-- dump date 20140619_043018 -- class Genbank::misc_feature -- table misc_feature_note -- id note 441770000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 441770000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 441770000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770000004 Walker A motif; other site 441770000005 ATP binding site [chemical binding]; other site 441770000006 Walker B motif; other site 441770000007 arginine finger; other site 441770000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 441770000009 DnaA box-binding interface [nucleotide binding]; other site 441770000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 441770000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 441770000012 putative DNA binding surface [nucleotide binding]; other site 441770000013 dimer interface [polypeptide binding]; other site 441770000014 beta-clamp/clamp loader binding surface; other site 441770000015 beta-clamp/translesion DNA polymerase binding surface; other site 441770000016 S4 domain; Region: S4_2; pfam13275 441770000017 recombination protein F; Reviewed; Region: recF; PRK00064 441770000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 441770000019 Walker A/P-loop; other site 441770000020 ATP binding site [chemical binding]; other site 441770000021 Q-loop/lid; other site 441770000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770000023 ABC transporter signature motif; other site 441770000024 Walker B; other site 441770000025 D-loop; other site 441770000026 H-loop/switch region; other site 441770000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 441770000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770000029 Mg2+ binding site [ion binding]; other site 441770000030 G-X-G motif; other site 441770000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 441770000032 anchoring element; other site 441770000033 dimer interface [polypeptide binding]; other site 441770000034 ATP binding site [chemical binding]; other site 441770000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 441770000036 active site 441770000037 putative metal-binding site [ion binding]; other site 441770000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 441770000039 DNA gyrase subunit A; Validated; Region: PRK05560 441770000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 441770000041 CAP-like domain; other site 441770000042 active site 441770000043 primary dimer interface [polypeptide binding]; other site 441770000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441770000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441770000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441770000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441770000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441770000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441770000050 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 441770000051 HTH domain; Region: HTH_11; pfam08279 441770000052 3H domain; Region: 3H; pfam02829 441770000053 Uncharacterized conserved protein [Function unknown]; Region: COG2006 441770000054 Domain of unknown function (DUF362); Region: DUF362; pfam04015 441770000055 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 441770000056 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 441770000057 hypothetical protein; Validated; Region: PRK00068 441770000058 Uncharacterized conserved protein [Function unknown]; Region: COG1615 441770000059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 441770000060 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441770000061 Predicted dehydrogenase [General function prediction only]; Region: COG0579 441770000062 hydroxyglutarate oxidase; Provisional; Region: PRK11728 441770000063 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 441770000064 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 441770000065 seryl-tRNA synthetase; Provisional; Region: PRK05431 441770000066 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 441770000067 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 441770000068 dimer interface [polypeptide binding]; other site 441770000069 active site 441770000070 motif 1; other site 441770000071 motif 2; other site 441770000072 motif 3; other site 441770000073 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441770000074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770000075 Walker A/P-loop; other site 441770000076 ATP binding site [chemical binding]; other site 441770000077 Q-loop/lid; other site 441770000078 ABC transporter signature motif; other site 441770000079 Walker B; other site 441770000080 D-loop; other site 441770000081 H-loop/switch region; other site 441770000082 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 441770000083 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 441770000084 ABC1 family; Region: ABC1; cl17513 441770000085 Uncharacterized conserved protein [Function unknown]; Region: COG3937 441770000086 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 441770000087 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 441770000088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770000089 Walker A motif; other site 441770000090 ATP binding site [chemical binding]; other site 441770000091 Walker B motif; other site 441770000092 arginine finger; other site 441770000093 methionine gamma-lyase; Provisional; Region: PRK06234 441770000094 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 441770000095 homodimer interface [polypeptide binding]; other site 441770000096 substrate-cofactor binding pocket; other site 441770000097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770000098 catalytic residue [active] 441770000099 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 441770000100 nucleoside/Zn binding site; other site 441770000101 dimer interface [polypeptide binding]; other site 441770000102 catalytic motif [active] 441770000103 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 441770000104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770000105 Walker A motif; other site 441770000106 ATP binding site [chemical binding]; other site 441770000107 Walker B motif; other site 441770000108 arginine finger; other site 441770000109 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 441770000110 hypothetical protein; Validated; Region: PRK00153 441770000111 recombination protein RecR; Reviewed; Region: recR; PRK00076 441770000112 RecR protein; Region: RecR; pfam02132 441770000113 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 441770000114 putative active site [active] 441770000115 putative metal-binding site [ion binding]; other site 441770000116 tetramer interface [polypeptide binding]; other site 441770000117 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 441770000118 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 441770000119 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 441770000120 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 441770000121 putative NADH binding site [chemical binding]; other site 441770000122 putative active site [active] 441770000123 nudix motif; other site 441770000124 putative metal binding site [ion binding]; other site 441770000125 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 441770000126 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 441770000127 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 441770000128 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 441770000129 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 441770000130 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 441770000131 putative ATP binding site [chemical binding]; other site 441770000132 putative substrate interface [chemical binding]; other site 441770000133 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 441770000134 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 441770000135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 441770000136 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 441770000137 active site 441770000138 Fe-S cluster binding site [ion binding]; other site 441770000139 RNA polymerase factor sigma-70; Validated; Region: PRK06811 441770000140 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441770000141 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441770000142 DNA binding residues [nucleotide binding] 441770000143 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 441770000144 SurA N-terminal domain; Region: SurA_N_3; cl07813 441770000145 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 441770000146 NAD-dependent deacetylase; Provisional; Region: PRK00481 441770000147 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 441770000148 NAD+ binding site [chemical binding]; other site 441770000149 substrate binding site [chemical binding]; other site 441770000150 Zn binding site [ion binding]; other site 441770000151 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 441770000152 dimer interface [polypeptide binding]; other site 441770000153 catalytic triad [active] 441770000154 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 441770000155 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 441770000156 Cl binding site [ion binding]; other site 441770000157 oligomer interface [polypeptide binding]; other site 441770000158 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 441770000159 amidohydrolase; Region: amidohydrolases; TIGR01891 441770000160 metal binding site [ion binding]; metal-binding site 441770000161 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 441770000162 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 441770000163 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 441770000164 homodimer interface [polypeptide binding]; other site 441770000165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770000166 catalytic residue [active] 441770000167 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 441770000168 thymidylate kinase; Provisional; Region: PRK13975; cl17243 441770000169 Protein of unknown function (DUF970); Region: DUF970; pfam06153 441770000170 DNA polymerase III subunit delta'; Validated; Region: PRK05564 441770000171 DNA polymerase III subunit delta'; Validated; Region: PRK08485 441770000172 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 441770000173 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 441770000174 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 441770000175 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 441770000176 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 441770000177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770000178 S-adenosylmethionine binding site [chemical binding]; other site 441770000179 Predicted methyltransferases [General function prediction only]; Region: COG0313 441770000180 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 441770000181 putative SAM binding site [chemical binding]; other site 441770000182 putative homodimer interface [polypeptide binding]; other site 441770000183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 441770000184 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 441770000185 NlpC/P60 family; Region: NLPC_P60; pfam00877 441770000186 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 441770000187 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 441770000188 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 441770000189 arginine deiminase; Provisional; Region: PRK01388 441770000190 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 441770000191 homotrimer interaction site [polypeptide binding]; other site 441770000192 zinc binding site [ion binding]; other site 441770000193 CDP-binding sites; other site 441770000194 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 441770000195 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 441770000196 putative active site [active] 441770000197 putative metal binding site [ion binding]; other site 441770000198 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 441770000199 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 441770000200 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441770000201 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 441770000202 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 441770000203 Fe-S cluster binding site [ion binding]; other site 441770000204 active site 441770000205 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441770000206 MarR family; Region: MarR_2; cl17246 441770000207 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 441770000208 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 441770000209 active site 441770000210 HIGH motif; other site 441770000211 KMSKS motif; other site 441770000212 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 441770000213 anticodon binding site; other site 441770000214 tRNA binding surface [nucleotide binding]; other site 441770000215 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 441770000216 dimer interface [polypeptide binding]; other site 441770000217 putative tRNA-binding site [nucleotide binding]; other site 441770000218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 441770000219 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 441770000220 active site 441770000221 Domain of unknown function (DUF348); Region: DUF348; pfam03990 441770000222 Domain of unknown function (DUF348); Region: DUF348; pfam03990 441770000223 G5 domain; Region: G5; pfam07501 441770000224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 441770000225 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 441770000226 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 441770000227 putative active site [active] 441770000228 putative metal binding site [ion binding]; other site 441770000229 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 441770000230 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 441770000231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770000232 S-adenosylmethionine binding site [chemical binding]; other site 441770000233 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 441770000234 HlyD family secretion protein; Region: HlyD_3; pfam13437 441770000235 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441770000236 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441770000237 Walker A/P-loop; other site 441770000238 ATP binding site [chemical binding]; other site 441770000239 Q-loop/lid; other site 441770000240 ABC transporter signature motif; other site 441770000241 Walker B; other site 441770000242 D-loop; other site 441770000243 H-loop/switch region; other site 441770000244 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 441770000245 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 441770000246 FtsX-like permease family; Region: FtsX; pfam02687 441770000247 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 441770000248 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441770000249 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 441770000250 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 441770000251 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441770000252 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441770000253 metal binding site [ion binding]; metal-binding site 441770000254 active site 441770000255 I-site; other site 441770000256 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 441770000257 MgtC family; Region: MgtC; pfam02308 441770000258 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 441770000259 ATP cone domain; Region: ATP-cone; pfam03477 441770000260 Class III ribonucleotide reductase; Region: RNR_III; cd01675 441770000261 effector binding site; other site 441770000262 active site 441770000263 Zn binding site [ion binding]; other site 441770000264 glycine loop; other site 441770000265 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 441770000266 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 441770000267 MSEP-CTERM protein; Region: MSEP-CTERM; TIGR04286 441770000268 Predicted transcriptional regulators [Transcription]; Region: COG1695 441770000269 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 441770000270 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 441770000271 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 441770000272 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 441770000273 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 441770000274 HIGH motif; other site 441770000275 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 441770000276 active site 441770000277 KMSKS motif; other site 441770000278 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 441770000279 tRNA binding surface [nucleotide binding]; other site 441770000280 anticodon binding site; other site 441770000281 Transcriptional regulators [Transcription]; Region: PurR; COG1609 441770000282 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 441770000283 DNA binding site [nucleotide binding] 441770000284 domain linker motif; other site 441770000285 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 441770000286 AAA domain; Region: AAA_11; pfam13086 441770000287 Part of AAA domain; Region: AAA_19; pfam13245 441770000288 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 441770000289 AAA domain; Region: AAA_12; pfam13087 441770000290 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 441770000291 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 441770000292 Substrate binding site; other site 441770000293 Cupin domain; Region: Cupin_2; cl17218 441770000294 hypothetical protein; Provisional; Region: PRK04194 441770000295 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 441770000296 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 441770000297 Ligand Binding Site [chemical binding]; other site 441770000298 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 441770000299 AIR carboxylase; Region: AIRC; smart01001 441770000300 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 441770000301 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770000302 FeS/SAM binding site; other site 441770000303 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 441770000304 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 441770000305 glycosyltransferase, GG-Bacteroidales peptide system; Region: glyco_rSAM_CFB; TIGR04157 441770000306 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 441770000307 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 441770000308 substrate binding site [chemical binding]; other site 441770000309 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 441770000310 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 441770000311 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 441770000312 substrate binding site [chemical binding]; other site 441770000313 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441770000314 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 441770000315 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 441770000316 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 441770000317 active site 441770000318 ATP binding site [chemical binding]; other site 441770000319 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 441770000320 substrate binding site [chemical binding]; other site 441770000321 YabG peptidase U57; Region: Peptidase_U57; pfam05582 441770000322 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 441770000323 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 441770000324 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 441770000325 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 441770000326 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441770000327 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 441770000328 proposed catalytic triad [active] 441770000329 active site nucleophile [active] 441770000330 cyanophycin synthetase; Provisional; Region: PRK14016 441770000331 ATP-grasp domain; Region: ATP-grasp_4; cl17255 441770000332 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441770000333 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441770000334 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 441770000335 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 441770000336 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 441770000337 Spore germination protein; Region: Spore_permease; cl17796 441770000338 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 441770000339 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 441770000340 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 441770000341 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 441770000342 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 441770000343 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441770000344 germination protein YpeB; Region: spore_YpeB; TIGR02889 441770000345 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 441770000346 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 441770000347 Ligand Binding Site [chemical binding]; other site 441770000348 Domain of unknown function (DUF814); Region: DUF814; pfam05670 441770000349 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 441770000350 CTP synthetase; Validated; Region: pyrG; PRK05380 441770000351 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 441770000352 Catalytic site [active] 441770000353 active site 441770000354 UTP binding site [chemical binding]; other site 441770000355 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 441770000356 active site 441770000357 putative oxyanion hole; other site 441770000358 catalytic triad [active] 441770000359 transcription termination factor Rho; Provisional; Region: rho; PRK09376 441770000360 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 441770000361 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 441770000362 RNA binding site [nucleotide binding]; other site 441770000363 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 441770000364 Walker A motif; other site 441770000365 ATP binding site [chemical binding]; other site 441770000366 Walker B motif; other site 441770000367 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 441770000368 thymidine kinase; Provisional; Region: PRK04296 441770000369 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 441770000370 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 441770000371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770000372 peptide chain release factor 1; Validated; Region: prfA; PRK00591 441770000373 This domain is found in peptide chain release factors; Region: PCRF; smart00937 441770000374 RF-1 domain; Region: RF-1; pfam00472 441770000375 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 441770000376 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 441770000377 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 441770000378 Low molecular weight phosphatase family; Region: LMWPc; cd00115 441770000379 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 441770000380 active site 441770000381 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 441770000382 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441770000383 active site 441770000384 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 441770000385 active site 441770000386 Zn binding site [ion binding]; other site 441770000387 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 441770000388 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 441770000389 Mg++ binding site [ion binding]; other site 441770000390 putative catalytic motif [active] 441770000391 substrate binding site [chemical binding]; other site 441770000392 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 441770000393 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 441770000394 active site 441770000395 homodimer interface [polypeptide binding]; other site 441770000396 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 441770000397 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 441770000398 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 441770000399 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 441770000400 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 441770000401 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 441770000402 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 441770000403 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 441770000404 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 441770000405 beta subunit interaction interface [polypeptide binding]; other site 441770000406 Walker A motif; other site 441770000407 ATP binding site [chemical binding]; other site 441770000408 Walker B motif; other site 441770000409 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 441770000410 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 441770000411 core domain interface [polypeptide binding]; other site 441770000412 delta subunit interface [polypeptide binding]; other site 441770000413 epsilon subunit interface [polypeptide binding]; other site 441770000414 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 441770000415 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 441770000416 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 441770000417 alpha subunit interaction interface [polypeptide binding]; other site 441770000418 Walker A motif; other site 441770000419 ATP binding site [chemical binding]; other site 441770000420 Walker B motif; other site 441770000421 inhibitor binding site; inhibition site 441770000422 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 441770000423 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450 441770000424 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 441770000425 gamma subunit interface [polypeptide binding]; other site 441770000426 epsilon subunit interface [polypeptide binding]; other site 441770000427 LBP interface [polypeptide binding]; other site 441770000428 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 441770000429 stage II sporulation protein D; Region: spore_II_D; TIGR02870 441770000430 Stage II sporulation protein; Region: SpoIID; pfam08486 441770000431 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 441770000432 Peptidase family M23; Region: Peptidase_M23; pfam01551 441770000433 Stage III sporulation protein D; Region: SpoIIID; pfam12116 441770000434 rod shape-determining protein Mbl; Provisional; Region: PRK13928 441770000435 MreB and similar proteins; Region: MreB_like; cd10225 441770000436 nucleotide binding site [chemical binding]; other site 441770000437 Mg binding site [ion binding]; other site 441770000438 putative protofilament interaction site [polypeptide binding]; other site 441770000439 RodZ interaction site [polypeptide binding]; other site 441770000440 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 441770000441 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 441770000442 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 441770000443 Ligand Binding Site [chemical binding]; other site 441770000444 S-adenosylmethionine synthetase; Validated; Region: PRK05250 441770000445 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 441770000446 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 441770000447 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 441770000448 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 441770000449 AAA domain; Region: AAA_30; pfam13604 441770000450 Family description; Region: UvrD_C_2; pfam13538 441770000451 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 441770000452 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 441770000453 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441770000454 active site 441770000455 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 441770000456 30S subunit binding site; other site 441770000457 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 441770000458 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 441770000459 ATP binding site [chemical binding]; other site 441770000460 putative Mg++ binding site [ion binding]; other site 441770000461 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 441770000462 SEC-C motif; Region: SEC-C; pfam02810 441770000463 peptide chain release factor 2; Provisional; Region: PRK05589 441770000464 PCRF domain; Region: PCRF; pfam03462 441770000465 RF-1 domain; Region: RF-1; pfam00472 441770000466 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 441770000467 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 441770000468 Peptidase family M28; Region: Peptidase_M28; pfam04389 441770000469 metal binding site [ion binding]; metal-binding site 441770000470 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 441770000471 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 441770000472 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 441770000473 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 441770000474 RNA binding site [nucleotide binding]; other site 441770000475 Predicted membrane protein [Function unknown]; Region: COG3601 441770000476 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 441770000477 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 441770000478 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 441770000479 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 441770000480 putative active site [active] 441770000481 putative metal binding site [ion binding]; other site 441770000482 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441770000483 dimerization interface [polypeptide binding]; other site 441770000484 putative DNA binding site [nucleotide binding]; other site 441770000485 putative Zn2+ binding site [ion binding]; other site 441770000486 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 441770000487 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 441770000488 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441770000489 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 441770000490 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 441770000491 active site residue [active] 441770000492 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 441770000493 CPxP motif; other site 441770000494 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 441770000495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 441770000496 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 441770000497 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 441770000498 synthetase active site [active] 441770000499 NTP binding site [chemical binding]; other site 441770000500 metal binding site [ion binding]; metal-binding site 441770000501 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 441770000502 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 441770000503 HIGH motif; other site 441770000504 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 441770000505 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441770000506 active site 441770000507 KMSKS motif; other site 441770000508 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 441770000509 tRNA binding surface [nucleotide binding]; other site 441770000510 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 441770000511 active site residue [active] 441770000512 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 441770000513 HSP70 interaction site [polypeptide binding]; other site 441770000514 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 441770000515 putative active site [active] 441770000516 putative triphosphate binding site [ion binding]; other site 441770000517 dimer interface [polypeptide binding]; other site 441770000518 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 441770000519 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 441770000520 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 441770000521 intersubunit interface [polypeptide binding]; other site 441770000522 active site 441770000523 zinc binding site [ion binding]; other site 441770000524 Na+ binding site [ion binding]; other site 441770000525 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 441770000526 Predicted membrane protein [Function unknown]; Region: COG2323 441770000527 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 441770000528 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 441770000529 active site 441770000530 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 441770000531 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 441770000532 FOG: CBS domain [General function prediction only]; Region: COG0517 441770000533 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 441770000534 putative lipid kinase; Reviewed; Region: PRK13059 441770000535 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 441770000536 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 441770000537 hypothetical protein; Provisional; Region: PRK00955 441770000538 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 441770000539 PRC-barrel domain; Region: PRC; pfam05239 441770000540 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 441770000541 MgtE intracellular N domain; Region: MgtE_N; smart00924 441770000542 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 441770000543 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 441770000544 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441770000545 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 441770000546 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 441770000547 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 441770000548 dimer interface [polypeptide binding]; other site 441770000549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770000550 catalytic residue [active] 441770000551 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 441770000552 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 441770000553 trimer interface [polypeptide binding]; other site 441770000554 active site 441770000555 substrate binding site [chemical binding]; other site 441770000556 CoA binding site [chemical binding]; other site 441770000557 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 441770000558 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 441770000559 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 441770000560 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 441770000561 putative acyl-acceptor binding pocket; other site 441770000562 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 441770000563 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 441770000564 minor groove reading motif; other site 441770000565 helix-hairpin-helix signature motif; other site 441770000566 substrate binding pocket [chemical binding]; other site 441770000567 active site 441770000568 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 441770000569 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 441770000570 Malic enzyme, N-terminal domain; Region: malic; pfam00390 441770000571 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 441770000572 putative NAD(P) binding site [chemical binding]; other site 441770000573 competence damage-inducible protein A; Provisional; Region: PRK00549 441770000574 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 441770000575 putative MPT binding site; other site 441770000576 Competence-damaged protein; Region: CinA; pfam02464 441770000577 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 441770000578 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 441770000579 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 441770000580 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 441770000581 putative oligomer interface [polypeptide binding]; other site 441770000582 putative active site [active] 441770000583 metal binding site [ion binding]; metal-binding site 441770000584 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 441770000585 VanW like protein; Region: VanW; pfam04294 441770000586 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 441770000587 VanW like protein; Region: VanW; pfam04294 441770000588 G5 domain; Region: G5; pfam07501 441770000589 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 441770000590 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770000591 FeS/SAM binding site; other site 441770000592 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 441770000593 EDD domain protein, DegV family; Region: DegV; TIGR00762 441770000594 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 441770000595 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 441770000596 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 441770000597 ligand binding site [chemical binding]; other site 441770000598 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 441770000599 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 441770000600 Walker A/P-loop; other site 441770000601 ATP binding site [chemical binding]; other site 441770000602 Q-loop/lid; other site 441770000603 ABC transporter signature motif; other site 441770000604 Walker B; other site 441770000605 D-loop; other site 441770000606 H-loop/switch region; other site 441770000607 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 441770000608 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 441770000609 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 441770000610 TM-ABC transporter signature motif; other site 441770000611 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 441770000612 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 441770000613 TM-ABC transporter signature motif; other site 441770000614 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 441770000615 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 441770000616 NodB motif; other site 441770000617 active site 441770000618 catalytic site [active] 441770000619 Zn binding site [ion binding]; other site 441770000620 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 441770000621 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 441770000622 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 441770000623 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 441770000624 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 441770000625 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 441770000626 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 441770000627 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 441770000628 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 441770000629 Phosphoglycerate kinase; Region: PGK; pfam00162 441770000630 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 441770000631 substrate binding site [chemical binding]; other site 441770000632 hinge regions; other site 441770000633 ADP binding site [chemical binding]; other site 441770000634 catalytic site [active] 441770000635 triosephosphate isomerase; Provisional; Region: PRK14567 441770000636 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 441770000637 substrate binding site [chemical binding]; other site 441770000638 dimer interface [polypeptide binding]; other site 441770000639 catalytic triad [active] 441770000640 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 441770000641 phosphoglyceromutase; Provisional; Region: PRK05434 441770000642 enolase; Provisional; Region: eno; PRK00077 441770000643 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 441770000644 dimer interface [polypeptide binding]; other site 441770000645 metal binding site [ion binding]; metal-binding site 441770000646 substrate binding pocket [chemical binding]; other site 441770000647 Preprotein translocase SecG subunit; Region: SecG; pfam03840 441770000648 ribonuclease R; Region: RNase_R; TIGR02063 441770000649 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 441770000650 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 441770000651 RNB domain; Region: RNB; pfam00773 441770000652 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 441770000653 RNA binding site [nucleotide binding]; other site 441770000654 stationary phase survival protein SurE; Provisional; Region: PRK13933 441770000655 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 441770000656 SmpB-tmRNA interface; other site 441770000657 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 441770000658 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 441770000659 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 441770000660 FAD binding domain; Region: FAD_binding_4; pfam01565 441770000661 Berberine and berberine like; Region: BBE; pfam08031 441770000662 Part of AAA domain; Region: AAA_19; pfam13245 441770000663 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 441770000664 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441770000665 catalytic residue [active] 441770000666 flagellin; Provisional; Region: PRK12804 441770000667 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 441770000668 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 441770000669 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 441770000670 active site 441770000671 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 441770000672 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 441770000673 Malic enzyme, N-terminal domain; Region: malic; pfam00390 441770000674 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 441770000675 putative NAD(P) binding site [chemical binding]; other site 441770000676 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 441770000677 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 441770000678 PAS domain; Region: PAS; smart00091 441770000679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770000680 ATP binding site [chemical binding]; other site 441770000681 Mg2+ binding site [ion binding]; other site 441770000682 G-X-G motif; other site 441770000683 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 441770000684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770000685 active site 441770000686 phosphorylation site [posttranslational modification] 441770000687 intermolecular recognition site; other site 441770000688 dimerization interface [polypeptide binding]; other site 441770000689 HTH domain; Region: HTH_11; cl17392 441770000690 lysine transporter; Provisional; Region: PRK10836 441770000691 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441770000692 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 441770000693 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 441770000694 active site 441770000695 catalytic motif [active] 441770000696 Zn binding site [ion binding]; other site 441770000697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770000698 Coenzyme A binding pocket [chemical binding]; other site 441770000699 RibD C-terminal domain; Region: RibD_C; cl17279 441770000700 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 441770000701 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 441770000702 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 441770000703 active site 441770000704 catalytic site [active] 441770000705 substrate binding site [chemical binding]; other site 441770000706 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 441770000707 Dimer interface [polypeptide binding]; other site 441770000708 Isochorismatase family; Region: Isochorismatase; pfam00857 441770000709 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 441770000710 catalytic triad [active] 441770000711 conserved cis-peptide bond; other site 441770000712 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 441770000713 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441770000714 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441770000715 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 441770000716 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 441770000717 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 441770000718 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441770000719 catalytic loop [active] 441770000720 iron binding site [ion binding]; other site 441770000721 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 441770000722 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 441770000723 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 441770000724 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 441770000725 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 441770000726 catalytic residues [active] 441770000727 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 441770000728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770000729 active site 441770000730 phosphorylation site [posttranslational modification] 441770000731 intermolecular recognition site; other site 441770000732 dimerization interface [polypeptide binding]; other site 441770000733 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770000734 DNA binding site [nucleotide binding] 441770000735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770000736 HAMP domain; Region: HAMP; pfam00672 441770000737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770000738 dimer interface [polypeptide binding]; other site 441770000739 phosphorylation site [posttranslational modification] 441770000740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770000741 ATP binding site [chemical binding]; other site 441770000742 Mg2+ binding site [ion binding]; other site 441770000743 G-X-G motif; other site 441770000744 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 441770000745 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 441770000746 NAD binding site [chemical binding]; other site 441770000747 sugar binding site [chemical binding]; other site 441770000748 divalent metal binding site [ion binding]; other site 441770000749 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 441770000750 dimer interface [polypeptide binding]; other site 441770000751 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 441770000752 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441770000753 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441770000754 active site turn [active] 441770000755 phosphorylation site [posttranslational modification] 441770000756 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 441770000757 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 441770000758 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 441770000759 putative active site [active] 441770000760 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 441770000761 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 441770000762 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 441770000763 putative active site [active] 441770000764 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 441770000765 HPr interaction site; other site 441770000766 glycerol kinase (GK) interaction site [polypeptide binding]; other site 441770000767 active site 441770000768 phosphorylation site [posttranslational modification] 441770000769 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770000770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770000771 active site 441770000772 phosphorylation site [posttranslational modification] 441770000773 intermolecular recognition site; other site 441770000774 dimerization interface [polypeptide binding]; other site 441770000775 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770000776 DNA binding site [nucleotide binding] 441770000777 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770000778 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 441770000779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770000780 ATP binding site [chemical binding]; other site 441770000781 Mg2+ binding site [ion binding]; other site 441770000782 G-X-G motif; other site 441770000783 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441770000784 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441770000785 Walker A/P-loop; other site 441770000786 ATP binding site [chemical binding]; other site 441770000787 Q-loop/lid; other site 441770000788 ABC transporter signature motif; other site 441770000789 Walker B; other site 441770000790 D-loop; other site 441770000791 H-loop/switch region; other site 441770000792 alanine racemase; Reviewed; Region: alr; PRK00053 441770000793 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 441770000794 active site 441770000795 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441770000796 dimer interface [polypeptide binding]; other site 441770000797 substrate binding site [chemical binding]; other site 441770000798 catalytic residues [active] 441770000799 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 441770000800 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441770000801 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441770000802 active site turn [active] 441770000803 phosphorylation site [posttranslational modification] 441770000804 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 441770000805 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 441770000806 NAD binding site [chemical binding]; other site 441770000807 sugar binding site [chemical binding]; other site 441770000808 divalent metal binding site [ion binding]; other site 441770000809 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 441770000810 dimer interface [polypeptide binding]; other site 441770000811 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 441770000812 HPr interaction site; other site 441770000813 glycerol kinase (GK) interaction site [polypeptide binding]; other site 441770000814 active site 441770000815 phosphorylation site [posttranslational modification] 441770000816 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 441770000817 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 441770000818 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 441770000819 putative active site [active] 441770000820 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 441770000821 DNA-binding site [nucleotide binding]; DNA binding site 441770000822 RNA-binding motif; other site 441770000823 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 441770000824 Predicted transcriptional regulator [Transcription]; Region: COG1959 441770000825 Transcriptional regulator; Region: Rrf2; pfam02082 441770000826 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 441770000827 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 441770000828 catalytic residues [active] 441770000829 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 441770000830 NADH(P)-binding; Region: NAD_binding_10; pfam13460 441770000831 NAD binding site [chemical binding]; other site 441770000832 substrate binding site [chemical binding]; other site 441770000833 putative active site [active] 441770000834 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 441770000835 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 441770000836 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 441770000837 putative active site [active] 441770000838 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 441770000839 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441770000840 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441770000841 active site turn [active] 441770000842 phosphorylation site [posttranslational modification] 441770000843 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 441770000844 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 441770000845 NAD binding site [chemical binding]; other site 441770000846 sugar binding site [chemical binding]; other site 441770000847 divalent metal binding site [ion binding]; other site 441770000848 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 441770000849 dimer interface [polypeptide binding]; other site 441770000850 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 441770000851 HPr interaction site; other site 441770000852 glycerol kinase (GK) interaction site [polypeptide binding]; other site 441770000853 active site 441770000854 phosphorylation site [posttranslational modification] 441770000855 Dehydratase family; Region: ILVD_EDD; pfam00920 441770000856 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 441770000857 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 441770000858 active site 441770000859 intersubunit interface [polypeptide binding]; other site 441770000860 catalytic residue [active] 441770000861 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 441770000862 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 441770000863 substrate binding site [chemical binding]; other site 441770000864 ATP binding site [chemical binding]; other site 441770000865 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 441770000866 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 441770000867 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 441770000868 active site 441770000869 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 441770000870 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770000871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770000872 active site 441770000873 phosphorylation site [posttranslational modification] 441770000874 intermolecular recognition site; other site 441770000875 dimerization interface [polypeptide binding]; other site 441770000876 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770000877 DNA binding site [nucleotide binding] 441770000878 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770000879 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441770000880 dimerization interface [polypeptide binding]; other site 441770000881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770000882 dimer interface [polypeptide binding]; other site 441770000883 phosphorylation site [posttranslational modification] 441770000884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770000885 ATP binding site [chemical binding]; other site 441770000886 Mg2+ binding site [ion binding]; other site 441770000887 G-X-G motif; other site 441770000888 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 441770000889 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 441770000890 Ligand binding site; other site 441770000891 Putative Catalytic site; other site 441770000892 DXD motif; other site 441770000893 Predicted membrane protein [Function unknown]; Region: COG2246 441770000894 GtrA-like protein; Region: GtrA; pfam04138 441770000895 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 441770000896 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 441770000897 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 441770000898 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441770000899 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770000900 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 441770000901 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 441770000902 intersubunit interface [polypeptide binding]; other site 441770000903 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 441770000904 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441770000905 ABC-ATPase subunit interface; other site 441770000906 dimer interface [polypeptide binding]; other site 441770000907 putative PBP binding regions; other site 441770000908 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 441770000909 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 441770000910 Walker A/P-loop; other site 441770000911 ATP binding site [chemical binding]; other site 441770000912 Q-loop/lid; other site 441770000913 ABC transporter signature motif; other site 441770000914 Walker B; other site 441770000915 D-loop; other site 441770000916 H-loop/switch region; other site 441770000917 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441770000918 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 441770000919 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 441770000920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770000921 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 441770000922 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 441770000923 intersubunit interface [polypeptide binding]; other site 441770000924 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 441770000925 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 441770000926 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 441770000927 intersubunit interface [polypeptide binding]; other site 441770000928 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 441770000929 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441770000930 ABC-ATPase subunit interface; other site 441770000931 dimer interface [polypeptide binding]; other site 441770000932 putative PBP binding regions; other site 441770000933 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 441770000934 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441770000935 ABC-ATPase subunit interface; other site 441770000936 dimer interface [polypeptide binding]; other site 441770000937 putative PBP binding regions; other site 441770000938 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 441770000939 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 441770000940 Walker A/P-loop; other site 441770000941 ATP binding site [chemical binding]; other site 441770000942 Q-loop/lid; other site 441770000943 ABC transporter signature motif; other site 441770000944 Walker B; other site 441770000945 D-loop; other site 441770000946 H-loop/switch region; other site 441770000947 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441770000948 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441770000949 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 441770000950 Walker A/P-loop; other site 441770000951 ATP binding site [chemical binding]; other site 441770000952 Q-loop/lid; other site 441770000953 ABC transporter signature motif; other site 441770000954 Walker B; other site 441770000955 D-loop; other site 441770000956 H-loop/switch region; other site 441770000957 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 441770000958 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 441770000959 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 441770000960 xanthine permease; Region: pbuX; TIGR03173 441770000961 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441770000962 active site 441770000963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770000964 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770000965 active site 441770000966 phosphorylation site [posttranslational modification] 441770000967 intermolecular recognition site; other site 441770000968 dimerization interface [polypeptide binding]; other site 441770000969 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770000970 DNA binding site [nucleotide binding] 441770000971 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770000972 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 441770000973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770000974 ATP binding site [chemical binding]; other site 441770000975 Mg2+ binding site [ion binding]; other site 441770000976 G-X-G motif; other site 441770000977 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 441770000978 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441770000979 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441770000980 Walker A/P-loop; other site 441770000981 ATP binding site [chemical binding]; other site 441770000982 Q-loop/lid; other site 441770000983 ABC transporter signature motif; other site 441770000984 Walker B; other site 441770000985 D-loop; other site 441770000986 H-loop/switch region; other site 441770000987 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 441770000988 FtsX-like permease family; Region: FtsX; pfam02687 441770000989 LrgA family; Region: LrgA; pfam03788 441770000990 LrgB-like family; Region: LrgB; pfam04172 441770000991 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770000992 Radical SAM superfamily; Region: Radical_SAM; pfam04055 441770000993 FeS/SAM binding site; other site 441770000994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 441770000995 hypothetical protein; Provisional; Region: PRK13663 441770000996 Accessory gene regulator B; Region: AgrB; pfam04647 441770000997 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 441770000998 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 441770000999 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441770001000 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441770001001 metal binding site [ion binding]; metal-binding site 441770001002 active site 441770001003 I-site; other site 441770001004 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 441770001005 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441770001006 Zn2+ binding site [ion binding]; other site 441770001007 Mg2+ binding site [ion binding]; other site 441770001008 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 441770001009 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 441770001010 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 441770001011 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 441770001012 PAS domain; Region: PAS; smart00091 441770001013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770001014 dimer interface [polypeptide binding]; other site 441770001015 phosphorylation site [posttranslational modification] 441770001016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770001017 ATP binding site [chemical binding]; other site 441770001018 Mg2+ binding site [ion binding]; other site 441770001019 G-X-G motif; other site 441770001020 Accessory gene regulator B; Region: AgrB; pfam04647 441770001021 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 441770001022 PAS domain S-box; Region: sensory_box; TIGR00229 441770001023 PAS domain; Region: PAS_8; pfam13188 441770001024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770001025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770001026 dimer interface [polypeptide binding]; other site 441770001027 phosphorylation site [posttranslational modification] 441770001028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770001029 ATP binding site [chemical binding]; other site 441770001030 Mg2+ binding site [ion binding]; other site 441770001031 G-X-G motif; other site 441770001032 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 441770001033 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 441770001034 Ligand Binding Site [chemical binding]; other site 441770001035 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770001036 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 441770001037 non-specific DNA binding site [nucleotide binding]; other site 441770001038 salt bridge; other site 441770001039 sequence-specific DNA binding site [nucleotide binding]; other site 441770001040 Cupin domain; Region: Cupin_2; pfam07883 441770001041 Amino acid permease; Region: AA_permease_2; pfam13520 441770001042 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 441770001043 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 441770001044 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 441770001045 active site 441770001046 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 441770001047 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 441770001048 putative catalytic cysteine [active] 441770001049 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 441770001050 putative active site [active] 441770001051 metal binding site [ion binding]; metal-binding site 441770001052 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 441770001053 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 441770001054 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 441770001055 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 441770001056 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 441770001057 active site 441770001058 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 441770001059 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 441770001060 NodB motif; other site 441770001061 active site 441770001062 catalytic site [active] 441770001063 Zn binding site [ion binding]; other site 441770001064 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770001065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770001066 active site 441770001067 phosphorylation site [posttranslational modification] 441770001068 intermolecular recognition site; other site 441770001069 dimerization interface [polypeptide binding]; other site 441770001070 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770001071 DNA binding site [nucleotide binding] 441770001072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770001073 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441770001074 dimerization interface [polypeptide binding]; other site 441770001075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770001076 dimer interface [polypeptide binding]; other site 441770001077 phosphorylation site [posttranslational modification] 441770001078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770001079 ATP binding site [chemical binding]; other site 441770001080 Mg2+ binding site [ion binding]; other site 441770001081 G-X-G motif; other site 441770001082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441770001083 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 441770001084 Uncharacterized conserved protein [Function unknown]; Region: COG0398 441770001085 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 441770001086 CHASE4 domain; Region: CHASE4; pfam05228 441770001087 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441770001088 dimerization interface [polypeptide binding]; other site 441770001089 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441770001090 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441770001091 metal binding site [ion binding]; metal-binding site 441770001092 active site 441770001093 I-site; other site 441770001094 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 441770001095 Putative amidase domain; Region: Amidase_6; pfam12671 441770001096 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441770001097 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 441770001098 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 441770001099 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 441770001100 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 441770001101 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 441770001102 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 441770001103 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441770001104 catalytic residue [active] 441770001105 Predicted membrane protein [Function unknown]; Region: COG2855 441770001106 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 441770001107 active site 441770001108 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770001109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770001110 active site 441770001111 phosphorylation site [posttranslational modification] 441770001112 intermolecular recognition site; other site 441770001113 dimerization interface [polypeptide binding]; other site 441770001114 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770001115 DNA binding site [nucleotide binding] 441770001116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770001117 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441770001118 dimerization interface [polypeptide binding]; other site 441770001119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770001120 dimer interface [polypeptide binding]; other site 441770001121 phosphorylation site [posttranslational modification] 441770001122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770001123 ATP binding site [chemical binding]; other site 441770001124 Mg2+ binding site [ion binding]; other site 441770001125 G-X-G motif; other site 441770001126 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 441770001127 Na binding site [ion binding]; other site 441770001128 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 441770001129 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 441770001130 SLBB domain; Region: SLBB; pfam10531 441770001131 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 441770001132 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 441770001133 FMN-binding domain; Region: FMN_bind; cl01081 441770001134 electron transport complex RsxE subunit; Provisional; Region: PRK12405 441770001135 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 441770001136 ferredoxin; Validated; Region: PRK07118 441770001137 CheD chemotactic sensory transduction; Region: CheD; cl00810 441770001138 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 441770001139 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441770001140 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441770001141 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441770001142 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 441770001143 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 441770001144 trimer interface [polypeptide binding]; other site 441770001145 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 441770001146 ApbE family; Region: ApbE; pfam02424 441770001147 Cache domain; Region: Cache_1; pfam02743 441770001148 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441770001149 dimerization interface [polypeptide binding]; other site 441770001150 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441770001151 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770001152 dimer interface [polypeptide binding]; other site 441770001153 putative CheW interface [polypeptide binding]; other site 441770001154 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 441770001155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770001156 Walker A motif; other site 441770001157 ATP binding site [chemical binding]; other site 441770001158 Walker B motif; other site 441770001159 arginine finger; other site 441770001160 Peptidase family M41; Region: Peptidase_M41; pfam01434 441770001161 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 441770001162 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 441770001163 RNA/DNA hybrid binding site [nucleotide binding]; other site 441770001164 active site 441770001165 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441770001166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770001167 non-specific DNA binding site [nucleotide binding]; other site 441770001168 salt bridge; other site 441770001169 sequence-specific DNA binding site [nucleotide binding]; other site 441770001170 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441770001171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441770001172 binding surface 441770001173 TPR motif; other site 441770001174 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441770001175 Helix-turn-helix domain; Region: HTH_19; pfam12844 441770001176 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441770001177 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 441770001178 DJ-1 family protein; Region: not_thiJ; TIGR01383 441770001179 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 441770001180 conserved cys residue [active] 441770001181 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 441770001182 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 441770001183 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 441770001184 Clp amino terminal domain; Region: Clp_N; pfam02861 441770001185 Clp amino terminal domain; Region: Clp_N; pfam02861 441770001186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770001187 Walker A motif; other site 441770001188 ATP binding site [chemical binding]; other site 441770001189 Walker B motif; other site 441770001190 arginine finger; other site 441770001191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770001192 Walker A motif; other site 441770001193 ATP binding site [chemical binding]; other site 441770001194 Walker B motif; other site 441770001195 arginine finger; other site 441770001196 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 441770001197 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 441770001198 catalytic triad [active] 441770001199 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 441770001200 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441770001201 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 441770001202 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 441770001203 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 441770001204 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 441770001205 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 441770001206 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 441770001207 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 441770001208 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 441770001209 putative acyl-acceptor binding pocket; other site 441770001210 isopropylmalate/citramalate/homocitrate synthases; Region: LEU1_arch; TIGR02090 441770001211 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 441770001212 active site 441770001213 catalytic residues [active] 441770001214 metal binding site [ion binding]; metal-binding site 441770001215 aconitate hydratase; Validated; Region: PRK07229 441770001216 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 441770001217 substrate binding site [chemical binding]; other site 441770001218 ligand binding site [chemical binding]; other site 441770001219 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 441770001220 substrate binding site [chemical binding]; other site 441770001221 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 441770001222 tartrate dehydrogenase; Region: TTC; TIGR02089 441770001223 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 441770001224 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 441770001225 Walker A/P-loop; other site 441770001226 ATP binding site [chemical binding]; other site 441770001227 Q-loop/lid; other site 441770001228 ABC transporter signature motif; other site 441770001229 Walker B; other site 441770001230 D-loop; other site 441770001231 H-loop/switch region; other site 441770001232 Permease; Region: Permease; cl00510 441770001233 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 441770001234 Uncharacterized conserved protein [Function unknown]; Region: COG2155 441770001235 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 441770001236 tetramerization interface [polypeptide binding]; other site 441770001237 active site 441770001238 Pantoate-beta-alanine ligase; Region: PanC; cd00560 441770001239 pantoate--beta-alanine ligase; Region: panC; TIGR00018 441770001240 active site 441770001241 ATP-binding site [chemical binding]; other site 441770001242 pantoate-binding site; other site 441770001243 HXXH motif; other site 441770001244 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 441770001245 oligomerization interface [polypeptide binding]; other site 441770001246 active site 441770001247 metal binding site [ion binding]; metal-binding site 441770001248 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 441770001249 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 441770001250 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 441770001251 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 441770001252 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 441770001253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770001254 Walker A/P-loop; other site 441770001255 ATP binding site [chemical binding]; other site 441770001256 Q-loop/lid; other site 441770001257 ABC transporter signature motif; other site 441770001258 Walker B; other site 441770001259 D-loop; other site 441770001260 H-loop/switch region; other site 441770001261 Predicted transcriptional regulators [Transcription]; Region: COG1695 441770001262 Transcriptional regulator PadR-like family; Region: PadR; cl17335 441770001263 radical SAM peptide maturase, CXXX-repeat target family; Region: rSAM_Cxxx_rpt; TIGR04115 441770001264 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770001265 FeS/SAM binding site; other site 441770001266 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 441770001267 CXXX repeat peptide maturase; Region: CXXX_matur; TIGR04119 441770001268 CXXX repeat peptide modification system protein; Region: CXXX_rpt_assoc; TIGR04116 441770001269 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441770001270 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441770001271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770001272 Walker A/P-loop; other site 441770001273 ATP binding site [chemical binding]; other site 441770001274 Q-loop/lid; other site 441770001275 ABC transporter signature motif; other site 441770001276 Walker B; other site 441770001277 D-loop; other site 441770001278 H-loop/switch region; other site 441770001279 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 441770001280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441770001281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441770001282 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441770001283 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 441770001284 4Fe-4S binding domain; Region: Fer4; pfam00037 441770001285 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 441770001286 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 441770001287 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 441770001288 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 441770001289 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 441770001290 Family description; Region: UvrD_C_2; pfam13538 441770001291 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 441770001292 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 441770001293 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 441770001294 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770001295 dimer interface [polypeptide binding]; other site 441770001296 putative CheW interface [polypeptide binding]; other site 441770001297 peptidase T; Region: peptidase-T; TIGR01882 441770001298 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 441770001299 metal binding site [ion binding]; metal-binding site 441770001300 dimer interface [polypeptide binding]; other site 441770001301 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 441770001302 active site 441770001303 nucleophile elbow; other site 441770001304 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441770001305 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 441770001306 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 441770001307 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441770001308 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441770001309 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441770001310 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 441770001311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770001312 dimer interface [polypeptide binding]; other site 441770001313 conserved gate region; other site 441770001314 putative PBP binding loops; other site 441770001315 ABC-ATPase subunit interface; other site 441770001316 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 441770001317 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441770001318 substrate binding pocket [chemical binding]; other site 441770001319 membrane-bound complex binding site; other site 441770001320 hinge residues; other site 441770001321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770001322 S-adenosylmethionine binding site [chemical binding]; other site 441770001323 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 441770001324 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 441770001325 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 441770001326 thiamine phosphate binding site [chemical binding]; other site 441770001327 active site 441770001328 pyrophosphate binding site [ion binding]; other site 441770001329 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 441770001330 substrate binding site [chemical binding]; other site 441770001331 multimerization interface [polypeptide binding]; other site 441770001332 ATP binding site [chemical binding]; other site 441770001333 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 441770001334 dimer interface [polypeptide binding]; other site 441770001335 substrate binding site [chemical binding]; other site 441770001336 ATP binding site [chemical binding]; other site 441770001337 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 441770001338 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 441770001339 ATP-grasp domain; Region: ATP-grasp_4; cl17255 441770001340 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 441770001341 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 441770001342 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 441770001343 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 441770001344 TM-ABC transporter signature motif; other site 441770001345 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 441770001346 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 441770001347 TM-ABC transporter signature motif; other site 441770001348 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 441770001349 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 441770001350 Walker A/P-loop; other site 441770001351 ATP binding site [chemical binding]; other site 441770001352 Q-loop/lid; other site 441770001353 ABC transporter signature motif; other site 441770001354 Walker B; other site 441770001355 D-loop; other site 441770001356 H-loop/switch region; other site 441770001357 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 441770001358 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 441770001359 Walker A/P-loop; other site 441770001360 ATP binding site [chemical binding]; other site 441770001361 Q-loop/lid; other site 441770001362 ABC transporter signature motif; other site 441770001363 Walker B; other site 441770001364 D-loop; other site 441770001365 H-loop/switch region; other site 441770001366 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 441770001367 Uncharacterized conserved protein [Function unknown]; Region: COG2966 441770001368 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 441770001369 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 441770001370 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 441770001371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770001372 DNA-binding site [nucleotide binding]; DNA binding site 441770001373 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770001374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770001375 homodimer interface [polypeptide binding]; other site 441770001376 catalytic residue [active] 441770001377 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 441770001378 Repair protein; Region: Repair_PSII; pfam04536 441770001379 Repair protein; Region: Repair_PSII; pfam04536 441770001380 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 441770001381 nudix motif; other site 441770001382 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 441770001383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770001384 S-adenosylmethionine binding site [chemical binding]; other site 441770001385 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770001386 salt bridge; other site 441770001387 non-specific DNA binding site [nucleotide binding]; other site 441770001388 sequence-specific DNA binding site [nucleotide binding]; other site 441770001389 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 441770001390 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 441770001391 active site 441770001392 metal binding site [ion binding]; metal-binding site 441770001393 DNA binding site [nucleotide binding] 441770001394 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 441770001395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770001396 AAA domain; Region: AAA_23; pfam13476 441770001397 Walker A/P-loop; other site 441770001398 ATP binding site [chemical binding]; other site 441770001399 Q-loop/lid; other site 441770001400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770001401 ABC transporter signature motif; other site 441770001402 Walker B; other site 441770001403 D-loop; other site 441770001404 H-loop/switch region; other site 441770001405 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 441770001406 ADP-ribose binding site [chemical binding]; other site 441770001407 dimer interface [polypeptide binding]; other site 441770001408 active site 441770001409 nudix motif; other site 441770001410 metal binding site [ion binding]; metal-binding site 441770001411 Uncharacterized conserved protein [Function unknown]; Region: COG1284 441770001412 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 441770001413 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 441770001414 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 441770001415 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441770001416 dimerization interface [polypeptide binding]; other site 441770001417 putative DNA binding site [nucleotide binding]; other site 441770001418 putative Zn2+ binding site [ion binding]; other site 441770001419 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 441770001420 Heavy-metal-associated domain; Region: HMA; pfam00403 441770001421 metal-binding site [ion binding] 441770001422 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441770001423 Soluble P-type ATPase [General function prediction only]; Region: COG4087 441770001424 RecT family; Region: RecT; cl04285 441770001425 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 441770001426 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 441770001427 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 441770001428 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 441770001429 putative active site [active] 441770001430 PhoH-like protein; Region: PhoH; pfam02562 441770001431 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 441770001432 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 441770001433 putative FMN binding site [chemical binding]; other site 441770001434 NADPH bind site [chemical binding]; other site 441770001435 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 441770001436 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 441770001437 YcaO-like family; Region: YcaO; pfam02624 441770001438 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 441770001439 CAAX protease self-immunity; Region: Abi; pfam02517 441770001440 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441770001441 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770001442 Walker A/P-loop; other site 441770001443 ATP binding site [chemical binding]; other site 441770001444 Q-loop/lid; other site 441770001445 ABC transporter signature motif; other site 441770001446 Walker B; other site 441770001447 D-loop; other site 441770001448 H-loop/switch region; other site 441770001449 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 441770001450 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 441770001451 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 441770001452 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 441770001453 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 441770001454 ABC-2 type transporter; Region: ABC2_membrane; cl17235 441770001455 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 441770001456 Peptidase family M50; Region: Peptidase_M50; pfam02163 441770001457 active site 441770001458 putative substrate binding region [chemical binding]; other site 441770001459 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 441770001460 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 441770001461 transmembrane helices; other site 441770001462 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 441770001463 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 441770001464 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 441770001465 dimer interface [polypeptide binding]; other site 441770001466 catalytic triad [active] 441770001467 peroxidatic and resolving cysteines [active] 441770001468 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 441770001469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441770001470 NAD(P) binding site [chemical binding]; other site 441770001471 active site 441770001472 Response regulator receiver domain; Region: Response_reg; pfam00072 441770001473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770001474 active site 441770001475 phosphorylation site [posttranslational modification] 441770001476 intermolecular recognition site; other site 441770001477 dimerization interface [polypeptide binding]; other site 441770001478 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 441770001479 CHAP domain; Region: CHAP; pfam05257 441770001480 Bacterial SH3 domain; Region: SH3_3; pfam08239 441770001481 Bacterial SH3 domain; Region: SH3_3; pfam08239 441770001482 Bacterial SH3 domain; Region: SH3_3; pfam08239 441770001483 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 441770001484 Bacterial SH3 domain; Region: SH3_3; pfam08239 441770001485 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 441770001486 NlpC/P60 family; Region: NLPC_P60; pfam00877 441770001487 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 441770001488 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 441770001489 PAS fold; Region: PAS_4; pfam08448 441770001490 Response regulator receiver domain; Region: Response_reg; pfam00072 441770001491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770001492 active site 441770001493 phosphorylation site [posttranslational modification] 441770001494 intermolecular recognition site; other site 441770001495 dimerization interface [polypeptide binding]; other site 441770001496 Hpt domain; Region: Hpt; pfam01627 441770001497 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441770001498 Zn2+ binding site [ion binding]; other site 441770001499 Mg2+ binding site [ion binding]; other site 441770001500 Cache domain; Region: Cache_1; pfam02743 441770001501 HAMP domain; Region: HAMP; pfam00672 441770001502 dimerization interface [polypeptide binding]; other site 441770001503 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441770001504 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770001505 dimer interface [polypeptide binding]; other site 441770001506 putative CheW interface [polypeptide binding]; other site 441770001507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770001508 active site 441770001509 phosphorylation site [posttranslational modification] 441770001510 intermolecular recognition site; other site 441770001511 dimerization interface [polypeptide binding]; other site 441770001512 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 441770001513 seryl-tRNA synthetase; Provisional; Region: PRK05431 441770001514 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 441770001515 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 441770001516 motif 1; other site 441770001517 dimer interface [polypeptide binding]; other site 441770001518 active site 441770001519 motif 2; other site 441770001520 motif 3; other site 441770001521 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 441770001522 DEAD_2; Region: DEAD_2; pfam06733 441770001523 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 441770001524 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 441770001525 Predicted transcriptional regulators [Transcription]; Region: COG1725 441770001526 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770001527 DNA-binding site [nucleotide binding]; DNA binding site 441770001528 TrkA-C domain; Region: TrkA_C; pfam02080 441770001529 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 441770001530 putative active site [active] 441770001531 putative ligand binding site [chemical binding]; other site 441770001532 putative NAD(P) binding site [chemical binding]; other site 441770001533 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 441770001534 Hemerythrin; Region: Hemerythrin; cd12107 441770001535 Fe binding site [ion binding]; other site 441770001536 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 441770001537 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 441770001538 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 441770001539 Amino acid permease; Region: AA_permease_2; pfam13520 441770001540 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 441770001541 AsnC family; Region: AsnC_trans_reg; pfam01037 441770001542 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 441770001543 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 441770001544 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 441770001545 Spore germination protein; Region: Spore_permease; cl17796 441770001546 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 441770001547 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 441770001548 trimer interface [polypeptide binding]; other site 441770001549 putative metal binding site [ion binding]; other site 441770001550 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 441770001551 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 441770001552 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 441770001553 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441770001554 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 441770001555 Soluble P-type ATPase [General function prediction only]; Region: COG4087 441770001556 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 441770001557 Chromate transporter; Region: Chromate_transp; pfam02417 441770001558 Chromate transporter; Region: Chromate_transp; pfam02417 441770001559 PemK-like protein; Region: PemK; pfam02452 441770001560 Protein of unknown function (DUF327); Region: DUF327; pfam03885 441770001561 NAD synthetase; Reviewed; Region: nadE; PRK02628 441770001562 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 441770001563 multimer interface [polypeptide binding]; other site 441770001564 active site 441770001565 catalytic triad [active] 441770001566 protein interface 1 [polypeptide binding]; other site 441770001567 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 441770001568 homodimer interface [polypeptide binding]; other site 441770001569 NAD binding pocket [chemical binding]; other site 441770001570 ATP binding pocket [chemical binding]; other site 441770001571 Mg binding site [ion binding]; other site 441770001572 active-site loop [active] 441770001573 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 441770001574 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 441770001575 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 441770001576 CAAX protease self-immunity; Region: Abi; pfam02517 441770001577 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 441770001578 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 441770001579 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 441770001580 active site 441770001581 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441770001582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770001583 non-specific DNA binding site [nucleotide binding]; other site 441770001584 salt bridge; other site 441770001585 sequence-specific DNA binding site [nucleotide binding]; other site 441770001586 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 441770001587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770001588 Coenzyme A binding pocket [chemical binding]; other site 441770001589 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 441770001590 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 441770001591 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 441770001592 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 441770001593 Carbon starvation protein CstA; Region: CstA; pfam02554 441770001594 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 441770001595 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 441770001596 Cache domain; Region: Cache_1; pfam02743 441770001597 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441770001598 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770001599 dimer interface [polypeptide binding]; other site 441770001600 putative CheW interface [polypeptide binding]; other site 441770001601 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 441770001602 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 441770001603 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 441770001604 SEC-C motif; Region: SEC-C; pfam02810 441770001605 Predicted transcriptional regulators [Transcription]; Region: COG1725 441770001606 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770001607 DNA-binding site [nucleotide binding]; DNA binding site 441770001608 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 441770001609 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441770001610 Walker A/P-loop; other site 441770001611 ATP binding site [chemical binding]; other site 441770001612 Q-loop/lid; other site 441770001613 ABC transporter signature motif; other site 441770001614 Walker B; other site 441770001615 D-loop; other site 441770001616 H-loop/switch region; other site 441770001617 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 441770001618 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 441770001619 Walker A/P-loop; other site 441770001620 ATP binding site [chemical binding]; other site 441770001621 Q-loop/lid; other site 441770001622 ABC transporter signature motif; other site 441770001623 Walker B; other site 441770001624 D-loop; other site 441770001625 H-loop/switch region; other site 441770001626 TOBE domain; Region: TOBE_2; pfam08402 441770001627 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 441770001628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770001629 dimer interface [polypeptide binding]; other site 441770001630 conserved gate region; other site 441770001631 putative PBP binding loops; other site 441770001632 ABC-ATPase subunit interface; other site 441770001633 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 441770001634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770001635 dimer interface [polypeptide binding]; other site 441770001636 conserved gate region; other site 441770001637 putative PBP binding loops; other site 441770001638 ABC-ATPase subunit interface; other site 441770001639 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 441770001640 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 441770001641 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 441770001642 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441770001643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770001644 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 441770001645 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 441770001646 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 441770001647 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441770001648 Zn2+ binding site [ion binding]; other site 441770001649 Mg2+ binding site [ion binding]; other site 441770001650 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 441770001651 CAAX protease self-immunity; Region: Abi; pfam02517 441770001652 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 441770001653 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 441770001654 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 441770001655 putative tRNA-binding site [nucleotide binding]; other site 441770001656 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 441770001657 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 441770001658 Catalytic site [active] 441770001659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770001660 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 441770001661 active site 441770001662 phosphorylation site [posttranslational modification] 441770001663 intermolecular recognition site; other site 441770001664 dimerization interface [polypeptide binding]; other site 441770001665 LytTr DNA-binding domain; Region: LytTR; smart00850 441770001666 Cys-rich peptide, Clo7bot family; Region: Clo7Bot_mod_Cys; TIGR04333 441770001667 Cys-rich peptide, Clo7bot family; Region: Clo7Bot_mod_Cys; TIGR04333 441770001668 Cys-rich peptide, Clo7bot family; Region: Clo7Bot_mod_Cys; TIGR04333 441770001669 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 441770001670 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770001671 FeS/SAM binding site; other site 441770001672 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 441770001673 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 441770001674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770001675 Coenzyme A binding pocket [chemical binding]; other site 441770001676 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441770001677 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441770001678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770001679 Walker A/P-loop; other site 441770001680 ATP binding site [chemical binding]; other site 441770001681 Q-loop/lid; other site 441770001682 ABC transporter signature motif; other site 441770001683 Walker B; other site 441770001684 D-loop; other site 441770001685 H-loop/switch region; other site 441770001686 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 441770001687 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 441770001688 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 441770001689 FtsX-like permease family; Region: FtsX; pfam02687 441770001690 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 441770001691 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 441770001692 FtsX-like permease family; Region: FtsX; pfam02687 441770001693 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441770001694 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441770001695 Walker A/P-loop; other site 441770001696 ATP binding site [chemical binding]; other site 441770001697 Q-loop/lid; other site 441770001698 ABC transporter signature motif; other site 441770001699 Walker B; other site 441770001700 D-loop; other site 441770001701 H-loop/switch region; other site 441770001702 EDD domain protein, DegV family; Region: DegV; TIGR00762 441770001703 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 441770001704 hypothetical protein; Provisional; Region: PRK04164 441770001705 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 441770001706 Sulfatase; Region: Sulfatase; pfam00884 441770001707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770001708 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 441770001709 Walker A motif; other site 441770001710 ATP binding site [chemical binding]; other site 441770001711 Walker B motif; other site 441770001712 arginine finger; other site 441770001713 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441770001714 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 441770001715 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 441770001716 Nucleoside recognition; Region: Gate; pfam07670 441770001717 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 441770001718 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 441770001719 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 441770001720 putative dimer interface [polypeptide binding]; other site 441770001721 putative anticodon binding site; other site 441770001722 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 441770001723 homodimer interface [polypeptide binding]; other site 441770001724 motif 1; other site 441770001725 motif 2; other site 441770001726 active site 441770001727 motif 3; other site 441770001728 Predicted transcriptional regulators [Transcription]; Region: COG1695 441770001729 Transcriptional regulator PadR-like family; Region: PadR; cl17335 441770001730 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 441770001731 LytTr DNA-binding domain; Region: LytTR; smart00850 441770001732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770001733 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441770001734 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770001735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 441770001736 CAAX protease self-immunity; Region: Abi; pfam02517 441770001737 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441770001738 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770001739 non-specific DNA binding site [nucleotide binding]; other site 441770001740 salt bridge; other site 441770001741 sequence-specific DNA binding site [nucleotide binding]; other site 441770001742 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 441770001743 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 441770001744 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770001745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770001746 active site 441770001747 phosphorylation site [posttranslational modification] 441770001748 intermolecular recognition site; other site 441770001749 dimerization interface [polypeptide binding]; other site 441770001750 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770001751 DNA binding site [nucleotide binding] 441770001752 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770001753 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441770001754 dimerization interface [polypeptide binding]; other site 441770001755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770001756 dimer interface [polypeptide binding]; other site 441770001757 phosphorylation site [posttranslational modification] 441770001758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770001759 ATP binding site [chemical binding]; other site 441770001760 Mg2+ binding site [ion binding]; other site 441770001761 G-X-G motif; other site 441770001762 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 441770001763 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 441770001764 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770001765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770001766 active site 441770001767 phosphorylation site [posttranslational modification] 441770001768 intermolecular recognition site; other site 441770001769 dimerization interface [polypeptide binding]; other site 441770001770 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770001771 DNA binding site [nucleotide binding] 441770001772 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770001773 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770001774 dimer interface [polypeptide binding]; other site 441770001775 phosphorylation site [posttranslational modification] 441770001776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770001777 ATP binding site [chemical binding]; other site 441770001778 Mg2+ binding site [ion binding]; other site 441770001779 G-X-G motif; other site 441770001780 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 441770001781 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 441770001782 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441770001783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770001784 active site 441770001785 phosphorylation site [posttranslational modification] 441770001786 intermolecular recognition site; other site 441770001787 dimerization interface [polypeptide binding]; other site 441770001788 YcbB domain; Region: YcbB; pfam08664 441770001789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770001790 ATP binding site [chemical binding]; other site 441770001791 Mg2+ binding site [ion binding]; other site 441770001792 G-X-G motif; other site 441770001793 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 441770001794 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 441770001795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441770001796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770001797 S-adenosylmethionine binding site [chemical binding]; other site 441770001798 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441770001799 dimerization interface [polypeptide binding]; other site 441770001800 putative Zn2+ binding site [ion binding]; other site 441770001801 putative DNA binding site [nucleotide binding]; other site 441770001802 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441770001803 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441770001804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770001805 Walker A/P-loop; other site 441770001806 ATP binding site [chemical binding]; other site 441770001807 Q-loop/lid; other site 441770001808 ABC transporter signature motif; other site 441770001809 Walker B; other site 441770001810 D-loop; other site 441770001811 H-loop/switch region; other site 441770001812 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 441770001813 Chloramphenicol acetyltransferase; Region: CAT; smart01059 441770001814 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441770001815 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441770001816 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770001817 Coenzyme A binding pocket [chemical binding]; other site 441770001818 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 441770001819 dimer interface [polypeptide binding]; other site 441770001820 putative tRNA-binding site [nucleotide binding]; other site 441770001821 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 441770001822 Helix-turn-helix domain; Region: HTH_18; pfam12833 441770001823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770001824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770001825 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 441770001826 non-specific DNA binding site [nucleotide binding]; other site 441770001827 salt bridge; other site 441770001828 sequence-specific DNA binding site [nucleotide binding]; other site 441770001829 Cupin domain; Region: Cupin_2; pfam07883 441770001830 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 441770001831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770001832 ABC transporter; Region: ABC_tran; pfam00005 441770001833 Q-loop/lid; other site 441770001834 ABC transporter signature motif; other site 441770001835 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 441770001836 Walker B; other site 441770001837 D-loop; other site 441770001838 H-loop/switch region; other site 441770001839 LytTr DNA-binding domain; Region: LytTR; pfam04397 441770001840 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 441770001841 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441770001842 Walker A/P-loop; other site 441770001843 ATP binding site [chemical binding]; other site 441770001844 Q-loop/lid; other site 441770001845 ABC transporter signature motif; other site 441770001846 Walker B; other site 441770001847 D-loop; other site 441770001848 H-loop/switch region; other site 441770001849 allantoate amidohydrolase; Reviewed; Region: PRK09290 441770001850 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 441770001851 active site 441770001852 metal binding site [ion binding]; metal-binding site 441770001853 dimer interface [polypeptide binding]; other site 441770001854 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 441770001855 MutS domain III; Region: MutS_III; pfam05192 441770001856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770001857 Walker A/P-loop; other site 441770001858 ATP binding site [chemical binding]; other site 441770001859 Q-loop/lid; other site 441770001860 ABC transporter signature motif; other site 441770001861 Walker B; other site 441770001862 D-loop; other site 441770001863 H-loop/switch region; other site 441770001864 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 441770001865 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 441770001866 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 441770001867 Protein of unknown function (DUF454); Region: DUF454; cl01063 441770001868 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 441770001869 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 441770001870 minor groove reading motif; other site 441770001871 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 441770001872 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770001873 DNA-binding site [nucleotide binding]; DNA binding site 441770001874 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770001875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770001876 homodimer interface [polypeptide binding]; other site 441770001877 catalytic residue [active] 441770001878 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 441770001879 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 441770001880 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 441770001881 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 441770001882 ATP binding site [chemical binding]; other site 441770001883 Mg++ binding site [ion binding]; other site 441770001884 motif III; other site 441770001885 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441770001886 nucleotide binding region [chemical binding]; other site 441770001887 ATP-binding site [chemical binding]; other site 441770001888 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 441770001889 diiron binding motif [ion binding]; other site 441770001890 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441770001891 MarR family; Region: MarR_2; pfam12802 441770001892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441770001893 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441770001894 putative substrate translocation pore; other site 441770001895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441770001896 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 441770001897 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 441770001898 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441770001899 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441770001900 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 441770001901 dimerization interface [polypeptide binding]; other site 441770001902 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 441770001903 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 441770001904 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 441770001905 putative active site [active] 441770001906 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 441770001907 PLD-like domain; Region: PLDc_2; pfam13091 441770001908 putative homodimer interface [polypeptide binding]; other site 441770001909 putative active site [active] 441770001910 catalytic site [active] 441770001911 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 441770001912 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441770001913 ATP binding site [chemical binding]; other site 441770001914 putative Mg++ binding site [ion binding]; other site 441770001915 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441770001916 nucleotide binding region [chemical binding]; other site 441770001917 ATP-binding site [chemical binding]; other site 441770001918 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 441770001919 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 441770001920 active site 441770001921 8-oxo-dGMP binding site [chemical binding]; other site 441770001922 nudix motif; other site 441770001923 metal binding site [ion binding]; metal-binding site 441770001924 transcriptional antiterminator BglG; Provisional; Region: PRK09772 441770001925 CAT RNA binding domain; Region: CAT_RBD; smart01061 441770001926 PRD domain; Region: PRD; pfam00874 441770001927 PRD domain; Region: PRD; pfam00874 441770001928 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 441770001929 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441770001930 active site turn [active] 441770001931 phosphorylation site [posttranslational modification] 441770001932 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441770001933 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 441770001934 HPr interaction site; other site 441770001935 glycerol kinase (GK) interaction site [polypeptide binding]; other site 441770001936 active site 441770001937 phosphorylation site [posttranslational modification] 441770001938 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 441770001939 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 441770001940 active site 441770001941 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 441770001942 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441770001943 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441770001944 ligand binding site [chemical binding]; other site 441770001945 flexible hinge region; other site 441770001946 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 441770001947 putative switch regulator; other site 441770001948 non-specific DNA interactions [nucleotide binding]; other site 441770001949 DNA binding site [nucleotide binding] 441770001950 sequence specific DNA binding site [nucleotide binding]; other site 441770001951 putative cAMP binding site [chemical binding]; other site 441770001952 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 441770001953 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441770001954 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 441770001955 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 441770001956 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 441770001957 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 441770001958 Family of unknown function (DUF438); Region: DUF438; pfam04282 441770001959 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 441770001960 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 441770001961 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441770001962 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 441770001963 TM-ABC transporter signature motif; other site 441770001964 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 441770001965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770001966 Walker A/P-loop; other site 441770001967 ATP binding site [chemical binding]; other site 441770001968 Q-loop/lid; other site 441770001969 ABC transporter signature motif; other site 441770001970 Walker B; other site 441770001971 D-loop; other site 441770001972 H-loop/switch region; other site 441770001973 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 441770001974 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 441770001975 zinc binding site [ion binding]; other site 441770001976 putative ligand binding site [chemical binding]; other site 441770001977 RNA polymerase factor sigma-70; Validated; Region: PRK06811 441770001978 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441770001979 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 441770001980 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 441770001981 FMN binding site [chemical binding]; other site 441770001982 active site 441770001983 catalytic residues [active] 441770001984 substrate binding site [chemical binding]; other site 441770001985 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 441770001986 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 441770001987 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 441770001988 HsdM N-terminal domain; Region: HsdM_N; pfam12161 441770001989 Methyltransferase domain; Region: Methyltransf_26; pfam13659 441770001990 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 441770001991 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 441770001992 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 441770001993 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 441770001994 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 441770001995 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 441770001996 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 441770001997 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441770001998 ATP binding site [chemical binding]; other site 441770001999 putative Mg++ binding site [ion binding]; other site 441770002000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 441770002001 nucleotide binding region [chemical binding]; other site 441770002002 ATP-binding site [chemical binding]; other site 441770002003 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 441770002004 Part of AAA domain; Region: AAA_19; pfam13245 441770002005 Family description; Region: UvrD_C_2; pfam13538 441770002006 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548 441770002007 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441770002008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770002009 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 441770002010 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 441770002011 intersubunit interface [polypeptide binding]; other site 441770002012 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 441770002013 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441770002014 ABC-ATPase subunit interface; other site 441770002015 dimer interface [polypeptide binding]; other site 441770002016 putative PBP binding regions; other site 441770002017 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 441770002018 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441770002019 ABC-ATPase subunit interface; other site 441770002020 dimer interface [polypeptide binding]; other site 441770002021 putative PBP binding regions; other site 441770002022 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 441770002023 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 441770002024 Walker A/P-loop; other site 441770002025 ATP binding site [chemical binding]; other site 441770002026 Q-loop/lid; other site 441770002027 ABC transporter signature motif; other site 441770002028 Walker B; other site 441770002029 D-loop; other site 441770002030 H-loop/switch region; other site 441770002031 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441770002032 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 441770002033 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 441770002034 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 441770002035 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 441770002036 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316 441770002037 Cache domain; Region: Cache_1; pfam02743 441770002038 HAMP domain; Region: HAMP; pfam00672 441770002039 dimerization interface [polypeptide binding]; other site 441770002040 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770002041 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441770002042 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770002043 dimer interface [polypeptide binding]; other site 441770002044 putative CheW interface [polypeptide binding]; other site 441770002045 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 441770002046 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 441770002047 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 441770002048 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 441770002049 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 441770002050 glycine cleavage system protein H; Provisional; Region: PRK13380 441770002051 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 441770002052 lipoyl attachment site [posttranslational modification]; other site 441770002053 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 441770002054 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 441770002055 tetramer interface [polypeptide binding]; other site 441770002056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770002057 catalytic residue [active] 441770002058 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 441770002059 tetramer interface [polypeptide binding]; other site 441770002060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770002061 catalytic residue [active] 441770002062 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 441770002063 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441770002064 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 441770002065 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 441770002066 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 441770002067 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 441770002068 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 441770002069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770002070 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 441770002071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 441770002072 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 441770002073 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 441770002074 DNA binding residues [nucleotide binding] 441770002075 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 441770002076 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 441770002077 DNA binding residues [nucleotide binding] 441770002078 dimer interface [polypeptide binding]; other site 441770002079 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 441770002080 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441770002081 Walker A/P-loop; other site 441770002082 ATP binding site [chemical binding]; other site 441770002083 Q-loop/lid; other site 441770002084 ABC transporter signature motif; other site 441770002085 Walker B; other site 441770002086 D-loop; other site 441770002087 H-loop/switch region; other site 441770002088 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 441770002089 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 441770002090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770002091 Walker A/P-loop; other site 441770002092 ATP binding site [chemical binding]; other site 441770002093 Q-loop/lid; other site 441770002094 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 441770002095 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 441770002096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770002097 Walker A/P-loop; other site 441770002098 ATP binding site [chemical binding]; other site 441770002099 Q-loop/lid; other site 441770002100 ABC transporter signature motif; other site 441770002101 Walker B; other site 441770002102 D-loop; other site 441770002103 H-loop/switch region; other site 441770002104 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 441770002105 Part of AAA domain; Region: AAA_19; pfam13245 441770002106 Family description; Region: UvrD_C_2; pfam13538 441770002107 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 441770002108 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441770002109 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770002110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 441770002111 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 441770002112 EamA-like transporter family; Region: EamA; pfam00892 441770002113 EamA-like transporter family; Region: EamA; pfam00892 441770002114 TfoX C-terminal domain; Region: TfoX_C; pfam04994 441770002115 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 441770002116 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 441770002117 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 441770002118 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 441770002119 active site 441770002120 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441770002121 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770002122 dimer interface [polypeptide binding]; other site 441770002123 putative CheW interface [polypeptide binding]; other site 441770002124 Mor transcription activator family; Region: Mor; cl02360 441770002125 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 441770002126 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441770002127 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441770002128 ABC transporter; Region: ABC_tran_2; pfam12848 441770002129 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441770002130 WYL domain; Region: WYL; pfam13280 441770002131 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 441770002132 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 441770002133 conserved cys residue [active] 441770002134 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 441770002135 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 441770002136 dimer interface [polypeptide binding]; other site 441770002137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770002138 catalytic residue [active] 441770002139 S-ribosylhomocysteinase; Provisional; Region: PRK02260 441770002140 cystathionine beta-lyase; Provisional; Region: PRK07671 441770002141 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 441770002142 homodimer interface [polypeptide binding]; other site 441770002143 substrate-cofactor binding pocket; other site 441770002144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770002145 catalytic residue [active] 441770002146 Methyltransferase domain; Region: Methyltransf_31; pfam13847 441770002147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770002148 S-adenosylmethionine binding site [chemical binding]; other site 441770002149 Glyco_18 domain; Region: Glyco_18; smart00636 441770002150 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 441770002151 active site 441770002152 Chitinase C; Region: ChiC; pfam06483 441770002153 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441770002154 metal-binding site [ion binding] 441770002155 Domain of unknown function (DUF4071); Region: DUF4071; pfam13281 441770002156 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 441770002157 Domain of unknown function (DUF955); Region: DUF955; pfam06114 441770002158 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441770002159 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770002160 non-specific DNA binding site [nucleotide binding]; other site 441770002161 salt bridge; other site 441770002162 sequence-specific DNA binding site [nucleotide binding]; other site 441770002163 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770002164 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441770002165 non-specific DNA binding site [nucleotide binding]; other site 441770002166 salt bridge; other site 441770002167 sequence-specific DNA binding site [nucleotide binding]; other site 441770002168 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 441770002169 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 441770002170 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441770002171 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 441770002172 DNA binding residues [nucleotide binding] 441770002173 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 441770002174 four helix bundle protein; Region: TIGR02436 441770002175 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 441770002176 active site 441770002177 metal binding site [ion binding]; metal-binding site 441770002178 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 441770002179 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 441770002180 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 441770002181 amidase catalytic site [active] 441770002182 Zn binding residues [ion binding]; other site 441770002183 substrate binding site [chemical binding]; other site 441770002184 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441770002185 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 441770002186 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 441770002187 putative active site [active] 441770002188 Bacterial SH3 domain; Region: SH3_3; pfam08239 441770002189 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441770002190 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 441770002191 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 441770002192 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 441770002193 Low molecular weight phosphatase family; Region: LMWPc; cl00105 441770002194 active site 441770002195 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 441770002196 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441770002197 dimerization interface [polypeptide binding]; other site 441770002198 putative DNA binding site [nucleotide binding]; other site 441770002199 putative Zn2+ binding site [ion binding]; other site 441770002200 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 441770002201 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 441770002202 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 441770002203 P loop; other site 441770002204 Nucleotide binding site [chemical binding]; other site 441770002205 DTAP/Switch II; other site 441770002206 Switch I; other site 441770002207 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 441770002208 P loop; other site 441770002209 Nucleotide binding site [chemical binding]; other site 441770002210 DTAP/Switch II; other site 441770002211 Switch I; other site 441770002212 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 441770002213 arsenical-resistance protein; Region: acr3; TIGR00832 441770002214 Methyltransferase domain; Region: Methyltransf_31; pfam13847 441770002215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770002216 S-adenosylmethionine binding site [chemical binding]; other site 441770002217 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 441770002218 catalytic core [active] 441770002219 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441770002220 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441770002221 Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205 441770002222 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441770002223 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770002224 non-specific DNA binding site [nucleotide binding]; other site 441770002225 salt bridge; other site 441770002226 sequence-specific DNA binding site [nucleotide binding]; other site 441770002227 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441770002228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770002229 Walker A/P-loop; other site 441770002230 ATP binding site [chemical binding]; other site 441770002231 Q-loop/lid; other site 441770002232 ABC transporter signature motif; other site 441770002233 Walker B; other site 441770002234 D-loop; other site 441770002235 H-loop/switch region; other site 441770002236 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 441770002237 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 441770002238 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 441770002239 dimerization interface [polypeptide binding]; other site 441770002240 active site 441770002241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770002242 S-adenosylmethionine binding site [chemical binding]; other site 441770002243 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 441770002244 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 441770002245 dimer interface [polypeptide binding]; other site 441770002246 substrate binding site [chemical binding]; other site 441770002247 ATP binding site [chemical binding]; other site 441770002248 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 441770002249 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441770002250 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441770002251 Walker A/P-loop; other site 441770002252 ATP binding site [chemical binding]; other site 441770002253 Q-loop/lid; other site 441770002254 ABC transporter signature motif; other site 441770002255 Walker B; other site 441770002256 D-loop; other site 441770002257 H-loop/switch region; other site 441770002258 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770002259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770002260 active site 441770002261 phosphorylation site [posttranslational modification] 441770002262 intermolecular recognition site; other site 441770002263 dimerization interface [polypeptide binding]; other site 441770002264 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770002265 DNA binding site [nucleotide binding] 441770002266 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441770002267 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770002268 Walker A/P-loop; other site 441770002269 ATP binding site [chemical binding]; other site 441770002270 Q-loop/lid; other site 441770002271 ABC transporter signature motif; other site 441770002272 Walker B; other site 441770002273 D-loop; other site 441770002274 H-loop/switch region; other site 441770002275 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 441770002276 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 441770002277 Helix-turn-helix domain; Region: HTH_18; pfam12833 441770002278 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770002279 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 441770002280 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770002281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770002282 dimer interface [polypeptide binding]; other site 441770002283 phosphorylation site [posttranslational modification] 441770002284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770002285 ATP binding site [chemical binding]; other site 441770002286 Mg2+ binding site [ion binding]; other site 441770002287 G-X-G motif; other site 441770002288 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 441770002289 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441770002290 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441770002291 Walker A/P-loop; other site 441770002292 ATP binding site [chemical binding]; other site 441770002293 Q-loop/lid; other site 441770002294 ABC transporter signature motif; other site 441770002295 Walker B; other site 441770002296 D-loop; other site 441770002297 H-loop/switch region; other site 441770002298 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 441770002299 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 441770002300 FtsX-like permease family; Region: FtsX; pfam02687 441770002301 FtsX-like permease family; Region: FtsX; pfam02687 441770002302 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770002303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770002304 active site 441770002305 phosphorylation site [posttranslational modification] 441770002306 intermolecular recognition site; other site 441770002307 dimerization interface [polypeptide binding]; other site 441770002308 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770002309 DNA binding site [nucleotide binding] 441770002310 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770002311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770002312 dimer interface [polypeptide binding]; other site 441770002313 phosphorylation site [posttranslational modification] 441770002314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770002315 ATP binding site [chemical binding]; other site 441770002316 Mg2+ binding site [ion binding]; other site 441770002317 G-X-G motif; other site 441770002318 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 441770002319 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 441770002320 dihydrodipicolinate reductase; Provisional; Region: PRK00048 441770002321 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 441770002322 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 441770002323 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 441770002324 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 441770002325 active site residue [active] 441770002326 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 441770002327 active site residue [active] 441770002328 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 441770002329 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 441770002330 Clostridium enterotoxin; Region: Clenterotox; pfam03505 441770002331 Clostridium enterotoxin; Region: Clenterotox; pfam03505 441770002332 Clostridium botulinum HA-17 protein; Region: Botulinum_HA-17; pfam05588 441770002333 Ricin-type beta-trefoil; Region: RICIN; smart00458 441770002334 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 441770002335 Ricin-type beta-trefoil; Region: RICIN; smart00458 441770002336 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 441770002337 putative sugar binding sites [chemical binding]; other site 441770002338 Q-X-W motif; other site 441770002339 clostridium toxin-associated regulator BotR; Region: P21_Cbot; TIGR03209 441770002340 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 441770002341 DNA binding residues [nucleotide binding] 441770002342 Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742 441770002343 Clostridium neurotoxin, Translocation domain; Region: Toxin_trans; pfam07952 441770002344 Clostridium neurotoxin, N-terminal receptor binding; Region: Toxin_R_bind_N; pfam07953 441770002345 Nontoxic nonhaemagglutinin C-terminal; Region: NTNH_C; pfam08470 441770002346 Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742 441770002347 Clostridium neurotoxin, Translocation domain; Region: Toxin_trans; pfam07952 441770002348 Clostridium neurotoxin, N-terminal receptor binding; Region: Toxin_R_bind_N; pfam07953 441770002349 Clostridium neurotoxin, C-terminal receptor binding; Region: Toxin_R_bind_C; pfam07951 441770002350 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 441770002351 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 441770002352 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 441770002353 active site 441770002354 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 441770002355 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 441770002356 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441770002357 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770002358 dimer interface [polypeptide binding]; other site 441770002359 putative CheW interface [polypeptide binding]; other site 441770002360 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 441770002361 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 441770002362 FeoA domain; Region: FeoA; pfam04023 441770002363 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 441770002364 catalytic core [active] 441770002365 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 441770002366 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 441770002367 VanW like protein; Region: VanW; pfam04294 441770002368 G5 domain; Region: G5; pfam07501 441770002369 cobalamin synthase; Reviewed; Region: cobS; PRK00235 441770002370 AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586 441770002371 Coat F domain; Region: Coat_F; pfam07875 441770002372 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 441770002373 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 441770002374 NodB motif; other site 441770002375 putative active site [active] 441770002376 putative catalytic site [active] 441770002377 putative Zn binding site [ion binding]; other site 441770002378 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 441770002379 active site 441770002380 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 441770002381 dihydropteroate synthase; Region: DHPS; TIGR01496 441770002382 substrate binding pocket [chemical binding]; other site 441770002383 dimer interface [polypeptide binding]; other site 441770002384 inhibitor binding site; inhibition site 441770002385 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 441770002386 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 441770002387 catalytic center binding site [active] 441770002388 ATP binding site [chemical binding]; other site 441770002389 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 441770002390 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 441770002391 putative dimer interface [polypeptide binding]; other site 441770002392 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 441770002393 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 441770002394 DNA binding residues [nucleotide binding] 441770002395 dimer interface [polypeptide binding]; other site 441770002396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770002397 S-adenosylmethionine binding site [chemical binding]; other site 441770002398 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 441770002399 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 441770002400 inhibitor-cofactor binding pocket; inhibition site 441770002401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770002402 catalytic residue [active] 441770002403 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 441770002404 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 441770002405 inhibitor-cofactor binding pocket; inhibition site 441770002406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770002407 catalytic residue [active] 441770002408 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 441770002409 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 441770002410 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441770002411 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441770002412 DNA binding residues [nucleotide binding] 441770002413 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 441770002414 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 441770002415 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 441770002416 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 441770002417 Cadmium resistance transporter; Region: Cad; pfam03596 441770002418 Protein of unknown function (DUF523); Region: DUF523; pfam04463 441770002419 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 441770002420 MarR family; Region: MarR_2; cl17246 441770002421 AsnC family; Region: AsnC_trans_reg; pfam01037 441770002422 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 441770002423 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 441770002424 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 441770002425 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441770002426 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441770002427 Walker A/P-loop; other site 441770002428 ATP binding site [chemical binding]; other site 441770002429 Q-loop/lid; other site 441770002430 ABC transporter signature motif; other site 441770002431 Walker B; other site 441770002432 D-loop; other site 441770002433 H-loop/switch region; other site 441770002434 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441770002435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770002436 non-specific DNA binding site [nucleotide binding]; other site 441770002437 salt bridge; other site 441770002438 sequence-specific DNA binding site [nucleotide binding]; other site 441770002439 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 441770002440 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 441770002441 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 441770002442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 441770002443 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 441770002444 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 441770002445 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 441770002446 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 441770002447 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 441770002448 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 441770002449 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441770002450 dimerization interface [polypeptide binding]; other site 441770002451 putative DNA binding site [nucleotide binding]; other site 441770002452 putative Zn2+ binding site [ion binding]; other site 441770002453 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 441770002454 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 441770002455 DNA binding residues [nucleotide binding] 441770002456 dimer interface [polypeptide binding]; other site 441770002457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770002458 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 441770002459 Coenzyme A binding pocket [chemical binding]; other site 441770002460 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 441770002461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770002462 Coenzyme A binding pocket [chemical binding]; other site 441770002463 Pirin-related protein [General function prediction only]; Region: COG1741 441770002464 Pirin; Region: Pirin; pfam02678 441770002465 Predicted transcriptional regulators [Transcription]; Region: COG1733 441770002466 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 441770002467 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 441770002468 dimer interface [polypeptide binding]; other site 441770002469 FMN binding site [chemical binding]; other site 441770002470 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 441770002471 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 441770002472 Cupin; Region: Cupin_1; smart00835 441770002473 Cupin; Region: Cupin_1; smart00835 441770002474 TIGR00730 family protein; Region: TIGR00730 441770002475 Protein of unknown function, DUF606; Region: DUF606; pfam04657 441770002476 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441770002477 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441770002478 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 441770002479 dimerization interface [polypeptide binding]; other site 441770002480 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 441770002481 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770002482 Coenzyme A binding pocket [chemical binding]; other site 441770002483 Protein of unknown function, DUF606; Region: DUF606; pfam04657 441770002484 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441770002485 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 441770002486 putative switch regulator; other site 441770002487 DNA binding site [nucleotide binding] 441770002488 sequence specific DNA binding site [nucleotide binding]; other site 441770002489 putative cAMP binding site [chemical binding]; other site 441770002490 Predicted transcriptional regulator [Transcription]; Region: COG2378 441770002491 HTH domain; Region: HTH_11; pfam08279 441770002492 WYL domain; Region: WYL; pfam13280 441770002493 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 441770002494 Uncharacterized conserved protein [Function unknown]; Region: COG2966 441770002495 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 441770002496 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 441770002497 active site 441770002498 catalytic residues [active] 441770002499 metal binding site [ion binding]; metal-binding site 441770002500 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 441770002501 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770002502 DNA-binding site [nucleotide binding]; DNA binding site 441770002503 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770002504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770002505 homodimer interface [polypeptide binding]; other site 441770002506 catalytic residue [active] 441770002507 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 441770002508 putative FMN binding site [chemical binding]; other site 441770002509 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 441770002510 transcriptional antiterminator BglG; Provisional; Region: PRK09772 441770002511 CAT RNA binding domain; Region: CAT_RBD; smart01061 441770002512 PRD domain; Region: PRD; pfam00874 441770002513 PRD domain; Region: PRD; pfam00874 441770002514 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 441770002515 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441770002516 active site turn [active] 441770002517 phosphorylation site [posttranslational modification] 441770002518 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441770002519 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 441770002520 HPr interaction site; other site 441770002521 glycerol kinase (GK) interaction site [polypeptide binding]; other site 441770002522 active site 441770002523 phosphorylation site [posttranslational modification] 441770002524 beta-galactosidase; Region: BGL; TIGR03356 441770002525 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 441770002526 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 441770002527 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 441770002528 Mg++ binding site [ion binding]; other site 441770002529 putative catalytic motif [active] 441770002530 putative substrate binding site [chemical binding]; other site 441770002531 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441770002532 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770002533 non-specific DNA binding site [nucleotide binding]; other site 441770002534 sequence-specific DNA binding site [nucleotide binding]; other site 441770002535 salt bridge; other site 441770002536 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 441770002537 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 441770002538 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 441770002539 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 441770002540 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 441770002541 Multicopper oxidase; Region: Cu-oxidase; pfam00394 441770002542 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 441770002543 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 441770002544 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 441770002545 Predicted membrane protein [Function unknown]; Region: COG2510 441770002546 Predicted membrane protein [Function unknown]; Region: COG2510 441770002547 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 441770002548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 441770002549 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441770002550 YmaF family; Region: YmaF; pfam12788 441770002551 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 441770002552 Amino acid permease; Region: AA_permease_2; pfam13520 441770002553 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441770002554 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441770002555 Walker A/P-loop; other site 441770002556 ATP binding site [chemical binding]; other site 441770002557 Q-loop/lid; other site 441770002558 ABC transporter signature motif; other site 441770002559 Walker B; other site 441770002560 D-loop; other site 441770002561 H-loop/switch region; other site 441770002562 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 441770002563 FtsX-like permease family; Region: FtsX; pfam02687 441770002564 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770002565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770002566 active site 441770002567 phosphorylation site [posttranslational modification] 441770002568 intermolecular recognition site; other site 441770002569 dimerization interface [polypeptide binding]; other site 441770002570 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770002571 DNA binding site [nucleotide binding] 441770002572 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770002573 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441770002574 dimerization interface [polypeptide binding]; other site 441770002575 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770002576 dimer interface [polypeptide binding]; other site 441770002577 phosphorylation site [posttranslational modification] 441770002578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770002579 ATP binding site [chemical binding]; other site 441770002580 Mg2+ binding site [ion binding]; other site 441770002581 G-X-G motif; other site 441770002582 BioY family; Region: BioY; pfam02632 441770002583 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 441770002584 Sel1 repeat; Region: Sel1; pfam08238 441770002585 Sel1-like repeats; Region: SEL1; smart00671 441770002586 Sel1-like repeats; Region: SEL1; smart00671 441770002587 Sel1-like repeats; Region: SEL1; smart00671 441770002588 putative acetyltransferase YhhY; Provisional; Region: PRK10140 441770002589 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770002590 Coenzyme A binding pocket [chemical binding]; other site 441770002591 LexA repressor; Validated; Region: PRK00215 441770002592 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 441770002593 Catalytic site [active] 441770002594 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 441770002595 homotrimer interface [polypeptide binding]; other site 441770002596 Walker A motif; other site 441770002597 GTP binding site [chemical binding]; other site 441770002598 Walker B motif; other site 441770002599 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 441770002600 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 441770002601 DNA binding residues [nucleotide binding] 441770002602 dimer interface [polypeptide binding]; other site 441770002603 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 441770002604 cobyric acid synthase; Provisional; Region: PRK00784 441770002605 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441770002606 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441770002607 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 441770002608 catalytic triad [active] 441770002609 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 441770002610 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 441770002611 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770002612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770002613 homodimer interface [polypeptide binding]; other site 441770002614 catalytic residue [active] 441770002615 cobalt transport protein CbiM; Validated; Region: PRK08319 441770002616 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 441770002617 cobalt transport protein CbiN; Provisional; Region: PRK02898 441770002618 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 441770002619 precorrin-2 dehydrogenase; Provisional; Region: PRK05562 441770002620 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 441770002621 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 441770002622 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 441770002623 domain interfaces; other site 441770002624 active site 441770002625 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 441770002626 active site 441770002627 SAM binding site [chemical binding]; other site 441770002628 homodimer interface [polypeptide binding]; other site 441770002629 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 441770002630 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 441770002631 active site 441770002632 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 441770002633 dimer interface [polypeptide binding]; other site 441770002634 active site 441770002635 Schiff base residues; other site 441770002636 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 441770002637 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441770002638 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 441770002639 catalytic triad [active] 441770002640 precorrin-8X methylmutase; Validated; Region: cbiC; PRK05575 441770002641 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 441770002642 CAAX protease self-immunity; Region: Abi; pfam02517 441770002643 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 441770002644 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 441770002645 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441770002646 Zn2+ binding site [ion binding]; other site 441770002647 Mg2+ binding site [ion binding]; other site 441770002648 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 441770002649 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 441770002650 DNA binding residues [nucleotide binding] 441770002651 dimer interface [polypeptide binding]; other site 441770002652 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 441770002653 Fic family protein [Function unknown]; Region: COG3177 441770002654 Fic/DOC family; Region: Fic; pfam02661 441770002655 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 441770002656 FMN binding site [chemical binding]; other site 441770002657 dimer interface [polypeptide binding]; other site 441770002658 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 441770002659 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 441770002660 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 441770002661 active site 441770002662 putative homodimer interface [polypeptide binding]; other site 441770002663 SAM binding site [chemical binding]; other site 441770002664 CAAX protease self-immunity; Region: Abi; pfam02517 441770002665 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 441770002666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770002667 S-adenosylmethionine binding site [chemical binding]; other site 441770002668 hypothetical protein; Provisional; Region: PRK06771 441770002669 Isochorismatase family; Region: Isochorismatase; pfam00857 441770002670 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 441770002671 catalytic triad [active] 441770002672 conserved cis-peptide bond; other site 441770002673 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 441770002674 active site 441770002675 SAM binding site [chemical binding]; other site 441770002676 homodimer interface [polypeptide binding]; other site 441770002677 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 441770002678 active site 441770002679 SAM binding site [chemical binding]; other site 441770002680 homodimer interface [polypeptide binding]; other site 441770002681 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 441770002682 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 441770002683 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 441770002684 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 441770002685 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 441770002686 active site 441770002687 SAM binding site [chemical binding]; other site 441770002688 homodimer interface [polypeptide binding]; other site 441770002689 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 441770002690 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 441770002691 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 441770002692 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 441770002693 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 441770002694 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 441770002695 active site 441770002696 C-terminal domain interface [polypeptide binding]; other site 441770002697 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 441770002698 active site 441770002699 N-terminal domain interface [polypeptide binding]; other site 441770002700 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 441770002701 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 441770002702 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 441770002703 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 441770002704 homodimer interface [polypeptide binding]; other site 441770002705 Walker A motif; other site 441770002706 ATP binding site [chemical binding]; other site 441770002707 hydroxycobalamin binding site [chemical binding]; other site 441770002708 Walker B motif; other site 441770002709 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441770002710 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441770002711 ligand binding site [chemical binding]; other site 441770002712 flexible hinge region; other site 441770002713 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 441770002714 putative switch regulator; other site 441770002715 non-specific DNA interactions [nucleotide binding]; other site 441770002716 DNA binding site [nucleotide binding] 441770002717 sequence specific DNA binding site [nucleotide binding]; other site 441770002718 putative cAMP binding site [chemical binding]; other site 441770002719 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 441770002720 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 441770002721 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 441770002722 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 441770002723 FAD binding pocket [chemical binding]; other site 441770002724 FAD binding motif [chemical binding]; other site 441770002725 phosphate binding motif [ion binding]; other site 441770002726 beta-alpha-beta structure motif; other site 441770002727 NAD binding pocket [chemical binding]; other site 441770002728 Iron coordination center [ion binding]; other site 441770002729 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 441770002730 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 441770002731 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 441770002732 putative MPT binding site; other site 441770002733 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 441770002734 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441770002735 substrate binding pocket [chemical binding]; other site 441770002736 membrane-bound complex binding site; other site 441770002737 hinge residues; other site 441770002738 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 441770002739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770002740 dimer interface [polypeptide binding]; other site 441770002741 conserved gate region; other site 441770002742 putative PBP binding loops; other site 441770002743 ABC-ATPase subunit interface; other site 441770002744 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441770002745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770002746 Walker A/P-loop; other site 441770002747 ATP binding site [chemical binding]; other site 441770002748 Q-loop/lid; other site 441770002749 ABC transporter signature motif; other site 441770002750 Walker B; other site 441770002751 D-loop; other site 441770002752 H-loop/switch region; other site 441770002753 Domain of unknown function (DUF364); Region: DUF364; pfam04016 441770002754 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441770002755 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 441770002756 Walker A/P-loop; other site 441770002757 ATP binding site [chemical binding]; other site 441770002758 Q-loop/lid; other site 441770002759 ABC transporter signature motif; other site 441770002760 Walker B; other site 441770002761 D-loop; other site 441770002762 H-loop/switch region; other site 441770002763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770002764 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770002765 active site 441770002766 phosphorylation site [posttranslational modification] 441770002767 intermolecular recognition site; other site 441770002768 dimerization interface [polypeptide binding]; other site 441770002769 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770002770 DNA binding site [nucleotide binding] 441770002771 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770002772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770002773 dimer interface [polypeptide binding]; other site 441770002774 phosphorylation site [posttranslational modification] 441770002775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770002776 ATP binding site [chemical binding]; other site 441770002777 G-X-G motif; other site 441770002778 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 441770002779 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 441770002780 Walker A/P-loop; other site 441770002781 ATP binding site [chemical binding]; other site 441770002782 Q-loop/lid; other site 441770002783 ABC transporter signature motif; other site 441770002784 Walker B; other site 441770002785 D-loop; other site 441770002786 H-loop/switch region; other site 441770002787 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 441770002788 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441770002789 ABC-ATPase subunit interface; other site 441770002790 dimer interface [polypeptide binding]; other site 441770002791 putative PBP binding regions; other site 441770002792 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 441770002793 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 441770002794 putative ligand binding residues [chemical binding]; other site 441770002795 dihydroxyacetone kinase; Provisional; Region: PRK14479 441770002796 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 441770002797 DAK2 domain; Region: Dak2; pfam02734 441770002798 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 441770002799 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 441770002800 dimer interface [polypeptide binding]; other site 441770002801 active site 441770002802 metal binding site [ion binding]; metal-binding site 441770002803 Sensory domain found in PocR; Region: PocR; pfam10114 441770002804 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 441770002805 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770002806 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441770002807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770002808 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 441770002809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770002810 Coenzyme A binding pocket [chemical binding]; other site 441770002811 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770002812 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 441770002813 Coenzyme A binding pocket [chemical binding]; other site 441770002814 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 441770002815 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 441770002816 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 441770002817 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 441770002818 active site 441770002819 catalytic tetrad [active] 441770002820 TfoX N-terminal domain; Region: TfoX_N; pfam04993 441770002821 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 441770002822 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 441770002823 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 441770002824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770002825 Coenzyme A binding pocket [chemical binding]; other site 441770002826 Predicted transcriptional regulators [Transcription]; Region: COG1695 441770002827 Transcriptional regulator PadR-like family; Region: PadR; cl17335 441770002828 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 441770002829 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 441770002830 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 441770002831 active site 441770002832 purine riboside binding site [chemical binding]; other site 441770002833 Predicted membrane protein [Function unknown]; Region: COG1511 441770002834 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 441770002835 Predicted membrane protein [Function unknown]; Region: COG1511 441770002836 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 441770002837 Predicted membrane protein [Function unknown]; Region: COG1511 441770002838 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 441770002839 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 441770002840 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 441770002841 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 441770002842 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 441770002843 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441770002844 ATP binding site [chemical binding]; other site 441770002845 putative Mg++ binding site [ion binding]; other site 441770002846 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441770002847 nucleotide binding region [chemical binding]; other site 441770002848 ATP-binding site [chemical binding]; other site 441770002849 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 441770002850 HRDC domain; Region: HRDC; pfam00570 441770002851 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 441770002852 Rubrerythrin [Energy production and conversion]; Region: COG1592 441770002853 diiron binding motif [ion binding]; other site 441770002854 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 441770002855 active site 441770002856 metal binding site [ion binding]; metal-binding site 441770002857 homotetramer interface [polypeptide binding]; other site 441770002858 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441770002859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770002860 active site 441770002861 phosphorylation site [posttranslational modification] 441770002862 intermolecular recognition site; other site 441770002863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441770002864 TPR repeat; Region: TPR_11; pfam13414 441770002865 TPR motif; other site 441770002866 binding surface 441770002867 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 441770002868 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 441770002869 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 441770002870 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 441770002871 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 441770002872 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770002873 FeS/SAM binding site; other site 441770002874 Ycf46; Provisional; Region: ycf46; CHL00195 441770002875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770002876 Walker A motif; other site 441770002877 ATP binding site [chemical binding]; other site 441770002878 Walker B motif; other site 441770002879 arginine finger; other site 441770002880 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 441770002881 L-lactate permease; Region: Lactate_perm; cl00701 441770002882 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 441770002883 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 441770002884 Ligand binding site [chemical binding]; other site 441770002885 Electron transfer flavoprotein domain; Region: ETF; pfam01012 441770002886 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 441770002887 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 441770002888 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 441770002889 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 441770002890 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 441770002891 FAD binding domain; Region: FAD_binding_4; pfam01565 441770002892 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441770002893 Putative cyclase; Region: Cyclase; pfam04199 441770002894 aspartate aminotransferase; Provisional; Region: PRK06836 441770002895 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770002896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770002897 homodimer interface [polypeptide binding]; other site 441770002898 catalytic residue [active] 441770002899 Putative cyclase; Region: Cyclase; pfam04199 441770002900 Putative cyclase; Region: Cyclase; cl00814 441770002901 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 441770002902 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 441770002903 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 441770002904 DNA binding residues [nucleotide binding] 441770002905 drug binding residues [chemical binding]; other site 441770002906 dimer interface [polypeptide binding]; other site 441770002907 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 441770002908 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 441770002909 B3/4 domain; Region: B3_4; pfam03483 441770002910 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 441770002911 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 441770002912 Dimer interface [polypeptide binding]; other site 441770002913 anticodon binding site; other site 441770002914 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 441770002915 homodimer interface [polypeptide binding]; other site 441770002916 motif 1; other site 441770002917 motif 2; other site 441770002918 active site 441770002919 motif 3; other site 441770002920 flavodoxin; Provisional; Region: PRK06242 441770002921 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441770002922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441770002923 WHG domain; Region: WHG; pfam13305 441770002924 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 441770002925 dUMP phosphatase; Provisional; Region: PRK09449 441770002926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441770002927 motif II; other site 441770002928 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 441770002929 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441770002930 ligand binding site [chemical binding]; other site 441770002931 flexible hinge region; other site 441770002932 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 441770002933 putative switch regulator; other site 441770002934 DNA binding site [nucleotide binding] 441770002935 sequence specific DNA binding site [nucleotide binding]; other site 441770002936 putative cAMP binding site [chemical binding]; other site 441770002937 DJ-1 family protein; Region: not_thiJ; TIGR01383 441770002938 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 441770002939 conserved cys residue [active] 441770002940 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441770002941 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441770002942 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 441770002943 dimerization interface [polypeptide binding]; other site 441770002944 YoaP-like; Region: YoaP; pfam14268 441770002945 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 441770002946 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 441770002947 G1 box; other site 441770002948 GTP/Mg2+ binding site [chemical binding]; other site 441770002949 Switch I region; other site 441770002950 G2 box; other site 441770002951 G3 box; other site 441770002952 Switch II region; other site 441770002953 G4 box; other site 441770002954 G5 box; other site 441770002955 Nucleoside recognition; Region: Gate; pfam07670 441770002956 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 441770002957 Nucleoside recognition; Region: Gate; pfam07670 441770002958 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 441770002959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770002960 Coenzyme A binding pocket [chemical binding]; other site 441770002961 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 441770002962 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 441770002963 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 441770002964 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770002965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770002966 active site 441770002967 phosphorylation site [posttranslational modification] 441770002968 intermolecular recognition site; other site 441770002969 dimerization interface [polypeptide binding]; other site 441770002970 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770002971 DNA binding site [nucleotide binding] 441770002972 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770002973 dimer interface [polypeptide binding]; other site 441770002974 phosphorylation site [posttranslational modification] 441770002975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770002976 ATP binding site [chemical binding]; other site 441770002977 Mg2+ binding site [ion binding]; other site 441770002978 G-X-G motif; other site 441770002979 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 441770002980 Cytochrome P450; Region: p450; cl12078 441770002981 Cytochrome P450; Region: p450; cl12078 441770002982 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441770002983 metal-binding site [ion binding] 441770002984 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 441770002985 Family description; Region: DsbD_2; pfam13386 441770002986 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 441770002987 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 441770002988 Predicted membrane protein [Function unknown]; Region: COG3462 441770002989 Short C-terminal domain; Region: SHOCT; pfam09851 441770002990 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770002991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770002992 active site 441770002993 phosphorylation site [posttranslational modification] 441770002994 intermolecular recognition site; other site 441770002995 dimerization interface [polypeptide binding]; other site 441770002996 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770002997 DNA binding site [nucleotide binding] 441770002998 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770002999 HAMP domain; Region: HAMP; pfam00672 441770003000 dimerization interface [polypeptide binding]; other site 441770003001 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770003002 dimer interface [polypeptide binding]; other site 441770003003 phosphorylation site [posttranslational modification] 441770003004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770003005 ATP binding site [chemical binding]; other site 441770003006 Mg2+ binding site [ion binding]; other site 441770003007 G-X-G motif; other site 441770003008 A new structural DNA glycosylase; Region: AlkD_like; cd06561 441770003009 active site 441770003010 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770003011 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441770003012 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770003013 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 441770003014 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441770003015 ABC-ATPase subunit interface; other site 441770003016 dimer interface [polypeptide binding]; other site 441770003017 putative PBP binding regions; other site 441770003018 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441770003019 ABC-ATPase subunit interface; other site 441770003020 dimer interface [polypeptide binding]; other site 441770003021 putative PBP binding regions; other site 441770003022 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 441770003023 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 441770003024 Walker A/P-loop; other site 441770003025 ATP binding site [chemical binding]; other site 441770003026 Q-loop/lid; other site 441770003027 ABC transporter signature motif; other site 441770003028 Walker B; other site 441770003029 D-loop; other site 441770003030 H-loop/switch region; other site 441770003031 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 441770003032 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 441770003033 putative ligand binding residues [chemical binding]; other site 441770003034 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441770003035 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770003036 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441770003037 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441770003038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770003039 Walker A/P-loop; other site 441770003040 ATP binding site [chemical binding]; other site 441770003041 Q-loop/lid; other site 441770003042 ABC transporter signature motif; other site 441770003043 Walker B; other site 441770003044 D-loop; other site 441770003045 H-loop/switch region; other site 441770003046 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441770003047 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441770003048 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 441770003049 Walker A/P-loop; other site 441770003050 ATP binding site [chemical binding]; other site 441770003051 Q-loop/lid; other site 441770003052 ABC transporter signature motif; other site 441770003053 Walker B; other site 441770003054 D-loop; other site 441770003055 H-loop/switch region; other site 441770003056 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 441770003057 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 441770003058 ATP binding site [chemical binding]; other site 441770003059 Mg2+ binding site [ion binding]; other site 441770003060 G-X-G motif; other site 441770003061 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 441770003062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770003063 active site 441770003064 phosphorylation site [posttranslational modification] 441770003065 intermolecular recognition site; other site 441770003066 dimerization interface [polypeptide binding]; other site 441770003067 LytTr DNA-binding domain; Region: LytTR; smart00850 441770003068 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441770003069 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441770003070 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 441770003071 conserved repeat domain; Region: B_ant_repeat; TIGR01451 441770003072 Domain of unknown function DUF11; Region: DUF11; pfam01345 441770003073 Domain of unknown function DUF11; Region: DUF11; cl17728 441770003074 Domain of unknown function DUF11; Region: DUF11; pfam01345 441770003075 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 441770003076 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 441770003077 putative active site [active] 441770003078 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 441770003079 Interdomain contacts; other site 441770003080 Cytokine receptor motif; other site 441770003081 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 441770003082 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 441770003083 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 441770003084 catalytic residues [active] 441770003085 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 441770003086 Predicted membrane protein [Function unknown]; Region: COG4129 441770003087 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 441770003088 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 441770003089 Predicted Ser/Thr protein kinase [Signal transduction mechanisms]; Region: COG2112 441770003090 CAAX protease self-immunity; Region: Abi; pfam02517 441770003091 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 441770003092 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 441770003093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770003094 Walker A/P-loop; other site 441770003095 ATP binding site [chemical binding]; other site 441770003096 Q-loop/lid; other site 441770003097 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441770003098 ABC transporter signature motif; other site 441770003099 Walker B; other site 441770003100 ABC transporter; Region: ABC_tran_2; pfam12848 441770003101 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441770003102 Nucleoside recognition; Region: Gate; pfam07670 441770003103 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 441770003104 ArsC family; Region: ArsC; pfam03960 441770003105 catalytic residue [active] 441770003106 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770003107 FeS/SAM binding site; other site 441770003108 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 441770003109 Predicted dehydrogenase [General function prediction only]; Region: COG0579 441770003110 hydroxyglutarate oxidase; Provisional; Region: PRK11728 441770003111 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 441770003112 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 441770003113 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 441770003114 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 441770003115 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 441770003116 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 441770003117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441770003118 putative substrate translocation pore; other site 441770003119 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 441770003120 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 441770003121 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 441770003122 active site 441770003123 HIGH motif; other site 441770003124 KMSK motif region; other site 441770003125 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 441770003126 tRNA binding surface [nucleotide binding]; other site 441770003127 anticodon binding site; other site 441770003128 transaminase; Validated; Region: PRK07324 441770003129 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770003130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770003131 homodimer interface [polypeptide binding]; other site 441770003132 catalytic residue [active] 441770003133 FOG: CBS domain [General function prediction only]; Region: COG0517 441770003134 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 441770003135 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 441770003136 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 441770003137 G1 box; other site 441770003138 GTP/Mg2+ binding site [chemical binding]; other site 441770003139 Switch I region; other site 441770003140 G2 box; other site 441770003141 G3 box; other site 441770003142 Switch II region; other site 441770003143 G4 box; other site 441770003144 G5 box; other site 441770003145 Nucleoside recognition; Region: Gate; pfam07670 441770003146 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 441770003147 Nucleoside recognition; Region: Gate; pfam07670 441770003148 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 441770003149 PilZ domain; Region: PilZ; pfam07238 441770003150 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 441770003151 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441770003152 motif II; other site 441770003153 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 441770003154 active site 441770003155 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 441770003156 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 441770003157 aromatic chitin/cellulose binding site residues [chemical binding]; other site 441770003158 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 441770003159 aromatic chitin/cellulose binding site residues [chemical binding]; other site 441770003160 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770003161 Coenzyme A binding pocket [chemical binding]; other site 441770003162 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 441770003163 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 441770003164 Walker A/P-loop; other site 441770003165 ATP binding site [chemical binding]; other site 441770003166 Q-loop/lid; other site 441770003167 ABC transporter signature motif; other site 441770003168 Walker B; other site 441770003169 D-loop; other site 441770003170 H-loop/switch region; other site 441770003171 NIL domain; Region: NIL; pfam09383 441770003172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770003173 dimer interface [polypeptide binding]; other site 441770003174 conserved gate region; other site 441770003175 ABC-ATPase subunit interface; other site 441770003176 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 441770003177 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 441770003178 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 441770003179 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 441770003180 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 441770003181 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 441770003182 metal binding site [ion binding]; metal-binding site 441770003183 putative dimer interface [polypeptide binding]; other site 441770003184 RNase_H superfamily; Region: RNase_H_2; pfam13482 441770003185 Transcriptional regulators [Transcription]; Region: FadR; COG2186 441770003186 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770003187 DNA-binding site [nucleotide binding]; DNA binding site 441770003188 FCD domain; Region: FCD; pfam07729 441770003189 Uncharacterized conserved protein [Function unknown]; Region: COG1284 441770003190 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 441770003191 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 441770003192 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 441770003193 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 441770003194 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 441770003195 active site 441770003196 HIGH motif; other site 441770003197 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 441770003198 active site 441770003199 KMSKS motif; other site 441770003200 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 441770003201 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 441770003202 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 441770003203 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 441770003204 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 441770003205 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441770003206 Beta-Casp domain; Region: Beta-Casp; smart01027 441770003207 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 441770003208 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441770003209 Zn2+ binding site [ion binding]; other site 441770003210 Mg2+ binding site [ion binding]; other site 441770003211 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 441770003212 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 441770003213 NAD(P) binding site [chemical binding]; other site 441770003214 catalytic residues [active] 441770003215 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 441770003216 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 441770003217 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 441770003218 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 441770003219 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441770003220 MarR family; Region: MarR_2; pfam12802 441770003221 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441770003222 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 441770003223 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441770003224 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 441770003225 hypothetical protein; Provisional; Region: PRK11622 441770003226 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 441770003227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770003228 dimer interface [polypeptide binding]; other site 441770003229 conserved gate region; other site 441770003230 putative PBP binding loops; other site 441770003231 ABC-ATPase subunit interface; other site 441770003232 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 441770003233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770003234 dimer interface [polypeptide binding]; other site 441770003235 conserved gate region; other site 441770003236 putative PBP binding loops; other site 441770003237 ABC-ATPase subunit interface; other site 441770003238 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 441770003239 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 441770003240 Walker A/P-loop; other site 441770003241 ATP binding site [chemical binding]; other site 441770003242 Q-loop/lid; other site 441770003243 ABC transporter signature motif; other site 441770003244 Walker B; other site 441770003245 D-loop; other site 441770003246 H-loop/switch region; other site 441770003247 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 441770003248 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 441770003249 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 441770003250 Coenzyme A binding pocket [chemical binding]; other site 441770003251 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 441770003252 catalytic residues [active] 441770003253 maltose O-acetyltransferase; Provisional; Region: PRK10092 441770003254 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 441770003255 active site 441770003256 substrate binding site [chemical binding]; other site 441770003257 trimer interface [polypeptide binding]; other site 441770003258 CoA binding site [chemical binding]; other site 441770003259 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 441770003260 Biotin operon repressor [Transcription]; Region: BirA; COG1654 441770003261 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 441770003262 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 441770003263 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441770003264 metal-binding site [ion binding] 441770003265 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 441770003266 FOG: CBS domain [General function prediction only]; Region: COG0517 441770003267 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770003268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770003269 dimer interface [polypeptide binding]; other site 441770003270 phosphorylation site [posttranslational modification] 441770003271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770003272 ATP binding site [chemical binding]; other site 441770003273 Mg2+ binding site [ion binding]; other site 441770003274 G-X-G motif; other site 441770003275 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 441770003276 nucleophile elbow; other site 441770003277 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 441770003278 MgtE intracellular N domain; Region: MgtE_N; smart00924 441770003279 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 441770003280 Divalent cation transporter; Region: MgtE; pfam01769 441770003281 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 441770003282 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441770003283 catalytic residue [active] 441770003284 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 441770003285 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 441770003286 putative ligand binding site [chemical binding]; other site 441770003287 NAD binding site [chemical binding]; other site 441770003288 dimerization interface [polypeptide binding]; other site 441770003289 catalytic site [active] 441770003290 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 441770003291 Uncharacterized conserved protein [Function unknown]; Region: COG4198 441770003292 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 441770003293 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441770003294 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 441770003295 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 441770003296 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 441770003297 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 441770003298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 441770003299 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441770003300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 441770003301 BCCT family transporter; Region: BCCT; pfam02028 441770003302 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 441770003303 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770003304 DNA-binding site [nucleotide binding]; DNA binding site 441770003305 TrkA-C domain; Region: TrkA_C; pfam02080 441770003306 Flavin Reductases; Region: FlaRed; cl00801 441770003307 Isochorismatase family; Region: Isochorismatase; pfam00857 441770003308 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 441770003309 catalytic triad [active] 441770003310 conserved cis-peptide bond; other site 441770003311 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 441770003312 active site residue [active] 441770003313 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 441770003314 TPR repeat; Region: TPR_11; pfam13414 441770003315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441770003316 binding surface 441770003317 TPR motif; other site 441770003318 TPR repeat; Region: TPR_11; pfam13414 441770003319 TPR repeat; Region: TPR_11; pfam13414 441770003320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441770003321 binding surface 441770003322 TPR motif; other site 441770003323 TPR repeat; Region: TPR_11; pfam13414 441770003324 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441770003325 active site 441770003326 Protein of unknown function (DUF3867); Region: DUF3867; pfam12983 441770003327 Rhodanese Homology Domain; Region: RHOD; smart00450 441770003328 active site residue [active] 441770003329 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 441770003330 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 441770003331 active site residue [active] 441770003332 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 441770003333 active site residue [active] 441770003334 Domain of unknown function DUF20; Region: UPF0118; pfam01594 441770003335 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 441770003336 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 441770003337 putative metal binding site [ion binding]; other site 441770003338 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 441770003339 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 441770003340 active site 441770003341 metal-binding site [ion binding] 441770003342 nucleotide-binding site [chemical binding]; other site 441770003343 nucleotide-binding site [chemical binding]; other site 441770003344 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 441770003345 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 441770003346 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 441770003347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770003348 dimer interface [polypeptide binding]; other site 441770003349 conserved gate region; other site 441770003350 putative PBP binding loops; other site 441770003351 ABC-ATPase subunit interface; other site 441770003352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770003353 dimer interface [polypeptide binding]; other site 441770003354 conserved gate region; other site 441770003355 putative PBP binding loops; other site 441770003356 ABC-ATPase subunit interface; other site 441770003357 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 441770003358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770003359 Walker A/P-loop; other site 441770003360 ATP binding site [chemical binding]; other site 441770003361 Q-loop/lid; other site 441770003362 ABC transporter signature motif; other site 441770003363 Walker B; other site 441770003364 D-loop; other site 441770003365 H-loop/switch region; other site 441770003366 TOBE domain; Region: TOBE_2; pfam08402 441770003367 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 441770003368 Double zinc ribbon; Region: DZR; pfam12773 441770003369 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 441770003370 Double zinc ribbon; Region: DZR; pfam12773 441770003371 YARHG domain; Region: YARHG; pfam13308 441770003372 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 441770003373 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 441770003374 RNA binding site [nucleotide binding]; other site 441770003375 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 441770003376 RNA binding site [nucleotide binding]; other site 441770003377 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 441770003378 RNA binding site [nucleotide binding]; other site 441770003379 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 441770003380 RNA binding site [nucleotide binding]; other site 441770003381 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 441770003382 active site 441770003383 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 441770003384 hexamer interface [polypeptide binding]; other site 441770003385 RNA binding site [nucleotide binding]; other site 441770003386 Histidine-zinc binding site [chemical binding]; other site 441770003387 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 441770003388 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 441770003389 zinc binding site [ion binding]; other site 441770003390 putative ligand binding site [chemical binding]; other site 441770003391 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 441770003392 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 441770003393 TM-ABC transporter signature motif; other site 441770003394 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 441770003395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770003396 Walker A/P-loop; other site 441770003397 ATP binding site [chemical binding]; other site 441770003398 Q-loop/lid; other site 441770003399 ABC transporter signature motif; other site 441770003400 Walker B; other site 441770003401 D-loop; other site 441770003402 H-loop/switch region; other site 441770003403 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 441770003404 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770003405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770003406 homodimer interface [polypeptide binding]; other site 441770003407 catalytic residue [active] 441770003408 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 441770003409 EamA-like transporter family; Region: EamA; pfam00892 441770003410 EamA-like transporter family; Region: EamA; pfam00892 441770003411 putative kinase; Provisional; Region: PRK09954 441770003412 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 441770003413 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 441770003414 substrate binding site [chemical binding]; other site 441770003415 ATP binding site [chemical binding]; other site 441770003416 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 441770003417 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 441770003418 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 441770003419 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 441770003420 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 441770003421 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 441770003422 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 441770003423 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 441770003424 homodimer interface [polypeptide binding]; other site 441770003425 NADP binding site [chemical binding]; other site 441770003426 substrate binding site [chemical binding]; other site 441770003427 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 441770003428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441770003429 active site 441770003430 motif I; other site 441770003431 motif II; other site 441770003432 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 441770003433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770003434 Coenzyme A binding pocket [chemical binding]; other site 441770003435 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 441770003436 ZIP Zinc transporter; Region: Zip; pfam02535 441770003437 Predicted transcriptional regulator [Transcription]; Region: COG1959 441770003438 Transcriptional regulator; Region: Rrf2; cl17282 441770003439 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 441770003440 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 441770003441 dimer interface [polypeptide binding]; other site 441770003442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770003443 catalytic residue [active] 441770003444 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 441770003445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770003446 dimer interface [polypeptide binding]; other site 441770003447 conserved gate region; other site 441770003448 putative PBP binding loops; other site 441770003449 ABC-ATPase subunit interface; other site 441770003450 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 441770003451 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441770003452 substrate binding pocket [chemical binding]; other site 441770003453 membrane-bound complex binding site; other site 441770003454 hinge residues; other site 441770003455 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 441770003456 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 441770003457 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441770003458 catalytic residue [active] 441770003459 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 441770003460 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 441770003461 Ligand Binding Site [chemical binding]; other site 441770003462 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 441770003463 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 441770003464 Ligand Binding Site [chemical binding]; other site 441770003465 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 441770003466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770003467 active site 441770003468 phosphorylation site [posttranslational modification] 441770003469 intermolecular recognition site; other site 441770003470 LytTr DNA-binding domain; Region: LytTR; pfam04397 441770003471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770003472 ATP binding site [chemical binding]; other site 441770003473 Mg2+ binding site [ion binding]; other site 441770003474 G-X-G motif; other site 441770003475 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441770003476 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 441770003477 Walker A/P-loop; other site 441770003478 ATP binding site [chemical binding]; other site 441770003479 Q-loop/lid; other site 441770003480 ABC transporter signature motif; other site 441770003481 Walker B; other site 441770003482 D-loop; other site 441770003483 H-loop/switch region; other site 441770003484 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 441770003485 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 441770003486 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 441770003487 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 441770003488 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 441770003489 active site 441770003490 catalytic site [active] 441770003491 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 441770003492 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 441770003493 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 441770003494 dimer interface [polypeptide binding]; other site 441770003495 PYR/PP interface [polypeptide binding]; other site 441770003496 TPP binding site [chemical binding]; other site 441770003497 substrate binding site [chemical binding]; other site 441770003498 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 441770003499 Domain of unknown function; Region: EKR; pfam10371 441770003500 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 441770003501 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 441770003502 TPP-binding site [chemical binding]; other site 441770003503 dimer interface [polypeptide binding]; other site 441770003504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441770003505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441770003506 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 441770003507 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 441770003508 Uncharacterized conserved protein [Function unknown]; Region: COG0397 441770003509 hypothetical protein; Validated; Region: PRK00029 441770003510 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 441770003511 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 441770003512 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 441770003513 Helix-turn-helix domain; Region: HTH_18; pfam12833 441770003514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770003515 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 441770003516 MFS/sugar transport protein; Region: MFS_2; pfam13347 441770003517 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 441770003518 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 441770003519 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 441770003520 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 441770003521 nucleotide binding site [chemical binding]; other site 441770003522 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 441770003523 beta-galactosidase; Region: BGL; TIGR03356 441770003524 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; cl03185 441770003525 Beta-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. Beta-amylase has, in addition to its C-terminal CBM20 domain, an N-terminal catalytic domain belonging to glycosyl hydrolase family 14, which hydrolyzes the alpha-1; Region: CBM20_beta_amylase; cd05809 441770003526 starch-binding site 2 [chemical binding]; other site 441770003527 starch-binding site 1 [chemical binding]; other site 441770003528 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 441770003529 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 441770003530 active site 441770003531 HIGH motif; other site 441770003532 dimer interface [polypeptide binding]; other site 441770003533 KMSKS motif; other site 441770003534 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441770003535 RNA binding surface [nucleotide binding]; other site 441770003536 Predicted transcriptional regulators [Transcription]; Region: COG1725 441770003537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770003538 DNA-binding site [nucleotide binding]; DNA binding site 441770003539 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441770003540 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441770003541 Walker A/P-loop; other site 441770003542 ATP binding site [chemical binding]; other site 441770003543 Q-loop/lid; other site 441770003544 ABC transporter signature motif; other site 441770003545 Walker B; other site 441770003546 D-loop; other site 441770003547 H-loop/switch region; other site 441770003548 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441770003549 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 441770003550 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441770003551 Bacterial SH3 domain; Region: SH3_3; pfam08239 441770003552 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 441770003553 active site 441770003554 PAS domain S-box; Region: sensory_box; TIGR00229 441770003555 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441770003556 putative active site [active] 441770003557 heme pocket [chemical binding]; other site 441770003558 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441770003559 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441770003560 metal binding site [ion binding]; metal-binding site 441770003561 active site 441770003562 I-site; other site 441770003563 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 441770003564 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 441770003565 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 441770003566 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 441770003567 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 441770003568 Uncharacterized conserved protein [Function unknown]; Region: COG5663 441770003569 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 441770003570 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 441770003571 active site 441770003572 dimer interface [polypeptide binding]; other site 441770003573 Yip1 domain; Region: Yip1; pfam04893 441770003574 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 441770003575 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 441770003576 FtsX-like permease family; Region: FtsX; pfam02687 441770003577 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 441770003578 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441770003579 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441770003580 Walker A/P-loop; other site 441770003581 ATP binding site [chemical binding]; other site 441770003582 Q-loop/lid; other site 441770003583 ABC transporter signature motif; other site 441770003584 Walker B; other site 441770003585 D-loop; other site 441770003586 H-loop/switch region; other site 441770003587 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 441770003588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770003589 dimer interface [polypeptide binding]; other site 441770003590 conserved gate region; other site 441770003591 putative PBP binding loops; other site 441770003592 ABC-ATPase subunit interface; other site 441770003593 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 441770003594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770003595 dimer interface [polypeptide binding]; other site 441770003596 conserved gate region; other site 441770003597 putative PBP binding loops; other site 441770003598 ABC-ATPase subunit interface; other site 441770003599 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 441770003600 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 441770003601 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 441770003602 CotJB protein; Region: CotJB; pfam12652 441770003603 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 441770003604 dimanganese center [ion binding]; other site 441770003605 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 441770003606 Tubby C 2; Region: Tub_2; cl02043 441770003607 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 441770003608 trimer interface [polypeptide binding]; other site 441770003609 active site 441770003610 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 441770003611 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 441770003612 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770003613 non-specific DNA binding site [nucleotide binding]; other site 441770003614 salt bridge; other site 441770003615 sequence-specific DNA binding site [nucleotide binding]; other site 441770003616 Cupin domain; Region: Cupin_2; pfam07883 441770003617 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 441770003618 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 441770003619 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441770003620 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441770003621 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 441770003622 amino acid carrier protein; Region: agcS; TIGR00835 441770003623 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770003624 non-specific DNA binding site [nucleotide binding]; other site 441770003625 salt bridge; other site 441770003626 sequence-specific DNA binding site [nucleotide binding]; other site 441770003627 Helix-turn-helix domain; Region: HTH_17; pfam12728 441770003628 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 441770003629 catalytic residues [active] 441770003630 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 441770003631 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 441770003632 tetrameric interface [polypeptide binding]; other site 441770003633 activator binding site; other site 441770003634 NADP binding site [chemical binding]; other site 441770003635 substrate binding site [chemical binding]; other site 441770003636 catalytic residues [active] 441770003637 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 441770003638 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 441770003639 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 441770003640 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 441770003641 selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918 441770003642 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 441770003643 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 441770003644 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441770003645 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 441770003646 catalytic residues [active] 441770003647 glycine/sarcosine/betaine reductase complex protein A; Reviewed; Region: PRK13265 441770003648 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 441770003649 dimer interface [polypeptide binding]; other site 441770003650 active site 441770003651 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 441770003652 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 441770003653 active site 441770003654 DNA binding site [nucleotide binding] 441770003655 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 441770003656 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 441770003657 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 441770003658 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 441770003659 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 441770003660 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 441770003661 intersubunit interface [polypeptide binding]; other site 441770003662 active site 441770003663 Zn2+ binding site [ion binding]; other site 441770003664 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 441770003665 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 441770003666 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 441770003667 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 441770003668 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 441770003669 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 441770003670 Predicted membrane protein [Function unknown]; Region: COG2323 441770003671 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 441770003672 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 441770003673 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 441770003674 A short protein domain of unknown function; Region: IDEAL; smart00914 441770003675 PQ loop repeat; Region: PQ-loop; cl17546 441770003676 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 441770003677 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441770003678 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441770003679 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 441770003680 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 441770003681 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 441770003682 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441770003683 catalytic loop [active] 441770003684 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 441770003685 iron binding site [ion binding]; other site 441770003686 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 441770003687 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 441770003688 nucleoside/Zn binding site; other site 441770003689 dimer interface [polypeptide binding]; other site 441770003690 catalytic motif [active] 441770003691 DNA topoisomerase III; Provisional; Region: PRK07726 441770003692 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 441770003693 active site 441770003694 putative interdomain interaction site [polypeptide binding]; other site 441770003695 putative metal-binding site [ion binding]; other site 441770003696 putative nucleotide binding site [chemical binding]; other site 441770003697 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 441770003698 domain I; other site 441770003699 DNA binding groove [nucleotide binding] 441770003700 phosphate binding site [ion binding]; other site 441770003701 domain II; other site 441770003702 domain III; other site 441770003703 nucleotide binding site [chemical binding]; other site 441770003704 catalytic site [active] 441770003705 domain IV; other site 441770003706 Predicted membrane protein [Function unknown]; Region: COG1971 441770003707 Domain of unknown function DUF; Region: DUF204; pfam02659 441770003708 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 441770003709 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 441770003710 active site 441770003711 intersubunit interactions; other site 441770003712 catalytic residue [active] 441770003713 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 441770003714 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441770003715 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 441770003716 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 441770003717 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 441770003718 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441770003719 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441770003720 metal binding site [ion binding]; metal-binding site 441770003721 active site 441770003722 I-site; other site 441770003723 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 441770003724 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 441770003725 NodB motif; other site 441770003726 putative active site [active] 441770003727 putative catalytic site [active] 441770003728 putative Zn binding site [ion binding]; other site 441770003729 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 441770003730 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 441770003731 DXD motif; other site 441770003732 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 441770003733 Probable zinc-binding domain; Region: zf-trcl; pfam13451 441770003734 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 441770003735 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 441770003736 putative homodimer interface [polypeptide binding]; other site 441770003737 putative homotetramer interface [polypeptide binding]; other site 441770003738 putative allosteric switch controlling residues; other site 441770003739 putative metal binding site [ion binding]; other site 441770003740 putative homodimer-homodimer interface [polypeptide binding]; other site 441770003741 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 441770003742 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441770003743 metal-binding site [ion binding] 441770003744 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 441770003745 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441770003746 metal-binding site [ion binding] 441770003747 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441770003748 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441770003749 motif II; other site 441770003750 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441770003751 metal-binding site [ion binding] 441770003752 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 441770003753 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441770003754 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 441770003755 Soluble P-type ATPase [General function prediction only]; Region: COG4087 441770003756 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 441770003757 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441770003758 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441770003759 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 441770003760 Walker A/P-loop; other site 441770003761 ATP binding site [chemical binding]; other site 441770003762 Q-loop/lid; other site 441770003763 ABC transporter signature motif; other site 441770003764 Walker B; other site 441770003765 D-loop; other site 441770003766 H-loop/switch region; other site 441770003767 CAAX protease self-immunity; Region: Abi; pfam02517 441770003768 Uncharacterized conserved protein [Function unknown]; Region: COG1433 441770003769 EDD domain protein, DegV family; Region: DegV; TIGR00762 441770003770 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 441770003771 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 441770003772 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 441770003773 nucleotide binding site/active site [active] 441770003774 HIT family signature motif; other site 441770003775 catalytic residue [active] 441770003776 Membrane protein of unknown function; Region: DUF360; pfam04020 441770003777 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 441770003778 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 441770003779 YibE/F-like protein; Region: YibE_F; pfam07907 441770003780 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 441770003781 TrkA-N domain; Region: TrkA_N; pfam02254 441770003782 TrkA-C domain; Region: TrkA_C; pfam02080 441770003783 TrkA-N domain; Region: TrkA_N; pfam02254 441770003784 TrkA-C domain; Region: TrkA_C; pfam02080 441770003785 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 441770003786 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 441770003787 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 441770003788 Part of AAA domain; Region: AAA_19; pfam13245 441770003789 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 441770003790 active site 441770003791 catalytic site [active] 441770003792 substrate binding site [chemical binding]; other site 441770003793 Family description; Region: UvrD_C_2; pfam13538 441770003794 Predicted membrane protein [General function prediction only]; Region: COG4194 441770003795 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 441770003796 Predicted transcriptional regulators [Transcription]; Region: COG1725 441770003797 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770003798 DNA-binding site [nucleotide binding]; DNA binding site 441770003799 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441770003800 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441770003801 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 441770003802 Rubrerythrin [Energy production and conversion]; Region: COG1592 441770003803 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 441770003804 binuclear metal center [ion binding]; other site 441770003805 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 441770003806 iron binding site [ion binding]; other site 441770003807 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441770003808 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441770003809 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441770003810 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441770003811 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 441770003812 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441770003813 active site turn [active] 441770003814 phosphorylation site [posttranslational modification] 441770003815 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 441770003816 HPr interaction site; other site 441770003817 glycerol kinase (GK) interaction site [polypeptide binding]; other site 441770003818 active site 441770003819 phosphorylation site [posttranslational modification] 441770003820 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 441770003821 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 441770003822 catalytic residue [active] 441770003823 putative FPP diphosphate binding site; other site 441770003824 putative FPP binding hydrophobic cleft; other site 441770003825 dimer interface [polypeptide binding]; other site 441770003826 putative IPP diphosphate binding site; other site 441770003827 Rrf2 family protein; Region: rrf2_super; TIGR00738 441770003828 Transcriptional regulator; Region: Rrf2; pfam02082 441770003829 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 441770003830 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 441770003831 ACS interaction site; other site 441770003832 CODH interaction site; other site 441770003833 metal cluster binding site [ion binding]; other site 441770003834 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 441770003835 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 441770003836 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 441770003837 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441770003838 EamA-like transporter family; Region: EamA; pfam00892 441770003839 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 441770003840 EamA-like transporter family; Region: EamA; pfam00892 441770003841 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441770003842 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441770003843 ligand binding site [chemical binding]; other site 441770003844 flexible hinge region; other site 441770003845 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 441770003846 putative switch regulator; other site 441770003847 non-specific DNA interactions [nucleotide binding]; other site 441770003848 DNA binding site [nucleotide binding] 441770003849 sequence specific DNA binding site [nucleotide binding]; other site 441770003850 putative cAMP binding site [chemical binding]; other site 441770003851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441770003852 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441770003853 putative substrate translocation pore; other site 441770003854 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 441770003855 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 441770003856 putative binding site residues; other site 441770003857 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 441770003858 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441770003859 ABC-ATPase subunit interface; other site 441770003860 dimer interface [polypeptide binding]; other site 441770003861 putative PBP binding regions; other site 441770003862 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 441770003863 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 441770003864 Walker A/P-loop; other site 441770003865 ATP binding site [chemical binding]; other site 441770003866 Q-loop/lid; other site 441770003867 ABC transporter signature motif; other site 441770003868 Walker B; other site 441770003869 D-loop; other site 441770003870 H-loop/switch region; other site 441770003871 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 441770003872 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 441770003873 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 441770003874 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 441770003875 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 441770003876 putative active site [active] 441770003877 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 441770003878 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 441770003879 putative active site [active] 441770003880 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 441770003881 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 441770003882 active site turn [active] 441770003883 phosphorylation site [posttranslational modification] 441770003884 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441770003885 Uncharacterized conserved protein [Function unknown]; Region: COG3589 441770003886 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 441770003887 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 441770003888 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 441770003889 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441770003890 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 441770003891 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441770003892 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 441770003893 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 441770003894 HAMP domain; Region: HAMP; pfam00672 441770003895 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441770003896 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770003897 dimer interface [polypeptide binding]; other site 441770003898 putative CheW interface [polypeptide binding]; other site 441770003899 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 441770003900 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 441770003901 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 441770003902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770003903 dimer interface [polypeptide binding]; other site 441770003904 conserved gate region; other site 441770003905 putative PBP binding loops; other site 441770003906 ABC-ATPase subunit interface; other site 441770003907 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 441770003908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770003909 dimer interface [polypeptide binding]; other site 441770003910 conserved gate region; other site 441770003911 putative PBP binding loops; other site 441770003912 ABC-ATPase subunit interface; other site 441770003913 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441770003914 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 441770003915 Walker A/P-loop; other site 441770003916 ATP binding site [chemical binding]; other site 441770003917 Q-loop/lid; other site 441770003918 ABC transporter signature motif; other site 441770003919 Walker B; other site 441770003920 D-loop; other site 441770003921 H-loop/switch region; other site 441770003922 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 441770003923 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441770003924 Walker A/P-loop; other site 441770003925 ATP binding site [chemical binding]; other site 441770003926 Q-loop/lid; other site 441770003927 ABC transporter signature motif; other site 441770003928 Walker B; other site 441770003929 D-loop; other site 441770003930 H-loop/switch region; other site 441770003931 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 441770003932 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441770003933 ABC-ATPase subunit interface; other site 441770003934 dimer interface [polypeptide binding]; other site 441770003935 putative PBP binding regions; other site 441770003936 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 441770003937 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 441770003938 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 441770003939 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 441770003940 metal binding site [ion binding]; metal-binding site 441770003941 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 441770003942 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441770003943 nucleotide binding region [chemical binding]; other site 441770003944 ATP-binding site [chemical binding]; other site 441770003945 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 441770003946 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441770003947 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441770003948 metal binding site [ion binding]; metal-binding site 441770003949 active site 441770003950 I-site; other site 441770003951 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 441770003952 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 441770003953 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 441770003954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 441770003955 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441770003956 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770003957 Walker A/P-loop; other site 441770003958 ATP binding site [chemical binding]; other site 441770003959 Q-loop/lid; other site 441770003960 ABC transporter signature motif; other site 441770003961 Walker B; other site 441770003962 D-loop; other site 441770003963 H-loop/switch region; other site 441770003964 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 441770003965 metal binding site 2 [ion binding]; metal-binding site 441770003966 putative DNA binding helix; other site 441770003967 metal binding site 1 [ion binding]; metal-binding site 441770003968 dimer interface [polypeptide binding]; other site 441770003969 structural Zn2+ binding site [ion binding]; other site 441770003970 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 441770003971 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 441770003972 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441770003973 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 441770003974 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441770003975 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 441770003976 putative active site [active] 441770003977 Zn binding site [ion binding]; other site 441770003978 ribonuclease Z; Region: RNase_Z; TIGR02651 441770003979 L-type amino acid transporter; Region: 2A0308; TIGR00911 441770003980 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 441770003981 pentamer interface [polypeptide binding]; other site 441770003982 dodecaamer interface [polypeptide binding]; other site 441770003983 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 441770003984 Histidine kinase; Region: HisKA_3; pfam07730 441770003985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770003986 ATP binding site [chemical binding]; other site 441770003987 Mg2+ binding site [ion binding]; other site 441770003988 G-X-G motif; other site 441770003989 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 441770003990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770003991 active site 441770003992 phosphorylation site [posttranslational modification] 441770003993 intermolecular recognition site; other site 441770003994 dimerization interface [polypeptide binding]; other site 441770003995 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441770003996 DNA binding residues [nucleotide binding] 441770003997 dimerization interface [polypeptide binding]; other site 441770003998 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441770003999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770004000 Walker A/P-loop; other site 441770004001 ATP binding site [chemical binding]; other site 441770004002 Q-loop/lid; other site 441770004003 ABC transporter signature motif; other site 441770004004 Walker B; other site 441770004005 D-loop; other site 441770004006 H-loop/switch region; other site 441770004007 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 441770004008 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 441770004009 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 441770004010 FMN binding site [chemical binding]; other site 441770004011 dimer interface [polypeptide binding]; other site 441770004012 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 441770004013 DNA-binding site [nucleotide binding]; DNA binding site 441770004014 RNA-binding motif; other site 441770004015 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 441770004016 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 441770004017 metal binding site [ion binding]; metal-binding site 441770004018 dimer interface [polypeptide binding]; other site 441770004019 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441770004020 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 441770004021 dimer interface [polypeptide binding]; other site 441770004022 pyridoxal binding site [chemical binding]; other site 441770004023 ATP binding site [chemical binding]; other site 441770004024 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 441770004025 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441770004026 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441770004027 Walker A/P-loop; other site 441770004028 ATP binding site [chemical binding]; other site 441770004029 Q-loop/lid; other site 441770004030 ABC transporter signature motif; other site 441770004031 Walker B; other site 441770004032 D-loop; other site 441770004033 H-loop/switch region; other site 441770004034 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 441770004035 FtsX-like permease family; Region: FtsX; pfam02687 441770004036 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770004037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770004038 active site 441770004039 phosphorylation site [posttranslational modification] 441770004040 intermolecular recognition site; other site 441770004041 dimerization interface [polypeptide binding]; other site 441770004042 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770004043 DNA binding site [nucleotide binding] 441770004044 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770004045 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 441770004046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770004047 ATP binding site [chemical binding]; other site 441770004048 Mg2+ binding site [ion binding]; other site 441770004049 G-X-G motif; other site 441770004050 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441770004051 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441770004052 Walker A/P-loop; other site 441770004053 ATP binding site [chemical binding]; other site 441770004054 Q-loop/lid; other site 441770004055 ABC transporter signature motif; other site 441770004056 Walker B; other site 441770004057 D-loop; other site 441770004058 H-loop/switch region; other site 441770004059 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 441770004060 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 441770004061 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 441770004062 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 441770004063 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770004064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770004065 homodimer interface [polypeptide binding]; other site 441770004066 catalytic residue [active] 441770004067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770004068 dimer interface [polypeptide binding]; other site 441770004069 conserved gate region; other site 441770004070 putative PBP binding loops; other site 441770004071 ABC-ATPase subunit interface; other site 441770004072 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 441770004073 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 441770004074 Walker A/P-loop; other site 441770004075 ATP binding site [chemical binding]; other site 441770004076 Q-loop/lid; other site 441770004077 ABC transporter signature motif; other site 441770004078 Walker B; other site 441770004079 D-loop; other site 441770004080 H-loop/switch region; other site 441770004081 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770004082 non-specific DNA binding site [nucleotide binding]; other site 441770004083 salt bridge; other site 441770004084 sequence-specific DNA binding site [nucleotide binding]; other site 441770004085 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 441770004086 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 441770004087 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 441770004088 putative active site [active] 441770004089 putative CoA binding site [chemical binding]; other site 441770004090 nudix motif; other site 441770004091 metal binding site [ion binding]; metal-binding site 441770004092 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 441770004093 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 441770004094 dimer interface [polypeptide binding]; other site 441770004095 active site 441770004096 metal binding site [ion binding]; metal-binding site 441770004097 Predicted membrane protein [Function unknown]; Region: COG1288 441770004098 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 441770004099 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 441770004100 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 441770004101 active site 441770004102 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441770004103 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 441770004104 substrate binding pocket [chemical binding]; other site 441770004105 membrane-bound complex binding site; other site 441770004106 hinge residues; other site 441770004107 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 441770004108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770004109 dimer interface [polypeptide binding]; other site 441770004110 conserved gate region; other site 441770004111 putative PBP binding loops; other site 441770004112 ABC-ATPase subunit interface; other site 441770004113 Protein of unknown function (DUF523); Region: DUF523; cl00733 441770004114 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 441770004115 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441770004116 ATP binding site [chemical binding]; other site 441770004117 Family description; Region: UvrD_C_2; pfam13538 441770004118 Phage tail protein; Region: Sipho_tail; cl17486 441770004119 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 441770004120 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770004121 Coenzyme A binding pocket [chemical binding]; other site 441770004122 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 441770004123 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 441770004124 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 441770004125 active site 441770004126 metal binding site [ion binding]; metal-binding site 441770004127 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441770004128 Coat F domain; Region: Coat_F; pfam07875 441770004129 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 441770004130 Family description; Region: UvrD_C_2; pfam13538 441770004131 cell division protein FtsA; Region: ftsA; TIGR01174 441770004132 Cell division protein FtsA; Region: FtsA; smart00842 441770004133 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 441770004134 Cell division protein FtsA; Region: FtsA; pfam14450 441770004135 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 441770004136 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 441770004137 metal binding site [ion binding]; metal-binding site 441770004138 dimer interface [polypeptide binding]; other site 441770004139 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 441770004140 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 441770004141 active site 441770004142 metal binding site [ion binding]; metal-binding site 441770004143 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 441770004144 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441770004145 RNA binding surface [nucleotide binding]; other site 441770004146 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 441770004147 active site 441770004148 stage V sporulation protein B; Region: spore_V_B; TIGR02900 441770004149 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 441770004150 stage V sporulation protein B; Region: spore_V_B; TIGR02900 441770004151 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 441770004152 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 441770004153 diiron binding motif [ion binding]; other site 441770004154 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 441770004155 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 441770004156 putative active site [active] 441770004157 metal binding site [ion binding]; metal-binding site 441770004158 AAA domain; Region: AAA_32; pfam13654 441770004159 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 441770004160 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 441770004161 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 441770004162 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 441770004163 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 441770004164 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 441770004165 active site 441770004166 Zn binding site [ion binding]; other site 441770004167 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 441770004168 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 441770004169 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 441770004170 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 441770004171 active site 441770004172 Zn binding site [ion binding]; other site 441770004173 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 441770004174 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 441770004175 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 441770004176 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 441770004177 active site 441770004178 Zn binding site [ion binding]; other site 441770004179 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 441770004180 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 441770004181 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 441770004182 active site 441770004183 Zn binding site [ion binding]; other site 441770004184 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 441770004185 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 441770004186 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 441770004187 active site 441770004188 Zn binding site [ion binding]; other site 441770004189 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 441770004190 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 441770004191 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 441770004192 active site 441770004193 Zn binding site [ion binding]; other site 441770004194 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 441770004195 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 441770004196 dimerization interface [polypeptide binding]; other site 441770004197 active site 441770004198 L-aspartate oxidase; Provisional; Region: PRK06175 441770004199 FAD binding domain; Region: FAD_binding_2; pfam00890 441770004200 Quinolinate synthetase A protein; Region: NadA; pfam02445 441770004201 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 441770004202 metal binding site [ion binding]; metal-binding site 441770004203 Haemolysin-III related; Region: HlyIII; cl03831 441770004204 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 441770004205 GTP-binding protein YchF; Reviewed; Region: PRK09601 441770004206 YchF GTPase; Region: YchF; cd01900 441770004207 G1 box; other site 441770004208 GTP/Mg2+ binding site [chemical binding]; other site 441770004209 Switch I region; other site 441770004210 G2 box; other site 441770004211 Switch II region; other site 441770004212 G3 box; other site 441770004213 G4 box; other site 441770004214 G5 box; other site 441770004215 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 441770004216 cell division protein MraZ; Reviewed; Region: PRK00326 441770004217 MraZ protein; Region: MraZ; pfam02381 441770004218 MraZ protein; Region: MraZ; pfam02381 441770004219 MraW methylase family; Region: Methyltransf_5; pfam01795 441770004220 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 441770004221 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 441770004222 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 441770004223 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 441770004224 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 441770004225 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 441770004226 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 441770004227 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 441770004228 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441770004229 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441770004230 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 441770004231 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 441770004232 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441770004233 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441770004234 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 441770004235 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 441770004236 Mg++ binding site [ion binding]; other site 441770004237 putative catalytic motif [active] 441770004238 putative substrate binding site [chemical binding]; other site 441770004239 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 441770004240 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 441770004241 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 441770004242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 441770004243 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 441770004244 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 441770004245 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 441770004246 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 441770004247 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441770004248 catalytic residue [active] 441770004249 Protein of unknown function (DUF552); Region: DUF552; cl00775 441770004250 YGGT family; Region: YGGT; pfam02325 441770004251 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 441770004252 DivIVA protein; Region: DivIVA; pfam05103 441770004253 DivIVA domain; Region: DivI1A_domain; TIGR03544 441770004254 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 441770004255 active site 441770004256 dimer interface [polypeptide binding]; other site 441770004257 metal binding site [ion binding]; metal-binding site 441770004258 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 441770004259 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 441770004260 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13398 441770004261 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 441770004262 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 441770004263 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 441770004264 hinge; other site 441770004265 active site 441770004266 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 441770004267 lipoprotein signal peptidase; Provisional; Region: PRK14791 441770004268 lipoprotein signal peptidase; Provisional; Region: PRK14787 441770004269 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 441770004270 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441770004271 RNA binding surface [nucleotide binding]; other site 441770004272 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 441770004273 active site 441770004274 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 441770004275 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441770004276 active site 441770004277 uracil transporter; Provisional; Region: PRK10720 441770004278 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 441770004279 active site 441770004280 putative catalytic site [active] 441770004281 phosphate binding site A [ion binding]; other site 441770004282 DNA binding site [nucleotide binding] 441770004283 metal binding site A [ion binding]; metal-binding site 441770004284 putative AP binding site [nucleotide binding]; other site 441770004285 putative metal binding site B [ion binding]; other site 441770004286 phosphate binding site B [ion binding]; other site 441770004287 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 441770004288 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 441770004289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441770004290 Carbonic anhydrase; Region: Pro_CA; smart00947 441770004291 active site clefts [active] 441770004292 zinc binding site [ion binding]; other site 441770004293 dimer interface [polypeptide binding]; other site 441770004294 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 441770004295 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 441770004296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770004297 dimer interface [polypeptide binding]; other site 441770004298 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 441770004299 conserved gate region; other site 441770004300 putative PBP binding loops; other site 441770004301 ABC-ATPase subunit interface; other site 441770004302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770004303 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 441770004304 Walker A/P-loop; other site 441770004305 ATP binding site [chemical binding]; other site 441770004306 Q-loop/lid; other site 441770004307 ABC transporter signature motif; other site 441770004308 Walker B; other site 441770004309 D-loop; other site 441770004310 H-loop/switch region; other site 441770004311 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 441770004312 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 441770004313 active site 441770004314 nucleophile elbow; other site 441770004315 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 441770004316 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 441770004317 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 441770004318 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 441770004319 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 441770004320 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441770004321 Uroporphyrinogen decarboxylase (URO-D); Region: URO-D; pfam01208 441770004322 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 441770004323 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 441770004324 B12 binding site [chemical binding]; other site 441770004325 cobalt ligand [ion binding]; other site 441770004326 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 441770004327 MtaA_CmuA_like family. MtaA/CmuA, also MtsA, or methyltransferase 2 (MT2) MT2-A and MT2-M isozymes, are methylcobamide:Coenzyme M methyltransferases, which play a role in metabolic pathways of methane formation from various substrates, such as methylated...; Region: Mta_CmuA_like; cd03307 441770004328 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 441770004329 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 441770004330 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 441770004331 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 441770004332 Walker A/P-loop; other site 441770004333 ATP binding site [chemical binding]; other site 441770004334 Q-loop/lid; other site 441770004335 ABC transporter signature motif; other site 441770004336 Walker B; other site 441770004337 D-loop; other site 441770004338 H-loop/switch region; other site 441770004339 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 441770004340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770004341 dimer interface [polypeptide binding]; other site 441770004342 conserved gate region; other site 441770004343 ABC-ATPase subunit interface; other site 441770004344 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 441770004345 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 441770004346 MORN repeat; Region: MORN; cl14787 441770004347 MORN repeat; Region: MORN; cl14787 441770004348 MORN repeat; Region: MORN; cl14787 441770004349 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 441770004350 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 441770004351 active site 441770004352 FMN binding site [chemical binding]; other site 441770004353 substrate binding site [chemical binding]; other site 441770004354 putative catalytic residue [active] 441770004355 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 441770004356 dimer interface [polypeptide binding]; other site 441770004357 active site 441770004358 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 441770004359 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 441770004360 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 441770004361 [2Fe-2S] cluster binding site [ion binding]; other site 441770004362 DNA topoisomerase III; Provisional; Region: PRK07726 441770004363 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 441770004364 active site 441770004365 putative interdomain interaction site [polypeptide binding]; other site 441770004366 putative metal-binding site [ion binding]; other site 441770004367 putative nucleotide binding site [chemical binding]; other site 441770004368 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 441770004369 domain I; other site 441770004370 DNA binding groove [nucleotide binding] 441770004371 phosphate binding site [ion binding]; other site 441770004372 domain II; other site 441770004373 domain III; other site 441770004374 nucleotide binding site [chemical binding]; other site 441770004375 catalytic site [active] 441770004376 domain IV; other site 441770004377 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 441770004378 Walker A/P-loop; other site 441770004379 ATP binding site [chemical binding]; other site 441770004380 Q-loop/lid; other site 441770004381 ABC transporter signature motif; other site 441770004382 Walker B; other site 441770004383 D-loop; other site 441770004384 H-loop/switch region; other site 441770004385 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 441770004386 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 441770004387 active site 441770004388 catalytic tetrad [active] 441770004389 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 441770004390 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 441770004391 putative deacylase active site [active] 441770004392 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441770004393 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441770004394 Walker A/P-loop; other site 441770004395 ATP binding site [chemical binding]; other site 441770004396 Q-loop/lid; other site 441770004397 ABC transporter signature motif; other site 441770004398 Walker B; other site 441770004399 D-loop; other site 441770004400 H-loop/switch region; other site 441770004401 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441770004402 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441770004403 Protein of unknown function (DUF523); Region: DUF523; pfam04463 441770004404 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 441770004405 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 441770004406 Walker A/P-loop; other site 441770004407 ATP binding site [chemical binding]; other site 441770004408 Q-loop/lid; other site 441770004409 ABC transporter signature motif; other site 441770004410 Walker B; other site 441770004411 D-loop; other site 441770004412 H-loop/switch region; other site 441770004413 TOBE domain; Region: TOBE; pfam03459 441770004414 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 441770004415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770004416 dimer interface [polypeptide binding]; other site 441770004417 conserved gate region; other site 441770004418 putative PBP binding loops; other site 441770004419 ABC-ATPase subunit interface; other site 441770004420 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 441770004421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770004422 dimer interface [polypeptide binding]; other site 441770004423 conserved gate region; other site 441770004424 putative PBP binding loops; other site 441770004425 ABC-ATPase subunit interface; other site 441770004426 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 441770004427 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 441770004428 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 441770004429 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 441770004430 NAD binding site [chemical binding]; other site 441770004431 dimer interface [polypeptide binding]; other site 441770004432 substrate binding site [chemical binding]; other site 441770004433 tetramer (dimer of dimers) interface [polypeptide binding]; other site 441770004434 Transcriptional regulators [Transcription]; Region: FadR; COG2186 441770004435 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770004436 DNA-binding site [nucleotide binding]; DNA binding site 441770004437 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 441770004438 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 441770004439 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 441770004440 gating phenylalanine in ion channel; other site 441770004441 PAS domain S-box; Region: sensory_box; TIGR00229 441770004442 PAS domain; Region: PAS; smart00091 441770004443 putative active site [active] 441770004444 heme pocket [chemical binding]; other site 441770004445 PAS domain S-box; Region: sensory_box; TIGR00229 441770004446 PAS domain; Region: PAS_8; pfam13188 441770004447 putative active site [active] 441770004448 heme pocket [chemical binding]; other site 441770004449 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441770004450 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441770004451 metal binding site [ion binding]; metal-binding site 441770004452 active site 441770004453 I-site; other site 441770004454 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 441770004455 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441770004456 Zn2+ binding site [ion binding]; other site 441770004457 Mg2+ binding site [ion binding]; other site 441770004458 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 441770004459 dimerization interface [polypeptide binding]; other site 441770004460 Cache domain; Region: Cache_1; pfam02743 441770004461 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441770004462 dimerization interface [polypeptide binding]; other site 441770004463 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441770004464 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770004465 dimer interface [polypeptide binding]; other site 441770004466 putative CheW interface [polypeptide binding]; other site 441770004467 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441770004468 MarR family; Region: MarR_2; pfam12802 441770004469 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 441770004470 Predicted transcriptional regulators [Transcription]; Region: COG1733 441770004471 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 441770004472 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 441770004473 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 441770004474 active site 441770004475 metal binding site [ion binding]; metal-binding site 441770004476 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 441770004477 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 441770004478 DNA binding site [nucleotide binding] 441770004479 active site 441770004480 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 441770004481 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770004482 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441770004483 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770004484 hypothetical protein; Provisional; Region: PRK02399 441770004485 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 441770004486 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 441770004487 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441770004488 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770004489 non-specific DNA binding site [nucleotide binding]; other site 441770004490 salt bridge; other site 441770004491 sequence-specific DNA binding site [nucleotide binding]; other site 441770004492 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 441770004493 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 441770004494 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 441770004495 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 441770004496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441770004497 putative substrate translocation pore; other site 441770004498 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 441770004499 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 441770004500 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 441770004501 HDOD domain; Region: HDOD; pfam08668 441770004502 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441770004503 Zn2+ binding site [ion binding]; other site 441770004504 Mg2+ binding site [ion binding]; other site 441770004505 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 441770004506 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 441770004507 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441770004508 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 441770004509 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 441770004510 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 441770004511 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 441770004512 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 441770004513 active site 441770004514 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 441770004515 Chloramphenicol acetyltransferase; Region: CAT; smart01059 441770004516 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 441770004517 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441770004518 ligand binding site [chemical binding]; other site 441770004519 flexible hinge region; other site 441770004520 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 441770004521 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441770004522 dimerization interface [polypeptide binding]; other site 441770004523 DNA binding residues [nucleotide binding] 441770004524 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 441770004525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 441770004526 Predicted transcriptional regulator [Transcription]; Region: COG2378 441770004527 HTH domain; Region: HTH_11; pfam08279 441770004528 WYL domain; Region: WYL; pfam13280 441770004529 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 441770004530 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 441770004531 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 441770004532 active site 441770004533 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 441770004534 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770004535 FeS/SAM binding site; other site 441770004536 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 441770004537 active site 441770004538 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 441770004539 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 441770004540 Ligand Binding Site [chemical binding]; other site 441770004541 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441770004542 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770004543 dimer interface [polypeptide binding]; other site 441770004544 putative CheW interface [polypeptide binding]; other site 441770004545 Protein of unknown function (DUF975); Region: DUF975; cl10504 441770004546 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 441770004547 MarR family; Region: MarR_2; pfam12802 441770004548 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 441770004549 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 441770004550 intersubunit interface [polypeptide binding]; other site 441770004551 active site 441770004552 catalytic residue [active] 441770004553 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 441770004554 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 441770004555 substrate binding site [chemical binding]; other site 441770004556 dimer interface [polypeptide binding]; other site 441770004557 ATP binding site [chemical binding]; other site 441770004558 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 441770004559 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 441770004560 dimer interface [polypeptide binding]; other site 441770004561 motif 1; other site 441770004562 active site 441770004563 motif 2; other site 441770004564 motif 3; other site 441770004565 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 441770004566 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 441770004567 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 441770004568 histidinol dehydrogenase; Region: hisD; TIGR00069 441770004569 NAD binding site [chemical binding]; other site 441770004570 dimerization interface [polypeptide binding]; other site 441770004571 product binding site; other site 441770004572 substrate binding site [chemical binding]; other site 441770004573 zinc binding site [ion binding]; other site 441770004574 catalytic residues [active] 441770004575 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 441770004576 putative active site pocket [active] 441770004577 4-fold oligomerization interface [polypeptide binding]; other site 441770004578 metal binding residues [ion binding]; metal-binding site 441770004579 3-fold/trimer interface [polypeptide binding]; other site 441770004580 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 441770004581 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 441770004582 putative active site [active] 441770004583 oxyanion strand; other site 441770004584 catalytic triad [active] 441770004585 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 441770004586 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 441770004587 catalytic residues [active] 441770004588 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 441770004589 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770004590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770004591 homodimer interface [polypeptide binding]; other site 441770004592 catalytic residue [active] 441770004593 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 441770004594 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 441770004595 substrate binding site [chemical binding]; other site 441770004596 glutamase interaction surface [polypeptide binding]; other site 441770004597 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 441770004598 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 441770004599 metal binding site [ion binding]; metal-binding site 441770004600 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 441770004601 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 441770004602 CPxP motif; other site 441770004603 putative inner membrane protein; Provisional; Region: PRK11099 441770004604 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441770004605 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441770004606 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 441770004607 dimerization interface [polypeptide binding]; other site 441770004608 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 441770004609 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 441770004610 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 441770004611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 441770004612 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441770004613 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 441770004614 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 441770004615 active site residue [active] 441770004616 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 441770004617 Sulphur transport; Region: Sulf_transp; pfam04143 441770004618 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 441770004619 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 441770004620 Walker A/P-loop; other site 441770004621 ATP binding site [chemical binding]; other site 441770004622 Q-loop/lid; other site 441770004623 ABC transporter signature motif; other site 441770004624 Walker B; other site 441770004625 D-loop; other site 441770004626 H-loop/switch region; other site 441770004627 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 441770004628 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 441770004629 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 441770004630 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770004631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770004632 active site 441770004633 phosphorylation site [posttranslational modification] 441770004634 intermolecular recognition site; other site 441770004635 dimerization interface [polypeptide binding]; other site 441770004636 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770004637 DNA binding site [nucleotide binding] 441770004638 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770004639 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 441770004640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770004641 dimer interface [polypeptide binding]; other site 441770004642 phosphorylation site [posttranslational modification] 441770004643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770004644 ATP binding site [chemical binding]; other site 441770004645 Mg2+ binding site [ion binding]; other site 441770004646 G-X-G motif; other site 441770004647 arginine deiminase; Provisional; Region: PRK01388 441770004648 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 441770004649 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 441770004650 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 441770004651 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 441770004652 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 441770004653 HD domain; Region: HD_3; pfam13023 441770004654 YmaF family; Region: YmaF; pfam12788 441770004655 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 441770004656 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 441770004657 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441770004658 ATP binding site [chemical binding]; other site 441770004659 putative Mg++ binding site [ion binding]; other site 441770004660 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441770004661 nucleotide binding region [chemical binding]; other site 441770004662 ATP-binding site [chemical binding]; other site 441770004663 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 441770004664 synthetase active site [active] 441770004665 NTP binding site [chemical binding]; other site 441770004666 metal binding site [ion binding]; metal-binding site 441770004667 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 441770004668 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441770004669 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770004670 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441770004671 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441770004672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770004673 Walker A/P-loop; other site 441770004674 ATP binding site [chemical binding]; other site 441770004675 Q-loop/lid; other site 441770004676 ABC transporter signature motif; other site 441770004677 Walker B; other site 441770004678 D-loop; other site 441770004679 H-loop/switch region; other site 441770004680 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441770004681 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441770004682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770004683 Walker A/P-loop; other site 441770004684 ATP binding site [chemical binding]; other site 441770004685 Q-loop/lid; other site 441770004686 ABC transporter signature motif; other site 441770004687 Walker B; other site 441770004688 D-loop; other site 441770004689 H-loop/switch region; other site 441770004690 Transcriptional regulators [Transcription]; Region: PurR; COG1609 441770004691 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 441770004692 DNA binding site [nucleotide binding] 441770004693 domain linker motif; other site 441770004694 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 441770004695 putative dimerization interface [polypeptide binding]; other site 441770004696 putative ligand binding site [chemical binding]; other site 441770004697 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 441770004698 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 441770004699 nucleotide binding site [chemical binding]; other site 441770004700 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 441770004701 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 441770004702 Ca binding site [ion binding]; other site 441770004703 active site 441770004704 catalytic site [active] 441770004705 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 441770004706 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441770004707 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441770004708 active site turn [active] 441770004709 phosphorylation site [posttranslational modification] 441770004710 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 441770004711 putative catalytic site [active] 441770004712 putative metal binding site [ion binding]; other site 441770004713 putative phosphate binding site [ion binding]; other site 441770004714 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 441770004715 Domain of unknown function DUF; Region: DUF204; pfam02659 441770004716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 441770004717 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 441770004718 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441770004719 dimerization interface [polypeptide binding]; other site 441770004720 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770004721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770004722 dimer interface [polypeptide binding]; other site 441770004723 phosphorylation site [posttranslational modification] 441770004724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770004725 ATP binding site [chemical binding]; other site 441770004726 Mg2+ binding site [ion binding]; other site 441770004727 G-X-G motif; other site 441770004728 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770004729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770004730 active site 441770004731 phosphorylation site [posttranslational modification] 441770004732 intermolecular recognition site; other site 441770004733 dimerization interface [polypeptide binding]; other site 441770004734 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770004735 DNA binding site [nucleotide binding] 441770004736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441770004737 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 441770004738 putative substrate translocation pore; other site 441770004739 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441770004740 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 441770004741 active site 441770004742 motif I; other site 441770004743 motif II; other site 441770004744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441770004745 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 441770004746 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 441770004747 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 441770004748 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 441770004749 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441770004750 DNA binding residues [nucleotide binding] 441770004751 YvrJ protein family; Region: YvrJ; pfam12841 441770004752 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 441770004753 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 441770004754 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 441770004755 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 441770004756 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 441770004757 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 441770004758 FAD binding site [chemical binding]; other site 441770004759 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 441770004760 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 441770004761 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 441770004762 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 441770004763 substrate binding pocket [chemical binding]; other site 441770004764 dimer interface [polypeptide binding]; other site 441770004765 inhibitor binding site; inhibition site 441770004766 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 441770004767 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 441770004768 B12 binding site [chemical binding]; other site 441770004769 RNA polymerase factor sigma-70; Validated; Region: PRK06811 441770004770 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 441770004771 DNA binding residues [nucleotide binding] 441770004772 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 441770004773 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 441770004774 GAF domain; Region: GAF; pfam01590 441770004775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770004776 Walker A motif; other site 441770004777 ATP binding site [chemical binding]; other site 441770004778 Walker B motif; other site 441770004779 arginine finger; other site 441770004780 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441770004781 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 441770004782 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 441770004783 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 441770004784 tetramer interface [polypeptide binding]; other site 441770004785 TPP-binding site [chemical binding]; other site 441770004786 heterodimer interface [polypeptide binding]; other site 441770004787 phosphorylation loop region [posttranslational modification] 441770004788 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 441770004789 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 441770004790 alpha subunit interface [polypeptide binding]; other site 441770004791 TPP binding site [chemical binding]; other site 441770004792 heterodimer interface [polypeptide binding]; other site 441770004793 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 441770004794 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 441770004795 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 441770004796 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 441770004797 E3 interaction surface; other site 441770004798 lipoyl attachment site [posttranslational modification]; other site 441770004799 e3 binding domain; Region: E3_binding; pfam02817 441770004800 e3 binding domain; Region: E3_binding; pfam02817 441770004801 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 441770004802 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 441770004803 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 441770004804 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441770004805 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 441770004806 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 441770004807 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 441770004808 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 441770004809 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 441770004810 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 441770004811 Walker A/P-loop; other site 441770004812 ATP binding site [chemical binding]; other site 441770004813 Q-loop/lid; other site 441770004814 ABC transporter signature motif; other site 441770004815 Walker B; other site 441770004816 D-loop; other site 441770004817 H-loop/switch region; other site 441770004818 FOG: CBS domain [General function prediction only]; Region: COG0517 441770004819 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 441770004820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770004821 ABC-ATPase subunit interface; other site 441770004822 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 441770004823 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 441770004824 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 441770004825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770004826 catalytic residue [active] 441770004827 homoserine kinase; Provisional; Region: PRK01212 441770004828 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 441770004829 aspartate kinase; Reviewed; Region: PRK09034 441770004830 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 441770004831 nucleotide binding site [chemical binding]; other site 441770004832 substrate binding site [chemical binding]; other site 441770004833 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 441770004834 allosteric regulatory residue; other site 441770004835 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 441770004836 homoserine dehydrogenase; Provisional; Region: PRK06349 441770004837 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 441770004838 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 441770004839 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 441770004840 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 441770004841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441770004842 putative active site [active] 441770004843 heme pocket [chemical binding]; other site 441770004844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770004845 Walker A motif; other site 441770004846 ATP binding site [chemical binding]; other site 441770004847 Walker B motif; other site 441770004848 arginine finger; other site 441770004849 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441770004850 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 441770004851 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 441770004852 putative active site [active] 441770004853 metal binding site [ion binding]; metal-binding site 441770004854 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 441770004855 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 441770004856 FAD binding pocket [chemical binding]; other site 441770004857 FAD binding motif [chemical binding]; other site 441770004858 phosphate binding motif [ion binding]; other site 441770004859 beta-alpha-beta structure motif; other site 441770004860 NAD binding pocket [chemical binding]; other site 441770004861 Iron coordination center [ion binding]; other site 441770004862 putative oxidoreductase; Provisional; Region: PRK12831 441770004863 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 441770004864 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 441770004865 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 441770004866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770004867 Walker A motif; other site 441770004868 ATP binding site [chemical binding]; other site 441770004869 Walker B motif; other site 441770004870 arginine finger; other site 441770004871 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441770004872 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 441770004873 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 441770004874 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 441770004875 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 441770004876 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 441770004877 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 441770004878 Bacterial SH3 domain; Region: SH3_3; pfam08239 441770004879 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 441770004880 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441770004881 Hemerythrin-like domain; Region: Hr-like; cd12108 441770004882 Fe binding site [ion binding]; other site 441770004883 alanine racemase; Reviewed; Region: alr; PRK00053 441770004884 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 441770004885 active site 441770004886 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441770004887 dimer interface [polypeptide binding]; other site 441770004888 substrate binding site [chemical binding]; other site 441770004889 catalytic residues [active] 441770004890 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441770004891 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770004892 dimer interface [polypeptide binding]; other site 441770004893 putative CheW interface [polypeptide binding]; other site 441770004894 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 441770004895 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 441770004896 Protein of unknown function (DUF975); Region: DUF975; cl10504 441770004897 short chain dehydrogenase; Provisional; Region: PRK06701 441770004898 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 441770004899 NAD binding site [chemical binding]; other site 441770004900 metal binding site [ion binding]; metal-binding site 441770004901 active site 441770004902 Cache domain; Region: Cache_1; pfam02743 441770004903 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441770004904 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770004905 dimer interface [polypeptide binding]; other site 441770004906 putative CheW interface [polypeptide binding]; other site 441770004907 KWG Leptospira; Region: KWG; pfam07656 441770004908 KWG Leptospira; Region: KWG; pfam07656 441770004909 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 441770004910 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 441770004911 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441770004912 ATP binding site [chemical binding]; other site 441770004913 putative Mg++ binding site [ion binding]; other site 441770004914 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441770004915 nucleotide binding region [chemical binding]; other site 441770004916 ATP-binding site [chemical binding]; other site 441770004917 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 441770004918 homodimer interaction site [polypeptide binding]; other site 441770004919 cofactor binding site; other site 441770004920 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 441770004921 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 441770004922 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 441770004923 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 441770004924 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_21; cd08520 441770004925 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 441770004926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770004927 putative PBP binding loops; other site 441770004928 dimer interface [polypeptide binding]; other site 441770004929 ABC-ATPase subunit interface; other site 441770004930 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 441770004931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770004932 dimer interface [polypeptide binding]; other site 441770004933 conserved gate region; other site 441770004934 putative PBP binding loops; other site 441770004935 ABC-ATPase subunit interface; other site 441770004936 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 441770004937 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441770004938 Walker A/P-loop; other site 441770004939 ATP binding site [chemical binding]; other site 441770004940 Q-loop/lid; other site 441770004941 ABC transporter signature motif; other site 441770004942 Walker B; other site 441770004943 D-loop; other site 441770004944 H-loop/switch region; other site 441770004945 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 441770004946 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441770004947 Walker A/P-loop; other site 441770004948 ATP binding site [chemical binding]; other site 441770004949 Q-loop/lid; other site 441770004950 ABC transporter signature motif; other site 441770004951 Walker B; other site 441770004952 D-loop; other site 441770004953 H-loop/switch region; other site 441770004954 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 441770004955 active site 441770004956 catalytic site [active] 441770004957 substrate binding site [chemical binding]; other site 441770004958 Predicted secreted protein [Function unknown]; Region: COG4086 441770004959 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 441770004960 Methyltransferase domain; Region: Methyltransf_31; pfam13847 441770004961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770004962 S-adenosylmethionine binding site [chemical binding]; other site 441770004963 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 441770004964 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 441770004965 putative dimer interface [polypeptide binding]; other site 441770004966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441770004967 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441770004968 putative substrate translocation pore; other site 441770004969 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441770004970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441770004971 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 441770004972 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 441770004973 putative substrate binding site [chemical binding]; other site 441770004974 putative ATP binding site [chemical binding]; other site 441770004975 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441770004976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441770004977 putative substrate translocation pore; other site 441770004978 Putative amidase domain; Region: Amidase_6; pfam12671 441770004979 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 441770004980 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 441770004981 substrate binding site [chemical binding]; other site 441770004982 ATP binding site [chemical binding]; other site 441770004983 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441770004984 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 441770004985 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 441770004986 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 441770004987 DNA-binding site [nucleotide binding]; DNA binding site 441770004988 RNA-binding motif; other site 441770004989 Cache domain; Region: Cache_1; pfam02743 441770004990 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 441770004991 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770004992 dimer interface [polypeptide binding]; other site 441770004993 putative CheW interface [polypeptide binding]; other site 441770004994 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 441770004995 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441770004996 Pecanex protein (C-terminus); Region: Pecanex_C; pfam05041 441770004997 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441770004998 ABC transporter; Region: ABC_tran_2; pfam12848 441770004999 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441770005000 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 441770005001 putative deacylase active site [active] 441770005002 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 441770005003 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 441770005004 4Fe-4S binding domain; Region: Fer4_6; pfam12837 441770005005 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 441770005006 Response regulator receiver domain; Region: Response_reg; pfam00072 441770005007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770005008 active site 441770005009 phosphorylation site [posttranslational modification] 441770005010 intermolecular recognition site; other site 441770005011 dimerization interface [polypeptide binding]; other site 441770005012 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 441770005013 DEAD-like helicases superfamily; Region: DEXDc; smart00487 441770005014 ATP binding site [chemical binding]; other site 441770005015 putative Mg++ binding site [ion binding]; other site 441770005016 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441770005017 nucleotide binding region [chemical binding]; other site 441770005018 ATP-binding site [chemical binding]; other site 441770005019 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 441770005020 S1 domain; Region: S1_2; pfam13509 441770005021 S1 domain; Region: S1_2; pfam13509 441770005022 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 441770005023 RNA binding site [nucleotide binding]; other site 441770005024 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 441770005025 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 441770005026 ATP binding site [chemical binding]; other site 441770005027 Mg++ binding site [ion binding]; other site 441770005028 motif III; other site 441770005029 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441770005030 nucleotide binding region [chemical binding]; other site 441770005031 ATP-binding site [chemical binding]; other site 441770005032 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 441770005033 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 441770005034 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441770005035 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441770005036 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441770005037 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441770005038 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441770005039 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 441770005040 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441770005041 Leucine rich repeat; Region: LRR_8; pfam13855 441770005042 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441770005043 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441770005044 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441770005045 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 441770005046 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 441770005047 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 441770005048 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 441770005049 Ferritin-like domain; Region: Ferritin; pfam00210 441770005050 ferroxidase diiron center [ion binding]; other site 441770005051 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441770005052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770005053 active site 441770005054 phosphorylation site [posttranslational modification] 441770005055 intermolecular recognition site; other site 441770005056 dimerization interface [polypeptide binding]; other site 441770005057 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 441770005058 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 441770005059 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 441770005060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 441770005061 Nucleoside recognition; Region: Gate; pfam07670 441770005062 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 441770005063 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 441770005064 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 441770005065 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 441770005066 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441770005067 active site 441770005068 DNA binding site [nucleotide binding] 441770005069 Int/Topo IB signature motif; other site 441770005070 LexA repressor; Validated; Region: PRK00215 441770005071 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441770005072 putative Zn2+ binding site [ion binding]; other site 441770005073 putative DNA binding site [nucleotide binding]; other site 441770005074 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 441770005075 Catalytic site [active] 441770005076 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 441770005077 Aluminium resistance protein; Region: Alum_res; pfam06838 441770005078 bacterial Hfq-like; Region: Hfq; cd01716 441770005079 hexamer interface [polypeptide binding]; other site 441770005080 Sm1 motif; other site 441770005081 RNA binding site [nucleotide binding]; other site 441770005082 Sm2 motif; other site 441770005083 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 441770005084 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 441770005085 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 441770005086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770005087 ATP binding site [chemical binding]; other site 441770005088 Mg2+ binding site [ion binding]; other site 441770005089 G-X-G motif; other site 441770005090 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 441770005091 ATP binding site [chemical binding]; other site 441770005092 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 441770005093 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 441770005094 MutS domain I; Region: MutS_I; pfam01624 441770005095 MutS domain II; Region: MutS_II; pfam05188 441770005096 MutS domain III; Region: MutS_III; pfam05192 441770005097 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 441770005098 Walker A/P-loop; other site 441770005099 ATP binding site [chemical binding]; other site 441770005100 Q-loop/lid; other site 441770005101 ABC transporter signature motif; other site 441770005102 Walker B; other site 441770005103 D-loop; other site 441770005104 H-loop/switch region; other site 441770005105 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 441770005106 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 441770005107 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770005108 FeS/SAM binding site; other site 441770005109 TRAM domain; Region: TRAM; pfam01938 441770005110 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 441770005111 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770005112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770005113 homodimer interface [polypeptide binding]; other site 441770005114 catalytic residue [active] 441770005115 aspartate aminotransferase; Provisional; Region: PRK07568 441770005116 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770005117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770005118 homodimer interface [polypeptide binding]; other site 441770005119 catalytic residue [active] 441770005120 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 441770005121 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 441770005122 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 441770005123 LytB protein; Region: LYTB; cl00507 441770005124 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 441770005125 RNA binding site [nucleotide binding]; other site 441770005126 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 441770005127 RNA binding site [nucleotide binding]; other site 441770005128 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 441770005129 RNA binding site [nucleotide binding]; other site 441770005130 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 441770005131 RNA binding site [nucleotide binding]; other site 441770005132 domain interface; other site 441770005133 cytidylate kinase; Provisional; Region: cmk; PRK00023 441770005134 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 441770005135 CMP-binding site; other site 441770005136 The sites determining sugar specificity; other site 441770005137 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 441770005138 homotrimer interaction site [polypeptide binding]; other site 441770005139 active site 441770005140 flavoprotein, HI0933 family; Region: TIGR00275 441770005141 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441770005142 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 441770005143 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 441770005144 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 441770005145 NAD(P) binding site [chemical binding]; other site 441770005146 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 441770005147 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 441770005148 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 441770005149 putative active site [active] 441770005150 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 441770005151 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441770005152 RNA binding surface [nucleotide binding]; other site 441770005153 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 441770005154 active site 441770005155 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 441770005156 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 441770005157 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 441770005158 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 441770005159 DXD motif; other site 441770005160 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 441770005161 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441770005162 dimerization interface [polypeptide binding]; other site 441770005163 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770005164 dimer interface [polypeptide binding]; other site 441770005165 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 441770005166 putative CheW interface [polypeptide binding]; other site 441770005167 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 441770005168 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 441770005169 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 441770005170 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 441770005171 catalytic residues [active] 441770005172 Predicted amidohydrolase [General function prediction only]; Region: COG0388 441770005173 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 441770005174 putative active site [active] 441770005175 catalytic triad [active] 441770005176 dimer interface [polypeptide binding]; other site 441770005177 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 441770005178 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 441770005179 TrkA-C domain; Region: TrkA_C; pfam02080 441770005180 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 441770005181 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 441770005182 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770005183 Coenzyme A binding pocket [chemical binding]; other site 441770005184 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 441770005185 active site residue [active] 441770005186 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 441770005187 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 441770005188 dimer interface [polypeptide binding]; other site 441770005189 [2Fe-2S] cluster binding site [ion binding]; other site 441770005190 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 441770005191 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 441770005192 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 441770005193 Putative Fe-S cluster; Region: FeS; cl17515 441770005194 PAS domain; Region: PAS_9; pfam13426 441770005195 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441770005196 putative active site [active] 441770005197 heme pocket [chemical binding]; other site 441770005198 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 441770005199 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 441770005200 4Fe-4S binding domain; Region: Fer4; pfam00037 441770005201 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 441770005202 Putative Fe-S cluster; Region: FeS; cl17515 441770005203 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441770005204 putative active site [active] 441770005205 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 441770005206 dimerization interface [polypeptide binding]; other site 441770005207 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 441770005208 ATP binding site [chemical binding]; other site 441770005209 Hydrogenase formation hypA family; Region: HypD; pfam01924 441770005210 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 441770005211 HupF/HypC family; Region: HupF_HypC; pfam01455 441770005212 Acylphosphatase; Region: Acylphosphatase; pfam00708 441770005213 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 441770005214 HypF finger; Region: zf-HYPF; pfam07503 441770005215 HypF finger; Region: zf-HYPF; pfam07503 441770005216 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 441770005217 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 441770005218 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 441770005219 nickel binding site [ion binding]; other site 441770005220 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 441770005221 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 441770005222 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 441770005223 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 441770005224 TraX protein; Region: TraX; pfam05857 441770005225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 441770005226 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 441770005227 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441770005228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770005229 Walker A/P-loop; other site 441770005230 ATP binding site [chemical binding]; other site 441770005231 Q-loop/lid; other site 441770005232 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441770005233 ABC transporter signature motif; other site 441770005234 ABC transporter; Region: ABC_tran_2; pfam12848 441770005235 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441770005236 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 441770005237 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441770005238 catalytic loop [active] 441770005239 iron binding site [ion binding]; other site 441770005240 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 441770005241 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 441770005242 4Fe-4S binding domain; Region: Fer4; pfam00037 441770005243 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 441770005244 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 441770005245 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 441770005246 dimer interface [polypeptide binding]; other site 441770005247 [2Fe-2S] cluster binding site [ion binding]; other site 441770005248 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 441770005249 SLBB domain; Region: SLBB; pfam10531 441770005250 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 441770005251 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 441770005252 4Fe-4S binding domain; Region: Fer4; pfam00037 441770005253 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 441770005254 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 441770005255 putative dimer interface [polypeptide binding]; other site 441770005256 [2Fe-2S] cluster binding site [ion binding]; other site 441770005257 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 441770005258 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 441770005259 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 441770005260 Domain of unknown function DUF20; Region: UPF0118; pfam01594 441770005261 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 441770005262 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 441770005263 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 441770005264 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 441770005265 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 441770005266 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 441770005267 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 441770005268 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 441770005269 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 441770005270 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 441770005271 EcsC protein family; Region: EcsC; pfam12787 441770005272 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 441770005273 putative catalytic site [active] 441770005274 putative metal binding site [ion binding]; other site 441770005275 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 441770005276 putative catalytic site [active] 441770005277 putative phosphate binding site [ion binding]; other site 441770005278 putative phosphate binding site [ion binding]; other site 441770005279 putative metal binding site [ion binding]; other site 441770005280 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 441770005281 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 441770005282 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 441770005283 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 441770005284 purine nucleoside phosphorylase; Provisional; Region: PRK08202 441770005285 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 441770005286 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 441770005287 Int/Topo IB signature motif; other site 441770005288 active site 441770005289 stage II sporulation protein M; Region: spo_II_M; TIGR02831 441770005290 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 441770005291 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 441770005292 dimer interface [polypeptide binding]; other site 441770005293 ADP-ribose binding site [chemical binding]; other site 441770005294 active site 441770005295 nudix motif; other site 441770005296 metal binding site [ion binding]; metal-binding site 441770005297 inner membrane transporter YjeM; Provisional; Region: PRK15238 441770005298 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 441770005299 NlpC/P60 family; Region: NLPC_P60; pfam00877 441770005300 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441770005301 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 441770005302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770005303 active site 441770005304 phosphorylation site [posttranslational modification] 441770005305 intermolecular recognition site; other site 441770005306 dimerization interface [polypeptide binding]; other site 441770005307 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 441770005308 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 441770005309 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 441770005310 Homoserine O-succinyltransferase; Region: HTS; pfam04204 441770005311 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 441770005312 conserved cys residue [active] 441770005313 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 441770005314 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 441770005315 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 441770005316 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 441770005317 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 441770005318 homodimer interface [polypeptide binding]; other site 441770005319 substrate-cofactor binding pocket; other site 441770005320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770005321 catalytic residue [active] 441770005322 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 441770005323 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 441770005324 Walker A/P-loop; other site 441770005325 ATP binding site [chemical binding]; other site 441770005326 Q-loop/lid; other site 441770005327 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 441770005328 ABC transporter signature motif; other site 441770005329 Walker B; other site 441770005330 D-loop; other site 441770005331 H-loop/switch region; other site 441770005332 arginine repressor; Provisional; Region: argR; PRK00441 441770005333 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 441770005334 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 441770005335 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 441770005336 ATP-NAD kinase; Region: NAD_kinase; pfam01513 441770005337 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 441770005338 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441770005339 RNA binding surface [nucleotide binding]; other site 441770005340 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 441770005341 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 441770005342 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 441770005343 TPP-binding site; other site 441770005344 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 441770005345 PYR/PP interface [polypeptide binding]; other site 441770005346 dimer interface [polypeptide binding]; other site 441770005347 TPP binding site [chemical binding]; other site 441770005348 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 441770005349 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 441770005350 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 441770005351 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 441770005352 generic binding surface I; other site 441770005353 generic binding surface II; other site 441770005354 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 441770005355 Asp23 family; Region: Asp23; pfam03780 441770005356 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 441770005357 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 441770005358 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 441770005359 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 441770005360 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 441770005361 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 441770005362 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 441770005363 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 441770005364 elongation factor P; Validated; Region: PRK00529 441770005365 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 441770005366 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 441770005367 RNA binding site [nucleotide binding]; other site 441770005368 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 441770005369 RNA binding site [nucleotide binding]; other site 441770005370 Dehydroquinase class II; Region: DHquinase_II; pfam01220 441770005371 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 441770005372 trimer interface [polypeptide binding]; other site 441770005373 active site 441770005374 dimer interface [polypeptide binding]; other site 441770005375 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 441770005376 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 441770005377 ADP binding site [chemical binding]; other site 441770005378 magnesium binding site [ion binding]; other site 441770005379 putative shikimate binding site; other site 441770005380 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 441770005381 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 441770005382 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 441770005383 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 441770005384 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 441770005385 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 441770005386 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 441770005387 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 441770005388 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 441770005389 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 441770005390 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 441770005391 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 441770005392 Walker A motif; other site 441770005393 ATP binding site [chemical binding]; other site 441770005394 Walker B motif; other site 441770005395 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 441770005396 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 441770005397 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 441770005398 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 441770005399 Domain of unknown function (DUF814); Region: DUF814; pfam05670 441770005400 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 441770005401 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 441770005402 dimerization interface 3.5A [polypeptide binding]; other site 441770005403 active site 441770005404 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 441770005405 nucleotide binding site/active site [active] 441770005406 HIT family signature motif; other site 441770005407 catalytic residue [active] 441770005408 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 441770005409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770005410 catalytic residue [active] 441770005411 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 441770005412 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 441770005413 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441770005414 dimerization interface [polypeptide binding]; other site 441770005415 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770005416 dimer interface [polypeptide binding]; other site 441770005417 putative CheW interface [polypeptide binding]; other site 441770005418 clostripain; Region: clostrip; TIGR02806 441770005419 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 441770005420 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770005421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770005422 active site 441770005423 phosphorylation site [posttranslational modification] 441770005424 intermolecular recognition site; other site 441770005425 dimerization interface [polypeptide binding]; other site 441770005426 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770005427 DNA binding site [nucleotide binding] 441770005428 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770005429 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770005430 dimer interface [polypeptide binding]; other site 441770005431 phosphorylation site [posttranslational modification] 441770005432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770005433 ATP binding site [chemical binding]; other site 441770005434 Mg2+ binding site [ion binding]; other site 441770005435 G-X-G motif; other site 441770005436 methionine sulfoxide reductase A; Provisional; Region: PRK14054 441770005437 Response regulator receiver domain; Region: Response_reg; pfam00072 441770005438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770005439 active site 441770005440 phosphorylation site [posttranslational modification] 441770005441 intermolecular recognition site; other site 441770005442 dimerization interface [polypeptide binding]; other site 441770005443 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441770005444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770005445 active site 441770005446 phosphorylation site [posttranslational modification] 441770005447 intermolecular recognition site; other site 441770005448 dimerization interface [polypeptide binding]; other site 441770005449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770005450 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441770005451 dimerization interface [polypeptide binding]; other site 441770005452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770005453 dimer interface [polypeptide binding]; other site 441770005454 phosphorylation site [posttranslational modification] 441770005455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770005456 ATP binding site [chemical binding]; other site 441770005457 Mg2+ binding site [ion binding]; other site 441770005458 G-X-G motif; other site 441770005459 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770005460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770005461 active site 441770005462 phosphorylation site [posttranslational modification] 441770005463 intermolecular recognition site; other site 441770005464 dimerization interface [polypeptide binding]; other site 441770005465 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770005466 DNA binding site [nucleotide binding] 441770005467 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 441770005468 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 441770005469 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 441770005470 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770005471 Walker A/P-loop; other site 441770005472 ATP binding site [chemical binding]; other site 441770005473 Q-loop/lid; other site 441770005474 ABC transporter signature motif; other site 441770005475 Walker B; other site 441770005476 D-loop; other site 441770005477 H-loop/switch region; other site 441770005478 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441770005479 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441770005480 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 441770005481 Walker A/P-loop; other site 441770005482 ATP binding site [chemical binding]; other site 441770005483 Q-loop/lid; other site 441770005484 ABC transporter signature motif; other site 441770005485 Walker B; other site 441770005486 D-loop; other site 441770005487 H-loop/switch region; other site 441770005488 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441770005489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770005490 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 441770005491 Walker A/P-loop; other site 441770005492 ATP binding site [chemical binding]; other site 441770005493 Q-loop/lid; other site 441770005494 ABC transporter signature motif; other site 441770005495 Walker B; other site 441770005496 D-loop; other site 441770005497 H-loop/switch region; other site 441770005498 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441770005499 MarR family; Region: MarR; pfam01047 441770005500 hypothetical protein; Provisional; Region: PRK08328 441770005501 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 441770005502 ATP binding site [chemical binding]; other site 441770005503 substrate interface [chemical binding]; other site 441770005504 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 441770005505 MoaE interaction surface [polypeptide binding]; other site 441770005506 MoeB interaction surface [polypeptide binding]; other site 441770005507 thiocarboxylated glycine; other site 441770005508 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 441770005509 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 441770005510 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 441770005511 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 441770005512 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441770005513 putative active site [active] 441770005514 heme pocket [chemical binding]; other site 441770005515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770005516 Walker A motif; other site 441770005517 ATP binding site [chemical binding]; other site 441770005518 Walker B motif; other site 441770005519 arginine finger; other site 441770005520 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441770005521 MOSC domain; Region: MOSC; pfam03473 441770005522 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 441770005523 trimer interface [polypeptide binding]; other site 441770005524 dimer interface [polypeptide binding]; other site 441770005525 putative active site [active] 441770005526 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 441770005527 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770005528 FeS/SAM binding site; other site 441770005529 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 441770005530 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 441770005531 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 441770005532 dimer interface [polypeptide binding]; other site 441770005533 putative functional site; other site 441770005534 putative MPT binding site; other site 441770005535 PBP superfamily domain; Region: PBP_like; pfam12727 441770005536 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 441770005537 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 441770005538 dimer interface [polypeptide binding]; other site 441770005539 putative functional site; other site 441770005540 putative MPT binding site; other site 441770005541 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 441770005542 MPT binding site; other site 441770005543 trimer interface [polypeptide binding]; other site 441770005544 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 441770005545 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 441770005546 Walker A/P-loop; other site 441770005547 ATP binding site [chemical binding]; other site 441770005548 Q-loop/lid; other site 441770005549 ABC transporter signature motif; other site 441770005550 Walker B; other site 441770005551 D-loop; other site 441770005552 H-loop/switch region; other site 441770005553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770005554 dimer interface [polypeptide binding]; other site 441770005555 conserved gate region; other site 441770005556 putative PBP binding loops; other site 441770005557 ABC-ATPase subunit interface; other site 441770005558 PBP superfamily domain; Region: PBP_like_2; pfam12849 441770005559 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 441770005560 putative efflux protein, MATE family; Region: matE; TIGR00797 441770005561 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 441770005562 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441770005563 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441770005564 Walker A/P-loop; other site 441770005565 ATP binding site [chemical binding]; other site 441770005566 Q-loop/lid; other site 441770005567 ABC transporter signature motif; other site 441770005568 Walker B; other site 441770005569 D-loop; other site 441770005570 H-loop/switch region; other site 441770005571 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 441770005572 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 441770005573 FtsX-like permease family; Region: FtsX; pfam02687 441770005574 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441770005575 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441770005576 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 441770005577 Walker A/P-loop; other site 441770005578 ATP binding site [chemical binding]; other site 441770005579 Q-loop/lid; other site 441770005580 ABC transporter signature motif; other site 441770005581 Walker B; other site 441770005582 D-loop; other site 441770005583 H-loop/switch region; other site 441770005584 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441770005585 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441770005586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770005587 Walker A/P-loop; other site 441770005588 ATP binding site [chemical binding]; other site 441770005589 Q-loop/lid; other site 441770005590 ABC transporter signature motif; other site 441770005591 Walker B; other site 441770005592 D-loop; other site 441770005593 H-loop/switch region; other site 441770005594 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 441770005595 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 441770005596 DNA binding residues [nucleotide binding] 441770005597 dimer interface [polypeptide binding]; other site 441770005598 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 441770005599 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 441770005600 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 441770005601 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441770005602 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441770005603 M6 family metalloprotease domain; Region: M6dom_TIGR03296 441770005604 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 441770005605 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 441770005606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770005607 Walker A motif; other site 441770005608 ATP binding site [chemical binding]; other site 441770005609 Walker B motif; other site 441770005610 arginine finger; other site 441770005611 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 441770005612 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 441770005613 homotrimer interaction site [polypeptide binding]; other site 441770005614 putative active site [active] 441770005615 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 441770005616 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 441770005617 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 441770005618 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770005619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770005620 homodimer interface [polypeptide binding]; other site 441770005621 catalytic residue [active] 441770005622 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 441770005623 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 441770005624 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441770005625 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441770005626 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441770005627 M6 family metalloprotease domain; Region: M6dom_TIGR03296 441770005628 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 441770005629 dimerization interface [polypeptide binding]; other site 441770005630 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770005631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770005632 dimer interface [polypeptide binding]; other site 441770005633 phosphorylation site [posttranslational modification] 441770005634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770005635 ATP binding site [chemical binding]; other site 441770005636 Mg2+ binding site [ion binding]; other site 441770005637 G-X-G motif; other site 441770005638 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770005639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770005640 active site 441770005641 phosphorylation site [posttranslational modification] 441770005642 intermolecular recognition site; other site 441770005643 dimerization interface [polypeptide binding]; other site 441770005644 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770005645 DNA binding site [nucleotide binding] 441770005646 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 441770005647 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 441770005648 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 441770005649 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 441770005650 Walker A/P-loop; other site 441770005651 ATP binding site [chemical binding]; other site 441770005652 Q-loop/lid; other site 441770005653 ABC transporter signature motif; other site 441770005654 Walker B; other site 441770005655 D-loop; other site 441770005656 H-loop/switch region; other site 441770005657 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 441770005658 Walker A/P-loop; other site 441770005659 ATP binding site [chemical binding]; other site 441770005660 Q-loop/lid; other site 441770005661 ABC transporter signature motif; other site 441770005662 Walker B; other site 441770005663 D-loop; other site 441770005664 H-loop/switch region; other site 441770005665 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 441770005666 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 441770005667 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 441770005668 dimer interface [polypeptide binding]; other site 441770005669 active site 441770005670 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441770005671 substrate binding site [chemical binding]; other site 441770005672 catalytic residue [active] 441770005673 Spore germination protein; Region: Spore_permease; cl17796 441770005674 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 441770005675 Spore germination protein; Region: Spore_permease; cl17796 441770005676 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 441770005677 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 441770005678 Spore germination protein; Region: Spore_permease; cl17796 441770005679 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 441770005680 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 441770005681 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 441770005682 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770005683 FeS/SAM binding site; other site 441770005684 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 441770005685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441770005686 binding surface 441770005687 TPR repeat; Region: TPR_11; pfam13414 441770005688 TPR motif; other site 441770005689 Tetratricopeptide repeat; Region: TPR_16; pfam13432 441770005690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441770005691 binding surface 441770005692 TPR motif; other site 441770005693 TPR repeat; Region: TPR_11; pfam13414 441770005694 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 441770005695 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 441770005696 TrkA-C domain; Region: TrkA_C; pfam02080 441770005697 heat shock protein 90; Provisional; Region: PRK05218 441770005698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770005699 ATP binding site [chemical binding]; other site 441770005700 Mg2+ binding site [ion binding]; other site 441770005701 G-X-G motif; other site 441770005702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770005703 Walker A/P-loop; other site 441770005704 ATP binding site [chemical binding]; other site 441770005705 Q-loop/lid; other site 441770005706 ABC transporter signature motif; other site 441770005707 Walker B; other site 441770005708 D-loop; other site 441770005709 H-loop/switch region; other site 441770005710 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 441770005711 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441770005712 active site turn [active] 441770005713 phosphorylation site [posttranslational modification] 441770005714 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441770005715 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 441770005716 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 441770005717 Ca binding site [ion binding]; other site 441770005718 active site 441770005719 catalytic site [active] 441770005720 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 441770005721 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770005722 DNA-binding site [nucleotide binding]; DNA binding site 441770005723 UTRA domain; Region: UTRA; pfam07702 441770005724 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 441770005725 active site 441770005726 phosphorylation site [posttranslational modification] 441770005727 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 441770005728 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 441770005729 active site 441770005730 P-loop; other site 441770005731 phosphorylation site [posttranslational modification] 441770005732 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 441770005733 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 441770005734 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 441770005735 putative substrate binding site [chemical binding]; other site 441770005736 putative ATP binding site [chemical binding]; other site 441770005737 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 441770005738 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 441770005739 intersubunit interface [polypeptide binding]; other site 441770005740 active site 441770005741 zinc binding site [ion binding]; other site 441770005742 Na+ binding site [ion binding]; other site 441770005743 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 441770005744 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 441770005745 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 441770005746 putative active site [active] 441770005747 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 441770005748 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 441770005749 homotrimer interaction site [polypeptide binding]; other site 441770005750 putative active site [active] 441770005751 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770005752 Radical SAM superfamily; Region: Radical_SAM; pfam04055 441770005753 FeS/SAM binding site; other site 441770005754 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 441770005755 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 441770005756 dimer interface [polypeptide binding]; other site 441770005757 active site 441770005758 metal binding site [ion binding]; metal-binding site 441770005759 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441770005760 dimerization interface [polypeptide binding]; other site 441770005761 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441770005762 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770005763 dimer interface [polypeptide binding]; other site 441770005764 putative CheW interface [polypeptide binding]; other site 441770005765 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 441770005766 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 441770005767 dimer interface [polypeptide binding]; other site 441770005768 active site 441770005769 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441770005770 substrate binding site [chemical binding]; other site 441770005771 catalytic residue [active] 441770005772 ATP cone domain; Region: ATP-cone; pfam03477 441770005773 putative oxidoreductase; Provisional; Region: PRK11579 441770005774 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 441770005775 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 441770005776 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441770005777 active site 441770005778 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 441770005779 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441770005780 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441770005781 metal binding site [ion binding]; metal-binding site 441770005782 active site 441770005783 I-site; other site 441770005784 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 441770005785 PAS domain; Region: PAS; smart00091 441770005786 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 441770005787 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770005788 Walker A motif; other site 441770005789 ATP binding site [chemical binding]; other site 441770005790 Walker B motif; other site 441770005791 arginine finger; other site 441770005792 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 441770005793 DEAD-like helicases superfamily; Region: DEXDc; smart00487 441770005794 ATP binding site [chemical binding]; other site 441770005795 Mg++ binding site [ion binding]; other site 441770005796 motif III; other site 441770005797 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441770005798 nucleotide binding region [chemical binding]; other site 441770005799 ATP-binding site [chemical binding]; other site 441770005800 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 441770005801 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 441770005802 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 441770005803 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770005804 DNA-binding site [nucleotide binding]; DNA binding site 441770005805 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770005806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770005807 homodimer interface [polypeptide binding]; other site 441770005808 catalytic residue [active] 441770005809 EamA-like transporter family; Region: EamA; pfam00892 441770005810 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 441770005811 EamA-like transporter family; Region: EamA; pfam00892 441770005812 aspartate aminotransferase; Provisional; Region: PRK06348 441770005813 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770005814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770005815 homodimer interface [polypeptide binding]; other site 441770005816 catalytic residue [active] 441770005817 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 441770005818 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 441770005819 Walker A/P-loop; other site 441770005820 ATP binding site [chemical binding]; other site 441770005821 Q-loop/lid; other site 441770005822 ABC transporter signature motif; other site 441770005823 Walker B; other site 441770005824 D-loop; other site 441770005825 H-loop/switch region; other site 441770005826 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 441770005827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770005828 dimer interface [polypeptide binding]; other site 441770005829 conserved gate region; other site 441770005830 putative PBP binding loops; other site 441770005831 ABC-ATPase subunit interface; other site 441770005832 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 441770005833 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441770005834 substrate binding pocket [chemical binding]; other site 441770005835 membrane-bound complex binding site; other site 441770005836 hinge residues; other site 441770005837 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 441770005838 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 441770005839 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441770005840 catalytic residue [active] 441770005841 Chloramphenicol acetyltransferase; Region: CAT; cl02008 441770005842 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 441770005843 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 441770005844 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 441770005845 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 441770005846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770005847 sequence-specific DNA binding site [nucleotide binding]; other site 441770005848 salt bridge; other site 441770005849 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 441770005850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441770005851 putative substrate translocation pore; other site 441770005852 POT family; Region: PTR2; cl17359 441770005853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441770005854 POT family; Region: PTR2; cl17359 441770005855 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 441770005856 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 441770005857 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 441770005858 active site 441770005859 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 441770005860 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 441770005861 Na2 binding site [ion binding]; other site 441770005862 putative substrate binding site 1 [chemical binding]; other site 441770005863 Na binding site 1 [ion binding]; other site 441770005864 putative substrate binding site 2 [chemical binding]; other site 441770005865 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 441770005866 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770005867 DNA-binding site [nucleotide binding]; DNA binding site 441770005868 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770005869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770005870 homodimer interface [polypeptide binding]; other site 441770005871 catalytic residue [active] 441770005872 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 441770005873 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 441770005874 nucleophilic elbow; other site 441770005875 catalytic triad; other site 441770005876 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 441770005877 putative FMN binding site [chemical binding]; other site 441770005878 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 441770005879 metal ion-dependent adhesion site (MIDAS); other site 441770005880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 441770005881 myosin-cross-reactive antigen; Provisional; Region: PRK13977 441770005882 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 441770005883 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441770005884 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 441770005885 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 441770005886 active site 441770005887 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 441770005888 active site 441770005889 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 441770005890 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 441770005891 putative trimer interface [polypeptide binding]; other site 441770005892 putative CoA binding site [chemical binding]; other site 441770005893 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 441770005894 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 441770005895 inhibitor-cofactor binding pocket; inhibition site 441770005896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770005897 catalytic residue [active] 441770005898 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441770005899 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 441770005900 active site 441770005901 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 441770005902 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 441770005903 substrate binding site; other site 441770005904 metal-binding site 441770005905 Oligomer interface; other site 441770005906 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 441770005907 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 441770005908 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 441770005909 NAD binding site [chemical binding]; other site 441770005910 substrate binding site [chemical binding]; other site 441770005911 homodimer interface [polypeptide binding]; other site 441770005912 active site 441770005913 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 441770005914 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 441770005915 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 441770005916 PGAP1-like protein; Region: PGAP1; pfam07819 441770005917 VanZ like family; Region: VanZ; pfam04892 441770005918 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 441770005919 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 441770005920 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441770005921 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441770005922 Walker A/P-loop; other site 441770005923 ATP binding site [chemical binding]; other site 441770005924 Q-loop/lid; other site 441770005925 ABC transporter signature motif; other site 441770005926 Walker B; other site 441770005927 D-loop; other site 441770005928 H-loop/switch region; other site 441770005929 Predicted transcriptional regulators [Transcription]; Region: COG1725 441770005930 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770005931 DNA-binding site [nucleotide binding]; DNA binding site 441770005932 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 441770005933 glycosyltransferase, MGT family; Region: MGT; TIGR01426 441770005934 active site 441770005935 TDP-binding site; other site 441770005936 acceptor substrate-binding pocket; other site 441770005937 homodimer interface [polypeptide binding]; other site 441770005938 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 441770005939 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 441770005940 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 441770005941 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 441770005942 cytosine deaminase; Provisional; Region: PRK09230 441770005943 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 441770005944 active site 441770005945 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 441770005946 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 441770005947 Na binding site [ion binding]; other site 441770005948 putative substrate binding site [chemical binding]; other site 441770005949 Radical SAM superfamily; Region: Radical_SAM; pfam04055 441770005950 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770005951 FeS/SAM binding site; other site 441770005952 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 441770005953 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 441770005954 Walker A/P-loop; other site 441770005955 ATP binding site [chemical binding]; other site 441770005956 Q-loop/lid; other site 441770005957 ABC transporter signature motif; other site 441770005958 Walker B; other site 441770005959 D-loop; other site 441770005960 H-loop/switch region; other site 441770005961 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 441770005962 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 441770005963 Walker A/P-loop; other site 441770005964 ATP binding site [chemical binding]; other site 441770005965 Q-loop/lid; other site 441770005966 ABC transporter signature motif; other site 441770005967 Walker B; other site 441770005968 D-loop; other site 441770005969 H-loop/switch region; other site 441770005970 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 441770005971 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 441770005972 Helix-turn-helix domain; Region: HTH_18; pfam12833 441770005973 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770005974 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 441770005975 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770005976 Coenzyme A binding pocket [chemical binding]; other site 441770005977 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 441770005978 active site 441770005979 8-oxo-dGMP binding site [chemical binding]; other site 441770005980 nudix motif; other site 441770005981 metal binding site [ion binding]; metal-binding site 441770005982 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 441770005983 PLD-like domain; Region: PLDc_2; pfam13091 441770005984 putative homodimer interface [polypeptide binding]; other site 441770005985 putative active site [active] 441770005986 catalytic site [active] 441770005987 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 441770005988 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441770005989 ATP binding site [chemical binding]; other site 441770005990 putative Mg++ binding site [ion binding]; other site 441770005991 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441770005992 nucleotide binding region [chemical binding]; other site 441770005993 ATP-binding site [chemical binding]; other site 441770005994 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 441770005995 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 441770005996 Part of AAA domain; Region: AAA_19; pfam13245 441770005997 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 441770005998 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 441770005999 putative active site [active] 441770006000 putative metal-binding site [ion binding]; other site 441770006001 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 441770006002 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 441770006003 active site 441770006004 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770006005 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441770006006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770006007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 441770006008 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 441770006009 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 441770006010 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441770006011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441770006012 NAD(P) binding site [chemical binding]; other site 441770006013 active site 441770006014 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 441770006015 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 441770006016 active site 441770006017 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 441770006018 active site 441770006019 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 441770006020 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 441770006021 active site 441770006022 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441770006023 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 441770006024 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 441770006025 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 441770006026 G1 box; other site 441770006027 putative GEF interaction site [polypeptide binding]; other site 441770006028 GTP/Mg2+ binding site [chemical binding]; other site 441770006029 Switch I region; other site 441770006030 G2 box; other site 441770006031 G3 box; other site 441770006032 Switch II region; other site 441770006033 G4 box; other site 441770006034 G5 box; other site 441770006035 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 441770006036 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 441770006037 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 441770006038 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 441770006039 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 441770006040 aromatic chitin/cellulose binding site residues [chemical binding]; other site 441770006041 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 441770006042 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 441770006043 Hexamer interface [polypeptide binding]; other site 441770006044 Putative hexagonal pore residue; other site 441770006045 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 441770006046 Propanediol utilisation protein PduL; Region: PduL; pfam06130 441770006047 Propanediol utilisation protein PduL; Region: PduL; pfam06130 441770006048 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 441770006049 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 441770006050 putative catalytic cysteine [active] 441770006051 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 441770006052 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 441770006053 Hexamer interface [polypeptide binding]; other site 441770006054 Hexagonal pore residue; other site 441770006055 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 441770006056 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 441770006057 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 441770006058 Hexamer/Pentamer interface [polypeptide binding]; other site 441770006059 central pore; other site 441770006060 Bacterial Micro-Compartment (BMC)-like domain 2; Region: BMC_like_2; cd07055 441770006061 putative hexamer interface [polypeptide binding]; other site 441770006062 putative hexagonal pore; other site 441770006063 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 441770006064 Cell division protein FtsA; Region: FtsA; cl17206 441770006065 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 441770006066 nucleotide binding site [chemical binding]; other site 441770006067 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 441770006068 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 441770006069 G1 box; other site 441770006070 GTP/Mg2+ binding site [chemical binding]; other site 441770006071 G2 box; other site 441770006072 Switch I region; other site 441770006073 G3 box; other site 441770006074 Switch II region; other site 441770006075 G4 box; other site 441770006076 G5 box; other site 441770006077 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 441770006078 putative hexamer interface [polypeptide binding]; other site 441770006079 putative hexagonal pore; other site 441770006080 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 441770006081 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 441770006082 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 441770006083 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 441770006084 dimer interface [polypeptide binding]; other site 441770006085 active site 441770006086 glycine loop; other site 441770006087 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 441770006088 putative catalytic cysteine [active] 441770006089 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 441770006090 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 441770006091 Hexamer interface [polypeptide binding]; other site 441770006092 Hexagonal pore residue; other site 441770006093 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 441770006094 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 441770006095 Hexamer interface [polypeptide binding]; other site 441770006096 Hexagonal pore residue; other site 441770006097 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 441770006098 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 441770006099 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 441770006100 DNA binding residues [nucleotide binding] 441770006101 drug binding residues [chemical binding]; other site 441770006102 dimer interface [polypeptide binding]; other site 441770006103 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 441770006104 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 441770006105 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 441770006106 putative active site [active] 441770006107 metal binding site [ion binding]; metal-binding site 441770006108 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441770006109 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 441770006110 MarR family; Region: MarR_2; pfam12802 441770006111 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770006112 Coenzyme A binding pocket [chemical binding]; other site 441770006113 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 441770006114 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 441770006115 Helix-turn-helix domain; Region: HTH_17; pfam12728 441770006116 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 441770006117 active site 441770006118 catalytic site [active] 441770006119 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 441770006120 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 441770006121 active site 441770006122 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770006123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 441770006124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770006125 ATP binding site [chemical binding]; other site 441770006126 Mg2+ binding site [ion binding]; other site 441770006127 G-X-G motif; other site 441770006128 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770006129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770006130 active site 441770006131 phosphorylation site [posttranslational modification] 441770006132 intermolecular recognition site; other site 441770006133 dimerization interface [polypeptide binding]; other site 441770006134 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770006135 DNA binding site [nucleotide binding] 441770006136 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 441770006137 Zn binding site [ion binding]; other site 441770006138 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441770006139 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 441770006140 Walker A/P-loop; other site 441770006141 ATP binding site [chemical binding]; other site 441770006142 Q-loop/lid; other site 441770006143 ABC transporter signature motif; other site 441770006144 Walker B; other site 441770006145 D-loop; other site 441770006146 H-loop/switch region; other site 441770006147 FtsX-like permease family; Region: FtsX; pfam02687 441770006148 putative oxidoreductase; Provisional; Region: PRK11445 441770006149 TrkA-N domain; Region: TrkA_N; pfam02254 441770006150 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 441770006151 Predicted transcriptional regulator [Transcription]; Region: COG3655 441770006152 salt bridge; other site 441770006153 non-specific DNA binding site [nucleotide binding]; other site 441770006154 sequence-specific DNA binding site [nucleotide binding]; other site 441770006155 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 441770006156 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 441770006157 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 441770006158 NAD(P) binding site [chemical binding]; other site 441770006159 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 441770006160 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 441770006161 Metal-binding active site; metal-binding site 441770006162 2-deoxy-scyllo-inosose synthase (DOIS) catalyzes carbocycle formation from D-glucose-6-phosphate to 2-deoxy-scyllo-inosose through a multistep reaction in the biosynthesis of aminoglycoside antibiotics; Region: DOIS; cd08197 441770006163 active site 441770006164 dimer interface [polypeptide binding]; other site 441770006165 metal binding site [ion binding]; metal-binding site 441770006166 FtsX-like permease family; Region: FtsX; pfam02687 441770006167 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441770006168 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441770006169 Walker A/P-loop; other site 441770006170 ATP binding site [chemical binding]; other site 441770006171 Q-loop/lid; other site 441770006172 ABC transporter signature motif; other site 441770006173 Walker B; other site 441770006174 D-loop; other site 441770006175 H-loop/switch region; other site 441770006176 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 441770006177 HTH domain; Region: HTH_11; pfam08279 441770006178 HTH domain; Region: HTH_11; pfam08279 441770006179 PRD domain; Region: PRD; pfam00874 441770006180 PRD domain; Region: PRD; pfam00874 441770006181 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 441770006182 active site 441770006183 P-loop; other site 441770006184 phosphorylation site [posttranslational modification] 441770006185 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 441770006186 active site 441770006187 phosphorylation site [posttranslational modification] 441770006188 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 441770006189 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 441770006190 active site 441770006191 P-loop; other site 441770006192 phosphorylation site [posttranslational modification] 441770006193 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 441770006194 active site 441770006195 phosphorylation site [posttranslational modification] 441770006196 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 441770006197 active site 441770006198 intersubunit interactions; other site 441770006199 catalytic residue [active] 441770006200 membrane protein; Provisional; Region: PRK14413 441770006201 PUA domain (predicted RNA-binding domain) [Translation, ribosomal structure and biogenesis]; Region: COG5270 441770006202 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 441770006203 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 441770006204 active site 441770006205 substrate binding site [chemical binding]; other site 441770006206 trimer interface [polypeptide binding]; other site 441770006207 CoA binding site [chemical binding]; other site 441770006208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441770006209 POT family; Region: PTR2; cl17359 441770006210 Methyltransferase domain; Region: Methyltransf_23; pfam13489 441770006211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770006212 S-adenosylmethionine binding site [chemical binding]; other site 441770006213 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441770006214 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770006215 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 441770006216 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 441770006217 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 441770006218 phosphate binding site [ion binding]; other site 441770006219 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441770006220 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441770006221 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 441770006222 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 441770006223 DNA binding residues [nucleotide binding] 441770006224 dimer interface [polypeptide binding]; other site 441770006225 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 441770006226 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cl01317 441770006227 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 441770006228 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 441770006229 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 441770006230 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 441770006231 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 441770006232 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 441770006233 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 441770006234 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 441770006235 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 441770006236 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770006237 DNA-binding site [nucleotide binding]; DNA binding site 441770006238 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 441770006239 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770006240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770006241 homodimer interface [polypeptide binding]; other site 441770006242 catalytic residue [active] 441770006243 Staygreen protein; Region: Staygreen; pfam12638 441770006244 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441770006245 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770006246 non-specific DNA binding site [nucleotide binding]; other site 441770006247 salt bridge; other site 441770006248 sequence-specific DNA binding site [nucleotide binding]; other site 441770006249 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 441770006250 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 441770006251 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 441770006252 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 441770006253 active site 441770006254 putative substrate binding pocket [chemical binding]; other site 441770006255 xanthine permease; Region: pbuX; TIGR03173 441770006256 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 441770006257 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 441770006258 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 441770006259 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 441770006260 Uncharacterized membrane protein [Function unknown]; Region: COG3949 441770006261 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 441770006262 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 441770006263 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 441770006264 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 441770006265 Ligand binding site [chemical binding]; other site 441770006266 Electron transfer flavoprotein domain; Region: ETF; pfam01012 441770006267 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 441770006268 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 441770006269 active site 441770006270 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 441770006271 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441770006272 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 441770006273 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441770006274 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 441770006275 CoA-transferase family III; Region: CoA_transf_3; pfam02515 441770006276 Flavodoxin domain; Region: Flavodoxin_5; cl17428 441770006277 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 441770006278 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441770006279 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 441770006280 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441770006281 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441770006282 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 441770006283 nucleotide binding site [chemical binding]; other site 441770006284 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 441770006285 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770006286 dimer interface [polypeptide binding]; other site 441770006287 putative CheW interface [polypeptide binding]; other site 441770006288 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 441770006289 dimer interface [polypeptide binding]; other site 441770006290 FMN binding site [chemical binding]; other site 441770006291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770006292 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 441770006293 Coenzyme A binding pocket [chemical binding]; other site 441770006294 GntP family permease; Region: GntP_permease; pfam02447 441770006295 fructuronate transporter; Provisional; Region: PRK10034; cl15264 441770006296 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 441770006297 Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995 441770006298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 441770006299 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 441770006300 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 441770006301 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 441770006302 CAAX protease self-immunity; Region: Abi; pfam02517 441770006303 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 441770006304 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 441770006305 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441770006306 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441770006307 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441770006308 WHG domain; Region: WHG; pfam13305 441770006309 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 441770006310 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 441770006311 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 441770006312 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 441770006313 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 441770006314 putative NAD(P) binding site [chemical binding]; other site 441770006315 catalytic Zn binding site [ion binding]; other site 441770006316 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 441770006317 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 441770006318 ACS interaction site; other site 441770006319 CODH interaction site; other site 441770006320 cubane metal cluster (B-cluster) [ion binding]; other site 441770006321 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 441770006322 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 441770006323 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 441770006324 Transmembrane protein 55A; Region: Tmemb_55A; pfam09788 441770006325 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441770006326 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 441770006327 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 441770006328 P loop nucleotide binding; other site 441770006329 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 441770006330 switch II; other site 441770006331 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 441770006332 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 441770006333 P loop nucleotide binding; other site 441770006334 switch II; other site 441770006335 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 441770006336 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 441770006337 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 441770006338 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 441770006339 ligand binding site [chemical binding]; other site 441770006340 flagellar motor protein MotA; Validated; Region: PRK08124 441770006341 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 441770006342 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441770006343 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 441770006344 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441770006345 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441770006346 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 441770006347 OPT oligopeptide transporter protein; Region: OPT; cl14607 441770006348 putative oligopeptide transporter, OPT family; Region: TIGR00733 441770006349 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 441770006350 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 441770006351 metal binding site [ion binding]; metal-binding site 441770006352 dimer interface [polypeptide binding]; other site 441770006353 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 441770006354 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 441770006355 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441770006356 catalytic residue [active] 441770006357 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 441770006358 oxidoreductase; Provisional; Region: PRK08017 441770006359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441770006360 NAD(P) binding site [chemical binding]; other site 441770006361 active site 441770006362 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 441770006363 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 441770006364 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 441770006365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770006366 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441770006367 Walker A/P-loop; other site 441770006368 ATP binding site [chemical binding]; other site 441770006369 Q-loop/lid; other site 441770006370 ABC transporter signature motif; other site 441770006371 Walker B; other site 441770006372 D-loop; other site 441770006373 H-loop/switch region; other site 441770006374 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770006375 Coenzyme A binding pocket [chemical binding]; other site 441770006376 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441770006377 MarR family; Region: MarR_2; pfam12802 441770006378 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 441770006379 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 441770006380 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 441770006381 Predicted dehydrogenase [General function prediction only]; Region: COG0579 441770006382 hydroxyglutarate oxidase; Provisional; Region: PRK11728 441770006383 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 441770006384 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 441770006385 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 441770006386 DNA binding residues [nucleotide binding] 441770006387 drug binding residues [chemical binding]; other site 441770006388 dimer interface [polypeptide binding]; other site 441770006389 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 441770006390 Amino acid permease; Region: AA_permease_2; pfam13520 441770006391 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 441770006392 putative ADP-ribose binding site [chemical binding]; other site 441770006393 putative active site [active] 441770006394 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 441770006395 MarR family; Region: MarR_2; cl17246 441770006396 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441770006397 TIGR03987 family protein; Region: TIGR03987 441770006398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770006399 Walker A/P-loop; other site 441770006400 ATP binding site [chemical binding]; other site 441770006401 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 441770006402 substrate binding site [chemical binding]; other site 441770006403 multimerization interface [polypeptide binding]; other site 441770006404 ATP binding site [chemical binding]; other site 441770006405 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 441770006406 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 441770006407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770006408 Coenzyme A binding pocket [chemical binding]; other site 441770006409 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441770006410 Mor transcription activator family; Region: Mor; cl02360 441770006411 AAA domain; Region: AAA_26; pfam13500 441770006412 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 441770006413 biotin synthase; Region: bioB; TIGR00433 441770006414 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770006415 FeS/SAM binding site; other site 441770006416 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 441770006417 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 441770006418 hypothetical protein; Provisional; Region: PRK09272 441770006419 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441770006420 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441770006421 putative DNA binding site [nucleotide binding]; other site 441770006422 putative Zn2+ binding site [ion binding]; other site 441770006423 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 441770006424 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 441770006425 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 441770006426 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 441770006427 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 441770006428 active site 441770006429 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 441770006430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441770006431 putative substrate translocation pore; other site 441770006432 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 441770006433 YmaF family; Region: YmaF; pfam12788 441770006434 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 441770006435 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 441770006436 active site 441770006437 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 441770006438 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 441770006439 YmaF family; Region: YmaF; pfam12788 441770006440 hypothetical protein; Provisional; Region: PRK05802 441770006441 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 441770006442 FAD binding pocket [chemical binding]; other site 441770006443 FAD binding motif [chemical binding]; other site 441770006444 phosphate binding motif [ion binding]; other site 441770006445 beta-alpha-beta structure motif; other site 441770006446 NAD binding pocket [chemical binding]; other site 441770006447 Iron coordination center [ion binding]; other site 441770006448 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 441770006449 methionine sulfoxide reductase B; Provisional; Region: PRK00222 441770006450 SelR domain; Region: SelR; pfam01641 441770006451 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 441770006452 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 441770006453 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 441770006454 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441770006455 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441770006456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770006457 Walker A/P-loop; other site 441770006458 ATP binding site [chemical binding]; other site 441770006459 Q-loop/lid; other site 441770006460 ABC transporter signature motif; other site 441770006461 Walker B; other site 441770006462 D-loop; other site 441770006463 H-loop/switch region; other site 441770006464 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441770006465 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441770006466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770006467 Walker A/P-loop; other site 441770006468 ATP binding site [chemical binding]; other site 441770006469 Q-loop/lid; other site 441770006470 ABC transporter signature motif; other site 441770006471 Walker B; other site 441770006472 D-loop; other site 441770006473 H-loop/switch region; other site 441770006474 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441770006475 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770006476 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 441770006477 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 441770006478 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441770006479 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 441770006480 Walker A/P-loop; other site 441770006481 ATP binding site [chemical binding]; other site 441770006482 Q-loop/lid; other site 441770006483 ABC transporter signature motif; other site 441770006484 Walker B; other site 441770006485 D-loop; other site 441770006486 H-loop/switch region; other site 441770006487 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770006488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770006489 dimer interface [polypeptide binding]; other site 441770006490 phosphorylation site [posttranslational modification] 441770006491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770006492 ATP binding site [chemical binding]; other site 441770006493 Mg2+ binding site [ion binding]; other site 441770006494 G-X-G motif; other site 441770006495 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770006496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770006497 active site 441770006498 phosphorylation site [posttranslational modification] 441770006499 intermolecular recognition site; other site 441770006500 dimerization interface [polypeptide binding]; other site 441770006501 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770006502 DNA binding site [nucleotide binding] 441770006503 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 441770006504 active site 441770006505 catalytic site [active] 441770006506 substrate binding site [chemical binding]; other site 441770006507 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 441770006508 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 441770006509 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 441770006510 active site 441770006511 catalytic residues [active] 441770006512 metal binding site [ion binding]; metal-binding site 441770006513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770006514 non-specific DNA binding site [nucleotide binding]; other site 441770006515 salt bridge; other site 441770006516 sequence-specific DNA binding site [nucleotide binding]; other site 441770006517 transglutaminase; Provisional; Region: tgl; PRK03187 441770006518 short chain dehydrogenase; Provisional; Region: PRK06701 441770006519 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 441770006520 NAD binding site [chemical binding]; other site 441770006521 metal binding site [ion binding]; metal-binding site 441770006522 active site 441770006523 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 441770006524 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 441770006525 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 441770006526 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441770006527 Spore germination protein; Region: Spore_permease; pfam03845 441770006528 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 441770006529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770006530 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 441770006531 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 441770006532 active site 441770006533 NTP binding site [chemical binding]; other site 441770006534 metal binding triad [ion binding]; metal-binding site 441770006535 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 441770006536 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441770006537 Zn2+ binding site [ion binding]; other site 441770006538 Mg2+ binding site [ion binding]; other site 441770006539 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 441770006540 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 441770006541 Src Homology 3 domain superfamily; Region: SH3; cl17036 441770006542 Predicted transcriptional regulators [Transcription]; Region: COG1695 441770006543 Transcriptional regulator PadR-like family; Region: PadR; cl17335 441770006544 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 441770006545 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770006546 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770006547 dimer interface [polypeptide binding]; other site 441770006548 phosphorylation site [posttranslational modification] 441770006549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770006550 ATP binding site [chemical binding]; other site 441770006551 Mg2+ binding site [ion binding]; other site 441770006552 G-X-G motif; other site 441770006553 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770006554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770006555 active site 441770006556 phosphorylation site [posttranslational modification] 441770006557 intermolecular recognition site; other site 441770006558 dimerization interface [polypeptide binding]; other site 441770006559 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770006560 DNA binding site [nucleotide binding] 441770006561 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 441770006562 hypothetical protein; Provisional; Region: PRK06921 441770006563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770006564 Walker A motif; other site 441770006565 ATP binding site [chemical binding]; other site 441770006566 Walker B motif; other site 441770006567 arginine finger; other site 441770006568 Glucose inhibited division protein A; Region: GIDA; pfam01134 441770006569 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 441770006570 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 441770006571 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 441770006572 tetramer interface [polypeptide binding]; other site 441770006573 active site 441770006574 Uncharacterized conserved protein [Function unknown]; Region: COG2155 441770006575 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 441770006576 dimerization domain swap beta strand [polypeptide binding]; other site 441770006577 regulatory protein interface [polypeptide binding]; other site 441770006578 active site 441770006579 regulatory phosphorylation site [posttranslational modification]; other site 441770006580 aspartate aminotransferase; Provisional; Region: PRK05764 441770006581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770006582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770006583 homodimer interface [polypeptide binding]; other site 441770006584 catalytic residue [active] 441770006585 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 441770006586 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 441770006587 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 441770006588 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 441770006589 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 441770006590 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441770006591 Zn2+ binding site [ion binding]; other site 441770006592 Mg2+ binding site [ion binding]; other site 441770006593 recombinase A; Provisional; Region: recA; PRK09354 441770006594 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 441770006595 hexamer interface [polypeptide binding]; other site 441770006596 Walker A motif; other site 441770006597 ATP binding site [chemical binding]; other site 441770006598 Walker B motif; other site 441770006599 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 441770006600 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 441770006601 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 441770006602 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 441770006603 Tetraspanin family; Region: Tetraspannin; pfam00335 441770006604 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 441770006605 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 441770006606 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 441770006607 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 441770006608 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 441770006609 active site 441770006610 aspartate kinase I; Reviewed; Region: PRK08210 441770006611 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 441770006612 nucleotide binding site [chemical binding]; other site 441770006613 substrate binding site [chemical binding]; other site 441770006614 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 441770006615 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 441770006616 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 441770006617 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 441770006618 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 441770006619 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 441770006620 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 441770006621 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 441770006622 RNase E interface [polypeptide binding]; other site 441770006623 trimer interface [polypeptide binding]; other site 441770006624 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 441770006625 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 441770006626 RNase E interface [polypeptide binding]; other site 441770006627 trimer interface [polypeptide binding]; other site 441770006628 active site 441770006629 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 441770006630 putative nucleic acid binding region [nucleotide binding]; other site 441770006631 G-X-X-G motif; other site 441770006632 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 441770006633 RNA binding site [nucleotide binding]; other site 441770006634 domain interface; other site 441770006635 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 441770006636 16S/18S rRNA binding site [nucleotide binding]; other site 441770006637 S13e-L30e interaction site [polypeptide binding]; other site 441770006638 25S rRNA binding site [nucleotide binding]; other site 441770006639 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 441770006640 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 441770006641 active site 441770006642 Riboflavin kinase; Region: Flavokinase; pfam01687 441770006643 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 441770006644 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 441770006645 RNA binding site [nucleotide binding]; other site 441770006646 active site 441770006647 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 441770006648 DHH family; Region: DHH; pfam01368 441770006649 DHHA1 domain; Region: DHHA1; pfam02272 441770006650 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 441770006651 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 441770006652 translation initiation factor IF-2; Region: IF-2; TIGR00487 441770006653 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 441770006654 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 441770006655 G1 box; other site 441770006656 putative GEF interaction site [polypeptide binding]; other site 441770006657 GTP/Mg2+ binding site [chemical binding]; other site 441770006658 Switch I region; other site 441770006659 G2 box; other site 441770006660 G3 box; other site 441770006661 Switch II region; other site 441770006662 G4 box; other site 441770006663 G5 box; other site 441770006664 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 441770006665 Translation-initiation factor 2; Region: IF-2; pfam11987 441770006666 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 441770006667 ribosomal protein L7Ae family protein; Provisional; Region: PRK05583 441770006668 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 441770006669 putative RNA binding cleft [nucleotide binding]; other site 441770006670 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 441770006671 NusA N-terminal domain; Region: NusA_N; pfam08529 441770006672 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 441770006673 RNA binding site [nucleotide binding]; other site 441770006674 homodimer interface [polypeptide binding]; other site 441770006675 NusA-like KH domain; Region: KH_5; pfam13184 441770006676 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 441770006677 G-X-X-G motif; other site 441770006678 Sm and related proteins; Region: Sm_like; cl00259 441770006679 ribosome maturation protein RimP; Reviewed; Region: PRK00092 441770006680 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 441770006681 putative oligomer interface [polypeptide binding]; other site 441770006682 putative RNA binding site [nucleotide binding]; other site 441770006683 DNA polymerase III PolC; Validated; Region: polC; PRK00448 441770006684 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 441770006685 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 441770006686 generic binding surface II; other site 441770006687 generic binding surface I; other site 441770006688 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 441770006689 active site 441770006690 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 441770006691 active site 441770006692 catalytic site [active] 441770006693 substrate binding site [chemical binding]; other site 441770006694 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 441770006695 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 441770006696 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 441770006697 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 441770006698 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 441770006699 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 441770006700 active site 441770006701 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 441770006702 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 441770006703 putative substrate binding region [chemical binding]; other site 441770006704 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 441770006705 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 441770006706 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 441770006707 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 441770006708 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 441770006709 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 441770006710 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 441770006711 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 441770006712 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 441770006713 catalytic residue [active] 441770006714 putative FPP diphosphate binding site; other site 441770006715 putative FPP binding hydrophobic cleft; other site 441770006716 dimer interface [polypeptide binding]; other site 441770006717 putative IPP diphosphate binding site; other site 441770006718 ribosome recycling factor; Reviewed; Region: frr; PRK00083 441770006719 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 441770006720 hinge region; other site 441770006721 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 441770006722 putative nucleotide binding site [chemical binding]; other site 441770006723 uridine monophosphate binding site [chemical binding]; other site 441770006724 homohexameric interface [polypeptide binding]; other site 441770006725 elongation factor Ts; Provisional; Region: tsf; PRK09377 441770006726 UBA/TS-N domain; Region: UBA; pfam00627 441770006727 Elongation factor TS; Region: EF_TS; pfam00889 441770006728 Elongation factor TS; Region: EF_TS; pfam00889 441770006729 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 441770006730 rRNA interaction site [nucleotide binding]; other site 441770006731 S8 interaction site; other site 441770006732 putative laminin-1 binding site; other site 441770006733 transcriptional repressor CodY; Validated; Region: PRK04158 441770006734 CodY GAF-like domain; Region: CodY; pfam06018 441770006735 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 441770006736 DNA topoisomerase I; Validated; Region: PRK05582 441770006737 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 441770006738 active site 441770006739 interdomain interaction site; other site 441770006740 putative metal-binding site [ion binding]; other site 441770006741 nucleotide binding site [chemical binding]; other site 441770006742 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 441770006743 domain I; other site 441770006744 DNA binding groove [nucleotide binding] 441770006745 phosphate binding site [ion binding]; other site 441770006746 domain II; other site 441770006747 domain III; other site 441770006748 nucleotide binding site [chemical binding]; other site 441770006749 catalytic site [active] 441770006750 domain IV; other site 441770006751 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 441770006752 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 441770006753 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 441770006754 DNA protecting protein DprA; Region: dprA; TIGR00732 441770006755 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 441770006756 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 441770006757 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 441770006758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770006759 Walker A motif; other site 441770006760 ATP binding site [chemical binding]; other site 441770006761 Walker B motif; other site 441770006762 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 441770006763 hypothetical protein; Reviewed; Region: PRK12497 441770006764 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 441770006765 RNA/DNA hybrid binding site [nucleotide binding]; other site 441770006766 active site 441770006767 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 441770006768 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 441770006769 GTP/Mg2+ binding site [chemical binding]; other site 441770006770 G4 box; other site 441770006771 G5 box; other site 441770006772 G1 box; other site 441770006773 Switch I region; other site 441770006774 G2 box; other site 441770006775 G3 box; other site 441770006776 Switch II region; other site 441770006777 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 441770006778 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 441770006779 Catalytic site [active] 441770006780 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 441770006781 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 441770006782 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 441770006783 RimM N-terminal domain; Region: RimM; pfam01782 441770006784 PRC-barrel domain; Region: PRC; pfam05239 441770006785 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 441770006786 hypothetical protein; Provisional; Region: PRK00468 441770006787 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 441770006788 signal recognition particle protein; Provisional; Region: PRK10867 441770006789 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 441770006790 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 441770006791 P loop; other site 441770006792 GTP binding site [chemical binding]; other site 441770006793 Signal peptide binding domain; Region: SRP_SPB; pfam02978 441770006794 putative DNA-binding protein; Validated; Region: PRK00118 441770006795 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 441770006796 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 441770006797 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 441770006798 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441770006799 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 441770006800 AAA domain; Region: AAA_23; pfam13476 441770006801 Walker A/P-loop; other site 441770006802 ATP binding site [chemical binding]; other site 441770006803 Q-loop/lid; other site 441770006804 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 441770006805 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 441770006806 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 441770006807 Q-loop/lid; other site 441770006808 ABC transporter signature motif; other site 441770006809 Walker B; other site 441770006810 D-loop; other site 441770006811 H-loop/switch region; other site 441770006812 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 441770006813 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770006814 FeS/SAM binding site; other site 441770006815 ribonuclease III; Reviewed; Region: rnc; PRK00102 441770006816 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 441770006817 dimerization interface [polypeptide binding]; other site 441770006818 active site 441770006819 metal binding site [ion binding]; metal-binding site 441770006820 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 441770006821 dsRNA binding site [nucleotide binding]; other site 441770006822 acyl carrier protein; Provisional; Region: acpP; PRK00982 441770006823 putative phosphate acyltransferase; Provisional; Region: PRK05331 441770006824 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 441770006825 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 441770006826 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 441770006827 propionate/acetate kinase; Provisional; Region: PRK12379 441770006828 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 441770006829 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441770006830 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 441770006831 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 441770006832 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441770006833 Cache domain; Region: Cache_1; pfam02743 441770006834 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441770006835 dimerization interface [polypeptide binding]; other site 441770006836 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441770006837 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770006838 dimer interface [polypeptide binding]; other site 441770006839 putative CheW interface [polypeptide binding]; other site 441770006840 Uncharacterized conserved protein [Function unknown]; Region: COG1915 441770006841 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528 441770006842 Uncharacterized conserved protein [Function unknown]; Region: COG1915 441770006843 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 441770006844 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441770006845 proline racemase; Provisional; Region: PRK13969 441770006846 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 441770006847 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 441770006848 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 441770006849 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 441770006850 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 441770006851 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 441770006852 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 441770006853 SLBB domain; Region: SLBB; pfam10531 441770006854 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 441770006855 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 441770006856 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 441770006857 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441770006858 putative active site [active] 441770006859 heme pocket [chemical binding]; other site 441770006860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770006861 Walker A motif; other site 441770006862 ATP binding site [chemical binding]; other site 441770006863 Walker B motif; other site 441770006864 arginine finger; other site 441770006865 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441770006866 hypothetical protein; Provisional; Region: PRK13670 441770006867 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 441770006868 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 441770006869 Nucleoside recognition; Region: Gate; pfam07670 441770006870 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 441770006871 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 441770006872 active site 441770006873 (T/H)XGH motif; other site 441770006874 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 441770006875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770006876 S-adenosylmethionine binding site [chemical binding]; other site 441770006877 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 441770006878 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 441770006879 ssDNA binding site; other site 441770006880 generic binding surface II; other site 441770006881 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441770006882 ATP binding site [chemical binding]; other site 441770006883 putative Mg++ binding site [ion binding]; other site 441770006884 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441770006885 nucleotide binding region [chemical binding]; other site 441770006886 ATP-binding site [chemical binding]; other site 441770006887 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 441770006888 DAK2 domain; Region: Dak2; pfam02734 441770006889 Asp23 family; Region: Asp23; pfam03780 441770006890 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 441770006891 Thiamine pyrophosphokinase; Region: TPK; cd07995 441770006892 active site 441770006893 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 441770006894 dimerization interface [polypeptide binding]; other site 441770006895 thiamine binding site [chemical binding]; other site 441770006896 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 441770006897 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 441770006898 substrate binding site [chemical binding]; other site 441770006899 hexamer interface [polypeptide binding]; other site 441770006900 metal binding site [ion binding]; metal-binding site 441770006901 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 441770006902 GTPase RsgA; Reviewed; Region: PRK00098 441770006903 RNA binding site [nucleotide binding]; other site 441770006904 homodimer interface [polypeptide binding]; other site 441770006905 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 441770006906 GTPase/Zn-binding domain interface [polypeptide binding]; other site 441770006907 GTP/Mg2+ binding site [chemical binding]; other site 441770006908 G4 box; other site 441770006909 G5 box; other site 441770006910 G1 box; other site 441770006911 Switch I region; other site 441770006912 G2 box; other site 441770006913 G3 box; other site 441770006914 Switch II region; other site 441770006915 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 441770006916 Catalytic domain of Protein Kinases; Region: PKc; cd00180 441770006917 active site 441770006918 ATP binding site [chemical binding]; other site 441770006919 substrate binding site [chemical binding]; other site 441770006920 activation loop (A-loop); other site 441770006921 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 441770006922 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 441770006923 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 441770006924 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 441770006925 active site 441770006926 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 441770006927 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770006928 FeS/SAM binding site; other site 441770006929 16S rRNA methyltransferase B; Provisional; Region: PRK14902 441770006930 NusB family; Region: NusB; pfam01029 441770006931 putative RNA binding site [nucleotide binding]; other site 441770006932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770006933 S-adenosylmethionine binding site [chemical binding]; other site 441770006934 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 441770006935 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 441770006936 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 441770006937 putative active site [active] 441770006938 substrate binding site [chemical binding]; other site 441770006939 putative cosubstrate binding site; other site 441770006940 catalytic site [active] 441770006941 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 441770006942 substrate binding site [chemical binding]; other site 441770006943 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 441770006944 active site 441770006945 catalytic residues [active] 441770006946 metal binding site [ion binding]; metal-binding site 441770006947 primosome assembly protein PriA; Validated; Region: PRK05580 441770006948 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441770006949 ATP binding site [chemical binding]; other site 441770006950 putative Mg++ binding site [ion binding]; other site 441770006951 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441770006952 nucleotide binding region [chemical binding]; other site 441770006953 ATP-binding site [chemical binding]; other site 441770006954 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 441770006955 Flavoprotein; Region: Flavoprotein; pfam02441 441770006956 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 441770006957 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 441770006958 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 441770006959 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 441770006960 catalytic site [active] 441770006961 G-X2-G-X-G-K; other site 441770006962 hypothetical protein; Provisional; Region: PRK04323 441770006963 hypothetical protein; Provisional; Region: PRK11820 441770006964 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 441770006965 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 441770006966 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 441770006967 active site 441770006968 homotetramer interface [polypeptide binding]; other site 441770006969 homodimer interface [polypeptide binding]; other site 441770006970 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 441770006971 sequence-specific DNA binding site [nucleotide binding]; other site 441770006972 salt bridge; other site 441770006973 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 441770006974 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 441770006975 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 441770006976 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 441770006977 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 441770006978 GTP-binding protein Der; Reviewed; Region: PRK00093 441770006979 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 441770006980 G1 box; other site 441770006981 GTP/Mg2+ binding site [chemical binding]; other site 441770006982 Switch I region; other site 441770006983 G2 box; other site 441770006984 Switch II region; other site 441770006985 G3 box; other site 441770006986 G4 box; other site 441770006987 G5 box; other site 441770006988 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 441770006989 G1 box; other site 441770006990 GTP/Mg2+ binding site [chemical binding]; other site 441770006991 Switch I region; other site 441770006992 G2 box; other site 441770006993 G3 box; other site 441770006994 Switch II region; other site 441770006995 G4 box; other site 441770006996 G5 box; other site 441770006997 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 441770006998 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 441770006999 Protein of unknown function (DUF512); Region: DUF512; pfam04459 441770007000 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 441770007001 PhoU domain; Region: PhoU; pfam01895 441770007002 PhoU domain; Region: PhoU; pfam01895 441770007003 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 441770007004 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 441770007005 Walker A/P-loop; other site 441770007006 ATP binding site [chemical binding]; other site 441770007007 Q-loop/lid; other site 441770007008 ABC transporter signature motif; other site 441770007009 Walker B; other site 441770007010 D-loop; other site 441770007011 H-loop/switch region; other site 441770007012 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 441770007013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770007014 dimer interface [polypeptide binding]; other site 441770007015 conserved gate region; other site 441770007016 putative PBP binding loops; other site 441770007017 ABC-ATPase subunit interface; other site 441770007018 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 441770007019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770007020 dimer interface [polypeptide binding]; other site 441770007021 conserved gate region; other site 441770007022 putative PBP binding loops; other site 441770007023 ABC-ATPase subunit interface; other site 441770007024 PBP superfamily domain; Region: PBP_like_2; cl17296 441770007025 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441770007026 dimerization interface [polypeptide binding]; other site 441770007027 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 441770007028 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441770007029 putative active site [active] 441770007030 heme pocket [chemical binding]; other site 441770007031 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770007032 dimer interface [polypeptide binding]; other site 441770007033 phosphorylation site [posttranslational modification] 441770007034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770007035 ATP binding site [chemical binding]; other site 441770007036 Mg2+ binding site [ion binding]; other site 441770007037 G-X-G motif; other site 441770007038 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770007039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770007040 active site 441770007041 phosphorylation site [posttranslational modification] 441770007042 intermolecular recognition site; other site 441770007043 dimerization interface [polypeptide binding]; other site 441770007044 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770007045 DNA binding site [nucleotide binding] 441770007046 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 441770007047 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 441770007048 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 441770007049 ATP cone domain; Region: ATP-cone; pfam03477 441770007050 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 441770007051 sporulation sigma factor SigG; Reviewed; Region: PRK08215 441770007052 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441770007053 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 441770007054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441770007055 DNA binding residues [nucleotide binding] 441770007056 sporulation sigma factor SigE; Reviewed; Region: PRK08301 441770007057 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441770007058 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441770007059 DNA binding residues [nucleotide binding] 441770007060 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 441770007061 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 441770007062 cell division protein FtsZ; Validated; Region: PRK09330 441770007063 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 441770007064 nucleotide binding site [chemical binding]; other site 441770007065 SulA interaction site; other site 441770007066 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 441770007067 Cell division protein FtsA; Region: FtsA; smart00842 441770007068 Cell division protein FtsA; Region: FtsA; pfam14450 441770007069 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 441770007070 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 441770007071 DXD motif; other site 441770007072 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 441770007073 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 441770007074 Walker A motif; other site 441770007075 ATP binding site [chemical binding]; other site 441770007076 Walker B motif; other site 441770007077 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 441770007078 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 441770007079 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 441770007080 shikimate binding site; other site 441770007081 NAD(P) binding site [chemical binding]; other site 441770007082 DNA binding residues [nucleotide binding] 441770007083 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 441770007084 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441770007085 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770007086 non-specific DNA binding site [nucleotide binding]; other site 441770007087 salt bridge; other site 441770007088 sequence-specific DNA binding site [nucleotide binding]; other site 441770007089 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770007090 non-specific DNA binding site [nucleotide binding]; other site 441770007091 salt bridge; other site 441770007092 sequence-specific DNA binding site [nucleotide binding]; other site 441770007093 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 441770007094 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 441770007095 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 441770007096 Walker A motif; other site 441770007097 ATP binding site [chemical binding]; other site 441770007098 Walker B motif; other site 441770007099 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770007100 non-specific DNA binding site [nucleotide binding]; other site 441770007101 salt bridge; other site 441770007102 sequence-specific DNA binding site [nucleotide binding]; other site 441770007103 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 441770007104 amidase catalytic site [active] 441770007105 Zn binding residues [ion binding]; other site 441770007106 substrate binding site [chemical binding]; other site 441770007107 Haemolysin XhlA; Region: XhlA; pfam10779 441770007108 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 441770007109 Phage tail protein; Region: Sipho_tail; pfam05709 441770007110 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 441770007111 Transmembrane protein; Region: Macoilin; pfam09726 441770007112 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 441770007113 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 441770007114 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 441770007115 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 441770007116 oligomerization interface [polypeptide binding]; other site 441770007117 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 441770007118 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 441770007119 Phage capsid family; Region: Phage_capsid; pfam05065 441770007120 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 441770007121 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 441770007122 oligomer interface [polypeptide binding]; other site 441770007123 active site residues [active] 441770007124 Phage portal protein; Region: Phage_portal; pfam04860 441770007125 Phage-related protein [Function unknown]; Region: COG4695; cl01923 441770007126 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 441770007127 Phage terminase, small subunit; Region: Terminase_4; pfam05119 441770007128 ParA/MinD ATPase like; Region: ParA; pfam10609 441770007129 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 441770007130 Int/Topo IB signature motif; other site 441770007131 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 441770007132 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441770007133 active site 441770007134 DNA binding site [nucleotide binding] 441770007135 Int/Topo IB signature motif; other site 441770007136 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 441770007137 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 441770007138 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 441770007139 cofactor binding site; other site 441770007140 DNA binding site [nucleotide binding] 441770007141 substrate interaction site [chemical binding]; other site 441770007142 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u5; cd11542 441770007143 metal binding site [ion binding]; metal-binding site 441770007144 Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417 441770007145 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 441770007146 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 441770007147 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 441770007148 ORF6N domain; Region: ORF6N; pfam10543 441770007149 ORF6C domain; Region: ORF6C; pfam10552 441770007150 K-Cl cotransporter; Region: 2a30; TIGR00930 441770007151 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770007152 non-specific DNA binding site [nucleotide binding]; other site 441770007153 salt bridge; other site 441770007154 sequence-specific DNA binding site [nucleotide binding]; other site 441770007155 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770007156 non-specific DNA binding site [nucleotide binding]; other site 441770007157 salt bridge; other site 441770007158 sequence-specific DNA binding site [nucleotide binding]; other site 441770007159 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 441770007160 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 441770007161 catalytic residues [active] 441770007162 catalytic nucleophile [active] 441770007163 Recombinase; Region: Recombinase; pfam07508 441770007164 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 441770007165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441770007166 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 441770007167 conserved domain; Region: TIGR02271 441770007168 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 441770007169 RecT family; Region: RecT; pfam03837 441770007170 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770007171 non-specific DNA binding site [nucleotide binding]; other site 441770007172 salt bridge; other site 441770007173 sequence-specific DNA binding site [nucleotide binding]; other site 441770007174 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441770007175 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 441770007176 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 441770007177 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 441770007178 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 441770007179 ATP-binding site [chemical binding]; other site 441770007180 Sugar specificity; other site 441770007181 Pyrimidine base specificity; other site 441770007182 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 441770007183 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 441770007184 Peptidase family U32; Region: Peptidase_U32; pfam01136 441770007185 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 441770007186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770007187 S-adenosylmethionine binding site [chemical binding]; other site 441770007188 YceG-like family; Region: YceG; pfam02618 441770007189 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 441770007190 dimerization interface [polypeptide binding]; other site 441770007191 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 441770007192 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 441770007193 G1 box; other site 441770007194 putative GEF interaction site [polypeptide binding]; other site 441770007195 GTP/Mg2+ binding site [chemical binding]; other site 441770007196 Switch I region; other site 441770007197 G2 box; other site 441770007198 G3 box; other site 441770007199 Switch II region; other site 441770007200 G4 box; other site 441770007201 G5 box; other site 441770007202 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 441770007203 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 441770007204 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 441770007205 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441770007206 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 441770007207 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 441770007208 metal binding site 2 [ion binding]; metal-binding site 441770007209 putative DNA binding helix; other site 441770007210 metal binding site 1 [ion binding]; metal-binding site 441770007211 dimer interface [polypeptide binding]; other site 441770007212 structural Zn2+ binding site [ion binding]; other site 441770007213 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 441770007214 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 441770007215 hypothetical protein; Provisional; Region: PRK05473 441770007216 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 441770007217 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 441770007218 motif 1; other site 441770007219 active site 441770007220 motif 2; other site 441770007221 motif 3; other site 441770007222 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 441770007223 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 441770007224 Domain of unknown function DUF20; Region: UPF0118; pfam01594 441770007225 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 441770007226 PRC-barrel domain; Region: PRC; pfam05239 441770007227 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 441770007228 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 441770007229 trimerization site [polypeptide binding]; other site 441770007230 active site 441770007231 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 441770007232 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 441770007233 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441770007234 catalytic residue [active] 441770007235 Transcriptional regulator; Region: Rrf2; cl17282 441770007236 Rrf2 family protein; Region: rrf2_super; TIGR00738 441770007237 recombination factor protein RarA; Reviewed; Region: PRK13342 441770007238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770007239 Walker A motif; other site 441770007240 ATP binding site [chemical binding]; other site 441770007241 Walker B motif; other site 441770007242 arginine finger; other site 441770007243 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 441770007244 histidinol-phosphatase; Provisional; Region: PRK05588 441770007245 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 441770007246 active site 441770007247 Predicted permeases [General function prediction only]; Region: COG0679 441770007248 EDD domain protein, DegV family; Region: DegV; TIGR00762 441770007249 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 441770007250 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 441770007251 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 441770007252 CPxP motif; other site 441770007253 DsrE/DsrF-like family; Region: DrsE; pfam02635 441770007254 ornithine cyclodeaminase; Validated; Region: PRK08618 441770007255 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 441770007256 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 441770007257 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 441770007258 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 441770007259 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 441770007260 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 441770007261 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 441770007262 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 441770007263 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 441770007264 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 441770007265 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 441770007266 dimerization interface [polypeptide binding]; other site 441770007267 ATP binding site [chemical binding]; other site 441770007268 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 441770007269 dimerization interface [polypeptide binding]; other site 441770007270 ATP binding site [chemical binding]; other site 441770007271 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 441770007272 putative active site [active] 441770007273 catalytic triad [active] 441770007274 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441770007275 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 441770007276 phosphoenolpyruvate synthase; Validated; Region: PRK06241 441770007277 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 441770007278 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 441770007279 Phosphopantetheine attachment site; Region: PP-binding; cl09936 441770007280 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 441770007281 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 441770007282 active site 441770007283 AMP binding site [chemical binding]; other site 441770007284 acyl-activating enzyme (AAE) consensus motif; other site 441770007285 CoA binding site [chemical binding]; other site 441770007286 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 441770007287 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 441770007288 dimer interface [polypeptide binding]; other site 441770007289 active site 441770007290 CoA binding pocket [chemical binding]; other site 441770007291 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 441770007292 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 441770007293 AMP-binding enzyme; Region: AMP-binding; pfam00501 441770007294 acyl-activating enzyme (AAE) consensus motif; other site 441770007295 AMP binding site [chemical binding]; other site 441770007296 active site 441770007297 CoA binding site [chemical binding]; other site 441770007298 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 441770007299 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 441770007300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770007301 Coenzyme A binding pocket [chemical binding]; other site 441770007302 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 441770007303 Ligand Binding Site [chemical binding]; other site 441770007304 hypothetical protein; Validated; Region: PRK07080 441770007305 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 441770007306 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 441770007307 ornithine carbamoyltransferase; Provisional; Region: PRK04284 441770007308 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 441770007309 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 441770007310 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 441770007311 carbamate kinase; Reviewed; Region: PRK12686 441770007312 putative substrate binding site [chemical binding]; other site 441770007313 nucleotide binding site [chemical binding]; other site 441770007314 nucleotide binding site [chemical binding]; other site 441770007315 homodimer interface [polypeptide binding]; other site 441770007316 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 441770007317 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 441770007318 dimer interface [polypeptide binding]; other site 441770007319 active site 441770007320 glycine-pyridoxal phosphate binding site [chemical binding]; other site 441770007321 folate binding site [chemical binding]; other site 441770007322 Uncharacterized conserved protein [Function unknown]; Region: COG2966 441770007323 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 441770007324 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 441770007325 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 441770007326 putative homodimer interface [polypeptide binding]; other site 441770007327 putative homotetramer interface [polypeptide binding]; other site 441770007328 putative allosteric switch controlling residues; other site 441770007329 putative metal binding site [ion binding]; other site 441770007330 putative homodimer-homodimer interface [polypeptide binding]; other site 441770007331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441770007332 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 441770007333 active site 441770007334 motif I; other site 441770007335 motif II; other site 441770007336 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 441770007337 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 441770007338 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441770007339 active site 441770007340 nucleotide binding site [chemical binding]; other site 441770007341 HIGH motif; other site 441770007342 KMSKS motif; other site 441770007343 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 441770007344 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 441770007345 NAD(P) binding site [chemical binding]; other site 441770007346 substrate binding site [chemical binding]; other site 441770007347 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 441770007348 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 441770007349 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 441770007350 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 441770007351 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 441770007352 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 441770007353 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 441770007354 oligomer interface [polypeptide binding]; other site 441770007355 putative active site [active] 441770007356 metal binding site [ion binding]; metal-binding site 441770007357 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 441770007358 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 441770007359 oligomer interface [polypeptide binding]; other site 441770007360 metal binding site [ion binding]; metal-binding site 441770007361 metal binding site [ion binding]; metal-binding site 441770007362 putative Cl binding site [ion binding]; other site 441770007363 aspartate ring; other site 441770007364 basic sphincter; other site 441770007365 hydrophobic gate; other site 441770007366 periplasmic entrance; other site 441770007367 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 441770007368 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 441770007369 HPr kinase/phosphorylase; Provisional; Region: PRK05428 441770007370 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 441770007371 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 441770007372 Hpr binding site; other site 441770007373 active site 441770007374 homohexamer subunit interaction site [polypeptide binding]; other site 441770007375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 441770007376 Uncharacterized conserved protein [Function unknown]; Region: COG0398 441770007377 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 441770007378 Uncharacterized conserved protein [Function unknown]; Region: COG0398 441770007379 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 441770007380 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 441770007381 Cysteine-rich domain; Region: CCG; pfam02754 441770007382 Cysteine-rich domain; Region: CCG; pfam02754 441770007383 Phosphotransferase enzyme family; Region: APH; pfam01636 441770007384 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 441770007385 active site 441770007386 ATP binding site [chemical binding]; other site 441770007387 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 441770007388 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 441770007389 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 441770007390 Probable Catalytic site; other site 441770007391 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 441770007392 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 441770007393 active site residue [active] 441770007394 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 441770007395 active site residue [active] 441770007396 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 441770007397 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 441770007398 putative active site [active] 441770007399 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 441770007400 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 441770007401 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441770007402 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 441770007403 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 441770007404 active site 441770007405 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 441770007406 active site 441770007407 catalytic residues [active] 441770007408 metal binding site [ion binding]; metal-binding site 441770007409 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 441770007410 V-type ATP synthase subunit B; Provisional; Region: PRK04196 441770007411 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 441770007412 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 441770007413 Walker A motif homologous position; other site 441770007414 Walker B motif; other site 441770007415 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 441770007416 V-type ATP synthase subunit A; Provisional; Region: PRK04192 441770007417 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 441770007418 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 441770007419 Walker A motif/ATP binding site; other site 441770007420 Walker B motif; other site 441770007421 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 441770007422 V-type ATP synthase subunit F; Provisional; Region: PRK01395 441770007423 V-type ATP synthase subunit C; Provisional; Region: PRK01198 441770007424 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 441770007425 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 441770007426 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 441770007427 V-type ATP synthase subunit K; Validated; Region: PRK06558 441770007428 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 441770007429 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 441770007430 V-type ATP synthase subunit I; Validated; Region: PRK05771 441770007431 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 441770007432 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 441770007433 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 441770007434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 441770007435 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 441770007436 Zn binding site [ion binding]; other site 441770007437 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 441770007438 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 441770007439 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 441770007440 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441770007441 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 441770007442 Soluble P-type ATPase [General function prediction only]; Region: COG4087 441770007443 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 441770007444 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 441770007445 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 441770007446 DRTGG domain; Region: DRTGG; pfam07085 441770007447 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 441770007448 DHH family; Region: DHH; pfam01368 441770007449 DHHA2 domain; Region: DHHA2; pfam02833 441770007450 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 441770007451 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 441770007452 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 441770007453 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 441770007454 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 441770007455 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 441770007456 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 441770007457 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441770007458 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 441770007459 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441770007460 DNA binding residues [nucleotide binding] 441770007461 Flagellar protein YcgR; Region: YcgR_2; pfam12945 441770007462 PilZ domain; Region: PilZ; pfam07238 441770007463 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 441770007464 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 441770007465 P-loop; other site 441770007466 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 441770007467 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441770007468 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 441770007469 FHIPEP family; Region: FHIPEP; pfam00771 441770007470 bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772 441770007471 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 441770007472 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 441770007473 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 441770007474 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 441770007475 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 441770007476 flagellar motor protein MotS; Reviewed; Region: PRK06925 441770007477 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 441770007478 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 441770007479 ligand binding site [chemical binding]; other site 441770007480 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 441770007481 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 441770007482 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 441770007483 Flagellar protein (FlbD); Region: FlbD; pfam06289 441770007484 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 441770007485 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 441770007486 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 441770007487 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 441770007488 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 441770007489 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 441770007490 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 441770007491 Flagellar FliJ protein; Region: FliJ; pfam02050 441770007492 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 441770007493 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 441770007494 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 441770007495 Walker A motif/ATP binding site; other site 441770007496 Walker B motif; other site 441770007497 Flagellar assembly protein FliH; Region: FliH; pfam02108 441770007498 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 441770007499 FliG C-terminal domain; Region: FliG_C; pfam01706 441770007500 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 441770007501 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 441770007502 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 441770007503 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 441770007504 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12630 441770007505 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 441770007506 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 441770007507 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623 441770007508 flagellin; Provisional; Region: PRK12804 441770007509 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 441770007510 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 441770007511 argininosuccinate lyase; Provisional; Region: PRK00855 441770007512 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 441770007513 active sites [active] 441770007514 tetramer interface [polypeptide binding]; other site 441770007515 argininosuccinate synthase; Provisional; Region: PRK13820 441770007516 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 441770007517 ANP binding site [chemical binding]; other site 441770007518 Substrate Binding Site II [chemical binding]; other site 441770007519 Substrate Binding Site I [chemical binding]; other site 441770007520 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 441770007521 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 441770007522 putative active site [active] 441770007523 catalytic site [active] 441770007524 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 441770007525 putative active site [active] 441770007526 catalytic site [active] 441770007527 Predicted membrane protein [Function unknown]; Region: COG4129 441770007528 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 441770007529 Predicted integral membrane protein [Function unknown]; Region: COG5652 441770007530 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 441770007531 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441770007532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441770007533 NAD(P) binding site [chemical binding]; other site 441770007534 active site 441770007535 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 441770007536 NeuB family; Region: NeuB; pfam03102 441770007537 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 441770007538 NeuB binding interface [polypeptide binding]; other site 441770007539 putative substrate binding site [chemical binding]; other site 441770007540 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 441770007541 ligand binding site; other site 441770007542 tetramer interface; other site 441770007543 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 441770007544 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 441770007545 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 441770007546 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 441770007547 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 441770007548 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 441770007549 UDP-galactopyranose mutase; Region: GLF; pfam03275 441770007550 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 441770007551 Bacterial sugar transferase; Region: Bac_transf; pfam02397 441770007552 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 441770007553 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441770007554 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 441770007555 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 441770007556 Chain length determinant protein; Region: Wzz; cl15801 441770007557 Transcriptional regulator [Transcription]; Region: LytR; COG1316 441770007558 Putative motility protein; Region: YjfB_motility; pfam14070 441770007559 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770007560 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441770007561 dimer interface [polypeptide binding]; other site 441770007562 putative CheW interface [polypeptide binding]; other site 441770007563 flagellin; Provisional; Region: PRK12804 441770007564 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 441770007565 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 441770007566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 441770007567 binding surface 441770007568 TPR motif; other site 441770007569 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 441770007570 catalytic triad [active] 441770007571 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 441770007572 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 441770007573 active site 441770007574 catalytic triad [active] 441770007575 oxyanion hole [active] 441770007576 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 441770007577 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 441770007578 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 441770007579 active site 441770007580 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441770007581 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441770007582 binding surface 441770007583 TPR motif; other site 441770007584 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 441770007585 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441770007586 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441770007587 glycosyltransferase, GG-Bacteroidales peptide system; Region: glyco_rSAM_CFB; TIGR04157 441770007588 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 441770007589 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 441770007590 Ligand Binding Site [chemical binding]; other site 441770007591 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 441770007592 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441770007593 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 441770007594 putative active site [active] 441770007595 putative catalytic site [active] 441770007596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770007597 S-adenosylmethionine binding site [chemical binding]; other site 441770007598 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 441770007599 glycosyltransferase, GG-Bacteroidales peptide system; Region: glyco_rSAM_CFB; TIGR04157 441770007600 Radical SAM superfamily; Region: Radical_SAM; pfam04055 441770007601 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770007602 FeS/SAM binding site; other site 441770007603 Cephalosporin hydroxylase; Region: CmcI; pfam04989 441770007604 Methyltransferase domain; Region: Methyltransf_23; pfam13489 441770007605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770007606 S-adenosylmethionine binding site [chemical binding]; other site 441770007607 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 441770007608 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441770007609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441770007610 NAD(P) binding site [chemical binding]; other site 441770007611 active site 441770007612 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 441770007613 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 441770007614 Methyltransferase domain; Region: Methyltransf_23; pfam13489 441770007615 Methyltransferase domain; Region: Methyltransf_12; pfam08242 441770007616 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 441770007617 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770007618 Radical SAM superfamily; Region: Radical_SAM; pfam04055 441770007619 FeS/SAM binding site; other site 441770007620 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 441770007621 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 441770007622 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 441770007623 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 441770007624 substrate binding site; other site 441770007625 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 441770007626 pseudaminic acid synthase; Region: PseI; TIGR03586 441770007627 NeuB family; Region: NeuB; pfam03102 441770007628 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 441770007629 NeuB binding interface [polypeptide binding]; other site 441770007630 putative substrate binding site [chemical binding]; other site 441770007631 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 441770007632 ligand binding site; other site 441770007633 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 441770007634 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441770007635 motif II; other site 441770007636 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 441770007637 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 441770007638 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441770007639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441770007640 NAD(P) binding site [chemical binding]; other site 441770007641 active site 441770007642 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 441770007643 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 441770007644 NAD(P) binding site [chemical binding]; other site 441770007645 homodimer interface [polypeptide binding]; other site 441770007646 substrate binding site [chemical binding]; other site 441770007647 active site 441770007648 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 441770007649 putative metal binding site; other site 441770007650 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 441770007651 TPR motif; other site 441770007652 binding surface 441770007653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441770007654 TPR motif; other site 441770007655 binding surface 441770007656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441770007657 binding surface 441770007658 TPR motif; other site 441770007659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 441770007660 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 441770007661 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 441770007662 putative metal binding site; other site 441770007663 TPR repeat; Region: TPR_11; pfam13414 441770007664 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441770007665 binding surface 441770007666 TPR motif; other site 441770007667 Tetratricopeptide repeat; Region: TPR_16; pfam13432 441770007668 flagellin; Provisional; Region: PRK12804 441770007669 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 441770007670 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 441770007671 flagellin; Provisional; Region: PRK12804 441770007672 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 441770007673 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 441770007674 Flagellar protein FliT; Region: FliT; pfam05400 441770007675 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 441770007676 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 441770007677 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 441770007678 FlaG protein; Region: FlaG; pfam03646 441770007679 carbon storage regulator; Provisional; Region: PRK01712 441770007680 flagellar assembly protein FliW; Provisional; Region: PRK13285 441770007681 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 441770007682 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 441770007683 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 441770007684 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 441770007685 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 441770007686 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 441770007687 FlgN protein; Region: FlgN; pfam05130 441770007688 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 441770007689 flagellar motor switch protein; Validated; Region: PRK08119 441770007690 CheC-like family; Region: CheC; pfam04509 441770007691 CheC-like family; Region: CheC; pfam04509 441770007692 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 441770007693 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 441770007694 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 441770007695 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 441770007696 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 441770007697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770007698 active site 441770007699 phosphorylation site [posttranslational modification] 441770007700 intermolecular recognition site; other site 441770007701 dimerization interface [polypeptide binding]; other site 441770007702 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 441770007703 CheC-like family; Region: CheC; pfam04509 441770007704 CheC-like family; Region: CheC; pfam04509 441770007705 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 441770007706 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 441770007707 putative binding surface; other site 441770007708 active site 441770007709 P2 response regulator binding domain; Region: P2; pfam07194 441770007710 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 441770007711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770007712 ATP binding site [chemical binding]; other site 441770007713 Mg2+ binding site [ion binding]; other site 441770007714 G-X-G motif; other site 441770007715 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 441770007716 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 441770007717 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 441770007718 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 441770007719 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 441770007720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770007721 active site 441770007722 phosphorylation site [posttranslational modification] 441770007723 intermolecular recognition site; other site 441770007724 dimerization interface [polypeptide binding]; other site 441770007725 CheB methylesterase; Region: CheB_methylest; pfam01339 441770007726 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13490 441770007727 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 441770007728 Protein of unknown function (DUF342); Region: DUF342; pfam03961 441770007729 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441770007730 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 441770007731 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441770007732 active site turn [active] 441770007733 phosphorylation site [posttranslational modification] 441770007734 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 441770007735 HPr interaction site; other site 441770007736 glycerol kinase (GK) interaction site [polypeptide binding]; other site 441770007737 active site 441770007738 phosphorylation site [posttranslational modification] 441770007739 transcriptional antiterminator BglG; Provisional; Region: PRK09772 441770007740 CAT RNA binding domain; Region: CAT_RBD; smart01061 441770007741 PRD domain; Region: PRD; pfam00874 441770007742 PRD domain; Region: PRD; pfam00874 441770007743 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 441770007744 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 441770007745 homodimer interface [polypeptide binding]; other site 441770007746 substrate-cofactor binding pocket; other site 441770007747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770007748 catalytic residue [active] 441770007749 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 441770007750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441770007751 motif II; other site 441770007752 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 441770007753 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 441770007754 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 441770007755 dimer interface [polypeptide binding]; other site 441770007756 PYR/PP interface [polypeptide binding]; other site 441770007757 TPP binding site [chemical binding]; other site 441770007758 substrate binding site [chemical binding]; other site 441770007759 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 441770007760 Domain of unknown function; Region: EKR; smart00890 441770007761 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 441770007762 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 441770007763 TPP-binding site [chemical binding]; other site 441770007764 dimer interface [polypeptide binding]; other site 441770007765 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 441770007766 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 441770007767 active site 441770007768 homodimer interface [polypeptide binding]; other site 441770007769 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770007770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770007771 dimer interface [polypeptide binding]; other site 441770007772 phosphorylation site [posttranslational modification] 441770007773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770007774 ATP binding site [chemical binding]; other site 441770007775 Mg2+ binding site [ion binding]; other site 441770007776 G-X-G motif; other site 441770007777 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 441770007778 DHH family; Region: DHH; pfam01368 441770007779 DHHA1 domain; Region: DHHA1; pfam02272 441770007780 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 441770007781 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 441770007782 AP (apurinic/apyrimidinic) site pocket; other site 441770007783 DNA interaction; other site 441770007784 Metal-binding active site; metal-binding site 441770007785 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 441770007786 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 441770007787 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 441770007788 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 441770007789 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 441770007790 Predicted membrane protein [Function unknown]; Region: COG2246 441770007791 GtrA-like protein; Region: GtrA; pfam04138 441770007792 DJ-1 family protein; Region: not_thiJ; TIGR01383 441770007793 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 441770007794 conserved cys residue [active] 441770007795 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 441770007796 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 441770007797 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 441770007798 CAP-like domain; other site 441770007799 active site 441770007800 primary dimer interface [polypeptide binding]; other site 441770007801 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441770007802 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 441770007803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770007804 ATP binding site [chemical binding]; other site 441770007805 Mg2+ binding site [ion binding]; other site 441770007806 G-X-G motif; other site 441770007807 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 441770007808 anchoring element; other site 441770007809 dimer interface [polypeptide binding]; other site 441770007810 ATP binding site [chemical binding]; other site 441770007811 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 441770007812 active site 441770007813 metal binding site [ion binding]; metal-binding site 441770007814 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 441770007815 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 441770007816 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 441770007817 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 441770007818 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 441770007819 NodB motif; other site 441770007820 active site 441770007821 catalytic site [active] 441770007822 Zn binding site [ion binding]; other site 441770007823 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 441770007824 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 441770007825 NAD binding site [chemical binding]; other site 441770007826 homodimer interface [polypeptide binding]; other site 441770007827 active site 441770007828 substrate binding site [chemical binding]; other site 441770007829 flavodoxin; Provisional; Region: PRK05568 441770007830 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 441770007831 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441770007832 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 441770007833 Cupin domain; Region: Cupin_2; cl17218 441770007834 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 441770007835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770007836 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 441770007837 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 441770007838 putative dimer interface [polypeptide binding]; other site 441770007839 catalytic triad [active] 441770007840 glycerol kinase; Provisional; Region: glpK; PRK00047 441770007841 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 441770007842 N- and C-terminal domain interface [polypeptide binding]; other site 441770007843 active site 441770007844 MgATP binding site [chemical binding]; other site 441770007845 catalytic site [active] 441770007846 metal binding site [ion binding]; metal-binding site 441770007847 glycerol binding site [chemical binding]; other site 441770007848 homotetramer interface [polypeptide binding]; other site 441770007849 homodimer interface [polypeptide binding]; other site 441770007850 FBP binding site [chemical binding]; other site 441770007851 protein IIAGlc interface [polypeptide binding]; other site 441770007852 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 441770007853 amphipathic channel; other site 441770007854 Asn-Pro-Ala signature motifs; other site 441770007855 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 441770007856 VanZ like family; Region: VanZ; pfam04892 441770007857 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441770007858 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441770007859 Walker A/P-loop; other site 441770007860 ATP binding site [chemical binding]; other site 441770007861 Q-loop/lid; other site 441770007862 ABC transporter signature motif; other site 441770007863 Walker B; other site 441770007864 D-loop; other site 441770007865 H-loop/switch region; other site 441770007866 Predicted transcriptional regulators [Transcription]; Region: COG1725 441770007867 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770007868 DNA-binding site [nucleotide binding]; DNA binding site 441770007869 VanZ like family; Region: VanZ; cl01971 441770007870 hybrid cluster protein; Provisional; Region: PRK05290 441770007871 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 441770007872 ACS interaction site; other site 441770007873 CODH interaction site; other site 441770007874 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 441770007875 hybrid metal cluster; other site 441770007876 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 441770007877 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 441770007878 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 441770007879 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 441770007880 Spore germination protein; Region: Spore_permease; pfam03845 441770007881 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 441770007882 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 441770007883 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 441770007884 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 441770007885 active site 441770007886 multimer interface [polypeptide binding]; other site 441770007887 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 441770007888 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 441770007889 NodB motif; other site 441770007890 active site 441770007891 catalytic site [active] 441770007892 Zn binding site [ion binding]; other site 441770007893 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 441770007894 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 441770007895 ATP binding site [chemical binding]; other site 441770007896 Mg++ binding site [ion binding]; other site 441770007897 motif III; other site 441770007898 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441770007899 nucleotide binding region [chemical binding]; other site 441770007900 ATP-binding site [chemical binding]; other site 441770007901 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 441770007902 RNA binding site [nucleotide binding]; other site 441770007903 Probable zinc-binding domain; Region: zf-trcl; pfam13451 441770007904 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770007905 dimer interface [polypeptide binding]; other site 441770007906 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 441770007907 putative CheW interface [polypeptide binding]; other site 441770007908 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 441770007909 Ligand Binding Site [chemical binding]; other site 441770007910 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 441770007911 4Fe-4S binding domain; Region: Fer4_5; pfam12801 441770007912 glutaminase; Provisional; Region: PRK00971 441770007913 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 441770007914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 441770007915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 441770007916 Cache domain; Region: Cache_1; pfam02743 441770007917 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441770007918 dimerization interface [polypeptide binding]; other site 441770007919 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770007920 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441770007921 dimer interface [polypeptide binding]; other site 441770007922 putative CheW interface [polypeptide binding]; other site 441770007923 TraX protein; Region: TraX; cl05434 441770007924 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 441770007925 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 441770007926 dimer interface [polypeptide binding]; other site 441770007927 putative radical transfer pathway; other site 441770007928 diiron center [ion binding]; other site 441770007929 tyrosyl radical; other site 441770007930 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088 441770007931 ATP cone domain; Region: ATP-cone; pfam03477 441770007932 Class I ribonucleotide reductase; Region: RNR_I; cd01679 441770007933 active site 441770007934 dimer interface [polypeptide binding]; other site 441770007935 catalytic residues [active] 441770007936 effector binding site; other site 441770007937 R2 peptide binding site; other site 441770007938 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 441770007939 Putative amidase domain; Region: Amidase_6; pfam12671 441770007940 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 441770007941 DNA polymerase IV; Provisional; Region: PRK14133 441770007942 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 441770007943 active site 441770007944 DNA binding site [nucleotide binding] 441770007945 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 441770007946 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 441770007947 homodimer interface [polypeptide binding]; other site 441770007948 active site 441770007949 FMN binding site [chemical binding]; other site 441770007950 substrate binding site [chemical binding]; other site 441770007951 4Fe-4S binding domain; Region: Fer4; pfam00037 441770007952 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 441770007953 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 441770007954 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 441770007955 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441770007956 active site 441770007957 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 441770007958 Uncharacterized conserved protein [Function unknown]; Region: COG1434 441770007959 putative active site [active] 441770007960 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441770007961 MarR family; Region: MarR_2; pfam12802 441770007962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770007963 Walker A/P-loop; other site 441770007964 ATP binding site [chemical binding]; other site 441770007965 Q-loop/lid; other site 441770007966 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 441770007967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770007968 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 441770007969 Walker A/P-loop; other site 441770007970 ATP binding site [chemical binding]; other site 441770007971 Q-loop/lid; other site 441770007972 ABC transporter signature motif; other site 441770007973 Walker B; other site 441770007974 D-loop; other site 441770007975 H-loop/switch region; other site 441770007976 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 441770007977 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 441770007978 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 441770007979 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 441770007980 Carbohydrate binding domain; Region: CBM_25; smart01066 441770007981 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 441770007982 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 441770007983 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441770007984 dimerization interface [polypeptide binding]; other site 441770007985 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770007986 dimer interface [polypeptide binding]; other site 441770007987 putative CheW interface [polypeptide binding]; other site 441770007988 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 441770007989 nudix motif; other site 441770007990 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 441770007991 metal binding site 2 [ion binding]; metal-binding site 441770007992 putative DNA binding helix; other site 441770007993 metal binding site 1 [ion binding]; metal-binding site 441770007994 dimer interface [polypeptide binding]; other site 441770007995 structural Zn2+ binding site [ion binding]; other site 441770007996 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 441770007997 Glyco_18 domain; Region: Glyco_18; smart00636 441770007998 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 441770007999 active site 441770008000 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 441770008001 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 441770008002 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 441770008003 active site 441770008004 trimer interface [polypeptide binding]; other site 441770008005 allosteric site; other site 441770008006 active site lid [active] 441770008007 hexamer (dimer of trimers) interface [polypeptide binding]; other site 441770008008 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 441770008009 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 441770008010 active site 441770008011 dimer interface [polypeptide binding]; other site 441770008012 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 441770008013 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770008014 DNA-binding site [nucleotide binding]; DNA binding site 441770008015 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 441770008016 transcriptional antiterminator BglG; Provisional; Region: PRK09772 441770008017 CAT RNA binding domain; Region: CAT_RBD; smart01061 441770008018 PRD domain; Region: PRD; pfam00874 441770008019 PRD domain; Region: PRD; pfam00874 441770008020 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 441770008021 HPr interaction site; other site 441770008022 glycerol kinase (GK) interaction site [polypeptide binding]; other site 441770008023 active site 441770008024 phosphorylation site [posttranslational modification] 441770008025 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441770008026 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 441770008027 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441770008028 active site turn [active] 441770008029 phosphorylation site [posttranslational modification] 441770008030 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 441770008031 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441770008032 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441770008033 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 441770008034 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 441770008035 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441770008036 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 441770008037 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 441770008038 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 441770008039 FAD binding site [chemical binding]; other site 441770008040 homotetramer interface [polypeptide binding]; other site 441770008041 substrate binding pocket [chemical binding]; other site 441770008042 catalytic base [active] 441770008043 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 441770008044 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 441770008045 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 441770008046 Rubredoxin; Region: Rubredoxin; pfam00301 441770008047 iron binding site [ion binding]; other site 441770008048 Integrase core domain; Region: rve; pfam00665 441770008049 Integrase core domain; Region: rve_2; pfam13333 441770008050 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 441770008051 Domain of unknown function (DUF956); Region: DUF956; pfam06115 441770008052 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 441770008053 Coenzyme A transferase; Region: CoA_trans; cl17247 441770008054 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 441770008055 Ligand binding site; other site 441770008056 metal-binding site 441770008057 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 441770008058 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441770008059 catalytic loop [active] 441770008060 iron binding site [ion binding]; other site 441770008061 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 441770008062 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 441770008063 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 441770008064 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 441770008065 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441770008066 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441770008067 similar to hypothetical protein; identified by Glimmer3 441770008068 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 441770008069 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 441770008070 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 441770008071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441770008072 motif II; other site 441770008073 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 441770008074 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770008075 FeS/SAM binding site; other site 441770008076 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 441770008077 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441770008078 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441770008079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770008080 Walker A/P-loop; other site 441770008081 ATP binding site [chemical binding]; other site 441770008082 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 441770008083 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 441770008084 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 441770008085 cofactor binding site; other site 441770008086 DNA binding site [nucleotide binding] 441770008087 substrate interaction site [chemical binding]; other site 441770008088 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 441770008089 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 441770008090 amidase catalytic site [active] 441770008091 Zn binding residues [ion binding]; other site 441770008092 substrate binding site [chemical binding]; other site 441770008093 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441770008094 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 441770008095 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 441770008096 YvrJ protein family; Region: YvrJ; pfam12841 441770008097 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 441770008098 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441770008099 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 441770008100 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 441770008101 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 441770008102 Helix-turn-helix domain; Region: HTH_17; pfam12728 441770008103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 441770008104 non-specific DNA binding site [nucleotide binding]; other site 441770008105 salt bridge; other site 441770008106 sequence-specific DNA binding site [nucleotide binding]; other site 441770008107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770008108 non-specific DNA binding site [nucleotide binding]; other site 441770008109 salt bridge; other site 441770008110 sequence-specific DNA binding site [nucleotide binding]; other site 441770008111 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 441770008112 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 441770008113 Int/Topo IB signature motif; other site 441770008114 TRAM domain; Region: TRAM; cl01282 441770008115 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 441770008116 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 441770008117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770008118 S-adenosylmethionine binding site [chemical binding]; other site 441770008119 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 441770008120 Sulfatase; Region: Sulfatase; pfam00884 441770008121 hypothetical protein; Provisional; Region: PRK10621 441770008122 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441770008123 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 441770008124 homopentamer interface [polypeptide binding]; other site 441770008125 active site 441770008126 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 441770008127 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 441770008128 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 441770008129 dimerization interface [polypeptide binding]; other site 441770008130 active site 441770008131 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 441770008132 Lumazine binding domain; Region: Lum_binding; pfam00677 441770008133 Lumazine binding domain; Region: Lum_binding; pfam00677 441770008134 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 441770008135 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 441770008136 catalytic motif [active] 441770008137 Zn binding site [ion binding]; other site 441770008138 RibD C-terminal domain; Region: RibD_C; cl17279 441770008139 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 441770008140 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 441770008141 metal binding site [ion binding]; metal-binding site 441770008142 dimer interface [polypeptide binding]; other site 441770008143 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441770008144 magnesium-transporting ATPase; Provisional; Region: PRK15122 441770008145 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 441770008146 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441770008147 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 441770008148 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441770008149 motif II; other site 441770008150 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 441770008151 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 441770008152 active site 441770008153 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 441770008154 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 441770008155 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 441770008156 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 441770008157 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 441770008158 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 441770008159 purine monophosphate binding site [chemical binding]; other site 441770008160 dimer interface [polypeptide binding]; other site 441770008161 putative catalytic residues [active] 441770008162 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 441770008163 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 441770008164 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 441770008165 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 441770008166 active site 441770008167 substrate binding site [chemical binding]; other site 441770008168 cosubstrate binding site; other site 441770008169 catalytic site [active] 441770008170 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 441770008171 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 441770008172 dimerization interface [polypeptide binding]; other site 441770008173 putative ATP binding site [chemical binding]; other site 441770008174 amidophosphoribosyltransferase; Provisional; Region: PRK05793 441770008175 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 441770008176 active site 441770008177 tetramer interface [polypeptide binding]; other site 441770008178 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441770008179 active site 441770008180 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 441770008181 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 441770008182 ATP binding site [chemical binding]; other site 441770008183 active site 441770008184 substrate binding site [chemical binding]; other site 441770008185 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 441770008186 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 441770008187 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441770008188 catalytic loop [active] 441770008189 iron binding site [ion binding]; other site 441770008190 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 441770008191 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441770008192 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441770008193 putative selenium metabolism hydrolase; Region: selenium_YgeY; TIGR03526 441770008194 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 441770008195 putative metal binding site [ion binding]; other site 441770008196 putative dimer interface [polypeptide binding]; other site 441770008197 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 441770008198 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 441770008199 active site 441770008200 putative substrate binding pocket [chemical binding]; other site 441770008201 putative selenate reductase, YgfK subunit; Region: Se_ygfK; TIGR03315 441770008202 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 441770008203 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 441770008204 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 441770008205 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 441770008206 phenylhydantoinase; Validated; Region: PRK08323 441770008207 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 441770008208 tetramer interface [polypeptide binding]; other site 441770008209 active site 441770008210 xanthine permease; Region: pbuX; TIGR03173 441770008211 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 441770008212 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 441770008213 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441770008214 catalytic residue [active] 441770008215 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 441770008216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770008217 Walker A motif; other site 441770008218 ATP binding site [chemical binding]; other site 441770008219 Walker B motif; other site 441770008220 arginine finger; other site 441770008221 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441770008222 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 441770008223 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 441770008224 Ligand binding site; other site 441770008225 metal-binding site 441770008226 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 441770008227 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 441770008228 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 441770008229 XdhC Rossmann domain; Region: XdhC_C; pfam13478 441770008230 NTPase; Region: NTPase_1; pfam03266 441770008231 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 441770008232 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 441770008233 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441770008234 ABC-ATPase subunit interface; other site 441770008235 dimer interface [polypeptide binding]; other site 441770008236 putative PBP binding regions; other site 441770008237 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 441770008238 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 441770008239 Walker A/P-loop; other site 441770008240 ATP binding site [chemical binding]; other site 441770008241 Q-loop/lid; other site 441770008242 ABC transporter signature motif; other site 441770008243 Walker B; other site 441770008244 D-loop; other site 441770008245 H-loop/switch region; other site 441770008246 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 441770008247 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 441770008248 intersubunit interface [polypeptide binding]; other site 441770008249 ALIX V-shaped domain binding to HIV; Region: ALIX_LYPXL_bnd; pfam13949 441770008250 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 441770008251 active site 441770008252 catalytic triad [active] 441770008253 oxyanion hole [active] 441770008254 Uncharacterized conserved protein [Function unknown]; Region: COG1434 441770008255 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 441770008256 putative active site [active] 441770008257 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 441770008258 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 441770008259 amino acid carrier protein; Region: agcS; TIGR00835 441770008260 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 441770008261 Part of AAA domain; Region: AAA_19; pfam13245 441770008262 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 441770008263 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 441770008264 Ligand Binding Site [chemical binding]; other site 441770008265 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 441770008266 putative metal binding site [ion binding]; other site 441770008267 putative dimer interface [polypeptide binding]; other site 441770008268 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 441770008269 GAF domain; Region: GAF_2; pfam13185 441770008270 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 441770008271 Domain of unknown function DUF21; Region: DUF21; pfam01595 441770008272 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 441770008273 Transporter associated domain; Region: CorC_HlyC; pfam03471 441770008274 Domain of unknown function DUF77; Region: DUF77; pfam01910 441770008275 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 441770008276 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 441770008277 amidophosphoribosyltransferase; Provisional; Region: PRK05793 441770008278 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 441770008279 active site 441770008280 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441770008281 Protein of unknown function (DUF503); Region: DUF503; pfam04456 441770008282 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 441770008283 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 441770008284 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441770008285 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441770008286 Walker A/P-loop; other site 441770008287 ATP binding site [chemical binding]; other site 441770008288 Q-loop/lid; other site 441770008289 ABC transporter signature motif; other site 441770008290 Walker B; other site 441770008291 D-loop; other site 441770008292 H-loop/switch region; other site 441770008293 Predicted transcriptional regulators [Transcription]; Region: COG1725 441770008294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770008295 DNA-binding site [nucleotide binding]; DNA binding site 441770008296 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 441770008297 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 441770008298 Ferredoxin [Energy production and conversion]; Region: COG1146 441770008299 4Fe-4S binding domain; Region: Fer4_6; pfam12837 441770008300 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441770008301 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441770008302 ligand binding site [chemical binding]; other site 441770008303 flexible hinge region; other site 441770008304 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 441770008305 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 441770008306 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 441770008307 Predicted membrane protein [Function unknown]; Region: COG1511 441770008308 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 441770008309 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 441770008310 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 441770008311 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 441770008312 active site 441770008313 catalytic site [active] 441770008314 metal binding site [ion binding]; metal-binding site 441770008315 dimer interface [polypeptide binding]; other site 441770008316 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 441770008317 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441770008318 catalytic residue [active] 441770008319 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441770008320 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 441770008321 Putative zinc ribbon domain; Region: DUF164; pfam02591 441770008322 Uncharacterized conserved protein [Function unknown]; Region: COG0327 441770008323 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 441770008324 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 441770008325 Family of unknown function (DUF633); Region: DUF633; pfam04816 441770008326 Protein of unknown function (DUF2679); Region: DUF2679; pfam10882 441770008327 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 441770008328 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 441770008329 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 441770008330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441770008331 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 441770008332 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441770008333 DNA binding residues [nucleotide binding] 441770008334 DNA primase, catalytic core; Region: dnaG; TIGR01391 441770008335 CHC2 zinc finger; Region: zf-CHC2; pfam01807 441770008336 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 441770008337 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 441770008338 active site 441770008339 metal binding site [ion binding]; metal-binding site 441770008340 interdomain interaction site; other site 441770008341 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 441770008342 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 441770008343 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441770008344 Zn2+ binding site [ion binding]; other site 441770008345 Mg2+ binding site [ion binding]; other site 441770008346 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 441770008347 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 441770008348 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 441770008349 pyruvate phosphate dikinase; Provisional; Region: PRK09279 441770008350 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 441770008351 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 441770008352 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 441770008353 HTH domain; Region: HTH_11; pfam08279 441770008354 FOG: CBS domain [General function prediction only]; Region: COG0517 441770008355 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 441770008356 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 441770008357 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 441770008358 GTPase Era; Reviewed; Region: era; PRK00089 441770008359 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 441770008360 G1 box; other site 441770008361 GTP/Mg2+ binding site [chemical binding]; other site 441770008362 Switch I region; other site 441770008363 G2 box; other site 441770008364 Switch II region; other site 441770008365 G3 box; other site 441770008366 G4 box; other site 441770008367 G5 box; other site 441770008368 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 441770008369 active site 441770008370 catalytic motif [active] 441770008371 Zn binding site [ion binding]; other site 441770008372 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 441770008373 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 441770008374 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 441770008375 active site 441770008376 metal-binding heat shock protein; Provisional; Region: PRK00016 441770008377 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 441770008378 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 441770008379 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441770008380 Zn2+ binding site [ion binding]; other site 441770008381 Mg2+ binding site [ion binding]; other site 441770008382 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 441770008383 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 441770008384 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 441770008385 Yqey-like protein; Region: YqeY; pfam09424 441770008386 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 441770008387 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 441770008388 nucleotide binding site/active site [active] 441770008389 HIT family signature motif; other site 441770008390 catalytic residue [active] 441770008391 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 441770008392 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 441770008393 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770008394 FeS/SAM binding site; other site 441770008395 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 441770008396 RNA methyltransferase, RsmE family; Region: TIGR00046 441770008397 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 441770008398 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 441770008399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770008400 S-adenosylmethionine binding site [chemical binding]; other site 441770008401 chaperone protein DnaJ; Provisional; Region: PRK14297 441770008402 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 441770008403 HSP70 interaction site [polypeptide binding]; other site 441770008404 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 441770008405 substrate binding site [polypeptide binding]; other site 441770008406 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 441770008407 Zn binding sites [ion binding]; other site 441770008408 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 441770008409 dimer interface [polypeptide binding]; other site 441770008410 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 441770008411 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 441770008412 nucleotide binding site [chemical binding]; other site 441770008413 NEF interaction site [polypeptide binding]; other site 441770008414 SBD interface [polypeptide binding]; other site 441770008415 GrpE; Region: GrpE; pfam01025 441770008416 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 441770008417 dimer interface [polypeptide binding]; other site 441770008418 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 441770008419 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 441770008420 HTH domain; Region: HTH_11; cl17392 441770008421 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 441770008422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770008423 FeS/SAM binding site; other site 441770008424 HemN C-terminal domain; Region: HemN_C; pfam06969 441770008425 GTP-binding protein LepA; Provisional; Region: PRK05433 441770008426 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 441770008427 G1 box; other site 441770008428 putative GEF interaction site [polypeptide binding]; other site 441770008429 GTP/Mg2+ binding site [chemical binding]; other site 441770008430 Switch I region; other site 441770008431 G2 box; other site 441770008432 G3 box; other site 441770008433 Switch II region; other site 441770008434 G4 box; other site 441770008435 G5 box; other site 441770008436 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 441770008437 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 441770008438 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 441770008439 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 441770008440 stage II sporulation protein P; Region: spore_II_P; TIGR02867 441770008441 germination protease; Provisional; Region: PRK12362 441770008442 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 441770008443 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 441770008444 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 441770008445 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 441770008446 Competence protein; Region: Competence; pfam03772 441770008447 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 441770008448 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 441770008449 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441770008450 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 441770008451 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 441770008452 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 441770008453 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770008454 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441770008455 non-specific DNA binding site [nucleotide binding]; other site 441770008456 salt bridge; other site 441770008457 sequence-specific DNA binding site [nucleotide binding]; other site 441770008458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770008459 non-specific DNA binding site [nucleotide binding]; other site 441770008460 salt bridge; other site 441770008461 sequence-specific DNA binding site [nucleotide binding]; other site 441770008462 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 441770008463 Replication-relaxation; Region: Replic_Relax; pfam13814 441770008464 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 441770008465 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770008466 non-specific DNA binding site [nucleotide binding]; other site 441770008467 salt bridge; other site 441770008468 sequence-specific DNA binding site [nucleotide binding]; other site 441770008469 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 441770008470 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 441770008471 active site 441770008472 metal binding site [ion binding]; metal-binding site 441770008473 Bacterial SH3 domain; Region: SH3_3; pfam08239 441770008474 Holin family; Region: Phage_holin_4; pfam05105 441770008475 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 441770008476 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 441770008477 active site 441770008478 Haemolysin XhlA; Region: XhlA; pfam10779 441770008479 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 441770008480 Phage tail protein; Region: Sipho_tail; pfam05709 441770008481 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 441770008482 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 441770008483 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 441770008484 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 441770008485 Phage capsid family; Region: Phage_capsid; pfam05065 441770008486 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 441770008487 oligomer interface [polypeptide binding]; other site 441770008488 Clp protease; Region: CLP_protease; pfam00574 441770008489 active site residues [active] 441770008490 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 441770008491 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 441770008492 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 441770008493 Phage terminase, small subunit; Region: Terminase_4; cl01525 441770008494 YjcQ protein; Region: YjcQ; pfam09639 441770008495 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 441770008496 Int/Topo IB signature motif; other site 441770008497 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 441770008498 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 441770008499 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441770008500 active site 441770008501 DNA binding site [nucleotide binding] 441770008502 Int/Topo IB signature motif; other site 441770008503 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 441770008504 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 441770008505 cofactor binding site; other site 441770008506 DNA binding site [nucleotide binding] 441770008507 substrate interaction site [chemical binding]; other site 441770008508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770008509 Walker A motif; other site 441770008510 ATP binding site [chemical binding]; other site 441770008511 Walker B motif; other site 441770008512 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 441770008513 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 441770008514 ORF6N domain; Region: ORF6N; pfam10543 441770008515 ORF6C domain; Region: ORF6C; pfam10552 441770008516 Helix-turn-helix domain; Region: HTH_17; cl17695 441770008517 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770008518 non-specific DNA binding site [nucleotide binding]; other site 441770008519 salt bridge; other site 441770008520 sequence-specific DNA binding site [nucleotide binding]; other site 441770008521 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770008522 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441770008523 non-specific DNA binding site [nucleotide binding]; other site 441770008524 salt bridge; other site 441770008525 sequence-specific DNA binding site [nucleotide binding]; other site 441770008526 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 441770008527 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 441770008528 Int/Topo IB signature motif; other site 441770008529 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 441770008530 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 441770008531 G1 box; other site 441770008532 putative GEF interaction site [polypeptide binding]; other site 441770008533 GTP/Mg2+ binding site [chemical binding]; other site 441770008534 Switch I region; other site 441770008535 G2 box; other site 441770008536 G3 box; other site 441770008537 Switch II region; other site 441770008538 G4 box; other site 441770008539 G5 box; other site 441770008540 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 441770008541 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 441770008542 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 441770008543 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 441770008544 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 441770008545 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 441770008546 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 441770008547 selenophosphate synthetase; Provisional; Region: PRK00943 441770008548 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 441770008549 dimerization interface [polypeptide binding]; other site 441770008550 putative ATP binding site [chemical binding]; other site 441770008551 SLBB domain; Region: SLBB; pfam10531 441770008552 Helix-hairpin-helix motif; Region: HHH; pfam00633 441770008553 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 441770008554 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 441770008555 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 441770008556 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441770008557 RNA binding surface [nucleotide binding]; other site 441770008558 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 441770008559 active site 441770008560 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 441770008561 homotrimer interaction site [polypeptide binding]; other site 441770008562 putative active site [active] 441770008563 Transcriptional regulator [Transcription]; Region: LytR; COG1316 441770008564 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 441770008565 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441770008566 Zn2+ binding site [ion binding]; other site 441770008567 Mg2+ binding site [ion binding]; other site 441770008568 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 441770008569 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 441770008570 active site 441770008571 (T/H)XGH motif; other site 441770008572 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 441770008573 GTPase CgtA; Reviewed; Region: obgE; PRK12297 441770008574 GTP1/OBG; Region: GTP1_OBG; pfam01018 441770008575 Obg GTPase; Region: Obg; cd01898 441770008576 G1 box; other site 441770008577 GTP/Mg2+ binding site [chemical binding]; other site 441770008578 Switch I region; other site 441770008579 G2 box; other site 441770008580 G3 box; other site 441770008581 Switch II region; other site 441770008582 G4 box; other site 441770008583 G5 box; other site 441770008584 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 441770008585 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 441770008586 hypothetical protein; Provisional; Region: PRK14553 441770008587 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 441770008588 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 441770008589 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 441770008590 homodimer interface [polypeptide binding]; other site 441770008591 oligonucleotide binding site [chemical binding]; other site 441770008592 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 441770008593 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 441770008594 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 441770008595 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770008596 FeS/SAM binding site; other site 441770008597 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 441770008598 Peptidase family M50; Region: Peptidase_M50; pfam02163 441770008599 active site 441770008600 putative substrate binding region [chemical binding]; other site 441770008601 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 441770008602 Peptidase family M23; Region: Peptidase_M23; pfam01551 441770008603 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 441770008604 cell division topological specificity factor MinE; Provisional; Region: PRK13987 441770008605 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 441770008606 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 441770008607 Switch I; other site 441770008608 Switch II; other site 441770008609 septum formation inhibitor; Reviewed; Region: minC; PRK00513 441770008610 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 441770008611 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 441770008612 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 441770008613 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 441770008614 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 441770008615 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 441770008616 rod shape-determining protein MreC; Provisional; Region: PRK13922 441770008617 rod shape-determining protein MreC; Region: MreC; pfam04085 441770008618 rod shape-determining protein MreB; Provisional; Region: PRK13927 441770008619 MreB and similar proteins; Region: MreB_like; cd10225 441770008620 nucleotide binding site [chemical binding]; other site 441770008621 Mg binding site [ion binding]; other site 441770008622 putative protofilament interaction site [polypeptide binding]; other site 441770008623 RodZ interaction site [polypeptide binding]; other site 441770008624 hypothetical protein; Reviewed; Region: PRK00024 441770008625 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 441770008626 helix-hairpin-helix signature motif; other site 441770008627 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 441770008628 MPN+ (JAMM) motif; other site 441770008629 Zinc-binding site [ion binding]; other site 441770008630 Maf-like protein; Reviewed; Region: PRK00078 441770008631 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 441770008632 active site 441770008633 dimer interface [polypeptide binding]; other site 441770008634 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 441770008635 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 441770008636 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 441770008637 hypothetical protein; Provisional; Region: PRK04435 441770008638 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 441770008639 DNA-binding interface [nucleotide binding]; DNA binding site 441770008640 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 441770008641 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 441770008642 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441770008643 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441770008644 catalytic residue [active] 441770008645 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 441770008646 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 441770008647 CoA-binding site [chemical binding]; other site 441770008648 ATP-binding [chemical binding]; other site 441770008649 DNA polymerase I; Provisional; Region: PRK05755 441770008650 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 441770008651 active site 441770008652 metal binding site 1 [ion binding]; metal-binding site 441770008653 putative 5' ssDNA interaction site; other site 441770008654 metal binding site 3; metal-binding site 441770008655 metal binding site 2 [ion binding]; metal-binding site 441770008656 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 441770008657 putative DNA binding site [nucleotide binding]; other site 441770008658 putative metal binding site [ion binding]; other site 441770008659 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 441770008660 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 441770008661 active site 441770008662 DNA binding site [nucleotide binding] 441770008663 catalytic site [active] 441770008664 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 441770008665 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 441770008666 Tetramer interface [polypeptide binding]; other site 441770008667 active site 441770008668 FMN-binding site [chemical binding]; other site 441770008669 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 441770008670 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 441770008671 active site 441770008672 metal binding site [ion binding]; metal-binding site 441770008673 Bacterial SH3 domain; Region: SH3_3; pfam08239 441770008674 Haemolysin XhlA; Region: XhlA; pfam10779 441770008675 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 441770008676 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 441770008677 Caspase domain; Region: Peptidase_C14; pfam00656 441770008678 DivIVA protein; Region: DivIVA; pfam05103 441770008679 hypothetical protein; Validated; Region: PRK08116 441770008680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770008681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 441770008682 Walker A motif; other site 441770008683 ATP binding site [chemical binding]; other site 441770008684 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 441770008685 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 441770008686 non-specific DNA binding site [nucleotide binding]; other site 441770008687 salt bridge; other site 441770008688 sequence-specific DNA binding site [nucleotide binding]; other site 441770008689 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770008690 non-specific DNA binding site [nucleotide binding]; other site 441770008691 salt bridge; other site 441770008692 sequence-specific DNA binding site [nucleotide binding]; other site 441770008693 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441770008694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770008695 non-specific DNA binding site [nucleotide binding]; other site 441770008696 salt bridge; other site 441770008697 sequence-specific DNA binding site [nucleotide binding]; other site 441770008698 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 441770008699 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 441770008700 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 441770008701 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 441770008702 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 441770008703 dimer interface [polypeptide binding]; other site 441770008704 anticodon binding site; other site 441770008705 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 441770008706 homodimer interface [polypeptide binding]; other site 441770008707 motif 1; other site 441770008708 active site 441770008709 motif 2; other site 441770008710 GAD domain; Region: GAD; pfam02938 441770008711 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 441770008712 motif 3; other site 441770008713 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 441770008714 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 441770008715 dimer interface [polypeptide binding]; other site 441770008716 motif 1; other site 441770008717 active site 441770008718 motif 2; other site 441770008719 motif 3; other site 441770008720 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 441770008721 anticodon binding site; other site 441770008722 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 441770008723 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770008724 FeS/SAM binding site; other site 441770008725 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441770008726 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 441770008727 putative active site [active] 441770008728 dimerization interface [polypeptide binding]; other site 441770008729 putative tRNAtyr binding site [nucleotide binding]; other site 441770008730 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 441770008731 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441770008732 Zn2+ binding site [ion binding]; other site 441770008733 Mg2+ binding site [ion binding]; other site 441770008734 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 441770008735 synthetase active site [active] 441770008736 NTP binding site [chemical binding]; other site 441770008737 metal binding site [ion binding]; metal-binding site 441770008738 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 441770008739 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 441770008740 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441770008741 active site 441770008742 DHH family; Region: DHH; pfam01368 441770008743 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 441770008744 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 441770008745 Protein export membrane protein; Region: SecD_SecF; pfam02355 441770008746 protein-export membrane protein SecD; Region: secD; TIGR01129 441770008747 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 441770008748 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 441770008749 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770008750 FeS/SAM binding site; other site 441770008751 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 441770008752 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 441770008753 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 441770008754 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 441770008755 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 441770008756 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 441770008757 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 441770008758 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 441770008759 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 441770008760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770008761 Walker A motif; other site 441770008762 ATP binding site [chemical binding]; other site 441770008763 Walker B motif; other site 441770008764 arginine finger; other site 441770008765 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 441770008766 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 441770008767 RuvA N terminal domain; Region: RuvA_N; pfam01330 441770008768 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 441770008769 hypothetical protein; Validated; Region: PRK00110 441770008770 Uncharacterized conserved protein [Function unknown]; Region: COG1739 441770008771 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 441770008772 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 441770008773 HEAT repeats; Region: HEAT_2; pfam13646 441770008774 HEAT-like repeat; Region: HEAT_EZ; pfam13513 441770008775 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 441770008776 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441770008777 DNA-binding site [nucleotide binding]; DNA binding site 441770008778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770008779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770008780 homodimer interface [polypeptide binding]; other site 441770008781 catalytic residue [active] 441770008782 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 441770008783 active site 441770008784 NTP binding site [chemical binding]; other site 441770008785 metal binding triad [ion binding]; metal-binding site 441770008786 antibiotic binding site [chemical binding]; other site 441770008787 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 441770008788 Rubredoxin; Region: Rubredoxin; pfam00301 441770008789 iron binding site [ion binding]; other site 441770008790 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 441770008791 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 441770008792 HflX GTPase family; Region: HflX; cd01878 441770008793 G1 box; other site 441770008794 GTP/Mg2+ binding site [chemical binding]; other site 441770008795 Switch I region; other site 441770008796 G2 box; other site 441770008797 G3 box; other site 441770008798 Switch II region; other site 441770008799 G4 box; other site 441770008800 G5 box; other site 441770008801 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441770008802 active site 441770008803 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 441770008804 Transglycosylase; Region: Transgly; pfam00912 441770008805 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 441770008806 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 441770008807 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 441770008808 stage V sporulation protein AD; Validated; Region: PRK08304 441770008809 stage V sporulation protein AD; Provisional; Region: PRK12404 441770008810 SpoVA protein; Region: SpoVA; cl04298 441770008811 sporulation sigma factor SigF; Validated; Region: PRK05572 441770008812 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441770008813 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 441770008814 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441770008815 DNA binding residues [nucleotide binding] 441770008816 anti-sigma F factor; Provisional; Region: PRK03660 441770008817 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 441770008818 ATP binding site [chemical binding]; other site 441770008819 Mg2+ binding site [ion binding]; other site 441770008820 G-X-G motif; other site 441770008821 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 441770008822 anti sigma factor interaction site; other site 441770008823 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 441770008824 regulatory phosphorylation site [posttranslational modification]; other site 441770008825 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 441770008826 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 441770008827 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 441770008828 NodB motif; other site 441770008829 active site 441770008830 catalytic site [active] 441770008831 Cd binding site [ion binding]; other site 441770008832 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 441770008833 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 441770008834 Bacterial sugar transferase; Region: Bac_transf; pfam02397 441770008835 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 441770008836 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 441770008837 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 441770008838 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 441770008839 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 441770008840 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 441770008841 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441770008842 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441770008843 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 441770008844 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 441770008845 O-Antigen ligase; Region: Wzy_C; pfam04932 441770008846 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 441770008847 putative glycosyl transferase; Provisional; Region: PRK10307 441770008848 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 441770008849 active site 441770008850 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 441770008851 homodimer interface [polypeptide binding]; other site 441770008852 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 441770008853 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441770008854 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441770008855 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 441770008856 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441770008857 Leucine-rich repeats; other site 441770008858 Substrate binding site [chemical binding]; other site 441770008859 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441770008860 Leucine rich repeat; Region: LRR_8; pfam13855 441770008861 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441770008862 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 441770008863 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 441770008864 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 441770008865 putative trimer interface [polypeptide binding]; other site 441770008866 putative CoA binding site [chemical binding]; other site 441770008867 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 441770008868 putative trimer interface [polypeptide binding]; other site 441770008869 putative active site [active] 441770008870 putative substrate binding site [chemical binding]; other site 441770008871 putative CoA binding site [chemical binding]; other site 441770008872 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 441770008873 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 441770008874 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 441770008875 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 441770008876 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 441770008877 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 441770008878 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 441770008879 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 441770008880 NAD(P) binding site [chemical binding]; other site 441770008881 homodimer interface [polypeptide binding]; other site 441770008882 substrate binding site [chemical binding]; other site 441770008883 active site 441770008884 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 441770008885 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 441770008886 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 441770008887 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 441770008888 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 441770008889 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 441770008890 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 441770008891 active site 441770008892 metal binding site [ion binding]; metal-binding site 441770008893 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 441770008894 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 441770008895 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 441770008896 active site 441770008897 metal binding site [ion binding]; metal-binding site 441770008898 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 441770008899 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 441770008900 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 441770008901 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 441770008902 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 441770008903 active site 441770008904 tetramer interface; other site 441770008905 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441770008906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441770008907 binding surface 441770008908 TPR motif; other site 441770008909 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 441770008910 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 441770008911 active site 441770008912 substrate binding site [chemical binding]; other site 441770008913 metal binding site [ion binding]; metal-binding site 441770008914 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 441770008915 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 441770008916 5S rRNA interface [nucleotide binding]; other site 441770008917 CTC domain interface [polypeptide binding]; other site 441770008918 L16 interface [polypeptide binding]; other site 441770008919 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 441770008920 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 441770008921 homodimer interface [polypeptide binding]; other site 441770008922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770008923 catalytic residue [active] 441770008924 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 441770008925 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 441770008926 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 441770008927 active site 441770008928 substrate binding site [chemical binding]; other site 441770008929 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 441770008930 FMN binding site [chemical binding]; other site 441770008931 putative catalytic residues [active] 441770008932 Uncharacterized conserved protein [Function unknown]; Region: COG1683 441770008933 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 441770008934 MutS domain III; Region: MutS_III; pfam05192 441770008935 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 441770008936 Walker A/P-loop; other site 441770008937 ATP binding site [chemical binding]; other site 441770008938 Q-loop/lid; other site 441770008939 ABC transporter signature motif; other site 441770008940 Walker B; other site 441770008941 D-loop; other site 441770008942 H-loop/switch region; other site 441770008943 Smr domain; Region: Smr; pfam01713 441770008944 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 441770008945 Peptidase family U32; Region: Peptidase_U32; pfam01136 441770008946 Collagenase; Region: DUF3656; pfam12392 441770008947 Peptidase family U32; Region: Peptidase_U32; cl03113 441770008948 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 441770008949 Cell division protein ZapA; Region: ZapA; pfam05164 441770008950 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 441770008951 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 441770008952 putative tRNA-binding site [nucleotide binding]; other site 441770008953 B3/4 domain; Region: B3_4; pfam03483 441770008954 tRNA synthetase B5 domain; Region: B5; smart00874 441770008955 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 441770008956 dimer interface [polypeptide binding]; other site 441770008957 motif 1; other site 441770008958 motif 3; other site 441770008959 motif 2; other site 441770008960 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 441770008961 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 441770008962 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 441770008963 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 441770008964 dimer interface [polypeptide binding]; other site 441770008965 motif 1; other site 441770008966 active site 441770008967 motif 2; other site 441770008968 motif 3; other site 441770008969 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 441770008970 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 441770008971 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 441770008972 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 441770008973 TrkA-N domain; Region: TrkA_N; pfam02254 441770008974 TrkA-C domain; Region: TrkA_C; pfam02080 441770008975 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 441770008976 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 441770008977 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 441770008978 23S rRNA binding site [nucleotide binding]; other site 441770008979 L21 binding site [polypeptide binding]; other site 441770008980 L13 binding site [polypeptide binding]; other site 441770008981 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 441770008982 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 441770008983 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 441770008984 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 441770008985 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 441770008986 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 441770008987 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 441770008988 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 441770008989 active site 441770008990 dimer interface [polypeptide binding]; other site 441770008991 motif 1; other site 441770008992 motif 2; other site 441770008993 motif 3; other site 441770008994 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 441770008995 anticodon binding site; other site 441770008996 YtxC-like family; Region: YtxC; pfam08812 441770008997 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 441770008998 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441770008999 Walker A/P-loop; other site 441770009000 ATP binding site [chemical binding]; other site 441770009001 Q-loop/lid; other site 441770009002 ABC transporter signature motif; other site 441770009003 Walker B; other site 441770009004 D-loop; other site 441770009005 H-loop/switch region; other site 441770009006 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 441770009007 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 441770009008 dimerization interface [polypeptide binding]; other site 441770009009 domain crossover interface; other site 441770009010 redox-dependent activation switch; other site 441770009011 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 441770009012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770009013 S-adenosylmethionine binding site [chemical binding]; other site 441770009014 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 441770009015 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 441770009016 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441770009017 Walker A/P-loop; other site 441770009018 ATP binding site [chemical binding]; other site 441770009019 Q-loop/lid; other site 441770009020 ABC transporter signature motif; other site 441770009021 Walker B; other site 441770009022 D-loop; other site 441770009023 H-loop/switch region; other site 441770009024 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 441770009025 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 441770009026 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441770009027 Walker A/P-loop; other site 441770009028 ATP binding site [chemical binding]; other site 441770009029 Q-loop/lid; other site 441770009030 ABC transporter signature motif; other site 441770009031 Walker B; other site 441770009032 D-loop; other site 441770009033 H-loop/switch region; other site 441770009034 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 441770009035 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 441770009036 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 441770009037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770009038 putative PBP binding loops; other site 441770009039 dimer interface [polypeptide binding]; other site 441770009040 ABC-ATPase subunit interface; other site 441770009041 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 441770009042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770009043 dimer interface [polypeptide binding]; other site 441770009044 conserved gate region; other site 441770009045 putative PBP binding loops; other site 441770009046 ABC-ATPase subunit interface; other site 441770009047 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 441770009048 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 441770009049 peptide binding site [polypeptide binding]; other site 441770009050 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 441770009051 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 441770009052 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 441770009053 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 441770009054 dimer interface [polypeptide binding]; other site 441770009055 active site 441770009056 catalytic residue [active] 441770009057 dihydrodipicolinate reductase; Provisional; Region: PRK00048 441770009058 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 441770009059 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 441770009060 aminotransferase A; Validated; Region: PRK07683 441770009061 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441770009062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770009063 homodimer interface [polypeptide binding]; other site 441770009064 catalytic residue [active] 441770009065 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 441770009066 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 441770009067 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 441770009068 trimer interface [polypeptide binding]; other site 441770009069 active site 441770009070 substrate binding site [chemical binding]; other site 441770009071 CoA binding site [chemical binding]; other site 441770009072 single-stranded DNA-binding protein; Provisional; Region: PRK05813 441770009073 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 441770009074 dimer interface [polypeptide binding]; other site 441770009075 ssDNA binding site [nucleotide binding]; other site 441770009076 tetramer (dimer of dimers) interface [polypeptide binding]; other site 441770009077 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 441770009078 NodB motif; other site 441770009079 active site 441770009080 catalytic site [active] 441770009081 metal binding site [ion binding]; metal-binding site 441770009082 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 441770009083 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 441770009084 uncharacterized protein TIGR03905; Region: TIGR03905_4_Cys 441770009085 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 441770009086 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441770009087 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441770009088 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 441770009089 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441770009090 active site 441770009091 HIGH motif; other site 441770009092 nucleotide binding site [chemical binding]; other site 441770009093 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 441770009094 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 441770009095 active site 441770009096 KMSKS motif; other site 441770009097 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 441770009098 tRNA binding surface [nucleotide binding]; other site 441770009099 anticodon binding site; other site 441770009100 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 441770009101 putative acetyltransferase YhhY; Provisional; Region: PRK10140 441770009102 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770009103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 441770009104 Coenzyme A binding pocket [chemical binding]; other site 441770009105 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441770009106 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441770009107 Walker A/P-loop; other site 441770009108 ATP binding site [chemical binding]; other site 441770009109 Q-loop/lid; other site 441770009110 ABC transporter signature motif; other site 441770009111 Walker B; other site 441770009112 D-loop; other site 441770009113 H-loop/switch region; other site 441770009114 NMT1-like family; Region: NMT1_2; pfam13379 441770009115 NMT1/THI5 like; Region: NMT1; pfam09084 441770009116 Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; Region: CH; cl00030 441770009117 putative actin binding surface [polypeptide binding]; other site 441770009118 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 441770009119 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 441770009120 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 441770009121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 441770009122 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441770009123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 441770009124 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 441770009125 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 441770009126 Walker A/P-loop; other site 441770009127 ATP binding site [chemical binding]; other site 441770009128 Q-loop/lid; other site 441770009129 ABC transporter signature motif; other site 441770009130 Walker B; other site 441770009131 D-loop; other site 441770009132 H-loop/switch region; other site 441770009133 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 441770009134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441770009135 dimer interface [polypeptide binding]; other site 441770009136 conserved gate region; other site 441770009137 putative PBP binding loops; other site 441770009138 ABC-ATPase subunit interface; other site 441770009139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441770009140 TPR repeat; Region: TPR_11; pfam13414 441770009141 binding surface 441770009142 TPR motif; other site 441770009143 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 441770009144 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 441770009145 recombination regulator RecX; Provisional; Region: recX; PRK14134 441770009146 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 441770009147 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 441770009148 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 441770009149 QueT transporter; Region: QueT; pfam06177 441770009150 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 441770009151 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441770009152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 441770009153 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441770009154 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441770009155 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 441770009156 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 441770009157 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 441770009158 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 441770009159 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 441770009160 dimer interface [polypeptide binding]; other site 441770009161 active site 441770009162 glycine loop; other site 441770009163 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 441770009164 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 441770009165 sequence-specific DNA binding site [nucleotide binding]; other site 441770009166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 441770009167 salt bridge; other site 441770009168 Cupin domain; Region: Cupin_2; pfam07883 441770009169 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 441770009170 Dimer interface [polypeptide binding]; other site 441770009171 BRCT sequence motif; other site 441770009172 agmatine deiminase; Region: agmatine_aguA; TIGR03380 441770009173 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 441770009174 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 441770009175 metal ion-dependent adhesion site (MIDAS); other site 441770009176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770009177 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 441770009178 Walker A motif; other site 441770009179 ATP binding site [chemical binding]; other site 441770009180 Walker B motif; other site 441770009181 arginine finger; other site 441770009182 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528 441770009183 Uncharacterized conserved protein [Function unknown]; Region: COG1915 441770009184 Uncharacterized conserved protein [Function unknown]; Region: COG1915 441770009185 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 441770009186 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 441770009187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 441770009188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 441770009189 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 441770009190 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 441770009191 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 441770009192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770009193 Walker A motif; other site 441770009194 ATP binding site [chemical binding]; other site 441770009195 Walker B motif; other site 441770009196 arginine finger; other site 441770009197 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441770009198 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 441770009199 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 441770009200 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 441770009201 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 441770009202 Ligand binding site [chemical binding]; other site 441770009203 Electron transfer flavoprotein domain; Region: ETF; pfam01012 441770009204 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 441770009205 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 441770009206 FAD binding site [chemical binding]; other site 441770009207 homotetramer interface [polypeptide binding]; other site 441770009208 substrate binding pocket [chemical binding]; other site 441770009209 catalytic base [active] 441770009210 putative acyltransferase; Provisional; Region: PRK05790 441770009211 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 441770009212 dimer interface [polypeptide binding]; other site 441770009213 active site 441770009214 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 441770009215 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 441770009216 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 441770009217 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 441770009218 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 441770009219 substrate binding site [chemical binding]; other site 441770009220 oxyanion hole (OAH) forming residues; other site 441770009221 trimer interface [polypeptide binding]; other site 441770009222 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 441770009223 GIY-YIG motif/motif A; other site 441770009224 active site 441770009225 catalytic site [active] 441770009226 putative DNA binding site [nucleotide binding]; other site 441770009227 metal binding site [ion binding]; metal-binding site 441770009228 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 441770009229 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441770009230 Zn2+ binding site [ion binding]; other site 441770009231 Mg2+ binding site [ion binding]; other site 441770009232 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 441770009233 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 441770009234 homotetramer interface [polypeptide binding]; other site 441770009235 active site 441770009236 metal binding site [ion binding]; metal-binding site 441770009237 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 441770009238 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 441770009239 active site 441770009240 catalytic site [active] 441770009241 metal binding site [ion binding]; metal-binding site 441770009242 dimer interface [polypeptide binding]; other site 441770009243 Cache domain; Region: Cache_1; pfam02743 441770009244 HAMP domain; Region: HAMP; pfam00672 441770009245 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441770009246 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770009247 dimer interface [polypeptide binding]; other site 441770009248 putative CheW interface [polypeptide binding]; other site 441770009249 Rubredoxin [Energy production and conversion]; Region: COG1773 441770009250 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 441770009251 iron binding site [ion binding]; other site 441770009252 Rubrerythrin [Energy production and conversion]; Region: COG1592 441770009253 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 441770009254 diiron binding motif [ion binding]; other site 441770009255 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 441770009256 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770009257 FeS/SAM binding site; other site 441770009258 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 441770009259 Pyruvate formate lyase 1; Region: PFL1; cd01678 441770009260 coenzyme A binding site [chemical binding]; other site 441770009261 active site 441770009262 catalytic residues [active] 441770009263 glycine loop; other site 441770009264 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 441770009265 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 441770009266 5S rRNA interface [nucleotide binding]; other site 441770009267 CTC domain interface [polypeptide binding]; other site 441770009268 L16 interface [polypeptide binding]; other site 441770009269 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 441770009270 metal binding site 2 [ion binding]; metal-binding site 441770009271 putative DNA binding helix; other site 441770009272 metal binding site 1 [ion binding]; metal-binding site 441770009273 dimer interface [polypeptide binding]; other site 441770009274 structural Zn2+ binding site [ion binding]; other site 441770009275 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 441770009276 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 441770009277 HTH domain; Region: HTH_11; pfam08279 441770009278 WYL domain; Region: WYL; pfam13280 441770009279 CAAX protease self-immunity; Region: Abi; pfam02517 441770009280 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 441770009281 G1 box; other site 441770009282 GTP/Mg2+ binding site [chemical binding]; other site 441770009283 Switch I region; other site 441770009284 G2 box; other site 441770009285 G3 box; other site 441770009286 Switch II region; other site 441770009287 G4 box; other site 441770009288 G5 box; other site 441770009289 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 441770009290 Found in ATP-dependent protease La (LON); Region: LON; smart00464 441770009291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770009292 Walker A motif; other site 441770009293 ATP binding site [chemical binding]; other site 441770009294 Walker B motif; other site 441770009295 arginine finger; other site 441770009296 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 441770009297 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 441770009298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770009299 Walker A motif; other site 441770009300 ATP binding site [chemical binding]; other site 441770009301 Walker B motif; other site 441770009302 arginine finger; other site 441770009303 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 441770009304 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 441770009305 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 441770009306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770009307 Walker A motif; other site 441770009308 ATP binding site [chemical binding]; other site 441770009309 Walker B motif; other site 441770009310 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 441770009311 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 441770009312 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 441770009313 oligomer interface [polypeptide binding]; other site 441770009314 active site residues [active] 441770009315 trigger factor; Provisional; Region: tig; PRK01490 441770009316 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 441770009317 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 441770009318 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 441770009319 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 441770009320 DNA interaction; other site 441770009321 Metal-binding active site; metal-binding site 441770009322 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441770009323 active site 441770009324 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 441770009325 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 441770009326 heterodimer interface [polypeptide binding]; other site 441770009327 active site 441770009328 FMN binding site [chemical binding]; other site 441770009329 homodimer interface [polypeptide binding]; other site 441770009330 substrate binding site [chemical binding]; other site 441770009331 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 441770009332 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 441770009333 FAD binding pocket [chemical binding]; other site 441770009334 FAD binding motif [chemical binding]; other site 441770009335 phosphate binding motif [ion binding]; other site 441770009336 beta-alpha-beta structure motif; other site 441770009337 NAD binding pocket [chemical binding]; other site 441770009338 Iron coordination center [ion binding]; other site 441770009339 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 441770009340 active site 441770009341 dimer interface [polypeptide binding]; other site 441770009342 dihydroorotase; Validated; Region: pyrC; PRK09357 441770009343 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 441770009344 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 441770009345 active site 441770009346 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 441770009347 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 441770009348 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 441770009349 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 441770009350 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 441770009351 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 441770009352 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 441770009353 nucleotide binding site [chemical binding]; other site 441770009354 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 441770009355 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 441770009356 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441770009357 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441770009358 DsrE/DsrF-like family; Region: DrsE; cl00672 441770009359 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 441770009360 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 441770009361 Walker A/P-loop; other site 441770009362 ATP binding site [chemical binding]; other site 441770009363 Q-loop/lid; other site 441770009364 ABC transporter signature motif; other site 441770009365 Walker B; other site 441770009366 D-loop; other site 441770009367 H-loop/switch region; other site 441770009368 Alkylmercury lyase; Region: MerB; pfam03243 441770009369 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 441770009370 NMT1-like family; Region: NMT1_2; pfam13379 441770009371 Predicted permeases [General function prediction only]; Region: COG0701 441770009372 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 441770009373 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 441770009374 active site 441770009375 metal binding site [ion binding]; metal-binding site 441770009376 homotetramer interface [polypeptide binding]; other site 441770009377 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 441770009378 active site 441770009379 dimerization interface [polypeptide binding]; other site 441770009380 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 441770009381 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 441770009382 peptide binding site [polypeptide binding]; other site 441770009383 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 441770009384 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 441770009385 GatB domain; Region: GatB_Yqey; smart00845 441770009386 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 441770009387 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 441770009388 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 441770009389 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 441770009390 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 441770009391 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 441770009392 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 441770009393 nucleotide binding pocket [chemical binding]; other site 441770009394 K-X-D-G motif; other site 441770009395 catalytic site [active] 441770009396 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 441770009397 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 441770009398 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 441770009399 DNA binding site [nucleotide binding] 441770009400 metal binding site [ion binding]; metal-binding site 441770009401 Helix-hairpin-helix motif; Region: HHH; pfam00633 441770009402 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 441770009403 Dimer interface [polypeptide binding]; other site 441770009404 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 441770009405 Part of AAA domain; Region: AAA_19; pfam13245 441770009406 Family description; Region: UvrD_C_2; pfam13538 441770009407 Trp repressor protein; Region: Trp_repressor; cl17266 441770009408 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 441770009409 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441770009410 RNA binding surface [nucleotide binding]; other site 441770009411 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 441770009412 active site 441770009413 uracil binding [chemical binding]; other site 441770009414 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 441770009415 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 441770009416 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441770009417 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441770009418 catalytic residue [active] 441770009419 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 441770009420 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 441770009421 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 441770009422 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 441770009423 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 441770009424 hypothetical protein; Validated; Region: PRK00124 441770009425 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 441770009426 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 441770009427 active site 441770009428 dimer interface [polypeptide binding]; other site 441770009429 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 441770009430 dimer interface [polypeptide binding]; other site 441770009431 active site 441770009432 Probable zinc-binding domain; Region: zf-trcl; pfam13451 441770009433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441770009434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441770009435 D-lactate dehydrogenase; Validated; Region: PRK08605 441770009436 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 441770009437 homodimer interface [polypeptide binding]; other site 441770009438 ligand binding site [chemical binding]; other site 441770009439 NAD binding site [chemical binding]; other site 441770009440 catalytic site [active] 441770009441 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 441770009442 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 441770009443 putative ligand binding site [chemical binding]; other site 441770009444 putative NAD binding site [chemical binding]; other site 441770009445 catalytic site [active] 441770009446 Uncharacterized membrane protein [Function unknown]; Region: COG3949 441770009447 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 441770009448 4Fe-4S binding domain; Region: Fer4; pfam00037 441770009449 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 441770009450 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 441770009451 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 441770009452 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 441770009453 Ligand binding site [chemical binding]; other site 441770009454 Electron transfer flavoprotein domain; Region: ETF; pfam01012 441770009455 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 441770009456 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 441770009457 active site 441770009458 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 441770009459 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441770009460 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 441770009461 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441770009462 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 441770009463 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 441770009464 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 441770009465 CoA-transferase family III; Region: CoA_transf_3; pfam02515 441770009466 AMP-binding domain protein; Validated; Region: PRK08315 441770009467 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 441770009468 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 441770009469 acyl-activating enzyme (AAE) consensus motif; other site 441770009470 putative AMP binding site [chemical binding]; other site 441770009471 putative active site [active] 441770009472 putative CoA binding site [chemical binding]; other site 441770009473 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 441770009474 GMP synthase; Reviewed; Region: guaA; PRK00074 441770009475 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 441770009476 AMP/PPi binding site [chemical binding]; other site 441770009477 candidate oxyanion hole; other site 441770009478 catalytic triad [active] 441770009479 potential glutamine specificity residues [chemical binding]; other site 441770009480 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 441770009481 ATP Binding subdomain [chemical binding]; other site 441770009482 Ligand Binding sites [chemical binding]; other site 441770009483 Dimerization subdomain; other site 441770009484 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 441770009485 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 441770009486 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 441770009487 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 441770009488 active site 441770009489 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 441770009490 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 441770009491 Ligand Binding Site [chemical binding]; other site 441770009492 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 441770009493 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 441770009494 ring oligomerisation interface [polypeptide binding]; other site 441770009495 ATP/Mg binding site [chemical binding]; other site 441770009496 stacking interactions; other site 441770009497 hinge regions; other site 441770009498 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 441770009499 oligomerisation interface [polypeptide binding]; other site 441770009500 mobile loop; other site 441770009501 roof hairpin; other site 441770009502 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 441770009503 Uncharacterized conserved protein [Function unknown]; Region: COG0398 441770009504 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 441770009505 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 441770009506 4Fe-4S binding domain; Region: Fer4; pfam00037 441770009507 4Fe-4S binding domain; Region: Fer4; pfam00037 441770009508 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 441770009509 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 441770009510 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 441770009511 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 441770009512 minor groove reading motif; other site 441770009513 helix-hairpin-helix signature motif; other site 441770009514 substrate binding pocket [chemical binding]; other site 441770009515 active site 441770009516 putative oxidoreductase; Provisional; Region: PRK12831 441770009517 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 441770009518 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 441770009519 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 441770009520 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 441770009521 FAD binding pocket [chemical binding]; other site 441770009522 FAD binding motif [chemical binding]; other site 441770009523 phosphate binding motif [ion binding]; other site 441770009524 beta-alpha-beta structure motif; other site 441770009525 NAD binding pocket [chemical binding]; other site 441770009526 Iron coordination center [ion binding]; other site 441770009527 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 441770009528 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 441770009529 CoA binding domain; Region: CoA_binding; pfam02629 441770009530 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 441770009531 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441770009532 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441770009533 ABC transporter; Region: ABC_tran_2; pfam12848 441770009534 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441770009535 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 441770009536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770009537 active site 441770009538 phosphorylation site [posttranslational modification] 441770009539 intermolecular recognition site; other site 441770009540 dimerization interface [polypeptide binding]; other site 441770009541 LytTr DNA-binding domain; Region: LytTR; pfam04397 441770009542 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 441770009543 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 441770009544 Histidine kinase; Region: His_kinase; pfam06580 441770009545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770009546 ATP binding site [chemical binding]; other site 441770009547 Mg2+ binding site [ion binding]; other site 441770009548 G-X-G motif; other site 441770009549 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 441770009550 Carbon starvation protein CstA; Region: CstA; pfam02554 441770009551 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 441770009552 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 441770009553 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 441770009554 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 441770009555 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 441770009556 Peptidase M16C associated; Region: M16C_assoc; pfam08367 441770009557 pyruvate carboxylase; Reviewed; Region: PRK12999 441770009558 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 441770009559 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 441770009560 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 441770009561 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 441770009562 active site 441770009563 catalytic residues [active] 441770009564 metal binding site [ion binding]; metal-binding site 441770009565 homodimer binding site [polypeptide binding]; other site 441770009566 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 441770009567 carboxyltransferase (CT) interaction site; other site 441770009568 biotinylation site [posttranslational modification]; other site 441770009569 UGMP family protein; Validated; Region: PRK09604 441770009570 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 441770009571 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 441770009572 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 441770009573 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 441770009574 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 441770009575 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 441770009576 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 441770009577 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 441770009578 intersubunit interface [polypeptide binding]; other site 441770009579 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441770009580 Zn2+ binding site [ion binding]; other site 441770009581 Mg2+ binding site [ion binding]; other site 441770009582 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 441770009583 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441770009584 Zn2+ binding site [ion binding]; other site 441770009585 Mg2+ binding site [ion binding]; other site 441770009586 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 441770009587 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 441770009588 Glycoprotease family; Region: Peptidase_M22; pfam00814 441770009589 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 441770009590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441770009591 Coenzyme A binding pocket [chemical binding]; other site 441770009592 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 441770009593 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 441770009594 active site 441770009595 HIGH motif; other site 441770009596 dimer interface [polypeptide binding]; other site 441770009597 KMSKS motif; other site 441770009598 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441770009599 RNA binding surface [nucleotide binding]; other site 441770009600 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 441770009601 Divergent AAA domain; Region: AAA_4; pfam04326 441770009602 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 441770009603 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 441770009604 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 441770009605 active site 441770009606 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 441770009607 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 441770009608 G1 box; other site 441770009609 putative GEF interaction site [polypeptide binding]; other site 441770009610 GTP/Mg2+ binding site [chemical binding]; other site 441770009611 Switch I region; other site 441770009612 G2 box; other site 441770009613 G3 box; other site 441770009614 Switch II region; other site 441770009615 G4 box; other site 441770009616 G5 box; other site 441770009617 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 441770009618 sugar phosphate phosphatase; Provisional; Region: PRK10513 441770009619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441770009620 active site 441770009621 motif I; other site 441770009622 motif II; other site 441770009623 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 441770009624 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 441770009625 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 441770009626 active site 441770009627 HIGH motif; other site 441770009628 dimer interface [polypeptide binding]; other site 441770009629 KMSKS motif; other site 441770009630 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 441770009631 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 441770009632 non-heme iron binding site [ion binding]; other site 441770009633 dimer interface [polypeptide binding]; other site 441770009634 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 441770009635 non-heme iron binding site [ion binding]; other site 441770009636 dimer interface [polypeptide binding]; other site 441770009637 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 441770009638 Putative glucoamylase; Region: Glycoamylase; pfam10091 441770009639 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 441770009640 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 441770009641 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 441770009642 diaminopimelate decarboxylase; Region: lysA; TIGR01048 441770009643 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 441770009644 active site 441770009645 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441770009646 substrate binding site [chemical binding]; other site 441770009647 catalytic residues [active] 441770009648 dimer interface [polypeptide binding]; other site 441770009649 aspartate kinase; Reviewed; Region: PRK06635 441770009650 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 441770009651 putative nucleotide binding site [chemical binding]; other site 441770009652 putative catalytic residues [active] 441770009653 putative Mg ion binding site [ion binding]; other site 441770009654 putative aspartate binding site [chemical binding]; other site 441770009655 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 441770009656 putative allosteric regulatory site; other site 441770009657 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 441770009658 putative allosteric regulatory residue; other site 441770009659 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 441770009660 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 441770009661 active site 441770009662 metal binding site [ion binding]; metal-binding site 441770009663 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 441770009664 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 441770009665 hypothetical protein; Provisional; Region: PRK06851 441770009666 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 441770009667 Part of AAA domain; Region: AAA_19; pfam13245 441770009668 FtsH Extracellular; Region: FtsH_ext; pfam06480 441770009669 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 441770009670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770009671 Walker A motif; other site 441770009672 ATP binding site [chemical binding]; other site 441770009673 Walker B motif; other site 441770009674 arginine finger; other site 441770009675 Peptidase family M41; Region: Peptidase_M41; pfam01434 441770009676 dipeptidase PepV; Reviewed; Region: PRK07318 441770009677 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 441770009678 active site 441770009679 metal binding site [ion binding]; metal-binding site 441770009680 prolyl-tRNA synthetase; Provisional; Region: PRK08661 441770009681 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 441770009682 dimer interface [polypeptide binding]; other site 441770009683 motif 1; other site 441770009684 active site 441770009685 motif 2; other site 441770009686 motif 3; other site 441770009687 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 441770009688 anticodon binding site; other site 441770009689 zinc-binding site [ion binding]; other site 441770009690 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 441770009691 GIY-YIG motif/motif A; other site 441770009692 putative active site [active] 441770009693 putative metal binding site [ion binding]; other site 441770009694 putative transporter; Provisional; Region: PRK11660 441770009695 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 441770009696 Sulfate transporter family; Region: Sulfate_transp; pfam00916 441770009697 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 441770009698 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770009699 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 441770009700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770009701 dimer interface [polypeptide binding]; other site 441770009702 phosphorylation site [posttranslational modification] 441770009703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770009704 ATP binding site [chemical binding]; other site 441770009705 Mg2+ binding site [ion binding]; other site 441770009706 G-X-G motif; other site 441770009707 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770009708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770009709 active site 441770009710 phosphorylation site [posttranslational modification] 441770009711 intermolecular recognition site; other site 441770009712 dimerization interface [polypeptide binding]; other site 441770009713 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770009714 DNA binding site [nucleotide binding] 441770009715 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 441770009716 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 441770009717 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441770009718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770009719 Walker A/P-loop; other site 441770009720 ATP binding site [chemical binding]; other site 441770009721 Q-loop/lid; other site 441770009722 ABC transporter signature motif; other site 441770009723 Walker B; other site 441770009724 D-loop; other site 441770009725 H-loop/switch region; other site 441770009726 Uncharacterized conserved protein [Function unknown]; Region: COG3589 441770009727 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 441770009728 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 441770009729 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 441770009730 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 441770009731 methionine cluster; other site 441770009732 active site 441770009733 phosphorylation site [posttranslational modification] 441770009734 metal binding site [ion binding]; metal-binding site 441770009735 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 441770009736 active site 441770009737 P-loop; other site 441770009738 phosphorylation site [posttranslational modification] 441770009739 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 441770009740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770009741 Walker A motif; other site 441770009742 ATP binding site [chemical binding]; other site 441770009743 Walker B motif; other site 441770009744 arginine finger; other site 441770009745 Transcriptional antiterminator [Transcription]; Region: COG3933 441770009746 PRD domain; Region: PRD; pfam00874 441770009747 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 441770009748 active pocket/dimerization site; other site 441770009749 active site 441770009750 phosphorylation site [posttranslational modification] 441770009751 PRD domain; Region: PRD; pfam00874 441770009752 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 441770009753 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 441770009754 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 441770009755 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 441770009756 NAD binding site [chemical binding]; other site 441770009757 sugar binding site [chemical binding]; other site 441770009758 divalent metal binding site [ion binding]; other site 441770009759 tetramer (dimer of dimers) interface [polypeptide binding]; other site 441770009760 dimer interface [polypeptide binding]; other site 441770009761 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 441770009762 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441770009763 metal binding site [ion binding]; metal-binding site 441770009764 active site 441770009765 I-site; other site 441770009766 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 441770009767 active site 441770009768 catalytic residues [active] 441770009769 DNA binding site [nucleotide binding] 441770009770 Int/Topo IB signature motif; other site 441770009771 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 441770009772 Protein of unknown function DUF43; Region: DUF43; pfam01861 441770009773 Mor transcription activator family; Region: Mor; cl02360 441770009774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441770009775 NmrA-like family; Region: NmrA; pfam05368 441770009776 NAD(P) binding site [chemical binding]; other site 441770009777 active site 441770009778 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 441770009779 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 441770009780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441770009781 S-adenosylmethionine binding site [chemical binding]; other site 441770009782 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 441770009783 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 441770009784 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 441770009785 active site 441770009786 catalytic tetrad [active] 441770009787 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 441770009788 pyruvate kinase; Provisional; Region: PRK06354 441770009789 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 441770009790 domain interfaces; other site 441770009791 active site 441770009792 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 441770009793 6-phosphofructokinase; Provisional; Region: PRK03202 441770009794 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 441770009795 active site 441770009796 ADP/pyrophosphate binding site [chemical binding]; other site 441770009797 dimerization interface [polypeptide binding]; other site 441770009798 allosteric effector site; other site 441770009799 fructose-1,6-bisphosphate binding site; other site 441770009800 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 441770009801 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 441770009802 active site 441770009803 PHP Thumb interface [polypeptide binding]; other site 441770009804 metal binding site [ion binding]; metal-binding site 441770009805 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 441770009806 generic binding surface II; other site 441770009807 generic binding surface I; other site 441770009808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 441770009809 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 441770009810 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 441770009811 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 441770009812 phosphate binding site [ion binding]; other site 441770009813 putative substrate binding pocket [chemical binding]; other site 441770009814 dimer interface [polypeptide binding]; other site 441770009815 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 441770009816 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 441770009817 FAD binding domain; Region: FAD_binding_4; pfam01565 441770009818 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 441770009819 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 441770009820 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 441770009821 active site 441770009822 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 441770009823 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 441770009824 GIY-YIG motif/motif A; other site 441770009825 active site 441770009826 catalytic site [active] 441770009827 putative DNA binding site [nucleotide binding]; other site 441770009828 metal binding site [ion binding]; metal-binding site 441770009829 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 441770009830 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 441770009831 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 441770009832 generic binding surface II; other site 441770009833 generic binding surface I; other site 441770009834 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441770009835 Zn2+ binding site [ion binding]; other site 441770009836 Mg2+ binding site [ion binding]; other site 441770009837 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 441770009838 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 441770009839 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 441770009840 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 441770009841 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 441770009842 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 441770009843 phosphopeptide binding site; other site 441770009844 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 441770009845 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 441770009846 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 441770009847 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 441770009848 excinuclease ABC subunit B; Provisional; Region: PRK05298 441770009849 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441770009850 ATP binding site [chemical binding]; other site 441770009851 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441770009852 nucleotide binding region [chemical binding]; other site 441770009853 ATP-binding site [chemical binding]; other site 441770009854 Ultra-violet resistance protein B; Region: UvrB; pfam12344 441770009855 UvrB/uvrC motif; Region: UVR; pfam02151 441770009856 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 441770009857 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 441770009858 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 441770009859 C-terminal peptidase (prc); Region: prc; TIGR00225 441770009860 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 441770009861 protein binding site [polypeptide binding]; other site 441770009862 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 441770009863 Catalytic dyad [active] 441770009864 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 441770009865 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 441770009866 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 441770009867 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441770009868 Walker A/P-loop; other site 441770009869 ATP binding site [chemical binding]; other site 441770009870 Q-loop/lid; other site 441770009871 ABC transporter signature motif; other site 441770009872 Walker B; other site 441770009873 D-loop; other site 441770009874 H-loop/switch region; other site 441770009875 Uncharacterized conserved protein [Function unknown]; Region: COG1284 441770009876 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 441770009877 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 441770009878 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 441770009879 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 441770009880 PYR/PP interface [polypeptide binding]; other site 441770009881 dimer interface [polypeptide binding]; other site 441770009882 TPP binding site [chemical binding]; other site 441770009883 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 441770009884 transketolase; Reviewed; Region: PRK05899 441770009885 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 441770009886 TPP-binding site [chemical binding]; other site 441770009887 dimer interface [polypeptide binding]; other site 441770009888 PemK-like protein; Region: PemK; pfam02452 441770009889 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 441770009890 alanine racemase; Reviewed; Region: alr; PRK00053 441770009891 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 441770009892 active site 441770009893 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441770009894 dimer interface [polypeptide binding]; other site 441770009895 substrate binding site [chemical binding]; other site 441770009896 catalytic residues [active] 441770009897 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 441770009898 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 441770009899 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 441770009900 putative substrate binding site [chemical binding]; other site 441770009901 putative ATP binding site [chemical binding]; other site 441770009902 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 441770009903 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 441770009904 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 441770009905 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 441770009906 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 441770009907 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 441770009908 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 441770009909 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441770009910 RNA binding surface [nucleotide binding]; other site 441770009911 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 441770009912 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 441770009913 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 441770009914 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 441770009915 active site 441770009916 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 441770009917 dinuclear metal binding motif [ion binding]; other site 441770009918 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 441770009919 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 441770009920 glutaminase active site [active] 441770009921 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 441770009922 dimer interface [polypeptide binding]; other site 441770009923 active site 441770009924 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 441770009925 dimer interface [polypeptide binding]; other site 441770009926 active site 441770009927 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 441770009928 active site 441770009929 intersubunit interactions; other site 441770009930 catalytic residue [active] 441770009931 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 441770009932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441770009933 motif II; other site 441770009934 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 441770009935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441770009936 NAD(P) binding site [chemical binding]; other site 441770009937 active site 441770009938 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 441770009939 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 441770009940 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 441770009941 Nucleoside recognition; Region: Gate; pfam07670 441770009942 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 441770009943 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 441770009944 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 441770009945 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 441770009946 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 441770009947 putative NAD(P) binding site [chemical binding]; other site 441770009948 catalytic Zn binding site [ion binding]; other site 441770009949 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 441770009950 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 441770009951 non-specific DNA interactions [nucleotide binding]; other site 441770009952 DNA binding site [nucleotide binding] 441770009953 sequence specific DNA binding site [nucleotide binding]; other site 441770009954 putative cAMP binding site [chemical binding]; other site 441770009955 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 441770009956 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 441770009957 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 441770009958 active site 441770009959 substrate binding site [chemical binding]; other site 441770009960 metal binding site [ion binding]; metal-binding site 441770009961 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 441770009962 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 441770009963 dimer interface [polypeptide binding]; other site 441770009964 PYR/PP interface [polypeptide binding]; other site 441770009965 TPP binding site [chemical binding]; other site 441770009966 substrate binding site [chemical binding]; other site 441770009967 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 441770009968 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 441770009969 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 441770009970 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 441770009971 P-loop; other site 441770009972 Magnesium ion binding site [ion binding]; other site 441770009973 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 441770009974 nucleotide binding site [chemical binding]; other site 441770009975 Acetokinase family; Region: Acetate_kinase; cl17229 441770009976 phosphate butyryltransferase; Validated; Region: PRK05805 441770009977 butyrate kinase; Provisional; Region: PRK03011 441770009978 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 441770009979 YbbR-like protein; Region: YbbR; pfam07949 441770009980 YbbR-like protein; Region: YbbR; pfam07949 441770009981 Uncharacterized conserved protein [Function unknown]; Region: COG1624 441770009982 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 441770009983 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 441770009984 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 441770009985 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 441770009986 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 441770009987 catalytic residues [active] 441770009988 isoaspartyl dipeptidase; Provisional; Region: PRK10657 441770009989 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 441770009990 active site 441770009991 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 441770009992 TPR motif; other site 441770009993 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441770009994 binding surface 441770009995 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 441770009996 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 441770009997 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 441770009998 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 441770009999 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 441770010000 dimerization domain swap beta strand [polypeptide binding]; other site 441770010001 regulatory protein interface [polypeptide binding]; other site 441770010002 active site 441770010003 regulatory phosphorylation site [posttranslational modification]; other site 441770010004 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 441770010005 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441770010006 putative active site [active] 441770010007 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441770010008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770010009 Walker A motif; other site 441770010010 ATP binding site [chemical binding]; other site 441770010011 Walker B motif; other site 441770010012 arginine finger; other site 441770010013 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 441770010014 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441770010015 TPR motif; other site 441770010016 binding surface 441770010017 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441770010018 fumarate hydratase; Provisional; Region: PRK06842 441770010019 fumarate hydratase; Provisional; Region: PRK06246 441770010020 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 441770010021 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 441770010022 active site 441770010023 metal binding site [ion binding]; metal-binding site 441770010024 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 441770010025 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 441770010026 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 441770010027 PhoU domain; Region: PhoU; pfam01895 441770010028 PhoU domain; Region: PhoU; pfam01895 441770010029 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 441770010030 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 441770010031 23S rRNA interface [nucleotide binding]; other site 441770010032 L3 interface [polypeptide binding]; other site 441770010033 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 441770010034 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 441770010035 dimerization interface 3.5A [polypeptide binding]; other site 441770010036 active site 441770010037 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 441770010038 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 441770010039 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 441770010040 Walker A/P-loop; other site 441770010041 ATP binding site [chemical binding]; other site 441770010042 Q-loop/lid; other site 441770010043 ABC transporter signature motif; other site 441770010044 Walker B; other site 441770010045 D-loop; other site 441770010046 H-loop/switch region; other site 441770010047 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 441770010048 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 441770010049 Walker A/P-loop; other site 441770010050 ATP binding site [chemical binding]; other site 441770010051 Q-loop/lid; other site 441770010052 ABC transporter signature motif; other site 441770010053 Walker B; other site 441770010054 D-loop; other site 441770010055 H-loop/switch region; other site 441770010056 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 441770010057 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 441770010058 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 441770010059 alphaNTD homodimer interface [polypeptide binding]; other site 441770010060 alphaNTD - beta interaction site [polypeptide binding]; other site 441770010061 alphaNTD - beta' interaction site [polypeptide binding]; other site 441770010062 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 441770010063 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 441770010064 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 441770010065 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441770010066 RNA binding surface [nucleotide binding]; other site 441770010067 30S ribosomal protein S11; Validated; Region: PRK05309 441770010068 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 441770010069 30S ribosomal protein S13; Region: bact_S13; TIGR03631 441770010070 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 441770010071 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 441770010072 rRNA binding site [nucleotide binding]; other site 441770010073 predicted 30S ribosome binding site; other site 441770010074 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 441770010075 RNA binding site [nucleotide binding]; other site 441770010076 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 441770010077 active site 441770010078 adenylate kinase; Reviewed; Region: adk; PRK00279 441770010079 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 441770010080 AMP-binding site [chemical binding]; other site 441770010081 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 441770010082 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 441770010083 SecY translocase; Region: SecY; pfam00344 441770010084 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 441770010085 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 441770010086 23S rRNA binding site [nucleotide binding]; other site 441770010087 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 441770010088 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 441770010089 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 441770010090 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 441770010091 5S rRNA interface [nucleotide binding]; other site 441770010092 L27 interface [polypeptide binding]; other site 441770010093 23S rRNA interface [nucleotide binding]; other site 441770010094 L5 interface [polypeptide binding]; other site 441770010095 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 441770010096 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 441770010097 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 441770010098 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 441770010099 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 441770010100 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 441770010101 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 441770010102 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 441770010103 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 441770010104 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 441770010105 RNA binding site [nucleotide binding]; other site 441770010106 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 441770010107 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 441770010108 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 441770010109 23S rRNA interface [nucleotide binding]; other site 441770010110 putative translocon interaction site; other site 441770010111 signal recognition particle (SRP54) interaction site; other site 441770010112 L23 interface [polypeptide binding]; other site 441770010113 trigger factor interaction site; other site 441770010114 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 441770010115 23S rRNA interface [nucleotide binding]; other site 441770010116 5S rRNA interface [nucleotide binding]; other site 441770010117 putative antibiotic binding site [chemical binding]; other site 441770010118 L25 interface [polypeptide binding]; other site 441770010119 L27 interface [polypeptide binding]; other site 441770010120 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 441770010121 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 441770010122 G-X-X-G motif; other site 441770010123 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 441770010124 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 441770010125 putative translocon binding site; other site 441770010126 protein-rRNA interface [nucleotide binding]; other site 441770010127 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 441770010128 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 441770010129 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 441770010130 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 441770010131 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 441770010132 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 441770010133 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 441770010134 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 441770010135 elongation factor Tu; Reviewed; Region: PRK00049 441770010136 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 441770010137 G1 box; other site 441770010138 GEF interaction site [polypeptide binding]; other site 441770010139 GTP/Mg2+ binding site [chemical binding]; other site 441770010140 Switch I region; other site 441770010141 G2 box; other site 441770010142 G3 box; other site 441770010143 Switch II region; other site 441770010144 G4 box; other site 441770010145 G5 box; other site 441770010146 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 441770010147 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 441770010148 Antibiotic Binding Site [chemical binding]; other site 441770010149 elongation factor G; Reviewed; Region: PRK00007 441770010150 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 441770010151 G1 box; other site 441770010152 putative GEF interaction site [polypeptide binding]; other site 441770010153 GTP/Mg2+ binding site [chemical binding]; other site 441770010154 Switch I region; other site 441770010155 G2 box; other site 441770010156 G3 box; other site 441770010157 Switch II region; other site 441770010158 G4 box; other site 441770010159 G5 box; other site 441770010160 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 441770010161 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 441770010162 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 441770010163 30S ribosomal protein S7; Validated; Region: PRK05302 441770010164 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 441770010165 S17 interaction site [polypeptide binding]; other site 441770010166 S8 interaction site; other site 441770010167 16S rRNA interaction site [nucleotide binding]; other site 441770010168 streptomycin interaction site [chemical binding]; other site 441770010169 23S rRNA interaction site [nucleotide binding]; other site 441770010170 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 441770010171 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 441770010172 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 441770010173 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 441770010174 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 441770010175 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 441770010176 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 441770010177 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 441770010178 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 441770010179 G-loop; other site 441770010180 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 441770010181 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 441770010182 DNA binding site [nucleotide binding] 441770010183 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 441770010184 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 441770010185 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 441770010186 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 441770010187 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 441770010188 RPB1 interaction site [polypeptide binding]; other site 441770010189 RPB10 interaction site [polypeptide binding]; other site 441770010190 RPB11 interaction site [polypeptide binding]; other site 441770010191 RPB3 interaction site [polypeptide binding]; other site 441770010192 RPB12 interaction site [polypeptide binding]; other site 441770010193 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 441770010194 core dimer interface [polypeptide binding]; other site 441770010195 peripheral dimer interface [polypeptide binding]; other site 441770010196 L10 interface [polypeptide binding]; other site 441770010197 L11 interface [polypeptide binding]; other site 441770010198 putative EF-Tu interaction site [polypeptide binding]; other site 441770010199 putative EF-G interaction site [polypeptide binding]; other site 441770010200 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 441770010201 23S rRNA interface [nucleotide binding]; other site 441770010202 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 441770010203 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 441770010204 mRNA/rRNA interface [nucleotide binding]; other site 441770010205 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 441770010206 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 441770010207 23S rRNA interface [nucleotide binding]; other site 441770010208 L7/L12 interface [polypeptide binding]; other site 441770010209 putative thiostrepton binding site; other site 441770010210 L25 interface [polypeptide binding]; other site 441770010211 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 441770010212 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 441770010213 putative homodimer interface [polypeptide binding]; other site 441770010214 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 441770010215 heterodimer interface [polypeptide binding]; other site 441770010216 homodimer interface [polypeptide binding]; other site 441770010217 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 441770010218 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 441770010219 elongation factor Tu; Reviewed; Region: PRK00049 441770010220 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 441770010221 G1 box; other site 441770010222 GEF interaction site [polypeptide binding]; other site 441770010223 GTP/Mg2+ binding site [chemical binding]; other site 441770010224 Switch I region; other site 441770010225 G2 box; other site 441770010226 G3 box; other site 441770010227 Switch II region; other site 441770010228 G4 box; other site 441770010229 G5 box; other site 441770010230 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 441770010231 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 441770010232 Antibiotic Binding Site [chemical binding]; other site 441770010233 RNA polymerase factor sigma-70; Validated; Region: PRK08295 441770010234 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441770010235 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 441770010236 YacP-like NYN domain; Region: NYN_YacP; pfam05991 441770010237 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 441770010238 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 441770010239 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 441770010240 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 441770010241 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 441770010242 dimerization interface [polypeptide binding]; other site 441770010243 active site 441770010244 metal binding site [ion binding]; metal-binding site 441770010245 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 441770010246 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 441770010247 active site 441770010248 HIGH motif; other site 441770010249 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 441770010250 KMSKS motif; other site 441770010251 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 441770010252 tRNA binding surface [nucleotide binding]; other site 441770010253 anticodon binding site; other site 441770010254 threonine dehydratase; Provisional; Region: PRK08198 441770010255 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 441770010256 tetramer interface [polypeptide binding]; other site 441770010257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441770010258 catalytic residue [active] 441770010259 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 441770010260 prolyl-tRNA synthetase; Provisional; Region: PRK09194 441770010261 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 441770010262 motif 1; other site 441770010263 dimer interface [polypeptide binding]; other site 441770010264 active site 441770010265 motif 2; other site 441770010266 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 441770010267 putative deacylase active site [active] 441770010268 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 441770010269 anticodon binding site; other site 441770010270 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 441770010271 substrate binding site; other site 441770010272 dimer interface; other site 441770010273 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 441770010274 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 441770010275 putative active site [active] 441770010276 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 441770010277 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 441770010278 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 441770010279 DNA repair protein RadA; Provisional; Region: PRK11823 441770010280 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 441770010281 Walker A motif/ATP binding site; other site 441770010282 ATP binding site [chemical binding]; other site 441770010283 Walker B motif; other site 441770010284 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 441770010285 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 441770010286 Clp amino terminal domain; Region: Clp_N; pfam02861 441770010287 Clp amino terminal domain; Region: Clp_N; pfam02861 441770010288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770010289 Walker A motif; other site 441770010290 ATP binding site [chemical binding]; other site 441770010291 Walker B motif; other site 441770010292 arginine finger; other site 441770010293 UvrB/uvrC motif; Region: UVR; pfam02151 441770010294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770010295 Walker A motif; other site 441770010296 ATP binding site [chemical binding]; other site 441770010297 Walker B motif; other site 441770010298 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 441770010299 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 441770010300 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 441770010301 ADP binding site [chemical binding]; other site 441770010302 phosphagen binding site; other site 441770010303 substrate specificity loop; other site 441770010304 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 441770010305 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 441770010306 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 441770010307 elongation factor G; Reviewed; Region: PRK12740 441770010308 G1 box; other site 441770010309 putative GEF interaction site [polypeptide binding]; other site 441770010310 GTP/Mg2+ binding site [chemical binding]; other site 441770010311 Switch I region; other site 441770010312 G2 box; other site 441770010313 G3 box; other site 441770010314 Switch II region; other site 441770010315 G4 box; other site 441770010316 G5 box; other site 441770010317 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 441770010318 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 441770010319 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 441770010320 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 441770010321 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 441770010322 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441770010323 Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729 441770010324 glycyl-tRNA synthetase; Provisional; Region: PRK04173 441770010325 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 441770010326 motif 1; other site 441770010327 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 441770010328 active site 441770010329 motif 2; other site 441770010330 motif 3; other site 441770010331 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 441770010332 anticodon binding site; other site 441770010333 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 441770010334 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 441770010335 dimer interface [polypeptide binding]; other site 441770010336 putative anticodon binding site; other site 441770010337 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 441770010338 motif 1; other site 441770010339 active site 441770010340 motif 2; other site 441770010341 motif 3; other site 441770010342 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 441770010343 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 441770010344 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 441770010345 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 441770010346 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 441770010347 FMN binding site [chemical binding]; other site 441770010348 active site 441770010349 catalytic residues [active] 441770010350 substrate binding site [chemical binding]; other site 441770010351 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 441770010352 nucleotide binding site [chemical binding]; other site 441770010353 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 441770010354 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 441770010355 Potassium binding sites [ion binding]; other site 441770010356 Cesium cation binding sites [ion binding]; other site 441770010357 FtsH Extracellular; Region: FtsH_ext; pfam06480 441770010358 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 441770010359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770010360 Walker A motif; other site 441770010361 ATP binding site [chemical binding]; other site 441770010362 Walker B motif; other site 441770010363 arginine finger; other site 441770010364 Peptidase family M41; Region: Peptidase_M41; pfam01434 441770010365 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441770010366 active site 441770010367 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 441770010368 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 441770010369 Ligand Binding Site [chemical binding]; other site 441770010370 TilS substrate C-terminal domain; Region: TilS_C; smart00977 441770010371 stage II sporulation protein E; Region: spore_II_E; TIGR02865 441770010372 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 441770010373 hypothetical protein; Provisional; Region: PRK05807 441770010374 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 441770010375 RNA binding site [nucleotide binding]; other site 441770010376 Septum formation initiator; Region: DivIC; pfam04977 441770010377 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 441770010378 sporulation protein YabP; Region: spore_yabP; TIGR02892 441770010379 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441770010380 RNA binding surface [nucleotide binding]; other site 441770010381 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 441770010382 IHF dimer interface [polypeptide binding]; other site 441770010383 IHF - DNA interface [nucleotide binding]; other site 441770010384 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 441770010385 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 441770010386 putative SAM binding site [chemical binding]; other site 441770010387 putative homodimer interface [polypeptide binding]; other site 441770010388 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 441770010389 homodimer interface [polypeptide binding]; other site 441770010390 metal binding site [ion binding]; metal-binding site 441770010391 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 441770010392 homodimer interface [polypeptide binding]; other site 441770010393 active site 441770010394 putative chemical substrate binding site [chemical binding]; other site 441770010395 metal binding site [ion binding]; metal-binding site 441770010396 stage V sporulation protein B; Region: spore_V_B; TIGR02900 441770010397 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 441770010398 stage V sporulation protein T; Region: spore_V_T; TIGR02851 441770010399 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 441770010400 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 441770010401 SurA N-terminal domain; Region: SurA_N_3; cl07813 441770010402 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 441770010403 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 441770010404 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 441770010405 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441770010406 ATP binding site [chemical binding]; other site 441770010407 putative Mg++ binding site [ion binding]; other site 441770010408 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441770010409 nucleotide binding region [chemical binding]; other site 441770010410 ATP-binding site [chemical binding]; other site 441770010411 TRCF domain; Region: TRCF; pfam03461 441770010412 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 441770010413 putative active site [active] 441770010414 catalytic residue [active] 441770010415 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 441770010416 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 441770010417 protein binding site [polypeptide binding]; other site 441770010418 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441770010419 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441770010420 dimerization interface [polypeptide binding]; other site 441770010421 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441770010422 dimer interface [polypeptide binding]; other site 441770010423 phosphorylation site [posttranslational modification] 441770010424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441770010425 ATP binding site [chemical binding]; other site 441770010426 Mg2+ binding site [ion binding]; other site 441770010427 G-X-G motif; other site 441770010428 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441770010429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441770010430 active site 441770010431 phosphorylation site [posttranslational modification] 441770010432 intermolecular recognition site; other site 441770010433 dimerization interface [polypeptide binding]; other site 441770010434 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441770010435 DNA binding site [nucleotide binding] 441770010436 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 441770010437 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 441770010438 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441770010439 active site 441770010440 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 441770010441 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 441770010442 Substrate binding site; other site 441770010443 Mg++ binding site; other site 441770010444 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 441770010445 active site 441770010446 substrate binding site [chemical binding]; other site 441770010447 CoA binding site [chemical binding]; other site 441770010448 regulatory protein SpoVG; Reviewed; Region: PRK13259 441770010449 pur operon repressor; Provisional; Region: PRK09213 441770010450 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 441770010451 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441770010452 active site 441770010453 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 441770010454 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 441770010455 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441770010456 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441770010457 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 441770010458 4Fe-4S binding domain; Region: Fer4; pfam00037 441770010459 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 441770010460 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 441770010461 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 441770010462 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441770010463 motif II; other site 441770010464 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 441770010465 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 441770010466 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 441770010467 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770010468 FeS/SAM binding site; other site 441770010469 Uncharacterized membrane protein [Function unknown]; Region: COG3949 441770010470 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313 441770010471 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770010472 FeS/SAM binding site; other site 441770010473 Heme NO binding; Region: HNOB; pfam07700 441770010474 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441770010475 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441770010476 dimer interface [polypeptide binding]; other site 441770010477 putative CheW interface [polypeptide binding]; other site 441770010478 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441770010479 non-specific DNA binding site [nucleotide binding]; other site 441770010480 salt bridge; other site 441770010481 sequence-specific DNA binding site [nucleotide binding]; other site 441770010482 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 441770010483 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 441770010484 active site 441770010485 glutamate racemase; Provisional; Region: PRK00865 441770010486 glutamine synthetase, type I; Region: GlnA; TIGR00653 441770010487 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 441770010488 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 441770010489 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 441770010490 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 441770010491 hinge; other site 441770010492 active site 441770010493 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 441770010494 Sporulation and spore germination; Region: Germane; pfam10646 441770010495 hypothetical protein; Provisional; Region: PRK05590 441770010496 SEC-C motif; Region: SEC-C; pfam02810 441770010497 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 441770010498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441770010499 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441770010500 putative substrate translocation pore; other site 441770010501 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 441770010502 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 441770010503 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441770010504 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441770010505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770010506 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441770010507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441770010508 methionine aminopeptidase; Provisional; Region: PRK12318 441770010509 SEC-C motif; Region: SEC-C; pfam02810 441770010510 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 441770010511 active site 441770010512 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 441770010513 putative FMN binding site [chemical binding]; other site 441770010514 glycine radical enzyme, YjjI family; Region: glycyl_YjjI; TIGR04040 441770010515 Pyruvate formate lyase; Region: PFL; pfam02901 441770010516 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 441770010517 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 441770010518 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 441770010519 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 441770010520 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770010521 FeS/SAM binding site; other site 441770010522 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 441770010523 VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal...; Region: VHS_ENTH_ANTH; cl02544 441770010524 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441770010525 FeS/SAM binding site; other site 441770010526 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 441770010527 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 441770010528 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 441770010529 G1 box; other site 441770010530 GTP/Mg2+ binding site [chemical binding]; other site 441770010531 Switch I region; other site 441770010532 G2 box; other site 441770010533 Switch II region; other site 441770010534 G3 box; other site 441770010535 G4 box; other site 441770010536 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 441770010537 Na binding site [ion binding]; other site 441770010538 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441770010539 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441770010540 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 441770010541 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 441770010542 active site 441770010543 PHP-associated; Region: PHP_C; pfam13263 441770010544 dUTPase; Region: dUTPase_2; pfam08761 441770010545 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 441770010546 active site 441770010547 homodimer interface [polypeptide binding]; other site 441770010548 metal binding site [ion binding]; metal-binding site 441770010549 Protein of unknown function, DUF606; Region: DUF606; pfam04657 441770010550 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441770010551 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441770010552 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 441770010553 dimerization interface [polypeptide binding]; other site 441770010554 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 441770010555 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 441770010556 active site 441770010557 catalytic residues [active] 441770010558 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 441770010559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441770010560 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 441770010561 putative dimerization interface [polypeptide binding]; other site 441770010562 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 441770010563 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 441770010564 putative ligand binding site [chemical binding]; other site 441770010565 NAD binding site [chemical binding]; other site 441770010566 catalytic site [active] 441770010567 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 441770010568 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 441770010569 Elongation factor 1 gamma, conserved domain; Region: EF1G; pfam00647 441770010570 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 441770010571 biotin carboxylase; Validated; Region: PRK05586 441770010572 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 441770010573 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 441770010574 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 441770010575 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 441770010576 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 441770010577 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 441770010578 carboxyltransferase (CT) interaction site; other site 441770010579 biotinylation site [posttranslational modification]; other site 441770010580 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 441770010581 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 441770010582 dimer interface [polypeptide binding]; other site 441770010583 active site 441770010584 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 441770010585 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 441770010586 NAD(P) binding site [chemical binding]; other site 441770010587 homotetramer interface [polypeptide binding]; other site 441770010588 homodimer interface [polypeptide binding]; other site 441770010589 active site 441770010590 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 441770010591 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 441770010592 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 441770010593 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 441770010594 FMN binding site [chemical binding]; other site 441770010595 substrate binding site [chemical binding]; other site 441770010596 putative catalytic residue [active] 441770010597 acyl carrier protein; Provisional; Region: acpP; PRK00982 441770010598 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 441770010599 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 441770010600 dimer interface [polypeptide binding]; other site 441770010601 active site 441770010602 CoA binding pocket [chemical binding]; other site 441770010603 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441770010604 MarR family; Region: MarR_2; pfam12802 441770010605 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 441770010606 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 441770010607 FMN binding site [chemical binding]; other site 441770010608 substrate binding site [chemical binding]; other site 441770010609 putative catalytic residue [active] 441770010610 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 441770010611 Peptidase family M23; Region: Peptidase_M23; pfam01551 441770010612 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 441770010613 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 441770010614 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 441770010615 DNA replication protein DnaC; Validated; Region: PRK06835 441770010616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770010617 Walker A motif; other site 441770010618 ATP binding site [chemical binding]; other site 441770010619 PEP synthetase regulatory protein; Provisional; Region: PRK05339 441770010620 CoA binding domain; Region: CoA_binding_2; pfam13380 441770010621 flavoprotein, HI0933 family; Region: TIGR00275 441770010622 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 441770010623 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 441770010624 active site 441770010625 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 441770010626 active site 441770010627 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 441770010628 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 441770010629 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 441770010630 GDP-binding site [chemical binding]; other site 441770010631 ACT binding site; other site 441770010632 IMP binding site; other site 441770010633 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 441770010634 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 441770010635 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 441770010636 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 441770010637 active site 441770010638 substrate binding site [chemical binding]; other site 441770010639 metal binding site [ion binding]; metal-binding site 441770010640 replicative DNA helicase; Provisional; Region: PRK05595 441770010641 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 441770010642 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 441770010643 Walker A motif; other site 441770010644 ATP binding site [chemical binding]; other site 441770010645 Walker B motif; other site 441770010646 DNA binding loops [nucleotide binding] 441770010647 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 441770010648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441770010649 Walker A motif; other site 441770010650 ATP binding site [chemical binding]; other site 441770010651 Walker B motif; other site 441770010652 arginine finger; other site 441770010653 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 441770010654 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 441770010655 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 441770010656 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 441770010657 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 441770010658 DHH family; Region: DHH; pfam01368 441770010659 DHHA1 domain; Region: DHHA1; pfam02272 441770010660 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 441770010661 MazG-like family; Region: MazG-like; pfam12643 441770010662 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 441770010663 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 441770010664 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 441770010665 dimer interface [polypeptide binding]; other site 441770010666 ssDNA binding site [nucleotide binding]; other site 441770010667 tetramer (dimer of dimers) interface [polypeptide binding]; other site 441770010668 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 441770010669 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 441770010670 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441770010671 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 441770010672 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 441770010673 Mechanosensitive ion channel; Region: MS_channel; pfam00924 441770010674 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 441770010675 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 441770010676 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 441770010677 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441770010678 catalytic residue [active] 441770010679 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 441770010680 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 441770010681 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 441770010682 ParB-like nuclease domain; Region: ParB; smart00470 441770010683 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 441770010684 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 441770010685 P-loop; other site 441770010686 Magnesium ion binding site [ion binding]; other site 441770010687 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 441770010688 Magnesium ion binding site [ion binding]; other site 441770010689 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 441770010690 ParB-like nuclease domain; Region: ParBc; pfam02195 441770010691 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 441770010692 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 441770010693 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 441770010694 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 441770010695 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 441770010696 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 441770010697 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 441770010698 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 441770010699 trmE is a tRNA modification GTPase; Region: trmE; cd04164 441770010700 G1 box; other site 441770010701 GTP/Mg2+ binding site [chemical binding]; other site 441770010702 Switch I region; other site 441770010703 G2 box; other site 441770010704 Switch II region; other site 441770010705 G3 box; other site 441770010706 G4 box; other site 441770010707 G5 box; other site 441770010708 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 441770010709 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 441770010710 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 441770010711 G-X-X-G motif; other site 441770010712 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 441770010713 RxxxH motif; other site 441770010714 putative inner membrane protein translocase component YidC; Provisional; Region: PRK00145 441770010715 Haemolytic domain; Region: Haemolytic; pfam01809 441770010716 ribonuclease P; Reviewed; Region: rnpA; PRK00499 441770010717 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399