNA binding surface [nucleotide binding]; other site 498214000306 dimer interface [polypeptide binding]; other site 498214000307 beta-clamp/clamp loader binding surface; other site 498214000308 beta-clamp/translesion DNA polymerase binding surface; other site 498214000309 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 498214000310 RNA binding surface [nucleotide binding]; other site 498214000311 recombination protein F; Reviewed; Region: recF; PRK00064 498214000312 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 498214000313 Walker A/P-loop; other site 498214000314 ATP binding site [chemical binding]; other site 498214000315 Q-loop/lid; other site 498214000316 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214000317 ABC transporter signature motif; other site 498214000318 Walker B; other site 498214000319 D-loop; other site 498214000320 H-loop/switch region; other site 498214000321 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 498214000322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214000323 Mg2+ binding site [ion binding]; other site 498214000324 G-X-G motif; other site 498214000325 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 498214000326 anchoring element; other site 498214000327 dimer interface [polypeptide binding]; other site 498214000328 ATP binding site [chemical binding]; other site 498214000329 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 498214000330 active site 498214000331 putative metal-binding site [ion binding]; other site 498214000332 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 498214000333 DNA gyrase subunit A; Validated; Region: PRK05560 498214000334 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 498214000335 CAP-like domain; other site 498214000336 active site 498214000337 primary dimer interface [polypeptide binding]; other site 498214000338 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 498214000339 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 498214000340 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 498214000341 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 498214000342 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 498214000343 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 498214000344 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 498214000345 HTH domain; Region: HTH_11; pfam08279 498214000346 3H domain; Region: 3H; pfam02829 498214000347 Uncharacterized conserved protein [Function unknown]; Region: COG2006 498214000348 Domain of unknown function (DUF362); Region: DUF362; pfam04015 498214000349 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 498214000350 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 498214000351 hypothetical protein; Validated; Region: PRK00068 498214000352 Uncharacterized conserved protein [Function unknown]; Region: COG1615 498214000353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 498214000354 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 498214000355 Predicted dehydrogenase [General function prediction only]; Region: COG0579 498214000356 hydroxyglutarate oxidase; Provisional; Region: PRK11728 498214000357 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 498214000358 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 498214000359 seryl-tRNA synthetase; Provisional; Region: PRK05431 498214000360 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 498214000361 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 498214000362 dimer interface [polypeptide binding]; other site 498214000363 active site 498214000364 motif 1; other site 498214000365 motif 2; other site 498214000366 motif 3; other site 498214000367 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 498214000368 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 498214000369 ABC1 family; Region: ABC1; cl17513 498214000370 Uncharacterized conserved protein [Function unknown]; Region: COG3937 498214000371 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 498214000372 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 498214000373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214000374 Walker A motif; other site 498214000375 ATP binding site [chemical binding]; other site 498214000376 Walker B motif; other site 498214000377 arginine finger; other site 498214000378 methionine gamma-lyase; Provisional; Region: PRK06234 498214000379 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 498214000380 homodimer interface [polypeptide binding]; other site 498214000381 substrate-cofactor binding pocket; other site 498214000382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214000383 catalytic residue [active] 498214000384 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 498214000385 nucleoside/Zn binding site; other site 498214000386 dimer interface [polypeptide binding]; other site 498214000387 catalytic motif [active] 498214000388 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 498214000389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214000390 Walker A motif; other site 498214000391 ATP binding site [chemical binding]; other site 498214000392 Walker B motif; other site 498214000393 arginine finger; other site 498214000394 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 498214000395 hypothetical protein; Validated; Region: PRK00153 498214000396 recombination protein RecR; Reviewed; Region: recR; PRK00076 498214000397 RecR protein; Region: RecR; pfam02132 498214000398 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 498214000399 putative active site [active] 498214000400 putative metal-binding site [ion binding]; other site 498214000401 tetramer interface [polypeptide binding]; other site 498214000402 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 498214000403 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 498214000404 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 498214000405 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 498214000406 putative NADH binding site [chemical binding]; other site 498214000407 putative active site [active] 498214000408 nudix motif; other site 498214000409 putative metal binding site [ion binding]; other site 498214000410 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 498214000411 Flavodoxin domain; Region: Flavodoxin_5; cl17428 498214000412 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 498214000413 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 498214000414 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 498214000415 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 498214000416 putative ATP binding site [chemical binding]; other site 498214000417 putative substrate interface [chemical binding]; other site 498214000418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498214000419 putative substrate translocation pore; other site 498214000420 Major Facilitator Superfamily; Region: MFS_1; pfam07690 498214000421 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 498214000422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 498214000423 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 498214000424 active site 498214000425 Fe-S cluster binding site [ion binding]; other site 498214000426 RNA polymerase factor sigma-70; Validated; Region: PRK06811 498214000427 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498214000428 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498214000429 DNA binding residues [nucleotide binding] 498214000430 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 498214000431 DltD C-terminal region; Region: DltD_C; pfam04914 498214000432 SurA N-terminal domain; Region: SurA_N_3; cl07813 498214000433 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 498214000434 NAD-dependent deacetylase; Provisional; Region: PRK00481 498214000435 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 498214000436 NAD+ binding site [chemical binding]; other site 498214000437 substrate binding site [chemical binding]; other site 498214000438 Zn binding site [ion binding]; other site 498214000439 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 498214000440 dimer interface [polypeptide binding]; other site 498214000441 catalytic triad [active] 498214000442 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 498214000443 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 498214000444 Cl binding site [ion binding]; other site 498214000445 oligomer interface [polypeptide binding]; other site 498214000446 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 498214000447 amidohydrolase; Region: amidohydrolases; TIGR01891 498214000448 metal binding site [ion binding]; metal-binding site 498214000449 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 498214000450 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 498214000451 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 498214000452 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 498214000453 homodimer interface [polypeptide binding]; other site 498214000454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214000455 catalytic residue [active] 498214000456 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 498214000457 thymidylate kinase; Provisional; Region: PRK13975; cl17243 498214000458 Protein of unknown function (DUF970); Region: DUF970; pfam06153 498214000459 DNA polymerase III subunit delta'; Validated; Region: PRK05564 498214000460 DNA polymerase III subunit delta'; Validated; Region: PRK08485 498214000461 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 498214000462 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 498214000463 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498214000464 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 498214000465 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 498214000466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214000467 S-adenosylmethionine binding site [chemical binding]; other site 498214000468 Predicted methyltransferases [General function prediction only]; Region: COG0313 498214000469 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 498214000470 putative SAM binding site [chemical binding]; other site 498214000471 putative homodimer interface [polypeptide binding]; other site 498214000472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 498214000473 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 498214000474 NlpC/P60 family; Region: NLPC_P60; pfam00877 498214000475 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 498214000476 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 498214000477 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 498214000478 arginine deiminase; Provisional; Region: PRK01388 498214000479 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 498214000480 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 498214000481 homotrimer interaction site [polypeptide binding]; other site 498214000482 zinc binding site [ion binding]; other site 498214000483 CDP-binding sites; other site 498214000484 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 498214000485 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 498214000486 putative active site [active] 498214000487 putative metal binding site [ion binding]; other site 498214000488 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 498214000489 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 498214000490 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 498214000491 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 498214000492 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 498214000493 Fe-S cluster binding site [ion binding]; other site 498214000494 active site 498214000495 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 498214000496 MarR family; Region: MarR_2; cl17246 498214000497 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 498214000498 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 498214000499 active site 498214000500 HIGH motif; other site 498214000501 KMSKS motif; other site 498214000502 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 498214000503 tRNA binding surface [nucleotide binding]; other site 498214000504 anticodon binding site; other site 498214000505 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 498214000506 dimer interface [polypeptide binding]; other site 498214000507 putative tRNA-binding site [nucleotide binding]; other site 498214000508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 498214000509 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 498214000510 active site 498214000511 Domain of unknown function (DUF348); Region: DUF348; pfam03990 498214000512 Domain of unknown function (DUF348); Region: DUF348; pfam03990 498214000513 G5 domain; Region: G5; pfam07501 498214000514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 498214000515 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 498214000516 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 498214000517 putative active site [active] 498214000518 putative metal binding site [ion binding]; other site 498214000519 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 498214000520 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 498214000521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214000522 S-adenosylmethionine binding site [chemical binding]; other site 498214000523 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 498214000524 HlyD family secretion protein; Region: HlyD_3; pfam13437 498214000525 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214000526 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498214000527 Walker A/P-loop; other site 498214000528 ATP binding site [chemical binding]; other site 498214000529 Q-loop/lid; other site 498214000530 ABC transporter signature motif; other site 498214000531 Walker B; other site 498214000532 D-loop; other site 498214000533 H-loop/switch region; other site 498214000534 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 498214000535 FtsX-like permease family; Region: FtsX; pfam02687 498214000536 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 498214000537 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498214000538 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 498214000539 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 498214000540 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 498214000541 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 498214000542 metal binding site [ion binding]; metal-binding site 498214000543 active site 498214000544 I-site; other site 498214000545 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 498214000546 MgtC family; Region: MgtC; pfam02308 498214000547 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 498214000548 ATP cone domain; Region: ATP-cone; pfam03477 498214000549 Class III ribonucleotide reductase; Region: RNR_III; cd01675 498214000550 effector binding site; other site 498214000551 active site 498214000552 Zn binding site [ion binding]; other site 498214000553 glycine loop; other site 498214000554 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 498214000555 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 498214000556 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 498214000557 Predicted transcriptional regulators [Transcription]; Region: COG1695 498214000558 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 498214000559 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 498214000560 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 498214000561 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 498214000562 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 498214000563 HIGH motif; other site 498214000564 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 498214000565 active site 498214000566 KMSKS motif; other site 498214000567 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 498214000568 tRNA binding surface [nucleotide binding]; other site 498214000569 anticodon binding site; other site 498214000570 Transcriptional regulators [Transcription]; Region: PurR; COG1609 498214000571 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 498214000572 DNA binding site [nucleotide binding] 498214000573 domain linker motif; other site 498214000574 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 498214000575 AAA domain; Region: AAA_11; pfam13086 498214000576 Part of AAA domain; Region: AAA_19; pfam13245 498214000577 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 498214000578 AAA domain; Region: AAA_12; pfam13087 498214000579 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 498214000580 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 498214000581 Substrate binding site; other site 498214000582 Cupin domain; Region: Cupin_2; cl17218 498214000583 hypothetical protein; Provisional; Region: PRK04194 498214000584 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 498214000585 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 498214000586 Ligand Binding Site [chemical binding]; other site 498214000587 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 498214000588 AIR carboxylase; Region: AIRC; smart01001 498214000589 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 498214000590 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214000591 FeS/SAM binding site; other site 498214000592 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 498214000593 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 498214000594 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 498214000595 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 498214000596 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 498214000597 active site 498214000598 ATP binding site [chemical binding]; other site 498214000599 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 498214000600 substrate binding site [chemical binding]; other site 498214000601 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 498214000602 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 498214000603 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 498214000604 substrate binding site [chemical binding]; other site 498214000605 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 498214000606 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 498214000607 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 498214000608 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 498214000609 active site 498214000610 ATP binding site [chemical binding]; other site 498214000611 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 498214000612 substrate binding site [chemical binding]; other site 498214000613 YabG peptidase U57; Region: Peptidase_U57; pfam05582 498214000614 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 498214000615 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 498214000616 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 498214000617 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 498214000618 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 498214000619 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498214000620 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 498214000621 proposed catalytic triad [active] 498214000622 active site nucleophile [active] 498214000623 cyanophycin synthetase; Provisional; Region: PRK14016 498214000624 ATP-grasp domain; Region: ATP-grasp_4; cl17255 498214000625 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 498214000626 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 498214000627 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 498214000628 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 498214000629 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 498214000630 Spore germination protein; Region: Spore_permease; cl17796 498214000631 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 498214000632 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 498214000633 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 498214000634 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 498214000635 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 498214000636 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 498214000637 germination protein YpeB; Region: spore_YpeB; TIGR02889 498214000638 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 498214000639 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 498214000640 Ligand Binding Site [chemical binding]; other site 498214000641 Domain of unknown function (DUF814); Region: DUF814; pfam05670 498214000642 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 498214000643 CTP synthetase; Validated; Region: pyrG; PRK05380 498214000644 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 498214000645 Catalytic site [active] 498214000646 active site 498214000647 UTP binding site [chemical binding]; other site 498214000648 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 498214000649 active site 498214000650 putative oxyanion hole; other site 498214000651 catalytic triad [active] 498214000652 transcription termination factor Rho; Provisional; Region: rho; PRK09376 498214000653 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 498214000654 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 498214000655 RNA binding site [nucleotide binding]; other site 498214000656 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 498214000657 Walker A motif; other site 498214000658 ATP binding site [chemical binding]; other site 498214000659 Walker B motif; other site 498214000660 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 498214000661 thymidine kinase; Provisional; Region: PRK04296 498214000662 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 498214000663 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 498214000664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214000665 peptide chain release factor 1; Validated; Region: prfA; PRK00591 498214000666 This domain is found in peptide chain release factors; Region: PCRF; smart00937 498214000667 RF-1 domain; Region: RF-1; pfam00472 498214000668 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 498214000669 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 498214000670 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 498214000671 Low molecular weight phosphatase family; Region: LMWPc; cd00115 498214000672 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 498214000673 active site 498214000674 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 498214000675 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498214000676 active site 498214000677 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 498214000678 active site 498214000679 Zn binding site [ion binding]; other site 498214000680 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 498214000681 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 498214000682 Mg++ binding site [ion binding]; other site 498214000683 putative catalytic motif [active] 498214000684 substrate binding site [chemical binding]; other site 498214000685 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 498214000686 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 498214000687 active site 498214000688 homodimer interface [polypeptide binding]; other site 498214000689 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 498214000690 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 498214000691 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 498214000692 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 498214000693 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 498214000694 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 498214000695 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 498214000696 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 498214000697 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 498214000698 beta subunit interaction interface [polypeptide binding]; other site 498214000699 Walker A motif; other site 498214000700 ATP binding site [chemical binding]; other site 498214000701 Walker B motif; other site 498214000702 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 498214000703 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 498214000704 core domain interface [polypeptide binding]; other site 498214000705 delta subunit interface [polypeptide binding]; other site 498214000706 epsilon subunit interface [polypeptide binding]; other site 498214000707 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 498214000708 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 498214000709 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 498214000710 alpha subunit interaction interface [polypeptide binding]; other site 498214000711 Walker A motif; other site 498214000712 ATP binding site [chemical binding]; other site 498214000713 Walker B motif; other site 498214000714 inhibitor binding site; inhibition site 498214000715 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 498214000716 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450 498214000717 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 498214000718 gamma subunit interface [polypeptide binding]; other site 498214000719 epsilon subunit interface [polypeptide binding]; other site 498214000720 LBP interface [polypeptide binding]; other site 498214000721 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 498214000722 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 498214000723 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 498214000724 hinge; other site 498214000725 active site 498214000726 stage II sporulation protein D; Region: spore_II_D; TIGR02870 498214000727 Stage II sporulation protein; Region: SpoIID; pfam08486 498214000728 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 498214000729 Peptidase family M23; Region: Peptidase_M23; pfam01551 498214000730 Stage III sporulation protein D; Region: SpoIIID; pfam12116 498214000731 rod shape-determining protein Mbl; Provisional; Region: PRK13928 498214000732 MreB and similar proteins; Region: MreB_like; cd10225 498214000733 nucleotide binding site [chemical binding]; other site 498214000734 Mg binding site [ion binding]; other site 498214000735 putative protofilament interaction site [polypeptide binding]; other site 498214000736 RodZ interaction site [polypeptide binding]; other site 498214000737 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 498214000738 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 498214000739 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 498214000740 Ligand Binding Site [chemical binding]; other site 498214000741 S-adenosylmethionine synthetase; Validated; Region: PRK05250 498214000742 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 498214000743 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 498214000744 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 498214000745 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 498214000746 AAA domain; Region: AAA_30; pfam13604 498214000747 Family description; Region: UvrD_C_2; pfam13538 498214000748 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 498214000749 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 498214000750 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498214000751 active site 498214000752 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 498214000753 30S subunit binding site; other site 498214000754 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 498214000755 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 498214000756 ATP binding site [chemical binding]; other site 498214000757 putative Mg++ binding site [ion binding]; other site 498214000758 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 498214000759 SEC-C motif; Region: SEC-C; pfam02810 498214000760 peptide chain release factor 2; Provisional; Region: PRK05589 498214000761 PCRF domain; Region: PCRF; pfam03462 498214000762 RF-1 domain; Region: RF-1; pfam00472 498214000763 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 498214000764 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 498214000765 Peptidase family M28; Region: Peptidase_M28; pfam04389 498214000766 metal binding site [ion binding]; metal-binding site 498214000767 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 498214000768 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 498214000769 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 498214000770 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 498214000771 RNA binding site [nucleotide binding]; other site 498214000772 Predicted membrane protein [Function unknown]; Region: COG3601 498214000773 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 498214000774 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 498214000775 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 498214000776 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 498214000777 putative active site [active] 498214000778 putative metal binding site [ion binding]; other site 498214000779 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 498214000780 dimerization interface [polypeptide binding]; other site 498214000781 putative DNA binding site [nucleotide binding]; other site 498214000782 putative Zn2+ binding site [ion binding]; other site 498214000783 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 498214000784 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 498214000785 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 498214000786 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 498214000787 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 498214000788 active site residue [active] 498214000789 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 498214000790 CPxP motif; other site 498214000791 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 498214000792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 498214000793 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 498214000794 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 498214000795 synthetase active site [active] 498214000796 NTP binding site [chemical binding]; other site 498214000797 metal binding site [ion binding]; metal-binding site 498214000798 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 498214000799 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 498214000800 HIGH motif; other site 498214000801 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 498214000802 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 498214000803 active site 498214000804 KMSKS motif; other site 498214000805 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 498214000806 tRNA binding surface [nucleotide binding]; other site 498214000807 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 498214000808 active site residue [active] 498214000809 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 498214000810 HSP70 interaction site [polypeptide binding]; other site 498214000811 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 498214000812 putative active site [active] 498214000813 putative triphosphate binding site [ion binding]; other site 498214000814 dimer interface [polypeptide binding]; other site 498214000815 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 498214000816 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 498214000817 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 498214000818 intersubunit interface [polypeptide binding]; other site 498214000819 active site 498214000820 zinc binding site [ion binding]; other site 498214000821 Na+ binding site [ion binding]; other site 498214000822 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 498214000823 Predicted membrane protein [Function unknown]; Region: COG2323 498214000824 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 498214000825 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 498214000826 active site 498214000827 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 498214000828 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 498214000829 FOG: CBS domain [General function prediction only]; Region: COG0517 498214000830 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 498214000831 putative lipid kinase; Reviewed; Region: PRK13059 498214000832 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 498214000833 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 498214000834 hypothetical protein; Provisional; Region: PRK00955 498214000835 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 498214000836 PRC-barrel domain; Region: PRC; pfam05239 498214000837 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 498214000838 MgtE intracellular N domain; Region: MgtE_N; smart00924 498214000839 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 498214000840 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 498214000841 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 498214000842 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 498214000843 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 498214000844 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 498214000845 dimer interface [polypeptide binding]; other site 498214000846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214000847 catalytic residue [active] 498214000848 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 498214000849 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 498214000850 trimer interface [polypeptide binding]; other site 498214000851 active site 498214000852 substrate binding site [chemical binding]; other site 498214000853 CoA binding site [chemical binding]; other site 498214000854 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 498214000855 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 498214000856 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 498214000857 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 498214000858 putative acyl-acceptor binding pocket; other site 498214000859 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 498214000860 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 498214000861 minor groove reading motif; other site 498214000862 helix-hairpin-helix signature motif; other site 498214000863 substrate binding pocket [chemical binding]; other site 498214000864 active site 498214000865 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 498214000866 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 498214000867 Malic enzyme, N-terminal domain; Region: malic; pfam00390 498214000868 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 498214000869 putative NAD(P) binding site [chemical binding]; other site 498214000870 competence damage-inducible protein A; Provisional; Region: PRK00549 498214000871 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 498214000872 putative MPT binding site; other site 498214000873 Competence-damaged protein; Region: CinA; pfam02464 498214000874 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 498214000875 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 498214000876 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 498214000877 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 498214000878 putative oligomer interface [polypeptide binding]; other site 498214000879 putative active site [active] 498214000880 metal binding site [ion binding]; metal-binding site 498214000881 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 498214000882 VanW like protein; Region: VanW; pfam04294 498214000883 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 498214000884 VanW like protein; Region: VanW; pfam04294 498214000885 G5 domain; Region: G5; pfam07501 498214000886 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 498214000887 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214000888 FeS/SAM binding site; other site 498214000889 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 498214000890 EDD domain protein, DegV family; Region: DegV; TIGR00762 498214000891 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 498214000892 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 498214000893 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 498214000894 ligand binding site [chemical binding]; other site 498214000895 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 498214000896 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 498214000897 Walker A/P-loop; other site 498214000898 ATP binding site [chemical binding]; other site 498214000899 Q-loop/lid; other site 498214000900 ABC transporter signature motif; other site 498214000901 Walker B; other site 498214000902 D-loop; other site 498214000903 H-loop/switch region; other site 498214000904 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 498214000905 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 498214000906 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 498214000907 TM-ABC transporter signature motif; other site 498214000908 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 498214000909 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 498214000910 TM-ABC transporter signature motif; other site 498214000911 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 498214000912 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 498214000913 NodB motif; other site 498214000914 active site 498214000915 catalytic site [active] 498214000916 Zn binding site [ion binding]; other site 498214000917 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 498214000918 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 498214000919 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 498214000920 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 498214000921 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 498214000922 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 498214000923 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 498214000924 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 498214000925 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 498214000926 Phosphoglycerate kinase; Region: PGK; pfam00162 498214000927 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 498214000928 substrate binding site [chemical binding]; other site 498214000929 hinge regions; other site 498214000930 ADP binding site [chemical binding]; other site 498214000931 catalytic site [active] 498214000932 triosephosphate isomerase; Provisional; Region: PRK14567 498214000933 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 498214000934 substrate binding site [chemical binding]; other site 498214000935 dimer interface [polypeptide binding]; other site 498214000936 catalytic triad [active] 498214000937 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 498214000938 phosphoglyceromutase; Provisional; Region: PRK05434 498214000939 enolase; Provisional; Region: eno; PRK00077 498214000940 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 498214000941 dimer interface [polypeptide binding]; other site 498214000942 metal binding site [ion binding]; metal-binding site 498214000943 substrate binding pocket [chemical binding]; other site 498214000944 Preprotein translocase SecG subunit; Region: SecG; pfam03840 498214000945 ribonuclease R; Region: RNase_R; TIGR02063 498214000946 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 498214000947 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 498214000948 RNB domain; Region: RNB; pfam00773 498214000949 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 498214000950 RNA binding site [nucleotide binding]; other site 498214000951 stationary phase survival protein SurE; Provisional; Region: PRK13933 498214000952 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 498214000953 SmpB-tmRNA interface; other site 498214000954 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 498214000955 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 498214000956 MepB protein; Region: MepB; pfam08877 498214000957 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 498214000958 FAD binding domain; Region: FAD_binding_4; pfam01565 498214000959 Berberine and berberine like; Region: BBE; pfam08031 498214000960 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 498214000961 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 498214000962 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498214000963 catalytic residue [active] 498214000964 flagellin; Provisional; Region: PRK12804 498214000965 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 498214000966 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 498214000967 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 498214000968 active site 498214000969 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 498214000970 lysine transporter; Provisional; Region: PRK10836 498214000971 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498214000972 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 498214000973 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 498214000974 trimer interface [polypeptide binding]; other site 498214000975 active site 498214000976 substrate binding site [chemical binding]; other site 498214000977 CoA binding site [chemical binding]; other site 498214000978 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 498214000979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214000980 Coenzyme A binding pocket [chemical binding]; other site 498214000981 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 498214000982 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 498214000983 active site 498214000984 catalytic site [active] 498214000985 substrate binding site [chemical binding]; other site 498214000986 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 498214000987 Dimer interface [polypeptide binding]; other site 498214000988 BRCT sequence motif; other site 498214000989 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214000990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214000991 active site 498214000992 phosphorylation site [posttranslational modification] 498214000993 intermolecular recognition site; other site 498214000994 dimerization interface [polypeptide binding]; other site 498214000995 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214000996 DNA binding site [nucleotide binding] 498214000997 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214000998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214000999 dimer interface [polypeptide binding]; other site 498214001000 phosphorylation site [posttranslational modification] 498214001001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214001002 ATP binding site [chemical binding]; other site 498214001003 Mg2+ binding site [ion binding]; other site 498214001004 G-X-G motif; other site 498214001005 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 498214001006 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214001007 Walker A/P-loop; other site 498214001008 ATP binding site [chemical binding]; other site 498214001009 Q-loop/lid; other site 498214001010 ABC transporter signature motif; other site 498214001011 Walker B; other site 498214001012 D-loop; other site 498214001013 H-loop/switch region; other site 498214001014 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 498214001015 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 498214001016 Isochorismatase family; Region: Isochorismatase; pfam00857 498214001017 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 498214001018 catalytic triad [active] 498214001019 conserved cis-peptide bond; other site 498214001020 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 498214001021 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 498214001022 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 498214001023 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 498214001024 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 498214001025 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 498214001026 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 498214001027 catalytic loop [active] 498214001028 iron binding site [ion binding]; other site 498214001029 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 498214001030 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 498214001031 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 498214001032 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 498214001033 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 498214001034 catalytic residues [active] 498214001035 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 498214001036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214001037 active site 498214001038 phosphorylation site [posttranslational modification] 498214001039 intermolecular recognition site; other site 498214001040 dimerization interface [polypeptide binding]; other site 498214001041 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214001042 DNA binding site [nucleotide binding] 498214001043 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214001044 HAMP domain; Region: HAMP; pfam00672 498214001045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214001046 dimer interface [polypeptide binding]; other site 498214001047 phosphorylation site [posttranslational modification] 498214001048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214001049 ATP binding site [chemical binding]; other site 498214001050 Mg2+ binding site [ion binding]; other site 498214001051 G-X-G motif; other site 498214001052 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 498214001053 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 498214001054 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 498214001055 active site 498214001056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498214001057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498214001058 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 498214001059 Beta-lactamase; Region: Beta-lactamase; pfam00144 498214001060 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214001061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214001062 active site 498214001063 phosphorylation site [posttranslational modification] 498214001064 intermolecular recognition site; other site 498214001065 dimerization interface [polypeptide binding]; other site 498214001066 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214001067 DNA binding site [nucleotide binding] 498214001068 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214001069 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214001070 dimerization interface [polypeptide binding]; other site 498214001071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214001072 dimer interface [polypeptide binding]; other site 498214001073 phosphorylation site [posttranslational modification] 498214001074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214001075 ATP binding site [chemical binding]; other site 498214001076 Mg2+ binding site [ion binding]; other site 498214001077 G-X-G motif; other site 498214001078 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 498214001079 FAD binding domain; Region: FAD_binding_4; pfam01565 498214001080 Berberine and berberine like; Region: BBE; pfam08031 498214001081 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 498214001082 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 498214001083 NAD binding site [chemical binding]; other site 498214001084 sugar binding site [chemical binding]; other site 498214001085 divalent metal binding site [ion binding]; other site 498214001086 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 498214001087 dimer interface [polypeptide binding]; other site 498214001088 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 498214001089 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 498214001090 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 498214001091 active site turn [active] 498214001092 phosphorylation site [posttranslational modification] 498214001093 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 498214001094 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 498214001095 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 498214001096 putative active site [active] 498214001097 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 498214001098 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 498214001099 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 498214001100 putative active site [active] 498214001101 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 498214001102 HPr interaction site; other site 498214001103 glycerol kinase (GK) interaction site [polypeptide binding]; other site 498214001104 active site 498214001105 phosphorylation site [posttranslational modification] 498214001106 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214001107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214001108 active site 498214001109 phosphorylation site [posttranslational modification] 498214001110 intermolecular recognition site; other site 498214001111 dimerization interface [polypeptide binding]; other site 498214001112 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214001113 DNA binding site [nucleotide binding] 498214001114 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214001115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214001116 ATP binding site [chemical binding]; other site 498214001117 Mg2+ binding site [ion binding]; other site 498214001118 G-X-G motif; other site 498214001119 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214001120 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498214001121 Walker A/P-loop; other site 498214001122 ATP binding site [chemical binding]; other site 498214001123 Q-loop/lid; other site 498214001124 ABC transporter signature motif; other site 498214001125 Walker B; other site 498214001126 D-loop; other site 498214001127 H-loop/switch region; other site 498214001128 alanine racemase; Reviewed; Region: alr; PRK00053 498214001129 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 498214001130 active site 498214001131 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 498214001132 dimer interface [polypeptide binding]; other site 498214001133 substrate binding site [chemical binding]; other site 498214001134 catalytic residues [active] 498214001135 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 498214001136 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 498214001137 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 498214001138 active site turn [active] 498214001139 phosphorylation site [posttranslational modification] 498214001140 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 498214001141 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 498214001142 NAD binding site [chemical binding]; other site 498214001143 sugar binding site [chemical binding]; other site 498214001144 divalent metal binding site [ion binding]; other site 498214001145 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 498214001146 dimer interface [polypeptide binding]; other site 498214001147 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 498214001148 HPr interaction site; other site 498214001149 glycerol kinase (GK) interaction site [polypeptide binding]; other site 498214001150 active site 498214001151 phosphorylation site [posttranslational modification] 498214001152 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 498214001153 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 498214001154 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 498214001155 putative active site [active] 498214001156 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 498214001157 DNA-binding site [nucleotide binding]; DNA binding site 498214001158 RNA-binding motif; other site 498214001159 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 498214001160 Predicted transcriptional regulator [Transcription]; Region: COG1959 498214001161 Transcriptional regulator; Region: Rrf2; pfam02082 498214001162 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 498214001163 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 498214001164 catalytic residues [active] 498214001165 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 498214001166 NADH(P)-binding; Region: NAD_binding_10; pfam13460 498214001167 NAD binding site [chemical binding]; other site 498214001168 substrate binding site [chemical binding]; other site 498214001169 putative active site [active] 498214001170 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 498214001171 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 498214001172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214001173 dimer interface [polypeptide binding]; other site 498214001174 conserved gate region; other site 498214001175 putative PBP binding loops; other site 498214001176 ABC-ATPase subunit interface; other site 498214001177 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 498214001178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214001179 dimer interface [polypeptide binding]; other site 498214001180 conserved gate region; other site 498214001181 putative PBP binding loops; other site 498214001182 ABC-ATPase subunit interface; other site 498214001183 Uroporphyrinogen decarboxylase (URO-D); Region: URO-D; pfam01208 498214001184 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 498214001185 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 498214001186 Walker A/P-loop; other site 498214001187 ATP binding site [chemical binding]; other site 498214001188 Q-loop/lid; other site 498214001189 ABC transporter signature motif; other site 498214001190 Walker B; other site 498214001191 D-loop; other site 498214001192 H-loop/switch region; other site 498214001193 TOBE domain; Region: TOBE_2; pfam08402 498214001194 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 498214001195 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 498214001196 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 498214001197 putative active site [active] 498214001198 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 498214001199 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 498214001200 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 498214001201 active site turn [active] 498214001202 phosphorylation site [posttranslational modification] 498214001203 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 498214001204 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 498214001205 NAD binding site [chemical binding]; other site 498214001206 sugar binding site [chemical binding]; other site 498214001207 divalent metal binding site [ion binding]; other site 498214001208 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 498214001209 dimer interface [polypeptide binding]; other site 498214001210 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 498214001211 HPr interaction site; other site 498214001212 glycerol kinase (GK) interaction site [polypeptide binding]; other site 498214001213 active site 498214001214 phosphorylation site [posttranslational modification] 498214001215 Dehydratase family; Region: ILVD_EDD; pfam00920 498214001216 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 498214001217 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 498214001218 active site 498214001219 intersubunit interface [polypeptide binding]; other site 498214001220 catalytic residue [active] 498214001221 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 498214001222 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 498214001223 substrate binding site [chemical binding]; other site 498214001224 ATP binding site [chemical binding]; other site 498214001225 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 498214001226 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 498214001227 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 498214001228 active site 498214001229 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 498214001230 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214001231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214001232 active site 498214001233 phosphorylation site [posttranslational modification] 498214001234 intermolecular recognition site; other site 498214001235 dimerization interface [polypeptide binding]; other site 498214001236 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214001237 DNA binding site [nucleotide binding] 498214001238 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214001239 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214001240 dimerization interface [polypeptide binding]; other site 498214001241 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214001242 dimer interface [polypeptide binding]; other site 498214001243 phosphorylation site [posttranslational modification] 498214001244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214001245 ATP binding site [chemical binding]; other site 498214001246 Mg2+ binding site [ion binding]; other site 498214001247 G-X-G motif; other site 498214001248 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 498214001249 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 498214001250 Ligand binding site; other site 498214001251 Putative Catalytic site; other site 498214001252 DXD motif; other site 498214001253 Predicted membrane protein [Function unknown]; Region: COG2246 498214001254 GtrA-like protein; Region: GtrA; pfam04138 498214001255 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 498214001256 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 498214001257 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 498214001258 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214001259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214001260 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 498214001261 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 498214001262 intersubunit interface [polypeptide binding]; other site 498214001263 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 498214001264 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 498214001265 ABC-ATPase subunit interface; other site 498214001266 dimer interface [polypeptide binding]; other site 498214001267 putative PBP binding regions; other site 498214001268 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 498214001269 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 498214001270 Walker A/P-loop; other site 498214001271 ATP binding site [chemical binding]; other site 498214001272 Q-loop/lid; other site 498214001273 ABC transporter signature motif; other site 498214001274 Walker B; other site 498214001275 D-loop; other site 498214001276 H-loop/switch region; other site 498214001277 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 498214001278 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 498214001279 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 498214001280 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214001281 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 498214001282 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 498214001283 intersubunit interface [polypeptide binding]; other site 498214001284 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 498214001285 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 498214001286 ABC-ATPase subunit interface; other site 498214001287 dimer interface [polypeptide binding]; other site 498214001288 putative PBP binding regions; other site 498214001289 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 498214001290 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 498214001291 ABC-ATPase subunit interface; other site 498214001292 dimer interface [polypeptide binding]; other site 498214001293 putative PBP binding regions; other site 498214001294 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 498214001295 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 498214001296 Walker A/P-loop; other site 498214001297 ATP binding site [chemical binding]; other site 498214001298 Q-loop/lid; other site 498214001299 ABC transporter signature motif; other site 498214001300 Walker B; other site 498214001301 D-loop; other site 498214001302 H-loop/switch region; other site 498214001303 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 498214001304 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 498214001305 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 498214001306 Walker A/P-loop; other site 498214001307 ATP binding site [chemical binding]; other site 498214001308 Q-loop/lid; other site 498214001309 ABC transporter signature motif; other site 498214001310 Walker B; other site 498214001311 D-loop; other site 498214001312 H-loop/switch region; other site 498214001313 xanthine permease; Region: pbuX; TIGR03173 498214001314 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498214001315 active site 498214001316 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214001317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214001318 active site 498214001319 phosphorylation site [posttranslational modification] 498214001320 intermolecular recognition site; other site 498214001321 dimerization interface [polypeptide binding]; other site 498214001322 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214001323 DNA binding site [nucleotide binding] 498214001324 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214001325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 498214001326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214001327 ATP binding site [chemical binding]; other site 498214001328 Mg2+ binding site [ion binding]; other site 498214001329 G-X-G motif; other site 498214001330 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 498214001331 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214001332 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498214001333 Walker A/P-loop; other site 498214001334 ATP binding site [chemical binding]; other site 498214001335 Q-loop/lid; other site 498214001336 ABC transporter signature motif; other site 498214001337 Walker B; other site 498214001338 D-loop; other site 498214001339 H-loop/switch region; other site 498214001340 FtsX-like permease family; Region: FtsX; pfam02687 498214001341 LrgA family; Region: LrgA; pfam03788 498214001342 LrgB-like family; Region: LrgB; pfam04172 498214001343 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214001344 Radical SAM superfamily; Region: Radical_SAM; pfam04055 498214001345 FeS/SAM binding site; other site 498214001346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 498214001347 hypothetical protein; Provisional; Region: PRK13663 498214001348 Accessory gene regulator B; Region: AgrB; pfam04647 498214001349 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 498214001350 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 498214001351 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 498214001352 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 498214001353 metal binding site [ion binding]; metal-binding site 498214001354 active site 498214001355 I-site; other site 498214001356 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 498214001357 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214001358 Zn2+ binding site [ion binding]; other site 498214001359 Mg2+ binding site [ion binding]; other site 498214001360 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 498214001361 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 498214001362 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 498214001363 PAS domain S-box; Region: sensory_box; TIGR00229 498214001364 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498214001365 putative active site [active] 498214001366 heme pocket [chemical binding]; other site 498214001367 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214001368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214001369 dimer interface [polypeptide binding]; other site 498214001370 phosphorylation site [posttranslational modification] 498214001371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214001372 ATP binding site [chemical binding]; other site 498214001373 Mg2+ binding site [ion binding]; other site 498214001374 G-X-G motif; other site 498214001375 Accessory gene regulator B; Region: AgrB; pfam04647 498214001376 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 498214001377 PAS domain S-box; Region: sensory_box; TIGR00229 498214001378 PAS domain; Region: PAS_8; pfam13188 498214001379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214001380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214001381 dimer interface [polypeptide binding]; other site 498214001382 phosphorylation site [posttranslational modification] 498214001383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214001384 ATP binding site [chemical binding]; other site 498214001385 Mg2+ binding site [ion binding]; other site 498214001386 G-X-G motif; other site 498214001387 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 498214001388 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 498214001389 Ligand Binding Site [chemical binding]; other site 498214001390 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214001391 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 498214001392 non-specific DNA binding site [nucleotide binding]; other site 498214001393 salt bridge; other site 498214001394 sequence-specific DNA binding site [nucleotide binding]; other site 498214001395 Cupin domain; Region: Cupin_2; pfam07883 498214001396 Amino acid permease; Region: AA_permease_2; pfam13520 498214001397 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 498214001398 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 498214001399 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 498214001400 active site 498214001401 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 498214001402 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 498214001403 putative catalytic cysteine [active] 498214001404 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 498214001405 putative active site [active] 498214001406 metal binding site [ion binding]; metal-binding site 498214001407 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 498214001408 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 498214001409 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 498214001410 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 498214001411 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 498214001412 active site 498214001413 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 498214001414 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 498214001415 NodB motif; other site 498214001416 active site 498214001417 catalytic site [active] 498214001418 Zn binding site [ion binding]; other site 498214001419 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214001420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214001421 active site 498214001422 phosphorylation site [posttranslational modification] 498214001423 intermolecular recognition site; other site 498214001424 dimerization interface [polypeptide binding]; other site 498214001425 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214001426 DNA binding site [nucleotide binding] 498214001427 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214001428 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214001429 dimerization interface [polypeptide binding]; other site 498214001430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214001431 dimer interface [polypeptide binding]; other site 498214001432 phosphorylation site [posttranslational modification] 498214001433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214001434 ATP binding site [chemical binding]; other site 498214001435 Mg2+ binding site [ion binding]; other site 498214001436 G-X-G motif; other site 498214001437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 498214001438 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 498214001439 Uncharacterized conserved protein [Function unknown]; Region: COG0398 498214001440 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 498214001441 CHASE4 domain; Region: CHASE4; pfam05228 498214001442 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214001443 dimerization interface [polypeptide binding]; other site 498214001444 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 498214001445 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 498214001446 metal binding site [ion binding]; metal-binding site 498214001447 active site 498214001448 I-site; other site 498214001449 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 498214001450 Putative amidase domain; Region: Amidase_6; pfam12671 498214001451 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 498214001452 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 498214001453 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 498214001454 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 498214001455 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 498214001456 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 498214001457 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 498214001458 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498214001459 catalytic residue [active] 498214001460 Predicted membrane protein [Function unknown]; Region: COG2855 498214001461 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 498214001462 active site 498214001463 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214001464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214001465 active site 498214001466 phosphorylation site [posttranslational modification] 498214001467 intermolecular recognition site; other site 498214001468 dimerization interface [polypeptide binding]; other site 498214001469 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214001470 DNA binding site [nucleotide binding] 498214001471 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214001472 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214001473 dimerization interface [polypeptide binding]; other site 498214001474 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214001475 dimer interface [polypeptide binding]; other site 498214001476 phosphorylation site [posttranslational modification] 498214001477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214001478 ATP binding site [chemical binding]; other site 498214001479 Mg2+ binding site [ion binding]; other site 498214001480 G-X-G motif; other site 498214001481 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 498214001482 Na binding site [ion binding]; other site 498214001483 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 498214001484 SLBB domain; Region: SLBB; pfam10531 498214001485 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498214001486 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 498214001487 FMN-binding domain; Region: FMN_bind; cl01081 498214001488 electron transport complex RsxE subunit; Provisional; Region: PRK12405 498214001489 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 498214001490 CheD chemotactic sensory transduction; Region: CheD; cl00810 498214001491 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 498214001492 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 498214001493 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 498214001494 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214001495 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214001496 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214001497 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 498214001498 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 498214001499 trimer interface [polypeptide binding]; other site 498214001500 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 498214001501 ApbE family; Region: ApbE; pfam02424 498214001502 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214001503 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214001504 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214001505 Bacterial Ig-like domain; Region: Big_5; pfam13205 498214001506 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214001507 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214001508 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214001509 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214001510 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214001511 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214001512 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 498214001513 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 498214001514 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 498214001515 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 498214001516 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214001517 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214001518 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214001519 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 498214001520 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 498214001521 Acyltransferase family; Region: Acyl_transf_3; pfam01757 498214001522 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 498214001523 Bacterial Ig-like domain; Region: Big_5; pfam13205 498214001524 PBP superfamily domain; Region: PBP_like_2; cl17296 498214001525 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 498214001526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214001527 dimer interface [polypeptide binding]; other site 498214001528 conserved gate region; other site 498214001529 putative PBP binding loops; other site 498214001530 ABC-ATPase subunit interface; other site 498214001531 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 498214001532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214001533 dimer interface [polypeptide binding]; other site 498214001534 conserved gate region; other site 498214001535 putative PBP binding loops; other site 498214001536 ABC-ATPase subunit interface; other site 498214001537 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 498214001538 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 498214001539 Walker A/P-loop; other site 498214001540 ATP binding site [chemical binding]; other site 498214001541 Q-loop/lid; other site 498214001542 ABC transporter signature motif; other site 498214001543 Walker B; other site 498214001544 D-loop; other site 498214001545 H-loop/switch region; other site 498214001546 Soluble P-type ATPase [General function prediction only]; Region: COG4087 498214001547 amino acid transporter; Region: 2A0306; TIGR00909 498214001548 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 498214001549 Protein of unknown function DUF45; Region: DUF45; pfam01863 498214001550 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 498214001551 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 498214001552 dimer interface [polypeptide binding]; other site 498214001553 ssDNA binding site [nucleotide binding]; other site 498214001554 tetramer (dimer of dimers) interface [polypeptide binding]; other site 498214001555 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 498214001556 metal binding site 2 [ion binding]; metal-binding site 498214001557 putative DNA binding helix; other site 498214001558 metal binding site 1 [ion binding]; metal-binding site 498214001559 dimer interface [polypeptide binding]; other site 498214001560 structural Zn2+ binding site [ion binding]; other site 498214001561 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 498214001562 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214001563 Zn2+ binding site [ion binding]; other site 498214001564 Mg2+ binding site [ion binding]; other site 498214001565 Rhomboid family; Region: Rhomboid; pfam01694 498214001566 Cache domain; Region: Cache_1; pfam02743 498214001567 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214001568 dimerization interface [polypeptide binding]; other site 498214001569 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498214001570 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214001571 dimer interface [polypeptide binding]; other site 498214001572 putative CheW interface [polypeptide binding]; other site 498214001573 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 498214001574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214001575 Walker A motif; other site 498214001576 ATP binding site [chemical binding]; other site 498214001577 Walker B motif; other site 498214001578 arginine finger; other site 498214001579 Peptidase family M41; Region: Peptidase_M41; pfam01434 498214001580 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 498214001581 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 498214001582 RNA/DNA hybrid binding site [nucleotide binding]; other site 498214001583 active site 498214001584 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 498214001585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214001586 non-specific DNA binding site [nucleotide binding]; other site 498214001587 salt bridge; other site 498214001588 sequence-specific DNA binding site [nucleotide binding]; other site 498214001589 Tetratricopeptide repeat; Region: TPR_12; pfam13424 498214001590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 498214001591 binding surface 498214001592 TPR motif; other site 498214001593 Tetratricopeptide repeat; Region: TPR_12; pfam13424 498214001594 Helix-turn-helix domain; Region: HTH_19; pfam12844 498214001595 DJ-1 family protein; Region: not_thiJ; TIGR01383 498214001596 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 498214001597 conserved cys residue [active] 498214001598 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 498214001599 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 498214001600 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 498214001601 Clp amino terminal domain; Region: Clp_N; pfam02861 498214001602 Clp amino terminal domain; Region: Clp_N; pfam02861 498214001603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214001604 Walker A motif; other site 498214001605 ATP binding site [chemical binding]; other site 498214001606 Walker B motif; other site 498214001607 arginine finger; other site 498214001608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214001609 Walker A motif; other site 498214001610 ATP binding site [chemical binding]; other site 498214001611 Walker B motif; other site 498214001612 arginine finger; other site 498214001613 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 498214001614 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 498214001615 catalytic triad [active] 498214001616 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 498214001617 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 498214001618 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 498214001619 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 498214001620 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 498214001621 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 498214001622 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 498214001623 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 498214001624 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 498214001625 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 498214001626 putative acyl-acceptor binding pocket; other site 498214001627 isopropylmalate/citramalate/homocitrate synthases; Region: LEU1_arch; TIGR02090 498214001628 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 498214001629 active site 498214001630 catalytic residues [active] 498214001631 metal binding site [ion binding]; metal-binding site 498214001632 aconitate hydratase; Validated; Region: PRK07229 498214001633 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 498214001634 substrate binding site [chemical binding]; other site 498214001635 ligand binding site [chemical binding]; other site 498214001636 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 498214001637 substrate binding site [chemical binding]; other site 498214001638 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 498214001639 tartrate dehydrogenase; Region: TTC; TIGR02089 498214001640 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 498214001641 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 498214001642 Walker A/P-loop; other site 498214001643 ATP binding site [chemical binding]; other site 498214001644 Q-loop/lid; other site 498214001645 ABC transporter signature motif; other site 498214001646 Walker B; other site 498214001647 D-loop; other site 498214001648 H-loop/switch region; other site 498214001649 Permease; Region: Permease; cl00510 498214001650 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 498214001651 Uncharacterized conserved protein [Function unknown]; Region: COG2155 498214001652 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 498214001653 tetramerization interface [polypeptide binding]; other site 498214001654 active site 498214001655 Pantoate-beta-alanine ligase; Region: PanC; cd00560 498214001656 pantoate--beta-alanine ligase; Region: panC; TIGR00018 498214001657 active site 498214001658 ATP-binding site [chemical binding]; other site 498214001659 pantoate-binding site; other site 498214001660 HXXH motif; other site 498214001661 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 498214001662 oligomerization interface [polypeptide binding]; other site 498214001663 active site 498214001664 metal binding site [ion binding]; metal-binding site 498214001665 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 498214001666 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 498214001667 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 498214001668 VanZ like family; Region: VanZ; pfam04892 498214001669 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498214001670 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498214001671 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498214001672 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 498214001673 Family description; Region: UvrD_C_2; pfam13538 498214001674 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 498214001675 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 498214001676 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214001677 dimer interface [polypeptide binding]; other site 498214001678 putative CheW interface [polypeptide binding]; other site 498214001679 peptidase T; Region: peptidase-T; TIGR01882 498214001680 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 498214001681 metal binding site [ion binding]; metal-binding site 498214001682 dimer interface [polypeptide binding]; other site 498214001683 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 498214001684 active site 498214001685 nucleophile elbow; other site 498214001686 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498214001687 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 498214001688 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 498214001689 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 498214001690 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214001691 non-specific DNA binding site [nucleotide binding]; other site 498214001692 salt bridge; other site 498214001693 sequence-specific DNA binding site [nucleotide binding]; other site 498214001694 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214001695 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214001696 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214001697 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 498214001698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214001699 dimer interface [polypeptide binding]; other site 498214001700 conserved gate region; other site 498214001701 putative PBP binding loops; other site 498214001702 ABC-ATPase subunit interface; other site 498214001703 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 498214001704 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 498214001705 substrate binding pocket [chemical binding]; other site 498214001706 membrane-bound complex binding site; other site 498214001707 hinge residues; other site 498214001708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214001709 S-adenosylmethionine binding site [chemical binding]; other site 498214001710 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 498214001711 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 498214001712 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 498214001713 thiamine phosphate binding site [chemical binding]; other site 498214001714 active site 498214001715 pyrophosphate binding site [ion binding]; other site 498214001716 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 498214001717 substrate binding site [chemical binding]; other site 498214001718 multimerization interface [polypeptide binding]; other site 498214001719 ATP binding site [chemical binding]; other site 498214001720 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 498214001721 dimer interface [polypeptide binding]; other site 498214001722 substrate binding site [chemical binding]; other site 498214001723 ATP binding site [chemical binding]; other site 498214001724 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 498214001725 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 498214001726 ATP-grasp domain; Region: ATP-grasp_4; cl17255 498214001727 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 498214001728 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 498214001729 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 498214001730 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 498214001731 TM-ABC transporter signature motif; other site 498214001732 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 498214001733 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 498214001734 TM-ABC transporter signature motif; other site 498214001735 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 498214001736 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 498214001737 Walker A/P-loop; other site 498214001738 ATP binding site [chemical binding]; other site 498214001739 Q-loop/lid; other site 498214001740 ABC transporter signature motif; other site 498214001741 Walker B; other site 498214001742 D-loop; other site 498214001743 H-loop/switch region; other site 498214001744 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 498214001745 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 498214001746 Walker A/P-loop; other site 498214001747 ATP binding site [chemical binding]; other site 498214001748 Q-loop/lid; other site 498214001749 ABC transporter signature motif; other site 498214001750 Walker B; other site 498214001751 D-loop; other site 498214001752 H-loop/switch region; other site 498214001753 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 498214001754 Uncharacterized conserved protein [Function unknown]; Region: COG2966 498214001755 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 498214001756 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 498214001757 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 498214001758 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214001759 DNA-binding site [nucleotide binding]; DNA binding site 498214001760 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498214001761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214001762 homodimer interface [polypeptide binding]; other site 498214001763 catalytic residue [active] 498214001764 LemA family; Region: LemA; cl00742 498214001765 Repair protein; Region: Repair_PSII; pfam04536 498214001766 Repair protein; Region: Repair_PSII; pfam04536 498214001767 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 498214001768 nudix motif; other site 498214001769 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 498214001770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 498214001771 Methyltransferase domain; Region: Methyltransf_31; pfam13847 498214001772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214001773 S-adenosylmethionine binding site [chemical binding]; other site 498214001774 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214001775 salt bridge; other site 498214001776 non-specific DNA binding site [nucleotide binding]; other site 498214001777 sequence-specific DNA binding site [nucleotide binding]; other site 498214001778 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 498214001779 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 498214001780 active site 498214001781 metal binding site [ion binding]; metal-binding site 498214001782 DNA binding site [nucleotide binding] 498214001783 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 498214001784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214001785 AAA domain; Region: AAA_23; pfam13476 498214001786 Walker A/P-loop; other site 498214001787 ATP binding site [chemical binding]; other site 498214001788 Q-loop/lid; other site 498214001789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214001790 ABC transporter signature motif; other site 498214001791 Walker B; other site 498214001792 D-loop; other site 498214001793 H-loop/switch region; other site 498214001794 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 498214001795 ADP-ribose binding site [chemical binding]; other site 498214001796 dimer interface [polypeptide binding]; other site 498214001797 active site 498214001798 nudix motif; other site 498214001799 metal binding site [ion binding]; metal-binding site 498214001800 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 498214001801 putative active site [active] 498214001802 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 498214001803 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 498214001804 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 498214001805 putative active site [active] 498214001806 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 498214001807 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 498214001808 Walker A/P-loop; other site 498214001809 ATP binding site [chemical binding]; other site 498214001810 Q-loop/lid; other site 498214001811 ABC transporter signature motif; other site 498214001812 Walker B; other site 498214001813 D-loop; other site 498214001814 H-loop/switch region; other site 498214001815 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 498214001816 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 498214001817 HlyD family secretion protein; Region: HlyD_3; pfam13437 498214001818 Uncharacterized conserved protein [Function unknown]; Region: COG1284 498214001819 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 498214001820 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 498214001821 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 498214001822 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 498214001823 dimerization interface [polypeptide binding]; other site 498214001824 putative DNA binding site [nucleotide binding]; other site 498214001825 putative Zn2+ binding site [ion binding]; other site 498214001826 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 498214001827 Heavy-metal-associated domain; Region: HMA; pfam00403 498214001828 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 498214001829 Soluble P-type ATPase [General function prediction only]; Region: COG4087 498214001830 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 498214001831 NlpC/P60 family; Region: NLPC_P60; pfam00877 498214001832 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498214001833 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 498214001834 Walker A/P-loop; other site 498214001835 ATP binding site [chemical binding]; other site 498214001836 Q-loop/lid; other site 498214001837 ABC transporter signature motif; other site 498214001838 Walker B; other site 498214001839 D-loop; other site 498214001840 H-loop/switch region; other site 498214001841 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 498214001842 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 498214001843 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 498214001844 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 498214001845 putative active site [active] 498214001846 PhoH-like protein; Region: PhoH; pfam02562 498214001847 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 498214001848 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 498214001849 NADPH bind site [chemical binding]; other site 498214001850 putative FMN binding site [chemical binding]; other site 498214001851 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 498214001852 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 498214001853 YcaO-like family; Region: YcaO; pfam02624 498214001854 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 498214001855 CAAX protease self-immunity; Region: Abi; pfam02517 498214001856 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 498214001857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214001858 Walker A/P-loop; other site 498214001859 ATP binding site [chemical binding]; other site 498214001860 Q-loop/lid; other site 498214001861 ABC transporter signature motif; other site 498214001862 Walker B; other site 498214001863 D-loop; other site 498214001864 H-loop/switch region; other site 498214001865 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 498214001866 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 498214001867 ABC-2 type transporter; Region: ABC2_membrane; cl17235 498214001868 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 498214001869 ABC-2 type transporter; Region: ABC2_membrane; cl17235 498214001870 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 498214001871 Peptidase family M50; Region: Peptidase_M50; pfam02163 498214001872 active site 498214001873 putative substrate binding region [chemical binding]; other site 498214001874 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 498214001875 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 498214001876 transmembrane helices; other site 498214001877 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 498214001878 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 498214001879 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 498214001880 dimer interface [polypeptide binding]; other site 498214001881 catalytic triad [active] 498214001882 peroxidatic and resolving cysteines [active] 498214001883 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 498214001884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 498214001885 NAD(P) binding site [chemical binding]; other site 498214001886 active site 498214001887 Response regulator receiver domain; Region: Response_reg; pfam00072 498214001888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214001889 active site 498214001890 phosphorylation site [posttranslational modification] 498214001891 intermolecular recognition site; other site 498214001892 dimerization interface [polypeptide binding]; other site 498214001893 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 498214001894 CHAP domain; Region: CHAP; pfam05257 498214001895 Bacterial SH3 domain; Region: SH3_3; pfam08239 498214001896 Bacterial SH3 domain; Region: SH3_3; pfam08239 498214001897 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 498214001898 Bacterial SH3 domain; Region: SH3_3; pfam08239 498214001899 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 498214001900 NlpC/P60 family; Region: NLPC_P60; pfam00877 498214001901 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 498214001902 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 498214001903 PAS fold; Region: PAS_4; pfam08448 498214001904 Response regulator receiver domain; Region: Response_reg; pfam00072 498214001905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214001906 active site 498214001907 phosphorylation site [posttranslational modification] 498214001908 intermolecular recognition site; other site 498214001909 dimerization interface [polypeptide binding]; other site 498214001910 Hpt domain; Region: Hpt; pfam01627 498214001911 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 498214001912 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214001913 Zn2+ binding site [ion binding]; other site 498214001914 Mg2+ binding site [ion binding]; other site 498214001915 Cache domain; Region: Cache_1; pfam02743 498214001916 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 498214001917 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214001918 dimerization interface [polypeptide binding]; other site 498214001919 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214001920 dimer interface [polypeptide binding]; other site 498214001921 putative CheW interface [polypeptide binding]; other site 498214001922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214001923 active site 498214001924 phosphorylation site [posttranslational modification] 498214001925 intermolecular recognition site; other site 498214001926 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 498214001927 seryl-tRNA synthetase; Provisional; Region: PRK05431 498214001928 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 498214001929 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 498214001930 motif 1; other site 498214001931 dimer interface [polypeptide binding]; other site 498214001932 active site 498214001933 motif 2; other site 498214001934 motif 3; other site 498214001935 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 498214001936 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 498214001937 DEAD_2; Region: DEAD_2; pfam06733 498214001938 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 498214001939 Predicted transcriptional regulators [Transcription]; Region: COG1725 498214001940 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214001941 DNA-binding site [nucleotide binding]; DNA binding site 498214001942 TrkA-C domain; Region: TrkA_C; pfam02080 498214001943 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 498214001944 putative active site [active] 498214001945 putative ligand binding site [chemical binding]; other site 498214001946 putative NAD(P) binding site [chemical binding]; other site 498214001947 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 498214001948 Hemerythrin; Region: Hemerythrin; cd12107 498214001949 Fe binding site [ion binding]; other site 498214001950 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 498214001951 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 498214001952 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 498214001953 Amino acid permease; Region: AA_permease_2; pfam13520 498214001954 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 498214001955 AsnC family; Region: AsnC_trans_reg; pfam01037 498214001956 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 498214001957 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 498214001958 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 498214001959 Spore germination protein; Region: Spore_permease; cl17796 498214001960 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 498214001961 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 498214001962 trimer interface [polypeptide binding]; other site 498214001963 putative metal binding site [ion binding]; other site 498214001964 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 498214001965 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 498214001966 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 498214001967 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 498214001968 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 498214001969 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 498214001970 Soluble P-type ATPase [General function prediction only]; Region: COG4087 498214001971 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 498214001972 Chromate transporter; Region: Chromate_transp; pfam02417 498214001973 Chromate transporter; Region: Chromate_transp; pfam02417 498214001974 PemK-like protein; Region: PemK; pfam02452 498214001975 Protein of unknown function (DUF327); Region: DUF327; pfam03885 498214001976 NAD synthetase; Reviewed; Region: nadE; PRK02628 498214001977 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 498214001978 multimer interface [polypeptide binding]; other site 498214001979 active site 498214001980 catalytic triad [active] 498214001981 protein interface 1 [polypeptide binding]; other site 498214001982 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 498214001983 homodimer interface [polypeptide binding]; other site 498214001984 NAD binding pocket [chemical binding]; other site 498214001985 ATP binding pocket [chemical binding]; other site 498214001986 Mg binding site [ion binding]; other site 498214001987 active-site loop [active] 498214001988 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 498214001989 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 498214001990 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 498214001991 CAAX protease self-immunity; Region: Abi; pfam02517 498214001992 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 498214001993 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 498214001994 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 498214001995 active site 498214001996 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 498214001997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214001998 Coenzyme A binding pocket [chemical binding]; other site 498214001999 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 498214002000 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214002001 Coenzyme A binding pocket [chemical binding]; other site 498214002002 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 498214002003 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 498214002004 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 498214002005 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 498214002006 Carbon starvation protein CstA; Region: CstA; pfam02554 498214002007 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 498214002008 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 498214002009 Cache domain; Region: Cache_1; pfam02743 498214002010 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498214002011 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214002012 dimer interface [polypeptide binding]; other site 498214002013 putative CheW interface [polypeptide binding]; other site 498214002014 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214002015 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498214002016 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 498214002017 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498214002018 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 498214002019 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 498214002020 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 498214002021 SEC-C motif; Region: SEC-C; pfam02810 498214002022 Predicted transcriptional regulators [Transcription]; Region: COG1725 498214002023 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214002024 DNA-binding site [nucleotide binding]; DNA binding site 498214002025 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 498214002026 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 498214002027 Walker A/P-loop; other site 498214002028 ATP binding site [chemical binding]; other site 498214002029 Q-loop/lid; other site 498214002030 ABC transporter signature motif; other site 498214002031 Walker B; other site 498214002032 D-loop; other site 498214002033 H-loop/switch region; other site 498214002034 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 498214002035 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 498214002036 Walker A/P-loop; other site 498214002037 ATP binding site [chemical binding]; other site 498214002038 Q-loop/lid; other site 498214002039 ABC transporter signature motif; other site 498214002040 Walker B; other site 498214002041 D-loop; other site 498214002042 H-loop/switch region; other site 498214002043 TOBE domain; Region: TOBE_2; pfam08402 498214002044 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 498214002045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214002046 dimer interface [polypeptide binding]; other site 498214002047 conserved gate region; other site 498214002048 putative PBP binding loops; other site 498214002049 ABC-ATPase subunit interface; other site 498214002050 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 498214002051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214002052 dimer interface [polypeptide binding]; other site 498214002053 conserved gate region; other site 498214002054 putative PBP binding loops; other site 498214002055 ABC-ATPase subunit interface; other site 498214002056 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 498214002057 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 498214002058 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 498214002059 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214002060 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214002061 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 498214002062 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 498214002063 CAAX protease self-immunity; Region: Abi; pfam02517 498214002064 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 498214002065 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 498214002066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214002067 non-specific DNA binding site [nucleotide binding]; other site 498214002068 salt bridge; other site 498214002069 sequence-specific DNA binding site [nucleotide binding]; other site 498214002070 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 498214002071 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 498214002072 Catalytic site [active] 498214002073 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 498214002074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214002075 active site 498214002076 phosphorylation site [posttranslational modification] 498214002077 intermolecular recognition site; other site 498214002078 dimerization interface [polypeptide binding]; other site 498214002079 LytTr DNA-binding domain; Region: LytTR; smart00850 498214002080 Cys-rich peptide, Clo7bot family; Region: Clo7Bot_mod_Cys; TIGR04333 498214002081 Cys-rich peptide, Clo7bot family; Region: Clo7Bot_mod_Cys; TIGR04333 498214002082 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 498214002083 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214002084 FeS/SAM binding site; other site 498214002085 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 498214002086 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 498214002087 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214002088 Coenzyme A binding pocket [chemical binding]; other site 498214002089 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 498214002090 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 498214002091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214002092 Walker A/P-loop; other site 498214002093 ATP binding site [chemical binding]; other site 498214002094 Q-loop/lid; other site 498214002095 ABC transporter signature motif; other site 498214002096 Walker B; other site 498214002097 D-loop; other site 498214002098 H-loop/switch region; other site 498214002099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 498214002100 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 498214002101 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 498214002102 FtsX-like permease family; Region: FtsX; pfam02687 498214002103 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 498214002104 FtsX-like permease family; Region: FtsX; pfam02687 498214002105 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498214002106 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214002107 Walker A/P-loop; other site 498214002108 ATP binding site [chemical binding]; other site 498214002109 Q-loop/lid; other site 498214002110 ABC transporter signature motif; other site 498214002111 Walker B; other site 498214002112 D-loop; other site 498214002113 H-loop/switch region; other site 498214002114 EDD domain protein, DegV family; Region: DegV; TIGR00762 498214002115 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 498214002116 hypothetical protein; Provisional; Region: PRK04164 498214002117 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 498214002118 Sulfatase; Region: Sulfatase; pfam00884 498214002119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214002120 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 498214002121 Walker A motif; other site 498214002122 ATP binding site [chemical binding]; other site 498214002123 Walker B motif; other site 498214002124 arginine finger; other site 498214002125 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 498214002126 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 498214002127 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 498214002128 Nucleoside recognition; Region: Gate; pfam07670 498214002129 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 498214002130 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 498214002131 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 498214002132 putative dimer interface [polypeptide binding]; other site 498214002133 putative anticodon binding site; other site 498214002134 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 498214002135 homodimer interface [polypeptide binding]; other site 498214002136 motif 1; other site 498214002137 motif 2; other site 498214002138 active site 498214002139 motif 3; other site 498214002140 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 498214002141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498214002142 putative substrate translocation pore; other site 498214002143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498214002144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498214002145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498214002146 Predicted transcriptional regulators [Transcription]; Region: COG1695 498214002147 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 498214002148 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214002149 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 498214002150 LytTr DNA-binding domain; Region: LytTR; smart00850 498214002151 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214002152 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214002153 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 498214002154 Protein of unknown function (DUF3595); Region: DUF3595; pfam12166 498214002155 CAAX protease self-immunity; Region: Abi; pfam02517 498214002156 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 498214002157 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214002158 non-specific DNA binding site [nucleotide binding]; other site 498214002159 salt bridge; other site 498214002160 sequence-specific DNA binding site [nucleotide binding]; other site 498214002161 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 498214002162 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 498214002163 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214002164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214002165 active site 498214002166 phosphorylation site [posttranslational modification] 498214002167 intermolecular recognition site; other site 498214002168 dimerization interface [polypeptide binding]; other site 498214002169 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214002170 DNA binding site [nucleotide binding] 498214002171 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214002172 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214002173 dimerization interface [polypeptide binding]; other site 498214002174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214002175 dimer interface [polypeptide binding]; other site 498214002176 phosphorylation site [posttranslational modification] 498214002177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214002178 ATP binding site [chemical binding]; other site 498214002179 Mg2+ binding site [ion binding]; other site 498214002180 G-X-G motif; other site 498214002181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214002182 Coenzyme A binding pocket [chemical binding]; other site 498214002183 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 498214002184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214002185 Coenzyme A binding pocket [chemical binding]; other site 498214002186 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 498214002187 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 498214002188 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214002189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214002190 active site 498214002191 phosphorylation site [posttranslational modification] 498214002192 intermolecular recognition site; other site 498214002193 dimerization interface [polypeptide binding]; other site 498214002194 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214002195 DNA binding site [nucleotide binding] 498214002196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214002197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214002198 dimer interface [polypeptide binding]; other site 498214002199 phosphorylation site [posttranslational modification] 498214002200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214002201 ATP binding site [chemical binding]; other site 498214002202 Mg2+ binding site [ion binding]; other site 498214002203 G-X-G motif; other site 498214002204 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 498214002205 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 498214002206 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 498214002207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214002208 active site 498214002209 phosphorylation site [posttranslational modification] 498214002210 intermolecular recognition site; other site 498214002211 dimerization interface [polypeptide binding]; other site 498214002212 YcbB domain; Region: YcbB; pfam08664 498214002213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214002214 ATP binding site [chemical binding]; other site 498214002215 Mg2+ binding site [ion binding]; other site 498214002216 G-X-G motif; other site 498214002217 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 498214002218 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 498214002219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214002220 S-adenosylmethionine binding site [chemical binding]; other site 498214002221 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 498214002222 dimerization interface [polypeptide binding]; other site 498214002223 putative Zn2+ binding site [ion binding]; other site 498214002224 putative DNA binding site [nucleotide binding]; other site 498214002225 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 498214002226 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 498214002227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214002228 Walker A/P-loop; other site 498214002229 ATP binding site [chemical binding]; other site 498214002230 Q-loop/lid; other site 498214002231 ABC transporter signature motif; other site 498214002232 Walker B; other site 498214002233 D-loop; other site 498214002234 H-loop/switch region; other site 498214002235 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 498214002236 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 498214002237 Chloramphenicol acetyltransferase; Region: CAT; smart01059 498214002238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498214002239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498214002240 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 498214002241 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214002242 Coenzyme A binding pocket [chemical binding]; other site 498214002243 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 498214002244 dimer interface [polypeptide binding]; other site 498214002245 putative tRNA-binding site [nucleotide binding]; other site 498214002246 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 498214002247 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214002248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214002249 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214002250 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 498214002251 non-specific DNA binding site [nucleotide binding]; other site 498214002252 salt bridge; other site 498214002253 sequence-specific DNA binding site [nucleotide binding]; other site 498214002254 Cupin domain; Region: Cupin_2; pfam07883 498214002255 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 498214002256 Zn2+ binding site [ion binding]; other site 498214002257 Mg2+ binding site [ion binding]; other site 498214002258 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 498214002259 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 498214002260 active site 498214002261 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 498214002262 MutS domain III; Region: MutS_III; pfam05192 498214002263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214002264 Walker A/P-loop; other site 498214002265 ATP binding site [chemical binding]; other site 498214002266 Q-loop/lid; other site 498214002267 ABC transporter signature motif; other site 498214002268 Walker B; other site 498214002269 D-loop; other site 498214002270 H-loop/switch region; other site 498214002271 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 498214002272 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 498214002273 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 498214002274 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 498214002275 Protein of unknown function (DUF454); Region: DUF454; cl01063 498214002276 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 498214002277 5,10-methenyltetrahydromethanopterin hydrogenase cofactor biosynthesis protein HmdC; Region: monoFe_hyd_HmdC; TIGR03958 498214002278 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 498214002279 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214002280 DNA-binding site [nucleotide binding]; DNA binding site 498214002281 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498214002282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214002283 homodimer interface [polypeptide binding]; other site 498214002284 catalytic residue [active] 498214002285 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 498214002286 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 498214002287 ATP binding site [chemical binding]; other site 498214002288 Mg++ binding site [ion binding]; other site 498214002289 motif III; other site 498214002290 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498214002291 nucleotide binding region [chemical binding]; other site 498214002292 ATP-binding site [chemical binding]; other site 498214002293 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 498214002294 diiron binding motif [ion binding]; other site 498214002295 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 498214002296 MarR family; Region: MarR_2; pfam12802 498214002297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498214002298 Major Facilitator Superfamily; Region: MFS_1; pfam07690 498214002299 putative substrate translocation pore; other site 498214002300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498214002301 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 498214002302 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 498214002303 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 498214002304 Walker A/P-loop; other site 498214002305 ATP binding site [chemical binding]; other site 498214002306 Q-loop/lid; other site 498214002307 ABC transporter signature motif; other site 498214002308 Walker B; other site 498214002309 D-loop; other site 498214002310 H-loop/switch region; other site 498214002311 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 498214002312 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 498214002313 Walker A/P-loop; other site 498214002314 ATP binding site [chemical binding]; other site 498214002315 Q-loop/lid; other site 498214002316 ABC transporter signature motif; other site 498214002317 Walker B; other site 498214002318 D-loop; other site 498214002319 H-loop/switch region; other site 498214002320 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 498214002321 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 498214002322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214002323 dimer interface [polypeptide binding]; other site 498214002324 conserved gate region; other site 498214002325 putative PBP binding loops; other site 498214002326 ABC-ATPase subunit interface; other site 498214002327 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 498214002328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214002329 dimer interface [polypeptide binding]; other site 498214002330 conserved gate region; other site 498214002331 putative PBP binding loops; other site 498214002332 ABC-ATPase subunit interface; other site 498214002333 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 498214002334 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 498214002335 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 498214002336 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 498214002337 Walker A/P-loop; other site 498214002338 ATP binding site [chemical binding]; other site 498214002339 Q-loop/lid; other site 498214002340 ABC transporter signature motif; other site 498214002341 Walker B; other site 498214002342 D-loop; other site 498214002343 H-loop/switch region; other site 498214002344 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 498214002345 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 498214002346 ABC-2 type transporter; Region: ABC2_membrane; cl17235 498214002347 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 498214002348 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 498214002349 Transcriptional regulator [Transcription]; Region: LysR; COG0583 498214002350 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 498214002351 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 498214002352 dimerization interface [polypeptide binding]; other site 498214002353 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 498214002354 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 498214002355 putative active site [active] 498214002356 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 498214002357 PLD-like domain; Region: PLDc_2; pfam13091 498214002358 putative homodimer interface [polypeptide binding]; other site 498214002359 putative active site [active] 498214002360 catalytic site [active] 498214002361 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 498214002362 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498214002363 ATP binding site [chemical binding]; other site 498214002364 putative Mg++ binding site [ion binding]; other site 498214002365 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498214002366 nucleotide binding region [chemical binding]; other site 498214002367 ATP-binding site [chemical binding]; other site 498214002368 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 498214002369 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 498214002370 active site 498214002371 8-oxo-dGMP binding site [chemical binding]; other site 498214002372 nudix motif; other site 498214002373 metal binding site [ion binding]; metal-binding site 498214002374 transcriptional antiterminator BglG; Provisional; Region: PRK09772 498214002375 CAT RNA binding domain; Region: CAT_RBD; smart01061 498214002376 PRD domain; Region: PRD; pfam00874 498214002377 PRD domain; Region: PRD; pfam00874 498214002378 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 498214002379 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 498214002380 active site turn [active] 498214002381 phosphorylation site [posttranslational modification] 498214002382 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 498214002383 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 498214002384 HPr interaction site; other site 498214002385 glycerol kinase (GK) interaction site [polypeptide binding]; other site 498214002386 active site 498214002387 phosphorylation site [posttranslational modification] 498214002388 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 498214002389 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 498214002390 active site 498214002391 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 498214002392 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 498214002393 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 498214002394 ligand binding site [chemical binding]; other site 498214002395 flexible hinge region; other site 498214002396 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 498214002397 putative switch regulator; other site 498214002398 non-specific DNA interactions [nucleotide binding]; other site 498214002399 DNA binding site [nucleotide binding] 498214002400 sequence specific DNA binding site [nucleotide binding]; other site 498214002401 putative cAMP binding site [chemical binding]; other site 498214002402 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 498214002403 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498214002404 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 498214002405 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 498214002406 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 498214002407 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 498214002408 Family of unknown function (DUF438); Region: DUF438; pfam04282 498214002409 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 498214002410 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 498214002411 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 498214002412 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 498214002413 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 498214002414 intersubunit interface [polypeptide binding]; other site 498214002415 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 498214002416 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 498214002417 ABC-ATPase subunit interface; other site 498214002418 dimer interface [polypeptide binding]; other site 498214002419 putative PBP binding regions; other site 498214002420 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 498214002421 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 498214002422 Walker A/P-loop; other site 498214002423 ATP binding site [chemical binding]; other site 498214002424 Q-loop/lid; other site 498214002425 ABC transporter signature motif; other site 498214002426 Walker B; other site 498214002427 D-loop; other site 498214002428 H-loop/switch region; other site 498214002429 CGGC domain; Region: CGGC; pfam08821 498214002430 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498214002431 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 498214002432 TM-ABC transporter signature motif; other site 498214002433 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 498214002434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214002435 Walker A/P-loop; other site 498214002436 ATP binding site [chemical binding]; other site 498214002437 Q-loop/lid; other site 498214002438 ABC transporter signature motif; other site 498214002439 Walker B; other site 498214002440 D-loop; other site 498214002441 H-loop/switch region; other site 498214002442 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 498214002443 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 498214002444 zinc binding site [ion binding]; other site 498214002445 putative ligand binding site [chemical binding]; other site 498214002446 Penicillinase repressor; Region: Pencillinase_R; pfam03965 498214002447 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 498214002448 RNA polymerase factor sigma-70; Validated; Region: PRK06811 498214002449 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498214002450 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 498214002451 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 498214002452 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 498214002453 FMN binding site [chemical binding]; other site 498214002454 active site 498214002455 catalytic residues [active] 498214002456 substrate binding site [chemical binding]; other site 498214002457 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 498214002458 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 498214002459 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214002460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214002461 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 498214002462 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 498214002463 intersubunit interface [polypeptide binding]; other site 498214002464 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 498214002465 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 498214002466 ABC-ATPase subunit interface; other site 498214002467 dimer interface [polypeptide binding]; other site 498214002468 putative PBP binding regions; other site 498214002469 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 498214002470 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 498214002471 ABC-ATPase subunit interface; other site 498214002472 dimer interface [polypeptide binding]; other site 498214002473 putative PBP binding regions; other site 498214002474 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 498214002475 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 498214002476 Walker A/P-loop; other site 498214002477 ATP binding site [chemical binding]; other site 498214002478 Q-loop/lid; other site 498214002479 ABC transporter signature motif; other site 498214002480 Walker B; other site 498214002481 D-loop; other site 498214002482 H-loop/switch region; other site 498214002483 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498214002484 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 498214002485 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 498214002486 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 498214002487 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 498214002488 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316 498214002489 Cache domain; Region: Cache_1; pfam02743 498214002490 HAMP domain; Region: HAMP; pfam00672 498214002491 dimerization interface [polypeptide binding]; other site 498214002492 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498214002493 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214002494 dimer interface [polypeptide binding]; other site 498214002495 putative CheW interface [polypeptide binding]; other site 498214002496 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 498214002497 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 498214002498 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 498214002499 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 498214002500 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 498214002501 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 498214002502 glycine cleavage system protein H; Provisional; Region: PRK13380 498214002503 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 498214002504 lipoyl attachment site [posttranslational modification]; other site 498214002505 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 498214002506 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 498214002507 tetramer interface [polypeptide binding]; other site 498214002508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214002509 catalytic residue [active] 498214002510 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 498214002511 tetramer interface [polypeptide binding]; other site 498214002512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214002513 catalytic residue [active] 498214002514 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 498214002515 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 498214002516 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 498214002517 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 498214002518 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 498214002519 Homeodomain-like domain; Region: HTH_23; cl17451 498214002520 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 498214002521 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 498214002522 Helix-turn-helix domain; Region: HTH_17; pfam12728 498214002523 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214002524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214002525 active site 498214002526 phosphorylation site [posttranslational modification] 498214002527 intermolecular recognition site; other site 498214002528 dimerization interface [polypeptide binding]; other site 498214002529 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214002530 DNA binding site [nucleotide binding] 498214002531 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214002532 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214002533 dimer interface [polypeptide binding]; other site 498214002534 phosphorylation site [posttranslational modification] 498214002535 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214002536 ATP binding site [chemical binding]; other site 498214002537 Mg2+ binding site [ion binding]; other site 498214002538 G-X-G motif; other site 498214002539 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214002540 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498214002541 Walker A/P-loop; other site 498214002542 ATP binding site [chemical binding]; other site 498214002543 Q-loop/lid; other site 498214002544 ABC transporter signature motif; other site 498214002545 Walker B; other site 498214002546 D-loop; other site 498214002547 H-loop/switch region; other site 498214002548 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 498214002549 FtsX-like permease family; Region: FtsX; pfam02687 498214002550 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 498214002551 MarR family; Region: MarR; pfam01047 498214002552 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 498214002553 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 498214002554 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 498214002555 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214002556 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 498214002557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 498214002558 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 498214002559 DNA binding residues [nucleotide binding] 498214002560 AAA ATPase domain; Region: AAA_15; pfam13175 498214002561 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 498214002562 active site 498214002563 metal binding site [ion binding]; metal-binding site 498214002564 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 498214002565 active site 498214002566 metal binding site [ion binding]; metal-binding site 498214002567 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137 498214002568 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 498214002569 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 498214002570 DNA binding residues [nucleotide binding] 498214002571 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 498214002572 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 498214002573 DNA binding residues [nucleotide binding] 498214002574 dimer interface [polypeptide binding]; other site 498214002575 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 498214002576 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 498214002577 Walker A/P-loop; other site 498214002578 ATP binding site [chemical binding]; other site 498214002579 Q-loop/lid; other site 498214002580 ABC transporter signature motif; other site 498214002581 Walker B; other site 498214002582 D-loop; other site 498214002583 H-loop/switch region; other site 498214002584 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 498214002585 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 498214002586 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 498214002587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214002588 Coenzyme A binding pocket [chemical binding]; other site 498214002589 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214002590 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214002591 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 498214002592 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 498214002593 active site 498214002594 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 498214002595 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498214002596 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214002597 dimer interface [polypeptide binding]; other site 498214002598 putative CheW interface [polypeptide binding]; other site 498214002599 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 498214002600 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498214002601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214002602 Walker A/P-loop; other site 498214002603 ATP binding site [chemical binding]; other site 498214002604 Q-loop/lid; other site 498214002605 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498214002606 ABC transporter signature motif; other site 498214002607 ABC transporter; Region: ABC_tran_2; pfam12848 498214002608 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498214002609 WYL domain; Region: WYL; cl14852 498214002610 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 498214002611 conserved cys residue [active] 498214002612 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 498214002613 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 498214002614 dimer interface [polypeptide binding]; other site 498214002615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214002616 catalytic residue [active] 498214002617 S-ribosylhomocysteinase; Provisional; Region: PRK02260 498214002618 cystathionine beta-lyase; Provisional; Region: PRK07671 498214002619 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 498214002620 homodimer interface [polypeptide binding]; other site 498214002621 substrate-cofactor binding pocket; other site 498214002622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214002623 catalytic residue [active] 498214002624 Methyltransferase domain; Region: Methyltransf_31; pfam13847 498214002625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214002626 S-adenosylmethionine binding site [chemical binding]; other site 498214002627 Glyco_18 domain; Region: Glyco_18; smart00636 498214002628 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 498214002629 active site 498214002630 Chitinase C; Region: ChiC; pfam06483 498214002631 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 498214002632 metal-binding site [ion binding] 498214002633 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 498214002634 Domain of unknown function (DUF955); Region: DUF955; pfam06114 498214002635 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 498214002636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214002637 non-specific DNA binding site [nucleotide binding]; other site 498214002638 salt bridge; other site 498214002639 sequence-specific DNA binding site [nucleotide binding]; other site 498214002640 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214002641 non-specific DNA binding site [nucleotide binding]; other site 498214002642 salt bridge; other site 498214002643 sequence-specific DNA binding site [nucleotide binding]; other site 498214002644 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 498214002645 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 498214002646 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498214002647 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 498214002648 DNA binding residues [nucleotide binding] 498214002649 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 498214002650 active site 498214002651 metal binding site [ion binding]; metal-binding site 498214002652 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 498214002653 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 498214002654 Predicted transcriptional regulators [Transcription]; Region: COG1733 498214002655 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 498214002656 MarR family; Region: MarR_2; pfam12802 498214002657 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 498214002658 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 498214002659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214002660 Walker A/P-loop; other site 498214002661 ATP binding site [chemical binding]; other site 498214002662 Q-loop/lid; other site 498214002663 ABC transporter signature motif; other site 498214002664 Walker B; other site 498214002665 D-loop; other site 498214002666 H-loop/switch region; other site 498214002667 Low molecular weight phosphatase family; Region: LMWPc; cl00105 498214002668 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 498214002669 dimerization interface [polypeptide binding]; other site 498214002670 putative DNA binding site [nucleotide binding]; other site 498214002671 putative Zn2+ binding site [ion binding]; other site 498214002672 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 498214002673 catalytic core [active] 498214002674 Short C-terminal domain; Region: SHOCT; pfam09851 498214002675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498214002676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498214002677 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 498214002678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214002679 Walker A/P-loop; other site 498214002680 ATP binding site [chemical binding]; other site 498214002681 Q-loop/lid; other site 498214002682 ABC transporter signature motif; other site 498214002683 Walker B; other site 498214002684 D-loop; other site 498214002685 H-loop/switch region; other site 498214002686 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 498214002687 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 498214002688 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 498214002689 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 498214002690 dimerization interface [polypeptide binding]; other site 498214002691 active site 498214002692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214002693 S-adenosylmethionine binding site [chemical binding]; other site 498214002694 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 498214002695 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 498214002696 dimer interface [polypeptide binding]; other site 498214002697 substrate binding site [chemical binding]; other site 498214002698 ATP binding site [chemical binding]; other site 498214002699 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 498214002700 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 498214002701 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 498214002702 Walker A/P-loop; other site 498214002703 ATP binding site [chemical binding]; other site 498214002704 Q-loop/lid; other site 498214002705 ABC transporter signature motif; other site 498214002706 Walker B; other site 498214002707 D-loop; other site 498214002708 H-loop/switch region; other site 498214002709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 498214002710 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214002711 G-X-G motif; other site 498214002712 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 498214002713 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214002714 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498214002715 Walker A/P-loop; other site 498214002716 ATP binding site [chemical binding]; other site 498214002717 Q-loop/lid; other site 498214002718 ABC transporter signature motif; other site 498214002719 Walker B; other site 498214002720 D-loop; other site 498214002721 H-loop/switch region; other site 498214002722 FtsX-like permease family; Region: FtsX; pfam02687 498214002723 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 498214002724 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 498214002725 FtsX-like permease family; Region: FtsX; pfam02687 498214002726 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214002727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214002728 active site 498214002729 phosphorylation site [posttranslational modification] 498214002730 intermolecular recognition site; other site 498214002731 dimerization interface [polypeptide binding]; other site 498214002732 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214002733 DNA binding site [nucleotide binding] 498214002734 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214002735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214002736 dimer interface [polypeptide binding]; other site 498214002737 phosphorylation site [posttranslational modification] 498214002738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214002739 ATP binding site [chemical binding]; other site 498214002740 Mg2+ binding site [ion binding]; other site 498214002741 G-X-G motif; other site 498214002742 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 498214002743 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 498214002744 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498214002745 4Fe-4S binding domain; Region: Fer4; pfam00037 498214002746 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 498214002747 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 498214002748 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 498214002749 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 498214002750 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 498214002751 dihydrodipicolinate reductase; Provisional; Region: PRK00048 498214002752 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 498214002753 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 498214002754 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 498214002755 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 498214002756 active site residue [active] 498214002757 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 498214002758 active site residue [active] 498214002759 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 498214002760 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 498214002761 nudix motif; other site 498214002762 Protein of unknown function (DUF523); Region: DUF523; pfam04463 498214002763 AAA domain; Region: AAA_33; pfam13671 498214002764 AAA domain; Region: AAA_17; pfam13207 498214002765 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 498214002766 Beta-lactamase; Region: Beta-lactamase; pfam00144 498214002767 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 498214002768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214002769 non-specific DNA binding site [nucleotide binding]; other site 498214002770 salt bridge; other site 498214002771 sequence-specific DNA binding site [nucleotide binding]; other site 498214002772 VanZ like family; Region: VanZ; pfam04892 498214002773 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 498214002774 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 498214002775 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 498214002776 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 498214002777 active site 498214002778 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 498214002779 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498214002780 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214002781 dimer interface [polypeptide binding]; other site 498214002782 putative CheW interface [polypeptide binding]; other site 498214002783 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 498214002784 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 498214002785 FeoA domain; Region: FeoA; pfam04023 498214002786 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 498214002787 GTP/Mg2+ binding site [chemical binding]; other site 498214002788 G5 box; other site 498214002789 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 498214002790 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 498214002791 G1 box; other site 498214002792 G1 box; other site 498214002793 GTP/Mg2+ binding site [chemical binding]; other site 498214002794 Switch I region; other site 498214002795 G2 box; other site 498214002796 G3 box; other site 498214002797 Switch II region; other site 498214002798 G4 box; other site 498214002799 G5 box; other site 498214002800 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 498214002801 Nucleoside recognition; Region: Gate; pfam07670 498214002802 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 498214002803 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 498214002804 catalytic core [active] 498214002805 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 498214002806 VanW like protein; Region: VanW; pfam04294 498214002807 G5 domain; Region: G5; pfam07501 498214002808 cobalamin synthase; Reviewed; Region: cobS; PRK00235 498214002809 AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586 498214002810 Coat F domain; Region: Coat_F; pfam07875 498214002811 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 498214002812 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 498214002813 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 498214002814 NodB motif; other site 498214002815 putative active site [active] 498214002816 putative catalytic site [active] 498214002817 putative Zn binding site [ion binding]; other site 498214002818 This putative domain contains a quite highly conserved sequence of CGGC in its central region; Region: CGGC; smart01078 498214002819 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 498214002820 active site 498214002821 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 498214002822 dihydropteroate synthase; Region: DHPS; TIGR01496 498214002823 substrate binding pocket [chemical binding]; other site 498214002824 dimer interface [polypeptide binding]; other site 498214002825 inhibitor binding site; inhibition site 498214002826 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 498214002827 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 498214002828 catalytic center binding site [active] 498214002829 ATP binding site [chemical binding]; other site 498214002830 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 498214002831 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 498214002832 putative dimer interface [polypeptide binding]; other site 498214002833 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 498214002834 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 498214002835 DNA binding residues [nucleotide binding] 498214002836 dimer interface [polypeptide binding]; other site 498214002837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214002838 S-adenosylmethionine binding site [chemical binding]; other site 498214002839 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 498214002840 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 498214002841 inhibitor-cofactor binding pocket; inhibition site 498214002842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214002843 catalytic residue [active] 498214002844 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 498214002845 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 498214002846 inhibitor-cofactor binding pocket; inhibition site 498214002847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214002848 catalytic residue [active] 498214002849 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 498214002850 Cadmium resistance transporter; Region: Cad; pfam03596 498214002851 CAAX protease self-immunity; Region: Abi; pfam02517 498214002852 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 498214002853 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 498214002854 catalytic residue [active] 498214002855 putative FPP diphosphate binding site; other site 498214002856 putative FPP binding hydrophobic cleft; other site 498214002857 dimer interface [polypeptide binding]; other site 498214002858 putative IPP diphosphate binding site; other site 498214002859 Protein of unknown function (DUF1847); Region: DUF1847; pfam08901 498214002860 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 498214002861 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498214002862 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498214002863 DNA binding residues [nucleotide binding] 498214002864 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 498214002865 SdpI/YhfL protein family; Region: SdpI; pfam13630 498214002866 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 498214002867 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 498214002868 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 498214002869 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 498214002870 Cadmium resistance transporter; Region: Cad; pfam03596 498214002871 Protein of unknown function (DUF523); Region: DUF523; pfam04463 498214002872 Uncharacterized conserved protein [Function unknown]; Region: COG2128 498214002873 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 498214002874 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 498214002875 putative DNA binding site [nucleotide binding]; other site 498214002876 putative Zn2+ binding site [ion binding]; other site 498214002877 AsnC family; Region: AsnC_trans_reg; pfam01037 498214002878 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 498214002879 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 498214002880 SdpI/YhfL protein family; Region: SdpI; pfam13630 498214002881 CAAX protease self-immunity; Region: Abi; cl00558 498214002882 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 498214002883 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 498214002884 catalytic triad [active] 498214002885 catalytic triad [active] 498214002886 oxyanion hole [active] 498214002887 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 498214002888 dinuclear metal binding motif [ion binding]; other site 498214002889 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 498214002890 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 498214002891 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 498214002892 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 498214002893 Walker A/P-loop; other site 498214002894 ATP binding site [chemical binding]; other site 498214002895 Q-loop/lid; other site 498214002896 ABC transporter signature motif; other site 498214002897 Walker B; other site 498214002898 D-loop; other site 498214002899 H-loop/switch region; other site 498214002900 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 498214002901 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214002902 non-specific DNA binding site [nucleotide binding]; other site 498214002903 salt bridge; other site 498214002904 sequence-specific DNA binding site [nucleotide binding]; other site 498214002905 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 498214002906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214002907 Coenzyme A binding pocket [chemical binding]; other site 498214002908 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 498214002909 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 498214002910 metal binding triad [ion binding]; metal-binding site 498214002911 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 498214002912 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 498214002913 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 498214002914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 498214002915 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 498214002916 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 498214002917 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 498214002918 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 498214002919 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 498214002920 DNA binding residues [nucleotide binding] 498214002921 dimer interface [polypeptide binding]; other site 498214002922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214002923 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 498214002924 Coenzyme A binding pocket [chemical binding]; other site 498214002925 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 498214002926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214002927 Coenzyme A binding pocket [chemical binding]; other site 498214002928 Pirin-related protein [General function prediction only]; Region: COG1741 498214002929 Pirin; Region: Pirin; pfam02678 498214002930 Predicted transcriptional regulators [Transcription]; Region: COG1733 498214002931 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 498214002932 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 498214002933 dimer interface [polypeptide binding]; other site 498214002934 FMN binding site [chemical binding]; other site 498214002935 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 498214002936 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 498214002937 Cupin; Region: Cupin_1; smart00835 498214002938 Cupin; Region: Cupin_1; smart00835 498214002939 TIGR00730 family protein; Region: TIGR00730 498214002940 Protein of unknown function, DUF606; Region: DUF606; pfam04657 498214002941 Transcriptional regulator [Transcription]; Region: LysR; COG0583 498214002942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 498214002943 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 498214002944 dimerization interface [polypeptide binding]; other site 498214002945 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 498214002946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214002947 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 498214002948 Coenzyme A binding pocket [chemical binding]; other site 498214002949 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 498214002950 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498214002951 motif II; other site 498214002952 Protein of unknown function, DUF606; Region: DUF606; pfam04657 498214002953 Protein of unknown function, DUF606; Region: DUF606; pfam04657 498214002954 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 498214002955 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 498214002956 ligand binding site [chemical binding]; other site 498214002957 flexible hinge region; other site 498214002958 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 498214002959 putative switch regulator; other site 498214002960 DNA binding site [nucleotide binding] 498214002961 sequence specific DNA binding site [nucleotide binding]; other site 498214002962 putative cAMP binding site [chemical binding]; other site 498214002963 Transcriptional regulator [Transcription]; Region: LysR; COG0583 498214002964 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 498214002965 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 498214002966 dimerization interface [polypeptide binding]; other site 498214002967 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 498214002968 putative FMN binding site [chemical binding]; other site 498214002969 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 498214002970 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 498214002971 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 498214002972 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 498214002973 Uncharacterized conserved protein [Function unknown]; Region: COG2966 498214002974 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 498214002975 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 498214002976 active site 498214002977 catalytic residues [active] 498214002978 metal binding site [ion binding]; metal-binding site 498214002979 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 498214002980 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214002981 DNA-binding site [nucleotide binding]; DNA binding site 498214002982 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498214002983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214002984 homodimer interface [polypeptide binding]; other site 498214002985 catalytic residue [active] 498214002986 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214002987 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214002988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214002989 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 498214002990 putative FMN binding site [chemical binding]; other site 498214002991 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 498214002992 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 498214002993 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 498214002994 Mg++ binding site [ion binding]; other site 498214002995 putative catalytic motif [active] 498214002996 putative substrate binding site [chemical binding]; other site 498214002997 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 498214002998 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214002999 non-specific DNA binding site [nucleotide binding]; other site 498214003000 sequence-specific DNA binding site [nucleotide binding]; other site 498214003001 salt bridge; other site 498214003002 Rrf2 family protein; Region: rrf2_super; TIGR00738 498214003003 Transcriptional regulator; Region: Rrf2; pfam02082 498214003004 S-adenosylmethionine binding site [chemical binding]; other site 498214003005 Methyltransferase domain; Region: Methyltransf_23; pfam13489 498214003006 Methyltransferase domain; Region: Methyltransf_11; pfam08241 498214003007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498214003008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498214003009 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 498214003010 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214003011 FeS/SAM binding site; other site 498214003012 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 498214003013 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 498214003014 DNA binding residues [nucleotide binding] 498214003015 dimer interface [polypeptide binding]; other site 498214003016 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 498214003017 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816 498214003018 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 498214003019 putative hexamer interface [polypeptide binding]; other site 498214003020 putative hexagonal pore; other site 498214003021 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 498214003022 putative hexamer interface [polypeptide binding]; other site 498214003023 putative hexagonal pore; other site 498214003024 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 498214003025 active site 498214003026 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 498214003027 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214003028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214003029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 498214003030 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 498214003031 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 498214003032 FAD binding domain; Region: FAD_binding_4; pfam01565 498214003033 Berberine and berberine like; Region: BBE; pfam08031 498214003034 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 498214003035 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 498214003036 Predicted membrane protein [Function unknown]; Region: COG2510 498214003037 Predicted membrane protein [Function unknown]; Region: COG2510 498214003038 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 498214003039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 498214003040 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 498214003041 YmaF family; Region: YmaF; pfam12788 498214003042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 498214003043 ornithine cyclodeaminase; Validated; Region: PRK07589 498214003044 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 498214003045 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 498214003046 EamA-like transporter family; Region: EamA; pfam00892 498214003047 EamA-like transporter family; Region: EamA; pfam00892 498214003048 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 498214003049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214003050 non-specific DNA binding site [nucleotide binding]; other site 498214003051 salt bridge; other site 498214003052 sequence-specific DNA binding site [nucleotide binding]; other site 498214003053 Cupin domain; Region: Cupin_2; pfam07883 498214003054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214003055 non-specific DNA binding site [nucleotide binding]; other site 498214003056 salt bridge; other site 498214003057 sequence-specific DNA binding site [nucleotide binding]; other site 498214003058 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 498214003059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214003060 Coenzyme A binding pocket [chemical binding]; other site 498214003061 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214003062 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498214003063 Walker A/P-loop; other site 498214003064 ATP binding site [chemical binding]; other site 498214003065 Q-loop/lid; other site 498214003066 ABC transporter signature motif; other site 498214003067 Walker B; other site 498214003068 D-loop; other site 498214003069 H-loop/switch region; other site 498214003070 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 498214003071 FtsX-like permease family; Region: FtsX; pfam02687 498214003072 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214003073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214003074 active site 498214003075 phosphorylation site [posttranslational modification] 498214003076 intermolecular recognition site; other site 498214003077 dimerization interface [polypeptide binding]; other site 498214003078 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214003079 DNA binding site [nucleotide binding] 498214003080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214003081 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214003082 dimerization interface [polypeptide binding]; other site 498214003083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214003084 dimer interface [polypeptide binding]; other site 498214003085 phosphorylation site [posttranslational modification] 498214003086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214003087 ATP binding site [chemical binding]; other site 498214003088 Mg2+ binding site [ion binding]; other site 498214003089 G-X-G motif; other site 498214003090 BioY family; Region: BioY; pfam02632 498214003091 TPR repeat; Region: TPR_11; pfam13414 498214003092 Sel1-like repeats; Region: SEL1; smart00671 498214003093 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 498214003094 Sel1-like repeats; Region: SEL1; smart00671 498214003095 Sel1-like repeats; Region: SEL1; smart00671 498214003096 Sel1-like repeats; Region: SEL1; smart00671 498214003097 putative acetyltransferase YhhY; Provisional; Region: PRK10140 498214003098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214003099 Coenzyme A binding pocket [chemical binding]; other site 498214003100 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 498214003101 Catalytic site [active] 498214003102 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 498214003103 homotrimer interface [polypeptide binding]; other site 498214003104 Walker A motif; other site 498214003105 GTP binding site [chemical binding]; other site 498214003106 Walker B motif; other site 498214003107 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 498214003108 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 498214003109 DNA binding residues [nucleotide binding] 498214003110 dimer interface [polypeptide binding]; other site 498214003111 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 498214003112 cobyric acid synthase; Provisional; Region: PRK00784 498214003113 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498214003114 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498214003115 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 498214003116 catalytic triad [active] 498214003117 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 498214003118 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 498214003119 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498214003120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214003121 homodimer interface [polypeptide binding]; other site 498214003122 catalytic residue [active] 498214003123 cobalt transport protein CbiM; Validated; Region: PRK08319 498214003124 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 498214003125 cobalt transport protein CbiN; Provisional; Region: PRK02898 498214003126 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 498214003127 precorrin-2 dehydrogenase; Provisional; Region: PRK05562 498214003128 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 498214003129 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 498214003130 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 498214003131 domain interfaces; other site 498214003132 active site 498214003133 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 498214003134 active site 498214003135 SAM binding site [chemical binding]; other site 498214003136 homodimer interface [polypeptide binding]; other site 498214003137 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 498214003138 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 498214003139 active site 498214003140 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 498214003141 dimer interface [polypeptide binding]; other site 498214003142 active site 498214003143 Schiff base residues; other site 498214003144 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 498214003145 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 498214003146 catalytic triad [active] 498214003147 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 498214003148 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 498214003149 precorrin-8X methylmutase; Validated; Region: cbiC; PRK05575 498214003150 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 498214003151 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 498214003152 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 498214003153 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498214003154 Predicted ATPase [General function prediction only]; Region: COG3910 498214003155 ATP-binding cassette domain of non-transporter proteins; Region: ABC_Class2; cd03227 498214003156 Walker A/P-loop; other site 498214003157 ATP binding site [chemical binding]; other site 498214003158 Q-loop/lid; other site 498214003159 ABC transporter signature motif; other site 498214003160 Walker B; other site 498214003161 D-loop; other site 498214003162 H-loop/switch region; other site 498214003163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214003164 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 498214003165 Coenzyme A binding pocket [chemical binding]; other site 498214003166 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 498214003167 FMN binding site [chemical binding]; other site 498214003168 dimer interface [polypeptide binding]; other site 498214003169 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 498214003170 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 498214003171 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 498214003172 active site 498214003173 putative homodimer interface [polypeptide binding]; other site 498214003174 SAM binding site [chemical binding]; other site 498214003175 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 498214003176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214003177 S-adenosylmethionine binding site [chemical binding]; other site 498214003178 hypothetical protein; Provisional; Region: PRK06771 498214003179 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 498214003180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214003181 Coenzyme A binding pocket [chemical binding]; other site 498214003182 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 498214003183 active site 498214003184 SAM binding site [chemical binding]; other site 498214003185 homodimer interface [polypeptide binding]; other site 498214003186 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 498214003187 active site 498214003188 SAM binding site [chemical binding]; other site 498214003189 homodimer interface [polypeptide binding]; other site 498214003190 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 498214003191 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 498214003192 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 498214003193 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 498214003194 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 498214003195 active site 498214003196 SAM binding site [chemical binding]; other site 498214003197 homodimer interface [polypeptide binding]; other site 498214003198 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 498214003199 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 498214003200 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 498214003201 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 498214003202 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 498214003203 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 498214003204 active site 498214003205 C-terminal domain interface [polypeptide binding]; other site 498214003206 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 498214003207 active site 498214003208 N-terminal domain interface [polypeptide binding]; other site 498214003209 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 498214003210 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 498214003211 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 498214003212 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 498214003213 homodimer interface [polypeptide binding]; other site 498214003214 Walker A motif; other site 498214003215 ATP binding site [chemical binding]; other site 498214003216 hydroxycobalamin binding site [chemical binding]; other site 498214003217 Walker B motif; other site 498214003218 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 498214003219 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 498214003220 ligand binding site [chemical binding]; other site 498214003221 flexible hinge region; other site 498214003222 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 498214003223 putative switch regulator; other site 498214003224 non-specific DNA interactions [nucleotide binding]; other site 498214003225 DNA binding site [nucleotide binding] 498214003226 sequence specific DNA binding site [nucleotide binding]; other site 498214003227 putative cAMP binding site [chemical binding]; other site 498214003228 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 498214003229 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 498214003230 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 498214003231 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 498214003232 FAD binding pocket [chemical binding]; other site 498214003233 FAD binding motif [chemical binding]; other site 498214003234 phosphate binding motif [ion binding]; other site 498214003235 beta-alpha-beta structure motif; other site 498214003236 NAD binding pocket [chemical binding]; other site 498214003237 Iron coordination center [ion binding]; other site 498214003238 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 498214003239 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 498214003240 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214003241 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498214003242 Walker A/P-loop; other site 498214003243 ATP binding site [chemical binding]; other site 498214003244 Q-loop/lid; other site 498214003245 ABC transporter signature motif; other site 498214003246 Walker B; other site 498214003247 D-loop; other site 498214003248 H-loop/switch region; other site 498214003249 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214003250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214003251 active site 498214003252 phosphorylation site [posttranslational modification] 498214003253 intermolecular recognition site; other site 498214003254 dimerization interface [polypeptide binding]; other site 498214003255 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214003256 DNA binding site [nucleotide binding] 498214003257 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214003258 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214003259 dimerization interface [polypeptide binding]; other site 498214003260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214003261 dimer interface [polypeptide binding]; other site 498214003262 phosphorylation site [posttranslational modification] 498214003263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214003264 ATP binding site [chemical binding]; other site 498214003265 Mg2+ binding site [ion binding]; other site 498214003266 G-X-G motif; other site 498214003267 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 498214003268 putative MPT binding site; other site 498214003269 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 498214003270 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 498214003271 substrate binding pocket [chemical binding]; other site 498214003272 membrane-bound complex binding site; other site 498214003273 hinge residues; other site 498214003274 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 498214003275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214003276 dimer interface [polypeptide binding]; other site 498214003277 conserved gate region; other site 498214003278 putative PBP binding loops; other site 498214003279 ABC-ATPase subunit interface; other site 498214003280 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214003281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214003282 Walker A/P-loop; other site 498214003283 ATP binding site [chemical binding]; other site 498214003284 Q-loop/lid; other site 498214003285 ABC transporter signature motif; other site 498214003286 Walker B; other site 498214003287 D-loop; other site 498214003288 H-loop/switch region; other site 498214003289 Domain of unknown function (DUF364); Region: DUF364; pfam04016 498214003290 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 498214003291 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 498214003292 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 498214003293 Walker A/P-loop; other site 498214003294 ATP binding site [chemical binding]; other site 498214003295 Q-loop/lid; other site 498214003296 ABC transporter signature motif; other site 498214003297 Walker B; other site 498214003298 D-loop; other site 498214003299 H-loop/switch region; other site 498214003300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214003301 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214003302 active site 498214003303 phosphorylation site [posttranslational modification] 498214003304 intermolecular recognition site; other site 498214003305 dimerization interface [polypeptide binding]; other site 498214003306 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214003307 DNA binding site [nucleotide binding] 498214003308 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214003309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214003310 dimer interface [polypeptide binding]; other site 498214003311 phosphorylation site [posttranslational modification] 498214003312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214003313 ATP binding site [chemical binding]; other site 498214003314 G-X-G motif; other site 498214003315 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 498214003316 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 498214003317 Walker A/P-loop; other site 498214003318 ATP binding site [chemical binding]; other site 498214003319 Q-loop/lid; other site 498214003320 ABC transporter signature motif; other site 498214003321 Walker B; other site 498214003322 D-loop; other site 498214003323 H-loop/switch region; other site 498214003324 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 498214003325 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 498214003326 ABC-ATPase subunit interface; other site 498214003327 dimer interface [polypeptide binding]; other site 498214003328 putative PBP binding regions; other site 498214003329 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 498214003330 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 498214003331 putative ligand binding residues [chemical binding]; other site 498214003332 Predicted transcriptional regulator [Transcription]; Region: COG2378 498214003333 HTH domain; Region: HTH_11; pfam08279 498214003334 WYL domain; Region: WYL; pfam13280 498214003335 Transcriptional regulator [Transcription]; Region: LysR; COG0583 498214003336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 498214003337 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 498214003338 dimerization interface [polypeptide binding]; other site 498214003339 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 498214003340 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 498214003341 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498214003342 catalytic residue [active] 498214003343 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 498214003344 dihydroxyacetone kinase; Provisional; Region: PRK14479 498214003345 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 498214003346 DAK2 domain; Region: Dak2; pfam02734 498214003347 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 498214003348 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 498214003349 dimer interface [polypeptide binding]; other site 498214003350 active site 498214003351 metal binding site [ion binding]; metal-binding site 498214003352 Sensory domain found in PocR; Region: PocR; pfam10114 498214003353 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 498214003354 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214003355 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214003356 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214003357 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 498214003358 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214003359 Coenzyme A binding pocket [chemical binding]; other site 498214003360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214003361 Coenzyme A binding pocket [chemical binding]; other site 498214003362 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 498214003363 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 498214003364 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 498214003365 active site 498214003366 catalytic tetrad [active] 498214003367 TfoX N-terminal domain; Region: TfoX_N; pfam04993 498214003368 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 498214003369 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 498214003370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214003371 Coenzyme A binding pocket [chemical binding]; other site 498214003372 Predicted transcriptional regulators [Transcription]; Region: COG1695 498214003373 Transcriptional regulator PadR-like family; Region: PadR; cl17335 498214003374 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 498214003375 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 498214003376 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 498214003377 active site 498214003378 purine riboside binding site [chemical binding]; other site 498214003379 Predicted membrane protein [Function unknown]; Region: COG1511 498214003380 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 498214003381 Predicted membrane protein [Function unknown]; Region: COG1511 498214003382 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 498214003383 Predicted membrane protein [Function unknown]; Region: COG1511 498214003384 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 498214003385 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 498214003386 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 498214003387 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 498214003388 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 498214003389 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498214003390 ATP binding site [chemical binding]; other site 498214003391 putative Mg++ binding site [ion binding]; other site 498214003392 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498214003393 nucleotide binding region [chemical binding]; other site 498214003394 ATP-binding site [chemical binding]; other site 498214003395 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 498214003396 HRDC domain; Region: HRDC; pfam00570 498214003397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 498214003398 Rubrerythrin [Energy production and conversion]; Region: COG1592 498214003399 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 498214003400 diiron binding motif [ion binding]; other site 498214003401 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 498214003402 active site 498214003403 metal binding site [ion binding]; metal-binding site 498214003404 homotetramer interface [polypeptide binding]; other site 498214003405 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 498214003406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214003407 active site 498214003408 phosphorylation site [posttranslational modification] 498214003409 intermolecular recognition site; other site 498214003410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 498214003411 TPR repeat; Region: TPR_11; pfam13414 498214003412 TPR motif; other site 498214003413 binding surface 498214003414 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 498214003415 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 498214003416 L-lactate permease; Region: Lactate_perm; cl00701 498214003417 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 498214003418 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 498214003419 Ligand binding site [chemical binding]; other site 498214003420 Electron transfer flavoprotein domain; Region: ETF; pfam01012 498214003421 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 498214003422 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 498214003423 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 498214003424 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 498214003425 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 498214003426 FAD binding domain; Region: FAD_binding_4; pfam01565 498214003427 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 498214003428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214003429 active site 498214003430 phosphorylation site [posttranslational modification] 498214003431 intermolecular recognition site; other site 498214003432 dimerization interface [polypeptide binding]; other site 498214003433 LytTr DNA-binding domain; Region: LytTR; pfam04397 498214003434 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 498214003435 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 498214003436 Accessory gene regulator B; Region: AgrB; pfam04647 498214003437 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 498214003438 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 498214003439 Putative cyclase; Region: Cyclase; pfam04199 498214003440 aspartate aminotransferase; Provisional; Region: PRK06836 498214003441 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498214003442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214003443 homodimer interface [polypeptide binding]; other site 498214003444 catalytic residue [active] 498214003445 Putative cyclase; Region: Cyclase; pfam04199 498214003446 Putative cyclase; Region: Cyclase; cl00814 498214003447 MarR family; Region: MarR; pfam01047 498214003448 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 498214003449 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 498214003450 DNA binding residues [nucleotide binding] 498214003451 drug binding residues [chemical binding]; other site 498214003452 dimer interface [polypeptide binding]; other site 498214003453 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 498214003454 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 498214003455 B3/4 domain; Region: B3_4; pfam03483 498214003456 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 498214003457 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 498214003458 Dimer interface [polypeptide binding]; other site 498214003459 anticodon binding site; other site 498214003460 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 498214003461 homodimer interface [polypeptide binding]; other site 498214003462 motif 1; other site 498214003463 motif 2; other site 498214003464 active site 498214003465 motif 3; other site 498214003466 flavodoxin; Provisional; Region: PRK06242 498214003467 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 498214003468 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498214003469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498214003470 WHG domain; Region: WHG; pfam13305 498214003471 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 498214003472 dUMP phosphatase; Provisional; Region: PRK09449 498214003473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498214003474 motif II; other site 498214003475 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 498214003476 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 498214003477 ligand binding site [chemical binding]; other site 498214003478 flexible hinge region; other site 498214003479 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 498214003480 putative switch regulator; other site 498214003481 DNA binding site [nucleotide binding] 498214003482 sequence specific DNA binding site [nucleotide binding]; other site 498214003483 putative cAMP binding site [chemical binding]; other site 498214003484 DJ-1 family protein; Region: not_thiJ; TIGR01383 498214003485 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 498214003486 conserved cys residue [active] 498214003487 Transcriptional regulator [Transcription]; Region: LysR; COG0583 498214003488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 498214003489 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 498214003490 dimerization interface [polypeptide binding]; other site 498214003491 YoaP-like; Region: YoaP; pfam14268 498214003492 FeoA domain; Region: FeoA; pfam04023 498214003493 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 498214003494 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 498214003495 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 498214003496 G1 box; other site 498214003497 GTP/Mg2+ binding site [chemical binding]; other site 498214003498 Switch I region; other site 498214003499 G2 box; other site 498214003500 G3 box; other site 498214003501 Switch II region; other site 498214003502 G4 box; other site 498214003503 G5 box; other site 498214003504 Nucleoside recognition; Region: Gate; pfam07670 498214003505 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 498214003506 Nucleoside recognition; Region: Gate; pfam07670 498214003507 Predicted membrane protein [Function unknown]; Region: COG2323 498214003508 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 498214003509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214003510 Coenzyme A binding pocket [chemical binding]; other site 498214003511 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 498214003512 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 498214003513 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 498214003514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498214003515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498214003516 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 498214003517 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 498214003518 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 498214003519 active site 498214003520 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214003521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214003522 active site 498214003523 phosphorylation site [posttranslational modification] 498214003524 intermolecular recognition site; other site 498214003525 dimerization interface [polypeptide binding]; other site 498214003526 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214003527 DNA binding site [nucleotide binding] 498214003528 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214003529 dimer interface [polypeptide binding]; other site 498214003530 phosphorylation site [posttranslational modification] 498214003531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214003532 ATP binding site [chemical binding]; other site 498214003533 Mg2+ binding site [ion binding]; other site 498214003534 G-X-G motif; other site 498214003535 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 498214003536 Cytochrome P450; Region: p450; cl12078 498214003537 Cytochrome P450; Region: p450; cl12078 498214003538 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 498214003539 metal-binding site [ion binding] 498214003540 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 498214003541 Family description; Region: DsbD_2; pfam13386 498214003542 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 498214003543 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 498214003544 Predicted membrane protein [Function unknown]; Region: COG3462 498214003545 Short C-terminal domain; Region: SHOCT; pfam09851 498214003546 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214003547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214003548 active site 498214003549 phosphorylation site [posttranslational modification] 498214003550 intermolecular recognition site; other site 498214003551 dimerization interface [polypeptide binding]; other site 498214003552 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214003553 DNA binding site [nucleotide binding] 498214003554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214003555 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214003556 dimerization interface [polypeptide binding]; other site 498214003557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214003558 dimer interface [polypeptide binding]; other site 498214003559 phosphorylation site [posttranslational modification] 498214003560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214003561 ATP binding site [chemical binding]; other site 498214003562 Mg2+ binding site [ion binding]; other site 498214003563 G-X-G motif; other site 498214003564 A new structural DNA glycosylase; Region: AlkD_like; cd06561 498214003565 active site 498214003566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214003567 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214003568 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214003569 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 498214003570 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 498214003571 ABC-ATPase subunit interface; other site 498214003572 dimer interface [polypeptide binding]; other site 498214003573 putative PBP binding regions; other site 498214003574 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 498214003575 ABC-ATPase subunit interface; other site 498214003576 dimer interface [polypeptide binding]; other site 498214003577 putative PBP binding regions; other site 498214003578 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 498214003579 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 498214003580 Walker A/P-loop; other site 498214003581 ATP binding site [chemical binding]; other site 498214003582 Q-loop/lid; other site 498214003583 ABC transporter signature motif; other site 498214003584 Walker B; other site 498214003585 D-loop; other site 498214003586 H-loop/switch region; other site 498214003587 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 498214003588 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 498214003589 putative ligand binding residues [chemical binding]; other site 498214003590 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214003591 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214003592 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 498214003593 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 498214003594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214003595 Walker A/P-loop; other site 498214003596 ATP binding site [chemical binding]; other site 498214003597 Q-loop/lid; other site 498214003598 ABC transporter signature motif; other site 498214003599 Walker B; other site 498214003600 D-loop; other site 498214003601 H-loop/switch region; other site 498214003602 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 498214003603 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 498214003604 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 498214003605 Walker A/P-loop; other site 498214003606 ATP binding site [chemical binding]; other site 498214003607 Q-loop/lid; other site 498214003608 ABC transporter signature motif; other site 498214003609 Walker B; other site 498214003610 D-loop; other site 498214003611 H-loop/switch region; other site 498214003612 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 498214003613 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 498214003614 ATP binding site [chemical binding]; other site 498214003615 Mg2+ binding site [ion binding]; other site 498214003616 G-X-G motif; other site 498214003617 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 498214003618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214003619 active site 498214003620 phosphorylation site [posttranslational modification] 498214003621 intermolecular recognition site; other site 498214003622 dimerization interface [polypeptide binding]; other site 498214003623 LytTr DNA-binding domain; Region: LytTR; smart00850 498214003624 Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848 498214003625 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 498214003626 conserved repeat domain; Region: B_ant_repeat; TIGR01451 498214003627 Domain of unknown function DUF11; Region: DUF11; pfam01345 498214003628 Domain of unknown function DUF11; Region: DUF11; cl17728 498214003629 Domain of unknown function DUF11; Region: DUF11; pfam01345 498214003630 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 498214003631 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 498214003632 catalytic residues [active] 498214003633 Predicted membrane protein [Function unknown]; Region: COG4129 498214003634 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 498214003635 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 498214003636 Predicted Ser/Thr protein kinase [Signal transduction mechanisms]; Region: COG2112 498214003637 CAAX protease self-immunity; Region: Abi; pfam02517 498214003638 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 498214003639 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 498214003640 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214003641 Walker A/P-loop; other site 498214003642 ATP binding site [chemical binding]; other site 498214003643 Q-loop/lid; other site 498214003644 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498214003645 ABC transporter signature motif; other site 498214003646 Walker B; other site 498214003647 ABC transporter; Region: ABC_tran_2; pfam12848 498214003648 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498214003649 Nucleoside recognition; Region: Gate; pfam07670 498214003650 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 498214003651 ArsC family; Region: ArsC; pfam03960 498214003652 catalytic residue [active] 498214003653 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214003654 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 498214003655 FeS/SAM binding site; other site 498214003656 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 498214003657 Predicted dehydrogenase [General function prediction only]; Region: COG0579 498214003658 hydroxyglutarate oxidase; Provisional; Region: PRK11728 498214003659 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 498214003660 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 498214003661 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 498214003662 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 498214003663 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 498214003664 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 498214003665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498214003666 putative substrate translocation pore; other site 498214003667 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 498214003668 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 498214003669 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 498214003670 active site 498214003671 HIGH motif; other site 498214003672 KMSK motif region; other site 498214003673 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 498214003674 tRNA binding surface [nucleotide binding]; other site 498214003675 anticodon binding site; other site 498214003676 transaminase; Validated; Region: PRK07324 498214003677 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498214003678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214003679 homodimer interface [polypeptide binding]; other site 498214003680 catalytic residue [active] 498214003681 FOG: CBS domain [General function prediction only]; Region: COG0517 498214003682 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 498214003683 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 498214003684 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 498214003685 G1 box; other site 498214003686 GTP/Mg2+ binding site [chemical binding]; other site 498214003687 Switch I region; other site 498214003688 G2 box; other site 498214003689 G3 box; other site 498214003690 Switch II region; other site 498214003691 G4 box; other site 498214003692 G5 box; other site 498214003693 Nucleoside recognition; Region: Gate; pfam07670 498214003694 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 498214003695 Nucleoside recognition; Region: Gate; pfam07670 498214003696 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 498214003697 PilZ domain; Region: PilZ; pfam07238 498214003698 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 498214003699 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498214003700 motif II; other site 498214003701 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 498214003702 active site 498214003703 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 498214003704 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 498214003705 aromatic chitin/cellulose binding site residues [chemical binding]; other site 498214003706 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 498214003707 aromatic chitin/cellulose binding site residues [chemical binding]; other site 498214003708 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 498214003709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214003710 Coenzyme A binding pocket [chemical binding]; other site 498214003711 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 498214003712 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 498214003713 Walker A/P-loop; other site 498214003714 ATP binding site [chemical binding]; other site 498214003715 Q-loop/lid; other site 498214003716 ABC transporter signature motif; other site 498214003717 Walker B; other site 498214003718 D-loop; other site 498214003719 H-loop/switch region; other site 498214003720 NIL domain; Region: NIL; pfam09383 498214003721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214003722 dimer interface [polypeptide binding]; other site 498214003723 conserved gate region; other site 498214003724 ABC-ATPase subunit interface; other site 498214003725 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 498214003726 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 498214003727 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 498214003728 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 498214003729 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 498214003730 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 498214003731 metal binding site [ion binding]; metal-binding site 498214003732 putative dimer interface [polypeptide binding]; other site 498214003733 RNase_H superfamily; Region: RNase_H_2; pfam13482 498214003734 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498214003735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498214003736 Transcriptional regulators [Transcription]; Region: FadR; COG2186 498214003737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214003738 DNA-binding site [nucleotide binding]; DNA binding site 498214003739 FCD domain; Region: FCD; pfam07729 498214003740 Uncharacterized conserved protein [Function unknown]; Region: COG1284 498214003741 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 498214003742 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 498214003743 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 498214003744 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 498214003745 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 498214003746 active site 498214003747 HIGH motif; other site 498214003748 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 498214003749 active site 498214003750 KMSKS motif; other site 498214003751 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 498214003752 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 498214003753 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 498214003754 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 498214003755 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498214003756 Beta-Casp domain; Region: Beta-Casp; smart01027 498214003757 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 498214003758 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214003759 Zn2+ binding site [ion binding]; other site 498214003760 Mg2+ binding site [ion binding]; other site 498214003761 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 498214003762 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 498214003763 NAD(P) binding site [chemical binding]; other site 498214003764 catalytic residues [active] 498214003765 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 498214003766 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 498214003767 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 498214003768 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 498214003769 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 498214003770 MarR family; Region: MarR_2; pfam12802 498214003771 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 498214003772 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 498214003773 Tetratricopeptide repeat; Region: TPR_12; pfam13424 498214003774 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 498214003775 hypothetical protein; Provisional; Region: PRK11622 498214003776 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 498214003777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214003778 dimer interface [polypeptide binding]; other site 498214003779 conserved gate region; other site 498214003780 putative PBP binding loops; other site 498214003781 ABC-ATPase subunit interface; other site 498214003782 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 498214003783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214003784 dimer interface [polypeptide binding]; other site 498214003785 conserved gate region; other site 498214003786 putative PBP binding loops; other site 498214003787 ABC-ATPase subunit interface; other site 498214003788 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 498214003789 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 498214003790 Walker A/P-loop; other site 498214003791 ATP binding site [chemical binding]; other site 498214003792 Q-loop/lid; other site 498214003793 ABC transporter signature motif; other site 498214003794 Walker B; other site 498214003795 D-loop; other site 498214003796 H-loop/switch region; other site 498214003797 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 498214003798 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 498214003799 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214003800 Coenzyme A binding pocket [chemical binding]; other site 498214003801 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 498214003802 catalytic residues [active] 498214003803 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 498214003804 maltose O-acetyltransferase; Provisional; Region: PRK10092 498214003805 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 498214003806 active site 498214003807 substrate binding site [chemical binding]; other site 498214003808 trimer interface [polypeptide binding]; other site 498214003809 CoA binding site [chemical binding]; other site 498214003810 Biotin operon repressor [Transcription]; Region: BirA; COG1654 498214003811 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 498214003812 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 498214003813 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 498214003814 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 498214003815 metal-binding site [ion binding] 498214003816 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 498214003817 FOG: CBS domain [General function prediction only]; Region: COG0517 498214003818 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214003819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214003820 dimer interface [polypeptide binding]; other site 498214003821 phosphorylation site [posttranslational modification] 498214003822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214003823 ATP binding site [chemical binding]; other site 498214003824 Mg2+ binding site [ion binding]; other site 498214003825 G-X-G motif; other site 498214003826 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 498214003827 nucleophile elbow; other site 498214003828 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 498214003829 MgtE intracellular N domain; Region: MgtE_N; smart00924 498214003830 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 498214003831 Divalent cation transporter; Region: MgtE; pfam01769 498214003832 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 498214003833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498214003834 catalytic residue [active] 498214003835 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 498214003836 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 498214003837 putative ligand binding site [chemical binding]; other site 498214003838 NAD binding site [chemical binding]; other site 498214003839 dimerization interface [polypeptide binding]; other site 498214003840 catalytic site [active] 498214003841 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 498214003842 Uncharacterized conserved protein [Function unknown]; Region: COG4198 498214003843 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 498214003844 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498214003845 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 498214003846 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 498214003847 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 498214003848 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 498214003849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 498214003850 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 498214003851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 498214003852 BCCT family transporter; Region: BCCT; pfam02028 498214003853 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 498214003854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214003855 DNA-binding site [nucleotide binding]; DNA binding site 498214003856 TrkA-C domain; Region: TrkA_C; pfam02080 498214003857 Flavin Reductases; Region: FlaRed; cl00801 498214003858 Isochorismatase family; Region: Isochorismatase; pfam00857 498214003859 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 498214003860 catalytic triad [active] 498214003861 conserved cis-peptide bond; other site 498214003862 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 498214003863 active site residue [active] 498214003864 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 498214003865 TPR repeat; Region: TPR_11; pfam13414 498214003866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 498214003867 binding surface 498214003868 TPR motif; other site 498214003869 TPR repeat; Region: TPR_11; pfam13414 498214003870 TPR repeat; Region: TPR_11; pfam13414 498214003871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 498214003872 binding surface 498214003873 TPR motif; other site 498214003874 TPR repeat; Region: TPR_11; pfam13414 498214003875 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498214003876 active site 498214003877 Protein of unknown function (DUF3867); Region: DUF3867; pfam12983 498214003878 Rhodanese Homology Domain; Region: RHOD; smart00450 498214003879 active site residue [active] 498214003880 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 498214003881 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 498214003882 active site residue [active] 498214003883 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 498214003884 active site residue [active] 498214003885 Domain of unknown function DUF20; Region: UPF0118; pfam01594 498214003886 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 498214003887 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 498214003888 putative metal binding site [ion binding]; other site 498214003889 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 498214003890 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 498214003891 active site 498214003892 metal-binding site [ion binding] 498214003893 nucleotide-binding site [chemical binding]; other site 498214003894 nucleotide-binding site [chemical binding]; other site 498214003895 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 498214003896 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 498214003897 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 498214003898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214003899 dimer interface [polypeptide binding]; other site 498214003900 conserved gate region; other site 498214003901 putative PBP binding loops; other site 498214003902 ABC-ATPase subunit interface; other site 498214003903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214003904 dimer interface [polypeptide binding]; other site 498214003905 conserved gate region; other site 498214003906 putative PBP binding loops; other site 498214003907 ABC-ATPase subunit interface; other site 498214003908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214003909 Walker A/P-loop; other site 498214003910 ATP binding site [chemical binding]; other site 498214003911 ABC transporter; Region: ABC_tran; pfam00005 498214003912 Q-loop/lid; other site 498214003913 ABC transporter signature motif; other site 498214003914 Walker B; other site 498214003915 D-loop; other site 498214003916 H-loop/switch region; other site 498214003917 TOBE domain; Region: TOBE_2; pfam08402 498214003918 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 498214003919 Double zinc ribbon; Region: DZR; pfam12773 498214003920 Yip1 domain; Region: Yip1; pfam04893 498214003921 Predicted membrane protein [Function unknown]; Region: COG4640 498214003922 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 498214003923 Double zinc ribbon; Region: DZR; pfam12773 498214003924 YARHG domain; Region: YARHG; pfam13308 498214003925 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 498214003926 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 498214003927 RNA binding site [nucleotide binding]; other site 498214003928 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 498214003929 RNA binding site [nucleotide binding]; other site 498214003930 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 498214003931 RNA binding site [nucleotide binding]; other site 498214003932 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 498214003933 RNA binding site [nucleotide binding]; other site 498214003934 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 498214003935 active site 498214003936 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 498214003937 hexamer interface [polypeptide binding]; other site 498214003938 RNA binding site [nucleotide binding]; other site 498214003939 Histidine-zinc binding site [chemical binding]; other site 498214003940 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 498214003941 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 498214003942 zinc binding site [ion binding]; other site 498214003943 putative ligand binding site [chemical binding]; other site 498214003944 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 498214003945 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 498214003946 TM-ABC transporter signature motif; other site 498214003947 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 498214003948 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214003949 Walker A/P-loop; other site 498214003950 ATP binding site [chemical binding]; other site 498214003951 Q-loop/lid; other site 498214003952 ABC transporter signature motif; other site 498214003953 Walker B; other site 498214003954 D-loop; other site 498214003955 H-loop/switch region; other site 498214003956 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 498214003957 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498214003958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214003959 homodimer interface [polypeptide binding]; other site 498214003960 catalytic residue [active] 498214003961 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 498214003962 EamA-like transporter family; Region: EamA; pfam00892 498214003963 EamA-like transporter family; Region: EamA; pfam00892 498214003964 putative kinase; Provisional; Region: PRK09954 498214003965 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 498214003966 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 498214003967 substrate binding site [chemical binding]; other site 498214003968 ATP binding site [chemical binding]; other site 498214003969 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 498214003970 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 498214003971 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 498214003972 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 498214003973 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 498214003974 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 498214003975 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 498214003976 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 498214003977 homodimer interface [polypeptide binding]; other site 498214003978 NADP binding site [chemical binding]; other site 498214003979 substrate binding site [chemical binding]; other site 498214003980 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 498214003981 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498214003982 active site 498214003983 motif I; other site 498214003984 motif II; other site 498214003985 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 498214003986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214003987 Coenzyme A binding pocket [chemical binding]; other site 498214003988 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 498214003989 ZIP Zinc transporter; Region: Zip; pfam02535 498214003990 Predicted transcriptional regulator [Transcription]; Region: COG1959 498214003991 Transcriptional regulator; Region: Rrf2; cl17282 498214003992 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 498214003993 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 498214003994 dimer interface [polypeptide binding]; other site 498214003995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214003996 catalytic residue [active] 498214003997 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 498214003998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214003999 dimer interface [polypeptide binding]; other site 498214004000 conserved gate region; other site 498214004001 putative PBP binding loops; other site 498214004002 ABC-ATPase subunit interface; other site 498214004003 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 498214004004 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 498214004005 substrate binding pocket [chemical binding]; other site 498214004006 membrane-bound complex binding site; other site 498214004007 hinge residues; other site 498214004008 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 498214004009 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 498214004010 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498214004011 catalytic residue [active] 498214004012 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 498214004013 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 498214004014 Ligand Binding Site [chemical binding]; other site 498214004015 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 498214004016 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 498214004017 Ligand Binding Site [chemical binding]; other site 498214004018 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 498214004019 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 498214004020 Protein of unknown function (DUF998); Region: DUF998; pfam06197 498214004021 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 498214004022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214004023 active site 498214004024 phosphorylation site [posttranslational modification] 498214004025 intermolecular recognition site; other site 498214004026 LytTr DNA-binding domain; Region: LytTR; pfam04397 498214004027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214004028 ATP binding site [chemical binding]; other site 498214004029 Mg2+ binding site [ion binding]; other site 498214004030 G-X-G motif; other site 498214004031 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 498214004032 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 498214004033 Walker A/P-loop; other site 498214004034 ATP binding site [chemical binding]; other site 498214004035 Q-loop/lid; other site 498214004036 ABC transporter signature motif; other site 498214004037 Walker B; other site 498214004038 D-loop; other site 498214004039 H-loop/switch region; other site 498214004040 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 498214004041 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 498214004042 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 498214004043 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 498214004044 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 498214004045 active site 498214004046 catalytic site [active] 498214004047 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 498214004048 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 498214004049 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 498214004050 dimer interface [polypeptide binding]; other site 498214004051 PYR/PP interface [polypeptide binding]; other site 498214004052 TPP binding site [chemical binding]; other site 498214004053 substrate binding site [chemical binding]; other site 498214004054 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 498214004055 Domain of unknown function; Region: EKR; pfam10371 498214004056 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498214004057 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 498214004058 TPP-binding site [chemical binding]; other site 498214004059 dimer interface [polypeptide binding]; other site 498214004060 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498214004061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498214004062 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 498214004063 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 498214004064 Uncharacterized conserved protein [Function unknown]; Region: COG0397 498214004065 hypothetical protein; Validated; Region: PRK00029 498214004066 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 498214004067 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 498214004068 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 498214004069 Helix-turn-helix domain; Region: HTH_18; pfam12833 498214004070 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214004071 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 498214004072 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 498214004073 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 498214004074 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 498214004075 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 498214004076 nucleotide binding site [chemical binding]; other site 498214004077 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 498214004078 beta-galactosidase; Region: BGL; TIGR03356 498214004079 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 498214004080 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 498214004081 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 498214004082 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 498214004083 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 498214004084 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 498214004085 dimer interface [polypeptide binding]; other site 498214004086 active site 498214004087 glycine loop; other site 498214004088 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 498214004089 active site 498214004090 intersubunit interactions; other site 498214004091 catalytic residue [active] 498214004092 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; cl03185 498214004093 Beta-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. Beta-amylase has, in addition to its C-terminal CBM20 domain, an N-terminal catalytic domain belonging to glycosyl hydrolase family 14, which hydrolyzes the alpha-1; Region: CBM20_beta_amylase; cd05809 498214004094 starch-binding site 2 [chemical binding]; other site 498214004095 starch-binding site 1 [chemical binding]; other site 498214004096 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 498214004097 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 498214004098 active site 498214004099 HIGH motif; other site 498214004100 dimer interface [polypeptide binding]; other site 498214004101 KMSKS motif; other site 498214004102 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 498214004103 RNA binding surface [nucleotide binding]; other site 498214004104 Predicted transcriptional regulators [Transcription]; Region: COG1725 498214004105 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214004106 DNA-binding site [nucleotide binding]; DNA binding site 498214004107 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 498214004108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214004109 Walker A/P-loop; other site 498214004110 ATP binding site [chemical binding]; other site 498214004111 Q-loop/lid; other site 498214004112 ABC transporter signature motif; other site 498214004113 Walker B; other site 498214004114 D-loop; other site 498214004115 H-loop/switch region; other site 498214004116 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498214004117 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 498214004118 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498214004119 Bacterial SH3 domain; Region: SH3_3; pfam08239 498214004120 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 498214004121 active site 498214004122 PAS domain S-box; Region: sensory_box; TIGR00229 498214004123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498214004124 putative active site [active] 498214004125 heme pocket [chemical binding]; other site 498214004126 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 498214004127 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 498214004128 metal binding site [ion binding]; metal-binding site 498214004129 active site 498214004130 I-site; other site 498214004131 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 498214004132 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 498214004133 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 498214004134 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 498214004135 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 498214004136 Uncharacterized conserved protein [Function unknown]; Region: COG5663 498214004137 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 498214004138 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 498214004139 active site 498214004140 dimer interface [polypeptide binding]; other site 498214004141 Yip1 domain; Region: Yip1; pfam04893 498214004142 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 498214004143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214004144 putative PBP binding loops; other site 498214004145 dimer interface [polypeptide binding]; other site 498214004146 ABC-ATPase subunit interface; other site 498214004147 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 498214004148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214004149 dimer interface [polypeptide binding]; other site 498214004150 conserved gate region; other site 498214004151 putative PBP binding loops; other site 498214004152 ABC-ATPase subunit interface; other site 498214004153 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 498214004154 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 498214004155 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 498214004156 CotJB protein; Region: CotJB; pfam12652 498214004157 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 498214004158 dimanganese center [ion binding]; other site 498214004159 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 498214004160 Tubby C 2; Region: Tub_2; cl02043 498214004161 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 498214004162 trimer interface [polypeptide binding]; other site 498214004163 active site 498214004164 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 498214004165 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 498214004166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214004167 non-specific DNA binding site [nucleotide binding]; other site 498214004168 salt bridge; other site 498214004169 sequence-specific DNA binding site [nucleotide binding]; other site 498214004170 Cupin domain; Region: Cupin_2; pfam07883 498214004171 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 498214004172 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 498214004173 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 498214004174 amino acid carrier protein; Region: agcS; TIGR00835 498214004175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214004176 non-specific DNA binding site [nucleotide binding]; other site 498214004177 salt bridge; other site 498214004178 sequence-specific DNA binding site [nucleotide binding]; other site 498214004179 Helix-turn-helix domain; Region: HTH_17; pfam12728 498214004180 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 498214004181 catalytic residues [active] 498214004182 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 498214004183 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 498214004184 tetrameric interface [polypeptide binding]; other site 498214004185 activator binding site; other site 498214004186 NADP binding site [chemical binding]; other site 498214004187 substrate binding site [chemical binding]; other site 498214004188 catalytic residues [active] 498214004189 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 498214004190 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 498214004191 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 498214004192 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 498214004193 selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918 498214004194 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 498214004195 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 498214004196 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 498214004197 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 498214004198 catalytic residues [active] 498214004199 Glycine reductase complex selenoprotein A; Region: GRDA; cl04705 498214004200 Glycine reductase complex selenoprotein A; Region: GRDA; cl04705 498214004201 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 498214004202 dimer interface [polypeptide binding]; other site 498214004203 active site 498214004204 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 498214004205 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 498214004206 active site 498214004207 DNA binding site [nucleotide binding] 498214004208 Methyltransferase domain; Region: Methyltransf_26; pfam13659 498214004209 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 498214004210 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 498214004211 Phosphotransferase enzyme family; Region: APH; pfam01636 498214004212 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 498214004213 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 498214004214 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 498214004215 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 498214004216 Walker A/P-loop; other site 498214004217 ATP binding site [chemical binding]; other site 498214004218 Q-loop/lid; other site 498214004219 ABC transporter signature motif; other site 498214004220 Walker B; other site 498214004221 D-loop; other site 498214004222 H-loop/switch region; other site 498214004223 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 498214004224 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 498214004225 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 498214004226 TM-ABC transporter signature motif; other site 498214004227 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 498214004228 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 498214004229 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 498214004230 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 498214004231 ligand binding site [chemical binding]; other site 498214004232 dimerization interface [polypeptide binding]; other site 498214004233 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 498214004234 active site 498214004235 intersubunit interface [polypeptide binding]; other site 498214004236 Zn2+ binding site [ion binding]; other site 498214004237 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 498214004238 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 498214004239 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 498214004240 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 498214004241 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 498214004242 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 498214004243 Predicted membrane protein [Function unknown]; Region: COG2323 498214004244 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 498214004245 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 498214004246 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 498214004247 A short protein domain of unknown function; Region: IDEAL; smart00914 498214004248 PQ loop repeat; Region: PQ-loop; cl17546 498214004249 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 498214004250 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 498214004251 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 498214004252 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 498214004253 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 498214004254 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 498214004255 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 498214004256 catalytic loop [active] 498214004257 iron binding site [ion binding]; other site 498214004258 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 498214004259 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 498214004260 nucleoside/Zn binding site; other site 498214004261 dimer interface [polypeptide binding]; other site 498214004262 catalytic motif [active] 498214004263 DNA topoisomerase III; Provisional; Region: PRK07726 498214004264 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 498214004265 active site 498214004266 putative interdomain interaction site [polypeptide binding]; other site 498214004267 putative metal-binding site [ion binding]; other site 498214004268 putative nucleotide binding site [chemical binding]; other site 498214004269 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 498214004270 domain I; other site 498214004271 DNA binding groove [nucleotide binding] 498214004272 phosphate binding site [ion binding]; other site 498214004273 domain II; other site 498214004274 domain III; other site 498214004275 nucleotide binding site [chemical binding]; other site 498214004276 catalytic site [active] 498214004277 domain IV; other site 498214004278 VanZ like family; Region: VanZ; pfam04892 498214004279 RDD family; Region: RDD; pfam06271 498214004280 Predicted membrane protein [Function unknown]; Region: COG1971 498214004281 Domain of unknown function DUF; Region: DUF204; pfam02659 498214004282 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 498214004283 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 498214004284 active site 498214004285 intersubunit interactions; other site 498214004286 catalytic residue [active] 498214004287 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 498214004288 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498214004289 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 498214004290 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 498214004291 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 498214004292 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 498214004293 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 498214004294 metal binding site [ion binding]; metal-binding site 498214004295 active site 498214004296 I-site; other site 498214004297 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 498214004298 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 498214004299 NodB motif; other site 498214004300 putative active site [active] 498214004301 putative catalytic site [active] 498214004302 putative Zn binding site [ion binding]; other site 498214004303 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 498214004304 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 498214004305 DXD motif; other site 498214004306 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 498214004307 Probable zinc-binding domain; Region: zf-trcl; pfam13451 498214004308 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 498214004309 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 498214004310 putative homodimer interface [polypeptide binding]; other site 498214004311 putative homotetramer interface [polypeptide binding]; other site 498214004312 putative allosteric switch controlling residues; other site 498214004313 putative metal binding site [ion binding]; other site 498214004314 putative homodimer-homodimer interface [polypeptide binding]; other site 498214004315 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 498214004316 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 498214004317 metal-binding site [ion binding] 498214004318 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 498214004319 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 498214004320 metal-binding site [ion binding] 498214004321 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 498214004322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498214004323 motif II; other site 498214004324 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 498214004325 metal-binding site [ion binding] 498214004326 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 498214004327 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 498214004328 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 498214004329 Soluble P-type ATPase [General function prediction only]; Region: COG4087 498214004330 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 498214004331 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 498214004332 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 498214004333 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 498214004334 Walker A/P-loop; other site 498214004335 ATP binding site [chemical binding]; other site 498214004336 Q-loop/lid; other site 498214004337 ABC transporter signature motif; other site 498214004338 Walker B; other site 498214004339 D-loop; other site 498214004340 H-loop/switch region; other site 498214004341 CAAX protease self-immunity; Region: Abi; pfam02517 498214004342 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 498214004343 EDD domain protein, DegV family; Region: DegV; TIGR00762 498214004344 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 498214004345 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 498214004346 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 498214004347 nucleotide binding site/active site [active] 498214004348 HIT family signature motif; other site 498214004349 catalytic residue [active] 498214004350 Membrane protein of unknown function; Region: DUF360; pfam04020 498214004351 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 498214004352 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 498214004353 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 498214004354 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 498214004355 TrkA-N domain; Region: TrkA_N; pfam02254 498214004356 TrkA-C domain; Region: TrkA_C; pfam02080 498214004357 TrkA-N domain; Region: TrkA_N; pfam02254 498214004358 TrkA-C domain; Region: TrkA_C; pfam02080 498214004359 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 498214004360 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 498214004361 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 498214004362 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 498214004363 Part of AAA domain; Region: AAA_19; pfam13245 498214004364 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 498214004365 active site 498214004366 catalytic site [active] 498214004367 substrate binding site [chemical binding]; other site 498214004368 Family description; Region: UvrD_C_2; pfam13538 498214004369 Protein of unknown function DUF116; Region: DUF116; pfam01976 498214004370 Predicted membrane protein [General function prediction only]; Region: COG4194 498214004371 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 498214004372 Predicted transcriptional regulators [Transcription]; Region: COG1725 498214004373 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214004374 DNA-binding site [nucleotide binding]; DNA binding site 498214004375 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498214004376 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498214004377 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 498214004378 Rubrerythrin [Energy production and conversion]; Region: COG1592 498214004379 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 498214004380 binuclear metal center [ion binding]; other site 498214004381 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 498214004382 iron binding site [ion binding]; other site 498214004383 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214004384 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214004385 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214004386 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 498214004387 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 498214004388 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 498214004389 active site turn [active] 498214004390 phosphorylation site [posttranslational modification] 498214004391 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 498214004392 HPr interaction site; other site 498214004393 glycerol kinase (GK) interaction site [polypeptide binding]; other site 498214004394 active site 498214004395 phosphorylation site [posttranslational modification] 498214004396 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 498214004397 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 498214004398 catalytic residue [active] 498214004399 putative FPP diphosphate binding site; other site 498214004400 putative FPP binding hydrophobic cleft; other site 498214004401 dimer interface [polypeptide binding]; other site 498214004402 putative IPP diphosphate binding site; other site 498214004403 Rrf2 family protein; Region: rrf2_super; TIGR00738 498214004404 Transcriptional regulator; Region: Rrf2; pfam02082 498214004405 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 498214004406 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498214004407 ACS interaction site; other site 498214004408 CODH interaction site; other site 498214004409 metal cluster binding site [ion binding]; other site 498214004410 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 498214004411 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 498214004412 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 498214004413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 498214004414 EamA-like transporter family; Region: EamA; pfam00892 498214004415 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 498214004416 EamA-like transporter family; Region: EamA; pfam00892 498214004417 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 498214004418 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 498214004419 ligand binding site [chemical binding]; other site 498214004420 flexible hinge region; other site 498214004421 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 498214004422 putative switch regulator; other site 498214004423 non-specific DNA interactions [nucleotide binding]; other site 498214004424 DNA binding site [nucleotide binding] 498214004425 sequence specific DNA binding site [nucleotide binding]; other site 498214004426 putative cAMP binding site [chemical binding]; other site 498214004427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498214004428 Major Facilitator Superfamily; Region: MFS_1; pfam07690 498214004429 putative substrate translocation pore; other site 498214004430 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 498214004431 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 498214004432 putative binding site residues; other site 498214004433 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 498214004434 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 498214004435 ABC-ATPase subunit interface; other site 498214004436 dimer interface [polypeptide binding]; other site 498214004437 putative PBP binding regions; other site 498214004438 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 498214004439 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 498214004440 Walker A/P-loop; other site 498214004441 ATP binding site [chemical binding]; other site 498214004442 Q-loop/lid; other site 498214004443 ABC transporter signature motif; other site 498214004444 Walker B; other site 498214004445 D-loop; other site 498214004446 H-loop/switch region; other site 498214004447 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 498214004448 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 498214004449 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 498214004450 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 498214004451 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 498214004452 putative active site [active] 498214004453 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 498214004454 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 498214004455 putative active site [active] 498214004456 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 498214004457 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 498214004458 active site turn [active] 498214004459 phosphorylation site [posttranslational modification] 498214004460 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 498214004461 Uncharacterized conserved protein [Function unknown]; Region: COG3589 498214004462 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 498214004463 Helix-turn-helix domain; Region: HTH_18; pfam12833 498214004464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 498214004465 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 498214004466 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 498214004467 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 498214004468 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 498214004469 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 498214004470 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 498214004471 HAMP domain; Region: HAMP; pfam00672 498214004472 dimerization interface [polypeptide binding]; other site 498214004473 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214004474 dimer interface [polypeptide binding]; other site 498214004475 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 498214004476 putative CheW interface [polypeptide binding]; other site 498214004477 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 498214004478 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 498214004479 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 498214004480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214004481 dimer interface [polypeptide binding]; other site 498214004482 conserved gate region; other site 498214004483 putative PBP binding loops; other site 498214004484 ABC-ATPase subunit interface; other site 498214004485 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 498214004486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214004487 dimer interface [polypeptide binding]; other site 498214004488 conserved gate region; other site 498214004489 putative PBP binding loops; other site 498214004490 ABC-ATPase subunit interface; other site 498214004491 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 498214004492 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 498214004493 Walker A/P-loop; other site 498214004494 ATP binding site [chemical binding]; other site 498214004495 Q-loop/lid; other site 498214004496 ABC transporter signature motif; other site 498214004497 Walker B; other site 498214004498 D-loop; other site 498214004499 H-loop/switch region; other site 498214004500 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 498214004501 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 498214004502 Walker A/P-loop; other site 498214004503 ATP binding site [chemical binding]; other site 498214004504 Q-loop/lid; other site 498214004505 ABC transporter signature motif; other site 498214004506 Walker B; other site 498214004507 D-loop; other site 498214004508 H-loop/switch region; other site 498214004509 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 498214004510 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 498214004511 ABC-ATPase subunit interface; other site 498214004512 dimer interface [polypeptide binding]; other site 498214004513 putative PBP binding regions; other site 498214004514 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 498214004515 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 498214004516 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 498214004517 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 498214004518 metal binding site [ion binding]; metal-binding site 498214004519 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 498214004520 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498214004521 nucleotide binding region [chemical binding]; other site 498214004522 ATP-binding site [chemical binding]; other site 498214004523 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 498214004524 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 498214004525 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 498214004526 metal binding site [ion binding]; metal-binding site 498214004527 active site 498214004528 I-site; other site 498214004529 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 498214004530 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 498214004531 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 498214004532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214004533 dimer interface [polypeptide binding]; other site 498214004534 conserved gate region; other site 498214004535 putative PBP binding loops; other site 498214004536 ABC-ATPase subunit interface; other site 498214004537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214004538 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 498214004539 Walker A/P-loop; other site 498214004540 ATP binding site [chemical binding]; other site 498214004541 Q-loop/lid; other site 498214004542 ABC transporter signature motif; other site 498214004543 Walker B; other site 498214004544 D-loop; other site 498214004545 H-loop/switch region; other site 498214004546 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 498214004547 putative DNA binding helix; other site 498214004548 metal binding site 2 [ion binding]; metal-binding site 498214004549 metal binding site 1 [ion binding]; metal-binding site 498214004550 dimer interface [polypeptide binding]; other site 498214004551 structural Zn2+ binding site [ion binding]; other site 498214004552 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 498214004553 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 498214004554 DNA binding residues [nucleotide binding] 498214004555 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 498214004556 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498214004557 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 498214004558 putative active site [active] 498214004559 Zn binding site [ion binding]; other site 498214004560 ribonuclease Z; Region: RNase_Z; TIGR02651 498214004561 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 498214004562 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 498214004563 pentamer interface [polypeptide binding]; other site 498214004564 dodecaamer interface [polypeptide binding]; other site 498214004565 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 498214004566 Histidine kinase; Region: HisKA_3; pfam07730 498214004567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214004568 ATP binding site [chemical binding]; other site 498214004569 Mg2+ binding site [ion binding]; other site 498214004570 G-X-G motif; other site 498214004571 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 498214004572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214004573 active site 498214004574 phosphorylation site [posttranslational modification] 498214004575 intermolecular recognition site; other site 498214004576 dimerization interface [polypeptide binding]; other site 498214004577 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 498214004578 DNA binding residues [nucleotide binding] 498214004579 dimerization interface [polypeptide binding]; other site 498214004580 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 498214004581 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214004582 Walker A/P-loop; other site 498214004583 ATP binding site [chemical binding]; other site 498214004584 Q-loop/lid; other site 498214004585 ABC transporter signature motif; other site 498214004586 Walker B; other site 498214004587 D-loop; other site 498214004588 H-loop/switch region; other site 498214004589 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 498214004590 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 498214004591 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 498214004592 FMN binding site [chemical binding]; other site 498214004593 dimer interface [polypeptide binding]; other site 498214004594 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 498214004595 DNA-binding site [nucleotide binding]; DNA binding site 498214004596 RNA-binding motif; other site 498214004597 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 498214004598 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 498214004599 metal binding site [ion binding]; metal-binding site 498214004600 dimer interface [polypeptide binding]; other site 498214004601 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 498214004602 TPR repeat; Region: TPR_11; pfam13414 498214004603 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 498214004604 dimer interface [polypeptide binding]; other site 498214004605 pyridoxal binding site [chemical binding]; other site 498214004606 ATP binding site [chemical binding]; other site 498214004607 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 498214004608 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214004609 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498214004610 Walker A/P-loop; other site 498214004611 ATP binding site [chemical binding]; other site 498214004612 Q-loop/lid; other site 498214004613 ABC transporter signature motif; other site 498214004614 Walker B; other site 498214004615 D-loop; other site 498214004616 H-loop/switch region; other site 498214004617 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 498214004618 FtsX-like permease family; Region: FtsX; pfam02687 498214004619 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214004620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214004621 active site 498214004622 phosphorylation site [posttranslational modification] 498214004623 intermolecular recognition site; other site 498214004624 dimerization interface [polypeptide binding]; other site 498214004625 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214004626 DNA binding site [nucleotide binding] 498214004627 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214004628 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 498214004629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214004630 ATP binding site [chemical binding]; other site 498214004631 Mg2+ binding site [ion binding]; other site 498214004632 G-X-G motif; other site 498214004633 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214004634 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498214004635 Walker A/P-loop; other site 498214004636 ATP binding site [chemical binding]; other site 498214004637 Q-loop/lid; other site 498214004638 ABC transporter signature motif; other site 498214004639 Walker B; other site 498214004640 D-loop; other site 498214004641 H-loop/switch region; other site 498214004642 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 498214004643 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 498214004644 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 498214004645 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 498214004646 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498214004647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214004648 homodimer interface [polypeptide binding]; other site 498214004649 catalytic residue [active] 498214004650 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 498214004651 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 498214004652 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 498214004653 substrate binding pocket [chemical binding]; other site 498214004654 membrane-bound complex binding site; other site 498214004655 hinge residues; other site 498214004656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214004657 dimer interface [polypeptide binding]; other site 498214004658 conserved gate region; other site 498214004659 putative PBP binding loops; other site 498214004660 ABC-ATPase subunit interface; other site 498214004661 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 498214004662 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 498214004663 Walker A/P-loop; other site 498214004664 ATP binding site [chemical binding]; other site 498214004665 Q-loop/lid; other site 498214004666 ABC transporter signature motif; other site 498214004667 Walker B; other site 498214004668 D-loop; other site 498214004669 H-loop/switch region; other site 498214004670 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214004671 non-specific DNA binding site [nucleotide binding]; other site 498214004672 salt bridge; other site 498214004673 sequence-specific DNA binding site [nucleotide binding]; other site 498214004674 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 498214004675 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 498214004676 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 498214004677 putative active site [active] 498214004678 putative CoA binding site [chemical binding]; other site 498214004679 nudix motif; other site 498214004680 metal binding site [ion binding]; metal-binding site 498214004681 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 498214004682 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 498214004683 dimer interface [polypeptide binding]; other site 498214004684 active site 498214004685 metal binding site [ion binding]; metal-binding site 498214004686 Predicted membrane protein [Function unknown]; Region: COG1288 498214004687 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 498214004688 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 498214004689 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 498214004690 active site 498214004691 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 498214004692 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 498214004693 substrate binding pocket [chemical binding]; other site 498214004694 membrane-bound complex binding site; other site 498214004695 hinge residues; other site 498214004696 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 498214004697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214004698 dimer interface [polypeptide binding]; other site 498214004699 conserved gate region; other site 498214004700 putative PBP binding loops; other site 498214004701 ABC-ATPase subunit interface; other site 498214004702 Protein of unknown function (DUF523); Region: DUF523; cl00733 498214004703 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 498214004704 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498214004705 ATP binding site [chemical binding]; other site 498214004706 Family description; Region: UvrD_C_2; pfam13538 498214004707 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 498214004708 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 498214004709 active site 498214004710 catalytic residues [active] 498214004711 DNA binding site [nucleotide binding] 498214004712 Int/Topo IB signature motif; other site 498214004713 Divergent AAA domain; Region: AAA_4; pfam04326 498214004714 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 498214004715 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 498214004716 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 498214004717 active site 498214004718 Int/Topo IB signature motif; other site 498214004719 catalytic residues [active] 498214004720 DNA binding site [nucleotide binding] 498214004721 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 498214004722 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 498214004723 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214004724 non-specific DNA binding site [nucleotide binding]; other site 498214004725 salt bridge; other site 498214004726 sequence-specific DNA binding site [nucleotide binding]; other site 498214004727 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 498214004728 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 498214004729 GIY-YIG motif/motif A; other site 498214004730 putative active site [active] 498214004731 catalytic site [active] 498214004732 putative metal binding site [ion binding]; other site 498214004733 Phage terminase, small subunit; Region: Terminase_4; cl01525 498214004734 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 498214004735 Phage portal protein; Region: Phage_portal; pfam04860 498214004736 Phage-related protein [Function unknown]; Region: COG4695 498214004737 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 498214004738 oligomer interface [polypeptide binding]; other site 498214004739 active site residues [active] 498214004740 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 498214004741 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 498214004742 Phage capsid family; Region: Phage_capsid; pfam05065 498214004743 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 498214004744 oligomerization interface [polypeptide binding]; other site 498214004745 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 498214004746 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 498214004747 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 498214004748 Phage tail protein; Region: Sipho_tail; cl17486 498214004749 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 498214004750 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 498214004751 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 498214004752 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 498214004753 active site 498214004754 metal binding site [ion binding]; metal-binding site 498214004755 Bacterial SH3 domain; Region: SH3_3; pfam08239 498214004756 cell division protein FtsA; Region: ftsA; TIGR01174 498214004757 Cell division protein FtsA; Region: FtsA; smart00842 498214004758 Cell division protein FtsA; Region: FtsA; pfam14450 498214004759 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 498214004760 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 498214004761 metal binding site [ion binding]; metal-binding site 498214004762 dimer interface [polypeptide binding]; other site 498214004763 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 498214004764 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 498214004765 active site 498214004766 metal binding site [ion binding]; metal-binding site 498214004767 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 498214004768 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 498214004769 RNA binding surface [nucleotide binding]; other site 498214004770 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 498214004771 active site 498214004772 stage V sporulation protein B; Region: spore_V_B; TIGR02900 498214004773 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 498214004774 stage V sporulation protein B; Region: spore_V_B; TIGR02900 498214004775 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 498214004776 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 498214004777 diiron binding motif [ion binding]; other site 498214004778 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 498214004779 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 498214004780 putative active site [active] 498214004781 metal binding site [ion binding]; metal-binding site 498214004782 AAA domain; Region: AAA_32; pfam13654 498214004783 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 498214004784 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 498214004785 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 498214004786 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 498214004787 active site 498214004788 Zn binding site [ion binding]; other site 498214004789 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 498214004790 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 498214004791 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 498214004792 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 498214004793 active site 498214004794 Zn binding site [ion binding]; other site 498214004795 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 498214004796 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 498214004797 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 498214004798 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 498214004799 active site 498214004800 Zn binding site [ion binding]; other site 498214004801 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 498214004802 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 498214004803 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 498214004804 active site 498214004805 Zn binding site [ion binding]; other site 498214004806 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 498214004807 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 498214004808 active site 498214004809 Zn binding site [ion binding]; other site 498214004810 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 498214004811 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 498214004812 dimerization interface [polypeptide binding]; other site 498214004813 active site 498214004814 L-aspartate oxidase; Provisional; Region: PRK06175 498214004815 FAD binding domain; Region: FAD_binding_2; pfam00890 498214004816 Quinolinate synthetase A protein; Region: NadA; pfam02445 498214004817 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 498214004818 metal binding site [ion binding]; metal-binding site 498214004819 Haemolysin-III related; Region: HlyIII; cl03831 498214004820 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 498214004821 GTP-binding protein YchF; Reviewed; Region: PRK09601 498214004822 YchF GTPase; Region: YchF; cd01900 498214004823 G1 box; other site 498214004824 GTP/Mg2+ binding site [chemical binding]; other site 498214004825 Switch I region; other site 498214004826 G2 box; other site 498214004827 Switch II region; other site 498214004828 G3 box; other site 498214004829 G4 box; other site 498214004830 G5 box; other site 498214004831 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 498214004832 cell division protein MraZ; Reviewed; Region: PRK00326 498214004833 MraZ protein; Region: MraZ; pfam02381 498214004834 MraZ protein; Region: MraZ; pfam02381 498214004835 MraW methylase family; Region: Methyltransf_5; pfam01795 498214004836 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 498214004837 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 498214004838 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 498214004839 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 498214004840 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 498214004841 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 498214004842 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 498214004843 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 498214004844 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 498214004845 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 498214004846 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 498214004847 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 498214004848 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 498214004849 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 498214004850 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 498214004851 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 498214004852 Mg++ binding site [ion binding]; other site 498214004853 putative catalytic motif [active] 498214004854 putative substrate binding site [chemical binding]; other site 498214004855 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 498214004856 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 498214004857 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 498214004858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 498214004859 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 498214004860 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 498214004861 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 498214004862 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 498214004863 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 498214004864 catalytic residue [active] 498214004865 Protein of unknown function (DUF552); Region: DUF552; cl00775 498214004866 YGGT family; Region: YGGT; pfam02325 498214004867 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 498214004868 DivIVA protein; Region: DivIVA; pfam05103 498214004869 DivIVA domain; Region: DivI1A_domain; TIGR03544 498214004870 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 498214004871 active site 498214004872 dimer interface [polypeptide binding]; other site 498214004873 metal binding site [ion binding]; metal-binding site 498214004874 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 498214004875 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 498214004876 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13398 498214004877 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 498214004878 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 498214004879 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 498214004880 hinge; other site 498214004881 active site 498214004882 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 498214004883 lipoprotein signal peptidase; Provisional; Region: PRK14791 498214004884 lipoprotein signal peptidase; Provisional; Region: PRK14787 498214004885 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 498214004886 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 498214004887 RNA binding surface [nucleotide binding]; other site 498214004888 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 498214004889 active site 498214004890 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 498214004891 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498214004892 active site 498214004893 uracil transporter; Provisional; Region: PRK10720 498214004894 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 498214004895 active site 498214004896 putative catalytic site [active] 498214004897 phosphate binding site A [ion binding]; other site 498214004898 DNA binding site [nucleotide binding] 498214004899 metal binding site A [ion binding]; metal-binding site 498214004900 putative AP binding site [nucleotide binding]; other site 498214004901 putative metal binding site B [ion binding]; other site 498214004902 phosphate binding site B [ion binding]; other site 498214004903 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 498214004904 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 498214004905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 498214004906 Carbonic anhydrase; Region: Pro_CA; smart00947 498214004907 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 498214004908 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 498214004909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214004910 dimer interface [polypeptide binding]; other site 498214004911 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 498214004912 conserved gate region; other site 498214004913 putative PBP binding loops; other site 498214004914 ABC-ATPase subunit interface; other site 498214004915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214004916 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214004917 Walker A/P-loop; other site 498214004918 ATP binding site [chemical binding]; other site 498214004919 Q-loop/lid; other site 498214004920 ABC transporter signature motif; other site 498214004921 Walker B; other site 498214004922 D-loop; other site 498214004923 H-loop/switch region; other site 498214004924 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 498214004925 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 498214004926 active site 498214004927 nucleophile elbow; other site 498214004928 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 498214004929 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 498214004930 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 498214004931 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 498214004932 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 498214004933 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498214004934 Uroporphyrinogen decarboxylase (URO-D); Region: URO-D; pfam01208 498214004935 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 498214004936 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 498214004937 B12 binding site [chemical binding]; other site 498214004938 cobalt ligand [ion binding]; other site 498214004939 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 498214004940 MtaA_CmuA_like family. MtaA/CmuA, also MtsA, or methyltransferase 2 (MT2) MT2-A and MT2-M isozymes, are methylcobamide:Coenzyme M methyltransferases, which play a role in metabolic pathways of methane formation from various substrates, such as methylated...; Region: Mta_CmuA_like; cd03307 498214004941 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 498214004942 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 498214004943 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 498214004944 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 498214004945 Walker A/P-loop; other site 498214004946 ATP binding site [chemical binding]; other site 498214004947 Q-loop/lid; other site 498214004948 ABC transporter signature motif; other site 498214004949 Walker B; other site 498214004950 D-loop; other site 498214004951 H-loop/switch region; other site 498214004952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214004953 dimer interface [polypeptide binding]; other site 498214004954 conserved gate region; other site 498214004955 ABC-ATPase subunit interface; other site 498214004956 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 498214004957 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 498214004958 MORN repeat; Region: MORN; cl14787 498214004959 MORN repeat; Region: MORN; cl14787 498214004960 MORN repeat; Region: MORN; cl14787 498214004961 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 498214004962 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 498214004963 active site 498214004964 FMN binding site [chemical binding]; other site 498214004965 substrate binding site [chemical binding]; other site 498214004966 putative catalytic residue [active] 498214004967 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 498214004968 dimer interface [polypeptide binding]; other site 498214004969 active site 498214004970 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 498214004971 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 498214004972 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 498214004973 [2Fe-2S] cluster binding site [ion binding]; other site 498214004974 DNA topoisomerase III; Provisional; Region: PRK07726 498214004975 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 498214004976 active site 498214004977 putative interdomain interaction site [polypeptide binding]; other site 498214004978 putative metal-binding site [ion binding]; other site 498214004979 putative nucleotide binding site [chemical binding]; other site 498214004980 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 498214004981 domain I; other site 498214004982 DNA binding groove [nucleotide binding] 498214004983 phosphate binding site [ion binding]; other site 498214004984 domain II; other site 498214004985 domain III; other site 498214004986 nucleotide binding site [chemical binding]; other site 498214004987 catalytic site [active] 498214004988 domain IV; other site 498214004989 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 498214004990 Walker A/P-loop; other site 498214004991 ATP binding site [chemical binding]; other site 498214004992 Q-loop/lid; other site 498214004993 ABC transporter signature motif; other site 498214004994 Walker B; other site 498214004995 D-loop; other site 498214004996 H-loop/switch region; other site 498214004997 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 498214004998 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 498214004999 active site 498214005000 catalytic tetrad [active] 498214005001 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498214005002 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 498214005003 putative deacylase active site [active] 498214005004 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214005005 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498214005006 Walker A/P-loop; other site 498214005007 ATP binding site [chemical binding]; other site 498214005008 Q-loop/lid; other site 498214005009 ABC transporter signature motif; other site 498214005010 Walker B; other site 498214005011 D-loop; other site 498214005012 H-loop/switch region; other site 498214005013 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 498214005014 FtsX-like permease family; Region: FtsX; pfam02687 498214005015 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498214005016 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498214005017 Protein of unknown function (DUF523); Region: DUF523; pfam04463 498214005018 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 498214005019 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 498214005020 Walker A/P-loop; other site 498214005021 ATP binding site [chemical binding]; other site 498214005022 Q-loop/lid; other site 498214005023 ABC transporter signature motif; other site 498214005024 Walker B; other site 498214005025 D-loop; other site 498214005026 H-loop/switch region; other site 498214005027 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 498214005028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214005029 dimer interface [polypeptide binding]; other site 498214005030 conserved gate region; other site 498214005031 putative PBP binding loops; other site 498214005032 ABC-ATPase subunit interface; other site 498214005033 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 498214005034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214005035 dimer interface [polypeptide binding]; other site 498214005036 conserved gate region; other site 498214005037 putative PBP binding loops; other site 498214005038 ABC-ATPase subunit interface; other site 498214005039 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 498214005040 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 498214005041 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 498214005042 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 498214005043 NAD binding site [chemical binding]; other site 498214005044 dimer interface [polypeptide binding]; other site 498214005045 substrate binding site [chemical binding]; other site 498214005046 tetramer (dimer of dimers) interface [polypeptide binding]; other site 498214005047 Transcriptional regulators [Transcription]; Region: FadR; COG2186 498214005048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214005049 DNA-binding site [nucleotide binding]; DNA binding site 498214005050 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 498214005051 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 498214005052 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 498214005053 gating phenylalanine in ion channel; other site 498214005054 PAS domain S-box; Region: sensory_box; TIGR00229 498214005055 PAS domain; Region: PAS; smart00091 498214005056 putative active site [active] 498214005057 heme pocket [chemical binding]; other site 498214005058 PAS domain S-box; Region: sensory_box; TIGR00229 498214005059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498214005060 putative active site [active] 498214005061 heme pocket [chemical binding]; other site 498214005062 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 498214005063 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 498214005064 metal binding site [ion binding]; metal-binding site 498214005065 active site 498214005066 I-site; other site 498214005067 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 498214005068 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214005069 Zn2+ binding site [ion binding]; other site 498214005070 Mg2+ binding site [ion binding]; other site 498214005071 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 498214005072 dimerization interface [polypeptide binding]; other site 498214005073 Cache domain; Region: Cache_1; pfam02743 498214005074 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214005075 dimerization interface [polypeptide binding]; other site 498214005076 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498214005077 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214005078 dimer interface [polypeptide binding]; other site 498214005079 putative CheW interface [polypeptide binding]; other site 498214005080 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 498214005081 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 498214005082 putative active site [active] 498214005083 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 498214005084 Interdomain contacts; other site 498214005085 Cytokine receptor motif; other site 498214005086 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 498214005087 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 498214005088 Predicted transcriptional regulators [Transcription]; Region: COG1733 498214005089 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 498214005090 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 498214005091 FMN binding site [chemical binding]; other site 498214005092 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 498214005093 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 498214005094 active site 498214005095 metal binding site [ion binding]; metal-binding site 498214005096 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 498214005097 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 498214005098 DNA binding site [nucleotide binding] 498214005099 active site 498214005100 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 498214005101 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214005102 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214005103 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214005104 hypothetical protein; Provisional; Region: PRK02399 498214005105 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 498214005106 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 498214005107 Cupin domain; Region: Cupin_2; cl17218 498214005108 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 498214005109 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214005110 non-specific DNA binding site [nucleotide binding]; other site 498214005111 salt bridge; other site 498214005112 sequence-specific DNA binding site [nucleotide binding]; other site 498214005113 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 498214005114 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 498214005115 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 498214005116 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 498214005117 Soluble P-type ATPase [General function prediction only]; Region: COG4087 498214005118 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 498214005119 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 498214005120 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 498214005121 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 498214005122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498214005123 putative substrate translocation pore; other site 498214005124 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 498214005125 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 498214005126 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 498214005127 HDOD domain; Region: HDOD; pfam08668 498214005128 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214005129 Zn2+ binding site [ion binding]; other site 498214005130 Mg2+ binding site [ion binding]; other site 498214005131 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 498214005132 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 498214005133 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 498214005134 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 498214005135 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 498214005136 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 498214005137 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 498214005138 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 498214005139 active site 498214005140 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 498214005141 Chloramphenicol acetyltransferase; Region: CAT; smart01059 498214005142 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 498214005143 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 498214005144 ligand binding site [chemical binding]; other site 498214005145 flexible hinge region; other site 498214005146 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 498214005147 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 498214005148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 498214005149 Predicted transcriptional regulator [Transcription]; Region: COG2378 498214005150 HTH domain; Region: HTH_11; pfam08279 498214005151 WYL domain; Region: WYL; pfam13280 498214005152 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 498214005153 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 498214005154 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 498214005155 active site 498214005156 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 498214005157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214005158 FeS/SAM binding site; other site 498214005159 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 498214005160 active site 498214005161 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 498214005162 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 498214005163 Ligand Binding Site [chemical binding]; other site 498214005164 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498214005165 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214005166 dimer interface [polypeptide binding]; other site 498214005167 putative CheW interface [polypeptide binding]; other site 498214005168 Protein of unknown function (DUF975); Region: DUF975; cl10504 498214005169 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 498214005170 intersubunit interface [polypeptide binding]; other site 498214005171 active site 498214005172 catalytic residue [active] 498214005173 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 498214005174 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 498214005175 substrate binding site [chemical binding]; other site 498214005176 dimer interface [polypeptide binding]; other site 498214005177 ATP binding site [chemical binding]; other site 498214005178 Predicted membrane protein [Function unknown]; Region: COG2323 498214005179 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 498214005180 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 498214005181 CPxP motif; other site 498214005182 putative inner membrane protein; Provisional; Region: PRK11099 498214005183 Transcriptional regulator [Transcription]; Region: LysR; COG0583 498214005184 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 498214005185 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 498214005186 dimerization interface [polypeptide binding]; other site 498214005187 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 498214005188 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 498214005189 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 498214005190 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 498214005191 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 498214005192 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 498214005193 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 498214005194 active site residue [active] 498214005195 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 498214005196 Sulphur transport; Region: Sulf_transp; pfam04143 498214005197 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 498214005198 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 498214005199 Walker A/P-loop; other site 498214005200 ATP binding site [chemical binding]; other site 498214005201 Q-loop/lid; other site 498214005202 ABC transporter signature motif; other site 498214005203 Walker B; other site 498214005204 D-loop; other site 498214005205 H-loop/switch region; other site 498214005206 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 498214005207 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 498214005208 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 498214005209 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 498214005210 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214005211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214005212 active site 498214005213 phosphorylation site [posttranslational modification] 498214005214 intermolecular recognition site; other site 498214005215 dimerization interface [polypeptide binding]; other site 498214005216 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214005217 DNA binding site [nucleotide binding] 498214005218 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214005219 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 498214005220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214005221 dimer interface [polypeptide binding]; other site 498214005222 phosphorylation site [posttranslational modification] 498214005223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214005224 ATP binding site [chemical binding]; other site 498214005225 Mg2+ binding site [ion binding]; other site 498214005226 G-X-G motif; other site 498214005227 arginine deiminase; Provisional; Region: PRK01388 498214005228 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 498214005229 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 498214005230 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 498214005231 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 498214005232 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 498214005233 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 498214005234 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 498214005235 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498214005236 ATP binding site [chemical binding]; other site 498214005237 putative Mg++ binding site [ion binding]; other site 498214005238 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498214005239 nucleotide binding region [chemical binding]; other site 498214005240 ATP-binding site [chemical binding]; other site 498214005241 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 498214005242 synthetase active site [active] 498214005243 NTP binding site [chemical binding]; other site 498214005244 metal binding site [ion binding]; metal-binding site 498214005245 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 498214005246 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214005247 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214005248 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 498214005249 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 498214005250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214005251 Walker A/P-loop; other site 498214005252 ATP binding site [chemical binding]; other site 498214005253 Q-loop/lid; other site 498214005254 ABC transporter signature motif; other site 498214005255 Walker B; other site 498214005256 D-loop; other site 498214005257 H-loop/switch region; other site 498214005258 Transcriptional regulators [Transcription]; Region: PurR; COG1609 498214005259 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 498214005260 DNA binding site [nucleotide binding] 498214005261 domain linker motif; other site 498214005262 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 498214005263 putative dimerization interface [polypeptide binding]; other site 498214005264 putative ligand binding site [chemical binding]; other site 498214005265 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 498214005266 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 498214005267 nucleotide binding site [chemical binding]; other site 498214005268 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 498214005269 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 498214005270 Ca binding site [ion binding]; other site 498214005271 active site 498214005272 catalytic site [active] 498214005273 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 498214005274 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 498214005275 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 498214005276 active site turn [active] 498214005277 phosphorylation site [posttranslational modification] 498214005278 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 498214005279 putative catalytic site [active] 498214005280 putative metal binding site [ion binding]; other site 498214005281 putative phosphate binding site [ion binding]; other site 498214005282 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 498214005283 Domain of unknown function DUF; Region: DUF204; pfam02659 498214005284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 498214005285 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 498214005286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214005287 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 498214005288 dimerization interface [polypeptide binding]; other site 498214005289 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214005290 dimer interface [polypeptide binding]; other site 498214005291 phosphorylation site [posttranslational modification] 498214005292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214005293 ATP binding site [chemical binding]; other site 498214005294 Mg2+ binding site [ion binding]; other site 498214005295 G-X-G motif; other site 498214005296 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214005297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214005298 active site 498214005299 phosphorylation site [posttranslational modification] 498214005300 intermolecular recognition site; other site 498214005301 dimerization interface [polypeptide binding]; other site 498214005302 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214005303 DNA binding site [nucleotide binding] 498214005304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498214005305 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 498214005306 putative substrate translocation pore; other site 498214005307 Protein of unknown function (DUF441); Region: DUF441; cl01041 498214005308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498214005309 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 498214005310 active site 498214005311 motif I; other site 498214005312 motif II; other site 498214005313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498214005314 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 498214005315 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 498214005316 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 498214005317 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 498214005318 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498214005319 DNA binding residues [nucleotide binding] 498214005320 YvrJ protein family; Region: YvrJ; pfam12841 498214005321 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 498214005322 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 498214005323 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 498214005324 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 498214005325 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 498214005326 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 498214005327 FAD binding site [chemical binding]; other site 498214005328 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 498214005329 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 498214005330 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 498214005331 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 498214005332 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 498214005333 substrate binding pocket [chemical binding]; other site 498214005334 dimer interface [polypeptide binding]; other site 498214005335 inhibitor binding site; inhibition site 498214005336 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 498214005337 B12 binding site [chemical binding]; other site 498214005338 cobalt ligand [ion binding]; other site 498214005339 RNA polymerase factor sigma-70; Validated; Region: PRK06811 498214005340 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 498214005341 DNA binding residues [nucleotide binding] 498214005342 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 498214005343 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 498214005344 GAF domain; Region: GAF; pfam01590 498214005345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214005346 Walker A motif; other site 498214005347 ATP binding site [chemical binding]; other site 498214005348 Walker B motif; other site 498214005349 arginine finger; other site 498214005350 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 498214005351 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 498214005352 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 498214005353 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 498214005354 tetramer interface [polypeptide binding]; other site 498214005355 TPP-binding site [chemical binding]; other site 498214005356 heterodimer interface [polypeptide binding]; other site 498214005357 phosphorylation loop region [posttranslational modification] 498214005358 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 498214005359 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 498214005360 alpha subunit interface [polypeptide binding]; other site 498214005361 TPP binding site [chemical binding]; other site 498214005362 heterodimer interface [polypeptide binding]; other site 498214005363 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 498214005364 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 498214005365 ATP-NAD kinase; Region: NAD_kinase; pfam01513 498214005366 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 498214005367 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 498214005368 E3 interaction surface; other site 498214005369 lipoyl attachment site [posttranslational modification]; other site 498214005370 e3 binding domain; Region: E3_binding; pfam02817 498214005371 e3 binding domain; Region: E3_binding; pfam02817 498214005372 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 498214005373 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 498214005374 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 498214005375 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 498214005376 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 498214005377 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 498214005378 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 498214005379 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 498214005380 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 498214005381 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 498214005382 Walker A/P-loop; other site 498214005383 ATP binding site [chemical binding]; other site 498214005384 Q-loop/lid; other site 498214005385 ABC transporter signature motif; other site 498214005386 Walker B; other site 498214005387 D-loop; other site 498214005388 H-loop/switch region; other site 498214005389 FOG: CBS domain [General function prediction only]; Region: COG0517 498214005390 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 498214005391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214005392 dimer interface [polypeptide binding]; other site 498214005393 conserved gate region; other site 498214005394 putative PBP binding loops; other site 498214005395 ABC-ATPase subunit interface; other site 498214005396 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 498214005397 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 498214005398 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 498214005399 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 498214005400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214005401 catalytic residue [active] 498214005402 homoserine kinase; Provisional; Region: PRK01212 498214005403 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 498214005404 aspartate kinase; Reviewed; Region: PRK09034 498214005405 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 498214005406 nucleotide binding site [chemical binding]; other site 498214005407 substrate binding site [chemical binding]; other site 498214005408 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 498214005409 allosteric regulatory residue; other site 498214005410 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 498214005411 homoserine dehydrogenase; Provisional; Region: PRK06349 498214005412 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 498214005413 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 498214005414 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 498214005415 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 498214005416 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498214005417 putative active site [active] 498214005418 heme pocket [chemical binding]; other site 498214005419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214005420 Walker A motif; other site 498214005421 ATP binding site [chemical binding]; other site 498214005422 Walker B motif; other site 498214005423 arginine finger; other site 498214005424 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 498214005425 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 498214005426 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 498214005427 putative active site [active] 498214005428 metal binding site [ion binding]; metal-binding site 498214005429 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 498214005430 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 498214005431 FAD binding pocket [chemical binding]; other site 498214005432 FAD binding motif [chemical binding]; other site 498214005433 phosphate binding motif [ion binding]; other site 498214005434 beta-alpha-beta structure motif; other site 498214005435 NAD binding pocket [chemical binding]; other site 498214005436 Iron coordination center [ion binding]; other site 498214005437 putative oxidoreductase; Provisional; Region: PRK12831 498214005438 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 498214005439 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 498214005440 PAS domain; Region: PAS; smart00091 498214005441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214005442 Walker A motif; other site 498214005443 ATP binding site [chemical binding]; other site 498214005444 Walker B motif; other site 498214005445 arginine finger; other site 498214005446 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 498214005447 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 498214005448 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 498214005449 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 498214005450 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 498214005451 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 498214005452 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 498214005453 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 498214005454 Hemerythrin-like domain; Region: Hr-like; cd12108 498214005455 Fe binding site [ion binding]; other site 498214005456 alanine racemase; Reviewed; Region: alr; PRK00053 498214005457 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 498214005458 active site 498214005459 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 498214005460 dimer interface [polypeptide binding]; other site 498214005461 substrate binding site [chemical binding]; other site 498214005462 catalytic residues [active] 498214005463 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498214005464 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214005465 dimer interface [polypeptide binding]; other site 498214005466 putative CheW interface [polypeptide binding]; other site 498214005467 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 498214005468 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 498214005469 Protein of unknown function (DUF975); Region: DUF975; cl10504 498214005470 short chain dehydrogenase; Provisional; Region: PRK06701 498214005471 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 498214005472 NAD binding site [chemical binding]; other site 498214005473 metal binding site [ion binding]; metal-binding site 498214005474 active site 498214005475 Cache domain; Region: Cache_1; pfam02743 498214005476 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498214005477 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214005478 dimer interface [polypeptide binding]; other site 498214005479 putative CheW interface [polypeptide binding]; other site 498214005480 KWG Leptospira; Region: KWG; pfam07656 498214005481 KWG Leptospira; Region: KWG; pfam07656 498214005482 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 498214005483 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 498214005484 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498214005485 ATP binding site [chemical binding]; other site 498214005486 putative Mg++ binding site [ion binding]; other site 498214005487 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498214005488 nucleotide binding region [chemical binding]; other site 498214005489 ATP-binding site [chemical binding]; other site 498214005490 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 498214005491 homodimer interaction site [polypeptide binding]; other site 498214005492 cofactor binding site; other site 498214005493 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 498214005494 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 498214005495 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 498214005496 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 498214005497 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_21; cd08520 498214005498 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 498214005499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214005500 dimer interface [polypeptide binding]; other site 498214005501 conserved gate region; other site 498214005502 putative PBP binding loops; other site 498214005503 ABC-ATPase subunit interface; other site 498214005504 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 498214005505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214005506 dimer interface [polypeptide binding]; other site 498214005507 conserved gate region; other site 498214005508 putative PBP binding loops; other site 498214005509 ABC-ATPase subunit interface; other site 498214005510 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 498214005511 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 498214005512 Walker A/P-loop; other site 498214005513 ATP binding site [chemical binding]; other site 498214005514 Q-loop/lid; other site 498214005515 ABC transporter signature motif; other site 498214005516 Walker B; other site 498214005517 D-loop; other site 498214005518 H-loop/switch region; other site 498214005519 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 498214005520 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 498214005521 Walker A/P-loop; other site 498214005522 ATP binding site [chemical binding]; other site 498214005523 Q-loop/lid; other site 498214005524 ABC transporter signature motif; other site 498214005525 Walker B; other site 498214005526 D-loop; other site 498214005527 H-loop/switch region; other site 498214005528 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 498214005529 active site 498214005530 catalytic site [active] 498214005531 substrate binding site [chemical binding]; other site 498214005532 Predicted secreted protein [Function unknown]; Region: COG4086 498214005533 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 498214005534 Methyltransferase domain; Region: Methyltransf_31; pfam13847 498214005535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214005536 S-adenosylmethionine binding site [chemical binding]; other site 498214005537 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 498214005538 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 498214005539 putative dimer interface [polypeptide binding]; other site 498214005540 Major Facilitator Superfamily; Region: MFS_1; pfam07690 498214005541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498214005542 putative substrate translocation pore; other site 498214005543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498214005544 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498214005545 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498214005546 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 498214005547 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 498214005548 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 498214005549 putative substrate binding site [chemical binding]; other site 498214005550 putative ATP binding site [chemical binding]; other site 498214005551 Major Facilitator Superfamily; Region: MFS_1; pfam07690 498214005552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498214005553 putative substrate translocation pore; other site 498214005554 Putative amidase domain; Region: Amidase_6; pfam12671 498214005555 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 498214005556 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 498214005557 substrate binding site [chemical binding]; other site 498214005558 ATP binding site [chemical binding]; other site 498214005559 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 498214005560 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 498214005561 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 498214005562 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 498214005563 DNA-binding site [nucleotide binding]; DNA binding site 498214005564 RNA-binding motif; other site 498214005565 Cache domain; Region: Cache_1; pfam02743 498214005566 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 498214005567 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214005568 dimer interface [polypeptide binding]; other site 498214005569 putative CheW interface [polypeptide binding]; other site 498214005570 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 498214005571 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498214005572 Pecanex protein (C-terminus); Region: Pecanex_C; pfam05041 498214005573 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498214005574 ABC transporter; Region: ABC_tran_2; pfam12848 498214005575 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498214005576 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 498214005577 putative deacylase active site [active] 498214005578 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 498214005579 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 498214005580 4Fe-4S binding domain; Region: Fer4_6; pfam12837 498214005581 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 498214005582 Response regulator receiver domain; Region: Response_reg; pfam00072 498214005583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214005584 active site 498214005585 phosphorylation site [posttranslational modification] 498214005586 intermolecular recognition site; other site 498214005587 dimerization interface [polypeptide binding]; other site 498214005588 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 498214005589 DEAD-like helicases superfamily; Region: DEXDc; smart00487 498214005590 ATP binding site [chemical binding]; other site 498214005591 putative Mg++ binding site [ion binding]; other site 498214005592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498214005593 nucleotide binding region [chemical binding]; other site 498214005594 ATP-binding site [chemical binding]; other site 498214005595 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 498214005596 S1 domain; Region: S1_2; pfam13509 498214005597 S1 domain; Region: S1_2; pfam13509 498214005598 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 498214005599 RNA binding site [nucleotide binding]; other site 498214005600 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 498214005601 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 498214005602 ATP binding site [chemical binding]; other site 498214005603 Mg++ binding site [ion binding]; other site 498214005604 motif III; other site 498214005605 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498214005606 nucleotide binding region [chemical binding]; other site 498214005607 ATP-binding site [chemical binding]; other site 498214005608 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 498214005609 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 498214005610 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498214005611 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498214005612 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498214005613 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498214005614 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 498214005615 Leucine rich repeat; Region: LRR_8; pfam13855 498214005616 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498214005617 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498214005618 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498214005619 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 498214005620 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 498214005621 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 498214005622 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 498214005623 Ferritin-like domain; Region: Ferritin; pfam00210 498214005624 ferroxidase diiron center [ion binding]; other site 498214005625 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 498214005626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214005627 active site 498214005628 phosphorylation site [posttranslational modification] 498214005629 intermolecular recognition site; other site 498214005630 dimerization interface [polypeptide binding]; other site 498214005631 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 498214005632 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 498214005633 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 498214005634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 498214005635 Nucleoside recognition; Region: Gate; pfam07670 498214005636 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 498214005637 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 498214005638 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 498214005639 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 498214005640 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 498214005641 active site 498214005642 DNA binding site [nucleotide binding] 498214005643 Int/Topo IB signature motif; other site 498214005644 LexA repressor; Validated; Region: PRK00215 498214005645 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 498214005646 putative Zn2+ binding site [ion binding]; other site 498214005647 putative DNA binding site [nucleotide binding]; other site 498214005648 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 498214005649 Catalytic site [active] 498214005650 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 498214005651 Aluminium resistance protein; Region: Alum_res; pfam06838 498214005652 bacterial Hfq-like; Region: Hfq; cd01716 498214005653 hexamer interface [polypeptide binding]; other site 498214005654 Sm1 motif; other site 498214005655 RNA binding site [nucleotide binding]; other site 498214005656 Sm2 motif; other site 498214005657 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 498214005658 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 498214005659 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 498214005660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214005661 ATP binding site [chemical binding]; other site 498214005662 Mg2+ binding site [ion binding]; other site 498214005663 G-X-G motif; other site 498214005664 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 498214005665 ATP binding site [chemical binding]; other site 498214005666 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 498214005667 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 498214005668 MutS domain I; Region: MutS_I; pfam01624 498214005669 MutS domain II; Region: MutS_II; pfam05188 498214005670 MutS domain III; Region: MutS_III; pfam05192 498214005671 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 498214005672 Walker A/P-loop; other site 498214005673 ATP binding site [chemical binding]; other site 498214005674 Q-loop/lid; other site 498214005675 ABC transporter signature motif; other site 498214005676 Walker B; other site 498214005677 D-loop; other site 498214005678 H-loop/switch region; other site 498214005679 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 498214005680 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 498214005681 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214005682 FeS/SAM binding site; other site 498214005683 TRAM domain; Region: TRAM; pfam01938 498214005684 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 498214005685 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498214005686 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214005687 homodimer interface [polypeptide binding]; other site 498214005688 catalytic residue [active] 498214005689 aspartate aminotransferase; Provisional; Region: PRK07568 498214005690 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498214005691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214005692 homodimer interface [polypeptide binding]; other site 498214005693 catalytic residue [active] 498214005694 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 498214005695 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 498214005696 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 498214005697 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 498214005698 LytB protein; Region: LYTB; cl00507 498214005699 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 498214005700 RNA binding site [nucleotide binding]; other site 498214005701 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 498214005702 RNA binding site [nucleotide binding]; other site 498214005703 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 498214005704 RNA binding site [nucleotide binding]; other site 498214005705 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 498214005706 RNA binding site [nucleotide binding]; other site 498214005707 domain interface; other site 498214005708 cytidylate kinase; Provisional; Region: cmk; PRK00023 498214005709 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 498214005710 CMP-binding site; other site 498214005711 The sites determining sugar specificity; other site 498214005712 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 498214005713 homotrimer interaction site [polypeptide binding]; other site 498214005714 active site 498214005715 flavoprotein, HI0933 family; Region: TIGR00275 498214005716 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 498214005717 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 498214005718 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 498214005719 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 498214005720 NAD(P) binding site [chemical binding]; other site 498214005721 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 498214005722 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 498214005723 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 498214005724 putative active site [active] 498214005725 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 498214005726 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 498214005727 RNA binding surface [nucleotide binding]; other site 498214005728 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 498214005729 active site 498214005730 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 498214005731 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 498214005732 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 498214005733 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 498214005734 DXD motif; other site 498214005735 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 498214005736 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214005737 dimerization interface [polypeptide binding]; other site 498214005738 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214005739 dimer interface [polypeptide binding]; other site 498214005740 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 498214005741 putative CheW interface [polypeptide binding]; other site 498214005742 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 498214005743 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 498214005744 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 498214005745 catalytic residues [active] 498214005746 Predicted amidohydrolase [General function prediction only]; Region: COG0388 498214005747 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 498214005748 putative active site [active] 498214005749 catalytic triad [active] 498214005750 dimer interface [polypeptide binding]; other site 498214005751 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 498214005752 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 498214005753 TrkA-C domain; Region: TrkA_C; pfam02080 498214005754 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 498214005755 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 498214005756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214005757 Coenzyme A binding pocket [chemical binding]; other site 498214005758 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 498214005759 active site residue [active] 498214005760 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 498214005761 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 498214005762 dimer interface [polypeptide binding]; other site 498214005763 [2Fe-2S] cluster binding site [ion binding]; other site 498214005764 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 498214005765 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498214005766 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 498214005767 Putative Fe-S cluster; Region: FeS; cl17515 498214005768 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498214005769 putative active site [active] 498214005770 heme pocket [chemical binding]; other site 498214005771 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 498214005772 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 498214005773 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498214005774 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 498214005775 Putative Fe-S cluster; Region: FeS; cl17515 498214005776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498214005777 putative active site [active] 498214005778 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 498214005779 dimerization interface [polypeptide binding]; other site 498214005780 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 498214005781 ATP binding site [chemical binding]; other site 498214005782 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 498214005783 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 498214005784 HupF/HypC family; Region: HupF_HypC; pfam01455 498214005785 Acylphosphatase; Region: Acylphosphatase; pfam00708 498214005786 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 498214005787 HypF finger; Region: zf-HYPF; pfam07503 498214005788 HypF finger; Region: zf-HYPF; pfam07503 498214005789 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 498214005790 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 498214005791 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 498214005792 nickel binding site [ion binding]; other site 498214005793 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 498214005794 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 498214005795 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 498214005796 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 498214005797 TraX protein; Region: TraX; pfam05857 498214005798 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 498214005799 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 498214005800 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 498214005801 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 498214005802 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 498214005803 ATP-grasp domain; Region: ATP-grasp_4; cl17255 498214005804 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 498214005805 IMP binding site; other site 498214005806 dimer interface [polypeptide binding]; other site 498214005807 interdomain contacts; other site 498214005808 partial ornithine binding site; other site 498214005809 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 498214005810 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 498214005811 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 498214005812 catalytic site [active] 498214005813 subunit interface [polypeptide binding]; other site 498214005814 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 498214005815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214005816 ABC transporter signature motif; other site 498214005817 Walker B; other site 498214005818 D-loop; other site 498214005819 H-loop/switch region; other site 498214005820 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 498214005821 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498214005822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214005823 Walker A/P-loop; other site 498214005824 ATP binding site [chemical binding]; other site 498214005825 Q-loop/lid; other site 498214005826 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498214005827 ABC transporter signature motif; other site 498214005828 ABC transporter; Region: ABC_tran_2; pfam12848 498214005829 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498214005830 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 498214005831 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 498214005832 catalytic loop [active] 498214005833 iron binding site [ion binding]; other site 498214005834 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 498214005835 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 498214005836 4Fe-4S binding domain; Region: Fer4; pfam00037 498214005837 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 498214005838 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 498214005839 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 498214005840 dimer interface [polypeptide binding]; other site 498214005841 [2Fe-2S] cluster binding site [ion binding]; other site 498214005842 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 498214005843 SLBB domain; Region: SLBB; pfam10531 498214005844 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 498214005845 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 498214005846 4Fe-4S binding domain; Region: Fer4; pfam00037 498214005847 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 498214005848 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 498214005849 putative dimer interface [polypeptide binding]; other site 498214005850 [2Fe-2S] cluster binding site [ion binding]; other site 498214005851 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 498214005852 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 498214005853 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 498214005854 Domain of unknown function DUF20; Region: UPF0118; pfam01594 498214005855 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 498214005856 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 498214005857 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 498214005858 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 498214005859 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 498214005860 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 498214005861 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 498214005862 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 498214005863 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 498214005864 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 498214005865 EcsC protein family; Region: EcsC; pfam12787 498214005866 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 498214005867 putative catalytic site [active] 498214005868 putative metal binding site [ion binding]; other site 498214005869 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 498214005870 putative catalytic site [active] 498214005871 putative phosphate binding site [ion binding]; other site 498214005872 putative phosphate binding site [ion binding]; other site 498214005873 putative metal binding site [ion binding]; other site 498214005874 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 498214005875 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 498214005876 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 498214005877 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 498214005878 purine nucleoside phosphorylase; Provisional; Region: PRK08202 498214005879 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 498214005880 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 498214005881 Int/Topo IB signature motif; other site 498214005882 active site 498214005883 stage II sporulation protein M; Region: spo_II_M; TIGR02831 498214005884 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 498214005885 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 498214005886 dimer interface [polypeptide binding]; other site 498214005887 ADP-ribose binding site [chemical binding]; other site 498214005888 active site 498214005889 nudix motif; other site 498214005890 metal binding site [ion binding]; metal-binding site 498214005891 inner membrane transporter YjeM; Provisional; Region: PRK15238 498214005892 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 498214005893 NlpC/P60 family; Region: NLPC_P60; pfam00877 498214005894 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 498214005895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214005896 active site 498214005897 phosphorylation site [posttranslational modification] 498214005898 intermolecular recognition site; other site 498214005899 dimerization interface [polypeptide binding]; other site 498214005900 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 498214005901 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 498214005902 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 498214005903 Homoserine O-succinyltransferase; Region: HTS; pfam04204 498214005904 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 498214005905 conserved cys residue [active] 498214005906 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 498214005907 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 498214005908 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 498214005909 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 498214005910 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 498214005911 homodimer interface [polypeptide binding]; other site 498214005912 substrate-cofactor binding pocket; other site 498214005913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214005914 catalytic residue [active] 498214005915 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 498214005916 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 498214005917 Walker A/P-loop; other site 498214005918 ATP binding site [chemical binding]; other site 498214005919 Q-loop/lid; other site 498214005920 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 498214005921 ABC transporter signature motif; other site 498214005922 Walker B; other site 498214005923 D-loop; other site 498214005924 H-loop/switch region; other site 498214005925 arginine repressor; Provisional; Region: argR; PRK00441 498214005926 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 498214005927 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 498214005928 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 498214005929 ATP-NAD kinase; Region: NAD_kinase; pfam01513 498214005930 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 498214005931 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 498214005932 RNA binding surface [nucleotide binding]; other site 498214005933 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 498214005934 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 498214005935 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 498214005936 TPP-binding site; other site 498214005937 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 498214005938 PYR/PP interface [polypeptide binding]; other site 498214005939 dimer interface [polypeptide binding]; other site 498214005940 TPP binding site [chemical binding]; other site 498214005941 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 498214005942 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 498214005943 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 498214005944 substrate binding pocket [chemical binding]; other site 498214005945 chain length determination region; other site 498214005946 substrate-Mg2+ binding site; other site 498214005947 catalytic residues [active] 498214005948 aspartate-rich region 1; other site 498214005949 active site lid residues [active] 498214005950 aspartate-rich region 2; other site 498214005951 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 498214005952 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 498214005953 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 498214005954 generic binding surface I; other site 498214005955 generic binding surface II; other site 498214005956 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 498214005957 putative RNA binding site [nucleotide binding]; other site 498214005958 Asp23 family; Region: Asp23; pfam03780 498214005959 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 498214005960 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 498214005961 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 498214005962 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 498214005963 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 498214005964 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 498214005965 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 498214005966 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 498214005967 elongation factor P; Validated; Region: PRK00529 498214005968 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 498214005969 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 498214005970 RNA binding site [nucleotide binding]; other site 498214005971 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 498214005972 RNA binding site [nucleotide binding]; other site 498214005973 Dehydroquinase class II; Region: DHquinase_II; pfam01220 498214005974 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 498214005975 trimer interface [polypeptide binding]; other site 498214005976 active site 498214005977 dimer interface [polypeptide binding]; other site 498214005978 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 498214005979 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 498214005980 ADP binding site [chemical binding]; other site 498214005981 magnesium binding site [ion binding]; other site 498214005982 putative shikimate binding site; other site 498214005983 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 498214005984 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 498214005985 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 498214005986 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 498214005987 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 498214005988 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 498214005989 Predicted ATPase [General function prediction only]; Region: COG5293 498214005990 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 498214005991 P63C domain; Region: P63C; pfam10546 498214005992 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 498214005993 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 498214005994 TIGR04255 family protein; Region: sporadTIGR04255 498214005995 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 498214005996 active site 498214005997 DNA binding site [nucleotide binding] 498214005998 Int/Topo IB signature motif; other site 498214005999 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 498214006000 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 498214006001 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 498214006002 Int/Topo IB signature motif; other site 498214006003 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 498214006004 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 498214006005 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 498214006006 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 498214006007 Walker A motif; other site 498214006008 ATP binding site [chemical binding]; other site 498214006009 Walker B motif; other site 498214006010 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 498214006011 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 498214006012 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 498214006013 active site 498214006014 Holin family; Region: Phage_holin_4; pfam05105 498214006015 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 498214006016 MAEBL; Provisional; Region: PTZ00121 498214006017 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 498214006018 Phage-related protein [Function unknown]; Region: COG4722 498214006019 Phage tail protein; Region: Sipho_tail; cl17486 498214006020 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 498214006021 Phage-related protein [Function unknown]; Region: COG5412 498214006022 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 498214006023 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 498214006024 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 498214006025 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 498214006026 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 498214006027 multiple promoter invertase; Provisional; Region: mpi; PRK13413 498214006028 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 498214006029 catalytic residues [active] 498214006030 catalytic nucleophile [active] 498214006031 Presynaptic Site I dimer interface [polypeptide binding]; other site 498214006032 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 498214006033 Synaptic Flat tetramer interface [polypeptide binding]; other site 498214006034 Synaptic Site I dimer interface [polypeptide binding]; other site 498214006035 DNA binding site [nucleotide binding] 498214006036 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 498214006037 Winged helix-turn helix; Region: HTH_29; pfam13551 498214006038 CHC2 zinc finger; Region: zf-CHC2; cl17510 498214006039 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 498214006040 ERCC4 domain; Region: ERCC4; pfam02732 498214006041 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 498214006042 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 498214006043 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 498214006044 dimer interface [polypeptide binding]; other site 498214006045 ssDNA binding site [nucleotide binding]; other site 498214006046 tetramer (dimer of dimers) interface [polypeptide binding]; other site 498214006047 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 498214006048 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 498214006049 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 498214006050 RecT family; Region: RecT; cl04285 498214006051 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214006052 Walker A/P-loop; other site 498214006053 ATP binding site [chemical binding]; other site 498214006054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 498214006055 DNA binding residues [nucleotide binding] 498214006056 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 498214006057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214006058 non-specific DNA binding site [nucleotide binding]; other site 498214006059 salt bridge; other site 498214006060 sequence-specific DNA binding site [nucleotide binding]; other site 498214006061 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214006062 non-specific DNA binding site [nucleotide binding]; other site 498214006063 salt bridge; other site 498214006064 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 498214006065 sequence-specific DNA binding site [nucleotide binding]; other site 498214006066 Domain of unknown function (DUF955); Region: DUF955; pfam06114 498214006067 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 498214006068 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 498214006069 Int/Topo IB signature motif; other site 498214006070 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 498214006071 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 498214006072 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 498214006073 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 498214006074 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 498214006075 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 498214006076 Domain of unknown function (DUF814); Region: DUF814; pfam05670 498214006077 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 498214006078 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 498214006079 dimerization interface 3.5A [polypeptide binding]; other site 498214006080 active site 498214006081 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 498214006082 nucleotide binding site/active site [active] 498214006083 HIT family signature motif; other site 498214006084 catalytic residue [active] 498214006085 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 498214006086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214006087 catalytic residue [active] 498214006088 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 498214006089 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 498214006090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214006091 dimerization interface [polypeptide binding]; other site 498214006092 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214006093 dimer interface [polypeptide binding]; other site 498214006094 putative CheW interface [polypeptide binding]; other site 498214006095 clostripain; Region: clostrip; TIGR02806 498214006096 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 498214006097 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214006098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214006099 active site 498214006100 phosphorylation site [posttranslational modification] 498214006101 intermolecular recognition site; other site 498214006102 dimerization interface [polypeptide binding]; other site 498214006103 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214006104 DNA binding site [nucleotide binding] 498214006105 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214006106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214006107 dimer interface [polypeptide binding]; other site 498214006108 phosphorylation site [posttranslational modification] 498214006109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214006110 ATP binding site [chemical binding]; other site 498214006111 Mg2+ binding site [ion binding]; other site 498214006112 G-X-G motif; other site 498214006113 methionine sulfoxide reductase A; Provisional; Region: PRK14054 498214006114 Response regulator receiver domain; Region: Response_reg; pfam00072 498214006115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214006116 active site 498214006117 phosphorylation site [posttranslational modification] 498214006118 intermolecular recognition site; other site 498214006119 dimerization interface [polypeptide binding]; other site 498214006120 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 498214006121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214006122 active site 498214006123 phosphorylation site [posttranslational modification] 498214006124 intermolecular recognition site; other site 498214006125 dimerization interface [polypeptide binding]; other site 498214006126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214006127 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214006128 dimerization interface [polypeptide binding]; other site 498214006129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214006130 dimer interface [polypeptide binding]; other site 498214006131 phosphorylation site [posttranslational modification] 498214006132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214006133 ATP binding site [chemical binding]; other site 498214006134 Mg2+ binding site [ion binding]; other site 498214006135 G-X-G motif; other site 498214006136 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214006137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214006138 active site 498214006139 phosphorylation site [posttranslational modification] 498214006140 intermolecular recognition site; other site 498214006141 dimerization interface [polypeptide binding]; other site 498214006142 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214006143 DNA binding site [nucleotide binding] 498214006144 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 498214006145 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 498214006146 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 498214006147 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 498214006148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214006149 Walker A/P-loop; other site 498214006150 ATP binding site [chemical binding]; other site 498214006151 Q-loop/lid; other site 498214006152 ABC transporter signature motif; other site 498214006153 Walker B; other site 498214006154 D-loop; other site 498214006155 H-loop/switch region; other site 498214006156 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 498214006157 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 498214006158 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 498214006159 Walker A/P-loop; other site 498214006160 ATP binding site [chemical binding]; other site 498214006161 Q-loop/lid; other site 498214006162 ABC transporter signature motif; other site 498214006163 Walker B; other site 498214006164 D-loop; other site 498214006165 H-loop/switch region; other site 498214006166 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 498214006167 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 498214006168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214006169 Walker A/P-loop; other site 498214006170 ATP binding site [chemical binding]; other site 498214006171 Q-loop/lid; other site 498214006172 ABC transporter signature motif; other site 498214006173 Walker B; other site 498214006174 D-loop; other site 498214006175 H-loop/switch region; other site 498214006176 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 498214006177 MarR family; Region: MarR; pfam01047 498214006178 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 498214006179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214006180 Coenzyme A binding pocket [chemical binding]; other site 498214006181 hypothetical protein; Provisional; Region: PRK08328 498214006182 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 498214006183 ATP binding site [chemical binding]; other site 498214006184 substrate interface [chemical binding]; other site 498214006185 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 498214006186 MoaE interaction surface [polypeptide binding]; other site 498214006187 MoeB interaction surface [polypeptide binding]; other site 498214006188 thiocarboxylated glycine; other site 498214006189 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 498214006190 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 498214006191 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 498214006192 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 498214006193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498214006194 putative active site [active] 498214006195 heme pocket [chemical binding]; other site 498214006196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214006197 Walker A motif; other site 498214006198 ATP binding site [chemical binding]; other site 498214006199 Walker B motif; other site 498214006200 arginine finger; other site 498214006201 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 498214006202 MOSC domain; Region: MOSC; pfam03473 498214006203 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cd00528 498214006204 trimer interface [polypeptide binding]; other site 498214006205 dimer interface [polypeptide binding]; other site 498214006206 putative active site [active] 498214006207 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 498214006208 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214006209 FeS/SAM binding site; other site 498214006210 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 498214006211 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 498214006212 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 498214006213 dimer interface [polypeptide binding]; other site 498214006214 putative functional site; other site 498214006215 putative MPT binding site; other site 498214006216 PBP superfamily domain; Region: PBP_like; pfam12727 498214006217 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 498214006218 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 498214006219 dimer interface [polypeptide binding]; other site 498214006220 putative functional site; other site 498214006221 putative MPT binding site; other site 498214006222 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 498214006223 MPT binding site; other site 498214006224 trimer interface [polypeptide binding]; other site 498214006225 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 498214006226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214006227 Walker A/P-loop; other site 498214006228 ATP binding site [chemical binding]; other site 498214006229 Q-loop/lid; other site 498214006230 ABC transporter signature motif; other site 498214006231 Walker B; other site 498214006232 D-loop; other site 498214006233 H-loop/switch region; other site 498214006234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214006235 dimer interface [polypeptide binding]; other site 498214006236 conserved gate region; other site 498214006237 putative PBP binding loops; other site 498214006238 ABC-ATPase subunit interface; other site 498214006239 PBP superfamily domain; Region: PBP_like_2; pfam12849 498214006240 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 498214006241 putative efflux protein, MATE family; Region: matE; TIGR00797 498214006242 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 498214006243 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214006244 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498214006245 Walker A/P-loop; other site 498214006246 ATP binding site [chemical binding]; other site 498214006247 Q-loop/lid; other site 498214006248 ABC transporter signature motif; other site 498214006249 Walker B; other site 498214006250 D-loop; other site 498214006251 H-loop/switch region; other site 498214006252 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 498214006253 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 498214006254 FtsX-like permease family; Region: FtsX; pfam02687 498214006255 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 498214006256 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 498214006257 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 498214006258 Walker A/P-loop; other site 498214006259 ATP binding site [chemical binding]; other site 498214006260 Q-loop/lid; other site 498214006261 ABC transporter signature motif; other site 498214006262 Walker B; other site 498214006263 D-loop; other site 498214006264 H-loop/switch region; other site 498214006265 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 498214006266 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 498214006267 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214006268 Walker A/P-loop; other site 498214006269 ATP binding site [chemical binding]; other site 498214006270 Q-loop/lid; other site 498214006271 ABC transporter signature motif; other site 498214006272 Walker B; other site 498214006273 D-loop; other site 498214006274 H-loop/switch region; other site 498214006275 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 498214006276 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 498214006277 DNA binding residues [nucleotide binding] 498214006278 dimer interface [polypeptide binding]; other site 498214006279 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 498214006280 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 498214006281 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 498214006282 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498214006283 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498214006284 M6 family metalloprotease domain; Region: M6dom_TIGR03296 498214006285 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 498214006286 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 498214006287 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 498214006288 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 498214006289 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498214006290 motif II; other site 498214006291 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 498214006292 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 498214006293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498214006294 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 498214006295 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498214006296 Leucine-rich repeats; other site 498214006297 Leucine rich repeat; Region: LRR_8; pfam13855 498214006298 Substrate binding site [chemical binding]; other site 498214006299 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498214006300 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498214006301 M6 family metalloprotease domain; Region: M6dom_TIGR03296 498214006302 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 498214006303 dimerization interface [polypeptide binding]; other site 498214006304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214006305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214006306 dimer interface [polypeptide binding]; other site 498214006307 phosphorylation site [posttranslational modification] 498214006308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214006309 ATP binding site [chemical binding]; other site 498214006310 Mg2+ binding site [ion binding]; other site 498214006311 G-X-G motif; other site 498214006312 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214006313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214006314 active site 498214006315 phosphorylation site [posttranslational modification] 498214006316 intermolecular recognition site; other site 498214006317 dimerization interface [polypeptide binding]; other site 498214006318 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214006319 DNA binding site [nucleotide binding] 498214006320 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 498214006321 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 498214006322 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 498214006323 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 498214006324 Walker A/P-loop; other site 498214006325 ATP binding site [chemical binding]; other site 498214006326 Q-loop/lid; other site 498214006327 ABC transporter signature motif; other site 498214006328 Walker B; other site 498214006329 D-loop; other site 498214006330 H-loop/switch region; other site 498214006331 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 498214006332 Walker A/P-loop; other site 498214006333 ATP binding site [chemical binding]; other site 498214006334 Q-loop/lid; other site 498214006335 ABC transporter signature motif; other site 498214006336 Walker B; other site 498214006337 D-loop; other site 498214006338 H-loop/switch region; other site 498214006339 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 498214006340 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 498214006341 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 498214006342 dimer interface [polypeptide binding]; other site 498214006343 active site 498214006344 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 498214006345 substrate binding site [chemical binding]; other site 498214006346 catalytic residue [active] 498214006347 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 498214006348 Spore germination protein; Region: Spore_permease; cl17796 498214006349 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 498214006350 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 498214006351 Spore germination protein; Region: Spore_permease; cl17796 498214006352 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 498214006353 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 498214006354 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 498214006355 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214006356 FeS/SAM binding site; other site 498214006357 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 498214006358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 498214006359 binding surface 498214006360 TPR repeat; Region: TPR_11; pfam13414 498214006361 TPR motif; other site 498214006362 Tetratricopeptide repeat; Region: TPR_16; pfam13432 498214006363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 498214006364 binding surface 498214006365 TPR motif; other site 498214006366 TPR repeat; Region: TPR_11; pfam13414 498214006367 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 498214006368 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 498214006369 TrkA-C domain; Region: TrkA_C; pfam02080 498214006370 heat shock protein 90; Provisional; Region: PRK05218 498214006371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214006372 ATP binding site [chemical binding]; other site 498214006373 Mg2+ binding site [ion binding]; other site 498214006374 G-X-G motif; other site 498214006375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214006376 Walker A/P-loop; other site 498214006377 ATP binding site [chemical binding]; other site 498214006378 Q-loop/lid; other site 498214006379 ABC transporter signature motif; other site 498214006380 Walker B; other site 498214006381 D-loop; other site 498214006382 H-loop/switch region; other site 498214006383 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 498214006384 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 498214006385 active site turn [active] 498214006386 phosphorylation site [posttranslational modification] 498214006387 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 498214006388 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 498214006389 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 498214006390 Ca binding site [ion binding]; other site 498214006391 active site 498214006392 catalytic site [active] 498214006393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214006394 DNA-binding site [nucleotide binding]; DNA binding site 498214006395 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 498214006396 UTRA domain; Region: UTRA; pfam07702 498214006397 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 498214006398 active site 498214006399 phosphorylation site [posttranslational modification] 498214006400 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 498214006401 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 498214006402 active site 498214006403 P-loop; other site 498214006404 phosphorylation site [posttranslational modification] 498214006405 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 498214006406 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 498214006407 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 498214006408 putative substrate binding site [chemical binding]; other site 498214006409 putative ATP binding site [chemical binding]; other site 498214006410 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 498214006411 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 498214006412 intersubunit interface [polypeptide binding]; other site 498214006413 active site 498214006414 zinc binding site [ion binding]; other site 498214006415 Na+ binding site [ion binding]; other site 498214006416 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 498214006417 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 498214006418 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 498214006419 putative active site [active] 498214006420 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 498214006421 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 498214006422 homotrimer interaction site [polypeptide binding]; other site 498214006423 putative active site [active] 498214006424 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214006425 Radical SAM superfamily; Region: Radical_SAM; pfam04055 498214006426 FeS/SAM binding site; other site 498214006427 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 498214006428 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 498214006429 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 498214006430 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 498214006431 dimer interface [polypeptide binding]; other site 498214006432 active site 498214006433 metal binding site [ion binding]; metal-binding site 498214006434 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214006435 dimerization interface [polypeptide binding]; other site 498214006436 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498214006437 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214006438 dimer interface [polypeptide binding]; other site 498214006439 putative CheW interface [polypeptide binding]; other site 498214006440 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 498214006441 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 498214006442 dimer interface [polypeptide binding]; other site 498214006443 active site 498214006444 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 498214006445 substrate binding site [chemical binding]; other site 498214006446 catalytic residue [active] 498214006447 ATP cone domain; Region: ATP-cone; pfam03477 498214006448 putative oxidoreductase; Provisional; Region: PRK11579 498214006449 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 498214006450 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 498214006451 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498214006452 active site 498214006453 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 498214006454 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 498214006455 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 498214006456 metal binding site [ion binding]; metal-binding site 498214006457 active site 498214006458 I-site; other site 498214006459 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 498214006460 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 498214006461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 498214006462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214006463 Walker A motif; other site 498214006464 ATP binding site [chemical binding]; other site 498214006465 Walker B motif; other site 498214006466 arginine finger; other site 498214006467 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 498214006468 DEAD-like helicases superfamily; Region: DEXDc; smart00487 498214006469 ATP binding site [chemical binding]; other site 498214006470 Mg++ binding site [ion binding]; other site 498214006471 motif III; other site 498214006472 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498214006473 nucleotide binding region [chemical binding]; other site 498214006474 ATP-binding site [chemical binding]; other site 498214006475 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 498214006476 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 498214006477 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 498214006478 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214006479 DNA-binding site [nucleotide binding]; DNA binding site 498214006480 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498214006481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214006482 homodimer interface [polypeptide binding]; other site 498214006483 catalytic residue [active] 498214006484 EamA-like transporter family; Region: EamA; pfam00892 498214006485 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 498214006486 EamA-like transporter family; Region: EamA; cl17759 498214006487 aspartate aminotransferase; Provisional; Region: PRK06348 498214006488 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498214006489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214006490 homodimer interface [polypeptide binding]; other site 498214006491 catalytic residue [active] 498214006492 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 498214006493 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 498214006494 Walker A/P-loop; other site 498214006495 ATP binding site [chemical binding]; other site 498214006496 Q-loop/lid; other site 498214006497 ABC transporter signature motif; other site 498214006498 Walker B; other site 498214006499 D-loop; other site 498214006500 H-loop/switch region; other site 498214006501 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 498214006502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214006503 dimer interface [polypeptide binding]; other site 498214006504 conserved gate region; other site 498214006505 putative PBP binding loops; other site 498214006506 ABC-ATPase subunit interface; other site 498214006507 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 498214006508 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 498214006509 substrate binding pocket [chemical binding]; other site 498214006510 membrane-bound complex binding site; other site 498214006511 hinge residues; other site 498214006512 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 498214006513 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 498214006514 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498214006515 catalytic residue [active] 498214006516 Chloramphenicol acetyltransferase; Region: CAT; cl02008 498214006517 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 498214006518 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 498214006519 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 498214006520 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 498214006521 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498214006522 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498214006523 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 498214006524 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 498214006525 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 498214006526 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 498214006527 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 498214006528 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 498214006529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214006530 non-specific DNA binding site [nucleotide binding]; other site 498214006531 salt bridge; other site 498214006532 sequence-specific DNA binding site [nucleotide binding]; other site 498214006533 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 498214006534 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 498214006535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498214006536 putative substrate translocation pore; other site 498214006537 Major Facilitator Superfamily; Region: MFS_1; pfam07690 498214006538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498214006539 putative substrate translocation pore; other site 498214006540 POT family; Region: PTR2; cl17359 498214006541 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 498214006542 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 498214006543 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 498214006544 active site 498214006545 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 498214006546 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 498214006547 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 498214006548 Na2 binding site [ion binding]; other site 498214006549 putative substrate binding site 1 [chemical binding]; other site 498214006550 Na binding site 1 [ion binding]; other site 498214006551 putative substrate binding site 2 [chemical binding]; other site 498214006552 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 498214006553 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 498214006554 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214006555 DNA-binding site [nucleotide binding]; DNA binding site 498214006556 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498214006557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214006558 homodimer interface [polypeptide binding]; other site 498214006559 catalytic residue [active] 498214006560 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 498214006561 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 498214006562 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 498214006563 nucleophilic elbow; other site 498214006564 catalytic triad; other site 498214006565 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 498214006566 putative FMN binding site [chemical binding]; other site 498214006567 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 498214006568 metal ion-dependent adhesion site (MIDAS); other site 498214006569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 498214006570 myosin-cross-reactive antigen; Provisional; Region: PRK13977 498214006571 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 498214006572 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498214006573 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 498214006574 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 498214006575 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 498214006576 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498214006577 catalytic residue [active] 498214006578 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 498214006579 active site 498214006580 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 498214006581 active site 498214006582 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 498214006583 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 498214006584 putative trimer interface [polypeptide binding]; other site 498214006585 putative CoA binding site [chemical binding]; other site 498214006586 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 498214006587 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 498214006588 inhibitor-cofactor binding pocket; inhibition site 498214006589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214006590 catalytic residue [active] 498214006591 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 498214006592 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 498214006593 active site 498214006594 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 498214006595 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 498214006596 substrate binding site; other site 498214006597 metal-binding site 498214006598 Oligomer interface; other site 498214006599 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 498214006600 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 498214006601 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 498214006602 NAD binding site [chemical binding]; other site 498214006603 substrate binding site [chemical binding]; other site 498214006604 homodimer interface [polypeptide binding]; other site 498214006605 active site 498214006606 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 498214006607 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 498214006608 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 498214006609 PGAP1-like protein; Region: PGAP1; pfam07819 498214006610 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 498214006611 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 498214006612 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 498214006613 Walker A/P-loop; other site 498214006614 ATP binding site [chemical binding]; other site 498214006615 Q-loop/lid; other site 498214006616 ABC transporter signature motif; other site 498214006617 Walker B; other site 498214006618 D-loop; other site 498214006619 H-loop/switch region; other site 498214006620 Predicted transcriptional regulators [Transcription]; Region: COG1725 498214006621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214006622 DNA-binding site [nucleotide binding]; DNA binding site 498214006623 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 498214006624 glycosyltransferase, MGT family; Region: MGT; TIGR01426 498214006625 active site 498214006626 TDP-binding site; other site 498214006627 acceptor substrate-binding pocket; other site 498214006628 homodimer interface [polypeptide binding]; other site 498214006629 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 498214006630 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 498214006631 Probable transposase; Region: OrfB_IS605; pfam01385 498214006632 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 498214006633 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 498214006634 Radical SAM superfamily; Region: Radical_SAM; pfam04055 498214006635 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214006636 FeS/SAM binding site; other site 498214006637 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 498214006638 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 498214006639 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 498214006640 Walker A/P-loop; other site 498214006641 ATP binding site [chemical binding]; other site 498214006642 Q-loop/lid; other site 498214006643 ABC transporter signature motif; other site 498214006644 Walker B; other site 498214006645 D-loop; other site 498214006646 H-loop/switch region; other site 498214006647 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 498214006648 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 498214006649 Walker A/P-loop; other site 498214006650 ATP binding site [chemical binding]; other site 498214006651 Q-loop/lid; other site 498214006652 ABC transporter signature motif; other site 498214006653 Walker B; other site 498214006654 D-loop; other site 498214006655 H-loop/switch region; other site 498214006656 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 498214006657 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 498214006658 Helix-turn-helix domain; Region: HTH_18; pfam12833 498214006659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214006660 Protein of unknown function; Region: DUF3658; pfam12395 498214006661 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 498214006662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214006663 Coenzyme A binding pocket [chemical binding]; other site 498214006664 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 498214006665 active site 498214006666 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 498214006667 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 498214006668 HsdM N-terminal domain; Region: HsdM_N; pfam12161 498214006669 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 498214006670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214006671 S-adenosylmethionine binding site [chemical binding]; other site 498214006672 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 498214006673 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 498214006674 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 498214006675 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498214006676 ATP binding site [chemical binding]; other site 498214006677 putative Mg++ binding site [ion binding]; other site 498214006678 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 498214006679 active site 498214006680 NTP binding site [chemical binding]; other site 498214006681 nucleic acid binding site [nucleotide binding]; other site 498214006682 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 498214006683 active site 498214006684 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214006685 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214006686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214006687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 498214006688 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 498214006689 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 498214006690 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 498214006691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 498214006692 NAD(P) binding site [chemical binding]; other site 498214006693 active site 498214006694 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 498214006695 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 498214006696 active site 498214006697 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 498214006698 active site 498214006699 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 498214006700 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 498214006701 active site 498214006702 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 498214006703 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 498214006704 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 498214006705 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 498214006706 G1 box; other site 498214006707 putative GEF interaction site [polypeptide binding]; other site 498214006708 GTP/Mg2+ binding site [chemical binding]; other site 498214006709 Switch I region; other site 498214006710 G2 box; other site 498214006711 G3 box; other site 498214006712 Switch II region; other site 498214006713 G4 box; other site 498214006714 G5 box; other site 498214006715 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 498214006716 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 498214006717 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 498214006718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214006719 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 498214006720 DNA-binding site [nucleotide binding]; DNA binding site 498214006721 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498214006722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214006723 homodimer interface [polypeptide binding]; other site 498214006724 catalytic residue [active] 498214006725 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 498214006726 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 498214006727 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 498214006728 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 498214006729 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 498214006730 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 498214006731 aromatic chitin/cellulose binding site residues [chemical binding]; other site 498214006732 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 498214006733 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 498214006734 Soluble P-type ATPase [General function prediction only]; Region: COG4087 498214006735 Uncharacterized family 3; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_3; cd10160 498214006736 putative homodimer interface [polypeptide binding]; other site 498214006737 putative homotetramer interface [polypeptide binding]; other site 498214006738 putative metal binding site [ion binding]; other site 498214006739 putative homodimer-homodimer interface [polypeptide binding]; other site 498214006740 Hemerythrin; Region: Hemerythrin; cd12107 498214006741 Fe binding site [ion binding]; other site 498214006742 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 498214006743 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 498214006744 Hexamer interface [polypeptide binding]; other site 498214006745 Putative hexagonal pore residue; other site 498214006746 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 498214006747 Propanediol utilisation protein PduL; Region: PduL; pfam06130 498214006748 Propanediol utilisation protein PduL; Region: PduL; pfam06130 498214006749 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 498214006750 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 498214006751 putative catalytic cysteine [active] 498214006752 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 498214006753 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 498214006754 Hexamer interface [polypeptide binding]; other site 498214006755 Hexagonal pore residue; other site 498214006756 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 498214006757 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 498214006758 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 498214006759 Hexamer/Pentamer interface [polypeptide binding]; other site 498214006760 central pore; other site 498214006761 Bacterial Micro-Compartment (BMC)-like domain 2; Region: BMC_like_2; cd07055 498214006762 putative hexamer interface [polypeptide binding]; other site 498214006763 putative hexagonal pore; other site 498214006764 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 498214006765 Cell division protein FtsA; Region: FtsA; cl17206 498214006766 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 498214006767 nucleotide binding site [chemical binding]; other site 498214006768 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 498214006769 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 498214006770 G1 box; other site 498214006771 GTP/Mg2+ binding site [chemical binding]; other site 498214006772 G2 box; other site 498214006773 Switch I region; other site 498214006774 G3 box; other site 498214006775 Switch II region; other site 498214006776 G4 box; other site 498214006777 G5 box; other site 498214006778 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 498214006779 putative hexamer interface [polypeptide binding]; other site 498214006780 putative hexagonal pore; other site 498214006781 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 498214006782 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 498214006783 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 498214006784 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 498214006785 dimer interface [polypeptide binding]; other site 498214006786 active site 498214006787 glycine loop; other site 498214006788 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 498214006789 putative catalytic cysteine [active] 498214006790 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 498214006791 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 498214006792 Hexamer interface [polypeptide binding]; other site 498214006793 Hexagonal pore residue; other site 498214006794 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 498214006795 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 498214006796 Hexamer interface [polypeptide binding]; other site 498214006797 Hexagonal pore residue; other site 498214006798 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 498214006799 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 498214006800 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 498214006801 DNA binding residues [nucleotide binding] 498214006802 drug binding residues [chemical binding]; other site 498214006803 dimer interface [polypeptide binding]; other site 498214006804 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 498214006805 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 498214006806 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 498214006807 putative active site [active] 498214006808 metal binding site [ion binding]; metal-binding site 498214006809 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 498214006810 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 498214006811 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 498214006812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498214006813 putative substrate translocation pore; other site 498214006814 Transcriptional regulators [Transcription]; Region: FadR; COG2186 498214006815 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214006816 DNA-binding site [nucleotide binding]; DNA binding site 498214006817 FCD domain; Region: FCD; pfam07729 498214006818 MarR family; Region: MarR_2; pfam12802 498214006819 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214006820 Coenzyme A binding pocket [chemical binding]; other site 498214006821 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 498214006822 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 498214006823 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 498214006824 Helix-turn-helix domain; Region: HTH_17; pfam12728 498214006825 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 498214006826 active site 498214006827 catalytic site [active] 498214006828 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 498214006829 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 498214006830 active site 498214006831 putative oxidoreductase; Provisional; Region: PRK11445 498214006832 TrkA-N domain; Region: TrkA_N; pfam02254 498214006833 Predicted transcriptional regulator [Transcription]; Region: COG3655 498214006834 salt bridge; other site 498214006835 non-specific DNA binding site [nucleotide binding]; other site 498214006836 sequence-specific DNA binding site [nucleotide binding]; other site 498214006837 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 498214006838 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 498214006839 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 498214006840 NAD(P) binding site [chemical binding]; other site 498214006841 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 498214006842 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 498214006843 DNA interaction; other site 498214006844 Metal-binding active site; metal-binding site 498214006845 2-deoxy-scyllo-inosose synthase (DOIS) catalyzes carbocycle formation from D-glucose-6-phosphate to 2-deoxy-scyllo-inosose through a multistep reaction in the biosynthesis of aminoglycoside antibiotics; Region: DOIS; cd08197 498214006846 active site 498214006847 dimer interface [polypeptide binding]; other site 498214006848 metal binding site [ion binding]; metal-binding site 498214006849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214006850 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 498214006851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214006852 ATP binding site [chemical binding]; other site 498214006853 Mg2+ binding site [ion binding]; other site 498214006854 G-X-G motif; other site 498214006855 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214006856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214006857 active site 498214006858 phosphorylation site [posttranslational modification] 498214006859 intermolecular recognition site; other site 498214006860 dimerization interface [polypeptide binding]; other site 498214006861 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214006862 DNA binding site [nucleotide binding] 498214006863 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 498214006864 Zn binding site [ion binding]; other site 498214006865 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 498214006866 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 498214006867 Walker A/P-loop; other site 498214006868 ATP binding site [chemical binding]; other site 498214006869 Q-loop/lid; other site 498214006870 ABC transporter signature motif; other site 498214006871 Walker B; other site 498214006872 D-loop; other site 498214006873 H-loop/switch region; other site 498214006874 FtsX-like permease family; Region: FtsX; pfam02687 498214006875 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214006876 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498214006877 Walker A/P-loop; other site 498214006878 ATP binding site [chemical binding]; other site 498214006879 Q-loop/lid; other site 498214006880 ABC transporter signature motif; other site 498214006881 Walker B; other site 498214006882 D-loop; other site 498214006883 H-loop/switch region; other site 498214006884 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 498214006885 HTH domain; Region: HTH_11; pfam08279 498214006886 HTH domain; Region: HTH_11; pfam08279 498214006887 PRD domain; Region: PRD; pfam00874 498214006888 PRD domain; Region: PRD; pfam00874 498214006889 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 498214006890 active site 498214006891 P-loop; other site 498214006892 phosphorylation site [posttranslational modification] 498214006893 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 498214006894 active site 498214006895 phosphorylation site [posttranslational modification] 498214006896 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 498214006897 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 498214006898 active site 498214006899 P-loop; other site 498214006900 phosphorylation site [posttranslational modification] 498214006901 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 498214006902 active site 498214006903 phosphorylation site [posttranslational modification] 498214006904 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 498214006905 active site 498214006906 intersubunit interactions; other site 498214006907 catalytic residue [active] 498214006908 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 498214006909 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 498214006910 active site 498214006911 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 498214006912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498214006913 POT family; Region: PTR2; cl17359 498214006914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214006915 S-adenosylmethionine binding site [chemical binding]; other site 498214006916 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214006917 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214006918 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 498214006919 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 498214006920 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 498214006921 phosphate binding site [ion binding]; other site 498214006922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 498214006923 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 498214006924 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 498214006925 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 498214006926 DNA binding residues [nucleotide binding] 498214006927 dimer interface [polypeptide binding]; other site 498214006928 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 498214006929 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 498214006930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214006931 Coenzyme A binding pocket [chemical binding]; other site 498214006932 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 498214006933 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 498214006934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214006935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 498214006936 Coenzyme A binding pocket [chemical binding]; other site 498214006937 Staygreen protein; Region: Staygreen; pfam12638 498214006938 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 498214006939 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 498214006940 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 498214006941 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 498214006942 Uncharacterized membrane protein [Function unknown]; Region: COG3949 498214006943 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 498214006944 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 498214006945 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 498214006946 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 498214006947 Ligand binding site [chemical binding]; other site 498214006948 Electron transfer flavoprotein domain; Region: ETF; pfam01012 498214006949 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 498214006950 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 498214006951 active site 498214006952 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 498214006953 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 498214006954 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 498214006955 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 498214006956 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 498214006957 CoA-transferase family III; Region: CoA_transf_3; pfam02515 498214006958 Flavodoxin domain; Region: Flavodoxin_5; cl17428 498214006959 Ferredoxin [Energy production and conversion]; Region: COG1146 498214006960 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 498214006961 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 498214006962 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 498214006963 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 498214006964 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 498214006965 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 498214006966 nucleotide binding site [chemical binding]; other site 498214006967 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 498214006968 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214006969 dimer interface [polypeptide binding]; other site 498214006970 putative CheW interface [polypeptide binding]; other site 498214006971 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 498214006972 dimer interface [polypeptide binding]; other site 498214006973 FMN binding site [chemical binding]; other site 498214006974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214006975 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 498214006976 Coenzyme A binding pocket [chemical binding]; other site 498214006977 FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364 498214006978 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 498214006979 dimer interface [polypeptide binding]; other site 498214006980 active site 498214006981 Mn binding site [ion binding]; other site 498214006982 GntP family permease; Region: GntP_permease; pfam02447 498214006983 fructuronate transporter; Provisional; Region: PRK10034; cl15264 498214006984 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 498214006985 Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995 498214006986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 498214006987 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 498214006988 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 498214006989 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 498214006990 CAAX protease self-immunity; Region: Abi; pfam02517 498214006991 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 498214006992 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 498214006993 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 498214006994 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 498214006995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498214006996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498214006997 WHG domain; Region: WHG; pfam13305 498214006998 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 498214006999 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 498214007000 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 498214007001 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 498214007002 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 498214007003 putative NAD(P) binding site [chemical binding]; other site 498214007004 catalytic Zn binding site [ion binding]; other site 498214007005 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 498214007006 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 498214007007 ACS interaction site; other site 498214007008 CODH interaction site; other site 498214007009 cubane metal cluster (B-cluster) [ion binding]; other site 498214007010 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 498214007011 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 498214007012 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 498214007013 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498214007014 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 498214007015 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 498214007016 P loop nucleotide binding; other site 498214007017 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 498214007018 switch II; other site 498214007019 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 498214007020 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 498214007021 P loop nucleotide binding; other site 498214007022 switch II; other site 498214007023 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 498214007024 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 498214007025 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 498214007026 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 498214007027 ligand binding site [chemical binding]; other site 498214007028 flagellar motor protein MotA; Validated; Region: PRK08124 498214007029 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 498214007030 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 498214007031 OPT oligopeptide transporter protein; Region: OPT; cl14607 498214007032 putative oligopeptide transporter, OPT family; Region: TIGR00733 498214007033 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 498214007034 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 498214007035 metal binding site [ion binding]; metal-binding site 498214007036 dimer interface [polypeptide binding]; other site 498214007037 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 498214007038 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 498214007039 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498214007040 catalytic residue [active] 498214007041 oxidoreductase; Provisional; Region: PRK08017 498214007042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 498214007043 NAD(P) binding site [chemical binding]; other site 498214007044 active site 498214007045 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 498214007046 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 498214007047 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 498214007048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214007049 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214007050 Walker A/P-loop; other site 498214007051 ATP binding site [chemical binding]; other site 498214007052 Q-loop/lid; other site 498214007053 ABC transporter signature motif; other site 498214007054 Walker B; other site 498214007055 D-loop; other site 498214007056 H-loop/switch region; other site 498214007057 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 498214007058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214007059 Coenzyme A binding pocket [chemical binding]; other site 498214007060 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 498214007061 MarR family; Region: MarR_2; pfam12802 498214007062 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 498214007063 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 498214007064 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 498214007065 Predicted dehydrogenase [General function prediction only]; Region: COG0579 498214007066 hydroxyglutarate oxidase; Provisional; Region: PRK11728 498214007067 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 498214007068 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 498214007069 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 498214007070 DNA binding residues [nucleotide binding] 498214007071 drug binding residues [chemical binding]; other site 498214007072 dimer interface [polypeptide binding]; other site 498214007073 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 498214007074 Amino acid permease; Region: AA_permease_2; pfam13520 498214007075 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 498214007076 putative ADP-ribose binding site [chemical binding]; other site 498214007077 putative active site [active] 498214007078 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 498214007079 MarR family; Region: MarR_2; cl17246 498214007080 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 498214007081 TIGR03987 family protein; Region: TIGR03987 498214007082 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498214007083 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 498214007084 substrate binding site [chemical binding]; other site 498214007085 multimerization interface [polypeptide binding]; other site 498214007086 ATP binding site [chemical binding]; other site 498214007087 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 498214007088 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 498214007089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214007090 Coenzyme A binding pocket [chemical binding]; other site 498214007091 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498214007092 Mor transcription activator family; Region: Mor; cl02360 498214007093 AAA domain; Region: AAA_26; pfam13500 498214007094 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 498214007095 biotin synthase; Region: bioB; TIGR00433 498214007096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214007097 FeS/SAM binding site; other site 498214007098 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 498214007099 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 498214007100 hypothetical protein; Provisional; Region: PRK09272 498214007101 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 498214007102 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 498214007103 putative DNA binding site [nucleotide binding]; other site 498214007104 putative Zn2+ binding site [ion binding]; other site 498214007105 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 498214007106 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 498214007107 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 498214007108 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 498214007109 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 498214007110 active site 498214007111 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 498214007112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 498214007113 putative substrate translocation pore; other site 498214007114 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 498214007115 YmaF family; Region: YmaF; pfam12788 498214007116 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 498214007117 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 498214007118 active site 498214007119 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 498214007120 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 498214007121 YmaF family; Region: YmaF; pfam12788 498214007122 hypothetical protein; Provisional; Region: PRK05802 498214007123 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 498214007124 FAD binding pocket [chemical binding]; other site 498214007125 FAD binding motif [chemical binding]; other site 498214007126 phosphate binding motif [ion binding]; other site 498214007127 beta-alpha-beta structure motif; other site 498214007128 NAD binding pocket [chemical binding]; other site 498214007129 Iron coordination center [ion binding]; other site 498214007130 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 498214007131 methionine sulfoxide reductase B; Provisional; Region: PRK00222 498214007132 SelR domain; Region: SelR; pfam01641 498214007133 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 498214007134 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 498214007135 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 498214007136 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 498214007137 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 498214007138 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 498214007139 Walker A/P-loop; other site 498214007140 ATP binding site [chemical binding]; other site 498214007141 Q-loop/lid; other site 498214007142 ABC transporter signature motif; other site 498214007143 Walker B; other site 498214007144 D-loop; other site 498214007145 H-loop/switch region; other site 498214007146 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 498214007147 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 498214007148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214007149 Walker A/P-loop; other site 498214007150 ATP binding site [chemical binding]; other site 498214007151 Q-loop/lid; other site 498214007152 ABC transporter signature motif; other site 498214007153 Walker B; other site 498214007154 D-loop; other site 498214007155 H-loop/switch region; other site 498214007156 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214007157 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214007158 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 498214007159 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 498214007160 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 498214007161 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 498214007162 Walker A/P-loop; other site 498214007163 ATP binding site [chemical binding]; other site 498214007164 Q-loop/lid; other site 498214007165 ABC transporter signature motif; other site 498214007166 Walker B; other site 498214007167 D-loop; other site 498214007168 H-loop/switch region; other site 498214007169 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214007170 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214007171 dimer interface [polypeptide binding]; other site 498214007172 phosphorylation site [posttranslational modification] 498214007173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214007174 ATP binding site [chemical binding]; other site 498214007175 Mg2+ binding site [ion binding]; other site 498214007176 G-X-G motif; other site 498214007177 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214007178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214007179 active site 498214007180 phosphorylation site [posttranslational modification] 498214007181 intermolecular recognition site; other site 498214007182 dimerization interface [polypeptide binding]; other site 498214007183 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214007184 DNA binding site [nucleotide binding] 498214007185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214007186 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 498214007187 active site 498214007188 catalytic site [active] 498214007189 substrate binding site [chemical binding]; other site 498214007190 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214007191 non-specific DNA binding site [nucleotide binding]; other site 498214007192 salt bridge; other site 498214007193 sequence-specific DNA binding site [nucleotide binding]; other site 498214007194 transglutaminase; Provisional; Region: tgl; PRK03187 498214007195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 498214007196 stage V sporulation protein K; Region: spore_V_K; TIGR02881 498214007197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214007198 Walker A motif; other site 498214007199 ATP binding site [chemical binding]; other site 498214007200 Walker B motif; other site 498214007201 arginine finger; other site 498214007202 stage V sporulation protein K; Region: spore_V_K; TIGR02881 498214007203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214007204 Walker A motif; other site 498214007205 ATP binding site [chemical binding]; other site 498214007206 Walker B motif; other site 498214007207 arginine finger; other site 498214007208 stage V sporulation protein K; Region: spore_V_K; TIGR02881 498214007209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214007210 Walker A motif; other site 498214007211 ATP binding site [chemical binding]; other site 498214007212 Walker B motif; other site 498214007213 arginine finger; other site 498214007214 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 498214007215 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498214007216 Spore germination protein; Region: Spore_permease; pfam03845 498214007217 Predicted membrane protein [Function unknown]; Region: COG2323 498214007218 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 498214007219 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 498214007220 active site 498214007221 NTP binding site [chemical binding]; other site 498214007222 metal binding triad [ion binding]; metal-binding site 498214007223 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 498214007224 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214007225 Zn2+ binding site [ion binding]; other site 498214007226 Mg2+ binding site [ion binding]; other site 498214007227 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 498214007228 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 498214007229 CAAX protease self-immunity; Region: Abi; pfam02517 498214007230 Src Homology 3 domain superfamily; Region: SH3; cl17036 498214007231 Predicted transcriptional regulators [Transcription]; Region: COG1695 498214007232 Transcriptional regulator PadR-like family; Region: PadR; cl17335 498214007233 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 498214007234 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214007235 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 498214007236 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214007237 dimer interface [polypeptide binding]; other site 498214007238 phosphorylation site [posttranslational modification] 498214007239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214007240 ATP binding site [chemical binding]; other site 498214007241 Mg2+ binding site [ion binding]; other site 498214007242 G-X-G motif; other site 498214007243 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214007244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214007245 active site 498214007246 phosphorylation site [posttranslational modification] 498214007247 intermolecular recognition site; other site 498214007248 dimerization interface [polypeptide binding]; other site 498214007249 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214007250 DNA binding site [nucleotide binding] 498214007251 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 498214007252 Transcription factor homologous to NACalpha-BTF3 [Transcription]; Region: EGD2; COG1308 498214007253 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 498214007254 Beta-lactamase; Region: Beta-lactamase; pfam00144 498214007255 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214007256 Walker A/P-loop; other site 498214007257 ATP binding site [chemical binding]; other site 498214007258 Q-loop/lid; other site 498214007259 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214007260 ABC transporter signature motif; other site 498214007261 Walker B; other site 498214007262 D-loop; other site 498214007263 H-loop/switch region; other site 498214007264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214007265 AAA domain; Region: AAA_21; pfam13304 498214007266 Walker A/P-loop; other site 498214007267 ATP binding site [chemical binding]; other site 498214007268 Q-loop/lid; other site 498214007269 ABC transporter signature motif; other site 498214007270 Walker B; other site 498214007271 D-loop; other site 498214007272 H-loop/switch region; other site 498214007273 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214007274 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214007275 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 498214007276 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 498214007277 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 498214007278 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498214007279 catalytic residue [active] 498214007280 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 498214007281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214007282 Walker A motif; other site 498214007283 ATP binding site [chemical binding]; other site 498214007284 Walker B motif; other site 498214007285 Glucose inhibited division protein A; Region: GIDA; pfam01134 498214007286 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 498214007287 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 498214007288 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 498214007289 tetramer interface [polypeptide binding]; other site 498214007290 active site 498214007291 Uncharacterized conserved protein [Function unknown]; Region: COG2155 498214007292 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 498214007293 dimerization domain swap beta strand [polypeptide binding]; other site 498214007294 regulatory protein interface [polypeptide binding]; other site 498214007295 active site 498214007296 regulatory phosphorylation site [posttranslational modification]; other site 498214007297 aspartate aminotransferase; Provisional; Region: PRK05764 498214007298 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498214007299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214007300 homodimer interface [polypeptide binding]; other site 498214007301 catalytic residue [active] 498214007302 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 498214007303 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 498214007304 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 498214007305 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 498214007306 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 498214007307 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214007308 Zn2+ binding site [ion binding]; other site 498214007309 Mg2+ binding site [ion binding]; other site 498214007310 recombinase A; Provisional; Region: recA; PRK09354 498214007311 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 498214007312 hexamer interface [polypeptide binding]; other site 498214007313 Walker A motif; other site 498214007314 ATP binding site [chemical binding]; other site 498214007315 Walker B motif; other site 498214007316 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 498214007317 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 498214007318 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 498214007319 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 498214007320 Tetraspanin family; Region: Tetraspannin; pfam00335 498214007321 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 498214007322 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 498214007323 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 498214007324 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 498214007325 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 498214007326 active site 498214007327 aspartate kinase I; Reviewed; Region: PRK08210 498214007328 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 498214007329 nucleotide binding site [chemical binding]; other site 498214007330 substrate binding site [chemical binding]; other site 498214007331 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 498214007332 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 498214007333 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 498214007334 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 498214007335 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 498214007336 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 498214007337 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 498214007338 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 498214007339 RNase E interface [polypeptide binding]; other site 498214007340 trimer interface [polypeptide binding]; other site 498214007341 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 498214007342 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 498214007343 RNase E interface [polypeptide binding]; other site 498214007344 trimer interface [polypeptide binding]; other site 498214007345 active site 498214007346 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 498214007347 putative nucleic acid binding region [nucleotide binding]; other site 498214007348 G-X-X-G motif; other site 498214007349 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 498214007350 RNA binding site [nucleotide binding]; other site 498214007351 domain interface; other site 498214007352 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 498214007353 16S/18S rRNA binding site [nucleotide binding]; other site 498214007354 S13e-L30e interaction site [polypeptide binding]; other site 498214007355 25S rRNA binding site [nucleotide binding]; other site 498214007356 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 498214007357 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 498214007358 active site 498214007359 Riboflavin kinase; Region: Flavokinase; pfam01687 498214007360 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 498214007361 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 498214007362 RNA binding site [nucleotide binding]; other site 498214007363 active site 498214007364 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 498214007365 DHH family; Region: DHH; pfam01368 498214007366 DHHA1 domain; Region: DHHA1; pfam02272 498214007367 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 498214007368 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 498214007369 translation initiation factor IF-2; Region: IF-2; TIGR00487 498214007370 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 498214007371 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 498214007372 G1 box; other site 498214007373 putative GEF interaction site [polypeptide binding]; other site 498214007374 GTP/Mg2+ binding site [chemical binding]; other site 498214007375 Switch I region; other site 498214007376 G2 box; other site 498214007377 G3 box; other site 498214007378 Switch II region; other site 498214007379 G4 box; other site 498214007380 G5 box; other site 498214007381 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 498214007382 Translation-initiation factor 2; Region: IF-2; pfam11987 498214007383 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 498214007384 ribosomal protein L7Ae family protein; Provisional; Region: PRK05583 498214007385 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 498214007386 putative RNA binding cleft [nucleotide binding]; other site 498214007387 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 498214007388 NusA N-terminal domain; Region: NusA_N; pfam08529 498214007389 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 498214007390 RNA binding site [nucleotide binding]; other site 498214007391 homodimer interface [polypeptide binding]; other site 498214007392 NusA-like KH domain; Region: KH_5; pfam13184 498214007393 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 498214007394 G-X-X-G motif; other site 498214007395 ribosome maturation protein RimP; Reviewed; Region: PRK00092 498214007396 Sm and related proteins; Region: Sm_like; cl00259 498214007397 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 498214007398 putative oligomer interface [polypeptide binding]; other site 498214007399 putative RNA binding site [nucleotide binding]; other site 498214007400 DNA polymerase III PolC; Validated; Region: polC; PRK00448 498214007401 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 498214007402 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 498214007403 generic binding surface II; other site 498214007404 generic binding surface I; other site 498214007405 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 498214007406 active site 498214007407 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 498214007408 active site 498214007409 catalytic site [active] 498214007410 substrate binding site [chemical binding]; other site 498214007411 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 498214007412 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 498214007413 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 498214007414 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 498214007415 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 498214007416 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 498214007417 active site 498214007418 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 498214007419 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 498214007420 putative substrate binding region [chemical binding]; other site 498214007421 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 498214007422 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 498214007423 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 498214007424 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 498214007425 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 498214007426 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 498214007427 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 498214007428 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 498214007429 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 498214007430 catalytic residue [active] 498214007431 putative FPP diphosphate binding site; other site 498214007432 putative FPP binding hydrophobic cleft; other site 498214007433 dimer interface [polypeptide binding]; other site 498214007434 putative IPP diphosphate binding site; other site 498214007435 ribosome recycling factor; Reviewed; Region: frr; PRK00083 498214007436 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 498214007437 hinge region; other site 498214007438 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 498214007439 putative nucleotide binding site [chemical binding]; other site 498214007440 uridine monophosphate binding site [chemical binding]; other site 498214007441 homohexameric interface [polypeptide binding]; other site 498214007442 elongation factor Ts; Provisional; Region: tsf; PRK09377 498214007443 UBA/TS-N domain; Region: UBA; pfam00627 498214007444 Elongation factor TS; Region: EF_TS; pfam00889 498214007445 Elongation factor TS; Region: EF_TS; pfam00889 498214007446 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 498214007447 rRNA interaction site [nucleotide binding]; other site 498214007448 S8 interaction site; other site 498214007449 putative laminin-1 binding site; other site 498214007450 transcriptional repressor CodY; Validated; Region: PRK04158 498214007451 CodY GAF-like domain; Region: CodY; pfam06018 498214007452 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 498214007453 DNA topoisomerase I; Validated; Region: PRK05582 498214007454 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 498214007455 active site 498214007456 interdomain interaction site; other site 498214007457 putative metal-binding site [ion binding]; other site 498214007458 nucleotide binding site [chemical binding]; other site 498214007459 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 498214007460 domain I; other site 498214007461 DNA binding groove [nucleotide binding] 498214007462 phosphate binding site [ion binding]; other site 498214007463 domain II; other site 498214007464 domain III; other site 498214007465 nucleotide binding site [chemical binding]; other site 498214007466 catalytic site [active] 498214007467 domain IV; other site 498214007468 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 498214007469 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 498214007470 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 498214007471 DNA protecting protein DprA; Region: dprA; TIGR00732 498214007472 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 498214007473 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 498214007474 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 498214007475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214007476 Walker A motif; other site 498214007477 ATP binding site [chemical binding]; other site 498214007478 Walker B motif; other site 498214007479 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 498214007480 hypothetical protein; Reviewed; Region: PRK12497 498214007481 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 498214007482 RNA/DNA hybrid binding site [nucleotide binding]; other site 498214007483 active site 498214007484 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 498214007485 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 498214007486 GTP/Mg2+ binding site [chemical binding]; other site 498214007487 G4 box; other site 498214007488 G5 box; other site 498214007489 G1 box; other site 498214007490 Switch I region; other site 498214007491 G2 box; other site 498214007492 G3 box; other site 498214007493 Switch II region; other site 498214007494 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 498214007495 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 498214007496 Catalytic site [active] 498214007497 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 498214007498 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 498214007499 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 498214007500 RimM N-terminal domain; Region: RimM; pfam01782 498214007501 PRC-barrel domain; Region: PRC; pfam05239 498214007502 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 498214007503 hypothetical protein; Provisional; Region: PRK00468 498214007504 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 498214007505 signal recognition particle protein; Provisional; Region: PRK10867 498214007506 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 498214007507 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 498214007508 P loop; other site 498214007509 GTP binding site [chemical binding]; other site 498214007510 Signal peptide binding domain; Region: SRP_SPB; pfam02978 498214007511 putative DNA-binding protein; Validated; Region: PRK00118 498214007512 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 498214007513 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 498214007514 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 498214007515 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498214007516 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 498214007517 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 498214007518 Walker A/P-loop; other site 498214007519 ATP binding site [chemical binding]; other site 498214007520 Q-loop/lid; other site 498214007521 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 498214007522 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 498214007523 Q-loop/lid; other site 498214007524 ABC transporter signature motif; other site 498214007525 Walker B; other site 498214007526 D-loop; other site 498214007527 H-loop/switch region; other site 498214007528 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 498214007529 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214007530 FeS/SAM binding site; other site 498214007531 ribonuclease III; Reviewed; Region: rnc; PRK00102 498214007532 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 498214007533 dimerization interface [polypeptide binding]; other site 498214007534 active site 498214007535 metal binding site [ion binding]; metal-binding site 498214007536 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 498214007537 dsRNA binding site [nucleotide binding]; other site 498214007538 acyl carrier protein; Provisional; Region: acpP; PRK00982 498214007539 putative phosphate acyltransferase; Provisional; Region: PRK05331 498214007540 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 498214007541 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 498214007542 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 498214007543 propionate/acetate kinase; Provisional; Region: PRK12379 498214007544 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 498214007545 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 498214007546 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 498214007547 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 498214007548 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 498214007549 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 498214007550 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 498214007551 Cache domain; Region: Cache_1; pfam02743 498214007552 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214007553 dimerization interface [polypeptide binding]; other site 498214007554 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498214007555 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214007556 dimer interface [polypeptide binding]; other site 498214007557 putative CheW interface [polypeptide binding]; other site 498214007558 Uncharacterized conserved protein [Function unknown]; Region: COG1915 498214007559 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528 498214007560 Uncharacterized conserved protein [Function unknown]; Region: COG1915 498214007561 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 498214007562 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 498214007563 proline racemase; Provisional; Region: PRK13969 498214007564 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 498214007565 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 498214007566 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 498214007567 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 498214007568 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 498214007569 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 498214007570 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 498214007571 SLBB domain; Region: SLBB; pfam10531 498214007572 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 498214007573 SLBB domain; Region: SLBB; pfam10531 498214007574 Predicted permease; Region: DUF318; cl17795 498214007575 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 498214007576 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 498214007577 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 498214007578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498214007579 putative active site [active] 498214007580 heme pocket [chemical binding]; other site 498214007581 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214007582 Walker A motif; other site 498214007583 ATP binding site [chemical binding]; other site 498214007584 Walker B motif; other site 498214007585 arginine finger; other site 498214007586 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 498214007587 hypothetical protein; Provisional; Region: PRK13670 498214007588 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 498214007589 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 498214007590 Nucleoside recognition; Region: Gate; pfam07670 498214007591 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 498214007592 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 498214007593 active site 498214007594 (T/H)XGH motif; other site 498214007595 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 498214007596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214007597 S-adenosylmethionine binding site [chemical binding]; other site 498214007598 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 498214007599 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 498214007600 ssDNA binding site; other site 498214007601 generic binding surface II; other site 498214007602 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498214007603 ATP binding site [chemical binding]; other site 498214007604 putative Mg++ binding site [ion binding]; other site 498214007605 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498214007606 nucleotide binding region [chemical binding]; other site 498214007607 ATP-binding site [chemical binding]; other site 498214007608 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 498214007609 DAK2 domain; Region: Dak2; pfam02734 498214007610 Asp23 family; Region: Asp23; pfam03780 498214007611 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 498214007612 Thiamine pyrophosphokinase; Region: TPK; cd07995 498214007613 active site 498214007614 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 498214007615 dimerization interface [polypeptide binding]; other site 498214007616 thiamine binding site [chemical binding]; other site 498214007617 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 498214007618 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 498214007619 substrate binding site [chemical binding]; other site 498214007620 hexamer interface [polypeptide binding]; other site 498214007621 metal binding site [ion binding]; metal-binding site 498214007622 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 498214007623 GTPase RsgA; Reviewed; Region: PRK00098 498214007624 RNA binding site [nucleotide binding]; other site 498214007625 homodimer interface [polypeptide binding]; other site 498214007626 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 498214007627 GTPase/Zn-binding domain interface [polypeptide binding]; other site 498214007628 GTP/Mg2+ binding site [chemical binding]; other site 498214007629 G4 box; other site 498214007630 G5 box; other site 498214007631 G1 box; other site 498214007632 Switch I region; other site 498214007633 G2 box; other site 498214007634 G3 box; other site 498214007635 Switch II region; other site 498214007636 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 498214007637 Catalytic domain of Protein Kinases; Region: PKc; cd00180 498214007638 active site 498214007639 ATP binding site [chemical binding]; other site 498214007640 substrate binding site [chemical binding]; other site 498214007641 activation loop (A-loop); other site 498214007642 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 498214007643 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 498214007644 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 498214007645 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 498214007646 active site 498214007647 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 498214007648 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214007649 FeS/SAM binding site; other site 498214007650 16S rRNA methyltransferase B; Provisional; Region: PRK14902 498214007651 NusB family; Region: NusB; pfam01029 498214007652 putative RNA binding site [nucleotide binding]; other site 498214007653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214007654 S-adenosylmethionine binding site [chemical binding]; other site 498214007655 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 498214007656 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 498214007657 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 498214007658 putative active site [active] 498214007659 substrate binding site [chemical binding]; other site 498214007660 putative cosubstrate binding site; other site 498214007661 catalytic site [active] 498214007662 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 498214007663 substrate binding site [chemical binding]; other site 498214007664 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 498214007665 active site 498214007666 catalytic residues [active] 498214007667 metal binding site [ion binding]; metal-binding site 498214007668 primosome assembly protein PriA; Validated; Region: PRK05580 498214007669 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498214007670 ATP binding site [chemical binding]; other site 498214007671 putative Mg++ binding site [ion binding]; other site 498214007672 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498214007673 nucleotide binding region [chemical binding]; other site 498214007674 ATP-binding site [chemical binding]; other site 498214007675 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 498214007676 Flavoprotein; Region: Flavoprotein; pfam02441 498214007677 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 498214007678 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 498214007679 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 498214007680 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 498214007681 catalytic site [active] 498214007682 G-X2-G-X-G-K; other site 498214007683 hypothetical protein; Provisional; Region: PRK04323 498214007684 hypothetical protein; Provisional; Region: PRK11820 498214007685 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 498214007686 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 498214007687 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 498214007688 active site 498214007689 homotetramer interface [polypeptide binding]; other site 498214007690 homodimer interface [polypeptide binding]; other site 498214007691 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 498214007692 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 498214007693 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 498214007694 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 498214007695 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 498214007696 GTP-binding protein Der; Reviewed; Region: PRK00093 498214007697 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 498214007698 G1 box; other site 498214007699 GTP/Mg2+ binding site [chemical binding]; other site 498214007700 Switch I region; other site 498214007701 G2 box; other site 498214007702 Switch II region; other site 498214007703 G3 box; other site 498214007704 G4 box; other site 498214007705 G5 box; other site 498214007706 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 498214007707 G1 box; other site 498214007708 GTP/Mg2+ binding site [chemical binding]; other site 498214007709 Switch I region; other site 498214007710 G2 box; other site 498214007711 G3 box; other site 498214007712 Switch II region; other site 498214007713 G4 box; other site 498214007714 G5 box; other site 498214007715 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 498214007716 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 498214007717 Protein of unknown function (DUF512); Region: DUF512; pfam04459 498214007718 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 498214007719 PhoU domain; Region: PhoU; pfam01895 498214007720 PhoU domain; Region: PhoU; pfam01895 498214007721 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 498214007722 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 498214007723 Walker A/P-loop; other site 498214007724 ATP binding site [chemical binding]; other site 498214007725 Q-loop/lid; other site 498214007726 ABC transporter signature motif; other site 498214007727 Walker B; other site 498214007728 D-loop; other site 498214007729 H-loop/switch region; other site 498214007730 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 498214007731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214007732 dimer interface [polypeptide binding]; other site 498214007733 conserved gate region; other site 498214007734 putative PBP binding loops; other site 498214007735 ABC-ATPase subunit interface; other site 498214007736 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 498214007737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214007738 dimer interface [polypeptide binding]; other site 498214007739 conserved gate region; other site 498214007740 putative PBP binding loops; other site 498214007741 ABC-ATPase subunit interface; other site 498214007742 PBP superfamily domain; Region: PBP_like_2; cl17296 498214007743 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214007744 dimerization interface [polypeptide binding]; other site 498214007745 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 498214007746 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498214007747 putative active site [active] 498214007748 heme pocket [chemical binding]; other site 498214007749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214007750 dimer interface [polypeptide binding]; other site 498214007751 phosphorylation site [posttranslational modification] 498214007752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214007753 ATP binding site [chemical binding]; other site 498214007754 Mg2+ binding site [ion binding]; other site 498214007755 G-X-G motif; other site 498214007756 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214007757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214007758 active site 498214007759 phosphorylation site [posttranslational modification] 498214007760 intermolecular recognition site; other site 498214007761 dimerization interface [polypeptide binding]; other site 498214007762 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214007763 DNA binding site [nucleotide binding] 498214007764 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 498214007765 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 498214007766 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 498214007767 ATP cone domain; Region: ATP-cone; pfam03477 498214007768 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 498214007769 sporulation sigma factor SigG; Reviewed; Region: PRK08215 498214007770 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498214007771 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 498214007772 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498214007773 DNA binding residues [nucleotide binding] 498214007774 sporulation sigma factor SigE; Reviewed; Region: PRK08301 498214007775 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498214007776 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498214007777 DNA binding residues [nucleotide binding] 498214007778 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 498214007779 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 498214007780 cell division protein FtsZ; Validated; Region: PRK09330 498214007781 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 498214007782 nucleotide binding site [chemical binding]; other site 498214007783 SulA interaction site; other site 498214007784 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 498214007785 Cell division protein FtsA; Region: FtsA; smart00842 498214007786 Cell division protein FtsA; Region: FtsA; pfam14450 498214007787 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 498214007788 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 498214007789 DXD motif; other site 498214007790 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 498214007791 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 498214007792 Walker A motif; other site 498214007793 ATP binding site [chemical binding]; other site 498214007794 Walker B motif; other site 498214007795 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 498214007796 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 498214007797 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 498214007798 shikimate binding site; other site 498214007799 NAD(P) binding site [chemical binding]; other site 498214007800 sporulation sigma factor SigK; Reviewed; Region: PRK05803 498214007801 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498214007802 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498214007803 DNA binding residues [nucleotide binding] 498214007804 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 498214007805 conserved domain; Region: TIGR02271 498214007806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214007807 Coenzyme A binding pocket [chemical binding]; other site 498214007808 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 498214007809 RecT family; Region: RecT; pfam03837 498214007810 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 498214007811 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 498214007812 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 498214007813 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 498214007814 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 498214007815 Sugar specificity; other site 498214007816 Pyrimidine base specificity; other site 498214007817 ATP-binding site [chemical binding]; other site 498214007818 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 498214007819 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 498214007820 Peptidase family U32; Region: Peptidase_U32; pfam01136 498214007821 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 498214007822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214007823 S-adenosylmethionine binding site [chemical binding]; other site 498214007824 YceG-like family; Region: YceG; pfam02618 498214007825 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 498214007826 dimerization interface [polypeptide binding]; other site 498214007827 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 498214007828 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 498214007829 G1 box; other site 498214007830 putative GEF interaction site [polypeptide binding]; other site 498214007831 GTP/Mg2+ binding site [chemical binding]; other site 498214007832 Switch I region; other site 498214007833 G2 box; other site 498214007834 G3 box; other site 498214007835 Switch II region; other site 498214007836 G4 box; other site 498214007837 G5 box; other site 498214007838 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 498214007839 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 498214007840 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 498214007841 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498214007842 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 498214007843 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 498214007844 metal binding site 2 [ion binding]; metal-binding site 498214007845 putative DNA binding helix; other site 498214007846 metal binding site 1 [ion binding]; metal-binding site 498214007847 dimer interface [polypeptide binding]; other site 498214007848 structural Zn2+ binding site [ion binding]; other site 498214007849 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 498214007850 hypothetical protein; Provisional; Region: PRK05473 498214007851 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 498214007852 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 498214007853 motif 1; other site 498214007854 active site 498214007855 motif 2; other site 498214007856 motif 3; other site 498214007857 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 498214007858 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 498214007859 Domain of unknown function DUF20; Region: UPF0118; pfam01594 498214007860 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 498214007861 PRC-barrel domain; Region: PRC; pfam05239 498214007862 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 498214007863 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 498214007864 trimerization site [polypeptide binding]; other site 498214007865 active site 498214007866 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 498214007867 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 498214007868 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498214007869 catalytic residue [active] 498214007870 Transcriptional regulator; Region: Rrf2; cl17282 498214007871 Rrf2 family protein; Region: rrf2_super; TIGR00738 498214007872 recombination factor protein RarA; Reviewed; Region: PRK13342 498214007873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214007874 Walker A motif; other site 498214007875 ATP binding site [chemical binding]; other site 498214007876 Walker B motif; other site 498214007877 arginine finger; other site 498214007878 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 498214007879 histidinol-phosphatase; Provisional; Region: PRK05588 498214007880 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 498214007881 active site 498214007882 Predicted permeases [General function prediction only]; Region: COG0679 498214007883 EDD domain protein, DegV family; Region: DegV; TIGR00762 498214007884 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 498214007885 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 498214007886 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 498214007887 CPxP motif; other site 498214007888 DsrE/DsrF-like family; Region: DrsE; pfam02635 498214007889 ornithine cyclodeaminase; Validated; Region: PRK08618 498214007890 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 498214007891 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 498214007892 amino acid carrier protein; Region: agcS; TIGR00835 498214007893 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 498214007894 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 498214007895 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 498214007896 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 498214007897 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 498214007898 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 498214007899 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 498214007900 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 498214007901 dimerization interface [polypeptide binding]; other site 498214007902 ATP binding site [chemical binding]; other site 498214007903 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 498214007904 dimerization interface [polypeptide binding]; other site 498214007905 ATP binding site [chemical binding]; other site 498214007906 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 498214007907 putative active site [active] 498214007908 catalytic triad [active] 498214007909 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 498214007910 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 498214007911 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 498214007912 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 498214007913 Phosphopantetheine attachment site; Region: PP-binding; cl09936 498214007914 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 498214007915 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 498214007916 active site 498214007917 AMP binding site [chemical binding]; other site 498214007918 acyl-activating enzyme (AAE) consensus motif; other site 498214007919 CoA binding site [chemical binding]; other site 498214007920 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 498214007921 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 498214007922 dimer interface [polypeptide binding]; other site 498214007923 active site 498214007924 CoA binding pocket [chemical binding]; other site 498214007925 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 498214007926 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 498214007927 AMP-binding enzyme; Region: AMP-binding; pfam00501 498214007928 acyl-activating enzyme (AAE) consensus motif; other site 498214007929 AMP binding site [chemical binding]; other site 498214007930 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 498214007931 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 498214007932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214007933 Coenzyme A binding pocket [chemical binding]; other site 498214007934 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 498214007935 Ligand Binding Site [chemical binding]; other site 498214007936 hypothetical protein; Validated; Region: PRK07080 498214007937 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 498214007938 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 498214007939 ornithine carbamoyltransferase; Provisional; Region: PRK04284 498214007940 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 498214007941 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 498214007942 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 498214007943 carbamate kinase; Reviewed; Region: PRK12686 498214007944 putative substrate binding site [chemical binding]; other site 498214007945 nucleotide binding site [chemical binding]; other site 498214007946 nucleotide binding site [chemical binding]; other site 498214007947 homodimer interface [polypeptide binding]; other site 498214007948 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 498214007949 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 498214007950 dimer interface [polypeptide binding]; other site 498214007951 active site 498214007952 glycine-pyridoxal phosphate binding site [chemical binding]; other site 498214007953 folate binding site [chemical binding]; other site 498214007954 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 498214007955 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 498214007956 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 498214007957 putative homodimer interface [polypeptide binding]; other site 498214007958 putative homotetramer interface [polypeptide binding]; other site 498214007959 putative allosteric switch controlling residues; other site 498214007960 putative metal binding site [ion binding]; other site 498214007961 putative homodimer-homodimer interface [polypeptide binding]; other site 498214007962 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498214007963 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 498214007964 active site 498214007965 motif I; other site 498214007966 motif II; other site 498214007967 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 498214007968 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 498214007969 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 498214007970 active site 498214007971 nucleotide binding site [chemical binding]; other site 498214007972 HIGH motif; other site 498214007973 KMSKS motif; other site 498214007974 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 498214007975 NAD(P) binding site [chemical binding]; other site 498214007976 LDH/MDH dimer interface [polypeptide binding]; other site 498214007977 substrate binding site [chemical binding]; other site 498214007978 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 498214007979 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 498214007980 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 498214007981 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 498214007982 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 498214007983 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 498214007984 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 498214007985 oligomer interface [polypeptide binding]; other site 498214007986 putative active site [active] 498214007987 metal binding site [ion binding]; metal-binding site 498214007988 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 498214007989 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 498214007990 oligomer interface [polypeptide binding]; other site 498214007991 metal binding site [ion binding]; metal-binding site 498214007992 metal binding site [ion binding]; metal-binding site 498214007993 putative Cl binding site [ion binding]; other site 498214007994 aspartate ring; other site 498214007995 basic sphincter; other site 498214007996 hydrophobic gate; other site 498214007997 periplasmic entrance; other site 498214007998 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 498214007999 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 498214008000 HPr kinase/phosphorylase; Provisional; Region: PRK05428 498214008001 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 498214008002 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 498214008003 Hpr binding site; other site 498214008004 active site 498214008005 homohexamer subunit interaction site [polypeptide binding]; other site 498214008006 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 498214008007 Uncharacterized conserved protein [Function unknown]; Region: COG0398 498214008008 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 498214008009 Uncharacterized conserved protein [Function unknown]; Region: COG0398 498214008010 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 498214008011 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 498214008012 Cysteine-rich domain; Region: CCG; pfam02754 498214008013 Cysteine-rich domain; Region: CCG; pfam02754 498214008014 Phosphotransferase enzyme family; Region: APH; pfam01636 498214008015 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 498214008016 active site 498214008017 ATP binding site [chemical binding]; other site 498214008018 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 498214008019 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 498214008020 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 498214008021 Probable Catalytic site; other site 498214008022 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 498214008023 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 498214008024 putative active site [active] 498214008025 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 498214008026 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 498214008027 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498214008028 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 498214008029 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 498214008030 active site 498214008031 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 498214008032 active site 498214008033 catalytic residues [active] 498214008034 metal binding site [ion binding]; metal-binding site 498214008035 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 498214008036 V-type ATP synthase subunit B; Provisional; Region: PRK04196 498214008037 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 498214008038 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 498214008039 Walker A motif homologous position; other site 498214008040 Walker B motif; other site 498214008041 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 498214008042 V-type ATP synthase subunit A; Provisional; Region: PRK04192 498214008043 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 498214008044 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 498214008045 Walker A motif/ATP binding site; other site 498214008046 Walker B motif; other site 498214008047 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 498214008048 V-type ATP synthase subunit F; Provisional; Region: PRK01395 498214008049 V-type ATP synthase subunit C; Provisional; Region: PRK01198 498214008050 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 498214008051 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 498214008052 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 498214008053 V-type ATP synthase subunit K; Validated; Region: PRK06558 498214008054 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 498214008055 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 498214008056 V-type ATP synthase subunit I; Validated; Region: PRK05771 498214008057 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 498214008058 V-type ATP synthase subunit H; Validated; Region: PRK08404 498214008059 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 498214008060 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 498214008061 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 498214008062 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 498214008063 Zn binding site [ion binding]; other site 498214008064 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 498214008065 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 498214008066 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 498214008067 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 498214008068 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 498214008069 Soluble P-type ATPase [General function prediction only]; Region: COG4087 498214008070 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 498214008071 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 498214008072 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 498214008073 DRTGG domain; Region: DRTGG; pfam07085 498214008074 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 498214008075 DHH family; Region: DHH; pfam01368 498214008076 DHHA2 domain; Region: DHHA2; pfam02833 498214008077 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 498214008078 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 498214008079 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 498214008080 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 498214008081 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 498214008082 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 498214008083 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 498214008084 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498214008085 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 498214008086 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498214008087 DNA binding residues [nucleotide binding] 498214008088 Flagellar protein YcgR; Region: YcgR_2; pfam12945 498214008089 PilZ domain; Region: PilZ; pfam07238 498214008090 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 498214008091 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 498214008092 P-loop; other site 498214008093 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 498214008094 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498214008095 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 498214008096 FHIPEP family; Region: FHIPEP; pfam00771 498214008097 bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772 498214008098 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 498214008099 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 498214008100 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 498214008101 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 498214008102 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 498214008103 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 498214008104 flagellar motor protein MotS; Reviewed; Region: PRK06925 498214008105 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 498214008106 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 498214008107 ligand binding site [chemical binding]; other site 498214008108 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 498214008109 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 498214008110 Flagellar protein (FlbD); Region: FlbD; pfam06289 498214008111 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 498214008112 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 498214008113 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 498214008114 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 498214008115 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 498214008116 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 498214008117 Flagellar FliJ protein; Region: FliJ; pfam02050 498214008118 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 498214008119 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 498214008120 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 498214008121 Walker A motif/ATP binding site; other site 498214008122 Walker B motif; other site 498214008123 Flagellar assembly protein FliH; Region: FliH; pfam02108 498214008124 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 498214008125 FliG C-terminal domain; Region: FliG_C; pfam01706 498214008126 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 498214008127 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 498214008128 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 498214008129 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 498214008130 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623 498214008131 flagellin; Provisional; Region: PRK12804 498214008132 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 498214008133 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 498214008134 argininosuccinate lyase; Provisional; Region: PRK00855 498214008135 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 498214008136 active sites [active] 498214008137 tetramer interface [polypeptide binding]; other site 498214008138 argininosuccinate synthase; Provisional; Region: PRK13820 498214008139 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 498214008140 ANP binding site [chemical binding]; other site 498214008141 Substrate Binding Site II [chemical binding]; other site 498214008142 Substrate Binding Site I [chemical binding]; other site 498214008143 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 498214008144 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 498214008145 putative active site [active] 498214008146 catalytic site [active] 498214008147 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 498214008148 putative active site [active] 498214008149 catalytic site [active] 498214008150 Predicted membrane protein [Function unknown]; Region: COG4129 498214008151 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 498214008152 Predicted integral membrane protein [Function unknown]; Region: COG5652 498214008153 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 498214008154 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 498214008155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 498214008156 NAD(P) binding site [chemical binding]; other site 498214008157 active site 498214008158 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 498214008159 NeuB family; Region: NeuB; pfam03102 498214008160 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 498214008161 NeuB binding interface [polypeptide binding]; other site 498214008162 putative substrate binding site [chemical binding]; other site 498214008163 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 498214008164 ligand binding site; other site 498214008165 tetramer interface; other site 498214008166 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 498214008167 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 498214008168 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 498214008169 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 498214008170 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 498214008171 UDP-galactopyranose mutase; Region: GLF; pfam03275 498214008172 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 498214008173 Bacterial sugar transferase; Region: Bac_transf; pfam02397 498214008174 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 498214008175 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 498214008176 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 498214008177 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 498214008178 Chain length determinant protein; Region: Wzz; cl15801 498214008179 Transcriptional regulator [Transcription]; Region: LytR; COG1316 498214008180 Putative motility protein; Region: YjfB_motility; pfam14070 498214008181 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214008182 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498214008183 dimer interface [polypeptide binding]; other site 498214008184 putative CheW interface [polypeptide binding]; other site 498214008185 flagellin; Provisional; Region: PRK12804 498214008186 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 498214008187 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 498214008188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 498214008189 binding surface 498214008190 TPR motif; other site 498214008191 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 498214008192 catalytic triad [active] 498214008193 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 498214008194 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 498214008195 active site 498214008196 catalytic triad [active] 498214008197 oxyanion hole [active] 498214008198 Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171 498214008199 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 498214008200 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 498214008201 active site 498214008202 Tetratricopeptide repeat; Region: TPR_12; pfam13424 498214008203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 498214008204 binding surface 498214008205 TPR motif; other site 498214008206 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 498214008207 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 498214008208 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 498214008209 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 498214008210 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 498214008211 putative active site [active] 498214008212 putative catalytic site [active] 498214008213 CoA binding domain; Region: CoA_binding; cl17356 498214008214 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 498214008215 Methyltransferase domain; Region: Methyltransf_12; pfam08242 498214008216 S-adenosylmethionine binding site [chemical binding]; other site 498214008217 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 498214008218 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 498214008219 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 498214008220 inhibitor-cofactor binding pocket; inhibition site 498214008221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214008222 catalytic residue [active] 498214008223 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 498214008224 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 498214008225 NAD binding site [chemical binding]; other site 498214008226 substrate binding site [chemical binding]; other site 498214008227 active site 498214008228 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 498214008229 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 498214008230 active site 498214008231 substrate binding site [chemical binding]; other site 498214008232 cosubstrate binding site; other site 498214008233 catalytic site [active] 498214008234 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 498214008235 active site 498214008236 hexamer interface [polypeptide binding]; other site 498214008237 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 498214008238 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 498214008239 active site 498214008240 homodimer interface [polypeptide binding]; other site 498214008241 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 498214008242 NeuB family; Region: NeuB; pfam03102 498214008243 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 498214008244 NeuB binding interface [polypeptide binding]; other site 498214008245 putative substrate binding site [chemical binding]; other site 498214008246 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 498214008247 ligand binding site; other site 498214008248 tetramer interface; other site 498214008249 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214008250 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 498214008251 FeS/SAM binding site; other site 498214008252 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 498214008253 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 498214008254 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 498214008255 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 498214008256 Substrate binding site; other site 498214008257 metal-binding site 498214008258 pseudaminic acid synthase; Region: PseI; TIGR03586 498214008259 NeuB family; Region: NeuB; pfam03102 498214008260 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 498214008261 NeuB binding interface [polypeptide binding]; other site 498214008262 putative substrate binding site [chemical binding]; other site 498214008263 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 498214008264 ligand binding site; other site 498214008265 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 498214008266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498214008267 motif II; other site 498214008268 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 498214008269 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 498214008270 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 498214008271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 498214008272 NAD(P) binding site [chemical binding]; other site 498214008273 active site 498214008274 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 498214008275 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 498214008276 NAD(P) binding site [chemical binding]; other site 498214008277 homodimer interface [polypeptide binding]; other site 498214008278 substrate binding site [chemical binding]; other site 498214008279 active site 498214008280 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 498214008281 putative metal binding site; other site 498214008282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 498214008283 TPR motif; other site 498214008284 binding surface 498214008285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 498214008286 binding surface 498214008287 TPR motif; other site 498214008288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 498214008289 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 498214008290 putative metal binding site; other site 498214008291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 498214008292 binding surface 498214008293 TPR motif; other site 498214008294 Tetratricopeptide repeat; Region: TPR_16; pfam13432 498214008295 flagellin; Provisional; Region: PRK12804 498214008296 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 498214008297 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 498214008298 flagellin; Provisional; Region: PRK12804 498214008299 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 498214008300 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 498214008301 Flagellar protein FliT; Region: FliT; pfam05400 498214008302 flagellar capping protein; Validated; Region: fliD; PRK07737 498214008303 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 498214008304 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 498214008305 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 498214008306 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 498214008307 FlaG protein; Region: FlaG; pfam03646 498214008308 carbon storage regulator; Provisional; Region: PRK01712 498214008309 flagellar assembly protein FliW; Provisional; Region: PRK13285 498214008310 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 498214008311 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 498214008312 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 498214008313 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 498214008314 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 498214008315 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 498214008316 FlgN protein; Region: FlgN; pfam05130 498214008317 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 498214008318 flagellar motor switch protein; Validated; Region: PRK08119 498214008319 CheC-like family; Region: CheC; pfam04509 498214008320 CheC-like family; Region: CheC; pfam04509 498214008321 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 498214008322 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 498214008323 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 498214008324 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 498214008325 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 498214008326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214008327 active site 498214008328 phosphorylation site [posttranslational modification] 498214008329 intermolecular recognition site; other site 498214008330 dimerization interface [polypeptide binding]; other site 498214008331 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 498214008332 CheC-like family; Region: CheC; pfam04509 498214008333 CheC-like family; Region: CheC; pfam04509 498214008334 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 498214008335 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 498214008336 putative binding surface; other site 498214008337 active site 498214008338 P2 response regulator binding domain; Region: P2; pfam07194 498214008339 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 498214008340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214008341 ATP binding site [chemical binding]; other site 498214008342 Mg2+ binding site [ion binding]; other site 498214008343 G-X-G motif; other site 498214008344 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 498214008345 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 498214008346 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 498214008347 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 498214008348 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 498214008349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214008350 active site 498214008351 phosphorylation site [posttranslational modification] 498214008352 intermolecular recognition site; other site 498214008353 dimerization interface [polypeptide binding]; other site 498214008354 CheB methylesterase; Region: CheB_methylest; pfam01339 498214008355 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13490 498214008356 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 498214008357 Protein of unknown function (DUF342); Region: DUF342; pfam03961 498214008358 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 498214008359 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 498214008360 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 498214008361 active site turn [active] 498214008362 phosphorylation site [posttranslational modification] 498214008363 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 498214008364 HPr interaction site; other site 498214008365 glycerol kinase (GK) interaction site [polypeptide binding]; other site 498214008366 active site 498214008367 phosphorylation site [posttranslational modification] 498214008368 transcriptional antiterminator BglG; Provisional; Region: PRK09772 498214008369 CAT RNA binding domain; Region: CAT_RBD; smart01061 498214008370 PRD domain; Region: PRD; pfam00874 498214008371 PRD domain; Region: PRD; pfam00874 498214008372 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 498214008373 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 498214008374 homodimer interface [polypeptide binding]; other site 498214008375 substrate-cofactor binding pocket; other site 498214008376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214008377 catalytic residue [active] 498214008378 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 498214008379 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498214008380 motif II; other site 498214008381 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 498214008382 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 498214008383 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 498214008384 dimer interface [polypeptide binding]; other site 498214008385 PYR/PP interface [polypeptide binding]; other site 498214008386 TPP binding site [chemical binding]; other site 498214008387 substrate binding site [chemical binding]; other site 498214008388 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 498214008389 Domain of unknown function; Region: EKR; smart00890 498214008390 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498214008391 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 498214008392 TPP-binding site [chemical binding]; other site 498214008393 dimer interface [polypeptide binding]; other site 498214008394 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 498214008395 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 498214008396 active site 498214008397 homodimer interface [polypeptide binding]; other site 498214008398 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 498214008399 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214008400 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214008401 dimer interface [polypeptide binding]; other site 498214008402 phosphorylation site [posttranslational modification] 498214008403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214008404 ATP binding site [chemical binding]; other site 498214008405 Mg2+ binding site [ion binding]; other site 498214008406 G-X-G motif; other site 498214008407 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 498214008408 DHH family; Region: DHH; pfam01368 498214008409 DHHA1 domain; Region: DHHA1; pfam02272 498214008410 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 498214008411 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 498214008412 AP (apurinic/apyrimidinic) site pocket; other site 498214008413 DNA interaction; other site 498214008414 Metal-binding active site; metal-binding site 498214008415 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 498214008416 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 498214008417 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 498214008418 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 498214008419 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 498214008420 GtrA-like protein; Region: GtrA; pfam04138 498214008421 DJ-1 family protein; Region: not_thiJ; TIGR01383 498214008422 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 498214008423 conserved cys residue [active] 498214008424 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 498214008425 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 498214008426 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 498214008427 CAP-like domain; other site 498214008428 active site 498214008429 primary dimer interface [polypeptide binding]; other site 498214008430 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 498214008431 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 498214008432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214008433 ATP binding site [chemical binding]; other site 498214008434 Mg2+ binding site [ion binding]; other site 498214008435 G-X-G motif; other site 498214008436 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 498214008437 anchoring element; other site 498214008438 dimer interface [polypeptide binding]; other site 498214008439 ATP binding site [chemical binding]; other site 498214008440 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 498214008441 active site 498214008442 metal binding site [ion binding]; metal-binding site 498214008443 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 498214008444 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 498214008445 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 498214008446 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 498214008447 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 498214008448 NodB motif; other site 498214008449 active site 498214008450 catalytic site [active] 498214008451 Zn binding site [ion binding]; other site 498214008452 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 498214008453 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 498214008454 NAD binding site [chemical binding]; other site 498214008455 homodimer interface [polypeptide binding]; other site 498214008456 active site 498214008457 substrate binding site [chemical binding]; other site 498214008458 flavodoxin; Provisional; Region: PRK05568 498214008459 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 498214008460 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 498214008461 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 498214008462 Cupin domain; Region: Cupin_2; cl17218 498214008463 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 498214008464 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214008465 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 498214008466 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 498214008467 putative dimer interface [polypeptide binding]; other site 498214008468 catalytic triad [active] 498214008469 glycerol kinase; Provisional; Region: glpK; PRK00047 498214008470 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 498214008471 N- and C-terminal domain interface [polypeptide binding]; other site 498214008472 active site 498214008473 MgATP binding site [chemical binding]; other site 498214008474 catalytic site [active] 498214008475 metal binding site [ion binding]; metal-binding site 498214008476 glycerol binding site [chemical binding]; other site 498214008477 homotetramer interface [polypeptide binding]; other site 498214008478 homodimer interface [polypeptide binding]; other site 498214008479 FBP binding site [chemical binding]; other site 498214008480 protein IIAGlc interface [polypeptide binding]; other site 498214008481 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 498214008482 amphipathic channel; other site 498214008483 Asn-Pro-Ala signature motifs; other site 498214008484 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 498214008485 VanZ like family; Region: VanZ; pfam04892 498214008486 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 498214008487 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 498214008488 Walker A/P-loop; other site 498214008489 ATP binding site [chemical binding]; other site 498214008490 Q-loop/lid; other site 498214008491 ABC transporter signature motif; other site 498214008492 Walker B; other site 498214008493 D-loop; other site 498214008494 H-loop/switch region; other site 498214008495 Predicted transcriptional regulators [Transcription]; Region: COG1725 498214008496 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214008497 DNA-binding site [nucleotide binding]; DNA binding site 498214008498 VanZ like family; Region: VanZ; cl01971 498214008499 hybrid cluster protein; Provisional; Region: PRK05290 498214008500 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498214008501 ACS interaction site; other site 498214008502 CODH interaction site; other site 498214008503 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 498214008504 hybrid metal cluster; other site 498214008505 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 498214008506 dimerization interface [polypeptide binding]; other site 498214008507 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 498214008508 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 498214008509 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498214008510 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214008511 dimer interface [polypeptide binding]; other site 498214008512 putative CheW interface [polypeptide binding]; other site 498214008513 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 498214008514 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 498214008515 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 498214008516 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 498214008517 Spore germination protein; Region: Spore_permease; pfam03845 498214008518 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 498214008519 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 498214008520 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 498214008521 predicted active site [active] 498214008522 catalytic triad [active] 498214008523 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 498214008524 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 498214008525 active site 498214008526 multimer interface [polypeptide binding]; other site 498214008527 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 498214008528 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 498214008529 NodB motif; other site 498214008530 active site 498214008531 catalytic site [active] 498214008532 Zn binding site [ion binding]; other site 498214008533 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 498214008534 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 498214008535 ATP binding site [chemical binding]; other site 498214008536 Mg++ binding site [ion binding]; other site 498214008537 motif III; other site 498214008538 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498214008539 nucleotide binding region [chemical binding]; other site 498214008540 ATP-binding site [chemical binding]; other site 498214008541 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 498214008542 RNA binding site [nucleotide binding]; other site 498214008543 Probable zinc-binding domain; Region: zf-trcl; pfam13451 498214008544 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214008545 dimer interface [polypeptide binding]; other site 498214008546 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 498214008547 putative CheW interface [polypeptide binding]; other site 498214008548 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 498214008549 Ligand Binding Site [chemical binding]; other site 498214008550 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 498214008551 4Fe-4S binding domain; Region: Fer4_5; pfam12801 498214008552 glutaminase; Provisional; Region: PRK00971 498214008553 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 498214008554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 498214008555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 498214008556 Cache domain; Region: Cache_1; pfam02743 498214008557 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214008558 dimerization interface [polypeptide binding]; other site 498214008559 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498214008560 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214008561 dimer interface [polypeptide binding]; other site 498214008562 putative CheW interface [polypeptide binding]; other site 498214008563 TraX protein; Region: TraX; cl05434 498214008564 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 498214008565 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 498214008566 dimer interface [polypeptide binding]; other site 498214008567 putative radical transfer pathway; other site 498214008568 diiron center [ion binding]; other site 498214008569 tyrosyl radical; other site 498214008570 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088 498214008571 ATP cone domain; Region: ATP-cone; pfam03477 498214008572 Class I ribonucleotide reductase; Region: RNR_I; cd01679 498214008573 active site 498214008574 dimer interface [polypeptide binding]; other site 498214008575 catalytic residues [active] 498214008576 effector binding site; other site 498214008577 R2 peptide binding site; other site 498214008578 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 498214008579 Putative amidase domain; Region: Amidase_6; pfam12671 498214008580 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 498214008581 DNA polymerase IV; Provisional; Region: PRK14133 498214008582 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 498214008583 active site 498214008584 DNA binding site [nucleotide binding] 498214008585 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 498214008586 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 498214008587 homodimer interface [polypeptide binding]; other site 498214008588 active site 498214008589 FMN binding site [chemical binding]; other site 498214008590 substrate binding site [chemical binding]; other site 498214008591 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 498214008592 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 498214008593 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 498214008594 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498214008595 active site 498214008596 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 498214008597 Uncharacterized conserved protein [Function unknown]; Region: COG1434 498214008598 putative active site [active] 498214008599 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 498214008600 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 498214008601 putative DNA binding site [nucleotide binding]; other site 498214008602 putative Zn2+ binding site [ion binding]; other site 498214008603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214008604 Walker A/P-loop; other site 498214008605 ATP binding site [chemical binding]; other site 498214008606 Q-loop/lid; other site 498214008607 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 498214008608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214008609 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 498214008610 Walker A/P-loop; other site 498214008611 ATP binding site [chemical binding]; other site 498214008612 Q-loop/lid; other site 498214008613 ABC transporter signature motif; other site 498214008614 Walker B; other site 498214008615 D-loop; other site 498214008616 H-loop/switch region; other site 498214008617 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 498214008618 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 498214008619 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 498214008620 Carbohydrate binding domain; Region: CBM_25; smart01066 498214008621 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 498214008622 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 498214008623 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214008624 dimerization interface [polypeptide binding]; other site 498214008625 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214008626 dimer interface [polypeptide binding]; other site 498214008627 putative CheW interface [polypeptide binding]; other site 498214008628 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 498214008629 nudix motif; other site 498214008630 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 498214008631 Glyco_18 domain; Region: Glyco_18; smart00636 498214008632 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 498214008633 active site 498214008634 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 498214008635 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 498214008636 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 498214008637 active site 498214008638 trimer interface [polypeptide binding]; other site 498214008639 allosteric site; other site 498214008640 active site lid [active] 498214008641 hexamer (dimer of trimers) interface [polypeptide binding]; other site 498214008642 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 498214008643 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 498214008644 active site 498214008645 dimer interface [polypeptide binding]; other site 498214008646 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 498214008647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214008648 DNA-binding site [nucleotide binding]; DNA binding site 498214008649 UTRA domain; Region: UTRA; pfam07702 498214008650 CAT RNA binding domain; Region: CAT_RBD; smart01061 498214008651 transcriptional antiterminator BglG; Provisional; Region: PRK09772 498214008652 PRD domain; Region: PRD; pfam00874 498214008653 PRD domain; Region: PRD; pfam00874 498214008654 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 498214008655 HPr interaction site; other site 498214008656 glycerol kinase (GK) interaction site [polypeptide binding]; other site 498214008657 active site 498214008658 phosphorylation site [posttranslational modification] 498214008659 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 498214008660 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 498214008661 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 498214008662 active site turn [active] 498214008663 phosphorylation site [posttranslational modification] 498214008664 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 498214008665 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 498214008666 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 498214008667 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 498214008668 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 498214008669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214008670 Walker A/P-loop; other site 498214008671 ATP binding site [chemical binding]; other site 498214008672 Q-loop/lid; other site 498214008673 ABC transporter signature motif; other site 498214008674 Walker B; other site 498214008675 D-loop; other site 498214008676 H-loop/switch region; other site 498214008677 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 498214008678 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 498214008679 metal binding site 2 [ion binding]; metal-binding site 498214008680 putative DNA binding helix; other site 498214008681 metal binding site 1 [ion binding]; metal-binding site 498214008682 dimer interface [polypeptide binding]; other site 498214008683 structural Zn2+ binding site [ion binding]; other site 498214008684 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 498214008685 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 498214008686 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 498214008687 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498214008688 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 498214008689 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 498214008690 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 498214008691 FAD binding site [chemical binding]; other site 498214008692 homotetramer interface [polypeptide binding]; other site 498214008693 substrate binding pocket [chemical binding]; other site 498214008694 catalytic base [active] 498214008695 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 498214008696 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 498214008697 Rubredoxin; Region: Rubredoxin; pfam00301 498214008698 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 498214008699 iron binding site [ion binding]; other site 498214008700 HTH-like domain; Region: HTH_21; pfam13276 498214008701 Integrase core domain; Region: rve; pfam00665 498214008702 Integrase core domain; Region: rve_2; pfam13333 498214008703 Homeodomain-like domain; Region: HTH_23; cl17451 498214008704 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 498214008705 Transposase; Region: HTH_Tnp_1; cl17663 498214008706 Helix-turn-helix domain; Region: HTH_28; pfam13518 498214008707 Winged helix-turn helix; Region: HTH_29; pfam13551 498214008708 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 498214008709 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 498214008710 active site 498214008711 phosphorylation site [posttranslational modification] 498214008712 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 498214008713 Coenzyme A transferase; Region: CoA_trans; cl17247 498214008714 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 498214008715 Ligand binding site; other site 498214008716 metal-binding site 498214008717 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 498214008718 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 498214008719 catalytic loop [active] 498214008720 iron binding site [ion binding]; other site 498214008721 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 498214008722 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 498214008723 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 498214008724 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 498214008725 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 498214008726 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 498214008727 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 498214008728 active site turn [active] 498214008729 phosphorylation site [posttranslational modification] 498214008730 CAT RNA binding domain; Region: CAT_RBD; cl03904 498214008731 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 498214008732 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 498214008733 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 498214008734 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498214008735 motif II; other site 498214008736 TfoX C-terminal domain; Region: TfoX_C; pfam04994 498214008737 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 498214008738 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 498214008739 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 498214008740 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214008741 FeS/SAM binding site; other site 498214008742 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 498214008743 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498214008744 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498214008745 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 498214008746 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 498214008747 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 498214008748 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 498214008749 heme binding pocket [chemical binding]; other site 498214008750 TRAM domain; Region: TRAM; cl01282 498214008751 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 498214008752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214008753 S-adenosylmethionine binding site [chemical binding]; other site 498214008754 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 498214008755 Sulfatase; Region: Sulfatase; pfam00884 498214008756 hypothetical protein; Provisional; Region: PRK10621 498214008757 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 498214008758 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 498214008759 homopentamer interface [polypeptide binding]; other site 498214008760 active site 498214008761 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 498214008762 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 498214008763 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 498214008764 dimerization interface [polypeptide binding]; other site 498214008765 active site 498214008766 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 498214008767 Lumazine binding domain; Region: Lum_binding; pfam00677 498214008768 Lumazine binding domain; Region: Lum_binding; pfam00677 498214008769 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 498214008770 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 498214008771 catalytic motif [active] 498214008772 Zn binding site [ion binding]; other site 498214008773 RibD C-terminal domain; Region: RibD_C; cl17279 498214008774 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 498214008775 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 498214008776 metal binding site [ion binding]; metal-binding site 498214008777 dimer interface [polypeptide binding]; other site 498214008778 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498214008779 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 498214008780 magnesium-transporting ATPase; Provisional; Region: PRK15122 498214008781 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 498214008782 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 498214008783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498214008784 motif II; other site 498214008785 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 498214008786 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 498214008787 active site 498214008788 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 498214008789 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 498214008790 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 498214008791 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 498214008792 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 498214008793 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 498214008794 purine monophosphate binding site [chemical binding]; other site 498214008795 dimer interface [polypeptide binding]; other site 498214008796 putative catalytic residues [active] 498214008797 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 498214008798 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 498214008799 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 498214008800 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 498214008801 active site 498214008802 substrate binding site [chemical binding]; other site 498214008803 cosubstrate binding site; other site 498214008804 catalytic site [active] 498214008805 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 498214008806 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 498214008807 dimerization interface [polypeptide binding]; other site 498214008808 putative ATP binding site [chemical binding]; other site 498214008809 amidophosphoribosyltransferase; Provisional; Region: PRK05793 498214008810 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 498214008811 active site 498214008812 tetramer interface [polypeptide binding]; other site 498214008813 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498214008814 active site 498214008815 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 498214008816 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 498214008817 ATP binding site [chemical binding]; other site 498214008818 active site 498214008819 substrate binding site [chemical binding]; other site 498214008820 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 498214008821 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 498214008822 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 498214008823 catalytic loop [active] 498214008824 iron binding site [ion binding]; other site 498214008825 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 498214008826 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 498214008827 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 498214008828 peptidase; Reviewed; Region: PRK13004 498214008829 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 498214008830 putative metal binding site [ion binding]; other site 498214008831 putative dimer interface [polypeptide binding]; other site 498214008832 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 498214008833 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 498214008834 active site 498214008835 putative substrate binding pocket [chemical binding]; other site 498214008836 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 498214008837 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 498214008838 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 498214008839 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 498214008840 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 498214008841 phenylhydantoinase; Validated; Region: PRK08323 498214008842 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 498214008843 tetramer interface [polypeptide binding]; other site 498214008844 active site 498214008845 xanthine permease; Region: pbuX; TIGR03173 498214008846 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 498214008847 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 498214008848 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498214008849 catalytic residue [active] 498214008850 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 498214008851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214008852 Walker A motif; other site 498214008853 ATP binding site [chemical binding]; other site 498214008854 Walker B motif; other site 498214008855 arginine finger; other site 498214008856 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 498214008857 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 498214008858 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 498214008859 Ligand binding site; other site 498214008860 metal-binding site 498214008861 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 498214008862 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 498214008863 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 498214008864 XdhC Rossmann domain; Region: XdhC_C; pfam13478 498214008865 NTPase; Region: NTPase_1; pfam03266 498214008866 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 498214008867 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 498214008868 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 498214008869 ABC-ATPase subunit interface; other site 498214008870 dimer interface [polypeptide binding]; other site 498214008871 putative PBP binding regions; other site 498214008872 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 498214008873 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 498214008874 Walker A/P-loop; other site 498214008875 ATP binding site [chemical binding]; other site 498214008876 Q-loop/lid; other site 498214008877 ABC transporter signature motif; other site 498214008878 Walker B; other site 498214008879 D-loop; other site 498214008880 H-loop/switch region; other site 498214008881 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 498214008882 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 498214008883 intersubunit interface [polypeptide binding]; other site 498214008884 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 498214008885 active site 498214008886 catalytic triad [active] 498214008887 oxyanion hole [active] 498214008888 Uncharacterized conserved protein [Function unknown]; Region: COG1434 498214008889 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 498214008890 putative active site [active] 498214008891 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 498214008892 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 498214008893 amino acid carrier protein; Region: agcS; TIGR00835 498214008894 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 498214008895 Part of AAA domain; Region: AAA_19; pfam13245 498214008896 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 498214008897 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 498214008898 Ligand Binding Site [chemical binding]; other site 498214008899 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 498214008900 putative metal binding site [ion binding]; other site 498214008901 putative dimer interface [polypeptide binding]; other site 498214008902 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 498214008903 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 498214008904 Domain of unknown function DUF21; Region: DUF21; pfam01595 498214008905 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 498214008906 Transporter associated domain; Region: CorC_HlyC; pfam03471 498214008907 Domain of unknown function DUF77; Region: DUF77; pfam01910 498214008908 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 498214008909 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 498214008910 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 498214008911 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 498214008912 active site 498214008913 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498214008914 active site 498214008915 Protein of unknown function (DUF503); Region: DUF503; pfam04456 498214008916 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 498214008917 Ferredoxin [Energy production and conversion]; Region: COG1146 498214008918 4Fe-4S binding domain; Region: Fer4_6; pfam12837 498214008919 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 498214008920 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 498214008921 ligand binding site [chemical binding]; other site 498214008922 flexible hinge region; other site 498214008923 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 498214008924 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 498214008925 Predicted membrane protein [Function unknown]; Region: COG1511 498214008926 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 498214008927 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 498214008928 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 498214008929 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 498214008930 active site 498214008931 catalytic site [active] 498214008932 metal binding site [ion binding]; metal-binding site 498214008933 dimer interface [polypeptide binding]; other site 498214008934 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 498214008935 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498214008936 catalytic residue [active] 498214008937 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 498214008938 Domain of unknown function DUF21; Region: DUF21; pfam01595 498214008939 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 498214008940 Transporter associated domain; Region: CorC_HlyC; pfam03471 498214008941 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 498214008942 Putative zinc ribbon domain; Region: DUF164; pfam02591 498214008943 Uncharacterized conserved protein [Function unknown]; Region: COG0327 498214008944 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 498214008945 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 498214008946 Family of unknown function (DUF633); Region: DUF633; pfam04816 498214008947 Protein of unknown function (DUF2679); Region: DUF2679; pfam10882 498214008948 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 498214008949 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 498214008950 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 498214008951 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498214008952 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 498214008953 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498214008954 DNA binding residues [nucleotide binding] 498214008955 DNA primase, catalytic core; Region: dnaG; TIGR01391 498214008956 CHC2 zinc finger; Region: zf-CHC2; pfam01807 498214008957 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 498214008958 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 498214008959 active site 498214008960 metal binding site [ion binding]; metal-binding site 498214008961 interdomain interaction site; other site 498214008962 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 498214008963 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 498214008964 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214008965 Zn2+ binding site [ion binding]; other site 498214008966 Mg2+ binding site [ion binding]; other site 498214008967 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 498214008968 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 498214008969 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 498214008970 pyruvate phosphate dikinase; Provisional; Region: PRK09279 498214008971 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 498214008972 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 498214008973 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 498214008974 HTH domain; Region: HTH_11; pfam08279 498214008975 FOG: CBS domain [General function prediction only]; Region: COG0517 498214008976 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 498214008977 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 498214008978 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 498214008979 GTPase Era; Reviewed; Region: era; PRK00089 498214008980 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 498214008981 G1 box; other site 498214008982 GTP/Mg2+ binding site [chemical binding]; other site 498214008983 Switch I region; other site 498214008984 G2 box; other site 498214008985 Switch II region; other site 498214008986 G3 box; other site 498214008987 G4 box; other site 498214008988 G5 box; other site 498214008989 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 498214008990 active site 498214008991 catalytic motif [active] 498214008992 Zn binding site [ion binding]; other site 498214008993 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 498214008994 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 498214008995 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 498214008996 active site 498214008997 metal-binding heat shock protein; Provisional; Region: PRK00016 498214008998 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 498214008999 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 498214009000 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214009001 Zn2+ binding site [ion binding]; other site 498214009002 Mg2+ binding site [ion binding]; other site 498214009003 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 498214009004 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 498214009005 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 498214009006 Yqey-like protein; Region: YqeY; pfam09424 498214009007 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 498214009008 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 498214009009 nucleotide binding site/active site [active] 498214009010 HIT family signature motif; other site 498214009011 catalytic residue [active] 498214009012 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 498214009013 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 498214009014 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214009015 FeS/SAM binding site; other site 498214009016 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 498214009017 RNA methyltransferase, RsmE family; Region: TIGR00046 498214009018 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 498214009019 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 498214009020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214009021 S-adenosylmethionine binding site [chemical binding]; other site 498214009022 chaperone protein DnaJ; Provisional; Region: PRK14297 498214009023 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 498214009024 HSP70 interaction site [polypeptide binding]; other site 498214009025 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 498214009026 substrate binding site [polypeptide binding]; other site 498214009027 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 498214009028 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 498214009029 dimer interface [polypeptide binding]; other site 498214009030 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 498214009031 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 498214009032 nucleotide binding site [chemical binding]; other site 498214009033 NEF interaction site [polypeptide binding]; other site 498214009034 SBD interface [polypeptide binding]; other site 498214009035 GrpE; Region: GrpE; pfam01025 498214009036 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 498214009037 dimer interface [polypeptide binding]; other site 498214009038 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 498214009039 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 498214009040 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 498214009041 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 498214009042 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214009043 FeS/SAM binding site; other site 498214009044 HemN C-terminal domain; Region: HemN_C; pfam06969 498214009045 GTP-binding protein LepA; Provisional; Region: PRK05433 498214009046 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 498214009047 G1 box; other site 498214009048 putative GEF interaction site [polypeptide binding]; other site 498214009049 GTP/Mg2+ binding site [chemical binding]; other site 498214009050 Switch I region; other site 498214009051 G2 box; other site 498214009052 G3 box; other site 498214009053 Switch II region; other site 498214009054 G4 box; other site 498214009055 G5 box; other site 498214009056 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 498214009057 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 498214009058 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 498214009059 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 498214009060 stage II sporulation protein P; Region: spore_II_P; TIGR02867 498214009061 germination protease; Provisional; Region: PRK12362 498214009062 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 498214009063 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 498214009064 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 498214009065 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 498214009066 Competence protein; Region: Competence; pfam03772 498214009067 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 498214009068 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 498214009069 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 498214009070 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 498214009071 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 498214009072 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 498214009073 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 498214009074 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 498214009075 G1 box; other site 498214009076 putative GEF interaction site [polypeptide binding]; other site 498214009077 GTP/Mg2+ binding site [chemical binding]; other site 498214009078 Switch I region; other site 498214009079 G2 box; other site 498214009080 G3 box; other site 498214009081 Switch II region; other site 498214009082 G4 box; other site 498214009083 G5 box; other site 498214009084 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 498214009085 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 498214009086 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 498214009087 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 498214009088 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 498214009089 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 498214009090 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 498214009091 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498214009092 catalytic residue [active] 498214009093 selenophosphate synthetase; Provisional; Region: PRK00943 498214009094 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 498214009095 dimerization interface [polypeptide binding]; other site 498214009096 putative ATP binding site [chemical binding]; other site 498214009097 SLBB domain; Region: SLBB; pfam10531 498214009098 Helix-hairpin-helix motif; Region: HHH; pfam00633 498214009099 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 498214009100 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 498214009101 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 498214009102 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 498214009103 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 498214009104 RNA binding surface [nucleotide binding]; other site 498214009105 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 498214009106 active site 498214009107 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 498214009108 homotrimer interaction site [polypeptide binding]; other site 498214009109 putative active site [active] 498214009110 Transcriptional regulator [Transcription]; Region: LytR; COG1316 498214009111 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 498214009112 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214009113 Zn2+ binding site [ion binding]; other site 498214009114 Mg2+ binding site [ion binding]; other site 498214009115 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 498214009116 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 498214009117 active site 498214009118 (T/H)XGH motif; other site 498214009119 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 498214009120 GTPase CgtA; Reviewed; Region: obgE; PRK12297 498214009121 GTP1/OBG; Region: GTP1_OBG; pfam01018 498214009122 Obg GTPase; Region: Obg; cd01898 498214009123 G1 box; other site 498214009124 GTP/Mg2+ binding site [chemical binding]; other site 498214009125 Switch I region; other site 498214009126 G2 box; other site 498214009127 G3 box; other site 498214009128 Switch II region; other site 498214009129 G4 box; other site 498214009130 G5 box; other site 498214009131 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 498214009132 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 498214009133 hypothetical protein; Provisional; Region: PRK14553 498214009134 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 498214009135 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 498214009136 homodimer interface [polypeptide binding]; other site 498214009137 oligonucleotide binding site [chemical binding]; other site 498214009138 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 498214009139 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 498214009140 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 498214009141 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 498214009142 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214009143 FeS/SAM binding site; other site 498214009144 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 498214009145 Peptidase family M50; Region: Peptidase_M50; pfam02163 498214009146 active site 498214009147 putative substrate binding region [chemical binding]; other site 498214009148 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 498214009149 Peptidase family M23; Region: Peptidase_M23; pfam01551 498214009150 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 498214009151 cell division topological specificity factor MinE; Provisional; Region: PRK13987 498214009152 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 498214009153 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 498214009154 Switch I; other site 498214009155 Switch II; other site 498214009156 septum formation inhibitor; Reviewed; Region: minC; PRK00513 498214009157 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 498214009158 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 498214009159 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 498214009160 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 498214009161 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 498214009162 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 498214009163 rod shape-determining protein MreC; Provisional; Region: PRK13922 498214009164 rod shape-determining protein MreC; Region: MreC; pfam04085 498214009165 rod shape-determining protein MreB; Provisional; Region: PRK13927 498214009166 MreB and similar proteins; Region: MreB_like; cd10225 498214009167 nucleotide binding site [chemical binding]; other site 498214009168 Mg binding site [ion binding]; other site 498214009169 putative protofilament interaction site [polypeptide binding]; other site 498214009170 RodZ interaction site [polypeptide binding]; other site 498214009171 hypothetical protein; Reviewed; Region: PRK00024 498214009172 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 498214009173 helix-hairpin-helix signature motif; other site 498214009174 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 498214009175 MPN+ (JAMM) motif; other site 498214009176 Zinc-binding site [ion binding]; other site 498214009177 Maf-like protein; Reviewed; Region: PRK00078 498214009178 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 498214009179 active site 498214009180 dimer interface [polypeptide binding]; other site 498214009181 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 498214009182 Sporulation related domain; Region: SPOR; cl10051 498214009183 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 498214009184 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 498214009185 hypothetical protein; Provisional; Region: PRK04435 498214009186 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 498214009187 DNA-binding interface [nucleotide binding]; DNA binding site 498214009188 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 498214009189 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 498214009190 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 498214009191 N-acetyl-D-glucosamine binding site [chemical binding]; other site 498214009192 catalytic residue [active] 498214009193 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 498214009194 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 498214009195 CoA-binding site [chemical binding]; other site 498214009196 ATP-binding [chemical binding]; other site 498214009197 DNA polymerase I; Provisional; Region: PRK05755 498214009198 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 498214009199 active site 498214009200 metal binding site 1 [ion binding]; metal-binding site 498214009201 putative 5' ssDNA interaction site; other site 498214009202 metal binding site 3; metal-binding site 498214009203 metal binding site 2 [ion binding]; metal-binding site 498214009204 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 498214009205 putative DNA binding site [nucleotide binding]; other site 498214009206 putative metal binding site [ion binding]; other site 498214009207 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 498214009208 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 498214009209 active site 498214009210 DNA binding site [nucleotide binding] 498214009211 catalytic site [active] 498214009212 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 498214009213 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 498214009214 Tetramer interface [polypeptide binding]; other site 498214009215 active site 498214009216 FMN-binding site [chemical binding]; other site 498214009217 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 498214009218 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 498214009219 active site 498214009220 metal binding site [ion binding]; metal-binding site 498214009221 Bacterial SH3 domain; Region: SH3_3; pfam08239 498214009222 Haemolysin XhlA; Region: XhlA; pfam10779 498214009223 SPRY domain; Region: SPRY; cl02614 498214009224 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 498214009225 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 498214009226 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_2; pfam07727 498214009227 SPRY domain; Region: SPRY; cd11709 498214009228 Caspase domain; Region: Peptidase_C14; pfam00656 498214009229 DivIVA protein; Region: DivIVA; pfam05103 498214009230 Bacterial Ig-like domain; Region: Big_5; pfam13205 498214009231 hypothetical protein; Validated; Region: PRK08116 498214009232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214009233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 498214009234 Walker A motif; other site 498214009235 ATP binding site [chemical binding]; other site 498214009236 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 498214009237 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 498214009238 non-specific DNA binding site [nucleotide binding]; other site 498214009239 salt bridge; other site 498214009240 sequence-specific DNA binding site [nucleotide binding]; other site 498214009241 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214009242 non-specific DNA binding site [nucleotide binding]; other site 498214009243 salt bridge; other site 498214009244 sequence-specific DNA binding site [nucleotide binding]; other site 498214009245 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 498214009246 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214009247 non-specific DNA binding site [nucleotide binding]; other site 498214009248 salt bridge; other site 498214009249 sequence-specific DNA binding site [nucleotide binding]; other site 498214009250 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 498214009251 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 498214009252 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 498214009253 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 498214009254 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 498214009255 dimer interface [polypeptide binding]; other site 498214009256 anticodon binding site; other site 498214009257 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 498214009258 homodimer interface [polypeptide binding]; other site 498214009259 motif 1; other site 498214009260 active site 498214009261 motif 2; other site 498214009262 GAD domain; Region: GAD; pfam02938 498214009263 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 498214009264 motif 3; other site 498214009265 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 498214009266 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 498214009267 dimer interface [polypeptide binding]; other site 498214009268 motif 1; other site 498214009269 active site 498214009270 motif 2; other site 498214009271 motif 3; other site 498214009272 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 498214009273 anticodon binding site; other site 498214009274 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 498214009275 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214009276 FeS/SAM binding site; other site 498214009277 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 498214009278 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 498214009279 putative active site [active] 498214009280 dimerization interface [polypeptide binding]; other site 498214009281 putative tRNAtyr binding site [nucleotide binding]; other site 498214009282 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 498214009283 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214009284 Zn2+ binding site [ion binding]; other site 498214009285 Mg2+ binding site [ion binding]; other site 498214009286 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 498214009287 synthetase active site [active] 498214009288 NTP binding site [chemical binding]; other site 498214009289 metal binding site [ion binding]; metal-binding site 498214009290 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 498214009291 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 498214009292 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498214009293 active site 498214009294 DHH family; Region: DHH; pfam01368 498214009295 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 498214009296 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 498214009297 Protein export membrane protein; Region: SecD_SecF; pfam02355 498214009298 protein-export membrane protein SecD; Region: secD; TIGR01129 498214009299 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 498214009300 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 498214009301 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214009302 FeS/SAM binding site; other site 498214009303 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 498214009304 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 498214009305 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 498214009306 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 498214009307 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 498214009308 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 498214009309 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 498214009310 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 498214009311 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 498214009312 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 498214009313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214009314 Walker A motif; other site 498214009315 ATP binding site [chemical binding]; other site 498214009316 Walker B motif; other site 498214009317 arginine finger; other site 498214009318 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 498214009319 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 498214009320 RuvA N terminal domain; Region: RuvA_N; pfam01330 498214009321 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 498214009322 hypothetical protein; Validated; Region: PRK00110 498214009323 Uncharacterized conserved protein [Function unknown]; Region: COG1739 498214009324 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 498214009325 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 498214009326 HEAT-like repeat; Region: HEAT_EZ; pfam13513 498214009327 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 498214009328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 498214009329 DNA-binding site [nucleotide binding]; DNA binding site 498214009330 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498214009331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214009332 homodimer interface [polypeptide binding]; other site 498214009333 catalytic residue [active] 498214009334 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 498214009335 active site 498214009336 NTP binding site [chemical binding]; other site 498214009337 metal binding triad [ion binding]; metal-binding site 498214009338 antibiotic binding site [chemical binding]; other site 498214009339 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 498214009340 Rubredoxin; Region: Rubredoxin; pfam00301 498214009341 iron binding site [ion binding]; other site 498214009342 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 498214009343 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 498214009344 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 498214009345 HflX GTPase family; Region: HflX; cd01878 498214009346 G1 box; other site 498214009347 GTP/Mg2+ binding site [chemical binding]; other site 498214009348 Switch I region; other site 498214009349 G2 box; other site 498214009350 G3 box; other site 498214009351 Switch II region; other site 498214009352 G4 box; other site 498214009353 G5 box; other site 498214009354 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498214009355 active site 498214009356 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 498214009357 Transglycosylase; Region: Transgly; pfam00912 498214009358 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 498214009359 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 498214009360 SpoVA protein; Region: SpoVA; cl04298 498214009361 stage V sporulation protein AD; Validated; Region: PRK08304 498214009362 stage V sporulation protein AD; Provisional; Region: PRK12404 498214009363 SpoVA protein; Region: SpoVA; cl04298 498214009364 sporulation sigma factor SigF; Validated; Region: PRK05572 498214009365 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498214009366 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 498214009367 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 498214009368 DNA binding residues [nucleotide binding] 498214009369 anti-sigma F factor; Provisional; Region: PRK03660 498214009370 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 498214009371 ATP binding site [chemical binding]; other site 498214009372 Mg2+ binding site [ion binding]; other site 498214009373 G-X-G motif; other site 498214009374 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 498214009375 anti sigma factor interaction site; other site 498214009376 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 498214009377 regulatory phosphorylation site [posttranslational modification]; other site 498214009378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 498214009379 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 498214009380 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 498214009381 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 498214009382 NodB motif; other site 498214009383 active site 498214009384 catalytic site [active] 498214009385 Cd binding site [ion binding]; other site 498214009386 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 498214009387 Bacterial sugar transferase; Region: Bac_transf; pfam02397 498214009388 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 498214009389 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 498214009390 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 498214009391 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 498214009392 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 498214009393 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 498214009394 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 498214009395 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 498214009396 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 498214009397 O-Antigen ligase; Region: Wzy_C; pfam04932 498214009398 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 498214009399 putative glycosyl transferase; Provisional; Region: PRK10307 498214009400 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 498214009401 active site 498214009402 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 498214009403 homodimer interface [polypeptide binding]; other site 498214009404 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 498214009405 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 498214009406 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 498214009407 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 498214009408 Leucine rich repeat; Region: LRR_8; pfam13855 498214009409 Leucine-rich repeats; other site 498214009410 Substrate binding site [chemical binding]; other site 498214009411 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498214009412 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498214009413 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498214009414 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 498214009415 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 498214009416 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 498214009417 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 498214009418 putative trimer interface [polypeptide binding]; other site 498214009419 putative CoA binding site [chemical binding]; other site 498214009420 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 498214009421 putative trimer interface [polypeptide binding]; other site 498214009422 putative active site [active] 498214009423 putative substrate binding site [chemical binding]; other site 498214009424 putative CoA binding site [chemical binding]; other site 498214009425 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 498214009426 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 498214009427 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 498214009428 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 498214009429 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 498214009430 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 498214009431 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 498214009432 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 498214009433 NAD(P) binding site [chemical binding]; other site 498214009434 homodimer interface [polypeptide binding]; other site 498214009435 substrate binding site [chemical binding]; other site 498214009436 active site 498214009437 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 498214009438 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 498214009439 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 498214009440 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 498214009441 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 498214009442 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 498214009443 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 498214009444 active site 498214009445 metal binding site [ion binding]; metal-binding site 498214009446 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 498214009447 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 498214009448 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 498214009449 active site 498214009450 metal binding site [ion binding]; metal-binding site 498214009451 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 498214009452 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 498214009453 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 498214009454 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 498214009455 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 498214009456 active site 498214009457 tetramer interface; other site 498214009458 Tetratricopeptide repeat; Region: TPR_12; pfam13424 498214009459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 498214009460 binding surface 498214009461 TPR motif; other site 498214009462 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 498214009463 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 498214009464 active site 498214009465 substrate binding site [chemical binding]; other site 498214009466 metal binding site [ion binding]; metal-binding site 498214009467 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 498214009468 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 498214009469 5S rRNA interface [nucleotide binding]; other site 498214009470 CTC domain interface [polypeptide binding]; other site 498214009471 L16 interface [polypeptide binding]; other site 498214009472 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 498214009473 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 498214009474 homodimer interface [polypeptide binding]; other site 498214009475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214009476 catalytic residue [active] 498214009477 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 498214009478 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 498214009479 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 498214009480 active site 498214009481 substrate binding site [chemical binding]; other site 498214009482 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 498214009483 FMN binding site [chemical binding]; other site 498214009484 putative catalytic residues [active] 498214009485 Uncharacterized conserved protein [Function unknown]; Region: COG1683 498214009486 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 498214009487 MutS domain III; Region: MutS_III; pfam05192 498214009488 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 498214009489 Walker A/P-loop; other site 498214009490 ATP binding site [chemical binding]; other site 498214009491 Q-loop/lid; other site 498214009492 ABC transporter signature motif; other site 498214009493 Walker B; other site 498214009494 D-loop; other site 498214009495 H-loop/switch region; other site 498214009496 Smr domain; Region: Smr; pfam01713 498214009497 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 498214009498 Peptidase family U32; Region: Peptidase_U32; pfam01136 498214009499 Collagenase; Region: DUF3656; pfam12392 498214009500 Peptidase family U32; Region: Peptidase_U32; cl03113 498214009501 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 498214009502 Cell division protein ZapA; Region: ZapA; pfam05164 498214009503 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 498214009504 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 498214009505 putative tRNA-binding site [nucleotide binding]; other site 498214009506 B3/4 domain; Region: B3_4; pfam03483 498214009507 tRNA synthetase B5 domain; Region: B5; smart00874 498214009508 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 498214009509 dimer interface [polypeptide binding]; other site 498214009510 motif 1; other site 498214009511 motif 3; other site 498214009512 motif 2; other site 498214009513 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 498214009514 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 498214009515 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 498214009516 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 498214009517 dimer interface [polypeptide binding]; other site 498214009518 motif 1; other site 498214009519 active site 498214009520 motif 2; other site 498214009521 motif 3; other site 498214009522 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 498214009523 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 498214009524 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 498214009525 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 498214009526 TrkA-N domain; Region: TrkA_N; pfam02254 498214009527 TrkA-C domain; Region: TrkA_C; pfam02080 498214009528 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 498214009529 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 498214009530 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 498214009531 23S rRNA binding site [nucleotide binding]; other site 498214009532 L21 binding site [polypeptide binding]; other site 498214009533 L13 binding site [polypeptide binding]; other site 498214009534 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 498214009535 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 498214009536 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 498214009537 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 498214009538 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 498214009539 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 498214009540 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 498214009541 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 498214009542 active site 498214009543 dimer interface [polypeptide binding]; other site 498214009544 motif 1; other site 498214009545 motif 2; other site 498214009546 motif 3; other site 498214009547 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 498214009548 anticodon binding site; other site 498214009549 YtxC-like family; Region: YtxC; pfam08812 498214009550 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 498214009551 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 498214009552 Walker A/P-loop; other site 498214009553 ATP binding site [chemical binding]; other site 498214009554 Q-loop/lid; other site 498214009555 ABC transporter signature motif; other site 498214009556 Walker B; other site 498214009557 D-loop; other site 498214009558 H-loop/switch region; other site 498214009559 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 498214009560 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 498214009561 dimerization interface [polypeptide binding]; other site 498214009562 domain crossover interface; other site 498214009563 redox-dependent activation switch; other site 498214009564 Methyltransferase domain; Region: Methyltransf_23; pfam13489 498214009565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214009566 S-adenosylmethionine binding site [chemical binding]; other site 498214009567 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 498214009568 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 498214009569 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 498214009570 Walker A/P-loop; other site 498214009571 ATP binding site [chemical binding]; other site 498214009572 Q-loop/lid; other site 498214009573 ABC transporter signature motif; other site 498214009574 Walker B; other site 498214009575 D-loop; other site 498214009576 H-loop/switch region; other site 498214009577 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 498214009578 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 498214009579 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 498214009580 Walker A/P-loop; other site 498214009581 ATP binding site [chemical binding]; other site 498214009582 Q-loop/lid; other site 498214009583 ABC transporter signature motif; other site 498214009584 Walker B; other site 498214009585 D-loop; other site 498214009586 H-loop/switch region; other site 498214009587 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 498214009588 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 498214009589 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 498214009590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214009591 putative PBP binding loops; other site 498214009592 dimer interface [polypeptide binding]; other site 498214009593 ABC-ATPase subunit interface; other site 498214009594 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 498214009595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214009596 dimer interface [polypeptide binding]; other site 498214009597 conserved gate region; other site 498214009598 putative PBP binding loops; other site 498214009599 ABC-ATPase subunit interface; other site 498214009600 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 498214009601 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 498214009602 peptide binding site [polypeptide binding]; other site 498214009603 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 498214009604 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 498214009605 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 498214009606 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 498214009607 dimer interface [polypeptide binding]; other site 498214009608 active site 498214009609 catalytic residue [active] 498214009610 dihydrodipicolinate reductase; Provisional; Region: PRK00048 498214009611 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 498214009612 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 498214009613 aminotransferase A; Validated; Region: PRK07683 498214009614 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 498214009615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214009616 homodimer interface [polypeptide binding]; other site 498214009617 catalytic residue [active] 498214009618 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 498214009619 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 498214009620 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 498214009621 trimer interface [polypeptide binding]; other site 498214009622 active site 498214009623 substrate binding site [chemical binding]; other site 498214009624 CoA binding site [chemical binding]; other site 498214009625 single-stranded DNA-binding protein; Provisional; Region: PRK05813 498214009626 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 498214009627 dimer interface [polypeptide binding]; other site 498214009628 ssDNA binding site [nucleotide binding]; other site 498214009629 tetramer (dimer of dimers) interface [polypeptide binding]; other site 498214009630 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 498214009631 NodB motif; other site 498214009632 active site 498214009633 catalytic site [active] 498214009634 metal binding site [ion binding]; metal-binding site 498214009635 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 498214009636 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 498214009637 uncharacterized protein TIGR03905; Region: TIGR03905_4_Cys 498214009638 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 498214009639 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 498214009640 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 498214009641 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 498214009642 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 498214009643 active site 498214009644 HIGH motif; other site 498214009645 nucleotide binding site [chemical binding]; other site 498214009646 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 498214009647 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 498214009648 active site 498214009649 KMSKS motif; other site 498214009650 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 498214009651 tRNA binding surface [nucleotide binding]; other site 498214009652 anticodon binding site; other site 498214009653 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 498214009654 putative acetyltransferase YhhY; Provisional; Region: PRK10140 498214009655 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214009656 Coenzyme A binding pocket [chemical binding]; other site 498214009657 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 498214009658 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214009659 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498214009660 Walker A/P-loop; other site 498214009661 ATP binding site [chemical binding]; other site 498214009662 Q-loop/lid; other site 498214009663 ABC transporter signature motif; other site 498214009664 Walker B; other site 498214009665 D-loop; other site 498214009666 H-loop/switch region; other site 498214009667 FtsX-like permease family; Region: FtsX; pfam02687 498214009668 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 498214009669 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 498214009670 Walker A/P-loop; other site 498214009671 ATP binding site [chemical binding]; other site 498214009672 Q-loop/lid; other site 498214009673 ABC transporter signature motif; other site 498214009674 Walker B; other site 498214009675 D-loop; other site 498214009676 H-loop/switch region; other site 498214009677 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 498214009678 FtsX-like permease family; Region: FtsX; pfam02687 498214009679 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 498214009680 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 498214009681 FtsX-like permease family; Region: FtsX; pfam02687 498214009682 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 498214009683 NMT1-like family; Region: NMT1_2; pfam13379 498214009684 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 498214009685 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 498214009686 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 498214009687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 498214009688 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 498214009689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 498214009690 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 498214009691 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 498214009692 Walker A/P-loop; other site 498214009693 ATP binding site [chemical binding]; other site 498214009694 Q-loop/lid; other site 498214009695 ABC transporter signature motif; other site 498214009696 Walker B; other site 498214009697 D-loop; other site 498214009698 H-loop/switch region; other site 498214009699 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 498214009700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214009701 dimer interface [polypeptide binding]; other site 498214009702 conserved gate region; other site 498214009703 putative PBP binding loops; other site 498214009704 ABC-ATPase subunit interface; other site 498214009705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 498214009706 TPR repeat; Region: TPR_11; pfam13414 498214009707 binding surface 498214009708 TPR motif; other site 498214009709 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 498214009710 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 498214009711 recombination regulator RecX; Provisional; Region: recX; PRK14134 498214009712 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 498214009713 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 498214009714 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 498214009715 QueT transporter; Region: QueT; pfam06177 498214009716 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 498214009717 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 498214009718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 498214009719 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 498214009720 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 498214009721 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 498214009722 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 498214009723 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 498214009724 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 498214009725 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 498214009726 dimer interface [polypeptide binding]; other site 498214009727 active site 498214009728 glycine loop; other site 498214009729 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 498214009730 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 498214009731 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 498214009732 FeS/SAM binding site; other site 498214009733 sequence-specific DNA binding site [nucleotide binding]; other site 498214009734 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 498214009735 salt bridge; other site 498214009736 Cupin domain; Region: Cupin_2; pfam07883 498214009737 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 498214009738 Dimer interface [polypeptide binding]; other site 498214009739 BRCT sequence motif; other site 498214009740 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 498214009741 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 498214009742 metal ion-dependent adhesion site (MIDAS); other site 498214009743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214009744 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 498214009745 Walker A motif; other site 498214009746 ATP binding site [chemical binding]; other site 498214009747 Walker B motif; other site 498214009748 arginine finger; other site 498214009749 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528 498214009750 Uncharacterized conserved protein [Function unknown]; Region: COG1915 498214009751 Uncharacterized conserved protein [Function unknown]; Region: COG1915 498214009752 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 498214009753 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 498214009754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 498214009755 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 498214009756 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 498214009757 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 498214009758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214009759 Walker A motif; other site 498214009760 ATP binding site [chemical binding]; other site 498214009761 Walker B motif; other site 498214009762 arginine finger; other site 498214009763 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 498214009764 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 498214009765 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 498214009766 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 498214009767 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 498214009768 Ligand binding site [chemical binding]; other site 498214009769 Electron transfer flavoprotein domain; Region: ETF; pfam01012 498214009770 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 498214009771 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 498214009772 FAD binding site [chemical binding]; other site 498214009773 homotetramer interface [polypeptide binding]; other site 498214009774 substrate binding pocket [chemical binding]; other site 498214009775 catalytic base [active] 498214009776 putative acyltransferase; Provisional; Region: PRK05790 498214009777 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 498214009778 dimer interface [polypeptide binding]; other site 498214009779 active site 498214009780 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 498214009781 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 498214009782 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 498214009783 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 498214009784 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 498214009785 substrate binding site [chemical binding]; other site 498214009786 oxyanion hole (OAH) forming residues; other site 498214009787 trimer interface [polypeptide binding]; other site 498214009788 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 498214009789 GIY-YIG motif/motif A; other site 498214009790 active site 498214009791 catalytic site [active] 498214009792 putative DNA binding site [nucleotide binding]; other site 498214009793 metal binding site [ion binding]; metal-binding site 498214009794 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 498214009795 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214009796 Zn2+ binding site [ion binding]; other site 498214009797 Mg2+ binding site [ion binding]; other site 498214009798 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 498214009799 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 498214009800 homotetramer interface [polypeptide binding]; other site 498214009801 active site 498214009802 metal binding site [ion binding]; metal-binding site 498214009803 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 498214009804 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 498214009805 active site 498214009806 catalytic site [active] 498214009807 metal binding site [ion binding]; metal-binding site 498214009808 dimer interface [polypeptide binding]; other site 498214009809 Cache domain; Region: Cache_1; pfam02743 498214009810 HAMP domain; Region: HAMP; pfam00672 498214009811 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498214009812 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214009813 dimer interface [polypeptide binding]; other site 498214009814 putative CheW interface [polypeptide binding]; other site 498214009815 Rubredoxin [Energy production and conversion]; Region: COG1773 498214009816 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 498214009817 iron binding site [ion binding]; other site 498214009818 Rubrerythrin [Energy production and conversion]; Region: COG1592 498214009819 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 498214009820 diiron binding motif [ion binding]; other site 498214009821 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 498214009822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214009823 FeS/SAM binding site; other site 498214009824 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 498214009825 Pyruvate formate lyase 1; Region: PFL1; cd01678 498214009826 coenzyme A binding site [chemical binding]; other site 498214009827 active site 498214009828 catalytic residues [active] 498214009829 glycine loop; other site 498214009830 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 498214009831 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 498214009832 5S rRNA interface [nucleotide binding]; other site 498214009833 CTC domain interface [polypeptide binding]; other site 498214009834 L16 interface [polypeptide binding]; other site 498214009835 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 498214009836 metal binding site 2 [ion binding]; metal-binding site 498214009837 putative DNA binding helix; other site 498214009838 metal binding site 1 [ion binding]; metal-binding site 498214009839 dimer interface [polypeptide binding]; other site 498214009840 structural Zn2+ binding site [ion binding]; other site 498214009841 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 498214009842 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 498214009843 Predicted transcriptional regulator [Transcription]; Region: COG2378 498214009844 HTH domain; Region: HTH_11; pfam08279 498214009845 WYL domain; Region: WYL; pfam13280 498214009846 CAAX protease self-immunity; Region: Abi; pfam02517 498214009847 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 498214009848 G1 box; other site 498214009849 GTP/Mg2+ binding site [chemical binding]; other site 498214009850 Switch I region; other site 498214009851 G2 box; other site 498214009852 G3 box; other site 498214009853 Switch II region; other site 498214009854 G4 box; other site 498214009855 G5 box; other site 498214009856 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 498214009857 Found in ATP-dependent protease La (LON); Region: LON; smart00464 498214009858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214009859 Walker A motif; other site 498214009860 ATP binding site [chemical binding]; other site 498214009861 Walker B motif; other site 498214009862 arginine finger; other site 498214009863 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 498214009864 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 498214009865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214009866 Walker A motif; other site 498214009867 ATP binding site [chemical binding]; other site 498214009868 Walker B motif; other site 498214009869 arginine finger; other site 498214009870 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 498214009871 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 498214009872 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 498214009873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214009874 Walker A motif; other site 498214009875 ATP binding site [chemical binding]; other site 498214009876 Walker B motif; other site 498214009877 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 498214009878 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 498214009879 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 498214009880 oligomer interface [polypeptide binding]; other site 498214009881 active site residues [active] 498214009882 trigger factor; Provisional; Region: tig; PRK01490 498214009883 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 498214009884 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 498214009885 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 498214009886 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 498214009887 DNA interaction; other site 498214009888 Metal-binding active site; metal-binding site 498214009889 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498214009890 active site 498214009891 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 498214009892 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 498214009893 heterodimer interface [polypeptide binding]; other site 498214009894 active site 498214009895 FMN binding site [chemical binding]; other site 498214009896 homodimer interface [polypeptide binding]; other site 498214009897 substrate binding site [chemical binding]; other site 498214009898 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 498214009899 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 498214009900 FAD binding pocket [chemical binding]; other site 498214009901 FAD binding motif [chemical binding]; other site 498214009902 phosphate binding motif [ion binding]; other site 498214009903 beta-alpha-beta structure motif; other site 498214009904 NAD binding pocket [chemical binding]; other site 498214009905 Iron coordination center [ion binding]; other site 498214009906 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 498214009907 active site 498214009908 dimer interface [polypeptide binding]; other site 498214009909 dihydroorotase; Validated; Region: pyrC; PRK09357 498214009910 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 498214009911 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 498214009912 active site 498214009913 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 498214009914 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 498214009915 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 498214009916 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 498214009917 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 498214009918 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 498214009919 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 498214009920 nucleotide binding site [chemical binding]; other site 498214009921 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 498214009922 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 498214009923 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 498214009924 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 498214009925 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 498214009926 DsrE/DsrF-like family; Region: DrsE; cl00672 498214009927 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 498214009928 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 498214009929 Walker A/P-loop; other site 498214009930 ATP binding site [chemical binding]; other site 498214009931 Q-loop/lid; other site 498214009932 ABC transporter signature motif; other site 498214009933 Walker B; other site 498214009934 D-loop; other site 498214009935 H-loop/switch region; other site 498214009936 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 498214009937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 498214009938 dimer interface [polypeptide binding]; other site 498214009939 conserved gate region; other site 498214009940 ABC-ATPase subunit interface; other site 498214009941 NMT1-like family; Region: NMT1_2; pfam13379 498214009942 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 498214009943 Predicted permeases [General function prediction only]; Region: COG0701 498214009944 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 498214009945 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 498214009946 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 498214009947 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 498214009948 active site 498214009949 metal binding site [ion binding]; metal-binding site 498214009950 homotetramer interface [polypeptide binding]; other site 498214009951 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 498214009952 active site 498214009953 dimerization interface [polypeptide binding]; other site 498214009954 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 498214009955 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 498214009956 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 498214009957 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 498214009958 GatB domain; Region: GatB_Yqey; smart00845 498214009959 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 498214009960 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 498214009961 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 498214009962 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 498214009963 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 498214009964 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 498214009965 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 498214009966 nucleotide binding pocket [chemical binding]; other site 498214009967 K-X-D-G motif; other site 498214009968 catalytic site [active] 498214009969 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 498214009970 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 498214009971 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 498214009972 DNA binding site [nucleotide binding] 498214009973 metal binding site [ion binding]; metal-binding site 498214009974 Helix-hairpin-helix motif; Region: HHH; pfam00633 498214009975 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 498214009976 Dimer interface [polypeptide binding]; other site 498214009977 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 498214009978 Part of AAA domain; Region: AAA_19; pfam13245 498214009979 Family description; Region: UvrD_C_2; pfam13538 498214009980 Trp repressor protein; Region: Trp_repressor; cl17266 498214009981 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 498214009982 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 498214009983 RNA binding surface [nucleotide binding]; other site 498214009984 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 498214009985 active site 498214009986 uracil binding [chemical binding]; other site 498214009987 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 498214009988 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 498214009989 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 498214009990 N-acetyl-D-glucosamine binding site [chemical binding]; other site 498214009991 catalytic residue [active] 498214009992 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 498214009993 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 498214009994 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 498214009995 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 498214009996 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 498214009997 hypothetical protein; Validated; Region: PRK00124 498214009998 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 498214009999 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 498214010000 active site 498214010001 dimer interface [polypeptide binding]; other site 498214010002 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 498214010003 dimer interface [polypeptide binding]; other site 498214010004 active site 498214010005 Probable zinc-binding domain; Region: zf-trcl; pfam13451 498214010006 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 498214010007 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 498214010008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214010009 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 498214010010 Coenzyme A binding pocket [chemical binding]; other site 498214010011 D-lactate dehydrogenase; Validated; Region: PRK08605 498214010012 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 498214010013 homodimer interface [polypeptide binding]; other site 498214010014 ligand binding site [chemical binding]; other site 498214010015 NAD binding site [chemical binding]; other site 498214010016 catalytic site [active] 498214010017 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 498214010018 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 498214010019 putative ligand binding site [chemical binding]; other site 498214010020 putative NAD binding site [chemical binding]; other site 498214010021 catalytic site [active] 498214010022 Uncharacterized membrane protein [Function unknown]; Region: COG3949 498214010023 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 498214010024 4Fe-4S binding domain; Region: Fer4; pfam00037 498214010025 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 498214010026 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 498214010027 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 498214010028 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 498214010029 Ligand binding site [chemical binding]; other site 498214010030 Electron transfer flavoprotein domain; Region: ETF; pfam01012 498214010031 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 498214010032 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 498214010033 active site 498214010034 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 498214010035 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 498214010036 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 498214010037 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 498214010038 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 498214010039 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 498214010040 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 498214010041 CoA-transferase family III; Region: CoA_transf_3; pfam02515 498214010042 AMP-binding domain protein; Validated; Region: PRK08315 498214010043 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 498214010044 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 498214010045 acyl-activating enzyme (AAE) consensus motif; other site 498214010046 putative AMP binding site [chemical binding]; other site 498214010047 putative active site [active] 498214010048 putative CoA binding site [chemical binding]; other site 498214010049 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 498214010050 GMP synthase; Reviewed; Region: guaA; PRK00074 498214010051 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 498214010052 AMP/PPi binding site [chemical binding]; other site 498214010053 candidate oxyanion hole; other site 498214010054 catalytic triad [active] 498214010055 potential glutamine specificity residues [chemical binding]; other site 498214010056 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 498214010057 ATP Binding subdomain [chemical binding]; other site 498214010058 Ligand Binding sites [chemical binding]; other site 498214010059 Dimerization subdomain; other site 498214010060 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 498214010061 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 498214010062 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 498214010063 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 498214010064 active site 498214010065 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 498214010066 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 498214010067 Ligand Binding Site [chemical binding]; other site 498214010068 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 498214010069 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 498214010070 ring oligomerisation interface [polypeptide binding]; other site 498214010071 ATP/Mg binding site [chemical binding]; other site 498214010072 stacking interactions; other site 498214010073 hinge regions; other site 498214010074 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 498214010075 oligomerisation interface [polypeptide binding]; other site 498214010076 mobile loop; other site 498214010077 roof hairpin; other site 498214010078 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 498214010079 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 498214010080 4Fe-4S binding domain; Region: Fer4; pfam00037 498214010081 4Fe-4S binding domain; Region: Fer4; pfam00037 498214010082 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 498214010083 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 498214010084 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 498214010085 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 498214010086 minor groove reading motif; other site 498214010087 helix-hairpin-helix signature motif; other site 498214010088 substrate binding pocket [chemical binding]; other site 498214010089 active site 498214010090 putative oxidoreductase; Provisional; Region: PRK12831 498214010091 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 498214010092 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 498214010093 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 498214010094 FAD binding pocket [chemical binding]; other site 498214010095 FAD binding motif [chemical binding]; other site 498214010096 phosphate binding motif [ion binding]; other site 498214010097 beta-alpha-beta structure motif; other site 498214010098 NAD binding pocket [chemical binding]; other site 498214010099 Iron coordination center [ion binding]; other site 498214010100 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 498214010101 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 498214010102 CoA binding domain; Region: CoA_binding; pfam02629 498214010103 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 498214010104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214010105 Walker A/P-loop; other site 498214010106 ATP binding site [chemical binding]; other site 498214010107 Q-loop/lid; other site 498214010108 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498214010109 ABC transporter; Region: ABC_tran_2; pfam12848 498214010110 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 498214010111 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 498214010112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214010113 active site 498214010114 phosphorylation site [posttranslational modification] 498214010115 intermolecular recognition site; other site 498214010116 dimerization interface [polypeptide binding]; other site 498214010117 LytTr DNA-binding domain; Region: LytTR; pfam04397 498214010118 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 498214010119 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 498214010120 Histidine kinase; Region: His_kinase; pfam06580 498214010121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214010122 ATP binding site [chemical binding]; other site 498214010123 Mg2+ binding site [ion binding]; other site 498214010124 G-X-G motif; other site 498214010125 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 498214010126 Carbon starvation protein CstA; Region: CstA; pfam02554 498214010127 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 498214010128 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 498214010129 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 498214010130 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 498214010131 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 498214010132 Peptidase M16C associated; Region: M16C_assoc; pfam08367 498214010133 pyruvate carboxylase; Reviewed; Region: PRK12999 498214010134 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 498214010135 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 498214010136 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 498214010137 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 498214010138 active site 498214010139 catalytic residues [active] 498214010140 metal binding site [ion binding]; metal-binding site 498214010141 homodimer binding site [polypeptide binding]; other site 498214010142 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 498214010143 carboxyltransferase (CT) interaction site; other site 498214010144 biotinylation site [posttranslational modification]; other site 498214010145 UGMP family protein; Validated; Region: PRK09604 498214010146 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 498214010147 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 498214010148 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 498214010149 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 498214010150 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 498214010151 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 498214010152 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 498214010153 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 498214010154 intersubunit interface [polypeptide binding]; other site 498214010155 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214010156 Zn2+ binding site [ion binding]; other site 498214010157 Mg2+ binding site [ion binding]; other site 498214010158 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 498214010159 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214010160 Zn2+ binding site [ion binding]; other site 498214010161 Mg2+ binding site [ion binding]; other site 498214010162 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 498214010163 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 498214010164 Glycoprotease family; Region: Peptidase_M22; pfam00814 498214010165 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 498214010166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214010167 Coenzyme A binding pocket [chemical binding]; other site 498214010168 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 498214010169 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 498214010170 active site 498214010171 HIGH motif; other site 498214010172 dimer interface [polypeptide binding]; other site 498214010173 KMSKS motif; other site 498214010174 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 498214010175 RNA binding surface [nucleotide binding]; other site 498214010176 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 498214010177 Divergent AAA domain; Region: AAA_4; pfam04326 498214010178 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 498214010179 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 498214010180 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 498214010181 active site 498214010182 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 498214010183 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 498214010184 G1 box; other site 498214010185 putative GEF interaction site [polypeptide binding]; other site 498214010186 GTP/Mg2+ binding site [chemical binding]; other site 498214010187 Switch I region; other site 498214010188 G2 box; other site 498214010189 G3 box; other site 498214010190 Switch II region; other site 498214010191 G4 box; other site 498214010192 G5 box; other site 498214010193 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 498214010194 sugar phosphate phosphatase; Provisional; Region: PRK10513 498214010195 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498214010196 active site 498214010197 motif I; other site 498214010198 motif II; other site 498214010199 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 498214010200 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 498214010201 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 498214010202 active site 498214010203 HIGH motif; other site 498214010204 dimer interface [polypeptide binding]; other site 498214010205 KMSKS motif; other site 498214010206 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 498214010207 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 498214010208 non-heme iron binding site [ion binding]; other site 498214010209 dimer interface [polypeptide binding]; other site 498214010210 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 498214010211 non-heme iron binding site [ion binding]; other site 498214010212 dimer interface [polypeptide binding]; other site 498214010213 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 498214010214 Putative glucoamylase; Region: Glycoamylase; pfam10091 498214010215 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 498214010216 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 498214010217 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 498214010218 diaminopimelate decarboxylase; Region: lysA; TIGR01048 498214010219 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 498214010220 active site 498214010221 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 498214010222 substrate binding site [chemical binding]; other site 498214010223 catalytic residues [active] 498214010224 dimer interface [polypeptide binding]; other site 498214010225 aspartate kinase; Reviewed; Region: PRK06635 498214010226 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 498214010227 putative nucleotide binding site [chemical binding]; other site 498214010228 putative catalytic residues [active] 498214010229 putative Mg ion binding site [ion binding]; other site 498214010230 putative aspartate binding site [chemical binding]; other site 498214010231 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 498214010232 putative allosteric regulatory site; other site 498214010233 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 498214010234 putative allosteric regulatory residue; other site 498214010235 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 498214010236 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 498214010237 active site 498214010238 metal binding site [ion binding]; metal-binding site 498214010239 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 498214010240 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 498214010241 hypothetical protein; Provisional; Region: PRK06851 498214010242 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 498214010243 Part of AAA domain; Region: AAA_19; pfam13245 498214010244 FtsH Extracellular; Region: FtsH_ext; pfam06480 498214010245 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 498214010246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214010247 Walker A motif; other site 498214010248 ATP binding site [chemical binding]; other site 498214010249 Walker B motif; other site 498214010250 arginine finger; other site 498214010251 Peptidase family M41; Region: Peptidase_M41; pfam01434 498214010252 dipeptidase PepV; Reviewed; Region: PRK07318 498214010253 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 498214010254 active site 498214010255 metal binding site [ion binding]; metal-binding site 498214010256 prolyl-tRNA synthetase; Provisional; Region: PRK08661 498214010257 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 498214010258 dimer interface [polypeptide binding]; other site 498214010259 motif 1; other site 498214010260 active site 498214010261 motif 2; other site 498214010262 motif 3; other site 498214010263 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 498214010264 anticodon binding site; other site 498214010265 zinc-binding site [ion binding]; other site 498214010266 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 498214010267 GIY-YIG motif/motif A; other site 498214010268 putative active site [active] 498214010269 putative metal binding site [ion binding]; other site 498214010270 putative transporter; Provisional; Region: PRK11660 498214010271 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 498214010272 Sulfate transporter family; Region: Sulfate_transp; pfam00916 498214010273 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 498214010274 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214010275 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214010276 dimer interface [polypeptide binding]; other site 498214010277 phosphorylation site [posttranslational modification] 498214010278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214010279 ATP binding site [chemical binding]; other site 498214010280 Mg2+ binding site [ion binding]; other site 498214010281 G-X-G motif; other site 498214010282 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214010283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214010284 active site 498214010285 phosphorylation site [posttranslational modification] 498214010286 intermolecular recognition site; other site 498214010287 dimerization interface [polypeptide binding]; other site 498214010288 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214010289 DNA binding site [nucleotide binding] 498214010290 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 498214010291 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 498214010292 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 498214010293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214010294 Walker A/P-loop; other site 498214010295 ATP binding site [chemical binding]; other site 498214010296 Q-loop/lid; other site 498214010297 ABC transporter signature motif; other site 498214010298 Walker B; other site 498214010299 D-loop; other site 498214010300 H-loop/switch region; other site 498214010301 Uncharacterized conserved protein [Function unknown]; Region: COG3589 498214010302 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 498214010303 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 498214010304 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 498214010305 methionine cluster; other site 498214010306 active site 498214010307 phosphorylation site [posttranslational modification] 498214010308 metal binding site [ion binding]; metal-binding site 498214010309 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 498214010310 active site 498214010311 P-loop; other site 498214010312 phosphorylation site [posttranslational modification] 498214010313 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 498214010314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214010315 Walker A motif; other site 498214010316 ATP binding site [chemical binding]; other site 498214010317 Walker B motif; other site 498214010318 arginine finger; other site 498214010319 Transcriptional antiterminator [Transcription]; Region: COG3933 498214010320 PRD domain; Region: PRD; pfam00874 498214010321 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 498214010322 active pocket/dimerization site; other site 498214010323 active site 498214010324 phosphorylation site [posttranslational modification] 498214010325 PRD domain; Region: PRD; pfam00874 498214010326 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 498214010327 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 498214010328 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 498214010329 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 498214010330 NAD binding site [chemical binding]; other site 498214010331 sugar binding site [chemical binding]; other site 498214010332 divalent metal binding site [ion binding]; other site 498214010333 tetramer (dimer of dimers) interface [polypeptide binding]; other site 498214010334 dimer interface [polypeptide binding]; other site 498214010335 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 498214010336 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 498214010337 metal binding site [ion binding]; metal-binding site 498214010338 active site 498214010339 I-site; other site 498214010340 Phage integrase family; Region: Phage_integrase; pfam00589 498214010341 active site 498214010342 DNA binding site [nucleotide binding] 498214010343 Int/Topo IB signature motif; other site 498214010344 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 498214010345 Protein of unknown function DUF43; Region: DUF43; pfam01861 498214010346 Mor transcription activator family; Region: Mor; cl02360 498214010347 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 498214010348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214010349 Coenzyme A binding pocket [chemical binding]; other site 498214010350 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 498214010351 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 498214010352 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214010353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214010354 S-adenosylmethionine binding site [chemical binding]; other site 498214010355 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 498214010356 active site 498214010357 catalytic motif [active] 498214010358 Zn binding site [ion binding]; other site 498214010359 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 498214010360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 498214010361 NAD(P) binding site [chemical binding]; other site 498214010362 active site 498214010363 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 498214010364 RibD C-terminal domain; Region: RibD_C; cl17279 498214010365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214010366 Walker A/P-loop; other site 498214010367 ATP binding site [chemical binding]; other site 498214010368 Q-loop/lid; other site 498214010369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214010370 ABC transporter signature motif; other site 498214010371 Walker B; other site 498214010372 D-loop; other site 498214010373 H-loop/switch region; other site 498214010374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214010375 Walker A/P-loop; other site 498214010376 ATP binding site [chemical binding]; other site 498214010377 Q-loop/lid; other site 498214010378 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 498214010379 ABC transporter signature motif; other site 498214010380 Walker B; other site 498214010381 D-loop; other site 498214010382 H-loop/switch region; other site 498214010383 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 498214010384 dimerization interface [polypeptide binding]; other site 498214010385 putative Zn2+ binding site [ion binding]; other site 498214010386 putative DNA binding site [nucleotide binding]; other site 498214010387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 498214010388 Protein of unknown function, DUF606; Region: DUF606; pfam04657 498214010389 Rrf2 family protein; Region: rrf2_super; TIGR00738 498214010390 Transcriptional regulator; Region: Rrf2; pfam02082 498214010391 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 498214010392 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 498214010393 Coenzyme A binding pocket [chemical binding]; other site 498214010394 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 498214010395 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 498214010396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 498214010397 S-adenosylmethionine binding site [chemical binding]; other site 498214010398 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 498214010399 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 498214010400 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 498214010401 active site 498214010402 catalytic tetrad [active] 498214010403 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 498214010404 pyruvate kinase; Provisional; Region: PRK06354 498214010405 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 498214010406 domain interfaces; other site 498214010407 active site 498214010408 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 498214010409 6-phosphofructokinase; Provisional; Region: PRK03202 498214010410 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 498214010411 active site 498214010412 ADP/pyrophosphate binding site [chemical binding]; other site 498214010413 dimerization interface [polypeptide binding]; other site 498214010414 allosteric effector site; other site 498214010415 fructose-1,6-bisphosphate binding site; other site 498214010416 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 498214010417 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 498214010418 active site 498214010419 PHP Thumb interface [polypeptide binding]; other site 498214010420 metal binding site [ion binding]; metal-binding site 498214010421 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 498214010422 generic binding surface II; other site 498214010423 generic binding surface I; other site 498214010424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 498214010425 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 498214010426 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 498214010427 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 498214010428 phosphate binding site [ion binding]; other site 498214010429 putative substrate binding pocket [chemical binding]; other site 498214010430 dimer interface [polypeptide binding]; other site 498214010431 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 498214010432 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 498214010433 FAD binding domain; Region: FAD_binding_4; pfam01565 498214010434 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 498214010435 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 498214010436 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 498214010437 active site 498214010438 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 498214010439 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 498214010440 GIY-YIG motif/motif A; other site 498214010441 active site 498214010442 catalytic site [active] 498214010443 putative DNA binding site [nucleotide binding]; other site 498214010444 metal binding site [ion binding]; metal-binding site 498214010445 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 498214010446 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 498214010447 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 498214010448 generic binding surface II; other site 498214010449 generic binding surface I; other site 498214010450 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 498214010451 Zn2+ binding site [ion binding]; other site 498214010452 Mg2+ binding site [ion binding]; other site 498214010453 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 498214010454 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 498214010455 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 498214010456 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 498214010457 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 498214010458 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 498214010459 phosphopeptide binding site; other site 498214010460 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 498214010461 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 498214010462 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 498214010463 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 498214010464 excinuclease ABC subunit B; Provisional; Region: PRK05298 498214010465 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498214010466 ATP binding site [chemical binding]; other site 498214010467 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498214010468 nucleotide binding region [chemical binding]; other site 498214010469 ATP-binding site [chemical binding]; other site 498214010470 Ultra-violet resistance protein B; Region: UvrB; pfam12344 498214010471 UvrB/uvrC motif; Region: UVR; pfam02151 498214010472 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 498214010473 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 498214010474 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 498214010475 C-terminal peptidase (prc); Region: prc; TIGR00225 498214010476 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 498214010477 protein binding site [polypeptide binding]; other site 498214010478 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 498214010479 Catalytic dyad [active] 498214010480 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 498214010481 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 498214010482 FtsX-like permease family; Region: FtsX; pfam02687 498214010483 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 498214010484 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 498214010485 Walker A/P-loop; other site 498214010486 ATP binding site [chemical binding]; other site 498214010487 Q-loop/lid; other site 498214010488 ABC transporter signature motif; other site 498214010489 Walker B; other site 498214010490 D-loop; other site 498214010491 H-loop/switch region; other site 498214010492 Uncharacterized conserved protein [Function unknown]; Region: COG1284 498214010493 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 498214010494 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 498214010495 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 498214010496 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 498214010497 PYR/PP interface [polypeptide binding]; other site 498214010498 dimer interface [polypeptide binding]; other site 498214010499 TPP binding site [chemical binding]; other site 498214010500 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 498214010501 transketolase; Reviewed; Region: PRK05899 498214010502 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 498214010503 TPP-binding site [chemical binding]; other site 498214010504 dimer interface [polypeptide binding]; other site 498214010505 PemK-like protein; Region: PemK; pfam02452 498214010506 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 498214010507 alanine racemase; Reviewed; Region: alr; PRK00053 498214010508 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 498214010509 active site 498214010510 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 498214010511 dimer interface [polypeptide binding]; other site 498214010512 substrate binding site [chemical binding]; other site 498214010513 catalytic residues [active] 498214010514 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 498214010515 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 498214010516 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 498214010517 putative substrate binding site [chemical binding]; other site 498214010518 putative ATP binding site [chemical binding]; other site 498214010519 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 498214010520 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 498214010521 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 498214010522 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 498214010523 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 498214010524 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 498214010525 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 498214010526 RNA binding surface [nucleotide binding]; other site 498214010527 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 498214010528 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 498214010529 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 498214010530 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 498214010531 active site 498214010532 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 498214010533 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 498214010534 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214010535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214010536 dimerization interface [polypeptide binding]; other site 498214010537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214010538 dimer interface [polypeptide binding]; other site 498214010539 phosphorylation site [posttranslational modification] 498214010540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214010541 ATP binding site [chemical binding]; other site 498214010542 Mg2+ binding site [ion binding]; other site 498214010543 G-X-G motif; other site 498214010544 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214010545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214010546 active site 498214010547 phosphorylation site [posttranslational modification] 498214010548 intermolecular recognition site; other site 498214010549 dimerization interface [polypeptide binding]; other site 498214010550 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214010551 DNA binding site [nucleotide binding] 498214010552 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 498214010553 dinuclear metal binding motif [ion binding]; other site 498214010554 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 498214010555 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 498214010556 DNA binding residues [nucleotide binding] 498214010557 drug binding residues [chemical binding]; other site 498214010558 dimer interface [polypeptide binding]; other site 498214010559 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 498214010560 Creatinine amidohydrolase; Region: Creatininase; pfam02633 498214010561 Protein of unknown function DUF262; Region: DUF262; pfam03235 498214010562 Methyltransferase domain; Region: Methyltransf_26; pfam13659 498214010563 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 498214010564 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 498214010565 glutaminase active site [active] 498214010566 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 498214010567 dimer interface [polypeptide binding]; other site 498214010568 active site 498214010569 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 498214010570 dimer interface [polypeptide binding]; other site 498214010571 active site 498214010572 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 498214010573 active site 498214010574 intersubunit interactions; other site 498214010575 catalytic residue [active] 498214010576 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 498214010577 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498214010578 motif II; other site 498214010579 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 498214010580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 498214010581 NAD(P) binding site [chemical binding]; other site 498214010582 active site 498214010583 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 498214010584 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 498214010585 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 498214010586 Nucleoside recognition; Region: Gate; pfam07670 498214010587 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 498214010588 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 498214010589 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 498214010590 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 498214010591 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 498214010592 putative NAD(P) binding site [chemical binding]; other site 498214010593 catalytic Zn binding site [ion binding]; other site 498214010594 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 498214010595 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 498214010596 non-specific DNA interactions [nucleotide binding]; other site 498214010597 DNA binding site [nucleotide binding] 498214010598 sequence specific DNA binding site [nucleotide binding]; other site 498214010599 putative cAMP binding site [chemical binding]; other site 498214010600 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 498214010601 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 498214010602 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 498214010603 active site 498214010604 substrate binding site [chemical binding]; other site 498214010605 metal binding site [ion binding]; metal-binding site 498214010606 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 498214010607 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 498214010608 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 498214010609 TPP-binding site [chemical binding]; other site 498214010610 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 498214010611 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 498214010612 dimer interface [polypeptide binding]; other site 498214010613 PYR/PP interface [polypeptide binding]; other site 498214010614 TPP binding site [chemical binding]; other site 498214010615 substrate binding site [chemical binding]; other site 498214010616 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 498214010617 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 498214010618 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 498214010619 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 498214010620 P-loop; other site 498214010621 Magnesium ion binding site [ion binding]; other site 498214010622 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 498214010623 nucleotide binding site [chemical binding]; other site 498214010624 Acetokinase family; Region: Acetate_kinase; cl17229 498214010625 phosphate butyryltransferase; Validated; Region: PRK05805 498214010626 butyrate kinase; Provisional; Region: PRK03011 498214010627 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 498214010628 YbbR-like protein; Region: YbbR; pfam07949 498214010629 YbbR-like protein; Region: YbbR; pfam07949 498214010630 Uncharacterized conserved protein [Function unknown]; Region: COG1624 498214010631 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 498214010632 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 498214010633 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 498214010634 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 498214010635 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 498214010636 catalytic residues [active] 498214010637 isoaspartyl dipeptidase; Provisional; Region: PRK10657 498214010638 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 498214010639 active site 498214010640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 498214010641 TPR motif; other site 498214010642 TPR repeat; Region: TPR_11; pfam13414 498214010643 binding surface 498214010644 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 498214010645 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 498214010646 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 498214010647 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 498214010648 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 498214010649 dimerization domain swap beta strand [polypeptide binding]; other site 498214010650 regulatory protein interface [polypeptide binding]; other site 498214010651 active site 498214010652 regulatory phosphorylation site [posttranslational modification]; other site 498214010653 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 498214010654 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498214010655 putative active site [active] 498214010656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 498214010657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214010658 Walker A motif; other site 498214010659 ATP binding site [chemical binding]; other site 498214010660 Walker B motif; other site 498214010661 arginine finger; other site 498214010662 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 498214010663 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 498214010664 TPR motif; other site 498214010665 binding surface 498214010666 Tetratricopeptide repeat; Region: TPR_12; pfam13424 498214010667 fumarate hydratase; Provisional; Region: PRK06842 498214010668 fumarate hydratase; Provisional; Region: PRK06246 498214010669 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 498214010670 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 498214010671 active site 498214010672 metal binding site [ion binding]; metal-binding site 498214010673 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 498214010674 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 498214010675 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 498214010676 PhoU domain; Region: PhoU; pfam01895 498214010677 PhoU domain; Region: PhoU; pfam01895 498214010678 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 498214010679 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 498214010680 23S rRNA interface [nucleotide binding]; other site 498214010681 L3 interface [polypeptide binding]; other site 498214010682 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 498214010683 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 498214010684 dimerization interface 3.5A [polypeptide binding]; other site 498214010685 active site 498214010686 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 498214010687 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 498214010688 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 498214010689 Walker A/P-loop; other site 498214010690 ATP binding site [chemical binding]; other site 498214010691 Q-loop/lid; other site 498214010692 ABC transporter signature motif; other site 498214010693 Walker B; other site 498214010694 D-loop; other site 498214010695 H-loop/switch region; other site 498214010696 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 498214010697 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 498214010698 Walker A/P-loop; other site 498214010699 ATP binding site [chemical binding]; other site 498214010700 Q-loop/lid; other site 498214010701 ABC transporter signature motif; other site 498214010702 Walker B; other site 498214010703 D-loop; other site 498214010704 H-loop/switch region; other site 498214010705 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 498214010706 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 498214010707 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 498214010708 alphaNTD homodimer interface [polypeptide binding]; other site 498214010709 alphaNTD - beta interaction site [polypeptide binding]; other site 498214010710 alphaNTD - beta' interaction site [polypeptide binding]; other site 498214010711 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 498214010712 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 498214010713 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 498214010714 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 498214010715 RNA binding surface [nucleotide binding]; other site 498214010716 30S ribosomal protein S11; Validated; Region: PRK05309 498214010717 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 498214010718 30S ribosomal protein S13; Region: bact_S13; TIGR03631 498214010719 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 498214010720 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 498214010721 rRNA binding site [nucleotide binding]; other site 498214010722 predicted 30S ribosome binding site; other site 498214010723 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 498214010724 RNA binding site [nucleotide binding]; other site 498214010725 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 498214010726 active site 498214010727 adenylate kinase; Reviewed; Region: adk; PRK00279 498214010728 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 498214010729 AMP-binding site [chemical binding]; other site 498214010730 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 498214010731 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 498214010732 SecY translocase; Region: SecY; pfam00344 498214010733 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 498214010734 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 498214010735 23S rRNA binding site [nucleotide binding]; other site 498214010736 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 498214010737 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 498214010738 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 498214010739 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 498214010740 5S rRNA interface [nucleotide binding]; other site 498214010741 L27 interface [polypeptide binding]; other site 498214010742 23S rRNA interface [nucleotide binding]; other site 498214010743 L5 interface [polypeptide binding]; other site 498214010744 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 498214010745 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 498214010746 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 498214010747 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 498214010748 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 498214010749 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 498214010750 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 498214010751 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 498214010752 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 498214010753 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 498214010754 RNA binding site [nucleotide binding]; other site 498214010755 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 498214010756 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 498214010757 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 498214010758 23S rRNA interface [nucleotide binding]; other site 498214010759 putative translocon interaction site; other site 498214010760 signal recognition particle (SRP54) interaction site; other site 498214010761 L23 interface [polypeptide binding]; other site 498214010762 trigger factor interaction site; other site 498214010763 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 498214010764 23S rRNA interface [nucleotide binding]; other site 498214010765 5S rRNA interface [nucleotide binding]; other site 498214010766 putative antibiotic binding site [chemical binding]; other site 498214010767 L25 interface [polypeptide binding]; other site 498214010768 L27 interface [polypeptide binding]; other site 498214010769 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 498214010770 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 498214010771 G-X-X-G motif; other site 498214010772 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 498214010773 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 498214010774 putative translocon binding site; other site 498214010775 protein-rRNA interface [nucleotide binding]; other site 498214010776 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 498214010777 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 498214010778 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 498214010779 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 498214010780 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 498214010781 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 498214010782 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 498214010783 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 498214010784 elongation factor Tu; Reviewed; Region: PRK00049 498214010785 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 498214010786 G1 box; other site 498214010787 GEF interaction site [polypeptide binding]; other site 498214010788 GTP/Mg2+ binding site [chemical binding]; other site 498214010789 Switch I region; other site 498214010790 G2 box; other site 498214010791 G3 box; other site 498214010792 Switch II region; other site 498214010793 G4 box; other site 498214010794 G5 box; other site 498214010795 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 498214010796 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 498214010797 Antibiotic Binding Site [chemical binding]; other site 498214010798 elongation factor G; Reviewed; Region: PRK00007 498214010799 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 498214010800 G1 box; other site 498214010801 putative GEF interaction site [polypeptide binding]; other site 498214010802 GTP/Mg2+ binding site [chemical binding]; other site 498214010803 Switch I region; other site 498214010804 G2 box; other site 498214010805 G3 box; other site 498214010806 Switch II region; other site 498214010807 G4 box; other site 498214010808 G5 box; other site 498214010809 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 498214010810 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 498214010811 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 498214010812 30S ribosomal protein S7; Validated; Region: PRK05302 498214010813 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 498214010814 S17 interaction site [polypeptide binding]; other site 498214010815 S8 interaction site; other site 498214010816 16S rRNA interaction site [nucleotide binding]; other site 498214010817 streptomycin interaction site [chemical binding]; other site 498214010818 23S rRNA interaction site [nucleotide binding]; other site 498214010819 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 498214010820 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 498214010821 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 498214010822 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 498214010823 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 498214010824 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 498214010825 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 498214010826 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 498214010827 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 498214010828 G-loop; other site 498214010829 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 498214010830 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 498214010831 DNA binding site [nucleotide binding] 498214010832 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 498214010833 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 498214010834 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 498214010835 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 498214010836 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 498214010837 RPB1 interaction site [polypeptide binding]; other site 498214010838 RPB10 interaction site [polypeptide binding]; other site 498214010839 RPB11 interaction site [polypeptide binding]; other site 498214010840 RPB3 interaction site [polypeptide binding]; other site 498214010841 RPB12 interaction site [polypeptide binding]; other site 498214010842 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 498214010843 core dimer interface [polypeptide binding]; other site 498214010844 peripheral dimer interface [polypeptide binding]; other site 498214010845 L10 interface [polypeptide binding]; other site 498214010846 L11 interface [polypeptide binding]; other site 498214010847 putative EF-Tu interaction site [polypeptide binding]; other site 498214010848 putative EF-G interaction site [polypeptide binding]; other site 498214010849 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 498214010850 23S rRNA interface [nucleotide binding]; other site 498214010851 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 498214010852 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 498214010853 mRNA/rRNA interface [nucleotide binding]; other site 498214010854 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 498214010855 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 498214010856 23S rRNA interface [nucleotide binding]; other site 498214010857 L7/L12 interface [polypeptide binding]; other site 498214010858 putative thiostrepton binding site; other site 498214010859 L25 interface [polypeptide binding]; other site 498214010860 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 498214010861 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 498214010862 putative homodimer interface [polypeptide binding]; other site 498214010863 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 498214010864 heterodimer interface [polypeptide binding]; other site 498214010865 homodimer interface [polypeptide binding]; other site 498214010866 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 498214010867 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 498214010868 elongation factor Tu; Reviewed; Region: PRK00049 498214010869 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 498214010870 G1 box; other site 498214010871 GEF interaction site [polypeptide binding]; other site 498214010872 GTP/Mg2+ binding site [chemical binding]; other site 498214010873 Switch I region; other site 498214010874 G2 box; other site 498214010875 G3 box; other site 498214010876 Switch II region; other site 498214010877 G4 box; other site 498214010878 G5 box; other site 498214010879 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 498214010880 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 498214010881 Antibiotic Binding Site [chemical binding]; other site 498214010882 RNA polymerase factor sigma-70; Validated; Region: PRK08295 498214010883 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 498214010884 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 498214010885 YacP-like NYN domain; Region: NYN_YacP; pfam05991 498214010886 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 498214010887 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 498214010888 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 498214010889 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 498214010890 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 498214010891 dimerization interface [polypeptide binding]; other site 498214010892 active site 498214010893 metal binding site [ion binding]; metal-binding site 498214010894 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 498214010895 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 498214010896 active site 498214010897 HIGH motif; other site 498214010898 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 498214010899 KMSKS motif; other site 498214010900 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 498214010901 tRNA binding surface [nucleotide binding]; other site 498214010902 anticodon binding site; other site 498214010903 threonine dehydratase; Provisional; Region: PRK08198 498214010904 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 498214010905 tetramer interface [polypeptide binding]; other site 498214010906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 498214010907 catalytic residue [active] 498214010908 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 498214010909 prolyl-tRNA synthetase; Provisional; Region: PRK09194 498214010910 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 498214010911 motif 1; other site 498214010912 dimer interface [polypeptide binding]; other site 498214010913 motif 2; other site 498214010914 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 498214010915 putative deacylase active site [active] 498214010916 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 498214010917 anticodon binding site; other site 498214010918 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 498214010919 substrate binding site; other site 498214010920 dimer interface; other site 498214010921 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 498214010922 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 498214010923 putative active site [active] 498214010924 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 498214010925 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 498214010926 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 498214010927 DNA repair protein RadA; Provisional; Region: PRK11823 498214010928 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 498214010929 Walker A motif/ATP binding site; other site 498214010930 ATP binding site [chemical binding]; other site 498214010931 Walker B motif; other site 498214010932 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 498214010933 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 498214010934 Clp amino terminal domain; Region: Clp_N; pfam02861 498214010935 Clp amino terminal domain; Region: Clp_N; pfam02861 498214010936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214010937 Walker A motif; other site 498214010938 ATP binding site [chemical binding]; other site 498214010939 Walker B motif; other site 498214010940 arginine finger; other site 498214010941 UvrB/uvrC motif; Region: UVR; pfam02151 498214010942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214010943 Walker A motif; other site 498214010944 ATP binding site [chemical binding]; other site 498214010945 Walker B motif; other site 498214010946 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 498214010947 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 498214010948 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 498214010949 ADP binding site [chemical binding]; other site 498214010950 phosphagen binding site; other site 498214010951 substrate specificity loop; other site 498214010952 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 498214010953 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 498214010954 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 498214010955 elongation factor G; Reviewed; Region: PRK12740 498214010956 G1 box; other site 498214010957 putative GEF interaction site [polypeptide binding]; other site 498214010958 GTP/Mg2+ binding site [chemical binding]; other site 498214010959 Switch I region; other site 498214010960 G2 box; other site 498214010961 G3 box; other site 498214010962 Switch II region; other site 498214010963 G4 box; other site 498214010964 G5 box; other site 498214010965 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 498214010966 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 498214010967 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 498214010968 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 498214010969 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 498214010970 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 498214010971 Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729 498214010972 glycyl-tRNA synthetase; Provisional; Region: PRK04173 498214010973 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 498214010974 motif 1; other site 498214010975 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 498214010976 active site 498214010977 motif 2; other site 498214010978 motif 3; other site 498214010979 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 498214010980 anticodon binding site; other site 498214010981 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 498214010982 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 498214010983 dimer interface [polypeptide binding]; other site 498214010984 putative anticodon binding site; other site 498214010985 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 498214010986 motif 1; other site 498214010987 active site 498214010988 motif 2; other site 498214010989 motif 3; other site 498214010990 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 498214010991 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 498214010992 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 498214010993 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 498214010994 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 498214010995 FMN binding site [chemical binding]; other site 498214010996 active site 498214010997 catalytic residues [active] 498214010998 substrate binding site [chemical binding]; other site 498214010999 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 498214011000 nucleotide binding site [chemical binding]; other site 498214011001 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 498214011002 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 498214011003 Potassium binding sites [ion binding]; other site 498214011004 Cesium cation binding sites [ion binding]; other site 498214011005 FtsH Extracellular; Region: FtsH_ext; pfam06480 498214011006 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 498214011007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214011008 Walker A motif; other site 498214011009 ATP binding site [chemical binding]; other site 498214011010 Walker B motif; other site 498214011011 arginine finger; other site 498214011012 Peptidase family M41; Region: Peptidase_M41; pfam01434 498214011013 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498214011014 active site 498214011015 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 498214011016 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 498214011017 Ligand Binding Site [chemical binding]; other site 498214011018 TilS substrate C-terminal domain; Region: TilS_C; smart00977 498214011019 stage II sporulation protein E; Region: spore_II_E; TIGR02865 498214011020 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 498214011021 hypothetical protein; Provisional; Region: PRK05807 498214011022 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 498214011023 RNA binding site [nucleotide binding]; other site 498214011024 Septum formation initiator; Region: DivIC; pfam04977 498214011025 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 498214011026 sporulation protein YabP; Region: spore_yabP; TIGR02892 498214011027 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 498214011028 RNA binding surface [nucleotide binding]; other site 498214011029 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 498214011030 IHF dimer interface [polypeptide binding]; other site 498214011031 IHF - DNA interface [nucleotide binding]; other site 498214011032 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 498214011033 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 498214011034 putative SAM binding site [chemical binding]; other site 498214011035 putative homodimer interface [polypeptide binding]; other site 498214011036 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 498214011037 homodimer interface [polypeptide binding]; other site 498214011038 metal binding site [ion binding]; metal-binding site 498214011039 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 498214011040 homodimer interface [polypeptide binding]; other site 498214011041 active site 498214011042 putative chemical substrate binding site [chemical binding]; other site 498214011043 metal binding site [ion binding]; metal-binding site 498214011044 stage V sporulation protein B; Region: spore_V_B; TIGR02900 498214011045 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 498214011046 stage V sporulation protein T; Region: spore_V_T; TIGR02851 498214011047 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 498214011048 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 498214011049 SurA N-terminal domain; Region: SurA_N_3; cl07813 498214011050 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 498214011051 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 498214011052 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 498214011053 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 498214011054 ATP binding site [chemical binding]; other site 498214011055 putative Mg++ binding site [ion binding]; other site 498214011056 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 498214011057 nucleotide binding region [chemical binding]; other site 498214011058 ATP-binding site [chemical binding]; other site 498214011059 TRCF domain; Region: TRCF; pfam03461 498214011060 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 498214011061 putative active site [active] 498214011062 catalytic residue [active] 498214011063 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 498214011064 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 498214011065 protein binding site [polypeptide binding]; other site 498214011066 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 498214011067 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 498214011068 dimerization interface [polypeptide binding]; other site 498214011069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 498214011070 dimer interface [polypeptide binding]; other site 498214011071 phosphorylation site [posttranslational modification] 498214011072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 498214011073 ATP binding site [chemical binding]; other site 498214011074 Mg2+ binding site [ion binding]; other site 498214011075 G-X-G motif; other site 498214011076 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 498214011077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214011078 active site 498214011079 phosphorylation site [posttranslational modification] 498214011080 intermolecular recognition site; other site 498214011081 dimerization interface [polypeptide binding]; other site 498214011082 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 498214011083 DNA binding site [nucleotide binding] 498214011084 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 498214011085 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 498214011086 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498214011087 active site 498214011088 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 498214011089 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 498214011090 Substrate binding site; other site 498214011091 Mg++ binding site; other site 498214011092 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 498214011093 active site 498214011094 substrate binding site [chemical binding]; other site 498214011095 CoA binding site [chemical binding]; other site 498214011096 regulatory protein SpoVG; Reviewed; Region: PRK13259 498214011097 pur operon repressor; Provisional; Region: PRK09213 498214011098 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 498214011099 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 498214011100 active site 498214011101 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 498214011102 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 498214011103 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 498214011104 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 498214011105 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 498214011106 4Fe-4S binding domain; Region: Fer4; pfam00037 498214011107 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 498214011108 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 498214011109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 498214011110 motif II; other site 498214011111 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 498214011112 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 498214011113 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 498214011114 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214011115 FeS/SAM binding site; other site 498214011116 Uncharacterized membrane protein [Function unknown]; Region: COG3949 498214011117 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214011118 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 498214011119 FeS/SAM binding site; other site 498214011120 Heme NO binding; Region: HNOB; pfam07700 498214011121 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 498214011122 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 498214011123 dimer interface [polypeptide binding]; other site 498214011124 putative CheW interface [polypeptide binding]; other site 498214011125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 498214011126 non-specific DNA binding site [nucleotide binding]; other site 498214011127 salt bridge; other site 498214011128 sequence-specific DNA binding site [nucleotide binding]; other site 498214011129 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 498214011130 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 498214011131 active site 498214011132 glutamate racemase; Provisional; Region: PRK00865 498214011133 glutamine synthetase, type I; Region: GlnA; TIGR00653 498214011134 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 498214011135 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 498214011136 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 498214011137 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 498214011138 hinge; other site 498214011139 active site 498214011140 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 498214011141 Sporulation and spore germination; Region: Germane; pfam10646 498214011142 hypothetical protein; Provisional; Region: PRK05590 498214011143 SEC-C motif; Region: SEC-C; pfam02810 498214011144 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 498214011145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 498214011146 Histidine kinase; Region: HisKA_3; pfam07730 498214011147 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 498214011148 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 498214011149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 498214011150 active site 498214011151 phosphorylation site [posttranslational modification] 498214011152 intermolecular recognition site; other site 498214011153 dimerization interface [polypeptide binding]; other site 498214011154 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 498214011155 DNA binding residues [nucleotide binding] 498214011156 dimerization interface [polypeptide binding]; other site 498214011157 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214011158 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 498214011159 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 498214011160 methionine aminopeptidase; Provisional; Region: PRK12318 498214011161 SEC-C motif; Region: SEC-C; pfam02810 498214011162 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 498214011163 active site 498214011164 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 498214011165 putative FMN binding site [chemical binding]; other site 498214011166 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 498214011167 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 498214011168 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 498214011169 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 498214011170 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 498214011171 hypothetical protein; Provisional; Region: PRK10977 498214011172 Pyruvate formate lyase; Region: PFL; pfam02901 498214011173 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 498214011174 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 498214011175 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 498214011176 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 498214011177 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 498214011178 FeS/SAM binding site; other site 498214011179 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 498214011180 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 498214011181 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 498214011182 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 498214011183 G1 box; other site 498214011184 GTP/Mg2+ binding site [chemical binding]; other site 498214011185 Switch I region; other site 498214011186 G2 box; other site 498214011187 Switch II region; other site 498214011188 G3 box; other site 498214011189 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 498214011190 Na binding site [ion binding]; other site 498214011191 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 498214011192 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 498214011193 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 498214011194 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 498214011195 active site 498214011196 PHP-associated; Region: PHP_C; pfam13263 498214011197 dUTPase; Region: dUTPase_2; pfam08761 498214011198 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 498214011199 active site 498214011200 homodimer interface [polypeptide binding]; other site 498214011201 metal binding site [ion binding]; metal-binding site 498214011202 Protein of unknown function, DUF606; Region: DUF606; pfam04657 498214011203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 498214011204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 498214011205 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 498214011206 dimerization interface [polypeptide binding]; other site 498214011207 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 498214011208 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 498214011209 active site 498214011210 catalytic residues [active] 498214011211 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 498214011212 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 498214011213 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 498214011214 putative dimerization interface [polypeptide binding]; other site 498214011215 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 498214011216 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 498214011217 putative ligand binding site [chemical binding]; other site 498214011218 NAD binding site [chemical binding]; other site 498214011219 catalytic site [active] 498214011220 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 498214011221 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 498214011222 Elongation factor 1 gamma, conserved domain; Region: EF1G; pfam00647 498214011223 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 498214011224 biotin carboxylase; Validated; Region: PRK05586 498214011225 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 498214011226 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 498214011227 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 498214011228 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 498214011229 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 498214011230 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 498214011231 carboxyltransferase (CT) interaction site; other site 498214011232 biotinylation site [posttranslational modification]; other site 498214011233 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 498214011234 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 498214011235 dimer interface [polypeptide binding]; other site 498214011236 active site 498214011237 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 498214011238 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 498214011239 NAD(P) binding site [chemical binding]; other site 498214011240 homotetramer interface [polypeptide binding]; other site 498214011241 homodimer interface [polypeptide binding]; other site 498214011242 active site 498214011243 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 498214011244 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 498214011245 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 498214011246 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 498214011247 FMN binding site [chemical binding]; other site 498214011248 substrate binding site [chemical binding]; other site 498214011249 putative catalytic residue [active] 498214011250 acyl carrier protein; Provisional; Region: acpP; PRK00982 498214011251 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 498214011252 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 498214011253 dimer interface [polypeptide binding]; other site 498214011254 active site 498214011255 CoA binding pocket [chemical binding]; other site 498214011256 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 498214011257 MarR family; Region: MarR_2; pfam12802 498214011258 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 498214011259 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 498214011260 FMN binding site [chemical binding]; other site 498214011261 substrate binding site [chemical binding]; other site 498214011262 putative catalytic residue [active] 498214011263 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 498214011264 Peptidase family M23; Region: Peptidase_M23; pfam01551 498214011265 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 498214011266 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 498214011267 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 498214011268 DNA replication protein DnaC; Validated; Region: PRK06835 498214011269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214011270 Walker A motif; other site 498214011271 ATP binding site [chemical binding]; other site 498214011272 PEP synthetase regulatory protein; Provisional; Region: PRK05339 498214011273 CoA binding domain; Region: CoA_binding_2; pfam13380 498214011274 flavoprotein, HI0933 family; Region: TIGR00275 498214011275 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 498214011276 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 498214011277 active site 498214011278 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 498214011279 active site 498214011280 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 498214011281 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 498214011282 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 498214011283 GDP-binding site [chemical binding]; other site 498214011284 ACT binding site; other site 498214011285 IMP binding site; other site 498214011286 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 498214011287 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 498214011288 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 498214011289 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 498214011290 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 498214011291 active site 498214011292 substrate binding site [chemical binding]; other site 498214011293 metal binding site [ion binding]; metal-binding site 498214011294 replicative DNA helicase; Provisional; Region: PRK05595 498214011295 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 498214011296 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 498214011297 Walker A motif; other site 498214011298 ATP binding site [chemical binding]; other site 498214011299 Walker B motif; other site 498214011300 DNA binding loops [nucleotide binding] 498214011301 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 498214011302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 498214011303 Walker A motif; other site 498214011304 ATP binding site [chemical binding]; other site 498214011305 Walker B motif; other site 498214011306 arginine finger; other site 498214011307 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 498214011308 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 498214011309 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 498214011310 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 498214011311 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 498214011312 DHH family; Region: DHH; pfam01368 498214011313 DHHA1 domain; Region: DHHA1; pfam02272 498214011314 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 498214011315 MazG-like family; Region: MazG-like; pfam12643 498214011316 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 498214011317 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 498214011318 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 498214011319 dimer interface [polypeptide binding]; other site 498214011320 ssDNA binding site [nucleotide binding]; other site 498214011321 tetramer (dimer of dimers) interface [polypeptide binding]; other site 498214011322 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 498214011323 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 498214011324 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 498214011325 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 498214011326 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 498214011327 Mechanosensitive ion channel; Region: MS_channel; pfam00924 498214011328 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 498214011329 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 498214011330 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 498214011331 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 498214011332 catalytic residue [active] 498214011333 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 498214011334 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 498214011335 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 498214011336 ParB-like nuclease domain; Region: ParB; smart00470 498214011337 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 498214011338 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 498214011339 P-loop; other site 498214011340 Magnesium ion binding site [ion binding]; other site 498214011341 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 498214011342 Magnesium ion binding site [ion binding]; other site 498214011343 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 498214011344 ParB-like nuclease domain; Region: ParBc; pfam02195 498214011345 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 498214011346 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 498214011347 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 498214011348 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 498214011349 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 498214011350 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 498214011351 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 498214011352 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 498214011353 trmE is a tRNA modification GTPase; Region: trmE; cd04164 498214011354 G1 box; other site 498214011355 GTP/Mg2+ binding site [chemical binding]; other site 498214011356 Switch I region; other site 498214011357 G2 box; other site 498214011358 Switch II region; other site 498214011359 G3 box; other site 498214011360 G4 box; other site 498214011361 G5 box; other site 498214011362 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 498214011363 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 498214011364 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 498214011365 G-X-X-G motif; other site 498214011366 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 498214011367 RxxxH motif; other site 498214011368 putative inner membrane protein translocase component YidC; Provisional; Region: PRK00145 498214011369 Haemolytic domain; Region: Haemolytic; pfam01809 498214011370 ribonuclease P; Reviewed; Region: rnpA; PRK00499 498214011371 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399