-- dump date 20140619_043505 -- class Genbank::misc_feature -- table misc_feature_note -- id note 508767000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 508767000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 508767000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767000004 Walker A motif; other site 508767000005 ATP binding site [chemical binding]; other site 508767000006 Walker B motif; other site 508767000007 arginine finger; other site 508767000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 508767000009 DnaA box-binding interface [nucleotide binding]; other site 508767000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 508767000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 508767000012 putative DNA binding surface [nucleotide binding]; other site 508767000013 dimer interface [polypeptide binding]; other site 508767000014 beta-clamp/clamp loader binding surface; other site 508767000015 beta-clamp/translesion DNA polymerase binding surface; other site 508767000016 S4 domain; Region: S4_2; cl17325 508767000017 recombination protein F; Reviewed; Region: recF; PRK00064 508767000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 508767000019 Walker A/P-loop; other site 508767000020 ATP binding site [chemical binding]; other site 508767000021 Q-loop/lid; other site 508767000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767000023 ABC transporter signature motif; other site 508767000024 Walker B; other site 508767000025 D-loop; other site 508767000026 H-loop/switch region; other site 508767000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 508767000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767000029 Mg2+ binding site [ion binding]; other site 508767000030 G-X-G motif; other site 508767000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 508767000032 anchoring element; other site 508767000033 dimer interface [polypeptide binding]; other site 508767000034 ATP binding site [chemical binding]; other site 508767000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 508767000036 active site 508767000037 putative metal-binding site [ion binding]; other site 508767000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 508767000039 DNA gyrase subunit A; Validated; Region: PRK05560 508767000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 508767000041 CAP-like domain; other site 508767000042 active site 508767000043 primary dimer interface [polypeptide binding]; other site 508767000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508767000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508767000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508767000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508767000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508767000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508767000050 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508767000051 Zn2+ binding site [ion binding]; other site 508767000052 Mg2+ binding site [ion binding]; other site 508767000053 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 508767000054 HTH domain; Region: HTH_11; pfam08279 508767000055 3H domain; Region: 3H; pfam02829 508767000056 hydroxyglutarate oxidase; Provisional; Region: PRK11728 508767000057 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 508767000058 Protein of unknown function (DUF1667); Region: DUF1667; cl17602 508767000059 T-box leader 508767000060 seryl-tRNA synthetase; Provisional; Region: PRK05431 508767000061 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 508767000062 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 508767000063 dimer interface [polypeptide binding]; other site 508767000064 active site 508767000065 motif 1; other site 508767000066 motif 2; other site 508767000067 motif 3; other site 508767000068 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 508767000069 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 508767000070 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 508767000071 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 508767000072 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 508767000073 Part of AAA domain; Region: AAA_19; pfam13245 508767000074 Family description; Region: UvrD_C_2; pfam13538 508767000075 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 508767000076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 508767000077 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 508767000078 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 508767000079 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 508767000080 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 508767000081 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767000082 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767000083 dimer interface [polypeptide binding]; other site 508767000084 phosphorylation site [posttranslational modification] 508767000085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767000086 ATP binding site [chemical binding]; other site 508767000087 Mg2+ binding site [ion binding]; other site 508767000088 G-X-G motif; other site 508767000089 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 508767000090 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 508767000091 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 508767000092 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 508767000093 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 508767000094 catalytic loop [active] 508767000095 iron binding site [ion binding]; other site 508767000096 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 508767000097 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 508767000098 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 508767000099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767000100 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508767000101 active site 508767000102 motif I; other site 508767000103 motif II; other site 508767000104 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 508767000105 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508767000106 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508767000107 ABC transporter; Region: ABC_tran_2; pfam12848 508767000108 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508767000109 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 508767000110 Na2 binding site [ion binding]; other site 508767000111 putative substrate binding site 1 [chemical binding]; other site 508767000112 Na binding site 1 [ion binding]; other site 508767000113 putative substrate binding site 2 [chemical binding]; other site 508767000114 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 508767000115 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 508767000116 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 508767000117 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 508767000118 PemK-like protein; Region: PemK; pfam02452 508767000119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 508767000120 Nucleoside recognition; Region: Gate; pfam07670 508767000121 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 508767000122 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 508767000123 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767000124 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767000125 dimer interface [polypeptide binding]; other site 508767000126 putative CheW interface [polypeptide binding]; other site 508767000127 gamma-glutamyl kinase; Provisional; Region: PRK05429 508767000128 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 508767000129 nucleotide binding site [chemical binding]; other site 508767000130 homotetrameric interface [polypeptide binding]; other site 508767000131 putative phosphate binding site [ion binding]; other site 508767000132 putative allosteric binding site; other site 508767000133 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 508767000134 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 508767000135 putative catalytic cysteine [active] 508767000136 Autoinducer synthetase; Region: Autoind_synth; cl17404 508767000137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767000138 Coenzyme A binding pocket [chemical binding]; other site 508767000139 Bacterial PH domain; Region: DUF304; cl01348 508767000140 Predicted membrane protein [Function unknown]; Region: COG3428 508767000141 Bacterial PH domain; Region: DUF304; pfam03703 508767000142 Bacterial PH domain; Region: DUF304; cl01348 508767000143 short chain dehydrogenase; Provisional; Region: PRK08251 508767000144 classical (c) SDRs; Region: SDR_c; cd05233 508767000145 NAD(P) binding site [chemical binding]; other site 508767000146 active site 508767000147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767000148 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508767000149 active site 508767000150 motif I; other site 508767000151 motif II; other site 508767000152 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767000153 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767000154 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767000155 dimer interface [polypeptide binding]; other site 508767000156 putative CheW interface [polypeptide binding]; other site 508767000157 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 508767000158 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 508767000159 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 508767000160 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 508767000161 catalytic site [active] 508767000162 subunit interface [polypeptide binding]; other site 508767000163 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 508767000164 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 508767000165 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 508767000166 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 508767000167 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 508767000168 ATP-grasp domain; Region: ATP-grasp_4; cl17255 508767000169 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 508767000170 IMP binding site; other site 508767000171 dimer interface [polypeptide binding]; other site 508767000172 interdomain contacts; other site 508767000173 partial ornithine binding site; other site 508767000174 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 508767000175 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508767000176 Zn2+ binding site [ion binding]; other site 508767000177 Mg2+ binding site [ion binding]; other site 508767000178 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 508767000179 glutamate racemase; Provisional; Region: PRK00865 508767000180 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 508767000181 active site 508767000182 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 508767000183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508767000184 non-specific DNA binding site [nucleotide binding]; other site 508767000185 salt bridge; other site 508767000186 sequence-specific DNA binding site [nucleotide binding]; other site 508767000187 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 508767000188 Catalytic site [active] 508767000189 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 508767000190 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508767000191 active site 508767000192 catalytic triad [active] 508767000193 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508767000194 active site 508767000195 catalytic triad [active] 508767000196 Stage II sporulation protein; Region: SpoIID; pfam08486 508767000197 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 508767000198 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 508767000199 Radical SAM superfamily; Region: Radical_SAM; pfam04055 508767000200 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767000201 FeS/SAM binding site; other site 508767000202 Uncharacterized membrane protein [Function unknown]; Region: COG3949 508767000203 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 508767000204 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 508767000205 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 508767000206 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 508767000207 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 508767000208 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 508767000209 putative RNA binding site [nucleotide binding]; other site 508767000210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767000211 S-adenosylmethionine binding site [chemical binding]; other site 508767000212 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 508767000213 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767000214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767000215 active site 508767000216 phosphorylation site [posttranslational modification] 508767000217 intermolecular recognition site; other site 508767000218 dimerization interface [polypeptide binding]; other site 508767000219 DNA binding site [nucleotide binding] 508767000220 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 508767000221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767000222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767000223 dimer interface [polypeptide binding]; other site 508767000224 phosphorylation site [posttranslational modification] 508767000225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767000226 ATP binding site [chemical binding]; other site 508767000227 Mg2+ binding site [ion binding]; other site 508767000228 G-X-G motif; other site 508767000229 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 508767000230 putative metal binding residues [ion binding]; other site 508767000231 signature motif; other site 508767000232 dimer interface [polypeptide binding]; other site 508767000233 active site 508767000234 polyP binding site; other site 508767000235 substrate binding site [chemical binding]; other site 508767000236 acceptor-phosphate pocket; other site 508767000237 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 508767000238 MgtC family; Region: MgtC; pfam02308 508767000239 CotH protein; Region: CotH; pfam08757 508767000240 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 508767000241 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 508767000242 active site 508767000243 metal binding site [ion binding]; metal-binding site 508767000244 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 508767000245 T-box leader 508767000246 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 508767000247 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 508767000248 HIGH motif; other site 508767000249 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 508767000250 active site 508767000251 KMSKS motif; other site 508767000252 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 508767000253 tRNA binding surface [nucleotide binding]; other site 508767000254 anticodon binding site; other site 508767000255 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508767000256 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508767000257 DNA binding site [nucleotide binding] 508767000258 domain linker motif; other site 508767000259 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 508767000260 dimerization interface [polypeptide binding]; other site 508767000261 ligand binding site [chemical binding]; other site 508767000262 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508767000263 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 508767000264 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 508767000265 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 508767000266 Uncharacterized conserved protein [Function unknown]; Region: COG3937 508767000267 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 508767000268 ABC1 family; Region: ABC1; cl17513 508767000269 Lysine riboswitch 508767000270 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 508767000271 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 508767000272 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 508767000273 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 508767000274 active site 508767000275 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 508767000276 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 508767000277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767000278 Walker A motif; other site 508767000279 ATP binding site [chemical binding]; other site 508767000280 Walker B motif; other site 508767000281 arginine finger; other site 508767000282 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 508767000283 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 508767000284 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 508767000285 amphipathic channel; other site 508767000286 Asn-Pro-Ala signature motifs; other site 508767000287 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 508767000288 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 508767000289 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 508767000290 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 508767000291 active pocket/dimerization site; other site 508767000292 active site 508767000293 phosphorylation site [posttranslational modification] 508767000294 T-box leader 508767000295 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 508767000296 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 508767000297 HIGH motif; other site 508767000298 active site 508767000299 KMSKS motif; other site 508767000300 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 508767000301 tRNA binding surface [nucleotide binding]; other site 508767000302 anticodon binding site; other site 508767000303 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 508767000304 dimer interface [polypeptide binding]; other site 508767000305 putative tRNA-binding site [nucleotide binding]; other site 508767000306 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 508767000307 active site 508767000308 Domain of unknown function (DUF348); Region: DUF348; pfam03990 508767000309 G5 domain; Region: G5; pfam07501 508767000310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 508767000311 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 508767000312 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 508767000313 putative active site [active] 508767000314 putative metal binding site [ion binding]; other site 508767000315 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 508767000316 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 508767000317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767000318 S-adenosylmethionine binding site [chemical binding]; other site 508767000319 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 508767000320 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 508767000321 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 508767000322 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 508767000323 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 508767000324 Predicted transcriptional regulators [Transcription]; Region: COG1695 508767000325 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 508767000326 EDD domain protein, DegV family; Region: DegV; TIGR00762 508767000327 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 508767000328 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 508767000329 ATP cone domain; Region: ATP-cone; pfam03477 508767000330 Class III ribonucleotide reductase; Region: RNR_III; cd01675 508767000331 effector binding site; other site 508767000332 active site 508767000333 Zn binding site [ion binding]; other site 508767000334 glycine loop; other site 508767000335 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 508767000336 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 508767000337 active site 508767000338 catalytic residues [active] 508767000339 metal binding site [ion binding]; metal-binding site 508767000340 aconitate hydratase; Validated; Region: PRK07229 508767000341 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 508767000342 substrate binding site [chemical binding]; other site 508767000343 ligand binding site [chemical binding]; other site 508767000344 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 508767000345 substrate binding site [chemical binding]; other site 508767000346 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508767000347 metal binding site [ion binding]; metal-binding site 508767000348 active site 508767000349 I-site; other site 508767000350 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 508767000351 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 508767000352 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767000353 FeS/SAM binding site; other site 508767000354 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 508767000355 active site 508767000356 DNA binding site [nucleotide binding] 508767000357 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508767000358 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508767000359 DNA binding site [nucleotide binding] 508767000360 domain linker motif; other site 508767000361 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 508767000362 dimerization interface [polypeptide binding]; other site 508767000363 ligand binding site [chemical binding]; other site 508767000364 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 508767000365 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 508767000366 Ca binding site [ion binding]; other site 508767000367 active site 508767000368 catalytic site [active] 508767000369 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 508767000370 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 508767000371 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 508767000372 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 508767000373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767000374 dimer interface [polypeptide binding]; other site 508767000375 conserved gate region; other site 508767000376 putative PBP binding loops; other site 508767000377 ABC-ATPase subunit interface; other site 508767000378 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 508767000379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767000380 dimer interface [polypeptide binding]; other site 508767000381 conserved gate region; other site 508767000382 putative PBP binding loops; other site 508767000383 ABC-ATPase subunit interface; other site 508767000384 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 508767000385 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 508767000386 putative active site [active] 508767000387 putative metal binding site [ion binding]; other site 508767000388 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 508767000389 Phage capsid family; Region: Phage_capsid; pfam05065 508767000390 Helix-turn-helix domain; Region: HTH_38; pfam13936 508767000391 Winged helix-turn helix; Region: HTH_29; pfam13551 508767000392 DNA-binding interface [nucleotide binding]; DNA binding site 508767000393 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 508767000394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508767000395 non-specific DNA binding site [nucleotide binding]; other site 508767000396 salt bridge; other site 508767000397 sequence-specific DNA binding site [nucleotide binding]; other site 508767000398 Helix-turn-helix domain; Region: HTH_17; pfam12728 508767000399 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 508767000400 polymerase nucleotide-binding site; other site 508767000401 DNA-binding residues [nucleotide binding]; DNA binding site 508767000402 nucleotide binding site [chemical binding]; other site 508767000403 primase nucleotide-binding site [nucleotide binding]; other site 508767000404 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 508767000405 D5 N terminal like; Region: D5_N; cl07360 508767000406 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 508767000407 Protein of unknown function (DUF3782); Region: DUF3782; pfam12644 508767000408 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 508767000409 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 508767000410 Int/Topo IB signature motif; other site 508767000411 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 508767000412 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 508767000413 putative dimer interface [polypeptide binding]; other site 508767000414 putative anticodon binding site; other site 508767000415 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 508767000416 homodimer interface [polypeptide binding]; other site 508767000417 motif 1; other site 508767000418 motif 2; other site 508767000419 active site 508767000420 motif 3; other site 508767000421 T-box leader 508767000422 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 508767000423 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 508767000424 active site 508767000425 metal binding site [ion binding]; metal-binding site 508767000426 homotetramer interface [polypeptide binding]; other site 508767000427 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 508767000428 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 508767000429 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 508767000430 active site 508767000431 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 508767000432 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 508767000433 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508767000434 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 508767000435 pur operon repressor; Provisional; Region: PRK09213 508767000436 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 508767000437 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508767000438 active site 508767000439 regulatory protein SpoVG; Reviewed; Region: PRK13259 508767000440 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 508767000441 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 508767000442 Substrate binding site; other site 508767000443 Mg++ binding site; other site 508767000444 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 508767000445 active site 508767000446 substrate binding site [chemical binding]; other site 508767000447 CoA binding site [chemical binding]; other site 508767000448 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 508767000449 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 508767000450 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508767000451 active site 508767000452 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767000453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767000454 active site 508767000455 phosphorylation site [posttranslational modification] 508767000456 intermolecular recognition site; other site 508767000457 dimerization interface [polypeptide binding]; other site 508767000458 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767000459 DNA binding site [nucleotide binding] 508767000460 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 508767000461 putative active site [active] 508767000462 catalytic residue [active] 508767000463 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 508767000464 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 508767000465 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508767000466 ATP binding site [chemical binding]; other site 508767000467 putative Mg++ binding site [ion binding]; other site 508767000468 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508767000469 nucleotide binding region [chemical binding]; other site 508767000470 ATP-binding site [chemical binding]; other site 508767000471 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 508767000472 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 508767000473 SurA N-terminal domain; Region: SurA_N_3; cl07813 508767000474 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 508767000475 stage V sporulation protein T; Region: spore_V_T; TIGR02851 508767000476 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 508767000477 stage V sporulation protein B; Region: spore_V_B; TIGR02900 508767000478 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 508767000479 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 508767000480 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 508767000481 putative SAM binding site [chemical binding]; other site 508767000482 putative homodimer interface [polypeptide binding]; other site 508767000483 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 508767000484 homodimer interface [polypeptide binding]; other site 508767000485 metal binding site [ion binding]; metal-binding site 508767000486 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 508767000487 homodimer interface [polypeptide binding]; other site 508767000488 active site 508767000489 putative chemical substrate binding site [chemical binding]; other site 508767000490 metal binding site [ion binding]; metal-binding site 508767000491 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 508767000492 IHF dimer interface [polypeptide binding]; other site 508767000493 IHF - DNA interface [nucleotide binding]; other site 508767000494 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508767000495 RNA binding surface [nucleotide binding]; other site 508767000496 YabP family; Region: YabP; cl06766 508767000497 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 508767000498 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 508767000499 Septum formation initiator; Region: DivIC; pfam04977 508767000500 hypothetical protein; Provisional; Region: PRK05807 508767000501 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 508767000502 RNA binding site [nucleotide binding]; other site 508767000503 stage II sporulation protein E; Region: spore_II_E; TIGR02865 508767000504 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 508767000505 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 508767000506 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 508767000507 Ligand Binding Site [chemical binding]; other site 508767000508 TilS substrate C-terminal domain; Region: TilS_C; smart00977 508767000509 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508767000510 active site 508767000511 FtsH Extracellular; Region: FtsH_ext; pfam06480 508767000512 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 508767000513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767000514 Walker A motif; other site 508767000515 ATP binding site [chemical binding]; other site 508767000516 Walker B motif; other site 508767000517 arginine finger; other site 508767000518 Peptidase family M41; Region: Peptidase_M41; pfam01434 508767000519 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 508767000520 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 508767000521 Potassium binding sites [ion binding]; other site 508767000522 Cesium cation binding sites [ion binding]; other site 508767000523 pantothenate kinase; Reviewed; Region: PRK13318 508767000524 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 508767000525 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 508767000526 FMN binding site [chemical binding]; other site 508767000527 active site 508767000528 catalytic residues [active] 508767000529 substrate binding site [chemical binding]; other site 508767000530 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 508767000531 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 508767000532 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 508767000533 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 508767000534 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 508767000535 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 508767000536 dimer interface [polypeptide binding]; other site 508767000537 putative anticodon binding site; other site 508767000538 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 508767000539 motif 1; other site 508767000540 active site 508767000541 motif 2; other site 508767000542 motif 3; other site 508767000543 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 508767000544 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 508767000545 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 508767000546 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 508767000547 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 508767000548 Cna protein B-type domain; Region: Cna_B; pfam05738 508767000549 T-box leader 508767000550 glycyl-tRNA synthetase; Provisional; Region: PRK04173 508767000551 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 508767000552 motif 1; other site 508767000553 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 508767000554 active site 508767000555 motif 2; other site 508767000556 motif 3; other site 508767000557 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 508767000558 anticodon binding site; other site 508767000559 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 508767000560 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 508767000561 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508767000562 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 508767000563 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 508767000564 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 508767000565 Cl binding site [ion binding]; other site 508767000566 oligomer interface [polypeptide binding]; other site 508767000567 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 508767000568 amidohydrolase; Region: amidohydrolases; TIGR01891 508767000569 metal binding site [ion binding]; metal-binding site 508767000570 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 508767000571 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 508767000572 thymidylate kinase; Provisional; Region: PRK13975; cl17243 508767000573 Protein of unknown function (DUF970); Region: DUF970; pfam06153 508767000574 DNA polymerase III subunit delta'; Validated; Region: PRK05564 508767000575 DNA polymerase III subunit delta'; Validated; Region: PRK08485 508767000576 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 508767000577 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508767000578 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 508767000579 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 508767000580 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 508767000581 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 508767000582 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 508767000583 UvrB/uvrC motif; Region: UVR; pfam02151 508767000584 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 508767000585 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 508767000586 ADP binding site [chemical binding]; other site 508767000587 phosphagen binding site; other site 508767000588 substrate specificity loop; other site 508767000589 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 508767000590 Clp amino terminal domain; Region: Clp_N; pfam02861 508767000591 Clp amino terminal domain; Region: Clp_N; pfam02861 508767000592 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767000593 Walker A motif; other site 508767000594 ATP binding site [chemical binding]; other site 508767000595 Walker B motif; other site 508767000596 arginine finger; other site 508767000597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767000598 Walker A motif; other site 508767000599 ATP binding site [chemical binding]; other site 508767000600 Walker B motif; other site 508767000601 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 508767000602 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 508767000603 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508767000604 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508767000605 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 508767000606 catalytic residues [active] 508767000607 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 508767000608 catalytic residues [active] 508767000609 DNA repair protein RadA; Provisional; Region: PRK11823 508767000610 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 508767000611 Walker A motif/ATP binding site; other site 508767000612 ATP binding site [chemical binding]; other site 508767000613 Walker B motif; other site 508767000614 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 508767000615 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 508767000616 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 508767000617 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 508767000618 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 508767000619 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 508767000620 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 508767000621 putative active site [active] 508767000622 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 508767000623 substrate binding site; other site 508767000624 dimer interface; other site 508767000625 T-box leader 508767000626 prolyl-tRNA synthetase; Provisional; Region: PRK09194 508767000627 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 508767000628 dimer interface [polypeptide binding]; other site 508767000629 motif 1; other site 508767000630 active site 508767000631 motif 2; other site 508767000632 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 508767000633 putative deacylase active site [active] 508767000634 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 508767000635 active site 508767000636 motif 3; other site 508767000637 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 508767000638 anticodon binding site; other site 508767000639 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 508767000640 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 508767000641 active site 508767000642 HIGH motif; other site 508767000643 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 508767000644 KMSKS motif; other site 508767000645 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 508767000646 tRNA binding surface [nucleotide binding]; other site 508767000647 anticodon binding site; other site 508767000648 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 508767000649 dimerization interface [polypeptide binding]; other site 508767000650 active site 508767000651 metal binding site [ion binding]; metal-binding site 508767000652 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 508767000653 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 508767000654 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 508767000655 YacP-like NYN domain; Region: NYN_YacP; pfam05991 508767000656 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 508767000657 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508767000658 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 508767000659 elongation factor Tu; Reviewed; Region: PRK00049 508767000660 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 508767000661 G1 box; other site 508767000662 GEF interaction site [polypeptide binding]; other site 508767000663 GTP/Mg2+ binding site [chemical binding]; other site 508767000664 Switch I region; other site 508767000665 G2 box; other site 508767000666 G3 box; other site 508767000667 Switch II region; other site 508767000668 G4 box; other site 508767000669 G5 box; other site 508767000670 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 508767000671 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 508767000672 Antibiotic Binding Site [chemical binding]; other site 508767000673 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 508767000674 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 508767000675 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 508767000676 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 508767000677 putative homodimer interface [polypeptide binding]; other site 508767000678 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 508767000679 heterodimer interface [polypeptide binding]; other site 508767000680 homodimer interface [polypeptide binding]; other site 508767000681 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 508767000682 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 508767000683 23S rRNA interface [nucleotide binding]; other site 508767000684 L7/L12 interface [polypeptide binding]; other site 508767000685 putative thiostrepton binding site; other site 508767000686 L25 interface [polypeptide binding]; other site 508767000687 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 508767000688 mRNA/rRNA interface [nucleotide binding]; other site 508767000689 Ribosomal protein L10 leader 508767000690 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 508767000691 23S rRNA interface [nucleotide binding]; other site 508767000692 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 508767000693 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 508767000694 core dimer interface [polypeptide binding]; other site 508767000695 peripheral dimer interface [polypeptide binding]; other site 508767000696 L10 interface [polypeptide binding]; other site 508767000697 L11 interface [polypeptide binding]; other site 508767000698 putative EF-Tu interaction site [polypeptide binding]; other site 508767000699 putative EF-G interaction site [polypeptide binding]; other site 508767000700 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 508767000701 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 508767000702 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 508767000703 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 508767000704 RPB1 interaction site [polypeptide binding]; other site 508767000705 RPB10 interaction site [polypeptide binding]; other site 508767000706 RPB11 interaction site [polypeptide binding]; other site 508767000707 RPB3 interaction site [polypeptide binding]; other site 508767000708 RPB12 interaction site [polypeptide binding]; other site 508767000709 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 508767000710 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 508767000711 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 508767000712 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 508767000713 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 508767000714 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 508767000715 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 508767000716 G-loop; other site 508767000717 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 508767000718 DNA binding site [nucleotide binding] 508767000719 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 508767000720 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 508767000721 S17 interaction site [polypeptide binding]; other site 508767000722 S8 interaction site; other site 508767000723 16S rRNA interaction site [nucleotide binding]; other site 508767000724 streptomycin interaction site [chemical binding]; other site 508767000725 23S rRNA interaction site [nucleotide binding]; other site 508767000726 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 508767000727 30S ribosomal protein S7; Validated; Region: PRK05302 508767000728 elongation factor G; Reviewed; Region: PRK00007 508767000729 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 508767000730 G1 box; other site 508767000731 putative GEF interaction site [polypeptide binding]; other site 508767000732 GTP/Mg2+ binding site [chemical binding]; other site 508767000733 Switch I region; other site 508767000734 G2 box; other site 508767000735 G3 box; other site 508767000736 Switch II region; other site 508767000737 G4 box; other site 508767000738 G5 box; other site 508767000739 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 508767000740 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 508767000741 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 508767000742 elongation factor Tu; Reviewed; Region: PRK00049 508767000743 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 508767000744 G1 box; other site 508767000745 GEF interaction site [polypeptide binding]; other site 508767000746 GTP/Mg2+ binding site [chemical binding]; other site 508767000747 Switch I region; other site 508767000748 G2 box; other site 508767000749 G3 box; other site 508767000750 Switch II region; other site 508767000751 G4 box; other site 508767000752 G5 box; other site 508767000753 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 508767000754 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 508767000755 Antibiotic Binding Site [chemical binding]; other site 508767000756 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 508767000757 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 508767000758 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 508767000759 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 508767000760 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 508767000761 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 508767000762 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 508767000763 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 508767000764 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 508767000765 putative translocon binding site; other site 508767000766 protein-rRNA interface [nucleotide binding]; other site 508767000767 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 508767000768 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 508767000769 G-X-X-G motif; other site 508767000770 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 508767000771 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 508767000772 23S rRNA interface [nucleotide binding]; other site 508767000773 5S rRNA interface [nucleotide binding]; other site 508767000774 putative antibiotic binding site [chemical binding]; other site 508767000775 L25 interface [polypeptide binding]; other site 508767000776 L27 interface [polypeptide binding]; other site 508767000777 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 508767000778 23S rRNA interface [nucleotide binding]; other site 508767000779 putative translocon interaction site; other site 508767000780 signal recognition particle (SRP54) interaction site; other site 508767000781 L23 interface [polypeptide binding]; other site 508767000782 trigger factor interaction site; other site 508767000783 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 508767000784 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 508767000785 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 508767000786 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 508767000787 RNA binding site [nucleotide binding]; other site 508767000788 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 508767000789 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 508767000790 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 508767000791 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 508767000792 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 508767000793 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 508767000794 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 508767000795 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 508767000796 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 508767000797 5S rRNA interface [nucleotide binding]; other site 508767000798 L27 interface [polypeptide binding]; other site 508767000799 23S rRNA interface [nucleotide binding]; other site 508767000800 L5 interface [polypeptide binding]; other site 508767000801 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 508767000802 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 508767000803 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 508767000804 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 508767000805 23S rRNA binding site [nucleotide binding]; other site 508767000806 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 508767000807 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 508767000808 SecY translocase; Region: SecY; pfam00344 508767000809 adenylate kinase; Reviewed; Region: adk; PRK00279 508767000810 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 508767000811 AMP-binding site [chemical binding]; other site 508767000812 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 508767000813 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 508767000814 active site 508767000815 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 508767000816 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 508767000817 rRNA binding site [nucleotide binding]; other site 508767000818 predicted 30S ribosome binding site; other site 508767000819 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 508767000820 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 508767000821 30S ribosomal protein S13; Region: bact_S13; TIGR03631 508767000822 30S ribosomal protein S11; Validated; Region: PRK05309 508767000823 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 508767000824 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 508767000825 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508767000826 RNA binding surface [nucleotide binding]; other site 508767000827 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 508767000828 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 508767000829 alphaNTD homodimer interface [polypeptide binding]; other site 508767000830 alphaNTD - beta interaction site [polypeptide binding]; other site 508767000831 alphaNTD - beta' interaction site [polypeptide binding]; other site 508767000832 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 508767000833 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 508767000834 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 508767000835 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 508767000836 Walker A/P-loop; other site 508767000837 ATP binding site [chemical binding]; other site 508767000838 Q-loop/lid; other site 508767000839 ABC transporter signature motif; other site 508767000840 Walker B; other site 508767000841 D-loop; other site 508767000842 H-loop/switch region; other site 508767000843 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 508767000844 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 508767000845 Walker A/P-loop; other site 508767000846 ATP binding site [chemical binding]; other site 508767000847 Q-loop/lid; other site 508767000848 ABC transporter signature motif; other site 508767000849 Walker B; other site 508767000850 D-loop; other site 508767000851 H-loop/switch region; other site 508767000852 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 508767000853 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 508767000854 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 508767000855 dimerization interface 3.5A [polypeptide binding]; other site 508767000856 active site 508767000857 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 508767000858 23S rRNA interface [nucleotide binding]; other site 508767000859 L3 interface [polypeptide binding]; other site 508767000860 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 508767000861 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 508767000862 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 508767000863 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 508767000864 PhoU domain; Region: PhoU; pfam01895 508767000865 PhoU domain; Region: PhoU; pfam01895 508767000866 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 508767000867 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 508767000868 active site 508767000869 metal binding site [ion binding]; metal-binding site 508767000870 fumarate hydratase; Provisional; Region: PRK06246 508767000871 fumarate hydratase; Provisional; Region: PRK06842 508767000872 Uncharacterized conserved protein [Function unknown]; Region: COG1284 508767000873 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508767000874 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508767000875 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 508767000876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508767000877 TPR motif; other site 508767000878 binding surface 508767000879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508767000880 binding surface 508767000881 TPR motif; other site 508767000882 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767000883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767000884 active site 508767000885 phosphorylation site [posttranslational modification] 508767000886 intermolecular recognition site; other site 508767000887 dimerization interface [polypeptide binding]; other site 508767000888 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767000889 DNA binding site [nucleotide binding] 508767000890 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767000891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767000892 dimer interface [polypeptide binding]; other site 508767000893 phosphorylation site [posttranslational modification] 508767000894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767000895 ATP binding site [chemical binding]; other site 508767000896 Mg2+ binding site [ion binding]; other site 508767000897 G-X-G motif; other site 508767000898 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088 508767000899 Class I ribonucleotide reductase; Region: RNR_I; cd01679 508767000900 active site 508767000901 dimer interface [polypeptide binding]; other site 508767000902 catalytic residues [active] 508767000903 effector binding site; other site 508767000904 R2 peptide binding site; other site 508767000905 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 508767000906 dimer interface [polypeptide binding]; other site 508767000907 putative radical transfer pathway; other site 508767000908 diiron center [ion binding]; other site 508767000909 tyrosyl radical; other site 508767000910 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 508767000911 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 508767000912 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 508767000913 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 508767000914 Chromate transporter; Region: Chromate_transp; pfam02417 508767000915 Chromate transporter; Region: Chromate_transp; pfam02417 508767000916 Tetratricopeptide repeat; Region: TPR_16; pfam13432 508767000917 isoaspartyl dipeptidase; Provisional; Region: PRK10657 508767000918 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 508767000919 active site 508767000920 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 508767000921 Uncharacterized conserved protein [Function unknown]; Region: COG1624 508767000922 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 508767000923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 508767000924 YbbR-like protein; Region: YbbR; pfam07949 508767000925 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 508767000926 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508767000927 phosphate butyryltransferase; Validated; Region: PRK05805 508767000928 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 508767000929 nucleotide binding site [chemical binding]; other site 508767000930 Acetokinase family; Region: Acetate_kinase; cl17229 508767000931 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 508767000932 Trp repressor protein; Region: Trp_repressor; cl17266 508767000933 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 508767000934 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 508767000935 active site 508767000936 substrate binding site [chemical binding]; other site 508767000937 metal binding site [ion binding]; metal-binding site 508767000938 T-box leader 508767000939 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 508767000940 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 508767000941 putative valine binding site [chemical binding]; other site 508767000942 dimer interface [polypeptide binding]; other site 508767000943 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 508767000944 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 508767000945 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 508767000946 substrate binding site [chemical binding]; other site 508767000947 ligand binding site [chemical binding]; other site 508767000948 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 508767000949 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 508767000950 substrate binding site [chemical binding]; other site 508767000951 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 508767000952 tartrate dehydrogenase; Provisional; Region: PRK08194 508767000953 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 508767000954 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 508767000955 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 508767000956 PYR/PP interface [polypeptide binding]; other site 508767000957 dimer interface [polypeptide binding]; other site 508767000958 TPP binding site [chemical binding]; other site 508767000959 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 508767000960 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 508767000961 TPP-binding site [chemical binding]; other site 508767000962 dimer interface [polypeptide binding]; other site 508767000963 ketol-acid reductoisomerase; Provisional; Region: PRK05479 508767000964 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 508767000965 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 508767000966 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 508767000967 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 508767000968 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 508767000969 Walker A/P-loop; other site 508767000970 ATP binding site [chemical binding]; other site 508767000971 Q-loop/lid; other site 508767000972 ABC transporter signature motif; other site 508767000973 Walker B; other site 508767000974 D-loop; other site 508767000975 H-loop/switch region; other site 508767000976 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 508767000977 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 508767000978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767000979 Walker A/P-loop; other site 508767000980 ATP binding site [chemical binding]; other site 508767000981 Q-loop/lid; other site 508767000982 ABC transporter signature motif; other site 508767000983 Walker B; other site 508767000984 D-loop; other site 508767000985 H-loop/switch region; other site 508767000986 MarR family; Region: MarR_2; pfam12802 508767000987 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 508767000988 GIY-YIG motif/motif A; other site 508767000989 putative active site [active] 508767000990 putative metal binding site [ion binding]; other site 508767000991 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508767000992 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508767000993 DNA binding site [nucleotide binding] 508767000994 domain linker motif; other site 508767000995 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 508767000996 putative dimerization interface [polypeptide binding]; other site 508767000997 putative ligand binding site [chemical binding]; other site 508767000998 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 508767000999 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 508767001000 Ca binding site [ion binding]; other site 508767001001 active site 508767001002 catalytic site [active] 508767001003 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 508767001004 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 508767001005 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508767001006 active site turn [active] 508767001007 phosphorylation site [posttranslational modification] 508767001008 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 508767001009 putative catalytic site [active] 508767001010 putative metal binding site [ion binding]; other site 508767001011 putative phosphate binding site [ion binding]; other site 508767001012 Transcriptional regulators [Transcription]; Region: MarR; COG1846 508767001013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508767001014 dimerization interface [polypeptide binding]; other site 508767001015 putative Zn2+ binding site [ion binding]; other site 508767001016 putative DNA binding site [nucleotide binding]; other site 508767001017 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 508767001018 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 508767001019 HlyD family secretion protein; Region: HlyD_3; pfam13437 508767001020 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 508767001021 Protein export membrane protein; Region: SecD_SecF; cl14618 508767001022 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 508767001023 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 508767001024 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 508767001025 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 508767001026 glutaminase active site [active] 508767001027 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 508767001028 dimer interface [polypeptide binding]; other site 508767001029 active site 508767001030 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 508767001031 dimer interface [polypeptide binding]; other site 508767001032 active site 508767001033 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 508767001034 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508767001035 ligand binding site [chemical binding]; other site 508767001036 flexible hinge region; other site 508767001037 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 508767001038 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508767001039 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 508767001040 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 508767001041 active site 508767001042 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 508767001043 substrate binding site [chemical binding]; other site 508767001044 metal binding site [ion binding]; metal-binding site 508767001045 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 508767001046 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 508767001047 TrkA-C domain; Region: TrkA_C; pfam02080 508767001048 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 508767001049 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 508767001050 active site clefts [active] 508767001051 zinc binding site [ion binding]; other site 508767001052 dimer interface [polypeptide binding]; other site 508767001053 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 508767001054 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 508767001055 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 508767001056 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 508767001057 homodimer interface [polypeptide binding]; other site 508767001058 substrate-cofactor binding pocket; other site 508767001059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767001060 catalytic residue [active] 508767001061 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 508767001062 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 508767001063 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 508767001064 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 508767001065 active site 508767001066 dimer interface [polypeptide binding]; other site 508767001067 motif 1; other site 508767001068 motif 2; other site 508767001069 motif 3; other site 508767001070 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 508767001071 anticodon binding site; other site 508767001072 T-box leader 508767001073 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 508767001074 active site 508767001075 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 508767001076 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 508767001077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508767001078 putative substrate translocation pore; other site 508767001079 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 508767001080 homotrimer interaction site [polypeptide binding]; other site 508767001081 zinc binding site [ion binding]; other site 508767001082 CDP-binding sites; other site 508767001083 Pleckstrin homology-like domain; Region: PH-like; cl17171 508767001084 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 508767001085 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 508767001086 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 508767001087 putative active site [active] 508767001088 putative metal binding site [ion binding]; other site 508767001089 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 508767001090 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 508767001091 Uncharacterized conserved protein [Function unknown]; Region: COG1284 508767001092 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508767001093 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508767001094 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 508767001095 biotin synthase; Provisional; Region: PRK07094 508767001096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767001097 FeS/SAM binding site; other site 508767001098 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 508767001099 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 508767001100 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 508767001101 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508767001102 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 508767001103 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 508767001104 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 508767001105 Transcriptional regulators [Transcription]; Region: FadR; COG2186 508767001106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508767001107 DNA-binding site [nucleotide binding]; DNA binding site 508767001108 FCD domain; Region: FCD; pfam07729 508767001109 L-lactate permease; Region: Lactate_perm; cl00701 508767001110 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 508767001111 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 508767001112 Ligand binding site [chemical binding]; other site 508767001113 Electron transfer flavoprotein domain; Region: ETF; pfam01012 508767001114 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 508767001115 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 508767001116 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 508767001117 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 508767001118 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 508767001119 FAD binding domain; Region: FAD_binding_4; pfam01565 508767001120 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 508767001121 L-lactate permease; Region: Lactate_perm; cl00701 508767001122 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 508767001123 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 508767001124 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 508767001125 active site 508767001126 nucleophile elbow; other site 508767001127 transcription termination factor Rho; Provisional; Region: rho; PRK09376 508767001128 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 508767001129 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 508767001130 Substrate binding site; other site 508767001131 Cupin domain; Region: Cupin_2; cl17218 508767001132 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 508767001133 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508767001134 dimerization interface [polypeptide binding]; other site 508767001135 putative DNA binding site [nucleotide binding]; other site 508767001136 putative Zn2+ binding site [ion binding]; other site 508767001137 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 508767001138 metal-binding site [ion binding] 508767001139 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 508767001140 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508767001141 Soluble P-type ATPase [General function prediction only]; Region: COG4087 508767001142 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 508767001143 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 508767001144 CoA binding domain; Region: CoA_binding; pfam02629 508767001145 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 508767001146 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 508767001147 substrate binding site [chemical binding]; other site 508767001148 oxyanion hole (OAH) forming residues; other site 508767001149 trimer interface [polypeptide binding]; other site 508767001150 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 508767001151 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 508767001152 FAD binding site [chemical binding]; other site 508767001153 homotetramer interface [polypeptide binding]; other site 508767001154 substrate binding pocket [chemical binding]; other site 508767001155 catalytic base [active] 508767001156 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 508767001157 Ligand binding site [chemical binding]; other site 508767001158 Electron transfer flavoprotein domain; Region: ETF; pfam01012 508767001159 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 508767001160 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 508767001161 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 508767001162 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 508767001163 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 508767001164 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 508767001165 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 508767001166 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 508767001167 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 508767001168 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 508767001169 minor groove reading motif; other site 508767001170 helix-hairpin-helix signature motif; other site 508767001171 substrate binding pocket [chemical binding]; other site 508767001172 active site 508767001173 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 508767001174 4Fe-4S binding domain; Region: Fer4; pfam00037 508767001175 4Fe-4S binding domain; Region: Fer4; pfam00037 508767001176 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 508767001177 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767001178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767001179 active site 508767001180 phosphorylation site [posttranslational modification] 508767001181 intermolecular recognition site; other site 508767001182 dimerization interface [polypeptide binding]; other site 508767001183 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767001184 DNA binding site [nucleotide binding] 508767001185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767001186 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767001187 dimerization interface [polypeptide binding]; other site 508767001188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767001189 dimer interface [polypeptide binding]; other site 508767001190 phosphorylation site [posttranslational modification] 508767001191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767001192 ATP binding site [chemical binding]; other site 508767001193 Mg2+ binding site [ion binding]; other site 508767001194 G-X-G motif; other site 508767001195 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 508767001196 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 508767001197 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 508767001198 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 508767001199 oligomerisation interface [polypeptide binding]; other site 508767001200 mobile loop; other site 508767001201 roof hairpin; other site 508767001202 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 508767001203 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 508767001204 ring oligomerisation interface [polypeptide binding]; other site 508767001205 ATP/Mg binding site [chemical binding]; other site 508767001206 stacking interactions; other site 508767001207 hinge regions; other site 508767001208 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 508767001209 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 508767001210 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 508767001211 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 508767001212 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 508767001213 active site 508767001214 GMP synthase; Reviewed; Region: guaA; PRK00074 508767001215 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 508767001216 AMP/PPi binding site [chemical binding]; other site 508767001217 candidate oxyanion hole; other site 508767001218 catalytic triad [active] 508767001219 potential glutamine specificity residues [chemical binding]; other site 508767001220 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 508767001221 ATP Binding subdomain [chemical binding]; other site 508767001222 Ligand Binding sites [chemical binding]; other site 508767001223 Dimerization subdomain; other site 508767001224 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 508767001225 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 508767001226 putative active site [active] 508767001227 putative metal binding site [ion binding]; other site 508767001228 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 508767001229 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 508767001230 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 508767001231 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 508767001232 HTH domain; Region: HTH_11; pfam08279 508767001233 PRD domain; Region: PRD; pfam00874 508767001234 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 508767001235 active site 508767001236 P-loop; other site 508767001237 phosphorylation site [posttranslational modification] 508767001238 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 508767001239 active site 508767001240 phosphorylation site [posttranslational modification] 508767001241 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 508767001242 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 508767001243 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 508767001244 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 508767001245 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 508767001246 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 508767001247 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 508767001248 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 508767001249 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 508767001250 classical (c) SDRs; Region: SDR_c; cd05233 508767001251 NAD(P) binding site [chemical binding]; other site 508767001252 active site 508767001253 Class I aldolases; Region: Aldolase_Class_I; cl17187 508767001254 catalytic residue [active] 508767001255 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 508767001256 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 508767001257 active site 508767001258 dimer interface [polypeptide binding]; other site 508767001259 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 508767001260 dimer interface [polypeptide binding]; other site 508767001261 active site 508767001262 hypothetical protein; Validated; Region: PRK00124 508767001263 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 508767001264 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 508767001265 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 508767001266 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 508767001267 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 508767001268 N-acetyl-D-glucosamine binding site [chemical binding]; other site 508767001269 catalytic residue [active] 508767001270 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 508767001271 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508767001272 RNA binding surface [nucleotide binding]; other site 508767001273 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 508767001274 active site 508767001275 uracil binding [chemical binding]; other site 508767001276 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 508767001277 Part of AAA domain; Region: AAA_19; pfam13245 508767001278 Family description; Region: UvrD_C_2; pfam13538 508767001279 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 508767001280 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 508767001281 nucleotide binding pocket [chemical binding]; other site 508767001282 K-X-D-G motif; other site 508767001283 catalytic site [active] 508767001284 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 508767001285 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 508767001286 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 508767001287 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 508767001288 Dimer interface [polypeptide binding]; other site 508767001289 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 508767001290 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 508767001291 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 508767001292 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 508767001293 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 508767001294 GatB domain; Region: GatB_Yqey; smart00845 508767001295 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 508767001296 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 508767001297 ribonuclease PH; Reviewed; Region: rph; PRK00173 508767001298 Ribonuclease PH; Region: RNase_PH_bact; cd11362 508767001299 hexamer interface [polypeptide binding]; other site 508767001300 active site 508767001301 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 508767001302 active site 508767001303 dimerization interface [polypeptide binding]; other site 508767001304 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 508767001305 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 508767001306 active site 508767001307 metal binding site [ion binding]; metal-binding site 508767001308 homotetramer interface [polypeptide binding]; other site 508767001309 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 508767001310 Zn binding site [ion binding]; other site 508767001311 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 508767001312 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 508767001313 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 508767001314 NodB motif; other site 508767001315 active site 508767001316 catalytic site [active] 508767001317 Zn binding site [ion binding]; other site 508767001318 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767001319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767001320 active site 508767001321 phosphorylation site [posttranslational modification] 508767001322 intermolecular recognition site; other site 508767001323 dimerization interface [polypeptide binding]; other site 508767001324 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767001325 DNA binding site [nucleotide binding] 508767001326 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767001327 dimerization interface [polypeptide binding]; other site 508767001328 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767001329 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767001330 dimer interface [polypeptide binding]; other site 508767001331 phosphorylation site [posttranslational modification] 508767001332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767001333 ATP binding site [chemical binding]; other site 508767001334 Mg2+ binding site [ion binding]; other site 508767001335 G-X-G motif; other site 508767001336 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 508767001337 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 508767001338 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 508767001339 Sulfatase; Region: Sulfatase; cl17466 508767001340 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 508767001341 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 508767001342 CPxP motif; other site 508767001343 DsrE/DsrF-like family; Region: DrsE; cl00672 508767001344 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 508767001345 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508767001346 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 508767001347 active site 508767001348 catalytic triad [active] 508767001349 oxyanion hole [active] 508767001350 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 508767001351 UGMP family protein; Validated; Region: PRK09604 508767001352 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 508767001353 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 508767001354 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 508767001355 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 508767001356 active site 508767001357 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 508767001358 protein binding site [polypeptide binding]; other site 508767001359 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 508767001360 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 508767001361 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 508767001362 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 508767001363 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 508767001364 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 508767001365 spore coat protein YutH; Region: spore_yutH; TIGR02905 508767001366 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 508767001367 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 508767001368 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 508767001369 substrate binding site [chemical binding]; other site 508767001370 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 508767001371 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 508767001372 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 508767001373 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 508767001374 active site 508767001375 ATP binding site [chemical binding]; other site 508767001376 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 508767001377 substrate binding site [chemical binding]; other site 508767001378 YabG peptidase U57; Region: Peptidase_U57; pfam05582 508767001379 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 508767001380 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 508767001381 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 508767001382 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 508767001383 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 508767001384 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 508767001385 proposed catalytic triad [active] 508767001386 active site nucleophile [active] 508767001387 cyanophycin synthetase; Provisional; Region: PRK14016 508767001388 ATP-grasp domain; Region: ATP-grasp_4; cl17255 508767001389 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508767001390 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 508767001391 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 508767001392 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 508767001393 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 508767001394 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 508767001395 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 508767001396 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 508767001397 Ligand Binding Site [chemical binding]; other site 508767001398 Domain of unknown function (DUF814); Region: DUF814; pfam05670 508767001399 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 508767001400 CTP synthetase; Validated; Region: pyrG; PRK05380 508767001401 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 508767001402 Catalytic site [active] 508767001403 active site 508767001404 UTP binding site [chemical binding]; other site 508767001405 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 508767001406 active site 508767001407 putative oxyanion hole; other site 508767001408 catalytic triad [active] 508767001409 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 508767001410 transcription termination factor Rho; Provisional; Region: PRK12608 508767001411 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 508767001412 RNA binding site [nucleotide binding]; other site 508767001413 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 508767001414 multimer interface [polypeptide binding]; other site 508767001415 Walker A motif; other site 508767001416 ATP binding site [chemical binding]; other site 508767001417 Walker B motif; other site 508767001418 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 508767001419 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 508767001420 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 508767001421 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 508767001422 thymidine kinase; Provisional; Region: PRK04296 508767001423 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 508767001424 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 508767001425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767001426 S-adenosylmethionine binding site [chemical binding]; other site 508767001427 peptide chain release factor 1; Validated; Region: prfA; PRK00591 508767001428 This domain is found in peptide chain release factors; Region: PCRF; smart00937 508767001429 RF-1 domain; Region: RF-1; pfam00472 508767001430 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 508767001431 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 508767001432 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 508767001433 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508767001434 active site 508767001435 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 508767001436 active site 508767001437 Zn binding site [ion binding]; other site 508767001438 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 508767001439 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 508767001440 active site 508767001441 homodimer interface [polypeptide binding]; other site 508767001442 putative acyltransferase; Provisional; Region: PRK05790 508767001443 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 508767001444 dimer interface [polypeptide binding]; other site 508767001445 active site 508767001446 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 508767001447 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 508767001448 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 508767001449 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 508767001450 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 508767001451 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 508767001452 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 508767001453 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 508767001454 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 508767001455 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 508767001456 beta subunit interaction interface [polypeptide binding]; other site 508767001457 Walker A motif; other site 508767001458 ATP binding site [chemical binding]; other site 508767001459 Walker B motif; other site 508767001460 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 508767001461 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 508767001462 core domain interface [polypeptide binding]; other site 508767001463 delta subunit interface [polypeptide binding]; other site 508767001464 epsilon subunit interface [polypeptide binding]; other site 508767001465 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 508767001466 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 508767001467 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 508767001468 alpha subunit interaction interface [polypeptide binding]; other site 508767001469 Walker A motif; other site 508767001470 ATP binding site [chemical binding]; other site 508767001471 Walker B motif; other site 508767001472 inhibitor binding site; inhibition site 508767001473 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 508767001474 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450 508767001475 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 508767001476 gamma subunit interface [polypeptide binding]; other site 508767001477 epsilon subunit interface [polypeptide binding]; other site 508767001478 LBP interface [polypeptide binding]; other site 508767001479 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 508767001480 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 508767001481 hinge; other site 508767001482 active site 508767001483 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 508767001484 Stage II sporulation protein; Region: SpoIID; pfam08486 508767001485 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 508767001486 Peptidase family M23; Region: Peptidase_M23; pfam01551 508767001487 Stage III sporulation protein D; Region: SpoIIID; pfam12116 508767001488 rod shape-determining protein Mbl; Provisional; Region: PRK13928 508767001489 MreB and similar proteins; Region: MreB_like; cd10225 508767001490 nucleotide binding site [chemical binding]; other site 508767001491 Mg binding site [ion binding]; other site 508767001492 putative protofilament interaction site [polypeptide binding]; other site 508767001493 RodZ interaction site [polypeptide binding]; other site 508767001494 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 508767001495 S-adenosylmethionine synthetase; Validated; Region: PRK05250 508767001496 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 508767001497 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 508767001498 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 508767001499 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 508767001500 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 508767001501 DNA binding site [nucleotide binding] 508767001502 AAA domain; Region: AAA_30; pfam13604 508767001503 Family description; Region: UvrD_C_2; pfam13538 508767001504 comF family protein; Region: comF; TIGR00201 508767001505 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508767001506 active site 508767001507 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 508767001508 30S subunit binding site; other site 508767001509 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 508767001510 DEAD/DEAH box helicase; Region: DEAD; pfam00270 508767001511 ATP binding site [chemical binding]; other site 508767001512 putative Mg++ binding site [ion binding]; other site 508767001513 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 508767001514 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 508767001515 nucleotide binding region [chemical binding]; other site 508767001516 ATP-binding site [chemical binding]; other site 508767001517 SEC-C motif; Region: SEC-C; pfam02810 508767001518 peptide chain release factor 2; Provisional; Region: PRK05589 508767001519 This domain is found in peptide chain release factors; Region: PCRF; smart00937 508767001520 RF-1 domain; Region: RF-1; pfam00472 508767001521 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 508767001522 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 508767001523 Peptidase family M28; Region: Peptidase_M28; pfam04389 508767001524 metal binding site [ion binding]; metal-binding site 508767001525 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 508767001526 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 508767001527 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 508767001528 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 508767001529 RNA binding site [nucleotide binding]; other site 508767001530 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 508767001531 EamA-like transporter family; Region: EamA; pfam00892 508767001532 EamA-like transporter family; Region: EamA; pfam00892 508767001533 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 508767001534 Predicted membrane protein [Function unknown]; Region: COG3601 508767001535 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 508767001536 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 508767001537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767001538 Coenzyme A binding pocket [chemical binding]; other site 508767001539 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 508767001540 Glycoprotease family; Region: Peptidase_M22; pfam00814 508767001541 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 508767001542 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 508767001543 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 508767001544 intersubunit interface [polypeptide binding]; other site 508767001545 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 508767001546 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 508767001547 FMN binding site [chemical binding]; other site 508767001548 substrate binding site [chemical binding]; other site 508767001549 putative catalytic residue [active] 508767001550 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 508767001551 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 508767001552 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 508767001553 active site 508767001554 metal binding site [ion binding]; metal-binding site 508767001555 DNA binding site [nucleotide binding] 508767001556 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 508767001557 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 508767001558 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 508767001559 intersubunit interface [polypeptide binding]; other site 508767001560 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 508767001561 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 508767001562 Walker A/P-loop; other site 508767001563 ATP binding site [chemical binding]; other site 508767001564 Q-loop/lid; other site 508767001565 ABC transporter signature motif; other site 508767001566 Walker B; other site 508767001567 D-loop; other site 508767001568 H-loop/switch region; other site 508767001569 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 508767001570 active site 508767001571 catalytic site [active] 508767001572 substrate binding site [chemical binding]; other site 508767001573 FOG: CBS domain [General function prediction only]; Region: COG0517 508767001574 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 508767001575 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 508767001576 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 508767001577 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 508767001578 RNA binding site [nucleotide binding]; other site 508767001579 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 508767001580 RNA binding site [nucleotide binding]; other site 508767001581 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 508767001582 RNA binding site [nucleotide binding]; other site 508767001583 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 508767001584 RNA binding site [nucleotide binding]; other site 508767001585 domain interface; other site 508767001586 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 508767001587 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 508767001588 domain interfaces; other site 508767001589 active site 508767001590 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 508767001591 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 508767001592 metal binding site [ion binding]; metal-binding site 508767001593 dimer interface [polypeptide binding]; other site 508767001594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767001595 Coenzyme A binding pocket [chemical binding]; other site 508767001596 Sporulation related domain; Region: SPOR; pfam05036 508767001597 Maf-like protein; Reviewed; Region: PRK00078 508767001598 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 508767001599 active site 508767001600 dimer interface [polypeptide binding]; other site 508767001601 hypothetical protein; Reviewed; Region: PRK00024 508767001602 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 508767001603 MPN+ (JAMM) motif; other site 508767001604 Zinc-binding site [ion binding]; other site 508767001605 rod shape-determining protein MreB; Provisional; Region: PRK13927 508767001606 MreB and similar proteins; Region: MreB_like; cd10225 508767001607 nucleotide binding site [chemical binding]; other site 508767001608 Mg binding site [ion binding]; other site 508767001609 putative protofilament interaction site [polypeptide binding]; other site 508767001610 RodZ interaction site [polypeptide binding]; other site 508767001611 rod shape-determining protein MreC; Provisional; Region: PRK13922 508767001612 rod shape-determining protein MreC; Region: MreC; pfam04085 508767001613 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 508767001614 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 508767001615 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 508767001616 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 508767001617 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 508767001618 septum formation inhibitor; Reviewed; Region: minC; PRK00513 508767001619 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 508767001620 septum site-determining protein MinD; Region: minD_bact; TIGR01968 508767001621 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 508767001622 Switch I; other site 508767001623 Switch II; other site 508767001624 cell division topological specificity factor MinE; Provisional; Region: PRK13987 508767001625 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 508767001626 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 508767001627 active site 508767001628 dimer interfaces [polypeptide binding]; other site 508767001629 catalytic residues [active] 508767001630 Peptidase family M23; Region: Peptidase_M23; pfam01551 508767001631 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 508767001632 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 508767001633 Peptidase family M50; Region: Peptidase_M50; pfam02163 508767001634 active site 508767001635 putative substrate binding region [chemical binding]; other site 508767001636 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 508767001637 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767001638 FeS/SAM binding site; other site 508767001639 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 508767001640 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 508767001641 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 508767001642 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 508767001643 homodimer interface [polypeptide binding]; other site 508767001644 oligonucleotide binding site [chemical binding]; other site 508767001645 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 508767001646 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 508767001647 hypothetical protein; Provisional; Region: PRK14553 508767001648 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 508767001649 GTPase CgtA; Reviewed; Region: obgE; PRK12297 508767001650 GTP1/OBG; Region: GTP1_OBG; pfam01018 508767001651 Obg GTPase; Region: Obg; cd01898 508767001652 G1 box; other site 508767001653 GTP/Mg2+ binding site [chemical binding]; other site 508767001654 Switch I region; other site 508767001655 G2 box; other site 508767001656 G3 box; other site 508767001657 Switch II region; other site 508767001658 G4 box; other site 508767001659 G5 box; other site 508767001660 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 508767001661 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 508767001662 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 508767001663 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 508767001664 active site 508767001665 (T/H)XGH motif; other site 508767001666 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508767001667 Zn2+ binding site [ion binding]; other site 508767001668 Mg2+ binding site [ion binding]; other site 508767001669 Transcriptional regulator [Transcription]; Region: LytR; COG1316 508767001670 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 508767001671 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 508767001672 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 508767001673 RNA binding surface [nucleotide binding]; other site 508767001674 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 508767001675 active site 508767001676 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 508767001677 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 508767001678 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 508767001679 SLBB domain; Region: SLBB; pfam10531 508767001680 comEA protein; Region: comE; TIGR01259 508767001681 TRAM domain; Region: TRAM; cl01282 508767001682 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 508767001683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767001684 S-adenosylmethionine binding site [chemical binding]; other site 508767001685 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 508767001686 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 508767001687 intersubunit interface [polypeptide binding]; other site 508767001688 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 508767001689 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508767001690 ABC-ATPase subunit interface; other site 508767001691 dimer interface [polypeptide binding]; other site 508767001692 putative PBP binding regions; other site 508767001693 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 508767001694 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 508767001695 Walker A/P-loop; other site 508767001696 ATP binding site [chemical binding]; other site 508767001697 Q-loop/lid; other site 508767001698 ABC transporter signature motif; other site 508767001699 Walker B; other site 508767001700 D-loop; other site 508767001701 H-loop/switch region; other site 508767001702 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 508767001703 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 508767001704 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 508767001705 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 508767001706 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508767001707 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508767001708 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508767001709 metal binding site [ion binding]; metal-binding site 508767001710 active site 508767001711 I-site; other site 508767001712 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 508767001713 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 508767001714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767001715 Walker A motif; other site 508767001716 ATP binding site [chemical binding]; other site 508767001717 Walker B motif; other site 508767001718 arginine finger; other site 508767001719 peptidase; Reviewed; Region: PRK13004 508767001720 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 508767001721 putative metal binding site [ion binding]; other site 508767001722 putative dimer interface [polypeptide binding]; other site 508767001723 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 508767001724 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 508767001725 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 508767001726 carbamate kinase; Reviewed; Region: PRK12686 508767001727 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 508767001728 putative substrate binding site [chemical binding]; other site 508767001729 nucleotide binding site [chemical binding]; other site 508767001730 nucleotide binding site [chemical binding]; other site 508767001731 homodimer interface [polypeptide binding]; other site 508767001732 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 508767001733 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 508767001734 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508767001735 catalytic residue [active] 508767001736 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 508767001737 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 508767001738 active site 508767001739 putative substrate binding pocket [chemical binding]; other site 508767001740 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 508767001741 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 508767001742 active site 508767001743 putative substrate binding pocket [chemical binding]; other site 508767001744 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 508767001745 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 508767001746 active site 508767001747 FMN binding site [chemical binding]; other site 508767001748 substrate binding site [chemical binding]; other site 508767001749 4Fe-4S binding domain; Region: Fer4; pfam00037 508767001750 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 508767001751 homotrimer interaction site [polypeptide binding]; other site 508767001752 putative active site [active] 508767001753 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 508767001754 NTPase; Region: NTPase_1; cl17478 508767001755 phenylhydantoinase; Validated; Region: PRK08323 508767001756 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 508767001757 tetramer interface [polypeptide binding]; other site 508767001758 active site 508767001759 xanthine permease; Region: pbuX; TIGR03173 508767001760 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 508767001761 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 508767001762 catalytic loop [active] 508767001763 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 508767001764 iron binding site [ion binding]; other site 508767001765 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 508767001766 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 508767001767 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 508767001768 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 508767001769 nucleoside/Zn binding site; other site 508767001770 dimer interface [polypeptide binding]; other site 508767001771 catalytic motif [active] 508767001772 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 508767001773 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 508767001774 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 508767001775 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 508767001776 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 508767001777 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 508767001778 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 508767001779 catalytic loop [active] 508767001780 iron binding site [ion binding]; other site 508767001781 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 508767001782 xanthine permease; Region: pbuX; TIGR03173 508767001783 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 508767001784 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 508767001785 intersubunit interface [polypeptide binding]; other site 508767001786 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 508767001787 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508767001788 ABC-ATPase subunit interface; other site 508767001789 dimer interface [polypeptide binding]; other site 508767001790 putative PBP binding regions; other site 508767001791 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 508767001792 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 508767001793 Walker A/P-loop; other site 508767001794 ATP binding site [chemical binding]; other site 508767001795 Q-loop/lid; other site 508767001796 ABC transporter signature motif; other site 508767001797 Walker B; other site 508767001798 D-loop; other site 508767001799 H-loop/switch region; other site 508767001800 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 508767001801 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 508767001802 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 508767001803 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 508767001804 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 508767001805 CPxP motif; other site 508767001806 DsrE/DsrF-like family; Region: DrsE; pfam02635 508767001807 selenophosphate synthetase; Provisional; Region: PRK00943 508767001808 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 508767001809 dimerization interface [polypeptide binding]; other site 508767001810 putative ATP binding site [chemical binding]; other site 508767001811 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 508767001812 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 508767001813 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 508767001814 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 508767001815 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 508767001816 Ligand binding site; other site 508767001817 metal-binding site 508767001818 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 508767001819 XdhC Rossmann domain; Region: XdhC_C; pfam13478 508767001820 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 508767001821 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 508767001822 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 508767001823 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 508767001824 Walker A/P-loop; other site 508767001825 ATP binding site [chemical binding]; other site 508767001826 Q-loop/lid; other site 508767001827 ABC transporter signature motif; other site 508767001828 Walker B; other site 508767001829 D-loop; other site 508767001830 H-loop/switch region; other site 508767001831 cobalt transport protein CbiM; Validated; Region: PRK08319 508767001832 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 508767001833 cobalt transport protein CbiN; Provisional; Region: PRK02898 508767001834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 508767001835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 508767001836 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 508767001837 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 508767001838 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 508767001839 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 508767001840 FAD binding pocket [chemical binding]; other site 508767001841 FAD binding motif [chemical binding]; other site 508767001842 phosphate binding motif [ion binding]; other site 508767001843 beta-alpha-beta structure motif; other site 508767001844 NAD binding pocket [chemical binding]; other site 508767001845 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 508767001846 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 508767001847 catalytic loop [active] 508767001848 iron binding site [ion binding]; other site 508767001849 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 508767001850 PAS domain; Region: PAS; smart00091 508767001851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767001852 Walker A motif; other site 508767001853 ATP binding site [chemical binding]; other site 508767001854 Walker B motif; other site 508767001855 arginine finger; other site 508767001856 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 508767001857 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 508767001858 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 508767001859 putative NAD(P) binding site [chemical binding]; other site 508767001860 catalytic Zn binding site [ion binding]; other site 508767001861 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 508767001862 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 508767001863 FAD binding pocket [chemical binding]; other site 508767001864 FAD binding motif [chemical binding]; other site 508767001865 phosphate binding motif [ion binding]; other site 508767001866 beta-alpha-beta structure motif; other site 508767001867 NAD binding pocket [chemical binding]; other site 508767001868 Iron coordination center [ion binding]; other site 508767001869 putative oxidoreductase; Provisional; Region: PRK12831 508767001870 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508767001871 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508767001872 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508767001873 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 508767001874 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767001875 dimerization interface [polypeptide binding]; other site 508767001876 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767001877 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767001878 dimer interface [polypeptide binding]; other site 508767001879 putative CheW interface [polypeptide binding]; other site 508767001880 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 508767001881 active site 508767001882 Predicted membrane protein [Function unknown]; Region: COG3619 508767001883 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508767001884 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 508767001885 short chain dehydrogenase; Provisional; Region: PRK06701 508767001886 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 508767001887 NAD binding site [chemical binding]; other site 508767001888 metal binding site [ion binding]; metal-binding site 508767001889 active site 508767001890 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 508767001891 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 508767001892 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 508767001893 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 508767001894 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 508767001895 active site 508767001896 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 508767001897 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 508767001898 homotrimer interaction site [polypeptide binding]; other site 508767001899 putative active site [active] 508767001900 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 508767001901 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 508767001902 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 508767001903 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 508767001904 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 508767001905 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 508767001906 Walker A/P-loop; other site 508767001907 ATP binding site [chemical binding]; other site 508767001908 Q-loop/lid; other site 508767001909 ABC transporter signature motif; other site 508767001910 Walker B; other site 508767001911 D-loop; other site 508767001912 H-loop/switch region; other site 508767001913 Predicted transcriptional regulators [Transcription]; Region: COG1725 508767001914 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508767001915 DNA-binding site [nucleotide binding]; DNA binding site 508767001916 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767001917 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767001918 dimer interface [polypeptide binding]; other site 508767001919 putative CheW interface [polypeptide binding]; other site 508767001920 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 508767001921 DltD central region; Region: DltD_M; pfam04918 508767001922 DltD C-terminal region; Region: DltD_C; pfam04914 508767001923 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 508767001924 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 508767001925 acyl-activating enzyme (AAE) consensus motif; other site 508767001926 AMP binding site [chemical binding]; other site 508767001927 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 508767001928 Phosphopantetheine attachment site; Region: PP-binding; cl09936 508767001929 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 508767001930 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 508767001931 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 508767001932 putative active site [active] 508767001933 catalytic site [active] 508767001934 putative metal binding site [ion binding]; other site 508767001935 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 508767001936 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 508767001937 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 508767001938 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 508767001939 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508767001940 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 508767001941 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 508767001942 FAD binding pocket [chemical binding]; other site 508767001943 FAD binding motif [chemical binding]; other site 508767001944 phosphate binding motif [ion binding]; other site 508767001945 beta-alpha-beta structure motif; other site 508767001946 NAD binding pocket [chemical binding]; other site 508767001947 Iron coordination center [ion binding]; other site 508767001948 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 508767001949 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 508767001950 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508767001951 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508767001952 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 508767001953 ligand binding site [chemical binding]; other site 508767001954 flexible hinge region; other site 508767001955 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 508767001956 putative switch regulator; other site 508767001957 non-specific DNA interactions [nucleotide binding]; other site 508767001958 DNA binding site [nucleotide binding] 508767001959 sequence specific DNA binding site [nucleotide binding]; other site 508767001960 putative cAMP binding site [chemical binding]; other site 508767001961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508767001962 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508767001963 putative substrate translocation pore; other site 508767001964 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 508767001965 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 508767001966 Transcriptional regulator [Transcription]; Region: LysR; COG0583 508767001967 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 508767001968 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 508767001969 putative dimerization interface [polypeptide binding]; other site 508767001970 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 508767001971 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 508767001972 active site 508767001973 catalytic residue [active] 508767001974 dimer interface [polypeptide binding]; other site 508767001975 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 508767001976 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 508767001977 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 508767001978 shikimate binding site; other site 508767001979 NAD(P) binding site [chemical binding]; other site 508767001980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508767001981 putative substrate translocation pore; other site 508767001982 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508767001983 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 508767001984 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 508767001985 active site 508767001986 FMN binding site [chemical binding]; other site 508767001987 substrate binding site [chemical binding]; other site 508767001988 putative catalytic residue [active] 508767001989 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 508767001990 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508767001991 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508767001992 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 508767001993 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 508767001994 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 508767001995 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 508767001996 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 508767001997 N-acetyl-D-glucosamine binding site [chemical binding]; other site 508767001998 catalytic residue [active] 508767001999 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 508767002000 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508767002001 Zn2+ binding site [ion binding]; other site 508767002002 Mg2+ binding site [ion binding]; other site 508767002003 Protein of unknown function (DUF523); Region: DUF523; cl00733 508767002004 endonuclease IV; Provisional; Region: PRK01060 508767002005 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 508767002006 AP (apurinic/apyrimidinic) site pocket; other site 508767002007 DNA interaction; other site 508767002008 Metal-binding active site; metal-binding site 508767002009 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 508767002010 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 508767002011 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508767002012 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508767002013 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 508767002014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 508767002015 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 508767002016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508767002017 DNA-binding site [nucleotide binding]; DNA binding site 508767002018 UTRA domain; Region: UTRA; pfam07702 508767002019 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 508767002020 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 508767002021 active site 508767002022 dimer interface [polypeptide binding]; other site 508767002023 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 508767002024 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 508767002025 active site 508767002026 trimer interface [polypeptide binding]; other site 508767002027 allosteric site; other site 508767002028 active site lid [active] 508767002029 hexamer (dimer of trimers) interface [polypeptide binding]; other site 508767002030 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 508767002031 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 508767002032 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508767002033 active site turn [active] 508767002034 phosphorylation site [posttranslational modification] 508767002035 CutC family; Region: CutC; cl01218 508767002036 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 508767002037 biotin synthase; Region: bioB; TIGR00433 508767002038 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767002039 FeS/SAM binding site; other site 508767002040 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 508767002041 AAA domain; Region: AAA_26; pfam13500 508767002042 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 508767002043 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 508767002044 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 508767002045 DNA binding residues [nucleotide binding] 508767002046 dimer interface [polypeptide binding]; other site 508767002047 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 508767002048 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 508767002049 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 508767002050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767002051 Walker A/P-loop; other site 508767002052 ATP binding site [chemical binding]; other site 508767002053 Q-loop/lid; other site 508767002054 ABC transporter signature motif; other site 508767002055 Walker B; other site 508767002056 D-loop; other site 508767002057 H-loop/switch region; other site 508767002058 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 508767002059 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 508767002060 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 508767002061 Walker A/P-loop; other site 508767002062 ATP binding site [chemical binding]; other site 508767002063 Q-loop/lid; other site 508767002064 ABC transporter signature motif; other site 508767002065 Walker B; other site 508767002066 D-loop; other site 508767002067 H-loop/switch region; other site 508767002068 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 508767002069 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 508767002070 putative valine binding site [chemical binding]; other site 508767002071 dimer interface [polypeptide binding]; other site 508767002072 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 508767002073 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 508767002074 PYR/PP interface [polypeptide binding]; other site 508767002075 dimer interface [polypeptide binding]; other site 508767002076 TPP binding site [chemical binding]; other site 508767002077 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 508767002078 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 508767002079 TPP-binding site [chemical binding]; other site 508767002080 dimer interface [polypeptide binding]; other site 508767002081 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 508767002082 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508767002083 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767002084 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767002085 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 508767002086 Interdomain contacts; other site 508767002087 Cytokine receptor motif; other site 508767002088 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 508767002089 Interdomain contacts; other site 508767002090 Cytokine receptor motif; other site 508767002091 Peptidase M60-like family; Region: M60-like; pfam13402 508767002092 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 508767002093 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 508767002094 5' RNA guide strand anchoring site; other site 508767002095 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767002096 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767002097 dimer interface [polypeptide binding]; other site 508767002098 putative CheW interface [polypeptide binding]; other site 508767002099 Predicted membrane protein [Function unknown]; Region: COG1289 508767002100 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 508767002101 T-box leader 508767002102 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 508767002103 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 508767002104 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508767002105 ligand binding site [chemical binding]; other site 508767002106 flexible hinge region; other site 508767002107 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 508767002108 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 508767002109 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 508767002110 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 508767002111 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 508767002112 intersubunit interface [polypeptide binding]; other site 508767002113 active site 508767002114 catalytic residue [active] 508767002115 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 508767002116 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 508767002117 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 508767002118 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 508767002119 hybrid cluster protein; Provisional; Region: PRK05290 508767002120 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508767002121 ACS interaction site; other site 508767002122 CODH interaction site; other site 508767002123 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 508767002124 hybrid metal cluster; other site 508767002125 Predicted membrane protein [Function unknown]; Region: COG2364 508767002126 Accessory gene regulator B; Region: AgrB; pfam04647 508767002127 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767002128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767002129 ATP binding site [chemical binding]; other site 508767002130 Mg2+ binding site [ion binding]; other site 508767002131 G-X-G motif; other site 508767002132 Uncharacterized conserved protein [Function unknown]; Region: COG3339 508767002133 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 508767002134 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 508767002135 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 508767002136 RNA/DNA hybrid binding site [nucleotide binding]; other site 508767002137 active site 508767002138 YtxH-like protein; Region: YtxH; pfam12732 508767002139 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 508767002140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508767002141 non-specific DNA binding site [nucleotide binding]; other site 508767002142 salt bridge; other site 508767002143 sequence-specific DNA binding site [nucleotide binding]; other site 508767002144 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508767002145 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508767002146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508767002147 non-specific DNA binding site [nucleotide binding]; other site 508767002148 salt bridge; other site 508767002149 sequence-specific DNA binding site [nucleotide binding]; other site 508767002150 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508767002151 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508767002152 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 508767002153 Clp amino terminal domain; Region: Clp_N; pfam02861 508767002154 Clp amino terminal domain; Region: Clp_N; pfam02861 508767002155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767002156 Walker A motif; other site 508767002157 ATP binding site [chemical binding]; other site 508767002158 Walker B motif; other site 508767002159 arginine finger; other site 508767002160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767002161 Walker A motif; other site 508767002162 ATP binding site [chemical binding]; other site 508767002163 Walker B motif; other site 508767002164 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 508767002165 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 508767002166 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 508767002167 putative active site pocket [active] 508767002168 cleavage site 508767002169 Predicted membrane protein [Function unknown]; Region: COG4684 508767002170 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 508767002171 NAD synthetase; Reviewed; Region: nadE; cl17435 508767002172 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 508767002173 Ligand Binding Site [chemical binding]; other site 508767002174 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 508767002175 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508767002176 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508767002177 metal binding site [ion binding]; metal-binding site 508767002178 active site 508767002179 I-site; other site 508767002180 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 508767002181 T-box leader 508767002182 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 508767002183 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 508767002184 NodB motif; other site 508767002185 active site 508767002186 catalytic site [active] 508767002187 Zn binding site [ion binding]; other site 508767002188 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508767002189 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508767002190 metal binding site [ion binding]; metal-binding site 508767002191 active site 508767002192 I-site; other site 508767002193 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 508767002194 GAF domain; Region: GAF_3; pfam13492 508767002195 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 508767002196 trimer interface [polypeptide binding]; other site 508767002197 active site 508767002198 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 508767002199 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508767002200 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508767002201 ABC transporter; Region: ABC_tran_2; pfam12848 508767002202 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508767002203 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 508767002204 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 508767002205 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 508767002206 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 508767002207 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 508767002208 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 508767002209 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508767002210 catalytic residue [active] 508767002211 6-phosphofructokinase; Provisional; Region: PRK14072 508767002212 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 508767002213 active site 508767002214 ADP/pyrophosphate binding site [chemical binding]; other site 508767002215 dimerization interface [polypeptide binding]; other site 508767002216 allosteric effector site; other site 508767002217 fructose-1,6-bisphosphate binding site; other site 508767002218 Predicted membrane protein [Function unknown]; Region: COG1971 508767002219 ferric uptake regulator; Provisional; Region: fur; PRK09462 508767002220 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 508767002221 metal binding site 2 [ion binding]; metal-binding site 508767002222 putative DNA binding helix; other site 508767002223 metal binding site 1 [ion binding]; metal-binding site 508767002224 dimer interface [polypeptide binding]; other site 508767002225 structural Zn2+ binding site [ion binding]; other site 508767002226 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 508767002227 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508767002228 ABC-ATPase subunit interface; other site 508767002229 dimer interface [polypeptide binding]; other site 508767002230 putative PBP binding regions; other site 508767002231 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 508767002232 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 508767002233 oligoendopeptidase F; Region: pepF; TIGR00181 508767002234 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 508767002235 active site 508767002236 Zn binding site [ion binding]; other site 508767002237 Rhomboid family; Region: Rhomboid; pfam01694 508767002238 glutamate dehydrogenase; Provisional; Region: PRK09414 508767002239 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 508767002240 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 508767002241 NAD(P) binding site [chemical binding]; other site 508767002242 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 508767002243 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 508767002244 DXD motif; other site 508767002245 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 508767002246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767002247 ATP binding site [chemical binding]; other site 508767002248 Mg2+ binding site [ion binding]; other site 508767002249 G-X-G motif; other site 508767002250 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 508767002251 anchoring element; other site 508767002252 dimer interface [polypeptide binding]; other site 508767002253 ATP binding site [chemical binding]; other site 508767002254 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 508767002255 active site 508767002256 metal binding site [ion binding]; metal-binding site 508767002257 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 508767002258 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 508767002259 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 508767002260 CAP-like domain; other site 508767002261 active site 508767002262 primary dimer interface [polypeptide binding]; other site 508767002263 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508767002264 DJ-1 family protein; Region: not_thiJ; TIGR01383 508767002265 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 508767002266 conserved cys residue [active] 508767002267 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 508767002268 DHH family; Region: DHH; pfam01368 508767002269 DHHA1 domain; Region: DHHA1; pfam02272 508767002270 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 508767002271 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 508767002272 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 508767002273 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 508767002274 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 508767002275 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 508767002276 active site 508767002277 homodimer interface [polypeptide binding]; other site 508767002278 flavodoxin; Provisional; Region: PRK05569 508767002279 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 508767002280 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 508767002281 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 508767002282 dimer interface [polypeptide binding]; other site 508767002283 PYR/PP interface [polypeptide binding]; other site 508767002284 TPP binding site [chemical binding]; other site 508767002285 substrate binding site [chemical binding]; other site 508767002286 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 508767002287 Domain of unknown function; Region: EKR; smart00890 508767002288 4Fe-4S binding domain; Region: Fer4_6; pfam12837 508767002289 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 508767002290 TPP-binding site [chemical binding]; other site 508767002291 dimer interface [polypeptide binding]; other site 508767002292 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 508767002293 aspartate aminotransferase; Provisional; Region: PRK05764 508767002294 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508767002295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767002296 homodimer interface [polypeptide binding]; other site 508767002297 catalytic residue [active] 508767002298 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 508767002299 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 508767002300 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 508767002301 substrate-cofactor binding pocket; other site 508767002302 homodimer interface [polypeptide binding]; other site 508767002303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767002304 catalytic residue [active] 508767002305 Uncharacterized conserved protein [Function unknown]; Region: COG1315 508767002306 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 508767002307 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13490 508767002308 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 508767002309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767002310 active site 508767002311 phosphorylation site [posttranslational modification] 508767002312 intermolecular recognition site; other site 508767002313 dimerization interface [polypeptide binding]; other site 508767002314 CheB methylesterase; Region: CheB_methylest; pfam01339 508767002315 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 508767002316 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 508767002317 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 508767002318 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 508767002319 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 508767002320 putative binding surface; other site 508767002321 active site 508767002322 P2 response regulator binding domain; Region: P2; pfam07194 508767002323 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 508767002324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767002325 ATP binding site [chemical binding]; other site 508767002326 Mg2+ binding site [ion binding]; other site 508767002327 G-X-G motif; other site 508767002328 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 508767002329 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 508767002330 CheC-like family; Region: CheC; pfam04509 508767002331 CheC-like family; Region: CheC; pfam04509 508767002332 Response regulator receiver domain; Region: Response_reg; pfam00072 508767002333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767002334 active site 508767002335 phosphorylation site [posttranslational modification] 508767002336 intermolecular recognition site; other site 508767002337 dimerization interface [polypeptide binding]; other site 508767002338 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 508767002339 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 508767002340 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 508767002341 flagellar motor switch protein; Validated; Region: PRK08119 508767002342 CheC-like family; Region: CheC; pfam04509 508767002343 CheC-like family; Region: CheC; pfam04509 508767002344 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 508767002345 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 508767002346 FlgN protein; Region: FlgN; pfam05130 508767002347 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 508767002348 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 508767002349 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 508767002350 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 508767002351 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 508767002352 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 508767002353 flagellar assembly protein FliW; Provisional; Region: PRK13285 508767002354 carbon storage regulator; Provisional; Region: PRK01712 508767002355 FlaG protein; Region: FlaG; pfam03646 508767002356 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 508767002357 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 508767002358 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 508767002359 Putative motility protein; Region: YjfB_motility; pfam14070 508767002360 flagellin; Provisional; Region: PRK12804 508767002361 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 508767002362 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 508767002363 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 508767002364 putative metal binding site; other site 508767002365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508767002366 binding surface 508767002367 TPR motif; other site 508767002368 flagellin; Provisional; Region: PRK12804 508767002369 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 508767002370 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 508767002371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 508767002372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 508767002373 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 508767002374 ATP-grasp domain; Region: ATP-grasp_4; cl17255 508767002375 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 508767002376 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767002377 motif II; other site 508767002378 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 508767002379 ligand binding site; other site 508767002380 Methyltransferase domain; Region: Methyltransf_23; pfam13489 508767002381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767002382 S-adenosylmethionine binding site [chemical binding]; other site 508767002383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 508767002384 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 508767002385 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 508767002386 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 508767002387 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 508767002388 pseudaminic acid synthase; Region: PseI; TIGR03586 508767002389 NeuB family; Region: NeuB; pfam03102 508767002390 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 508767002391 NeuB binding interface [polypeptide binding]; other site 508767002392 putative substrate binding site [chemical binding]; other site 508767002393 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 508767002394 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 508767002395 NAD(P) binding site [chemical binding]; other site 508767002396 homodimer interface [polypeptide binding]; other site 508767002397 substrate binding site [chemical binding]; other site 508767002398 active site 508767002399 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 508767002400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508767002401 NAD(P) binding site [chemical binding]; other site 508767002402 active site 508767002403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508767002404 binding surface 508767002405 TPR motif; other site 508767002406 Sulfatase; Region: Sulfatase; cl17466 508767002407 flagellin; Provisional; Region: PRK12804 508767002408 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 508767002409 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 508767002410 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623 508767002411 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12630 508767002412 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 508767002413 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 508767002414 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 508767002415 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 508767002416 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 508767002417 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 508767002418 FliG C-terminal domain; Region: FliG_C; pfam01706 508767002419 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 508767002420 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 508767002421 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 508767002422 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 508767002423 Walker A motif/ATP binding site; other site 508767002424 Walker B motif; other site 508767002425 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 508767002426 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 508767002427 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 508767002428 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 508767002429 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 508767002430 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 508767002431 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 508767002432 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 508767002433 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 508767002434 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 508767002435 Flagellar protein (FlbD); Region: FlbD; pfam06289 508767002436 flagellar motor protein MotP; Reviewed; Region: PRK06926 508767002437 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 508767002438 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 508767002439 flagellar motor protein MotS; Reviewed; Region: PRK06925 508767002440 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 508767002441 ligand binding site [chemical binding]; other site 508767002442 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 508767002443 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 508767002444 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 508767002445 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 508767002446 bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772 508767002447 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 508767002448 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 508767002449 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 508767002450 FHIPEP family; Region: FHIPEP; pfam00771 508767002451 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 508767002452 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 508767002453 GTP/Mg2+ binding site [chemical binding]; other site 508767002454 G4 box; other site 508767002455 G5 box; other site 508767002456 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 508767002457 G1 box; other site 508767002458 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 508767002459 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 508767002460 P-loop; other site 508767002461 Flagellar protein YcgR; Region: YcgR_2; pfam12945 508767002462 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 508767002463 PilZ domain; Region: PilZ; pfam07238 508767002464 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 508767002465 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508767002466 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 508767002467 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508767002468 DNA binding residues [nucleotide binding] 508767002469 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 508767002470 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 508767002471 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 508767002472 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 508767002473 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 508767002474 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 508767002475 DRTGG domain; Region: DRTGG; pfam07085 508767002476 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 508767002477 DHHA2 domain; Region: DHHA2; pfam02833 508767002478 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 508767002479 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 508767002480 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508767002481 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 508767002482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767002483 motif II; other site 508767002484 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 508767002485 clostridium toxin-associated regulator BotR; Region: P21_Cbot; TIGR03209 508767002486 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508767002487 DNA binding residues [nucleotide binding] 508767002488 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 508767002489 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 508767002490 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 508767002491 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 508767002492 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 508767002493 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 508767002494 anti sigma factor interaction site; other site 508767002495 regulatory phosphorylation site [posttranslational modification]; other site 508767002496 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 508767002497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767002498 ATP binding site [chemical binding]; other site 508767002499 Mg2+ binding site [ion binding]; other site 508767002500 G-X-G motif; other site 508767002501 sporulation sigma factor SigF; Validated; Region: PRK05572 508767002502 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508767002503 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 508767002504 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508767002505 DNA binding residues [nucleotide binding] 508767002506 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 508767002507 stage V sporulation protein AD; Validated; Region: PRK08304 508767002508 stage V sporulation protein AD; Provisional; Region: PRK12404 508767002509 SpoVA protein; Region: SpoVA; cl04298 508767002510 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 508767002511 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 508767002512 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508767002513 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 508767002514 Competence protein; Region: Competence; pfam03772 508767002515 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 508767002516 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 508767002517 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 508767002518 germination protease; Provisional; Region: PRK12362 508767002519 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 508767002520 stage II sporulation protein P; Region: spore_II_P; TIGR02867 508767002521 GTP-binding protein LepA; Provisional; Region: PRK05433 508767002522 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 508767002523 G1 box; other site 508767002524 putative GEF interaction site [polypeptide binding]; other site 508767002525 GTP/Mg2+ binding site [chemical binding]; other site 508767002526 Switch I region; other site 508767002527 G2 box; other site 508767002528 G3 box; other site 508767002529 Switch II region; other site 508767002530 G4 box; other site 508767002531 G5 box; other site 508767002532 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 508767002533 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 508767002534 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 508767002535 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 508767002536 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767002537 FeS/SAM binding site; other site 508767002538 HemN C-terminal domain; Region: HemN_C; pfam06969 508767002539 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 508767002540 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 508767002541 GrpE; Region: GrpE; pfam01025 508767002542 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 508767002543 dimer interface [polypeptide binding]; other site 508767002544 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 508767002545 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 508767002546 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 508767002547 nucleotide binding site [chemical binding]; other site 508767002548 NEF interaction site [polypeptide binding]; other site 508767002549 SBD interface [polypeptide binding]; other site 508767002550 chaperone protein DnaJ; Provisional; Region: PRK14297 508767002551 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 508767002552 HSP70 interaction site [polypeptide binding]; other site 508767002553 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 508767002554 substrate binding site [polypeptide binding]; other site 508767002555 dimer interface [polypeptide binding]; other site 508767002556 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 508767002557 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 508767002558 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 508767002559 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 508767002560 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 508767002561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767002562 S-adenosylmethionine binding site [chemical binding]; other site 508767002563 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 508767002564 RNA methyltransferase, RsmE family; Region: TIGR00046 508767002565 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 508767002566 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 508767002567 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 508767002568 nucleotide binding site/active site [active] 508767002569 HIT family signature motif; other site 508767002570 catalytic residue [active] 508767002571 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 508767002572 Yqey-like protein; Region: YqeY; pfam09424 508767002573 YabP family; Region: YabP; cl06766 508767002574 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 508767002575 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 508767002576 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 508767002577 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 508767002578 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508767002579 Zn2+ binding site [ion binding]; other site 508767002580 Mg2+ binding site [ion binding]; other site 508767002581 metal-binding heat shock protein; Provisional; Region: PRK00016 508767002582 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 508767002583 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 508767002584 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 508767002585 active site 508767002586 GTPase Era; Reviewed; Region: era; PRK00089 508767002587 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 508767002588 G1 box; other site 508767002589 GTP/Mg2+ binding site [chemical binding]; other site 508767002590 Switch I region; other site 508767002591 G2 box; other site 508767002592 Switch II region; other site 508767002593 G3 box; other site 508767002594 G4 box; other site 508767002595 G5 box; other site 508767002596 KH domain; Region: KH_2; pfam07650 508767002597 Recombination protein O N terminal; Region: RecO_N; pfam11967 508767002598 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 508767002599 Recombination protein O C terminal; Region: RecO_C; pfam02565 508767002600 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 508767002601 HTH domain; Region: HTH_11; pfam08279 508767002602 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 508767002603 FOG: CBS domain [General function prediction only]; Region: COG0517 508767002604 pyruvate phosphate dikinase; Provisional; Region: PRK09279 508767002605 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 508767002606 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 508767002607 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 508767002608 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 508767002609 Ecdysteroid kinase; Region: EcKinase; cl17738 508767002610 spore coat protein YutH; Region: spore_yutH; TIGR02905 508767002611 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 508767002612 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508767002613 Zn2+ binding site [ion binding]; other site 508767002614 Mg2+ binding site [ion binding]; other site 508767002615 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 508767002616 DNA primase; Validated; Region: dnaG; PRK05667 508767002617 CHC2 zinc finger; Region: zf-CHC2; pfam01807 508767002618 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 508767002619 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 508767002620 active site 508767002621 metal binding site [ion binding]; metal-binding site 508767002622 interdomain interaction site; other site 508767002623 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 508767002624 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 508767002625 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 508767002626 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 508767002627 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 508767002628 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508767002629 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 508767002630 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508767002631 DNA binding residues [nucleotide binding] 508767002632 Family of unknown function (DUF633); Region: DUF633; pfam04816 508767002633 Uncharacterized conserved protein [Function unknown]; Region: COG0327 508767002634 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 508767002635 Domain of unknown function (DUF955); Region: DUF955; pfam06114 508767002636 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 508767002637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508767002638 non-specific DNA binding site [nucleotide binding]; other site 508767002639 salt bridge; other site 508767002640 sequence-specific DNA binding site [nucleotide binding]; other site 508767002641 Homeodomain-like domain; Region: HTH_23; pfam13384 508767002642 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 508767002643 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 508767002644 Phage XkdN-like protein; Region: XkdN; pfam08890 508767002645 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 508767002646 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 508767002647 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 508767002648 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 508767002649 V-type ATP synthase subunit I; Validated; Region: PRK05771 508767002650 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 508767002651 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 508767002652 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 508767002653 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 508767002654 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 508767002655 active site 508767002656 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 508767002657 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 508767002658 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 508767002659 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 508767002660 Walker A/P-loop; other site 508767002661 ATP binding site [chemical binding]; other site 508767002662 Q-loop/lid; other site 508767002663 ABC transporter signature motif; other site 508767002664 Walker B; other site 508767002665 D-loop; other site 508767002666 H-loop/switch region; other site 508767002667 TOBE domain; Region: TOBE_2; pfam08402 508767002668 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 508767002669 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508767002670 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508767002671 DNA binding site [nucleotide binding] 508767002672 domain linker motif; other site 508767002673 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 508767002674 dimerization interface [polypeptide binding]; other site 508767002675 ligand binding site [chemical binding]; other site 508767002676 4-alpha-glucanotransferase; Provisional; Region: PRK14508 508767002677 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 508767002678 homodimer interface [polypeptide binding]; other site 508767002679 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 508767002680 active site pocket [active] 508767002681 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 508767002682 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 508767002683 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508767002684 potassium-transporting ATPase subunit C; Provisional; Region: PRK13996 508767002685 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 508767002686 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 508767002687 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 508767002688 Ligand Binding Site [chemical binding]; other site 508767002689 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 508767002690 GAF domain; Region: GAF_3; pfam13492 508767002691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767002692 dimer interface [polypeptide binding]; other site 508767002693 phosphorylation site [posttranslational modification] 508767002694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767002695 ATP binding site [chemical binding]; other site 508767002696 G-X-G motif; other site 508767002697 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767002698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767002699 active site 508767002700 phosphorylation site [posttranslational modification] 508767002701 intermolecular recognition site; other site 508767002702 dimerization interface [polypeptide binding]; other site 508767002703 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767002704 DNA binding site [nucleotide binding] 508767002705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767002706 S-adenosylmethionine binding site [chemical binding]; other site 508767002707 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 508767002708 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 508767002709 putative ligand binding site [chemical binding]; other site 508767002710 putative NAD binding site [chemical binding]; other site 508767002711 catalytic site [active] 508767002712 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 508767002713 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767002714 active site 508767002715 motif I; other site 508767002716 motif II; other site 508767002717 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 508767002718 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 508767002719 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 508767002720 active site 508767002721 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 508767002722 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767002723 Coenzyme A binding pocket [chemical binding]; other site 508767002724 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 508767002725 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 508767002726 Acylphosphatase; Region: Acylphosphatase; cl00551 508767002727 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 508767002728 active site 508767002729 multimer interface [polypeptide binding]; other site 508767002730 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 508767002731 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 508767002732 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 508767002733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767002734 dimer interface [polypeptide binding]; other site 508767002735 conserved gate region; other site 508767002736 putative PBP binding loops; other site 508767002737 ABC-ATPase subunit interface; other site 508767002738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767002739 dimer interface [polypeptide binding]; other site 508767002740 conserved gate region; other site 508767002741 putative PBP binding loops; other site 508767002742 ABC-ATPase subunit interface; other site 508767002743 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 508767002744 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 508767002745 Walker A/P-loop; other site 508767002746 ATP binding site [chemical binding]; other site 508767002747 Q-loop/lid; other site 508767002748 ABC transporter signature motif; other site 508767002749 Walker B; other site 508767002750 D-loop; other site 508767002751 H-loop/switch region; other site 508767002752 TOBE domain; Region: TOBE_2; pfam08402 508767002753 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 508767002754 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508767002755 non-specific DNA binding site [nucleotide binding]; other site 508767002756 salt bridge; other site 508767002757 sequence-specific DNA binding site [nucleotide binding]; other site 508767002758 Cupin domain; Region: Cupin_2; pfam07883 508767002759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508767002760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767002761 Coenzyme A binding pocket [chemical binding]; other site 508767002762 Putative amidotransferase; Region: DUF4066; pfam13278 508767002763 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 508767002764 amino acid carrier protein; Region: agcS; TIGR00835 508767002765 Transglycosylase; Region: Transgly; pfam00912 508767002766 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 508767002767 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 508767002768 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 508767002769 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508767002770 active site 508767002771 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 508767002772 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 508767002773 HflX GTPase family; Region: HflX; cd01878 508767002774 G1 box; other site 508767002775 GTP/Mg2+ binding site [chemical binding]; other site 508767002776 Switch I region; other site 508767002777 G2 box; other site 508767002778 G3 box; other site 508767002779 Switch II region; other site 508767002780 G4 box; other site 508767002781 G5 box; other site 508767002782 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 508767002783 active site 508767002784 NTP binding site [chemical binding]; other site 508767002785 metal binding triad [ion binding]; metal-binding site 508767002786 antibiotic binding site [chemical binding]; other site 508767002787 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 508767002788 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508767002789 DNA-binding site [nucleotide binding]; DNA binding site 508767002790 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508767002791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767002792 homodimer interface [polypeptide binding]; other site 508767002793 catalytic residue [active] 508767002794 Uncharacterized conserved protein [Function unknown]; Region: COG1739 508767002795 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 508767002796 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 508767002797 hypothetical protein; Validated; Region: PRK00110 508767002798 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 508767002799 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 508767002800 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 508767002801 homodimer interface [polypeptide binding]; other site 508767002802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767002803 catalytic residue [active] 508767002804 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 508767002805 spermidine synthase; Provisional; Region: PRK00811 508767002806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767002807 S-adenosylmethionine binding site [chemical binding]; other site 508767002808 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 508767002809 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 508767002810 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 508767002811 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 508767002812 dimer interface [polypeptide binding]; other site 508767002813 active site 508767002814 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 508767002815 catalytic residues [active] 508767002816 substrate binding site [chemical binding]; other site 508767002817 PAS domain; Region: PAS; smart00091 508767002818 PAS fold; Region: PAS_4; pfam08448 508767002819 putative active site [active] 508767002820 heme pocket [chemical binding]; other site 508767002821 GAF domain; Region: GAF; pfam01590 508767002822 PAS domain S-box; Region: sensory_box; TIGR00229 508767002823 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 508767002824 putative active site [active] 508767002825 heme pocket [chemical binding]; other site 508767002826 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767002827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767002828 dimer interface [polypeptide binding]; other site 508767002829 phosphorylation site [posttranslational modification] 508767002830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767002831 ATP binding site [chemical binding]; other site 508767002832 Mg2+ binding site [ion binding]; other site 508767002833 G-X-G motif; other site 508767002834 agmatinase; Region: agmatinase; TIGR01230 508767002835 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 508767002836 putative active site [active] 508767002837 Mn binding site [ion binding]; other site 508767002838 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 508767002839 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 508767002840 dimer interface [polypeptide binding]; other site 508767002841 active site 508767002842 metal binding site [ion binding]; metal-binding site 508767002843 Cache domain; Region: Cache_1; pfam02743 508767002844 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767002845 dimerization interface [polypeptide binding]; other site 508767002846 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767002847 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767002848 dimer interface [polypeptide binding]; other site 508767002849 putative CheW interface [polypeptide binding]; other site 508767002850 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 508767002851 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767002852 FeS/SAM binding site; other site 508767002853 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 508767002854 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 508767002855 RuvA N terminal domain; Region: RuvA_N; pfam01330 508767002856 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 508767002857 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 508767002858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767002859 Walker A motif; other site 508767002860 ATP binding site [chemical binding]; other site 508767002861 Walker B motif; other site 508767002862 arginine finger; other site 508767002863 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 508767002864 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 508767002865 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 508767002866 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 508767002867 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 508767002868 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 508767002869 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 508767002870 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 508767002871 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 508767002872 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 508767002873 Protein export membrane protein; Region: SecD_SecF; pfam02355 508767002874 DHH family; Region: DHH; pfam01368 508767002875 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508767002876 active site 508767002877 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 508767002878 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508767002879 Zn2+ binding site [ion binding]; other site 508767002880 Mg2+ binding site [ion binding]; other site 508767002881 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 508767002882 synthetase active site [active] 508767002883 NTP binding site [chemical binding]; other site 508767002884 metal binding site [ion binding]; metal-binding site 508767002885 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 508767002886 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 508767002887 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 508767002888 putative active site [active] 508767002889 dimerization interface [polypeptide binding]; other site 508767002890 putative tRNAtyr binding site [nucleotide binding]; other site 508767002891 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 508767002892 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 508767002893 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 508767002894 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767002895 FeS/SAM binding site; other site 508767002896 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 508767002897 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 508767002898 dimer interface [polypeptide binding]; other site 508767002899 motif 1; other site 508767002900 active site 508767002901 motif 2; other site 508767002902 motif 3; other site 508767002903 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 508767002904 anticodon binding site; other site 508767002905 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 508767002906 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 508767002907 dimer interface [polypeptide binding]; other site 508767002908 anticodon binding site; other site 508767002909 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 508767002910 homodimer interface [polypeptide binding]; other site 508767002911 motif 1; other site 508767002912 active site 508767002913 motif 2; other site 508767002914 GAD domain; Region: GAD; pfam02938 508767002915 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 508767002916 active site 508767002917 motif 3; other site 508767002918 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 508767002919 Protein of unknown function (DUF554); Region: DUF554; pfam04474 508767002920 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 508767002921 active site residue [active] 508767002922 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508767002923 dimerization interface [polypeptide binding]; other site 508767002924 putative DNA binding site [nucleotide binding]; other site 508767002925 putative Zn2+ binding site [ion binding]; other site 508767002926 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 508767002927 homoserine dehydrogenase; Provisional; Region: PRK06349 508767002928 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 508767002929 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 508767002930 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 508767002931 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 508767002932 glycerol kinase; Provisional; Region: glpK; PRK00047 508767002933 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 508767002934 N- and C-terminal domain interface [polypeptide binding]; other site 508767002935 active site 508767002936 MgATP binding site [chemical binding]; other site 508767002937 catalytic site [active] 508767002938 metal binding site [ion binding]; metal-binding site 508767002939 glycerol binding site [chemical binding]; other site 508767002940 homotetramer interface [polypeptide binding]; other site 508767002941 homodimer interface [polypeptide binding]; other site 508767002942 FBP binding site [chemical binding]; other site 508767002943 protein IIAGlc interface [polypeptide binding]; other site 508767002944 Predicted dehydrogenase [General function prediction only]; Region: COG0579 508767002945 hydroxyglutarate oxidase; Provisional; Region: PRK11728 508767002946 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 508767002947 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 508767002948 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508767002949 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 508767002950 aspartate kinase; Reviewed; Region: PRK09034 508767002951 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 508767002952 nucleotide binding site [chemical binding]; other site 508767002953 substrate binding site [chemical binding]; other site 508767002954 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 508767002955 allosteric regulatory residue; other site 508767002956 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 508767002957 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 508767002958 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 508767002959 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 508767002960 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 508767002961 ANTAR domain; Region: ANTAR; pfam03861 508767002962 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 508767002963 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 508767002964 active site 508767002965 dimer interface [polypeptide binding]; other site 508767002966 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 508767002967 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 508767002968 active site 508767002969 FMN binding site [chemical binding]; other site 508767002970 substrate binding site [chemical binding]; other site 508767002971 3Fe-4S cluster binding site [ion binding]; other site 508767002972 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 508767002973 domain interface; other site 508767002974 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 508767002975 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508767002976 inner membrane transporter YjeM; Provisional; Region: PRK15238 508767002977 DNA-directed RNA polymerase subunit beta'/alpha domain fusion protein; Provisional; Region: PRK14906 508767002978 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 508767002979 Rubrerythrin [Energy production and conversion]; Region: COG1592 508767002980 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 508767002981 binuclear metal center [ion binding]; other site 508767002982 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 508767002983 iron binding site [ion binding]; other site 508767002984 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 508767002985 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 508767002986 ATP-binding site [chemical binding]; other site 508767002987 Sugar specificity; other site 508767002988 Pyrimidine base specificity; other site 508767002989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 508767002990 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 508767002991 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 508767002992 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 508767002993 PhoU domain; Region: PhoU; pfam01895 508767002994 PhoU domain; Region: PhoU; pfam01895 508767002995 ribonuclease Z; Reviewed; Region: PRK00055 508767002996 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 508767002997 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 508767002998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767002999 motif II; other site 508767003000 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 508767003001 Domain of unknown function DUF20; Region: UPF0118; pfam01594 508767003002 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 508767003003 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; pfam03738 508767003004 Cache domain; Region: Cache_1; pfam02743 508767003005 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767003006 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767003007 dimer interface [polypeptide binding]; other site 508767003008 putative CheW interface [polypeptide binding]; other site 508767003009 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 508767003010 catalytic residues [active] 508767003011 threonine dehydratase; Provisional; Region: PRK08198 508767003012 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 508767003013 tetramer interface [polypeptide binding]; other site 508767003014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767003015 catalytic residue [active] 508767003016 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 508767003017 Uncharacterized conserved protein [Function unknown]; Region: COG2966 508767003018 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 508767003019 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 508767003020 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 508767003021 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 508767003022 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 508767003023 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 508767003024 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 508767003025 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 508767003026 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508767003027 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508767003028 ABC transporter; Region: ABC_tran_2; pfam12848 508767003029 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508767003030 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 508767003031 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 508767003032 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 508767003033 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 508767003034 dimer interface [polypeptide binding]; other site 508767003035 active site 508767003036 glycine-pyridoxal phosphate binding site [chemical binding]; other site 508767003037 folate binding site [chemical binding]; other site 508767003038 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 508767003039 putative active site [active] 508767003040 putative metal binding site [ion binding]; other site 508767003041 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 508767003042 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 508767003043 active site 508767003044 dimer interface [polypeptide binding]; other site 508767003045 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 508767003046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508767003047 NAD(P) binding site [chemical binding]; other site 508767003048 active site 508767003049 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 508767003050 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 508767003051 homodimer interface [polypeptide binding]; other site 508767003052 substrate-cofactor binding pocket; other site 508767003053 catalytic residue [active] 508767003054 NAD synthetase; Reviewed; Region: nadE; PRK02628 508767003055 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 508767003056 multimer interface [polypeptide binding]; other site 508767003057 active site 508767003058 catalytic triad [active] 508767003059 protein interface 1 [polypeptide binding]; other site 508767003060 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 508767003061 homodimer interface [polypeptide binding]; other site 508767003062 NAD binding pocket [chemical binding]; other site 508767003063 ATP binding pocket [chemical binding]; other site 508767003064 Mg binding site [ion binding]; other site 508767003065 active-site loop [active] 508767003066 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 508767003067 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 508767003068 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 508767003069 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 508767003070 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 508767003071 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508767003072 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 508767003073 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 508767003074 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 508767003075 DNA binding residues [nucleotide binding] 508767003076 dimer interface [polypeptide binding]; other site 508767003077 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 508767003078 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 508767003079 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 508767003080 substrate binding pocket [chemical binding]; other site 508767003081 membrane-bound complex binding site; other site 508767003082 hinge residues; other site 508767003083 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 508767003084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767003085 dimer interface [polypeptide binding]; other site 508767003086 conserved gate region; other site 508767003087 putative PBP binding loops; other site 508767003088 ABC-ATPase subunit interface; other site 508767003089 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 508767003090 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 508767003091 Walker A/P-loop; other site 508767003092 ATP binding site [chemical binding]; other site 508767003093 Q-loop/lid; other site 508767003094 ABC transporter signature motif; other site 508767003095 Walker B; other site 508767003096 D-loop; other site 508767003097 H-loop/switch region; other site 508767003098 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508767003099 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 508767003100 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 508767003101 Cl- selectivity filter; other site 508767003102 Cl- binding residues [ion binding]; other site 508767003103 pore gating glutamate residue; other site 508767003104 dimer interface [polypeptide binding]; other site 508767003105 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 508767003106 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 508767003107 active site 508767003108 catalytic tetrad [active] 508767003109 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 508767003110 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 508767003111 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 508767003112 dimerization interface [polypeptide binding]; other site 508767003113 ATP binding site [chemical binding]; other site 508767003114 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 508767003115 dimerization interface [polypeptide binding]; other site 508767003116 ATP binding site [chemical binding]; other site 508767003117 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 508767003118 putative active site [active] 508767003119 catalytic triad [active] 508767003120 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 508767003121 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 508767003122 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 508767003123 ATP binding site [chemical binding]; other site 508767003124 active site 508767003125 substrate binding site [chemical binding]; other site 508767003126 amidophosphoribosyltransferase; Provisional; Region: PRK05793 508767003127 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 508767003128 active site 508767003129 tetramer interface [polypeptide binding]; other site 508767003130 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508767003131 active site 508767003132 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 508767003133 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 508767003134 dimerization interface [polypeptide binding]; other site 508767003135 putative ATP binding site [chemical binding]; other site 508767003136 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 508767003137 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 508767003138 active site 508767003139 substrate binding site [chemical binding]; other site 508767003140 cosubstrate binding site; other site 508767003141 catalytic site [active] 508767003142 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 508767003143 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 508767003144 purine monophosphate binding site [chemical binding]; other site 508767003145 dimer interface [polypeptide binding]; other site 508767003146 putative catalytic residues [active] 508767003147 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 508767003148 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 508767003149 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 508767003150 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 508767003151 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 508767003152 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 508767003153 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 508767003154 CoA binding domain; Region: CoA_binding_2; pfam13380 508767003155 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 508767003156 LytTr DNA-binding domain; Region: LytTR; smart00850 508767003157 EDD domain protein, DegV family; Region: DegV; TIGR00762 508767003158 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 508767003159 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 508767003160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 508767003161 FtsX-like permease family; Region: FtsX; pfam02687 508767003162 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508767003163 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 508767003164 Walker A/P-loop; other site 508767003165 ATP binding site [chemical binding]; other site 508767003166 Q-loop/lid; other site 508767003167 ABC transporter signature motif; other site 508767003168 Walker B; other site 508767003169 D-loop; other site 508767003170 H-loop/switch region; other site 508767003171 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508767003172 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 508767003173 Walker A/P-loop; other site 508767003174 ATP binding site [chemical binding]; other site 508767003175 Q-loop/lid; other site 508767003176 ABC transporter signature motif; other site 508767003177 Walker B; other site 508767003178 D-loop; other site 508767003179 H-loop/switch region; other site 508767003180 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767003181 OpgC protein; Region: OpgC_C; cl17858 508767003182 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 508767003183 phosphorylation site [posttranslational modification] 508767003184 dimer interface [polypeptide binding]; other site 508767003185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767003186 ATP binding site [chemical binding]; other site 508767003187 Mg2+ binding site [ion binding]; other site 508767003188 G-X-G motif; other site 508767003189 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767003190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767003191 active site 508767003192 phosphorylation site [posttranslational modification] 508767003193 intermolecular recognition site; other site 508767003194 dimerization interface [polypeptide binding]; other site 508767003195 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767003196 DNA binding site [nucleotide binding] 508767003197 TraX protein; Region: TraX; cl05434 508767003198 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508767003199 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767003200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767003201 active site 508767003202 phosphorylation site [posttranslational modification] 508767003203 intermolecular recognition site; other site 508767003204 dimerization interface [polypeptide binding]; other site 508767003205 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767003206 DNA binding site [nucleotide binding] 508767003207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767003208 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767003209 dimerization interface [polypeptide binding]; other site 508767003210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767003211 dimer interface [polypeptide binding]; other site 508767003212 phosphorylation site [posttranslational modification] 508767003213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767003214 ATP binding site [chemical binding]; other site 508767003215 Mg2+ binding site [ion binding]; other site 508767003216 G-X-G motif; other site 508767003217 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 508767003218 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 508767003219 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 508767003220 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 508767003221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508767003222 putative substrate translocation pore; other site 508767003223 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 508767003224 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 508767003225 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 508767003226 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 508767003227 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 508767003228 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 508767003229 MarR family; Region: MarR_2; pfam12802 508767003230 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 508767003231 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508767003232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508767003233 DNA binding residues [nucleotide binding] 508767003234 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 508767003235 Uncharacterized conserved protein [Function unknown]; Region: COG0398 508767003236 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 508767003237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 508767003238 TPR repeat; Region: TPR_11; pfam13414 508767003239 binding surface 508767003240 TPR motif; other site 508767003241 TPR repeat; Region: TPR_11; pfam13414 508767003242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508767003243 binding surface 508767003244 TPR motif; other site 508767003245 TPR repeat; Region: TPR_11; pfam13414 508767003246 TPR repeat; Region: TPR_11; pfam13414 508767003247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508767003248 binding surface 508767003249 TPR motif; other site 508767003250 TPR repeat; Region: TPR_11; pfam13414 508767003251 Flavin Reductases; Region: FlaRed; cl00801 508767003252 MarR family; Region: MarR_2; pfam12802 508767003253 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 508767003254 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 508767003255 dimer interface [polypeptide binding]; other site 508767003256 active site 508767003257 CoA binding pocket [chemical binding]; other site 508767003258 acyl carrier protein; Provisional; Region: acpP; PRK00982 508767003259 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 508767003260 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 508767003261 FMN binding site [chemical binding]; other site 508767003262 substrate binding site [chemical binding]; other site 508767003263 putative catalytic residue [active] 508767003264 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 508767003265 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 508767003266 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 508767003267 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 508767003268 NAD(P) binding site [chemical binding]; other site 508767003269 homotetramer interface [polypeptide binding]; other site 508767003270 homodimer interface [polypeptide binding]; other site 508767003271 active site 508767003272 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 508767003273 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 508767003274 dimer interface [polypeptide binding]; other site 508767003275 active site 508767003276 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 508767003277 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 508767003278 carboxyltransferase (CT) interaction site; other site 508767003279 biotinylation site [posttranslational modification]; other site 508767003280 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 508767003281 biotin carboxylase; Validated; Region: PRK05586 508767003282 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 508767003283 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 508767003284 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 508767003285 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 508767003286 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 508767003287 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 508767003288 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 508767003289 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 508767003290 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 508767003291 hexamer interface [polypeptide binding]; other site 508767003292 RNA binding site [nucleotide binding]; other site 508767003293 Histidine-zinc binding site [chemical binding]; other site 508767003294 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 508767003295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508767003296 NAD(P) binding site [chemical binding]; other site 508767003297 active site 508767003298 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 508767003299 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 508767003300 zinc binding site [ion binding]; other site 508767003301 putative ligand binding site [chemical binding]; other site 508767003302 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 508767003303 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 508767003304 TM-ABC transporter signature motif; other site 508767003305 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 508767003306 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 508767003307 Walker A/P-loop; other site 508767003308 ATP binding site [chemical binding]; other site 508767003309 Q-loop/lid; other site 508767003310 ABC transporter signature motif; other site 508767003311 Walker B; other site 508767003312 D-loop; other site 508767003313 H-loop/switch region; other site 508767003314 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 508767003315 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 508767003316 catalytic loop [active] 508767003317 iron binding site [ion binding]; other site 508767003318 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 508767003319 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 508767003320 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 508767003321 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 508767003322 Ligand binding site; other site 508767003323 metal-binding site 508767003324 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 508767003325 putative MPT binding site; other site 508767003326 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 508767003327 trimer interface [polypeptide binding]; other site 508767003328 dimer interface [polypeptide binding]; other site 508767003329 putative active site [active] 508767003330 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 508767003331 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767003332 FeS/SAM binding site; other site 508767003333 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 508767003334 MOSC domain; Region: MOSC; pfam03473 508767003335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767003336 Walker A motif; other site 508767003337 ATP binding site [chemical binding]; other site 508767003338 Walker B motif; other site 508767003339 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 508767003340 DNA binding site [nucleotide binding] 508767003341 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508767003342 active site 508767003343 DNA binding site [nucleotide binding] 508767003344 Int/Topo IB signature motif; other site 508767003345 recombination factor protein RarA; Reviewed; Region: PRK13342 508767003346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767003347 Walker A motif; other site 508767003348 ATP binding site [chemical binding]; other site 508767003349 Walker B motif; other site 508767003350 arginine finger; other site 508767003351 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 508767003352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508767003353 non-specific DNA binding site [nucleotide binding]; other site 508767003354 salt bridge; other site 508767003355 sequence-specific DNA binding site [nucleotide binding]; other site 508767003356 Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742 508767003357 Clostridium neurotoxin, Translocation domain; Region: Toxin_trans; pfam07952 508767003358 Clostridium neurotoxin, N-terminal receptor binding; Region: Toxin_R_bind_N; pfam07953 508767003359 Clostridium neurotoxin, C-terminal receptor binding; Region: Toxin_R_bind_C; pfam07951 508767003360 Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742 508767003361 Clostridium neurotoxin, N-terminal receptor binding; Region: Toxin_R_bind_N; pfam07953 508767003362 Nontoxic nonhaemagglutinin C-terminal; Region: NTNH_C; pfam08470 508767003363 Clostridium P-47 protein; Region: Clostridium_P47; pfam06597 508767003364 Clostridium P-47 protein; Region: Clostridium_P47; pfam06597 508767003365 Clostridium P-47 protein; Region: Clostridium_P47; pfam06597 508767003366 recombination factor protein RarA; Reviewed; Region: PRK13342 508767003367 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 508767003368 Predicted transcriptional regulator [Transcription]; Region: COG1959 508767003369 Transcriptional regulator; Region: Rrf2; cl17282 508767003370 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 508767003371 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 508767003372 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508767003373 catalytic residue [active] 508767003374 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 508767003375 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 508767003376 trimerization site [polypeptide binding]; other site 508767003377 active site 508767003378 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 508767003379 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 508767003380 Ligand Binding Site [chemical binding]; other site 508767003381 PRC-barrel domain; Region: PRC; pfam05239 508767003382 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 508767003383 Domain of unknown function DUF20; Region: UPF0118; pfam01594 508767003384 T-box leader 508767003385 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 508767003386 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 508767003387 motif 1; other site 508767003388 active site 508767003389 motif 2; other site 508767003390 motif 3; other site 508767003391 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 508767003392 DHHA1 domain; Region: DHHA1; pfam02272 508767003393 hypothetical protein; Provisional; Region: PRK05473 508767003394 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 508767003395 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 508767003396 ferric uptake regulator; Provisional; Region: fur; PRK09462 508767003397 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 508767003398 metal binding site 2 [ion binding]; metal-binding site 508767003399 putative DNA binding helix; other site 508767003400 metal binding site 1 [ion binding]; metal-binding site 508767003401 dimer interface [polypeptide binding]; other site 508767003402 structural Zn2+ binding site [ion binding]; other site 508767003403 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 508767003404 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 508767003405 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 508767003406 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 508767003407 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 508767003408 G1 box; other site 508767003409 putative GEF interaction site [polypeptide binding]; other site 508767003410 GTP/Mg2+ binding site [chemical binding]; other site 508767003411 Switch I region; other site 508767003412 G2 box; other site 508767003413 G3 box; other site 508767003414 Switch II region; other site 508767003415 G4 box; other site 508767003416 G5 box; other site 508767003417 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 508767003418 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 508767003419 YceG-like family; Region: YceG; pfam02618 508767003420 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 508767003421 dimerization interface [polypeptide binding]; other site 508767003422 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 508767003423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767003424 S-adenosylmethionine binding site [chemical binding]; other site 508767003425 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 508767003426 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 508767003427 Peptidase family U32; Region: Peptidase_U32; pfam01136 508767003428 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 508767003429 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 508767003430 sporulation sigma factor SigK; Reviewed; Region: PRK05803 508767003431 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508767003432 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508767003433 DNA binding residues [nucleotide binding] 508767003434 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 508767003435 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 508767003436 Walker A motif; other site 508767003437 ATP binding site [chemical binding]; other site 508767003438 Walker B motif; other site 508767003439 cell division protein FtsA; Region: ftsA; TIGR01174 508767003440 Cell division protein FtsA; Region: FtsA; smart00842 508767003441 Cell division protein FtsA; Region: FtsA; pfam14450 508767003442 cell division protein FtsZ; Validated; Region: PRK09330 508767003443 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 508767003444 nucleotide binding site [chemical binding]; other site 508767003445 SulA interaction site; other site 508767003446 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 508767003447 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 508767003448 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 508767003449 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508767003450 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508767003451 DNA binding residues [nucleotide binding] 508767003452 sporulation sigma factor SigG; Reviewed; Region: PRK08215 508767003453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508767003454 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 508767003455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508767003456 DNA binding residues [nucleotide binding] 508767003457 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 508767003458 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 508767003459 ATP cone domain; Region: ATP-cone; pfam03477 508767003460 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 508767003461 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767003462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767003463 active site 508767003464 phosphorylation site [posttranslational modification] 508767003465 intermolecular recognition site; other site 508767003466 dimerization interface [polypeptide binding]; other site 508767003467 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767003468 DNA binding site [nucleotide binding] 508767003469 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767003470 dimerization interface [polypeptide binding]; other site 508767003471 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 508767003472 PAS domain; Region: PAS; smart00091 508767003473 putative active site [active] 508767003474 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767003475 dimer interface [polypeptide binding]; other site 508767003476 phosphorylation site [posttranslational modification] 508767003477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767003478 ATP binding site [chemical binding]; other site 508767003479 Mg2+ binding site [ion binding]; other site 508767003480 G-X-G motif; other site 508767003481 PBP superfamily domain; Region: PBP_like_2; cl17296 508767003482 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 508767003483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767003484 dimer interface [polypeptide binding]; other site 508767003485 conserved gate region; other site 508767003486 putative PBP binding loops; other site 508767003487 ABC-ATPase subunit interface; other site 508767003488 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 508767003489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767003490 dimer interface [polypeptide binding]; other site 508767003491 conserved gate region; other site 508767003492 putative PBP binding loops; other site 508767003493 ABC-ATPase subunit interface; other site 508767003494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 508767003495 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 508767003496 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 508767003497 Walker A/P-loop; other site 508767003498 ATP binding site [chemical binding]; other site 508767003499 Q-loop/lid; other site 508767003500 ABC transporter signature motif; other site 508767003501 Walker B; other site 508767003502 D-loop; other site 508767003503 H-loop/switch region; other site 508767003504 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 508767003505 PhoU domain; Region: PhoU; pfam01895 508767003506 PhoU domain; Region: PhoU; pfam01895 508767003507 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 508767003508 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 508767003509 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 508767003510 FeS/SAM binding site; other site 508767003511 Protein of unknown function (DUF512); Region: DUF512; pfam04459 508767003512 GTP-binding protein Der; Reviewed; Region: PRK00093 508767003513 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 508767003514 G1 box; other site 508767003515 GTP/Mg2+ binding site [chemical binding]; other site 508767003516 Switch I region; other site 508767003517 G2 box; other site 508767003518 Switch II region; other site 508767003519 G3 box; other site 508767003520 G4 box; other site 508767003521 G5 box; other site 508767003522 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 508767003523 G1 box; other site 508767003524 GTP/Mg2+ binding site [chemical binding]; other site 508767003525 Switch I region; other site 508767003526 G2 box; other site 508767003527 G3 box; other site 508767003528 Switch II region; other site 508767003529 G4 box; other site 508767003530 G5 box; other site 508767003531 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 508767003532 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 508767003533 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 508767003534 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 508767003535 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 508767003536 G1 box; other site 508767003537 GTP/Mg2+ binding site [chemical binding]; other site 508767003538 G2 box; other site 508767003539 Switch I region; other site 508767003540 G3 box; other site 508767003541 Switch II region; other site 508767003542 G4 box; other site 508767003543 G5 box; other site 508767003544 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 508767003545 active site 508767003546 homotetramer interface [polypeptide binding]; other site 508767003547 homodimer interface [polypeptide binding]; other site 508767003548 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 508767003549 hypothetical protein; Provisional; Region: PRK11820 508767003550 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 508767003551 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 508767003552 hypothetical protein; Provisional; Region: PRK04323 508767003553 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 508767003554 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 508767003555 catalytic site [active] 508767003556 G-X2-G-X-G-K; other site 508767003557 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 508767003558 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 508767003559 Flavoprotein; Region: Flavoprotein; pfam02441 508767003560 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 508767003561 primosome assembly protein PriA; Validated; Region: PRK05580 508767003562 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508767003563 ATP binding site [chemical binding]; other site 508767003564 putative Mg++ binding site [ion binding]; other site 508767003565 helicase superfamily c-terminal domain; Region: HELICc; smart00490 508767003566 ATP-binding site [chemical binding]; other site 508767003567 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 508767003568 active site 508767003569 catalytic residues [active] 508767003570 metal binding site [ion binding]; metal-binding site 508767003571 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 508767003572 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 508767003573 putative active site [active] 508767003574 substrate binding site [chemical binding]; other site 508767003575 putative cosubstrate binding site; other site 508767003576 catalytic site [active] 508767003577 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 508767003578 substrate binding site [chemical binding]; other site 508767003579 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 508767003580 16S rRNA methyltransferase B; Provisional; Region: PRK14902 508767003581 NusB family; Region: NusB; pfam01029 508767003582 putative RNA binding site [nucleotide binding]; other site 508767003583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767003584 S-adenosylmethionine binding site [chemical binding]; other site 508767003585 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 508767003586 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767003587 FeS/SAM binding site; other site 508767003588 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 508767003589 Protein phosphatase 2C; Region: PP2C; pfam00481 508767003590 active site 508767003591 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 508767003592 Catalytic domain of Protein Kinases; Region: PKc; cd00180 508767003593 active site 508767003594 ATP binding site [chemical binding]; other site 508767003595 substrate binding site [chemical binding]; other site 508767003596 activation loop (A-loop); other site 508767003597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 508767003598 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 508767003599 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 508767003600 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 508767003601 GTPase RsgA; Reviewed; Region: PRK00098 508767003602 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 508767003603 RNA binding site [nucleotide binding]; other site 508767003604 homodimer interface [polypeptide binding]; other site 508767003605 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 508767003606 GTPase/Zn-binding domain interface [polypeptide binding]; other site 508767003607 GTP/Mg2+ binding site [chemical binding]; other site 508767003608 G4 box; other site 508767003609 G5 box; other site 508767003610 G1 box; other site 508767003611 Switch I region; other site 508767003612 G2 box; other site 508767003613 G3 box; other site 508767003614 Switch II region; other site 508767003615 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 508767003616 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 508767003617 substrate binding site [chemical binding]; other site 508767003618 hexamer interface [polypeptide binding]; other site 508767003619 metal binding site [ion binding]; metal-binding site 508767003620 Thiamine pyrophosphokinase; Region: TPK; cd07995 508767003621 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 508767003622 active site 508767003623 dimerization interface [polypeptide binding]; other site 508767003624 thiamine binding site [chemical binding]; other site 508767003625 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 508767003626 Asp23 family; Region: Asp23; pfam03780 508767003627 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 508767003628 DAK2 domain; Region: Dak2; pfam02734 508767003629 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 508767003630 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508767003631 ATP binding site [chemical binding]; other site 508767003632 putative Mg++ binding site [ion binding]; other site 508767003633 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508767003634 nucleotide binding region [chemical binding]; other site 508767003635 ATP-binding site [chemical binding]; other site 508767003636 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 508767003637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767003638 S-adenosylmethionine binding site [chemical binding]; other site 508767003639 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 508767003640 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 508767003641 active site 508767003642 (T/H)XGH motif; other site 508767003643 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 508767003644 Nucleoside recognition; Region: Gate; pfam07670 508767003645 hypothetical protein; Provisional; Region: PRK13670 508767003646 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 508767003647 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 508767003648 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 508767003649 propionate/acetate kinase; Provisional; Region: PRK12379 508767003650 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 508767003651 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 508767003652 putative phosphate acyltransferase; Provisional; Region: PRK05331 508767003653 acyl carrier protein; Provisional; Region: acpP; PRK00982 508767003654 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 508767003655 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 508767003656 dimerization interface [polypeptide binding]; other site 508767003657 active site 508767003658 metal binding site [ion binding]; metal-binding site 508767003659 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 508767003660 dsRNA binding site [nucleotide binding]; other site 508767003661 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 508767003662 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767003663 FeS/SAM binding site; other site 508767003664 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 508767003665 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 508767003666 Walker A/P-loop; other site 508767003667 ATP binding site [chemical binding]; other site 508767003668 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 508767003669 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 508767003670 ABC transporter signature motif; other site 508767003671 Walker B; other site 508767003672 D-loop; other site 508767003673 H-loop/switch region; other site 508767003674 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 508767003675 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 508767003676 P loop; other site 508767003677 GTP binding site [chemical binding]; other site 508767003678 putative DNA-binding protein; Validated; Region: PRK00118 508767003679 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 508767003680 signal recognition particle protein; Provisional; Region: PRK10867 508767003681 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 508767003682 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 508767003683 P loop; other site 508767003684 GTP binding site [chemical binding]; other site 508767003685 Signal peptide binding domain; Region: SRP_SPB; pfam02978 508767003686 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 508767003687 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 508767003688 hypothetical protein; Provisional; Region: PRK00468 508767003689 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 508767003690 RimM N-terminal domain; Region: RimM; pfam01782 508767003691 PRC-barrel domain; Region: PRC; pfam05239 508767003692 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 508767003693 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 508767003694 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 508767003695 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 508767003696 GTP/Mg2+ binding site [chemical binding]; other site 508767003697 G4 box; other site 508767003698 G5 box; other site 508767003699 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 508767003700 G1 box; other site 508767003701 G1 box; other site 508767003702 GTP/Mg2+ binding site [chemical binding]; other site 508767003703 Switch I region; other site 508767003704 G2 box; other site 508767003705 G2 box; other site 508767003706 Switch I region; other site 508767003707 G3 box; other site 508767003708 G3 box; other site 508767003709 Switch II region; other site 508767003710 Switch II region; other site 508767003711 G4 box; other site 508767003712 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 508767003713 RNA/DNA hybrid binding site [nucleotide binding]; other site 508767003714 active site 508767003715 hypothetical protein; Reviewed; Region: PRK12497 508767003716 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 508767003717 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 508767003718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767003719 Walker A motif; other site 508767003720 ATP binding site [chemical binding]; other site 508767003721 Walker B motif; other site 508767003722 arginine finger; other site 508767003723 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 508767003724 DNA protecting protein DprA; Region: dprA; TIGR00732 508767003725 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 508767003726 DNA topoisomerase I; Validated; Region: PRK05582 508767003727 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 508767003728 active site 508767003729 interdomain interaction site; other site 508767003730 putative metal-binding site [ion binding]; other site 508767003731 nucleotide binding site [chemical binding]; other site 508767003732 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 508767003733 domain I; other site 508767003734 DNA binding groove [nucleotide binding] 508767003735 phosphate binding site [ion binding]; other site 508767003736 domain II; other site 508767003737 domain III; other site 508767003738 nucleotide binding site [chemical binding]; other site 508767003739 catalytic site [active] 508767003740 domain IV; other site 508767003741 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 508767003742 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 508767003743 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 508767003744 transcriptional repressor CodY; Validated; Region: PRK04158 508767003745 CodY GAF-like domain; Region: CodY; pfam06018 508767003746 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 508767003747 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 508767003748 rRNA interaction site [nucleotide binding]; other site 508767003749 S8 interaction site; other site 508767003750 putative laminin-1 binding site; other site 508767003751 elongation factor Ts; Provisional; Region: tsf; PRK09377 508767003752 UBA/TS-N domain; Region: UBA; pfam00627 508767003753 Elongation factor TS; Region: EF_TS; pfam00889 508767003754 Elongation factor TS; Region: EF_TS; pfam00889 508767003755 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 508767003756 putative nucleotide binding site [chemical binding]; other site 508767003757 uridine monophosphate binding site [chemical binding]; other site 508767003758 homohexameric interface [polypeptide binding]; other site 508767003759 ribosome recycling factor; Reviewed; Region: frr; PRK00083 508767003760 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 508767003761 hinge region; other site 508767003762 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 508767003763 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 508767003764 catalytic residue [active] 508767003765 putative FPP diphosphate binding site; other site 508767003766 putative FPP binding hydrophobic cleft; other site 508767003767 dimer interface [polypeptide binding]; other site 508767003768 putative IPP diphosphate binding site; other site 508767003769 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 508767003770 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 508767003771 Domain of unknown function DUF20; Region: UPF0118; pfam01594 508767003772 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 508767003773 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 508767003774 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 508767003775 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 508767003776 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 508767003777 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 508767003778 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 508767003779 active site 508767003780 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 508767003781 protein binding site [polypeptide binding]; other site 508767003782 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 508767003783 putative substrate binding region [chemical binding]; other site 508767003784 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 508767003785 GcpE protein; Region: GcpE; pfam04551 508767003786 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 508767003787 DNA polymerase III PolC; Validated; Region: polC; PRK00448 508767003788 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 508767003789 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 508767003790 generic binding surface II; other site 508767003791 generic binding surface I; other site 508767003792 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 508767003793 active site 508767003794 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 508767003795 active site 508767003796 catalytic site [active] 508767003797 substrate binding site [chemical binding]; other site 508767003798 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 508767003799 ribosome maturation protein RimP; Reviewed; Region: PRK00092 508767003800 Sm and related proteins; Region: Sm_like; cl00259 508767003801 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 508767003802 putative oligomer interface [polypeptide binding]; other site 508767003803 putative RNA binding site [nucleotide binding]; other site 508767003804 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 508767003805 NusA N-terminal domain; Region: NusA_N; pfam08529 508767003806 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 508767003807 RNA binding site [nucleotide binding]; other site 508767003808 homodimer interface [polypeptide binding]; other site 508767003809 NusA-like KH domain; Region: KH_5; pfam13184 508767003810 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 508767003811 G-X-X-G motif; other site 508767003812 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 508767003813 putative RNA binding cleft [nucleotide binding]; other site 508767003814 ribosomal protein L7Ae family protein; Provisional; Region: PRK05583 508767003815 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 508767003816 translation initiation factor IF-2; Region: IF-2; TIGR00487 508767003817 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 508767003818 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 508767003819 G1 box; other site 508767003820 putative GEF interaction site [polypeptide binding]; other site 508767003821 GTP/Mg2+ binding site [chemical binding]; other site 508767003822 Switch I region; other site 508767003823 G2 box; other site 508767003824 G3 box; other site 508767003825 Switch II region; other site 508767003826 G4 box; other site 508767003827 G5 box; other site 508767003828 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 508767003829 Translation-initiation factor 2; Region: IF-2; pfam11987 508767003830 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 508767003831 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 508767003832 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 508767003833 DHH family; Region: DHH; pfam01368 508767003834 DHHA1 domain; Region: DHHA1; pfam02272 508767003835 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 508767003836 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 508767003837 RNA binding site [nucleotide binding]; other site 508767003838 active site 508767003839 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 508767003840 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 508767003841 active site 508767003842 Riboflavin kinase; Region: Flavokinase; pfam01687 508767003843 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 508767003844 16S/18S rRNA binding site [nucleotide binding]; other site 508767003845 S13e-L30e interaction site [polypeptide binding]; other site 508767003846 25S rRNA binding site [nucleotide binding]; other site 508767003847 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 508767003848 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 508767003849 RNase E interface [polypeptide binding]; other site 508767003850 trimer interface [polypeptide binding]; other site 508767003851 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 508767003852 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 508767003853 RNase E interface [polypeptide binding]; other site 508767003854 trimer interface [polypeptide binding]; other site 508767003855 active site 508767003856 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 508767003857 putative nucleic acid binding region [nucleotide binding]; other site 508767003858 G-X-X-G motif; other site 508767003859 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 508767003860 RNA binding site [nucleotide binding]; other site 508767003861 domain interface; other site 508767003862 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 508767003863 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 508767003864 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 508767003865 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 508767003866 aspartate kinase I; Reviewed; Region: PRK08210 508767003867 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 508767003868 nucleotide binding site [chemical binding]; other site 508767003869 substrate binding site [chemical binding]; other site 508767003870 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 508767003871 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 508767003872 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 508767003873 Clp protease; Region: CLP_protease; pfam00574 508767003874 active site 508767003875 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 508767003876 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 508767003877 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 508767003878 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 508767003879 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 508767003880 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 508767003881 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767003882 FeS/SAM binding site; other site 508767003883 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 508767003884 recombinase A; Provisional; Region: recA; PRK09354 508767003885 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 508767003886 hexamer interface [polypeptide binding]; other site 508767003887 Walker A motif; other site 508767003888 ATP binding site [chemical binding]; other site 508767003889 Walker B motif; other site 508767003890 phosphodiesterase; Provisional; Region: PRK12704 508767003891 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 508767003892 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508767003893 Zn2+ binding site [ion binding]; other site 508767003894 Mg2+ binding site [ion binding]; other site 508767003895 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 508767003896 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 508767003897 dimerization domain swap beta strand [polypeptide binding]; other site 508767003898 regulatory protein interface [polypeptide binding]; other site 508767003899 active site 508767003900 regulatory phosphorylation site [posttranslational modification]; other site 508767003901 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 508767003902 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 508767003903 tetramer interface [polypeptide binding]; other site 508767003904 active site 508767003905 Putative amidase domain; Region: Amidase_6; pfam12671 508767003906 Suppression of tumorigenicity 7; Region: ST7; cd11557 508767003907 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 508767003908 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 508767003909 catalytic motif [active] 508767003910 Zn binding site [ion binding]; other site 508767003911 RibD C-terminal domain; Region: RibD_C; cl17279 508767003912 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 508767003913 Lumazine binding domain; Region: Lum_binding; pfam00677 508767003914 Lumazine binding domain; Region: Lum_binding; pfam00677 508767003915 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 508767003916 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 508767003917 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 508767003918 dimerization interface [polypeptide binding]; other site 508767003919 active site 508767003920 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 508767003921 homopentamer interface [polypeptide binding]; other site 508767003922 active site 508767003923 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 508767003924 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 508767003925 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 508767003926 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508767003927 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 508767003928 putative active site [active] 508767003929 metal binding site [ion binding]; metal-binding site 508767003930 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 508767003931 intersubunit interface [polypeptide binding]; other site 508767003932 active site 508767003933 zinc binding site [ion binding]; other site 508767003934 Na+ binding site [ion binding]; other site 508767003935 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 508767003936 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 508767003937 substrate binding site [chemical binding]; other site 508767003938 ATP binding site [chemical binding]; other site 508767003939 KduI/IolB family; Region: KduI; pfam04962 508767003940 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 508767003941 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 508767003942 PYR/PP interface [polypeptide binding]; other site 508767003943 dimer interface [polypeptide binding]; other site 508767003944 TPP binding site [chemical binding]; other site 508767003945 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 508767003946 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 508767003947 TPP-binding site; other site 508767003948 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 508767003949 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 508767003950 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 508767003951 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 508767003952 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 508767003953 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 508767003954 putative transporter; Provisional; Region: PRK10484 508767003955 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 508767003956 Na binding site [ion binding]; other site 508767003957 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 508767003958 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 508767003959 active site 508767003960 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 508767003961 dimer interface [polypeptide binding]; other site 508767003962 ADP-ribose binding site [chemical binding]; other site 508767003963 active site 508767003964 nudix motif; other site 508767003965 metal binding site [ion binding]; metal-binding site 508767003966 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 508767003967 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 508767003968 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 508767003969 putative Cl- selectivity filter; other site 508767003970 putative pore gating glutamate residue; other site 508767003971 T-box leader 508767003972 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 508767003973 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 508767003974 putative active site [active] 508767003975 metal binding site [ion binding]; metal-binding site 508767003976 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767003977 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 508767003978 2-isopropylmalate synthase; Validated; Region: PRK03739 508767003979 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 508767003980 active site 508767003981 catalytic residues [active] 508767003982 metal binding site [ion binding]; metal-binding site 508767003983 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 508767003984 phosphodiesterase YaeI; Provisional; Region: PRK11340 508767003985 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 508767003986 putative active site [active] 508767003987 putative metal binding site [ion binding]; other site 508767003988 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 508767003989 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767003990 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 508767003991 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 508767003992 putative oligomer interface [polypeptide binding]; other site 508767003993 putative active site [active] 508767003994 metal binding site [ion binding]; metal-binding site 508767003995 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 508767003996 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508767003997 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140 508767003998 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 508767003999 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 508767004000 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 508767004001 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 508767004002 Predicted permease; Region: DUF318; cl17795 508767004003 Hemerythrin; Region: Hemerythrin; cd12107 508767004004 Fe binding site [ion binding]; other site 508767004005 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 508767004006 EamA-like transporter family; Region: EamA; pfam00892 508767004007 EamA-like transporter family; Region: EamA; pfam00892 508767004008 helicase 45; Provisional; Region: PTZ00424 508767004009 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 508767004010 ATP binding site [chemical binding]; other site 508767004011 putative Mg++ binding site [ion binding]; other site 508767004012 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508767004013 nucleotide binding region [chemical binding]; other site 508767004014 ATP-binding site [chemical binding]; other site 508767004015 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 508767004016 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 508767004017 ATP binding site [chemical binding]; other site 508767004018 Mg++ binding site [ion binding]; other site 508767004019 motif III; other site 508767004020 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508767004021 nucleotide binding region [chemical binding]; other site 508767004022 ATP-binding site [chemical binding]; other site 508767004023 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 508767004024 RNA binding site [nucleotide binding]; other site 508767004025 methionine aminopeptidase; Provisional; Region: PRK12318 508767004026 SEC-C motif; Region: SEC-C; pfam02810 508767004027 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 508767004028 active site 508767004029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767004030 AAA domain; Region: AAA_23; pfam13476 508767004031 Walker A/P-loop; other site 508767004032 ATP binding site [chemical binding]; other site 508767004033 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 508767004034 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 508767004035 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 508767004036 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 508767004037 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 508767004038 DNA binding residues [nucleotide binding] 508767004039 drug binding residues [chemical binding]; other site 508767004040 dimer interface [polypeptide binding]; other site 508767004041 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 508767004042 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 508767004043 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 508767004044 inhibitor binding site; inhibition site 508767004045 Active site flap [active] 508767004046 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 508767004047 Ligand binding site [chemical binding]; other site 508767004048 Electron transfer flavoprotein domain; Region: ETF; pfam01012 508767004049 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 508767004050 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 508767004051 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 508767004052 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 508767004053 L-lactate permease; Region: Lactate_perm; cl00701 508767004054 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 508767004055 FAD binding domain; Region: FAD_binding_4; pfam01565 508767004056 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 508767004057 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 508767004058 FAD binding site [chemical binding]; other site 508767004059 homotetramer interface [polypeptide binding]; other site 508767004060 substrate binding pocket [chemical binding]; other site 508767004061 catalytic base [active] 508767004062 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 508767004063 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767004064 Walker A/P-loop; other site 508767004065 ATP binding site [chemical binding]; other site 508767004066 Q-loop/lid; other site 508767004067 ABC transporter signature motif; other site 508767004068 Walker B; other site 508767004069 D-loop; other site 508767004070 H-loop/switch region; other site 508767004071 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508767004072 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 508767004073 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 508767004074 dimer interface [polypeptide binding]; other site 508767004075 active site 508767004076 heme binding site [chemical binding]; other site 508767004077 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 508767004078 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 508767004079 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 508767004080 active pocket/dimerization site; other site 508767004081 active site 508767004082 phosphorylation site [posttranslational modification] 508767004083 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 508767004084 active site 508767004085 phosphorylation site [posttranslational modification] 508767004086 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 508767004087 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 508767004088 Domain of unknown function (DUF956); Region: DUF956; pfam06115 508767004089 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 508767004090 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 508767004091 substrate binding pocket [chemical binding]; other site 508767004092 membrane-bound complex binding site; other site 508767004093 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 508767004094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767004095 dimer interface [polypeptide binding]; other site 508767004096 conserved gate region; other site 508767004097 putative PBP binding loops; other site 508767004098 ABC-ATPase subunit interface; other site 508767004099 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 508767004100 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767004101 Walker A/P-loop; other site 508767004102 ATP binding site [chemical binding]; other site 508767004103 Q-loop/lid; other site 508767004104 ABC transporter signature motif; other site 508767004105 Walker B; other site 508767004106 D-loop; other site 508767004107 H-loop/switch region; other site 508767004108 TOBE domain; Region: TOBE; cl01440 508767004109 Domain of unknown function (DUF364); Region: DUF364; pfam04016 508767004110 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 508767004111 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 508767004112 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 508767004113 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 508767004114 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 508767004115 active site 508767004116 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 508767004117 asparagine synthetase B; Provisional; Region: asnB; PRK09431 508767004118 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 508767004119 dimer interface [polypeptide binding]; other site 508767004120 active site 508767004121 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 508767004122 Ligand Binding Site [chemical binding]; other site 508767004123 Molecular Tunnel; other site 508767004124 T-box leader 508767004125 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 508767004126 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 508767004127 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 508767004128 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 508767004129 TrkA-C domain; Region: TrkA_C; pfam02080 508767004130 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 508767004131 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508767004132 MarR family; Region: MarR_2; pfam12802 508767004133 putative transporter; Provisional; Region: PRK10504 508767004134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508767004135 putative substrate translocation pore; other site 508767004136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508767004137 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 508767004138 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 508767004139 FMN binding site [chemical binding]; other site 508767004140 active site 508767004141 catalytic residues [active] 508767004142 substrate binding site [chemical binding]; other site 508767004143 Uncharacterized conserved protein [Function unknown]; Region: COG0397 508767004144 hypothetical protein; Validated; Region: PRK00029 508767004145 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 508767004146 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491 508767004147 Putative transcription activator [Transcription]; Region: TenA; COG0819 508767004148 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 508767004149 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 508767004150 HSP70 interaction site [polypeptide binding]; other site 508767004151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508767004152 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508767004153 putative substrate translocation pore; other site 508767004154 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508767004155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508767004156 putative substrate translocation pore; other site 508767004157 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 508767004158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767004159 Walker A/P-loop; other site 508767004160 ATP binding site [chemical binding]; other site 508767004161 Q-loop/lid; other site 508767004162 ABC transporter signature motif; other site 508767004163 Walker B; other site 508767004164 D-loop; other site 508767004165 H-loop/switch region; other site 508767004166 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 508767004167 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508767004168 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767004169 active site 508767004170 motif I; other site 508767004171 motif II; other site 508767004172 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 508767004173 ykoK leader; ykoK element 508767004174 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 508767004175 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 508767004176 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508767004177 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 508767004178 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 508767004179 Soluble P-type ATPase [General function prediction only]; Region: COG4087 508767004180 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 508767004181 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 508767004182 jmjN domain; Region: JmjN; cl15840 508767004183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767004184 S-adenosylmethionine binding site [chemical binding]; other site 508767004185 xanthine permease; Region: pbuX; TIGR03173 508767004186 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 508767004187 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 508767004188 FAD binding site [chemical binding]; other site 508767004189 homotetramer interface [polypeptide binding]; other site 508767004190 substrate binding pocket [chemical binding]; other site 508767004191 catalytic base [active] 508767004192 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 508767004193 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 508767004194 Rubredoxin [Energy production and conversion]; Region: COG1773 508767004195 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 508767004196 iron binding site [ion binding]; other site 508767004197 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 508767004198 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 508767004199 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 508767004200 Accessory gene regulator B; Region: AgrB; pfam04647 508767004201 Staphylococcal AgrD protein; Region: AgrD; cl05477 508767004202 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 508767004203 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508767004204 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508767004205 metal binding site [ion binding]; metal-binding site 508767004206 active site 508767004207 I-site; other site 508767004208 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 508767004209 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508767004210 Zn2+ binding site [ion binding]; other site 508767004211 Mg2+ binding site [ion binding]; other site 508767004212 inner membrane transporter YjeM; Provisional; Region: PRK15238 508767004213 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 508767004214 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 508767004215 DNA binding residues [nucleotide binding] 508767004216 putative dimer interface [polypeptide binding]; other site 508767004217 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 508767004218 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 508767004219 TPP-binding site; other site 508767004220 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 508767004221 PYR/PP interface [polypeptide binding]; other site 508767004222 dimer interface [polypeptide binding]; other site 508767004223 TPP binding site [chemical binding]; other site 508767004224 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 508767004225 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767004226 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508767004227 active site 508767004228 motif I; other site 508767004229 motif II; other site 508767004230 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 508767004231 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 508767004232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767004233 Walker A motif; other site 508767004234 ATP binding site [chemical binding]; other site 508767004235 Walker B motif; other site 508767004236 arginine finger; other site 508767004237 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 508767004238 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 508767004239 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 508767004240 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 508767004241 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 508767004242 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 508767004243 Coenzyme A transferase; Region: CoA_trans; smart00882 508767004244 Coenzyme A transferase; Region: CoA_trans; cl17247 508767004245 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 508767004246 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 508767004247 metal binding site [ion binding]; metal-binding site 508767004248 dimer interface [polypeptide binding]; other site 508767004249 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 508767004250 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 508767004251 active site 508767004252 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508767004253 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 508767004254 putative active site [active] 508767004255 metal binding site [ion binding]; metal-binding site 508767004256 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 508767004257 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 508767004258 DNA binding residues [nucleotide binding] 508767004259 drug binding residues [chemical binding]; other site 508767004260 dimer interface [polypeptide binding]; other site 508767004261 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 508767004262 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 508767004263 Transcriptional regulator PadR-like family; Region: PadR; cl17335 508767004264 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 508767004265 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 508767004266 Hexamer interface [polypeptide binding]; other site 508767004267 Hexagonal pore residue; other site 508767004268 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 508767004269 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 508767004270 Hexamer interface [polypeptide binding]; other site 508767004271 Hexagonal pore residue; other site 508767004272 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 508767004273 putative catalytic cysteine [active] 508767004274 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 508767004275 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 508767004276 dimer interface [polypeptide binding]; other site 508767004277 active site 508767004278 glycine loop; other site 508767004279 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 508767004280 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 508767004281 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 508767004282 putative hexamer interface [polypeptide binding]; other site 508767004283 putative hexagonal pore; other site 508767004284 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 508767004285 G1 box; other site 508767004286 GTP/Mg2+ binding site [chemical binding]; other site 508767004287 G2 box; other site 508767004288 Switch I region; other site 508767004289 G3 box; other site 508767004290 Switch II region; other site 508767004291 G4 box; other site 508767004292 G5 box; other site 508767004293 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 508767004294 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 508767004295 Cell division protein FtsA; Region: FtsA; cl17206 508767004296 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 508767004297 nucleotide binding site [chemical binding]; other site 508767004298 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 508767004299 Hexamer interface [polypeptide binding]; other site 508767004300 Hexagonal pore residue; other site 508767004301 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 508767004302 Hexamer/Pentamer interface [polypeptide binding]; other site 508767004303 central pore; other site 508767004304 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 508767004305 SLBB domain; Region: SLBB; pfam10531 508767004306 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 508767004307 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 508767004308 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 508767004309 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 508767004310 putative hexamer interface [polypeptide binding]; other site 508767004311 putative hexagonal pore; other site 508767004312 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 508767004313 putative hexamer interface [polypeptide binding]; other site 508767004314 putative hexagonal pore; other site 508767004315 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 508767004316 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 508767004317 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 508767004318 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 508767004319 Hexamer interface [polypeptide binding]; other site 508767004320 Hexagonal pore residue; other site 508767004321 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 508767004322 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 508767004323 putative catalytic cysteine [active] 508767004324 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 508767004325 Propanediol utilisation protein PduL; Region: PduL; pfam06130 508767004326 Ubiquitin-like proteins; Region: UBQ; cl00155 508767004327 charged pocket; other site 508767004328 Propanediol utilisation protein PduL; Region: PduL; pfam06130 508767004329 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 508767004330 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 508767004331 Hexamer interface [polypeptide binding]; other site 508767004332 Putative hexagonal pore residue; other site 508767004333 Hemerythrin; Region: Hemerythrin; cd12107 508767004334 Fe binding site [ion binding]; other site 508767004335 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 508767004336 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 508767004337 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 508767004338 intersubunit interface [polypeptide binding]; other site 508767004339 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 508767004340 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508767004341 ABC-ATPase subunit interface; other site 508767004342 dimer interface [polypeptide binding]; other site 508767004343 putative PBP binding regions; other site 508767004344 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 508767004345 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 508767004346 Walker A/P-loop; other site 508767004347 ATP binding site [chemical binding]; other site 508767004348 Q-loop/lid; other site 508767004349 ABC transporter signature motif; other site 508767004350 Walker B; other site 508767004351 D-loop; other site 508767004352 H-loop/switch region; other site 508767004353 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 508767004354 DEAD-like helicases superfamily; Region: DEXDc; smart00487 508767004355 ATP binding site [chemical binding]; other site 508767004356 Mg++ binding site [ion binding]; other site 508767004357 motif III; other site 508767004358 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508767004359 nucleotide binding region [chemical binding]; other site 508767004360 ATP-binding site [chemical binding]; other site 508767004361 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508767004362 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 508767004363 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 508767004364 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 508767004365 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 508767004366 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 508767004367 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 508767004368 Acyltransferase family; Region: Acyl_transf_3; pfam01757 508767004369 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 508767004370 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 508767004371 putative RNA binding site [nucleotide binding]; other site 508767004372 Methyltransferase domain; Region: Methyltransf_26; pfam13659 508767004373 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 508767004374 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508767004375 Domain of unknown function DUF77; Region: DUF77; pfam01910 508767004376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767004377 Response regulator receiver domain; Region: Response_reg; pfam00072 508767004378 active site 508767004379 phosphorylation site [posttranslational modification] 508767004380 intermolecular recognition site; other site 508767004381 dimerization interface [polypeptide binding]; other site 508767004382 PAS fold; Region: PAS_4; pfam08448 508767004383 PAS fold; Region: PAS_4; pfam08448 508767004384 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508767004385 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508767004386 metal binding site [ion binding]; metal-binding site 508767004387 active site 508767004388 I-site; other site 508767004389 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 508767004390 TraX protein; Region: TraX; cl05434 508767004391 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 508767004392 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 508767004393 metal binding triad [ion binding]; metal-binding site 508767004394 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 508767004395 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 508767004396 NAD binding site [chemical binding]; other site 508767004397 sugar binding site [chemical binding]; other site 508767004398 divalent metal binding site [ion binding]; other site 508767004399 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508767004400 dimer interface [polypeptide binding]; other site 508767004401 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 508767004402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767004403 Walker A motif; other site 508767004404 ATP binding site [chemical binding]; other site 508767004405 Walker B motif; other site 508767004406 arginine finger; other site 508767004407 Transcriptional antiterminator [Transcription]; Region: COG3933 508767004408 PRD domain; Region: PRD; pfam00874 508767004409 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 508767004410 active pocket/dimerization site; other site 508767004411 active site 508767004412 phosphorylation site [posttranslational modification] 508767004413 PRD domain; Region: PRD; pfam00874 508767004414 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 508767004415 active site 508767004416 P-loop; other site 508767004417 phosphorylation site [posttranslational modification] 508767004418 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 508767004419 methionine cluster; other site 508767004420 active site 508767004421 phosphorylation site [posttranslational modification] 508767004422 metal binding site [ion binding]; metal-binding site 508767004423 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 508767004424 nucleotide binding site [chemical binding]; other site 508767004425 Uncharacterized conserved protein [Function unknown]; Region: COG3589 508767004426 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 508767004427 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 508767004428 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 508767004429 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508767004430 Uncharacterized conserved protein [Function unknown]; Region: COG1284 508767004431 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508767004432 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 508767004433 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767004434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767004435 active site 508767004436 phosphorylation site [posttranslational modification] 508767004437 intermolecular recognition site; other site 508767004438 dimerization interface [polypeptide binding]; other site 508767004439 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767004440 DNA binding site [nucleotide binding] 508767004441 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767004442 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767004443 dimerization interface [polypeptide binding]; other site 508767004444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767004445 dimer interface [polypeptide binding]; other site 508767004446 phosphorylation site [posttranslational modification] 508767004447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767004448 ATP binding site [chemical binding]; other site 508767004449 Mg2+ binding site [ion binding]; other site 508767004450 G-X-G motif; other site 508767004451 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238 508767004452 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 508767004453 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 508767004454 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 508767004455 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508767004456 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 508767004457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767004458 motif II; other site 508767004459 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 508767004460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767004461 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 508767004462 Coenzyme A binding pocket [chemical binding]; other site 508767004463 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 508767004464 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 508767004465 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 508767004466 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508767004467 active site turn [active] 508767004468 phosphorylation site [posttranslational modification] 508767004469 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 508767004470 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 508767004471 HPr interaction site; other site 508767004472 glycerol kinase (GK) interaction site [polypeptide binding]; other site 508767004473 active site 508767004474 phosphorylation site [posttranslational modification] 508767004475 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 508767004476 beta-galactosidase; Region: BGL; TIGR03356 508767004477 transcriptional antiterminator BglG; Provisional; Region: PRK09772 508767004478 CAT RNA binding domain; Region: CAT_RBD; smart01061 508767004479 PRD domain; Region: PRD; pfam00874 508767004480 PRD domain; Region: PRD; pfam00874 508767004481 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 508767004482 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 508767004483 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 508767004484 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508767004485 DNA binding residues [nucleotide binding] 508767004486 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 508767004487 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 508767004488 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767004489 dimer interface [polypeptide binding]; other site 508767004490 putative CheW interface [polypeptide binding]; other site 508767004491 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 508767004492 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 508767004493 NodB motif; other site 508767004494 active site 508767004495 catalytic site [active] 508767004496 Zn binding site [ion binding]; other site 508767004497 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 508767004498 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 508767004499 substrate binding site [chemical binding]; other site 508767004500 dimer interface [polypeptide binding]; other site 508767004501 ATP binding site [chemical binding]; other site 508767004502 D-ribose pyranase; Provisional; Region: PRK11797 508767004503 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 508767004504 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 508767004505 Walker A/P-loop; other site 508767004506 ATP binding site [chemical binding]; other site 508767004507 Q-loop/lid; other site 508767004508 ABC transporter signature motif; other site 508767004509 Walker B; other site 508767004510 D-loop; other site 508767004511 H-loop/switch region; other site 508767004512 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 508767004513 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 508767004514 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 508767004515 TM-ABC transporter signature motif; other site 508767004516 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 508767004517 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 508767004518 ligand binding site [chemical binding]; other site 508767004519 dimerization interface [polypeptide binding]; other site 508767004520 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508767004521 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508767004522 DNA binding site [nucleotide binding] 508767004523 domain linker motif; other site 508767004524 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 508767004525 dimerization interface [polypeptide binding]; other site 508767004526 ligand binding site [chemical binding]; other site 508767004527 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 508767004528 putative active site pocket [active] 508767004529 dimerization interface [polypeptide binding]; other site 508767004530 putative catalytic residue [active] 508767004531 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 508767004532 putative substrate binding pocket [chemical binding]; other site 508767004533 AC domain interface; other site 508767004534 catalytic triad [active] 508767004535 AB domain interface; other site 508767004536 interchain disulfide; other site 508767004537 Predicted membrane protein [Function unknown]; Region: COG3817 508767004538 Protein of unknown function (DUF979); Region: DUF979; pfam06166 508767004539 Protein of unknown function (DUF969); Region: DUF969; pfam06149 508767004540 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 508767004541 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 508767004542 NAD binding site [chemical binding]; other site 508767004543 substrate binding site [chemical binding]; other site 508767004544 active site 508767004545 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 508767004546 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 508767004547 inhibitor-cofactor binding pocket; inhibition site 508767004548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767004549 catalytic residue [active] 508767004550 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 508767004551 ligand binding site; other site 508767004552 tetramer interface; other site 508767004553 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 508767004554 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 508767004555 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 508767004556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 508767004557 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 508767004558 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 508767004559 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 508767004560 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 508767004561 Substrate binding site; other site 508767004562 metal-binding site 508767004563 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508767004564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767004565 Coenzyme A binding pocket [chemical binding]; other site 508767004566 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 508767004567 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 508767004568 active site 508767004569 homodimer interface [polypeptide binding]; other site 508767004570 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 508767004571 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 508767004572 A-macroglobulin receptor; Region: A2M_recep; pfam07677 508767004573 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 508767004574 NeuB family; Region: NeuB; pfam03102 508767004575 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 508767004576 NeuB binding interface [polypeptide binding]; other site 508767004577 putative substrate binding site [chemical binding]; other site 508767004578 Protein of unknown function, DUF606; Region: DUF606; pfam04657 508767004579 Protein of unknown function, DUF606; Region: DUF606; pfam04657 508767004580 Membrane protein of unknown function; Region: DUF360; pfam04020 508767004581 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 508767004582 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508767004583 ligand binding site [chemical binding]; other site 508767004584 flexible hinge region; other site 508767004585 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 508767004586 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 508767004587 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 508767004588 yybP-ykoY leader 508767004589 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 508767004590 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767004591 FeS/SAM binding site; other site 508767004592 Uncharacterized conserved protein [Function unknown]; Region: COG1359 508767004593 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 508767004594 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 508767004595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767004596 active site 508767004597 phosphorylation site [posttranslational modification] 508767004598 intermolecular recognition site; other site 508767004599 dimerization interface [polypeptide binding]; other site 508767004600 Methyltransferase domain; Region: Methyltransf_31; pfam13847 508767004601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767004602 S-adenosylmethionine binding site [chemical binding]; other site 508767004603 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 508767004604 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508767004605 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 508767004606 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 508767004607 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 508767004608 synthetase active site [active] 508767004609 NTP binding site [chemical binding]; other site 508767004610 metal binding site [ion binding]; metal-binding site 508767004611 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 508767004612 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508767004613 Zn2+ binding site [ion binding]; other site 508767004614 Mg2+ binding site [ion binding]; other site 508767004615 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 508767004616 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 508767004617 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 508767004618 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 508767004619 dimer interface [polypeptide binding]; other site 508767004620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767004621 catalytic residue [active] 508767004622 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508767004623 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508767004624 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 508767004625 alanine racemase; Reviewed; Region: alr; PRK00053 508767004626 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 508767004627 active site 508767004628 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 508767004629 dimer interface [polypeptide binding]; other site 508767004630 substrate binding site [chemical binding]; other site 508767004631 catalytic residues [active] 508767004632 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 508767004633 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508767004634 DNA-binding site [nucleotide binding]; DNA binding site 508767004635 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508767004636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767004637 homodimer interface [polypeptide binding]; other site 508767004638 catalytic residue [active] 508767004639 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508767004640 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508767004641 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 508767004642 Protein of unknown function (DUF503); Region: DUF503; pfam04456 508767004643 Predicted membrane protein [Function unknown]; Region: COG4129 508767004644 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 508767004645 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 508767004646 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 508767004647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508767004648 DNA-binding site [nucleotide binding]; DNA binding site 508767004649 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 508767004650 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 508767004651 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 508767004652 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 508767004653 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 508767004654 phosphopentomutase; Provisional; Region: PRK05362 508767004655 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 508767004656 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 508767004657 transketolase; Reviewed; Region: PRK05899 508767004658 TPP-binding site [chemical binding]; other site 508767004659 dimer interface [polypeptide binding]; other site 508767004660 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 508767004661 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 508767004662 PYR/PP interface [polypeptide binding]; other site 508767004663 dimer interface [polypeptide binding]; other site 508767004664 TPP binding site [chemical binding]; other site 508767004665 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 508767004666 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 508767004667 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 508767004668 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 508767004669 active site 508767004670 intersubunit interactions; other site 508767004671 catalytic residue [active] 508767004672 Predicted membrane protein [Function unknown]; Region: COG1511 508767004673 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 508767004674 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 508767004675 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 508767004676 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508767004677 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 508767004678 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 508767004679 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 508767004680 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 508767004681 Dynamin family; Region: Dynamin_N; pfam00350 508767004682 G1 box; other site 508767004683 GTP/Mg2+ binding site [chemical binding]; other site 508767004684 G2 box; other site 508767004685 Switch I region; other site 508767004686 G3 box; other site 508767004687 Switch II region; other site 508767004688 G4 box; other site 508767004689 G5 box; other site 508767004690 Dynamin family; Region: Dynamin_N; pfam00350 508767004691 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 508767004692 GTP/Mg2+ binding site [chemical binding]; other site 508767004693 G1 box; other site 508767004694 G2 box; other site 508767004695 Switch I region; other site 508767004696 G3 box; other site 508767004697 Switch II region; other site 508767004698 G4 box; other site 508767004699 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 508767004700 G1 box; other site 508767004701 GTP/Mg2+ binding site [chemical binding]; other site 508767004702 G2 box; other site 508767004703 Switch I region; other site 508767004704 G3 box; other site 508767004705 Switch II region; other site 508767004706 G4 box; other site 508767004707 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 508767004708 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 508767004709 inhibitor-cofactor binding pocket; inhibition site 508767004710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767004711 catalytic residue [active] 508767004712 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 508767004713 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 508767004714 DNA binding residues [nucleotide binding] 508767004715 dimer interface [polypeptide binding]; other site 508767004716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767004717 S-adenosylmethionine binding site [chemical binding]; other site 508767004718 Isochorismatase family; Region: Isochorismatase; pfam00857 508767004719 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 508767004720 catalytic triad [active] 508767004721 conserved cis-peptide bond; other site 508767004722 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 508767004723 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508767004724 active site 508767004725 catalytic triad [active] 508767004726 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508767004727 active site 508767004728 catalytic triad [active] 508767004729 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 508767004730 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 508767004731 NAD(P) binding site [chemical binding]; other site 508767004732 catalytic residues [active] 508767004733 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508767004734 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140 508767004735 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 508767004736 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 508767004737 ATP-grasp domain; Region: ATP-grasp_4; cl17255 508767004738 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 508767004739 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 508767004740 nudix motif; other site 508767004741 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144 508767004742 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508767004743 Predicted transcriptional regulators [Transcription]; Region: COG1725 508767004744 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508767004745 DNA-binding site [nucleotide binding]; DNA binding site 508767004746 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 508767004747 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 508767004748 Walker A/P-loop; other site 508767004749 ATP binding site [chemical binding]; other site 508767004750 Q-loop/lid; other site 508767004751 ABC transporter signature motif; other site 508767004752 Walker B; other site 508767004753 D-loop; other site 508767004754 H-loop/switch region; other site 508767004755 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 508767004756 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508767004757 RNA binding surface [nucleotide binding]; other site 508767004758 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 508767004759 active site 508767004760 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 508767004761 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 508767004762 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 508767004763 putative active site [active] 508767004764 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 508767004765 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 508767004766 active site 508767004767 NTP binding site [chemical binding]; other site 508767004768 metal binding triad [ion binding]; metal-binding site 508767004769 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 508767004770 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 508767004771 Late competence development protein ComFB; Region: ComFB; pfam10719 508767004772 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 508767004773 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 508767004774 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 508767004775 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 508767004776 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767004777 FeS/SAM binding site; other site 508767004778 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 508767004779 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 508767004780 DNA topoisomerase III; Provisional; Region: PRK07726 508767004781 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 508767004782 active site 508767004783 putative interdomain interaction site [polypeptide binding]; other site 508767004784 putative metal-binding site [ion binding]; other site 508767004785 putative nucleotide binding site [chemical binding]; other site 508767004786 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 508767004787 domain I; other site 508767004788 DNA binding groove [nucleotide binding] 508767004789 phosphate binding site [ion binding]; other site 508767004790 domain II; other site 508767004791 domain III; other site 508767004792 nucleotide binding site [chemical binding]; other site 508767004793 catalytic site [active] 508767004794 domain IV; other site 508767004795 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 508767004796 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 508767004797 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 508767004798 putative metal binding site [ion binding]; other site 508767004799 Uncharacterized conserved protein [Function unknown]; Region: COG1434 508767004800 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 508767004801 putative active site [active] 508767004802 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 508767004803 active site 508767004804 8-oxo-dGMP binding site [chemical binding]; other site 508767004805 nudix motif; other site 508767004806 metal binding site [ion binding]; metal-binding site 508767004807 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 508767004808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767004809 dimer interface [polypeptide binding]; other site 508767004810 conserved gate region; other site 508767004811 putative PBP binding loops; other site 508767004812 ABC-ATPase subunit interface; other site 508767004813 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 508767004814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767004815 dimer interface [polypeptide binding]; other site 508767004816 conserved gate region; other site 508767004817 putative PBP binding loops; other site 508767004818 ABC-ATPase subunit interface; other site 508767004819 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 508767004820 active site 508767004821 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508767004822 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508767004823 DNA binding site [nucleotide binding] 508767004824 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 508767004825 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 508767004826 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 508767004827 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 508767004828 Ca binding site [ion binding]; other site 508767004829 active site 508767004830 catalytic site [active] 508767004831 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 508767004832 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 508767004833 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 508767004834 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 508767004835 nucleotide binding site [chemical binding]; other site 508767004836 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508767004837 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767004838 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 508767004839 Predicted transcriptional regulator [Transcription]; Region: COG2378 508767004840 HTH domain; Region: HTH_11; pfam08279 508767004841 WYL domain; Region: WYL; pfam13280 508767004842 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 508767004843 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 508767004844 conserved cys residue [active] 508767004845 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 508767004846 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 508767004847 H+ Antiporter protein; Region: 2A0121; TIGR00900 508767004848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508767004849 putative substrate translocation pore; other site 508767004850 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 508767004851 active site 508767004852 dimer interface [polypeptide binding]; other site 508767004853 motif 2; other site 508767004854 motif 3; other site 508767004855 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 508767004856 anticodon binding site; other site 508767004857 Peptidase family S41; Region: Peptidase_S41; pfam03572 508767004858 Active site serine [active] 508767004859 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 508767004860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508767004861 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508767004862 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508767004863 hypothetical protein; Provisional; Region: PRK02399 508767004864 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 508767004865 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 508767004866 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 508767004867 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 508767004868 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 508767004869 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 508767004870 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 508767004871 4Fe-4S binding domain; Region: Fer4; pfam00037 508767004872 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 508767004873 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 508767004874 4Fe-4S binding domain; Region: Fer4; pfam00037 508767004875 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 508767004876 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 508767004877 cobalt transport protein CbiM; Validated; Region: PRK06265 508767004878 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 508767004879 PDGLE domain; Region: PDGLE; pfam13190 508767004880 Cobalt transport protein; Region: CbiQ; cl00463 508767004881 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 508767004882 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 508767004883 Walker A/P-loop; other site 508767004884 ATP binding site [chemical binding]; other site 508767004885 Q-loop/lid; other site 508767004886 ABC transporter signature motif; other site 508767004887 Walker B; other site 508767004888 D-loop; other site 508767004889 H-loop/switch region; other site 508767004890 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 508767004891 transcription elongation factor GreA; Region: greA; TIGR01462 508767004892 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 508767004893 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 508767004894 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508767004895 active site 508767004896 catalytic triad [active] 508767004897 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508767004898 active site 508767004899 catalytic triad [active] 508767004900 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 508767004901 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 508767004902 active site 508767004903 catalytic site [active] 508767004904 substrate binding site [chemical binding]; other site 508767004905 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 508767004906 Dimer interface [polypeptide binding]; other site 508767004907 BRCT sequence motif; other site 508767004908 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 508767004909 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 508767004910 Transcriptional regulator [Transcription]; Region: LysR; COG0583 508767004911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 508767004912 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 508767004913 dimerization interface [polypeptide binding]; other site 508767004914 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 508767004915 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 508767004916 active site 508767004917 catalytic site [active] 508767004918 substrate binding site [chemical binding]; other site 508767004919 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 508767004920 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 508767004921 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508767004922 ABC transporter; Region: ABC_tran_2; pfam12848 508767004923 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508767004924 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 508767004925 Putative glucoamylase; Region: Glycoamylase; pfam10091 508767004926 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 508767004927 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 508767004928 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 508767004929 Protein of unknown function, DUF608; Region: DUF608; pfam04685 508767004930 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 508767004931 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 508767004932 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 508767004933 FMN binding site [chemical binding]; other site 508767004934 dimer interface [polypeptide binding]; other site 508767004935 Transcriptional regulator [Transcription]; Region: LysR; COG0583 508767004936 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 508767004937 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 508767004938 dimerization interface [polypeptide binding]; other site 508767004939 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 508767004940 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 508767004941 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 508767004942 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 508767004943 nickel binding site [ion binding]; other site 508767004944 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 508767004945 Acylphosphatase; Region: Acylphosphatase; pfam00708 508767004946 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 508767004947 HypF finger; Region: zf-HYPF; pfam07503 508767004948 HypF finger; Region: zf-HYPF; pfam07503 508767004949 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 508767004950 HupF/HypC family; Region: HupF_HypC; pfam01455 508767004951 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 508767004952 dimerization interface [polypeptide binding]; other site 508767004953 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 508767004954 ATP binding site [chemical binding]; other site 508767004955 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 508767004956 SLBB domain; Region: SLBB; pfam10531 508767004957 4Fe-4S binding domain; Region: Fer4; pfam00037 508767004958 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 508767004959 4Fe-4S binding domain; Region: Fer4; pfam00037 508767004960 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 508767004961 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 508767004962 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 508767004963 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767004964 dimerization interface [polypeptide binding]; other site 508767004965 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767004966 dimer interface [polypeptide binding]; other site 508767004967 putative CheW interface [polypeptide binding]; other site 508767004968 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 508767004969 Cache domain; Region: Cache_1; pfam02743 508767004970 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767004971 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767004972 dimer interface [polypeptide binding]; other site 508767004973 putative CheW interface [polypeptide binding]; other site 508767004974 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 508767004975 putative catalytic site [active] 508767004976 putative metal binding site [ion binding]; other site 508767004977 putative phosphate binding site [ion binding]; other site 508767004978 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 508767004979 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767004980 Walker A/P-loop; other site 508767004981 ATP binding site [chemical binding]; other site 508767004982 Q-loop/lid; other site 508767004983 ABC transporter signature motif; other site 508767004984 Walker B; other site 508767004985 D-loop; other site 508767004986 H-loop/switch region; other site 508767004987 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 508767004988 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 508767004989 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508767004990 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 508767004991 Walker A/P-loop; other site 508767004992 ATP binding site [chemical binding]; other site 508767004993 Q-loop/lid; other site 508767004994 ABC transporter signature motif; other site 508767004995 Walker B; other site 508767004996 D-loop; other site 508767004997 H-loop/switch region; other site 508767004998 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 508767004999 FtsX-like permease family; Region: FtsX; pfam02687 508767005000 FtsX-like permease family; Region: FtsX; pfam02687 508767005001 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767005002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767005003 active site 508767005004 phosphorylation site [posttranslational modification] 508767005005 intermolecular recognition site; other site 508767005006 dimerization interface [polypeptide binding]; other site 508767005007 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767005008 DNA binding site [nucleotide binding] 508767005009 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767005010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767005011 dimer interface [polypeptide binding]; other site 508767005012 phosphorylation site [posttranslational modification] 508767005013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767005014 ATP binding site [chemical binding]; other site 508767005015 Mg2+ binding site [ion binding]; other site 508767005016 G-X-G motif; other site 508767005017 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 508767005018 pentamer interface [polypeptide binding]; other site 508767005019 dodecaamer interface [polypeptide binding]; other site 508767005020 Transcriptional regulator [Transcription]; Region: LysR; COG0583 508767005021 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 508767005022 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 508767005023 dimerization interface [polypeptide binding]; other site 508767005024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508767005025 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508767005026 putative substrate translocation pore; other site 508767005027 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 508767005028 Sterol carrier protein domain; Region: SCP2_2; pfam13530 508767005029 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 508767005030 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 508767005031 dinuclear metal binding motif [ion binding]; other site 508767005032 TPR repeat; Region: TPR_11; pfam13414 508767005033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508767005034 binding surface 508767005035 TPR motif; other site 508767005036 hybrid cluster protein; Provisional; Region: PRK05290 508767005037 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508767005038 ACS interaction site; other site 508767005039 CODH interaction site; other site 508767005040 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508767005041 ACS interaction site; other site 508767005042 CODH interaction site; other site 508767005043 metal cluster binding site [ion binding]; other site 508767005044 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 508767005045 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 508767005046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767005047 motif II; other site 508767005048 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 508767005049 MutS domain III; Region: MutS_III; pfam05192 508767005050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767005051 Walker A/P-loop; other site 508767005052 ATP binding site [chemical binding]; other site 508767005053 Q-loop/lid; other site 508767005054 ABC transporter signature motif; other site 508767005055 Walker B; other site 508767005056 D-loop; other site 508767005057 H-loop/switch region; other site 508767005058 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 508767005059 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 508767005060 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767005061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767005062 dimer interface [polypeptide binding]; other site 508767005063 phosphorylation site [posttranslational modification] 508767005064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767005065 ATP binding site [chemical binding]; other site 508767005066 Mg2+ binding site [ion binding]; other site 508767005067 G-X-G motif; other site 508767005068 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 508767005069 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 508767005070 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cl00249 508767005071 trimer interface I [polypeptide binding]; other site 508767005072 putative substrate binding pocket [chemical binding]; other site 508767005073 trimer interface II [polypeptide binding]; other site 508767005074 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 508767005075 classical (c) SDRs; Region: SDR_c; cd05233 508767005076 NAD(P) binding site [chemical binding]; other site 508767005077 active site 508767005078 RibD C-terminal domain; Region: RibD_C; cl17279 508767005079 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 508767005080 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 508767005081 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 508767005082 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 508767005083 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 508767005084 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 508767005085 catalytic loop [active] 508767005086 iron binding site [ion binding]; other site 508767005087 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 508767005088 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 508767005089 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 508767005090 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 508767005091 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 508767005092 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 508767005093 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508767005094 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508767005095 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 508767005096 homodimer interface [polypeptide binding]; other site 508767005097 chemical substrate binding site [chemical binding]; other site 508767005098 oligomer interface [polypeptide binding]; other site 508767005099 metal binding site [ion binding]; metal-binding site 508767005100 Amino acid permease; Region: AA_permease_2; pfam13520 508767005101 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 508767005102 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 508767005103 PAS domain S-box; Region: sensory_box; TIGR00229 508767005104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 508767005105 putative active site [active] 508767005106 heme pocket [chemical binding]; other site 508767005107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767005108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767005109 dimer interface [polypeptide binding]; other site 508767005110 phosphorylation site [posttranslational modification] 508767005111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767005112 ATP binding site [chemical binding]; other site 508767005113 Mg2+ binding site [ion binding]; other site 508767005114 G-X-G motif; other site 508767005115 PAS domain S-box; Region: sensory_box; TIGR00229 508767005116 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 508767005117 putative active site [active] 508767005118 heme pocket [chemical binding]; other site 508767005119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767005120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767005121 dimer interface [polypeptide binding]; other site 508767005122 phosphorylation site [posttranslational modification] 508767005123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767005124 ATP binding site [chemical binding]; other site 508767005125 Mg2+ binding site [ion binding]; other site 508767005126 G-X-G motif; other site 508767005127 PAS domain S-box; Region: sensory_box; TIGR00229 508767005128 PAS domain; Region: PAS; smart00091 508767005129 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767005130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767005131 dimer interface [polypeptide binding]; other site 508767005132 phosphorylation site [posttranslational modification] 508767005133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767005134 ATP binding site [chemical binding]; other site 508767005135 Mg2+ binding site [ion binding]; other site 508767005136 G-X-G motif; other site 508767005137 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 508767005138 ATP binding site [chemical binding]; other site 508767005139 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 508767005140 Sel1-like repeats; Region: SEL1; smart00671 508767005141 Sel1-like repeats; Region: SEL1; smart00671 508767005142 Sel1-like repeats; Region: SEL1; smart00671 508767005143 Sel1-like repeats; Region: SEL1; smart00671 508767005144 Sel1-like repeats; Region: SEL1; smart00671 508767005145 Sel1-like repeats; Region: SEL1; smart00671 508767005146 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 508767005147 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 508767005148 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767005149 dimerization interface [polypeptide binding]; other site 508767005150 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767005151 dimer interface [polypeptide binding]; other site 508767005152 putative CheW interface [polypeptide binding]; other site 508767005153 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 508767005154 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 508767005155 active site 508767005156 Zn binding site [ion binding]; other site 508767005157 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 508767005158 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 508767005159 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 508767005160 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 508767005161 active site 508767005162 catalytic tetrad [active] 508767005163 Sensory domain found in PocR; Region: PocR; pfam10114 508767005164 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 508767005165 Histidine kinase; Region: His_kinase; pfam06580 508767005166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767005167 ATP binding site [chemical binding]; other site 508767005168 G-X-G motif; other site 508767005169 Response regulator receiver domain; Region: Response_reg; pfam00072 508767005170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767005171 active site 508767005172 phosphorylation site [posttranslational modification] 508767005173 intermolecular recognition site; other site 508767005174 dimerization interface [polypeptide binding]; other site 508767005175 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508767005176 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508767005177 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508767005178 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 508767005179 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 508767005180 dimer interface [polypeptide binding]; other site 508767005181 active site 508767005182 glycine loop; other site 508767005183 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 508767005184 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 508767005185 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767005186 FeS/SAM binding site; other site 508767005187 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 508767005188 active site 508767005189 metal binding site [ion binding]; metal-binding site 508767005190 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 508767005191 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 508767005192 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 508767005193 nudix motif; other site 508767005194 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 508767005195 nudix motif; other site 508767005196 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 508767005197 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 508767005198 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 508767005199 Putative amidase domain; Region: Amidase_6; pfam12671 508767005200 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 508767005201 phytoene desaturase; Region: crtI_fam; TIGR02734 508767005202 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 508767005203 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 508767005204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767005205 Walker A/P-loop; other site 508767005206 ATP binding site [chemical binding]; other site 508767005207 Q-loop/lid; other site 508767005208 ABC transporter signature motif; other site 508767005209 Walker B; other site 508767005210 D-loop; other site 508767005211 H-loop/switch region; other site 508767005212 ABC transporter; Region: ABC_tran_2; pfam12848 508767005213 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508767005214 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 508767005215 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 508767005216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508767005217 ATP binding site [chemical binding]; other site 508767005218 putative Mg++ binding site [ion binding]; other site 508767005219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508767005220 nucleotide binding region [chemical binding]; other site 508767005221 ATP-binding site [chemical binding]; other site 508767005222 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 508767005223 MgtC family; Region: MgtC; pfam02308 508767005224 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 508767005225 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 508767005226 active site 508767005227 catalytic site [active] 508767005228 metal binding site [ion binding]; metal-binding site 508767005229 dimer interface [polypeptide binding]; other site 508767005230 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 508767005231 MgtC family; Region: MgtC; pfam02308 508767005232 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 508767005233 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 508767005234 oligomerization interface [polypeptide binding]; other site 508767005235 active site 508767005236 metal binding site [ion binding]; metal-binding site 508767005237 Pantoate-beta-alanine ligase; Region: PanC; cd00560 508767005238 pantoate--beta-alanine ligase; Region: panC; TIGR00018 508767005239 active site 508767005240 ATP-binding site [chemical binding]; other site 508767005241 pantoate-binding site; other site 508767005242 HXXH motif; other site 508767005243 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 508767005244 tetramerization interface [polypeptide binding]; other site 508767005245 active site 508767005246 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767005247 Radical SAM superfamily; Region: Radical_SAM; pfam04055 508767005248 FeS/SAM binding site; other site 508767005249 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 508767005250 MutS domain I; Region: MutS_I; pfam01624 508767005251 MutS domain II; Region: MutS_II; pfam05188 508767005252 MutS domain III; Region: MutS_III; pfam05192 508767005253 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 508767005254 Walker A/P-loop; other site 508767005255 ATP binding site [chemical binding]; other site 508767005256 Q-loop/lid; other site 508767005257 ABC transporter signature motif; other site 508767005258 Walker B; other site 508767005259 D-loop; other site 508767005260 H-loop/switch region; other site 508767005261 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 508767005262 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508767005263 active site turn [active] 508767005264 phosphorylation site [posttranslational modification] 508767005265 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 508767005266 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 508767005267 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 508767005268 Ca binding site [ion binding]; other site 508767005269 active site 508767005270 catalytic site [active] 508767005271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508767005272 DNA-binding site [nucleotide binding]; DNA binding site 508767005273 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 508767005274 UTRA domain; Region: UTRA; pfam07702 508767005275 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 508767005276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767005277 ATP binding site [chemical binding]; other site 508767005278 Mg2+ binding site [ion binding]; other site 508767005279 G-X-G motif; other site 508767005280 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 508767005281 ATP binding site [chemical binding]; other site 508767005282 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 508767005283 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 508767005284 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 508767005285 bacterial Hfq-like; Region: Hfq; cd01716 508767005286 hexamer interface [polypeptide binding]; other site 508767005287 Sm1 motif; other site 508767005288 RNA binding site [nucleotide binding]; other site 508767005289 Sm2 motif; other site 508767005290 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 508767005291 Aluminium resistance protein; Region: Alum_res; pfam06838 508767005292 LexA repressor; Validated; Region: PRK00215 508767005293 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508767005294 putative DNA binding site [nucleotide binding]; other site 508767005295 putative Zn2+ binding site [ion binding]; other site 508767005296 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 508767005297 Catalytic site [active] 508767005298 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 508767005299 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508767005300 active site 508767005301 DNA binding site [nucleotide binding] 508767005302 Int/Topo IB signature motif; other site 508767005303 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 508767005304 putative deacylase active site [active] 508767005305 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 508767005306 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 508767005307 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767005308 FeS/SAM binding site; other site 508767005309 TRAM domain; Region: TRAM; pfam01938 508767005310 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508767005311 non-specific DNA binding site [nucleotide binding]; other site 508767005312 salt bridge; other site 508767005313 sequence-specific DNA binding site [nucleotide binding]; other site 508767005314 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 508767005315 catalytic residue [active] 508767005316 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 508767005317 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 508767005318 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 508767005319 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 508767005320 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 508767005321 Domain of unknown function DUF11; Region: DUF11; pfam01345 508767005322 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 508767005323 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 508767005324 Baseplate J-like protein; Region: Baseplate_J; pfam04865 508767005325 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 508767005326 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 508767005327 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 508767005328 Mu-like prophage protein [General function prediction only]; Region: COG3941 508767005329 Phage-related protein [Function unknown]; Region: COG5412 508767005330 Phage tail tube protein FII; Region: Phage_tube; cl01390 508767005331 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 508767005332 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 508767005333 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 508767005334 oligomer interface [polypeptide binding]; other site 508767005335 active site residues [active] 508767005336 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 508767005337 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 508767005338 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 508767005339 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 508767005340 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508767005341 active site 508767005342 DNA binding site [nucleotide binding] 508767005343 Int/Topo IB signature motif; other site 508767005344 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 508767005345 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 508767005346 metal binding site [ion binding]; metal-binding site 508767005347 dimer interface [polypeptide binding]; other site 508767005348 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 508767005349 Coat F domain; Region: Coat_F; pfam07875 508767005350 Helix-turn-helix domain; Region: HTH_36; pfam13730 508767005351 ParB-like nuclease domain; Region: ParBc; pfam02195 508767005352 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 508767005353 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 508767005354 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 508767005355 P-loop; other site 508767005356 Magnesium ion binding site [ion binding]; other site 508767005357 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 508767005358 Magnesium ion binding site [ion binding]; other site 508767005359 Helix-turn-helix domain; Region: HTH_31; pfam13560 508767005360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508767005361 non-specific DNA binding site [nucleotide binding]; other site 508767005362 salt bridge; other site 508767005363 sequence-specific DNA binding site [nucleotide binding]; other site 508767005364 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 508767005365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508767005366 non-specific DNA binding site [nucleotide binding]; other site 508767005367 salt bridge; other site 508767005368 sequence-specific DNA binding site [nucleotide binding]; other site 508767005369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 508767005370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 508767005371 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 508767005372 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 508767005373 catalytic residues [active] 508767005374 catalytic nucleophile [active] 508767005375 Presynaptic Site I dimer interface [polypeptide binding]; other site 508767005376 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 508767005377 Synaptic Flat tetramer interface [polypeptide binding]; other site 508767005378 Synaptic Site I dimer interface [polypeptide binding]; other site 508767005379 DNA binding site [nucleotide binding] 508767005380 Recombinase; Region: Recombinase; pfam07508 508767005381 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 508767005382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767005383 Coenzyme A binding pocket [chemical binding]; other site 508767005384 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 508767005385 LytB protein; Region: LYTB; cl00507 508767005386 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 508767005387 RNA binding site [nucleotide binding]; other site 508767005388 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 508767005389 RNA binding site [nucleotide binding]; other site 508767005390 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 508767005391 RNA binding site [nucleotide binding]; other site 508767005392 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 508767005393 RNA binding site [nucleotide binding]; other site 508767005394 cytidylate kinase; Provisional; Region: cmk; PRK00023 508767005395 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 508767005396 CMP-binding site; other site 508767005397 The sites determining sugar specificity; other site 508767005398 HI0933-like protein; Region: HI0933_like; pfam03486 508767005399 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508767005400 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 508767005401 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 508767005402 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 508767005403 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 508767005404 Na binding site [ion binding]; other site 508767005405 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 508767005406 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 508767005407 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 508767005408 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 508767005409 putative active site [active] 508767005410 heme pocket [chemical binding]; other site 508767005411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767005412 Walker A motif; other site 508767005413 ATP binding site [chemical binding]; other site 508767005414 Walker B motif; other site 508767005415 arginine finger; other site 508767005416 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 508767005417 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 508767005418 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 508767005419 putative active site [active] 508767005420 putative CoA binding site [chemical binding]; other site 508767005421 nudix motif; other site 508767005422 metal binding site [ion binding]; metal-binding site 508767005423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 508767005424 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 508767005425 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 508767005426 active site 508767005427 PHP-associated; Region: PHP_C; pfam13263 508767005428 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 508767005429 Protein of unknown function, DUF488; Region: DUF488; pfam04343 508767005430 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 508767005431 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 508767005432 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 508767005433 Walker A/P-loop; other site 508767005434 ATP binding site [chemical binding]; other site 508767005435 Q-loop/lid; other site 508767005436 ABC transporter signature motif; other site 508767005437 Walker B; other site 508767005438 D-loop; other site 508767005439 H-loop/switch region; other site 508767005440 Predicted transcriptional regulators [Transcription]; Region: COG1725 508767005441 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508767005442 DNA-binding site [nucleotide binding]; DNA binding site 508767005443 manganese transport transcriptional regulator; Provisional; Region: PRK03902 508767005444 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 508767005445 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 508767005446 FeoA domain; Region: FeoA; pfam04023 508767005447 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 508767005448 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 508767005449 G1 box; other site 508767005450 GTP/Mg2+ binding site [chemical binding]; other site 508767005451 Switch I region; other site 508767005452 G2 box; other site 508767005453 G3 box; other site 508767005454 Switch II region; other site 508767005455 G4 box; other site 508767005456 G5 box; other site 508767005457 Nucleoside recognition; Region: Gate; pfam07670 508767005458 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 508767005459 Nucleoside recognition; Region: Gate; pfam07670 508767005460 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767005461 dimerization interface [polypeptide binding]; other site 508767005462 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767005463 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767005464 dimer interface [polypeptide binding]; other site 508767005465 putative CheW interface [polypeptide binding]; other site 508767005466 TraX protein; Region: TraX; pfam05857 508767005467 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767005468 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767005469 dimer interface [polypeptide binding]; other site 508767005470 phosphorylation site [posttranslational modification] 508767005471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767005472 ATP binding site [chemical binding]; other site 508767005473 Mg2+ binding site [ion binding]; other site 508767005474 G-X-G motif; other site 508767005475 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767005476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767005477 active site 508767005478 phosphorylation site [posttranslational modification] 508767005479 intermolecular recognition site; other site 508767005480 dimerization interface [polypeptide binding]; other site 508767005481 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767005482 DNA binding site [nucleotide binding] 508767005483 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 508767005484 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 508767005485 Walker A/P-loop; other site 508767005486 ATP binding site [chemical binding]; other site 508767005487 Q-loop/lid; other site 508767005488 ABC transporter signature motif; other site 508767005489 Walker B; other site 508767005490 D-loop; other site 508767005491 H-loop/switch region; other site 508767005492 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 508767005493 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 508767005494 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 508767005495 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 508767005496 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 508767005497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767005498 catalytic residue [active] 508767005499 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 508767005500 Family description; Region: UvrD_C_2; pfam13538 508767005501 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 508767005502 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 508767005503 PhnA protein; Region: PhnA; pfam03831 508767005504 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 508767005505 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508767005506 ligand binding site [chemical binding]; other site 508767005507 flexible hinge region; other site 508767005508 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 508767005509 putative switch regulator; other site 508767005510 non-specific DNA interactions [nucleotide binding]; other site 508767005511 DNA binding site [nucleotide binding] 508767005512 sequence specific DNA binding site [nucleotide binding]; other site 508767005513 putative cAMP binding site [chemical binding]; other site 508767005514 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 508767005515 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767005516 Coenzyme A binding pocket [chemical binding]; other site 508767005517 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 508767005518 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508767005519 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508767005520 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 508767005521 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 508767005522 active site residue [active] 508767005523 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 508767005524 active site residue [active] 508767005525 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508767005526 MarR family; Region: MarR; pfam01047 508767005527 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 508767005528 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 508767005529 FAD binding site [chemical binding]; other site 508767005530 homotetramer interface [polypeptide binding]; other site 508767005531 substrate binding pocket [chemical binding]; other site 508767005532 catalytic base [active] 508767005533 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 508767005534 Coenzyme A transferase; Region: CoA_trans; smart00882 508767005535 Coenzyme A transferase; Region: CoA_trans; cl17247 508767005536 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 508767005537 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 508767005538 substrate binding site [chemical binding]; other site 508767005539 oxyanion hole (OAH) forming residues; other site 508767005540 trimer interface [polypeptide binding]; other site 508767005541 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767005542 dimer interface [polypeptide binding]; other site 508767005543 putative CheW interface [polypeptide binding]; other site 508767005544 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 508767005545 dinuclear metal binding motif [ion binding]; other site 508767005546 maltose O-acetyltransferase; Provisional; Region: PRK10092 508767005547 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 508767005548 active site 508767005549 substrate binding site [chemical binding]; other site 508767005550 trimer interface [polypeptide binding]; other site 508767005551 CoA binding site [chemical binding]; other site 508767005552 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 508767005553 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508767005554 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508767005555 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 508767005556 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 508767005557 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 508767005558 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767005559 FeS/SAM binding site; other site 508767005560 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 508767005561 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 508767005562 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 508767005563 peptide binding site [polypeptide binding]; other site 508767005564 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 508767005565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767005566 dimer interface [polypeptide binding]; other site 508767005567 conserved gate region; other site 508767005568 putative PBP binding loops; other site 508767005569 ABC-ATPase subunit interface; other site 508767005570 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 508767005571 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 508767005572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767005573 dimer interface [polypeptide binding]; other site 508767005574 conserved gate region; other site 508767005575 putative PBP binding loops; other site 508767005576 ABC-ATPase subunit interface; other site 508767005577 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 508767005578 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 508767005579 Walker A/P-loop; other site 508767005580 ATP binding site [chemical binding]; other site 508767005581 Q-loop/lid; other site 508767005582 ABC transporter signature motif; other site 508767005583 Walker B; other site 508767005584 D-loop; other site 508767005585 H-loop/switch region; other site 508767005586 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 508767005587 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 508767005588 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 508767005589 Walker A/P-loop; other site 508767005590 ATP binding site [chemical binding]; other site 508767005591 Q-loop/lid; other site 508767005592 ABC transporter signature motif; other site 508767005593 Walker B; other site 508767005594 D-loop; other site 508767005595 H-loop/switch region; other site 508767005596 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 508767005597 hypothetical protein; Provisional; Region: PRK11770 508767005598 Domain of unknown function (DUF307); Region: DUF307; pfam03733 508767005599 Domain of unknown function (DUF307); Region: DUF307; pfam03733 508767005600 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 508767005601 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 508767005602 Substrate-binding site [chemical binding]; other site 508767005603 Substrate specificity [chemical binding]; other site 508767005604 Uncharacterized conserved protein [Function unknown]; Region: COG1434 508767005605 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 508767005606 putative active site [active] 508767005607 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 508767005608 AAA domain; Region: AAA_18; pfam13238 508767005609 active site 508767005610 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 508767005611 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767005612 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767005613 dimer interface [polypeptide binding]; other site 508767005614 phosphorylation site [posttranslational modification] 508767005615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767005616 ATP binding site [chemical binding]; other site 508767005617 Mg2+ binding site [ion binding]; other site 508767005618 G-X-G motif; other site 508767005619 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767005620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767005621 active site 508767005622 phosphorylation site [posttranslational modification] 508767005623 intermolecular recognition site; other site 508767005624 dimerization interface [polypeptide binding]; other site 508767005625 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767005626 DNA binding site [nucleotide binding] 508767005627 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 508767005628 putative homodimer interface [polypeptide binding]; other site 508767005629 putative homotetramer interface [polypeptide binding]; other site 508767005630 putative allosteric switch controlling residues; other site 508767005631 putative metal binding site [ion binding]; other site 508767005632 putative homodimer-homodimer interface [polypeptide binding]; other site 508767005633 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 508767005634 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 508767005635 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 508767005636 DHHA1 domain; Region: DHHA1; pfam02272 508767005637 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 508767005638 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 508767005639 putative hexamer interface [polypeptide binding]; other site 508767005640 putative hexagonal pore; other site 508767005641 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 508767005642 putative hexamer interface [polypeptide binding]; other site 508767005643 putative hexagonal pore; other site 508767005644 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 508767005645 SLBB domain; Region: SLBB; pfam10531 508767005646 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 508767005647 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 508767005648 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 508767005649 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 508767005650 putative catalytic cysteine [active] 508767005651 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 508767005652 Hexamer/Pentamer interface [polypeptide binding]; other site 508767005653 central pore; other site 508767005654 Flavoprotein; Region: Flavoprotein; cl08021 508767005655 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 508767005656 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 508767005657 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 508767005658 nucleotide binding site [chemical binding]; other site 508767005659 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 508767005660 Propanediol utilisation protein PduL; Region: PduL; pfam06130 508767005661 Propanediol utilisation protein PduL; Region: PduL; pfam06130 508767005662 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 508767005663 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 508767005664 Hexamer interface [polypeptide binding]; other site 508767005665 Putative hexagonal pore residue; other site 508767005666 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 508767005667 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 508767005668 Hexamer interface [polypeptide binding]; other site 508767005669 Putative hexagonal pore residue; other site 508767005670 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 508767005671 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 508767005672 Hexamer interface [polypeptide binding]; other site 508767005673 Hexagonal pore residue; other site 508767005674 propanediol utilization protein PduB; Provisional; Region: PRK15415 508767005675 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 508767005676 putative hexamer interface [polypeptide binding]; other site 508767005677 putative hexagonal pore; other site 508767005678 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 508767005679 putative hexamer interface [polypeptide binding]; other site 508767005680 putative hexagonal pore; other site 508767005681 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508767005682 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 508767005683 putative active site [active] 508767005684 metal binding site [ion binding]; metal-binding site 508767005685 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 508767005686 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 508767005687 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 508767005688 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 508767005689 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 508767005690 G1 box; other site 508767005691 putative GEF interaction site [polypeptide binding]; other site 508767005692 GTP/Mg2+ binding site [chemical binding]; other site 508767005693 Switch I region; other site 508767005694 G2 box; other site 508767005695 G3 box; other site 508767005696 Switch II region; other site 508767005697 G4 box; other site 508767005698 G5 box; other site 508767005699 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 508767005700 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 508767005701 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 508767005702 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 508767005703 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 508767005704 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 508767005705 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 508767005706 active site 508767005707 putative catalytic site [active] 508767005708 DNA binding site [nucleotide binding] 508767005709 putative phosphate binding site [ion binding]; other site 508767005710 metal binding site A [ion binding]; metal-binding site 508767005711 AP binding site [nucleotide binding]; other site 508767005712 metal binding site B [ion binding]; metal-binding site 508767005713 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767005714 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767005715 dimer interface [polypeptide binding]; other site 508767005716 putative CheW interface [polypeptide binding]; other site 508767005717 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 508767005718 hypothetical protein; Provisional; Region: PRK00955 508767005719 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 508767005720 EDD domain protein, DegV family; Region: DegV; TIGR00762 508767005721 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 508767005722 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 508767005723 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 508767005724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508767005725 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508767005726 putative substrate translocation pore; other site 508767005727 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 508767005728 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 508767005729 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 508767005730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767005731 active site 508767005732 phosphorylation site [posttranslational modification] 508767005733 intermolecular recognition site; other site 508767005734 dimerization interface [polypeptide binding]; other site 508767005735 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508767005736 Zn2+ binding site [ion binding]; other site 508767005737 Mg2+ binding site [ion binding]; other site 508767005738 HAMP domain; Region: HAMP; pfam00672 508767005739 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767005740 dimer interface [polypeptide binding]; other site 508767005741 phosphorylation site [posttranslational modification] 508767005742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767005743 ATP binding site [chemical binding]; other site 508767005744 Mg2+ binding site [ion binding]; other site 508767005745 G-X-G motif; other site 508767005746 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 508767005747 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 508767005748 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 508767005749 DNA binding residues [nucleotide binding] 508767005750 dimerization interface [polypeptide binding]; other site 508767005751 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767005752 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767005753 dimer interface [polypeptide binding]; other site 508767005754 putative CheW interface [polypeptide binding]; other site 508767005755 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 508767005756 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 508767005757 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767005758 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767005759 dimer interface [polypeptide binding]; other site 508767005760 putative CheW interface [polypeptide binding]; other site 508767005761 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 508767005762 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 508767005763 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 508767005764 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 508767005765 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 508767005766 DXD motif; other site 508767005767 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 508767005768 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508767005769 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508767005770 metal binding site [ion binding]; metal-binding site 508767005771 I-site; other site 508767005772 QueT transporter; Region: QueT; pfam06177 508767005773 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 508767005774 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 508767005775 NAD binding site [chemical binding]; other site 508767005776 homodimer interface [polypeptide binding]; other site 508767005777 active site 508767005778 substrate binding site [chemical binding]; other site 508767005779 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 508767005780 synthetase active site [active] 508767005781 NTP binding site [chemical binding]; other site 508767005782 metal binding site [ion binding]; metal-binding site 508767005783 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 508767005784 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 508767005785 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 508767005786 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 508767005787 DNA binding site [nucleotide binding] 508767005788 active site 508767005789 purine nucleoside phosphorylase; Provisional; Region: PRK08202 508767005790 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 508767005791 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 508767005792 active site 508767005793 HIGH motif; other site 508767005794 dimer interface [polypeptide binding]; other site 508767005795 KMSKS motif; other site 508767005796 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 508767005797 RNA binding surface [nucleotide binding]; other site 508767005798 T-box leader 508767005799 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 508767005800 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 508767005801 active site 508767005802 putative substrate binding pocket [chemical binding]; other site 508767005803 pyruvate carboxylase; Reviewed; Region: PRK12999 508767005804 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 508767005805 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 508767005806 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 508767005807 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 508767005808 active site 508767005809 catalytic residues [active] 508767005810 metal binding site [ion binding]; metal-binding site 508767005811 homodimer binding site [polypeptide binding]; other site 508767005812 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 508767005813 carboxyltransferase (CT) interaction site; other site 508767005814 biotinylation site [posttranslational modification]; other site 508767005815 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508767005816 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 508767005817 xanthine phosphoribosyltransferase; Validated; Region: PRK09219 508767005818 xanthine permease; Region: pbuX; TIGR03173 508767005819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508767005820 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508767005821 putative substrate translocation pore; other site 508767005822 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 508767005823 putative efflux protein, MATE family; Region: matE; TIGR00797 508767005824 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 508767005825 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 508767005826 active site 508767005827 catalytic site [active] 508767005828 substrate binding site [chemical binding]; other site 508767005829 DEAD/DEAH box helicase; Region: DEAD; pfam00270 508767005830 ATP binding site [chemical binding]; other site 508767005831 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 508767005832 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 508767005833 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767005834 Mor transcription activator family; Region: Mor; cl02360 508767005835 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 508767005836 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 508767005837 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 508767005838 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767005839 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767005840 dimer interface [polypeptide binding]; other site 508767005841 phosphorylation site [posttranslational modification] 508767005842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767005843 ATP binding site [chemical binding]; other site 508767005844 Mg2+ binding site [ion binding]; other site 508767005845 G-X-G motif; other site 508767005846 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767005847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767005848 active site 508767005849 phosphorylation site [posttranslational modification] 508767005850 intermolecular recognition site; other site 508767005851 dimerization interface [polypeptide binding]; other site 508767005852 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767005853 DNA binding site [nucleotide binding] 508767005854 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 508767005855 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 508767005856 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 508767005857 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 508767005858 HipA-like C-terminal domain; Region: HipA_C; pfam07804 508767005859 Fic/DOC family; Region: Fic; pfam02661 508767005860 DNA-sulfur modification-associated; Region: DndB; cl17621 508767005861 DGQHR domain; Region: DGQHR; TIGR03187 508767005862 hypothetical protein; Provisional; Region: PRK06850 508767005863 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 508767005864 Ligand Binding Site [chemical binding]; other site 508767005865 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 508767005866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767005867 Walker A/P-loop; other site 508767005868 ATP binding site [chemical binding]; other site 508767005869 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 508767005870 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 508767005871 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 508767005872 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508767005873 catalytic residue [active] 508767005874 Uncharacterized conserved protein [Function unknown]; Region: COG1479 508767005875 Protein of unknown function DUF262; Region: DUF262; pfam03235 508767005876 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 508767005877 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 508767005878 AAA-like domain; Region: AAA_10; pfam12846 508767005879 Domain of unknown function DUF87; Region: DUF87; pfam01935 508767005880 DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236 508767005881 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 508767005882 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 508767005883 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 508767005884 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 508767005885 amphipathic channel; other site 508767005886 Asn-Pro-Ala signature motifs; other site 508767005887 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508767005888 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 508767005889 dimer interface [polypeptide binding]; other site 508767005890 active site 508767005891 metal binding site [ion binding]; metal-binding site 508767005892 Domain of unknown function (DUF336); Region: DUF336; pfam03928 508767005893 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 508767005894 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 508767005895 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 508767005896 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 508767005897 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 508767005898 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 508767005899 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 508767005900 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 508767005901 alpha-beta subunit interface [polypeptide binding]; other site 508767005902 alpha-gamma subunit interface [polypeptide binding]; other site 508767005903 active site 508767005904 substrate and K+ binding site; other site 508767005905 K+ binding site [ion binding]; other site 508767005906 cobalamin binding site [chemical binding]; other site 508767005907 Response regulator receiver domain; Region: Response_reg; pfam00072 508767005908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767005909 active site 508767005910 phosphorylation site [posttranslational modification] 508767005911 intermolecular recognition site; other site 508767005912 dimerization interface [polypeptide binding]; other site 508767005913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508767005914 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508767005915 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508767005916 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 508767005917 Sensory domain found in PocR; Region: PocR; pfam10114 508767005918 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 508767005919 Histidine kinase; Region: His_kinase; pfam06580 508767005920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767005921 ATP binding site [chemical binding]; other site 508767005922 Mg2+ binding site [ion binding]; other site 508767005923 G-X-G motif; other site 508767005924 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 508767005925 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767005926 Divergent AAA domain; Region: AAA_4; pfam04326 508767005927 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 508767005928 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 508767005929 active site 508767005930 NTP binding site [chemical binding]; other site 508767005931 metal binding triad [ion binding]; metal-binding site 508767005932 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552 508767005933 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 508767005934 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 508767005935 active site 508767005936 catalytic tetrad [active] 508767005937 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 508767005938 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 508767005939 Walker A/P-loop; other site 508767005940 ATP binding site [chemical binding]; other site 508767005941 Q-loop/lid; other site 508767005942 ABC transporter signature motif; other site 508767005943 Walker B; other site 508767005944 D-loop; other site 508767005945 H-loop/switch region; other site 508767005946 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 508767005947 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508767005948 ABC-ATPase subunit interface; other site 508767005949 dimer interface [polypeptide binding]; other site 508767005950 putative PBP binding regions; other site 508767005951 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 508767005952 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508767005953 ABC-ATPase subunit interface; other site 508767005954 dimer interface [polypeptide binding]; other site 508767005955 putative PBP binding regions; other site 508767005956 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 508767005957 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 508767005958 putative ligand binding residues [chemical binding]; other site 508767005959 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 508767005960 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 508767005961 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508767005962 active site turn [active] 508767005963 phosphorylation site [posttranslational modification] 508767005964 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 508767005965 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 508767005966 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 508767005967 Ca binding site [ion binding]; other site 508767005968 active site 508767005969 catalytic site [active] 508767005970 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767005971 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508767005972 active site 508767005973 motif I; other site 508767005974 motif II; other site 508767005975 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767005976 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 508767005977 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 508767005978 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 508767005979 putative active site [active] 508767005980 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 508767005981 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 508767005982 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 508767005983 putative active site [active] 508767005984 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 508767005985 hypothetical protein; Provisional; Region: PRK06771 508767005986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767005987 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 508767005988 Coenzyme A binding pocket [chemical binding]; other site 508767005989 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 508767005990 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 508767005991 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 508767005992 putative active site [active] 508767005993 putative metal binding site [ion binding]; other site 508767005994 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 508767005995 dimer interface [polypeptide binding]; other site 508767005996 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 508767005997 ligand binding site [chemical binding]; other site 508767005998 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 508767005999 putative dimer interface [polypeptide binding]; other site 508767006000 catalytic triad [active] 508767006001 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 508767006002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767006003 Coenzyme A binding pocket [chemical binding]; other site 508767006004 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 508767006005 maltose O-acetyltransferase; Provisional; Region: PRK10092 508767006006 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 508767006007 active site 508767006008 substrate binding site [chemical binding]; other site 508767006009 trimer interface [polypeptide binding]; other site 508767006010 CoA binding site [chemical binding]; other site 508767006011 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 508767006012 stage II sporulation protein P; Region: spore_II_P; TIGR02867 508767006013 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 508767006014 Penicillinase repressor; Region: Pencillinase_R; pfam03965 508767006015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767006016 Coenzyme A binding pocket [chemical binding]; other site 508767006017 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508767006018 non-specific DNA binding site [nucleotide binding]; other site 508767006019 salt bridge; other site 508767006020 sequence-specific DNA binding site [nucleotide binding]; other site 508767006021 Predicted acetyltransferase [General function prediction only]; Region: COG3981 508767006022 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508767006023 Coenzyme A binding pocket [chemical binding]; other site 508767006024 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 508767006025 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767006026 Coenzyme A binding pocket [chemical binding]; other site 508767006027 Sensory domain found in PocR; Region: PocR; pfam10114 508767006028 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 508767006029 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767006030 dimer interface [polypeptide binding]; other site 508767006031 putative CheW interface [polypeptide binding]; other site 508767006032 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508767006033 dimerization interface [polypeptide binding]; other site 508767006034 putative DNA binding site [nucleotide binding]; other site 508767006035 putative Zn2+ binding site [ion binding]; other site 508767006036 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 508767006037 Predicted integral membrane protein [Function unknown]; Region: COG5658 508767006038 SdpI/YhfL protein family; Region: SdpI; pfam13630 508767006039 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 508767006040 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 508767006041 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 508767006042 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 508767006043 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 508767006044 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 508767006045 active site 508767006046 NTP binding site [chemical binding]; other site 508767006047 metal binding triad [ion binding]; metal-binding site 508767006048 Cache domain; Region: Cache_1; pfam02743 508767006049 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 508767006050 HAMP domain; Region: HAMP; pfam00672 508767006051 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767006052 dimer interface [polypeptide binding]; other site 508767006053 putative CheW interface [polypeptide binding]; other site 508767006054 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 508767006055 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 508767006056 putative catalytic cysteine [active] 508767006057 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 508767006058 putative active site [active] 508767006059 metal binding site [ion binding]; metal-binding site 508767006060 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 508767006061 RNA polymerase factor sigma-70; Validated; Region: PRK06811 508767006062 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508767006063 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 508767006064 DNA binding residues [nucleotide binding] 508767006065 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 508767006066 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 508767006067 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 508767006068 Protein of unknown function DUF86; Region: DUF86; pfam01934 508767006069 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 508767006070 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767006071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767006072 dimer interface [polypeptide binding]; other site 508767006073 phosphorylation site [posttranslational modification] 508767006074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767006075 ATP binding site [chemical binding]; other site 508767006076 Mg2+ binding site [ion binding]; other site 508767006077 G-X-G motif; other site 508767006078 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767006079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767006080 active site 508767006081 phosphorylation site [posttranslational modification] 508767006082 intermolecular recognition site; other site 508767006083 dimerization interface [polypeptide binding]; other site 508767006084 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767006085 DNA binding site [nucleotide binding] 508767006086 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 508767006087 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 508767006088 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 508767006089 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 508767006090 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 508767006091 Walker A/P-loop; other site 508767006092 ATP binding site [chemical binding]; other site 508767006093 Q-loop/lid; other site 508767006094 ABC transporter signature motif; other site 508767006095 Walker B; other site 508767006096 D-loop; other site 508767006097 H-loop/switch region; other site 508767006098 Protein of unknown function DUF45; Region: DUF45; pfam01863 508767006099 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 508767006100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 508767006101 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 508767006102 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 508767006103 NlpC/P60 family; Region: NLPC_P60; pfam00877 508767006104 Predicted thioesterase [General function prediction only]; Region: COG5496 508767006105 Der1-like family; Region: DER1; cl17806 508767006106 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 508767006107 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508767006108 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508767006109 DNA binding residues [nucleotide binding] 508767006110 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 508767006111 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 508767006112 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508767006113 active site 508767006114 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 508767006115 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 508767006116 5S rRNA interface [nucleotide binding]; other site 508767006117 CTC domain interface [polypeptide binding]; other site 508767006118 L16 interface [polypeptide binding]; other site 508767006119 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 508767006120 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 508767006121 5S rRNA interface [nucleotide binding]; other site 508767006122 CTC domain interface [polypeptide binding]; other site 508767006123 L16 interface [polypeptide binding]; other site 508767006124 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508767006125 ATP binding site [chemical binding]; other site 508767006126 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 508767006127 putative Mg++ binding site [ion binding]; other site 508767006128 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508767006129 nucleotide binding region [chemical binding]; other site 508767006130 ATP-binding site [chemical binding]; other site 508767006131 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 508767006132 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 508767006133 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 508767006134 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 508767006135 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 508767006136 active site 508767006137 catalytic residue [active] 508767006138 dimer interface [polypeptide binding]; other site 508767006139 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 508767006140 peptidase T; Region: peptidase-T; TIGR01882 508767006141 metal binding site [ion binding]; metal-binding site 508767006142 dimer interface [polypeptide binding]; other site 508767006143 Protein of unknown function (DUF342); Region: DUF342; pfam03961 508767006144 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767006145 Bacterial SH3 domain; Region: SH3_3; pfam08239 508767006146 Surface antigen [General function prediction only]; Region: COG3942 508767006147 CHAP domain; Region: CHAP; pfam05257 508767006148 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 508767006149 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 508767006150 putative active site [active] 508767006151 heme pocket [chemical binding]; other site 508767006152 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508767006153 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508767006154 metal binding site [ion binding]; metal-binding site 508767006155 active site 508767006156 I-site; other site 508767006157 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508767006158 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508767006159 metal binding site [ion binding]; metal-binding site 508767006160 active site 508767006161 I-site; other site 508767006162 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 508767006163 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 508767006164 PAS domain; Region: PAS_9; pfam13426 508767006165 putative active site [active] 508767006166 heme pocket [chemical binding]; other site 508767006167 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508767006168 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508767006169 metal binding site [ion binding]; metal-binding site 508767006170 active site 508767006171 I-site; other site 508767006172 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508767006173 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508767006174 metal binding site [ion binding]; metal-binding site 508767006175 active site 508767006176 I-site; other site 508767006177 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 508767006178 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 508767006179 Ligand Binding Site [chemical binding]; other site 508767006180 TIGR00269 family protein; Region: TIGR00269 508767006181 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 508767006182 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 508767006183 Low molecular weight phosphatase family; Region: LMWPc; cl00105 508767006184 active site 508767006185 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508767006186 dimerization interface [polypeptide binding]; other site 508767006187 putative DNA binding site [nucleotide binding]; other site 508767006188 putative Zn2+ binding site [ion binding]; other site 508767006189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767006190 Coenzyme A binding pocket [chemical binding]; other site 508767006191 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508767006192 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 508767006193 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 508767006194 active site 508767006195 phosphorylation site [posttranslational modification] 508767006196 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 508767006197 active site 508767006198 P-loop; other site 508767006199 phosphorylation site [posttranslational modification] 508767006200 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 508767006201 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 508767006202 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 508767006203 putative substrate binding site [chemical binding]; other site 508767006204 putative ATP binding site [chemical binding]; other site 508767006205 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 508767006206 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 508767006207 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 508767006208 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 508767006209 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 508767006210 active site 508767006211 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 508767006212 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508767006213 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 508767006214 catalytic core [active] 508767006215 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 508767006216 catalytic loop [active] 508767006217 iron binding site [ion binding]; other site 508767006218 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 508767006219 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508767006220 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 508767006221 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 508767006222 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 508767006223 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 508767006224 dimer interface [polypeptide binding]; other site 508767006225 [2Fe-2S] cluster binding site [ion binding]; other site 508767006226 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 508767006227 SLBB domain; Region: SLBB; pfam10531 508767006228 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 508767006229 4Fe-4S binding domain; Region: Fer4; pfam00037 508767006230 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 508767006231 4Fe-4S binding domain; Region: Fer4; cl02805 508767006232 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 508767006233 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 508767006234 putative dimer interface [polypeptide binding]; other site 508767006235 [2Fe-2S] cluster binding site [ion binding]; other site 508767006236 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 508767006237 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 508767006238 putative active site [active] 508767006239 catalytic site [active] 508767006240 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 508767006241 putative active site [active] 508767006242 catalytic site [active] 508767006243 Domain of unknown function DUF20; Region: UPF0118; pfam01594 508767006244 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 508767006245 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 508767006246 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 508767006247 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767006248 Coenzyme A binding pocket [chemical binding]; other site 508767006249 arginine:agmatin antiporter; Provisional; Region: PRK10644 508767006250 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 508767006251 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 508767006252 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 508767006253 homodimer interface [polypeptide binding]; other site 508767006254 active site 508767006255 FMN binding site [chemical binding]; other site 508767006256 substrate binding site [chemical binding]; other site 508767006257 4Fe-4S binding domain; Region: Fer4; cl02805 508767006258 4Fe-4S binding domain; Region: Fer4; pfam00037 508767006259 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 508767006260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 508767006261 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508767006262 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 508767006263 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 508767006264 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508767006265 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 508767006266 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 508767006267 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 508767006268 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508767006269 ATP binding site [chemical binding]; other site 508767006270 putative Mg++ binding site [ion binding]; other site 508767006271 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508767006272 nucleotide binding region [chemical binding]; other site 508767006273 ATP-binding site [chemical binding]; other site 508767006274 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 508767006275 HSP70 interaction site [polypeptide binding]; other site 508767006276 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 508767006277 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508767006278 ATP binding site [chemical binding]; other site 508767006279 putative Mg++ binding site [ion binding]; other site 508767006280 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508767006281 nucleotide binding region [chemical binding]; other site 508767006282 ATP-binding site [chemical binding]; other site 508767006283 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 508767006284 HRDC domain; Region: HRDC; pfam00570 508767006285 HRDC domain; Region: HRDC; pfam00570 508767006286 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 508767006287 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 508767006288 active site 508767006289 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 508767006290 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 508767006291 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 508767006292 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 508767006293 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 508767006294 dimer interface [polypeptide binding]; other site 508767006295 PYR/PP interface [polypeptide binding]; other site 508767006296 TPP binding site [chemical binding]; other site 508767006297 substrate binding site [chemical binding]; other site 508767006298 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 508767006299 Domain of unknown function; Region: EKR; smart00890 508767006300 4Fe-4S binding domain; Region: Fer4_6; pfam12837 508767006301 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508767006302 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 508767006303 TPP-binding site [chemical binding]; other site 508767006304 dimer interface [polypeptide binding]; other site 508767006305 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 508767006306 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 508767006307 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 508767006308 fructuronate transporter; Provisional; Region: PRK10034; cl15264 508767006309 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 508767006310 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 508767006311 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 508767006312 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 508767006313 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508767006314 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 508767006315 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 508767006316 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 508767006317 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 508767006318 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 508767006319 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 508767006320 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508767006321 MarR family; Region: MarR_2; pfam12802 508767006322 hypothetical protein; Validated; Region: PRK02101 508767006323 hypothetical protein; Provisional; Region: PRK05802 508767006324 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 508767006325 FAD binding pocket [chemical binding]; other site 508767006326 FAD binding motif [chemical binding]; other site 508767006327 phosphate binding motif [ion binding]; other site 508767006328 beta-alpha-beta structure motif; other site 508767006329 NAD binding pocket [chemical binding]; other site 508767006330 Iron coordination center [ion binding]; other site 508767006331 Glucose inhibited division protein A; Region: GIDA; pfam01134 508767006332 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 508767006333 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 508767006334 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 508767006335 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 508767006336 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 508767006337 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 508767006338 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 508767006339 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 508767006340 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 508767006341 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 508767006342 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 508767006343 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 508767006344 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 508767006345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767006346 AAA domain; Region: AAA_21; pfam13304 508767006347 Walker A/P-loop; other site 508767006348 ATP binding site [chemical binding]; other site 508767006349 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 508767006350 Walker B; other site 508767006351 D-loop; other site 508767006352 H-loop/switch region; other site 508767006353 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 508767006354 amidase catalytic site [active] 508767006355 Zn binding residues [ion binding]; other site 508767006356 substrate binding site [chemical binding]; other site 508767006357 Holin family; Region: Phage_holin_4; pfam05105 508767006358 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 508767006359 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 508767006360 Phage-related protein [Function unknown]; Region: COG4722 508767006361 Phage tail protein; Region: Sipho_tail; cl17486 508767006362 Phage tail protein; Region: Sipho_tail; cl17486 508767006363 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 508767006364 membrane protein P6; Region: PHA01399 508767006365 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 508767006366 Phage capsid family; Region: Phage_capsid; pfam05065 508767006367 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 508767006368 oligomer interface [polypeptide binding]; other site 508767006369 active site residues [active] 508767006370 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 508767006371 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 508767006372 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 508767006373 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508767006374 active site 508767006375 DNA binding site [nucleotide binding] 508767006376 Int/Topo IB signature motif; other site 508767006377 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 508767006378 Helix-turn-helix domain; Region: HTH_36; pfam13730 508767006379 ParB-like nuclease domain; Region: ParBc; pfam02195 508767006380 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 508767006381 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 508767006382 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 508767006383 P-loop; other site 508767006384 Magnesium ion binding site [ion binding]; other site 508767006385 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 508767006386 Magnesium ion binding site [ion binding]; other site 508767006387 Helix-turn-helix domain; Region: HTH_17; pfam12728 508767006388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508767006389 salt bridge; other site 508767006390 non-specific DNA binding site [nucleotide binding]; other site 508767006391 sequence-specific DNA binding site [nucleotide binding]; other site 508767006392 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508767006393 non-specific DNA binding site [nucleotide binding]; other site 508767006394 salt bridge; other site 508767006395 sequence-specific DNA binding site [nucleotide binding]; other site 508767006396 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 508767006397 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508767006398 non-specific DNA binding site [nucleotide binding]; other site 508767006399 salt bridge; other site 508767006400 sequence-specific DNA binding site [nucleotide binding]; other site 508767006401 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 508767006402 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 508767006403 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767006404 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 508767006405 Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; cl17890 508767006406 Uncharacterized conserved protein [Function unknown]; Region: COG4933 508767006407 Domain of unknown function (DUF955); Region: DUF955; pfam06114 508767006408 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 508767006409 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 508767006410 Int/Topo IB signature motif; other site 508767006411 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508767006412 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 508767006413 active site 508767006414 DNA binding site [nucleotide binding] 508767006415 Int/Topo IB signature motif; other site 508767006416 Integral membrane protein DUF95; Region: DUF95; cl00572 508767006417 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 508767006418 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 508767006419 active site 508767006420 Na/Ca binding site [ion binding]; other site 508767006421 catalytic site [active] 508767006422 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 508767006423 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 508767006424 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 508767006425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767006426 active site 508767006427 phosphorylation site [posttranslational modification] 508767006428 intermolecular recognition site; other site 508767006429 dimerization interface [polypeptide binding]; other site 508767006430 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 508767006431 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 508767006432 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 508767006433 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 508767006434 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 508767006435 Walker A/P-loop; other site 508767006436 ATP binding site [chemical binding]; other site 508767006437 Q-loop/lid; other site 508767006438 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 508767006439 ABC transporter signature motif; other site 508767006440 Walker B; other site 508767006441 D-loop; other site 508767006442 H-loop/switch region; other site 508767006443 arginine repressor; Provisional; Region: argR; PRK00441 508767006444 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 508767006445 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 508767006446 ATP-NAD kinase; Region: NAD_kinase; pfam01513 508767006447 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 508767006448 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 508767006449 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508767006450 RNA binding surface [nucleotide binding]; other site 508767006451 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 508767006452 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 508767006453 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 508767006454 TPP-binding site; other site 508767006455 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 508767006456 PYR/PP interface [polypeptide binding]; other site 508767006457 dimer interface [polypeptide binding]; other site 508767006458 TPP binding site [chemical binding]; other site 508767006459 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 508767006460 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 508767006461 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 508767006462 substrate binding pocket [chemical binding]; other site 508767006463 chain length determination region; other site 508767006464 substrate-Mg2+ binding site; other site 508767006465 catalytic residues [active] 508767006466 aspartate-rich region 1; other site 508767006467 active site lid residues [active] 508767006468 aspartate-rich region 2; other site 508767006469 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 508767006470 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 508767006471 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 508767006472 generic binding surface II; other site 508767006473 generic binding surface I; other site 508767006474 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14172 508767006475 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 508767006476 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 508767006477 homodimer interface [polypeptide binding]; other site 508767006478 NADP binding site [chemical binding]; other site 508767006479 substrate binding site [chemical binding]; other site 508767006480 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 508767006481 putative RNA binding site [nucleotide binding]; other site 508767006482 Asp23 family; Region: Asp23; pfam03780 508767006483 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 508767006484 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 508767006485 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 508767006486 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 508767006487 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 508767006488 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 508767006489 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 508767006490 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 508767006491 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 508767006492 Walker A motif; other site 508767006493 ATP binding site [chemical binding]; other site 508767006494 elongation factor P; Validated; Region: PRK00529 508767006495 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 508767006496 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 508767006497 RNA binding site [nucleotide binding]; other site 508767006498 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 508767006499 RNA binding site [nucleotide binding]; other site 508767006500 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 508767006501 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 508767006502 Type II/IV secretion system protein; Region: T2SE; pfam00437 508767006503 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 508767006504 Walker A motif; other site 508767006505 ATP binding site [chemical binding]; other site 508767006506 Walker B motif; other site 508767006507 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 508767006508 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 508767006509 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 508767006510 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 508767006511 Domain of unknown function (DUF814); Region: DUF814; pfam05670 508767006512 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 508767006513 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 508767006514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 508767006515 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 508767006516 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508767006517 active site 508767006518 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 508767006519 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508767006520 RNA binding surface [nucleotide binding]; other site 508767006521 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 508767006522 active site 508767006523 DivIVA protein; Region: DivIVA; pfam05103 508767006524 DivIVA domain; Region: DivI1A_domain; TIGR03544 508767006525 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 508767006526 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508767006527 RNA binding surface [nucleotide binding]; other site 508767006528 YGGT family; Region: YGGT; pfam02325 508767006529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 508767006530 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 508767006531 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 508767006532 catalytic residue [active] 508767006533 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 508767006534 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 508767006535 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 508767006536 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 508767006537 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 508767006538 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 508767006539 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 508767006540 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 508767006541 Mg++ binding site [ion binding]; other site 508767006542 putative catalytic motif [active] 508767006543 putative substrate binding site [chemical binding]; other site 508767006544 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 508767006545 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 508767006546 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508767006547 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 508767006548 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 508767006549 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 508767006550 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508767006551 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 508767006552 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 508767006553 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 508767006554 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 508767006555 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 508767006556 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 508767006557 MraW methylase family; Region: Methyltransf_5; pfam01795 508767006558 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 508767006559 cell division protein MraZ; Reviewed; Region: PRK00326 508767006560 MraZ protein; Region: MraZ; pfam02381 508767006561 MraZ protein; Region: MraZ; pfam02381 508767006562 AzlC protein; Region: AzlC; pfam03591 508767006563 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 508767006564 Integral membrane protein TerC family; Region: TerC; cl10468 508767006565 GTP-binding protein YchF; Reviewed; Region: PRK09601 508767006566 YchF GTPase; Region: YchF; cd01900 508767006567 G1 box; other site 508767006568 GTP/Mg2+ binding site [chemical binding]; other site 508767006569 Switch I region; other site 508767006570 G2 box; other site 508767006571 Switch II region; other site 508767006572 G3 box; other site 508767006573 G4 box; other site 508767006574 G5 box; other site 508767006575 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 508767006576 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 508767006577 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 508767006578 NodB motif; other site 508767006579 active site 508767006580 catalytic site [active] 508767006581 Cd binding site [ion binding]; other site 508767006582 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 508767006583 O-Antigen ligase; Region: Wzy_C; pfam04932 508767006584 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 508767006585 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 508767006586 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 508767006587 integral membrane protein MviN; Region: mviN; TIGR01695 508767006588 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 508767006589 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 508767006590 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 508767006591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508767006592 binding surface 508767006593 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508767006594 TPR motif; other site 508767006595 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508767006596 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 508767006597 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 508767006598 active site 508767006599 substrate binding site [chemical binding]; other site 508767006600 metal binding site [ion binding]; metal-binding site 508767006601 Protein of unknown function (DUF523); Region: DUF523; pfam04463 508767006602 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 508767006603 MutS domain III; Region: MutS_III; pfam05192 508767006604 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767006605 Walker A/P-loop; other site 508767006606 ATP binding site [chemical binding]; other site 508767006607 Q-loop/lid; other site 508767006608 ABC transporter signature motif; other site 508767006609 Walker B; other site 508767006610 D-loop; other site 508767006611 H-loop/switch region; other site 508767006612 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 508767006613 Smr domain; Region: Smr; pfam01713 508767006614 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 508767006615 Peptidase family U32; Region: Peptidase_U32; pfam01136 508767006616 Collagenase; Region: DUF3656; pfam12392 508767006617 Peptidase family U32; Region: Peptidase_U32; cl03113 508767006618 Cell division protein ZapA; Region: ZapA; pfam05164 508767006619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508767006620 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508767006621 putative substrate translocation pore; other site 508767006622 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508767006623 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508767006624 metal binding site [ion binding]; metal-binding site 508767006625 active site 508767006626 I-site; other site 508767006627 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508767006628 metal binding site [ion binding]; metal-binding site 508767006629 active site 508767006630 I-site; other site 508767006631 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 508767006632 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 508767006633 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 508767006634 Mechanosensitive ion channel; Region: MS_channel; pfam00924 508767006635 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 508767006636 dimer interface [polypeptide binding]; other site 508767006637 catalytic triad [active] 508767006638 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 508767006639 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 508767006640 putative tRNA-binding site [nucleotide binding]; other site 508767006641 B3/4 domain; Region: B3_4; pfam03483 508767006642 tRNA synthetase B5 domain; Region: B5; smart00874 508767006643 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 508767006644 dimer interface [polypeptide binding]; other site 508767006645 motif 1; other site 508767006646 motif 3; other site 508767006647 motif 2; other site 508767006648 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 508767006649 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 508767006650 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 508767006651 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 508767006652 dimer interface [polypeptide binding]; other site 508767006653 motif 1; other site 508767006654 active site 508767006655 motif 2; other site 508767006656 motif 3; other site 508767006657 T-box leader 508767006658 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 508767006659 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 508767006660 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 508767006661 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 508767006662 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 508767006663 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 508767006664 TrkA-N domain; Region: TrkA_N; pfam02254 508767006665 TrkA-C domain; Region: TrkA_C; pfam02080 508767006666 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 508767006667 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 508767006668 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 508767006669 23S rRNA binding site [nucleotide binding]; other site 508767006670 L21 binding site [polypeptide binding]; other site 508767006671 L13 binding site [polypeptide binding]; other site 508767006672 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 508767006673 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 508767006674 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 508767006675 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 508767006676 Ribosomal protein L20 leader 508767006677 YtxC-like family; Region: YtxC; cl08500 508767006678 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 508767006679 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 508767006680 dimerization interface [polypeptide binding]; other site 508767006681 domain crossover interface; other site 508767006682 redox-dependent activation switch; other site 508767006683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767006684 S-adenosylmethionine binding site [chemical binding]; other site 508767006685 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 508767006686 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 508767006687 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 508767006688 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 508767006689 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 508767006690 dihydrodipicolinate synthase; Region: dapA; TIGR00674 508767006691 dimer interface [polypeptide binding]; other site 508767006692 active site 508767006693 catalytic residue [active] 508767006694 dihydrodipicolinate reductase; Provisional; Region: PRK00048 508767006695 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 508767006696 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 508767006697 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 508767006698 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 508767006699 peptide binding site [polypeptide binding]; other site 508767006700 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 508767006701 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 508767006702 Walker A/P-loop; other site 508767006703 ATP binding site [chemical binding]; other site 508767006704 Q-loop/lid; other site 508767006705 ABC transporter signature motif; other site 508767006706 Walker B; other site 508767006707 D-loop; other site 508767006708 H-loop/switch region; other site 508767006709 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 508767006710 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 508767006711 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 508767006712 Walker A/P-loop; other site 508767006713 ATP binding site [chemical binding]; other site 508767006714 Q-loop/lid; other site 508767006715 ABC transporter signature motif; other site 508767006716 Walker B; other site 508767006717 D-loop; other site 508767006718 H-loop/switch region; other site 508767006719 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 508767006720 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 508767006721 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 508767006722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767006723 dimer interface [polypeptide binding]; other site 508767006724 conserved gate region; other site 508767006725 putative PBP binding loops; other site 508767006726 ABC-ATPase subunit interface; other site 508767006727 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 508767006728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767006729 dimer interface [polypeptide binding]; other site 508767006730 conserved gate region; other site 508767006731 putative PBP binding loops; other site 508767006732 ABC-ATPase subunit interface; other site 508767006733 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 508767006734 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 508767006735 peptide binding site [polypeptide binding]; other site 508767006736 aminotransferase A; Validated; Region: PRK07683 508767006737 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508767006738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767006739 homodimer interface [polypeptide binding]; other site 508767006740 catalytic residue [active] 508767006741 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 508767006742 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 508767006743 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 508767006744 active site 508767006745 trimer interface [polypeptide binding]; other site 508767006746 substrate binding site [chemical binding]; other site 508767006747 CoA binding site [chemical binding]; other site 508767006748 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 508767006749 putative CoA binding site [chemical binding]; other site 508767006750 putative trimer interface [polypeptide binding]; other site 508767006751 single-stranded DNA-binding protein; Provisional; Region: PRK05813 508767006752 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 508767006753 dimer interface [polypeptide binding]; other site 508767006754 ssDNA binding site [nucleotide binding]; other site 508767006755 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508767006756 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 508767006757 NodB motif; other site 508767006758 active site 508767006759 catalytic site [active] 508767006760 metal binding site [ion binding]; metal-binding site 508767006761 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 508767006762 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 508767006763 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 508767006764 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 508767006765 TSCPD domain; Region: TSCPD; cl14834 508767006766 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 508767006767 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 508767006768 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 508767006769 hypothetical protein; Provisional; Region: PRK01119 508767006770 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 508767006771 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 508767006772 active site 508767006773 HIGH motif; other site 508767006774 nucleotide binding site [chemical binding]; other site 508767006775 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 508767006776 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 508767006777 active site 508767006778 KMSKS motif; other site 508767006779 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 508767006780 tRNA binding surface [nucleotide binding]; other site 508767006781 anticodon binding site; other site 508767006782 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 508767006783 T-box leader 508767006784 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 508767006785 putative dimer interface [polypeptide binding]; other site 508767006786 catalytic triad [active] 508767006787 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 508767006788 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 508767006789 Ligand binding site; other site 508767006790 Putative Catalytic site; other site 508767006791 DXD motif; other site 508767006792 Predicted membrane protein [Function unknown]; Region: COG2246 508767006793 GtrA-like protein; Region: GtrA; pfam04138 508767006794 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 508767006795 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 508767006796 dimer interface [polypeptide binding]; other site 508767006797 active site 508767006798 metal binding site [ion binding]; metal-binding site 508767006799 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 508767006800 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 508767006801 RNA binding surface [nucleotide binding]; other site 508767006802 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 508767006803 probable active site [active] 508767006804 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 508767006805 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 508767006806 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767006807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767006808 dimer interface [polypeptide binding]; other site 508767006809 phosphorylation site [posttranslational modification] 508767006810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767006811 ATP binding site [chemical binding]; other site 508767006812 Mg2+ binding site [ion binding]; other site 508767006813 G-X-G motif; other site 508767006814 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 508767006815 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508767006816 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 508767006817 Domain of unknown function DUF11; Region: DUF11; cl17728 508767006818 Domain of unknown function DUF11; Region: DUF11; cl17728 508767006819 Domain of unknown function DUF11; Region: DUF11; cl17728 508767006820 Domain of unknown function DUF11; Region: DUF11; cl17728 508767006821 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508767006822 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508767006823 Domain of unknown function DUF11; Region: DUF11; cl17728 508767006824 Domain of unknown function DUF11; Region: DUF11; cl17728 508767006825 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508767006826 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508767006827 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508767006828 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508767006829 Domain of unknown function DUF11; Region: DUF11; cl17728 508767006830 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508767006831 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508767006832 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508767006833 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 508767006834 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 508767006835 MATE family multidrug exporter; Provisional; Region: PRK10189 508767006836 Helix-turn-helix domain; Region: HTH_17; cl17695 508767006837 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 508767006838 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 508767006839 ligand binding site [chemical binding]; other site 508767006840 calcium binding site [ion binding]; other site 508767006841 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 508767006842 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 508767006843 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 508767006844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 508767006845 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 508767006846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 508767006847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508767006848 binding surface 508767006849 TPR motif; other site 508767006850 TPR repeat; Region: TPR_11; pfam13414 508767006851 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 508767006852 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 508767006853 RecX family; Region: RecX; cl00936 508767006854 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 508767006855 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 508767006856 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 508767006857 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767006858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767006859 active site 508767006860 phosphorylation site [posttranslational modification] 508767006861 intermolecular recognition site; other site 508767006862 dimerization interface [polypeptide binding]; other site 508767006863 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767006864 DNA binding site [nucleotide binding] 508767006865 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767006866 dimerization interface [polypeptide binding]; other site 508767006867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767006868 dimer interface [polypeptide binding]; other site 508767006869 phosphorylation site [posttranslational modification] 508767006870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767006871 ATP binding site [chemical binding]; other site 508767006872 Mg2+ binding site [ion binding]; other site 508767006873 G-X-G motif; other site 508767006874 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 508767006875 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 508767006876 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 508767006877 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 508767006878 catalytic residues [active] 508767006879 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508767006880 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 508767006881 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 508767006882 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 508767006883 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 508767006884 Walker A/P-loop; other site 508767006885 ATP binding site [chemical binding]; other site 508767006886 Q-loop/lid; other site 508767006887 ABC transporter signature motif; other site 508767006888 Walker B; other site 508767006889 D-loop; other site 508767006890 H-loop/switch region; other site 508767006891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767006892 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508767006893 Walker A/P-loop; other site 508767006894 ATP binding site [chemical binding]; other site 508767006895 Q-loop/lid; other site 508767006896 ABC transporter signature motif; other site 508767006897 Walker B; other site 508767006898 D-loop; other site 508767006899 H-loop/switch region; other site 508767006900 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 508767006901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 508767006902 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 508767006903 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 508767006904 Protein of unknown function (DUF327); Region: DUF327; pfam03885 508767006905 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 508767006906 active site 508767006907 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 508767006908 dimer interface [polypeptide binding]; other site 508767006909 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 508767006910 Ligand Binding Site [chemical binding]; other site 508767006911 Molecular Tunnel; other site 508767006912 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 508767006913 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 508767006914 S1 domain; Region: S1_2; pfam13509 508767006915 S1 domain; Region: S1_2; pfam13509 508767006916 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 508767006917 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 508767006918 trimer interface [polypeptide binding]; other site 508767006919 putative metal binding site [ion binding]; other site 508767006920 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 508767006921 AsnC family; Region: AsnC_trans_reg; pfam01037 508767006922 Uncharacterized conserved protein [Function unknown]; Region: COG2155 508767006923 Predicted membrane protein [Function unknown]; Region: COG4905 508767006924 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 508767006925 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 508767006926 active site 508767006927 metal-binding site [ion binding] 508767006928 nucleotide-binding site [chemical binding]; other site 508767006929 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 508767006930 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 508767006931 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 508767006932 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 508767006933 active site 508767006934 HIGH motif; other site 508767006935 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 508767006936 active site 508767006937 KMSKS motif; other site 508767006938 RNase_H superfamily; Region: RNase_H_2; pfam13482 508767006939 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 508767006940 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767006941 motif II; other site 508767006942 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 508767006943 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 508767006944 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 508767006945 G1 box; other site 508767006946 GTP/Mg2+ binding site [chemical binding]; other site 508767006947 Switch I region; other site 508767006948 G2 box; other site 508767006949 G3 box; other site 508767006950 Switch II region; other site 508767006951 G4 box; other site 508767006952 G5 box; other site 508767006953 Nucleoside recognition; Region: Gate; pfam07670 508767006954 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 508767006955 Nucleoside recognition; Region: Gate; pfam07670 508767006956 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 508767006957 Domain of unknown function DUF20; Region: UPF0118; pfam01594 508767006958 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 508767006959 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 508767006960 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 508767006961 active site 508767006962 HIGH motif; other site 508767006963 KMSK motif region; other site 508767006964 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 508767006965 tRNA binding surface [nucleotide binding]; other site 508767006966 anticodon binding site; other site 508767006967 T-box leader 508767006968 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 508767006969 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 508767006970 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 508767006971 Peptidase family M50; Region: Peptidase_M50; pfam02163 508767006972 active site 508767006973 putative substrate binding region [chemical binding]; other site 508767006974 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 508767006975 Biotin operon repressor [Transcription]; Region: BirA; COG1654 508767006976 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 508767006977 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 508767006978 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 508767006979 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 508767006980 dimer interface [polypeptide binding]; other site 508767006981 active site 508767006982 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 508767006983 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 508767006984 NAD binding site [chemical binding]; other site 508767006985 dimer interface [polypeptide binding]; other site 508767006986 substrate binding site [chemical binding]; other site 508767006987 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508767006988 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 508767006989 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 508767006990 active site 508767006991 catalytic site [active] 508767006992 substrate binding site [chemical binding]; other site 508767006993 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 508767006994 Rubredoxin; Region: Rubredoxin; pfam00301 508767006995 iron binding site [ion binding]; other site 508767006996 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 508767006997 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767006998 FeS/SAM binding site; other site 508767006999 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 508767007000 Pyruvate formate lyase 1; Region: PFL1; cd01678 508767007001 coenzyme A binding site [chemical binding]; other site 508767007002 active site 508767007003 catalytic residues [active] 508767007004 glycine loop; other site 508767007005 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 508767007006 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 508767007007 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 508767007008 NodB motif; other site 508767007009 putative active site [active] 508767007010 putative catalytic site [active] 508767007011 putative Zn binding site [ion binding]; other site 508767007012 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508767007013 active site 508767007014 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 508767007015 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 508767007016 heterodimer interface [polypeptide binding]; other site 508767007017 active site 508767007018 FMN binding site [chemical binding]; other site 508767007019 homodimer interface [polypeptide binding]; other site 508767007020 substrate binding site [chemical binding]; other site 508767007021 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 508767007022 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 508767007023 FAD binding pocket [chemical binding]; other site 508767007024 FAD binding motif [chemical binding]; other site 508767007025 phosphate binding motif [ion binding]; other site 508767007026 beta-alpha-beta structure motif; other site 508767007027 NAD binding pocket [chemical binding]; other site 508767007028 Iron coordination center [ion binding]; other site 508767007029 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 508767007030 active site 508767007031 dimer interface [polypeptide binding]; other site 508767007032 dihydroorotase; Validated; Region: pyrC; PRK09357 508767007033 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 508767007034 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 508767007035 active site 508767007036 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 508767007037 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 508767007038 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 508767007039 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 508767007040 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 508767007041 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 508767007042 PyrR binding site 508767007043 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 508767007044 TPR repeat; Region: TPR_11; pfam13414 508767007045 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508767007046 binding surface 508767007047 TPR motif; other site 508767007048 TPR repeat; Region: TPR_11; pfam13414 508767007049 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 508767007050 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508767007051 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 508767007052 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 508767007053 catalytic triad [active] 508767007054 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 508767007055 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 508767007056 NodB motif; other site 508767007057 active site 508767007058 catalytic site [active] 508767007059 Zn binding site [ion binding]; other site 508767007060 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 508767007061 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 508767007062 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 508767007063 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 508767007064 ArsC family; Region: ArsC; pfam03960 508767007065 catalytic residue [active] 508767007066 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 508767007067 Acyltransferase family; Region: Acyl_transf_3; pfam01757 508767007068 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 508767007069 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 508767007070 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508767007071 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 508767007072 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767007073 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767007074 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 508767007075 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 508767007076 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767007077 dimerization interface [polypeptide binding]; other site 508767007078 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767007079 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767007080 dimer interface [polypeptide binding]; other site 508767007081 putative CheW interface [polypeptide binding]; other site 508767007082 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767007083 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767007084 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 508767007085 trimer interface [polypeptide binding]; other site 508767007086 active site 508767007087 substrate binding site [chemical binding]; other site 508767007088 CoA binding site [chemical binding]; other site 508767007089 T-box leader 508767007090 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 508767007091 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 508767007092 Clostridium thermocellum (Cth)TTM and similar proteins, a subgroup of the CYTH-like superfamily; Region: CYTH-like_CthTTM-like; cd07761 508767007093 putative active site [active] 508767007094 putative metal binding residues [ion binding]; other site 508767007095 signature motif; other site 508767007096 putative dimer interface [polypeptide binding]; other site 508767007097 putative phosphate binding site [ion binding]; other site 508767007098 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 508767007099 active site 508767007100 NTP binding site [chemical binding]; other site 508767007101 metal binding triad [ion binding]; metal-binding site 508767007102 Fic/DOC family; Region: Fic; pfam02661 508767007103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767007104 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 508767007105 Coenzyme A binding pocket [chemical binding]; other site 508767007106 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 508767007107 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 508767007108 active site 508767007109 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 508767007110 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 508767007111 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 508767007112 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 508767007113 NMT1-like family; Region: NMT1_2; pfam13379 508767007114 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 508767007115 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 508767007116 Walker A/P-loop; other site 508767007117 ATP binding site [chemical binding]; other site 508767007118 Q-loop/lid; other site 508767007119 ABC transporter signature motif; other site 508767007120 Walker B; other site 508767007121 D-loop; other site 508767007122 H-loop/switch region; other site 508767007123 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 508767007124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767007125 dimer interface [polypeptide binding]; other site 508767007126 conserved gate region; other site 508767007127 putative PBP binding loops; other site 508767007128 ABC-ATPase subunit interface; other site 508767007129 LrgA family; Region: LrgA; pfam03788 508767007130 LrgB-like family; Region: LrgB; pfam04172 508767007131 DNA topoisomerase III; Provisional; Region: PRK07726 508767007132 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 508767007133 active site 508767007134 putative interdomain interaction site [polypeptide binding]; other site 508767007135 putative metal-binding site [ion binding]; other site 508767007136 putative nucleotide binding site [chemical binding]; other site 508767007137 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 508767007138 domain I; other site 508767007139 DNA binding groove [nucleotide binding] 508767007140 phosphate binding site [ion binding]; other site 508767007141 domain II; other site 508767007142 domain III; other site 508767007143 nucleotide binding site [chemical binding]; other site 508767007144 catalytic site [active] 508767007145 domain IV; other site 508767007146 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 508767007147 TspO/MBR family; Region: TspO_MBR; pfam03073 508767007148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767007149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767007150 dimer interface [polypeptide binding]; other site 508767007151 phosphorylation site [posttranslational modification] 508767007152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767007153 ATP binding site [chemical binding]; other site 508767007154 Mg2+ binding site [ion binding]; other site 508767007155 G-X-G motif; other site 508767007156 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767007157 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767007158 dimer interface [polypeptide binding]; other site 508767007159 phosphorylation site [posttranslational modification] 508767007160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767007161 ATP binding site [chemical binding]; other site 508767007162 Mg2+ binding site [ion binding]; other site 508767007163 G-X-G motif; other site 508767007164 Predicted membrane protein [Function unknown]; Region: COG1511 508767007165 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 508767007166 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 508767007167 Predicted membrane protein [Function unknown]; Region: COG1511 508767007168 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 508767007169 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 508767007170 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 508767007171 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 508767007172 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 508767007173 N-acetyl-D-glucosamine binding site [chemical binding]; other site 508767007174 catalytic residue [active] 508767007175 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 508767007176 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 508767007177 CoA-binding site [chemical binding]; other site 508767007178 DNA polymerase I; Provisional; Region: PRK05755 508767007179 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 508767007180 active site 508767007181 metal binding site 1 [ion binding]; metal-binding site 508767007182 putative 5' ssDNA interaction site; other site 508767007183 metal binding site 3; metal-binding site 508767007184 metal binding site 2 [ion binding]; metal-binding site 508767007185 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 508767007186 putative DNA binding site [nucleotide binding]; other site 508767007187 putative metal binding site [ion binding]; other site 508767007188 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 508767007189 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 508767007190 active site 508767007191 DNA binding site [nucleotide binding] 508767007192 catalytic site [active] 508767007193 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 508767007194 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 508767007195 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 508767007196 trimer interface [polypeptide binding]; other site 508767007197 active site 508767007198 isocitrate dehydrogenase; Validated; Region: PRK08299 508767007199 Predicted membrane protein [Function unknown]; Region: COG2855 508767007200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 508767007201 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 508767007202 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 508767007203 putative dimerization interface [polypeptide binding]; other site 508767007204 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 508767007205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 508767007206 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 508767007207 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 508767007208 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 508767007209 P loop; other site 508767007210 Nucleotide binding site [chemical binding]; other site 508767007211 DTAP/Switch II; other site 508767007212 Switch I; other site 508767007213 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 508767007214 P loop; other site 508767007215 Nucleotide binding site [chemical binding]; other site 508767007216 DTAP/Switch II; other site 508767007217 Switch I; other site 508767007218 repressor of silencing 3; Provisional; Region: PLN03213 508767007219 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 508767007220 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767007221 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767007222 dimer interface [polypeptide binding]; other site 508767007223 putative CheW interface [polypeptide binding]; other site 508767007224 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 508767007225 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 508767007226 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 508767007227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767007228 dimer interface [polypeptide binding]; other site 508767007229 conserved gate region; other site 508767007230 putative PBP binding loops; other site 508767007231 ABC-ATPase subunit interface; other site 508767007232 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 508767007233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767007234 dimer interface [polypeptide binding]; other site 508767007235 conserved gate region; other site 508767007236 putative PBP binding loops; other site 508767007237 ABC-ATPase subunit interface; other site 508767007238 Ion channel; Region: Ion_trans_2; pfam07885 508767007239 A new structural DNA glycosylase; Region: AlkD_like; cd06561 508767007240 active site 508767007241 Cache domain; Region: Cache_1; pfam02743 508767007242 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767007243 dimerization interface [polypeptide binding]; other site 508767007244 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767007245 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767007246 dimer interface [polypeptide binding]; other site 508767007247 putative CheW interface [polypeptide binding]; other site 508767007248 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 508767007249 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767007250 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767007251 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767007252 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767007253 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767007254 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 508767007255 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 508767007256 active site 508767007257 metal binding site [ion binding]; metal-binding site 508767007258 PilZ domain; Region: PilZ; pfam07238 508767007259 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 508767007260 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508767007261 Predicted membrane protein [Function unknown]; Region: COG2364 508767007262 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508767007263 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 508767007264 Transcriptional regulators [Transcription]; Region: MarR; COG1846 508767007265 MarR family; Region: MarR; pfam01047 508767007266 MarR family; Region: MarR_2; cl17246 508767007267 YvrJ protein family; Region: YvrJ; pfam12841 508767007268 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 508767007269 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 508767007270 putative active site [active] 508767007271 Probable transposase; Region: OrfB_IS605; pfam01385 508767007272 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 508767007273 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 508767007274 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 508767007275 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 508767007276 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 508767007277 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 508767007278 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508767007279 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508767007280 DNA binding residues [nucleotide binding] 508767007281 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 508767007282 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 508767007283 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 508767007284 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 508767007285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767007286 S-adenosylmethionine binding site [chemical binding]; other site 508767007287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767007288 S-adenosylmethionine binding site [chemical binding]; other site 508767007289 TfoX N-terminal domain; Region: TfoX_N; pfam04993 508767007290 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 508767007291 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 508767007292 active site 508767007293 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 508767007294 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 508767007295 nudix motif; other site 508767007296 TfoX C-terminal domain; Region: TfoX_C; pfam04994 508767007297 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 508767007298 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 508767007299 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 508767007300 GAD-like domain; Region: GAD-like; pfam08887 508767007301 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 508767007302 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 508767007303 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 508767007304 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 508767007305 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508767007306 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767007307 Coenzyme A binding pocket [chemical binding]; other site 508767007308 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 508767007309 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767007310 HAMP domain; Region: HAMP; pfam00672 508767007311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767007312 dimer interface [polypeptide binding]; other site 508767007313 phosphorylation site [posttranslational modification] 508767007314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767007315 ATP binding site [chemical binding]; other site 508767007316 Mg2+ binding site [ion binding]; other site 508767007317 G-X-G motif; other site 508767007318 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767007319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767007320 active site 508767007321 phosphorylation site [posttranslational modification] 508767007322 intermolecular recognition site; other site 508767007323 dimerization interface [polypeptide binding]; other site 508767007324 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767007325 DNA binding site [nucleotide binding] 508767007326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767007327 S-adenosylmethionine binding site [chemical binding]; other site 508767007328 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 508767007329 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 508767007330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508767007331 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508767007332 DNA binding residues [nucleotide binding] 508767007333 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 508767007334 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 508767007335 active site 508767007336 FMN binding site [chemical binding]; other site 508767007337 substrate binding site [chemical binding]; other site 508767007338 putative catalytic residue [active] 508767007339 Predicted transcriptional regulators [Transcription]; Region: COG1733 508767007340 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 508767007341 Chloramphenicol acetyltransferase; Region: CAT; cl02008 508767007342 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 508767007343 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 508767007344 active site 508767007345 NTP binding site [chemical binding]; other site 508767007346 metal binding triad [ion binding]; metal-binding site 508767007347 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 508767007348 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 508767007349 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 508767007350 catalytic residues [active] 508767007351 catalytic nucleophile [active] 508767007352 Recombinase; Region: Recombinase; pfam07508 508767007353 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 508767007354 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 508767007355 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 508767007356 cofactor binding site; other site 508767007357 DNA binding site [nucleotide binding] 508767007358 substrate interaction site [chemical binding]; other site 508767007359 HindVP restriction endonuclease; Region: RE_HindVP; pfam09519 508767007360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 508767007361 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 508767007362 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 508767007363 active site 508767007364 catalytic residues [active] 508767007365 metal binding site [ion binding]; metal-binding site 508767007366 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 508767007367 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 508767007368 Predicted transcriptional regulators [Transcription]; Region: COG1695 508767007369 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 508767007370 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 508767007371 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 508767007372 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 508767007373 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 508767007374 Beta-lactamase; Region: Beta-lactamase; pfam00144 508767007375 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 508767007376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767007377 Coenzyme A binding pocket [chemical binding]; other site 508767007378 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 508767007379 Amidinotransferase; Region: Amidinotransf; cl12043 508767007380 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 508767007381 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 508767007382 Prophage antirepressor [Transcription]; Region: COG3617 508767007383 BRO family, N-terminal domain; Region: Bro-N; smart01040 508767007384 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 508767007385 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 508767007386 non-specific DNA binding site [nucleotide binding]; other site 508767007387 salt bridge; other site 508767007388 sequence-specific DNA binding site [nucleotide binding]; other site 508767007389 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 508767007390 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508767007391 non-specific DNA binding site [nucleotide binding]; other site 508767007392 salt bridge; other site 508767007393 sequence-specific DNA binding site [nucleotide binding]; other site 508767007394 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 508767007395 Domain of unknown function (DUF955); Region: DUF955; pfam06114 508767007396 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 508767007397 Uncharacterized conserved protein [Function unknown]; Region: COG1633 508767007398 dimanganese center [ion binding]; other site 508767007399 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767007400 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 508767007401 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 508767007402 Restriction endonuclease; Region: Mrr_cat; pfam04471 508767007403 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 508767007404 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 508767007405 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 508767007406 GGGtGRT protein; Region: GGGtGRT; pfam14057 508767007407 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 508767007408 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 508767007409 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 508767007410 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 508767007411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 508767007412 hypothetical protein; Provisional; Region: PRK13663 508767007413 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 508767007414 putative active site [active] 508767007415 putative metal binding site [ion binding]; other site 508767007416 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 508767007417 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 508767007418 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 508767007419 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 508767007420 catalytic residues [active] 508767007421 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 508767007422 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 508767007423 catalytic residues [active] 508767007424 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 508767007425 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 508767007426 4Fe-4S binding domain; Region: Fer4_5; pfam12801 508767007427 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 508767007428 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 508767007429 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 508767007430 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 508767007431 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 508767007432 EcsC protein family; Region: EcsC; pfam12787 508767007433 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 508767007434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767007435 Coenzyme A binding pocket [chemical binding]; other site 508767007436 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 508767007437 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 508767007438 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 508767007439 Catalytic site [active] 508767007440 myosin-cross-reactive antigen; Provisional; Region: PRK13977 508767007441 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 508767007442 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 508767007443 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 508767007444 FtsX-like permease family; Region: FtsX; pfam02687 508767007445 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508767007446 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 508767007447 Walker A/P-loop; other site 508767007448 ATP binding site [chemical binding]; other site 508767007449 Q-loop/lid; other site 508767007450 ABC transporter signature motif; other site 508767007451 Walker B; other site 508767007452 D-loop; other site 508767007453 H-loop/switch region; other site 508767007454 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 508767007455 HlyD family secretion protein; Region: HlyD_3; pfam13437 508767007456 BioY family; Region: BioY; pfam02632 508767007457 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 508767007458 Rubredoxin; Region: Rubredoxin; pfam00301 508767007459 iron binding site [ion binding]; other site 508767007460 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 508767007461 Rubrerythrin [Energy production and conversion]; Region: COG1592 508767007462 diiron binding motif [ion binding]; other site 508767007463 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 508767007464 Rubredoxin; Region: Rubredoxin; pfam00301 508767007465 iron binding site [ion binding]; other site 508767007466 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 508767007467 Rubrerythrin [Energy production and conversion]; Region: COG1592 508767007468 diiron binding motif [ion binding]; other site 508767007469 Cache domain; Region: Cache_1; pfam02743 508767007470 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 508767007471 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767007472 dimer interface [polypeptide binding]; other site 508767007473 putative CheW interface [polypeptide binding]; other site 508767007474 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 508767007475 active site 508767007476 domain interfaces; other site 508767007477 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 508767007478 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 508767007479 active site 508767007480 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 508767007481 Bacteriophage holin; Region: Phage_holin_1; cl02344 508767007482 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 508767007483 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 508767007484 oligomer interface [polypeptide binding]; other site 508767007485 putative active site [active] 508767007486 metal binding site [ion binding]; metal-binding site 508767007487 HPr kinase/phosphorylase; Provisional; Region: PRK05428 508767007488 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 508767007489 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 508767007490 Hpr binding site; other site 508767007491 active site 508767007492 homohexamer subunit interaction site [polypeptide binding]; other site 508767007493 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 508767007494 hypothetical protein; Provisional; Region: PRK13678 508767007495 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 508767007496 Part of AAA domain; Region: AAA_19; pfam13245 508767007497 Family description; Region: UvrD_C_2; pfam13538 508767007498 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 508767007499 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 508767007500 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 508767007501 substrate binding pocket [chemical binding]; other site 508767007502 dimer interface [polypeptide binding]; other site 508767007503 inhibitor binding site; inhibition site 508767007504 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 508767007505 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 508767007506 B12 binding site [chemical binding]; other site 508767007507 cobalt ligand [ion binding]; other site 508767007508 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 508767007509 S-ribosylhomocysteinase; Provisional; Region: PRK02260 508767007510 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 508767007511 FAD binding site [chemical binding]; other site 508767007512 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 508767007513 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 508767007514 Mg++ binding site [ion binding]; other site 508767007515 putative catalytic motif [active] 508767007516 substrate binding site [chemical binding]; other site 508767007517 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 508767007518 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 508767007519 putative active site [active] 508767007520 putative metal binding site [ion binding]; other site 508767007521 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 508767007522 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 508767007523 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 508767007524 V-type ATP synthase subunit B; Provisional; Region: PRK04196 508767007525 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 508767007526 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 508767007527 Walker A motif homologous position; other site 508767007528 Walker B motif; other site 508767007529 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 508767007530 V-type ATP synthase subunit A; Provisional; Region: PRK04192 508767007531 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 508767007532 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 508767007533 Walker A motif/ATP binding site; other site 508767007534 Walker B motif; other site 508767007535 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 508767007536 V-type ATP synthase subunit F; Provisional; Region: PRK01395 508767007537 V-type ATP synthase subunit C; Provisional; Region: PRK01198 508767007538 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 508767007539 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 508767007540 V-type ATP synthase subunit K; Validated; Region: PRK06558 508767007541 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 508767007542 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 508767007543 V-type ATP synthase subunit I; Validated; Region: PRK05771 508767007544 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 508767007545 B12 binding domain; Region: B12-binding; pfam02310 508767007546 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 508767007547 B12 binding site [chemical binding]; other site 508767007548 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767007549 FeS/SAM binding site; other site 508767007550 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 508767007551 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 508767007552 stage V sporulation protein B; Region: spore_V_B; TIGR02900 508767007553 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 508767007554 stage V sporulation protein B; Region: spore_V_B; TIGR02900 508767007555 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 508767007556 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 508767007557 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 508767007558 active site 508767007559 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 508767007560 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 508767007561 metal binding site [ion binding]; metal-binding site 508767007562 dimer interface [polypeptide binding]; other site 508767007563 cell division protein FtsA; Region: ftsA; TIGR01174 508767007564 Cell division protein FtsA; Region: FtsA; smart00842 508767007565 Cell division protein FtsA; Region: FtsA; pfam14450 508767007566 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 508767007567 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508767007568 ATP binding site [chemical binding]; other site 508767007569 Family description; Region: UvrD_C_2; pfam13538 508767007570 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 508767007571 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 508767007572 active site 508767007573 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 508767007574 metal binding site 2 [ion binding]; metal-binding site 508767007575 putative DNA binding helix; other site 508767007576 metal binding site 1 [ion binding]; metal-binding site 508767007577 dimer interface [polypeptide binding]; other site 508767007578 structural Zn2+ binding site [ion binding]; other site 508767007579 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 508767007580 G1 box; other site 508767007581 GTP/Mg2+ binding site [chemical binding]; other site 508767007582 Switch I region; other site 508767007583 G2 box; other site 508767007584 G3 box; other site 508767007585 Switch II region; other site 508767007586 G4 box; other site 508767007587 G5 box; other site 508767007588 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 508767007589 Found in ATP-dependent protease La (LON); Region: LON; smart00464 508767007590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767007591 Walker A motif; other site 508767007592 ATP binding site [chemical binding]; other site 508767007593 Walker B motif; other site 508767007594 arginine finger; other site 508767007595 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 508767007596 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 508767007597 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 508767007598 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 508767007599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767007600 Walker A motif; other site 508767007601 ATP binding site [chemical binding]; other site 508767007602 Walker B motif; other site 508767007603 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 508767007604 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 508767007605 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 508767007606 oligomer interface [polypeptide binding]; other site 508767007607 active site residues [active] 508767007608 trigger factor; Provisional; Region: tig; PRK01490 508767007609 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 508767007610 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 508767007611 histidinol-phosphatase; Provisional; Region: PRK05588 508767007612 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 508767007613 active site 508767007614 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 508767007615 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 508767007616 metal binding site [ion binding]; metal-binding site 508767007617 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 508767007618 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 508767007619 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 508767007620 substrate binding site [chemical binding]; other site 508767007621 glutamase interaction surface [polypeptide binding]; other site 508767007622 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 508767007623 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 508767007624 catalytic residues [active] 508767007625 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 508767007626 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 508767007627 putative active site [active] 508767007628 oxyanion strand; other site 508767007629 catalytic triad [active] 508767007630 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 508767007631 putative active site pocket [active] 508767007632 4-fold oligomerization interface [polypeptide binding]; other site 508767007633 metal binding residues [ion binding]; metal-binding site 508767007634 3-fold/trimer interface [polypeptide binding]; other site 508767007635 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 508767007636 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508767007637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767007638 homodimer interface [polypeptide binding]; other site 508767007639 catalytic residue [active] 508767007640 histidinol dehydrogenase; Region: hisD; TIGR00069 508767007641 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 508767007642 NAD binding site [chemical binding]; other site 508767007643 dimerization interface [polypeptide binding]; other site 508767007644 product binding site; other site 508767007645 substrate binding site [chemical binding]; other site 508767007646 zinc binding site [ion binding]; other site 508767007647 catalytic residues [active] 508767007648 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 508767007649 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 508767007650 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 508767007651 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 508767007652 dimer interface [polypeptide binding]; other site 508767007653 motif 1; other site 508767007654 active site 508767007655 motif 2; other site 508767007656 motif 3; other site 508767007657 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508767007658 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508767007659 Coenzyme A binding pocket [chemical binding]; other site 508767007660 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 508767007661 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 508767007662 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 508767007663 Ligand Binding Site [chemical binding]; other site 508767007664 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 508767007665 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 508767007666 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508767007667 catalytic residue [active] 508767007668 EDD domain protein, DegV family; Region: DegV; TIGR00762 508767007669 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 508767007670 hypothetical protein; Provisional; Region: PRK04435 508767007671 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 508767007672 homoserine kinase; Provisional; Region: PRK01212 508767007673 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 508767007674 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 508767007675 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 508767007676 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 508767007677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767007678 catalytic residue [active] 508767007679 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 508767007680 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 508767007681 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 508767007682 Ion channel; Region: Ion_trans_2; pfam07885 508767007683 Protein of unknown function (DUF3867); Region: DUF3867; pfam12983 508767007684 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 508767007685 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 508767007686 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 508767007687 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 508767007688 active site 508767007689 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 508767007690 active site 508767007691 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 508767007692 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 508767007693 inhibitor-cofactor binding pocket; inhibition site 508767007694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767007695 catalytic residue [active] 508767007696 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 508767007697 dimer interface [polypeptide binding]; other site 508767007698 active site 508767007699 Schiff base residues; other site 508767007700 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 508767007701 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 508767007702 active site 508767007703 SAM binding site [chemical binding]; other site 508767007704 homodimer interface [polypeptide binding]; other site 508767007705 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 508767007706 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 508767007707 active site 508767007708 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 508767007709 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 508767007710 domain interfaces; other site 508767007711 active site 508767007712 precorrin-2 dehydrogenase; Provisional; Region: PRK05562 508767007713 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 508767007714 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 508767007715 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 508767007716 tRNA; other site 508767007717 putative tRNA binding site [nucleotide binding]; other site 508767007718 putative NADP binding site [chemical binding]; other site 508767007719 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 508767007720 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 508767007721 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 508767007722 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 508767007723 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 508767007724 catalytic residue [active] 508767007725 putative FPP diphosphate binding site; other site 508767007726 putative FPP binding hydrophobic cleft; other site 508767007727 dimer interface [polypeptide binding]; other site 508767007728 putative IPP diphosphate binding site; other site 508767007729 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 508767007730 Na2 binding site [ion binding]; other site 508767007731 putative substrate binding site 1 [chemical binding]; other site 508767007732 Na binding site 1 [ion binding]; other site 508767007733 putative substrate binding site 2 [chemical binding]; other site 508767007734 homoserine O-succinyltransferase; Provisional; Region: PRK05368 508767007735 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 508767007736 proposed active site lysine [active] 508767007737 conserved cys residue [active] 508767007738 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 508767007739 sugar phosphate phosphatase; Provisional; Region: PRK10513 508767007740 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767007741 active site 508767007742 motif I; other site 508767007743 motif II; other site 508767007744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767007745 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 508767007746 Domain of unknown function DUF; Region: DUF204; pfam02659 508767007747 cobyric acid synthase; Provisional; Region: PRK00784 508767007748 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 508767007749 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 508767007750 catalytic triad [active] 508767007751 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 508767007752 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 508767007753 Ligand Binding Site [chemical binding]; other site 508767007754 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 508767007755 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508767007756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767007757 homodimer interface [polypeptide binding]; other site 508767007758 catalytic residue [active] 508767007759 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 508767007760 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 508767007761 catalytic core [active] 508767007762 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 508767007763 cobalamin synthase; Reviewed; Region: cobS; PRK00235 508767007764 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 508767007765 ATP binding site [chemical binding]; other site 508767007766 Walker B motif; other site 508767007767 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 508767007768 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 508767007769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767007770 dimer interface [polypeptide binding]; other site 508767007771 conserved gate region; other site 508767007772 putative PBP binding loops; other site 508767007773 ABC-ATPase subunit interface; other site 508767007774 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 508767007775 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 508767007776 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 508767007777 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 508767007778 Walker A/P-loop; other site 508767007779 ATP binding site [chemical binding]; other site 508767007780 Q-loop/lid; other site 508767007781 ABC transporter signature motif; other site 508767007782 Walker B; other site 508767007783 D-loop; other site 508767007784 H-loop/switch region; other site 508767007785 FOG: CBS domain [General function prediction only]; Region: COG0517 508767007786 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 508767007787 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 508767007788 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508767007789 DNA-binding site [nucleotide binding]; DNA binding site 508767007790 TrkA-C domain; Region: TrkA_C; pfam02080 508767007791 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 508767007792 dimer interface [polypeptide binding]; other site 508767007793 catalytic triad [active] 508767007794 peroxidatic and resolving cysteines [active] 508767007795 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 508767007796 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 508767007797 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 508767007798 putative dimer interface [polypeptide binding]; other site 508767007799 active site pocket [active] 508767007800 putative cataytic base [active] 508767007801 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 508767007802 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 508767007803 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 508767007804 active site 508767007805 SAM binding site [chemical binding]; other site 508767007806 homodimer interface [polypeptide binding]; other site 508767007807 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 508767007808 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 508767007809 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 508767007810 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 508767007811 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 508767007812 active site 508767007813 SAM binding site [chemical binding]; other site 508767007814 homodimer interface [polypeptide binding]; other site 508767007815 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 508767007816 active site 508767007817 SAM binding site [chemical binding]; other site 508767007818 homodimer interface [polypeptide binding]; other site 508767007819 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 508767007820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 508767007821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767007822 S-adenosylmethionine binding site [chemical binding]; other site 508767007823 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 508767007824 active site 508767007825 putative homodimer interface [polypeptide binding]; other site 508767007826 SAM binding site [chemical binding]; other site 508767007827 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 508767007828 precorrin-8X methylmutase; Validated; Region: cbiC; PRK05575 508767007829 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 508767007830 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 508767007831 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 508767007832 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 508767007833 catalytic triad [active] 508767007834 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 508767007835 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 508767007836 active site 508767007837 C-terminal domain interface [polypeptide binding]; other site 508767007838 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 508767007839 active site 508767007840 N-terminal domain interface [polypeptide binding]; other site 508767007841 Uncharacterized conserved protein [Function unknown]; Region: COG2433 508767007842 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 508767007843 Na2 binding site [ion binding]; other site 508767007844 putative substrate binding site 1 [chemical binding]; other site 508767007845 Na binding site 1 [ion binding]; other site 508767007846 putative substrate binding site 2 [chemical binding]; other site 508767007847 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 508767007848 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 508767007849 putative substrate binding site [chemical binding]; other site 508767007850 putative ATP binding site [chemical binding]; other site 508767007851 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 508767007852 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 508767007853 active site 508767007854 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 508767007855 L-idonate 5-dehydrogenase; Region: PLN02702 508767007856 inhibitor binding site; inhibition site 508767007857 catalytic Zn binding site [ion binding]; other site 508767007858 structural Zn binding site [ion binding]; other site 508767007859 NADP binding site [chemical binding]; other site 508767007860 tetramer interface [polypeptide binding]; other site 508767007861 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 508767007862 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 508767007863 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508767007864 putative DNA binding site [nucleotide binding]; other site 508767007865 putative Zn2+ binding site [ion binding]; other site 508767007866 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 508767007867 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 508767007868 nucleotide binding site [chemical binding]; other site 508767007869 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 508767007870 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 508767007871 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 508767007872 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 508767007873 Response regulator receiver domain; Region: Response_reg; pfam00072 508767007874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767007875 active site 508767007876 phosphorylation site [posttranslational modification] 508767007877 intermolecular recognition site; other site 508767007878 dimerization interface [polypeptide binding]; other site 508767007879 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 508767007880 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 508767007881 PyrR binding site 508767007882 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767007883 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 508767007884 catalytic residue [active] 508767007885 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 508767007886 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 508767007887 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767007888 dimer interface [polypeptide binding]; other site 508767007889 putative CheW interface [polypeptide binding]; other site 508767007890 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 508767007891 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 508767007892 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 508767007893 Walker A/P-loop; other site 508767007894 ATP binding site [chemical binding]; other site 508767007895 Q-loop/lid; other site 508767007896 ABC transporter signature motif; other site 508767007897 Walker B; other site 508767007898 D-loop; other site 508767007899 H-loop/switch region; other site 508767007900 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 508767007901 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 508767007902 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767007903 Walker A/P-loop; other site 508767007904 ATP binding site [chemical binding]; other site 508767007905 Q-loop/lid; other site 508767007906 ABC transporter signature motif; other site 508767007907 Walker B; other site 508767007908 D-loop; other site 508767007909 H-loop/switch region; other site 508767007910 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508767007911 MarR family; Region: MarR_2; pfam12802 508767007912 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 508767007913 nucleotide binding site [chemical binding]; other site 508767007914 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 508767007915 active site 508767007916 metal binding site [ion binding]; metal-binding site 508767007917 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 508767007918 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 508767007919 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767007920 active site 508767007921 motif I; other site 508767007922 motif II; other site 508767007923 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 508767007924 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508767007925 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508767007926 DNA binding site [nucleotide binding] 508767007927 domain linker motif; other site 508767007928 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 508767007929 dimerization interface [polypeptide binding]; other site 508767007930 ligand binding site [chemical binding]; other site 508767007931 zinc transporter ZupT; Provisional; Region: PRK04201 508767007932 ZIP Zinc transporter; Region: Zip; pfam02535 508767007933 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 508767007934 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 508767007935 nucleotide binding site/active site [active] 508767007936 HIT family signature motif; other site 508767007937 catalytic residue [active] 508767007938 Predicted secreted protein [Function unknown]; Region: COG4086 508767007939 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 508767007940 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 508767007941 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 508767007942 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 508767007943 ArsC family; Region: ArsC; pfam03960 508767007944 putative ArsC-like catalytic residues; other site 508767007945 putative TRX-like catalytic residues [active] 508767007946 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 508767007947 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 508767007948 Domain of unknown function (DUF368); Region: DUF368; pfam04018 508767007949 EDD domain protein, DegV family; Region: DegV; TIGR00762 508767007950 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 508767007951 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 508767007952 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 508767007953 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 508767007954 active site 508767007955 catalytic motif [active] 508767007956 Zn binding site [ion binding]; other site 508767007957 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 508767007958 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 508767007959 TM-ABC transporter signature motif; other site 508767007960 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 508767007961 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 508767007962 TM-ABC transporter signature motif; other site 508767007963 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 508767007964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767007965 Walker A/P-loop; other site 508767007966 ATP binding site [chemical binding]; other site 508767007967 Q-loop/lid; other site 508767007968 ABC transporter signature motif; other site 508767007969 Walker B; other site 508767007970 D-loop; other site 508767007971 H-loop/switch region; other site 508767007972 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 508767007973 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 508767007974 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 508767007975 ligand binding site [chemical binding]; other site 508767007976 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508767007977 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508767007978 DNA binding site [nucleotide binding] 508767007979 domain linker motif; other site 508767007980 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 508767007981 dimerization interface [polypeptide binding]; other site 508767007982 ligand binding site [chemical binding]; other site 508767007983 hypothetical protein; Validated; Region: PRK07682 508767007984 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508767007985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767007986 homodimer interface [polypeptide binding]; other site 508767007987 catalytic residue [active] 508767007988 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 508767007989 AsnC family; Region: AsnC_trans_reg; pfam01037 508767007990 T-box leader 508767007991 pullulanase, type I; Region: pulA_typeI; TIGR02104 508767007992 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 508767007993 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 508767007994 Ca binding site [ion binding]; other site 508767007995 active site 508767007996 catalytic site [active] 508767007997 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 508767007998 Na2 binding site [ion binding]; other site 508767007999 putative substrate binding site 1 [chemical binding]; other site 508767008000 Na binding site 1 [ion binding]; other site 508767008001 putative substrate binding site 2 [chemical binding]; other site 508767008002 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 508767008003 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 508767008004 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508767008005 catalytic residue [active] 508767008006 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 508767008007 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 508767008008 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 508767008009 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 508767008010 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767008011 dimer interface [polypeptide binding]; other site 508767008012 putative CheW interface [polypeptide binding]; other site 508767008013 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 508767008014 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508767008015 FeS/SAM binding site; other site 508767008016 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 508767008017 Protein of unknown function (DUF4001); Region: DUF4001; cl14848 508767008018 heat shock protein 90; Provisional; Region: PRK05218 508767008019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767008020 ATP binding site [chemical binding]; other site 508767008021 Mg2+ binding site [ion binding]; other site 508767008022 G-X-G motif; other site 508767008023 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 508767008024 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 508767008025 AAA domain; Region: AAA_23; pfam13476 508767008026 Walker A/P-loop; other site 508767008027 ATP binding site [chemical binding]; other site 508767008028 Q-loop/lid; other site 508767008029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767008030 ABC transporter signature motif; other site 508767008031 Walker B; other site 508767008032 D-loop; other site 508767008033 H-loop/switch region; other site 508767008034 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 508767008035 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 508767008036 active site 508767008037 metal binding site [ion binding]; metal-binding site 508767008038 DNA binding site [nucleotide binding] 508767008039 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 508767008040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 508767008041 Uncharacterized conserved protein [Function unknown]; Region: COG1434 508767008042 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 508767008043 putative active site [active] 508767008044 stationary phase survival protein SurE; Provisional; Region: PRK13933 508767008045 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 508767008046 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 508767008047 active site 508767008048 metal binding site [ion binding]; metal-binding site 508767008049 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 508767008050 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 508767008051 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767008052 dimerization interface [polypeptide binding]; other site 508767008053 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767008054 dimer interface [polypeptide binding]; other site 508767008055 putative CheW interface [polypeptide binding]; other site 508767008056 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767008057 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508767008058 active site 508767008059 motif I; other site 508767008060 motif II; other site 508767008061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 508767008062 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 508767008063 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 508767008064 putative kinase; Provisional; Region: PRK09954 508767008065 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 508767008066 putative DNA binding site [nucleotide binding]; other site 508767008067 putative Zn2+ binding site [ion binding]; other site 508767008068 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 508767008069 substrate binding site [chemical binding]; other site 508767008070 ATP binding site [chemical binding]; other site 508767008071 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508767008072 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 508767008073 active site 508767008074 NAD binding site [chemical binding]; other site 508767008075 metal binding site [ion binding]; metal-binding site 508767008076 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 508767008077 active site 508767008078 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 508767008079 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 508767008080 substrate binding site [chemical binding]; other site 508767008081 ATP binding site [chemical binding]; other site 508767008082 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 508767008083 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508767008084 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508767008085 DNA binding residues [nucleotide binding] 508767008086 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 508767008087 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767008088 active site 508767008089 motif I; other site 508767008090 motif II; other site 508767008091 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 508767008092 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 508767008093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767008094 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767008095 dimerization interface [polypeptide binding]; other site 508767008096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767008097 dimer interface [polypeptide binding]; other site 508767008098 phosphorylation site [posttranslational modification] 508767008099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767008100 ATP binding site [chemical binding]; other site 508767008101 Mg2+ binding site [ion binding]; other site 508767008102 G-X-G motif; other site 508767008103 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767008104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767008105 active site 508767008106 phosphorylation site [posttranslational modification] 508767008107 intermolecular recognition site; other site 508767008108 dimerization interface [polypeptide binding]; other site 508767008109 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767008110 DNA binding site [nucleotide binding] 508767008111 Endonuclease I; Region: Endonuclease_1; pfam04231 508767008112 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 508767008113 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 508767008114 putative ligand binding site [chemical binding]; other site 508767008115 putative NAD binding site [chemical binding]; other site 508767008116 catalytic site [active] 508767008117 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 508767008118 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 508767008119 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 508767008120 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 508767008121 DNA binding residues [nucleotide binding] 508767008122 drug binding residues [chemical binding]; other site 508767008123 dimer interface [polypeptide binding]; other site 508767008124 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 508767008125 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 508767008126 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 508767008127 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 508767008128 active site 508767008129 EamA-like transporter family; Region: EamA; cl17759 508767008130 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 508767008131 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 508767008132 dimerization interface [polypeptide binding]; other site 508767008133 active site 508767008134 L-aspartate oxidase; Provisional; Region: PRK06175 508767008135 FAD binding domain; Region: FAD_binding_2; pfam00890 508767008136 Quinolinate synthetase A protein; Region: NadA; pfam02445 508767008137 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 508767008138 Rubredoxin; Region: Rubredoxin; pfam00301 508767008139 iron binding site [ion binding]; other site 508767008140 Rubrerythrin [Energy production and conversion]; Region: COG1592 508767008141 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 508767008142 diiron binding motif [ion binding]; other site 508767008143 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 508767008144 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 508767008145 HNH endonuclease; Region: HNH_3; pfam13392 508767008146 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 508767008147 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 508767008148 G1 box; other site 508767008149 GTP/Mg2+ binding site [chemical binding]; other site 508767008150 Switch I region; other site 508767008151 G2 box; other site 508767008152 G3 box; other site 508767008153 Switch II region; other site 508767008154 G4 box; other site 508767008155 G5 box; other site 508767008156 Nucleoside recognition; Region: Gate; pfam07670 508767008157 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 508767008158 Nucleoside recognition; Region: Gate; pfam07670 508767008159 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 508767008160 FeoA domain; Region: FeoA; pfam04023 508767008161 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 508767008162 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508767008163 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 508767008164 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 508767008165 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 508767008166 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 508767008167 FeS/SAM binding site; other site 508767008168 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 508767008169 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 508767008170 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 508767008171 active site 508767008172 Zn binding site [ion binding]; other site 508767008173 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 508767008174 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767008175 dimer interface [polypeptide binding]; other site 508767008176 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 508767008177 putative CheW interface [polypeptide binding]; other site 508767008178 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 508767008179 CotJB protein; Region: CotJB; pfam12652 508767008180 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 508767008181 dimanganese center [ion binding]; other site 508767008182 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 508767008183 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 508767008184 4Fe-4S binding domain; Region: Fer4; pfam00037 508767008185 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 508767008186 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 508767008187 FAD binding pocket [chemical binding]; other site 508767008188 FAD binding motif [chemical binding]; other site 508767008189 phosphate binding motif [ion binding]; other site 508767008190 beta-alpha-beta structure motif; other site 508767008191 NAD binding pocket [chemical binding]; other site 508767008192 Iron coordination center [ion binding]; other site 508767008193 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 508767008194 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 508767008195 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 508767008196 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 508767008197 putative switch regulator; other site 508767008198 non-specific DNA interactions [nucleotide binding]; other site 508767008199 DNA binding site [nucleotide binding] 508767008200 sequence specific DNA binding site [nucleotide binding]; other site 508767008201 putative cAMP binding site [chemical binding]; other site 508767008202 Helix-turn-helix domain; Region: HTH_17; pfam12728 508767008203 PBP superfamily domain; Region: PBP_like; pfam12727 508767008204 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 508767008205 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 508767008206 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 508767008207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767008208 dimer interface [polypeptide binding]; other site 508767008209 conserved gate region; other site 508767008210 putative PBP binding loops; other site 508767008211 ABC-ATPase subunit interface; other site 508767008212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767008213 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 508767008214 Walker A/P-loop; other site 508767008215 ATP binding site [chemical binding]; other site 508767008216 Q-loop/lid; other site 508767008217 ABC transporter signature motif; other site 508767008218 Walker B; other site 508767008219 D-loop; other site 508767008220 H-loop/switch region; other site 508767008221 putative oxidoreductase; Provisional; Region: PRK12831 508767008222 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 508767008223 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 508767008224 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 508767008225 FAD binding pocket [chemical binding]; other site 508767008226 FAD binding motif [chemical binding]; other site 508767008227 phosphate binding motif [ion binding]; other site 508767008228 beta-alpha-beta structure motif; other site 508767008229 NAD binding pocket [chemical binding]; other site 508767008230 Iron coordination center [ion binding]; other site 508767008231 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 508767008232 SmpB-tmRNA interface; other site 508767008233 ribonuclease R; Region: RNase_R; TIGR02063 508767008234 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 508767008235 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 508767008236 RNB domain; Region: RNB; pfam00773 508767008237 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 508767008238 RNA binding site [nucleotide binding]; other site 508767008239 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 508767008240 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 508767008241 Preprotein translocase SecG subunit; Region: SecG; pfam03840 508767008242 enolase; Provisional; Region: eno; PRK00077 508767008243 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 508767008244 dimer interface [polypeptide binding]; other site 508767008245 metal binding site [ion binding]; metal-binding site 508767008246 substrate binding pocket [chemical binding]; other site 508767008247 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 508767008248 active site 508767008249 ATP binding site [chemical binding]; other site 508767008250 substrate binding site [chemical binding]; other site 508767008251 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 508767008252 phosphoglyceromutase; Provisional; Region: PRK05434 508767008253 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508767008254 Zn2+ binding site [ion binding]; other site 508767008255 Mg2+ binding site [ion binding]; other site 508767008256 Sensory domain found in PocR; Region: PocR; pfam10114 508767008257 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 508767008258 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 508767008259 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767008260 dimer interface [polypeptide binding]; other site 508767008261 putative CheW interface [polypeptide binding]; other site 508767008262 triosephosphate isomerase; Provisional; Region: PRK14567 508767008263 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 508767008264 substrate binding site [chemical binding]; other site 508767008265 dimer interface [polypeptide binding]; other site 508767008266 catalytic triad [active] 508767008267 Phosphoglycerate kinase; Region: PGK; pfam00162 508767008268 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 508767008269 substrate binding site [chemical binding]; other site 508767008270 hinge regions; other site 508767008271 ADP binding site [chemical binding]; other site 508767008272 catalytic site [active] 508767008273 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 508767008274 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 508767008275 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 508767008276 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 508767008277 Predicted transcriptional regulator [Transcription]; Region: COG3388 508767008278 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 508767008279 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 508767008280 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 508767008281 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 508767008282 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 508767008283 EDD domain protein, DegV family; Region: DegV; TIGR00762 508767008284 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 508767008285 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 508767008286 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508767008287 VanW like protein; Region: VanW; pfam04294 508767008288 G5 domain; Region: G5; pfam07501 508767008289 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 508767008290 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 508767008291 active site 508767008292 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767008293 dimerization interface [polypeptide binding]; other site 508767008294 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767008295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508767008296 dimer interface [polypeptide binding]; other site 508767008297 phosphorylation site [posttranslational modification] 508767008298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767008299 ATP binding site [chemical binding]; other site 508767008300 Mg2+ binding site [ion binding]; other site 508767008301 G-X-G motif; other site 508767008302 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767008303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767008304 active site 508767008305 phosphorylation site [posttranslational modification] 508767008306 intermolecular recognition site; other site 508767008307 dimerization interface [polypeptide binding]; other site 508767008308 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767008309 DNA binding site [nucleotide binding] 508767008310 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 508767008311 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 508767008312 ATP-grasp domain; Region: ATP-grasp_4; cl17255 508767008313 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 508767008314 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 508767008315 minor groove reading motif; other site 508767008316 helix-hairpin-helix signature motif; other site 508767008317 substrate binding pocket [chemical binding]; other site 508767008318 active site 508767008319 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 508767008320 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 508767008321 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 508767008322 putative acyl-acceptor binding pocket; other site 508767008323 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 508767008324 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 508767008325 serine O-acetyltransferase; Region: cysE; TIGR01172 508767008326 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 508767008327 trimer interface [polypeptide binding]; other site 508767008328 active site 508767008329 substrate binding site [chemical binding]; other site 508767008330 CoA binding site [chemical binding]; other site 508767008331 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 508767008332 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 508767008333 dimer interface [polypeptide binding]; other site 508767008334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767008335 catalytic residue [active] 508767008336 T-box leader 508767008337 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 508767008338 MgtE intracellular N domain; Region: MgtE_N; smart00924 508767008339 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 508767008340 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 508767008341 hypothetical protein; Provisional; Region: PRK00955 508767008342 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 508767008343 putative lipid kinase; Reviewed; Region: PRK13059 508767008344 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 508767008345 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 508767008346 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 508767008347 Rubrerythrin [Energy production and conversion]; Region: COG1592 508767008348 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 508767008349 binuclear metal center [ion binding]; other site 508767008350 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 508767008351 iron binding site [ion binding]; other site 508767008352 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 508767008353 SpoVR like protein; Region: SpoVR; pfam04293 508767008354 hypothetical protein; Provisional; Region: PRK05325 508767008355 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 508767008356 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 508767008357 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 508767008358 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508767008359 ATP binding site [chemical binding]; other site 508767008360 putative Mg++ binding site [ion binding]; other site 508767008361 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508767008362 nucleotide binding region [chemical binding]; other site 508767008363 ATP-binding site [chemical binding]; other site 508767008364 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 508767008365 HRDC domain; Region: HRDC; pfam00570 508767008366 NVEALA protein; Region: NVEALA; pfam14055 508767008367 FtsX-like permease family; Region: FtsX; pfam02687 508767008368 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508767008369 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 508767008370 Walker A/P-loop; other site 508767008371 ATP binding site [chemical binding]; other site 508767008372 Q-loop/lid; other site 508767008373 ABC transporter signature motif; other site 508767008374 Walker B; other site 508767008375 D-loop; other site 508767008376 H-loop/switch region; other site 508767008377 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767008378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767008379 ATP binding site [chemical binding]; other site 508767008380 Mg2+ binding site [ion binding]; other site 508767008381 G-X-G motif; other site 508767008382 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767008383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767008384 active site 508767008385 phosphorylation site [posttranslational modification] 508767008386 intermolecular recognition site; other site 508767008387 dimerization interface [polypeptide binding]; other site 508767008388 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767008389 DNA binding site [nucleotide binding] 508767008390 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508767008391 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 508767008392 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 508767008393 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 508767008394 Rubrerythrin [Energy production and conversion]; Region: COG1592 508767008395 binuclear metal center [ion binding]; other site 508767008396 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 508767008397 iron binding site [ion binding]; other site 508767008398 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 508767008399 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 508767008400 nucleophile elbow; other site 508767008401 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 508767008402 thiamine phosphate binding site [chemical binding]; other site 508767008403 active site 508767008404 pyrophosphate binding site [ion binding]; other site 508767008405 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 508767008406 substrate binding site [chemical binding]; other site 508767008407 multimerization interface [polypeptide binding]; other site 508767008408 ATP binding site [chemical binding]; other site 508767008409 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 508767008410 dimer interface [polypeptide binding]; other site 508767008411 substrate binding site [chemical binding]; other site 508767008412 ATP binding site [chemical binding]; other site 508767008413 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 508767008414 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 508767008415 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 508767008416 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 508767008417 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 508767008418 putative L-serine binding site [chemical binding]; other site 508767008419 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 508767008420 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 508767008421 active site 508767008422 Predicted membrane protein [Function unknown]; Region: COG2323 508767008423 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 508767008424 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 508767008425 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 508767008426 intersubunit interface [polypeptide binding]; other site 508767008427 active site 508767008428 zinc binding site [ion binding]; other site 508767008429 Na+ binding site [ion binding]; other site 508767008430 argininosuccinate synthase; Provisional; Region: PRK13820 508767008431 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 508767008432 ANP binding site [chemical binding]; other site 508767008433 Substrate Binding Site II [chemical binding]; other site 508767008434 Substrate Binding Site I [chemical binding]; other site 508767008435 argininosuccinate lyase; Provisional; Region: PRK00855 508767008436 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 508767008437 active sites [active] 508767008438 tetramer interface [polypeptide binding]; other site 508767008439 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 508767008440 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 508767008441 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 508767008442 heterotetramer interface [polypeptide binding]; other site 508767008443 active site pocket [active] 508767008444 cleavage site 508767008445 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 508767008446 feedback inhibition sensing region; other site 508767008447 homohexameric interface [polypeptide binding]; other site 508767008448 nucleotide binding site [chemical binding]; other site 508767008449 N-acetyl-L-glutamate binding site [chemical binding]; other site 508767008450 acetylornithine aminotransferase; Provisional; Region: PRK02627 508767008451 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 508767008452 inhibitor-cofactor binding pocket; inhibition site 508767008453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767008454 catalytic residue [active] 508767008455 ornithine carbamoyltransferase; Provisional; Region: PRK00779 508767008456 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 508767008457 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 508767008458 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 508767008459 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508767008460 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508767008461 metal binding site [ion binding]; metal-binding site 508767008462 active site 508767008463 I-site; other site 508767008464 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 508767008465 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 508767008466 putative active site [active] 508767008467 putative metal binding residues [ion binding]; other site 508767008468 signature motif; other site 508767008469 putative triphosphate binding site [ion binding]; other site 508767008470 dimer interface [polypeptide binding]; other site 508767008471 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 508767008472 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 508767008473 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 508767008474 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 508767008475 putative substrate binding site [chemical binding]; other site 508767008476 putative ATP binding site [chemical binding]; other site 508767008477 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 508767008478 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 508767008479 intersubunit interface [polypeptide binding]; other site 508767008480 active site 508767008481 zinc binding site [ion binding]; other site 508767008482 Na+ binding site [ion binding]; other site 508767008483 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 508767008484 active pocket/dimerization site; other site 508767008485 active site 508767008486 phosphorylation site [posttranslational modification] 508767008487 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 508767008488 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 508767008489 dimer interface [polypeptide binding]; other site 508767008490 active site 508767008491 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 508767008492 putative active site [active] 508767008493 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 508767008494 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508767008495 DNA-binding site [nucleotide binding]; DNA binding site 508767008496 UTRA domain; Region: UTRA; pfam07702 508767008497 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 508767008498 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 508767008499 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 508767008500 active site 508767008501 phosphorylation site [posttranslational modification] 508767008502 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 508767008503 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 508767008504 active site 508767008505 dimer interface [polypeptide binding]; other site 508767008506 prephenate dehydrogenase; Validated; Region: PRK08507 508767008507 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 508767008508 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 508767008509 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 508767008510 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 508767008511 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 508767008512 ADP binding site [chemical binding]; other site 508767008513 magnesium binding site [ion binding]; other site 508767008514 putative shikimate binding site; other site 508767008515 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 508767008516 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 508767008517 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 508767008518 shikimate binding site; other site 508767008519 NAD(P) binding site [chemical binding]; other site 508767008520 monofunctional chorismate mutase, gram positive-type, clade 2; Region: CM_mono_grmpos; TIGR01805 508767008521 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 508767008522 Prephenate dehydratase; Region: PDT; pfam00800 508767008523 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 508767008524 putative L-Phe binding site [chemical binding]; other site 508767008525 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 508767008526 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 508767008527 Tetramer interface [polypeptide binding]; other site 508767008528 active site 508767008529 FMN-binding site [chemical binding]; other site 508767008530 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 508767008531 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 508767008532 hinge; other site 508767008533 active site 508767008534 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 508767008535 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 508767008536 active site 508767008537 dimer interface [polypeptide binding]; other site 508767008538 metal binding site [ion binding]; metal-binding site 508767008539 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 508767008540 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 508767008541 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 508767008542 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 508767008543 putative active site [active] 508767008544 catalytic site [active] 508767008545 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 508767008546 putative active site [active] 508767008547 catalytic site [active] 508767008548 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 508767008549 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 508767008550 Na binding site [ion binding]; other site 508767008551 T-box leader 508767008552 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 508767008553 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 508767008554 HIGH motif; other site 508767008555 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 508767008556 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 508767008557 active site 508767008558 KMSKS motif; other site 508767008559 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 508767008560 tRNA binding surface [nucleotide binding]; other site 508767008561 Cache domain; Region: Cache_1; pfam02743 508767008562 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767008563 dimerization interface [polypeptide binding]; other site 508767008564 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767008565 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767008566 dimer interface [polypeptide binding]; other site 508767008567 putative CheW interface [polypeptide binding]; other site 508767008568 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 508767008569 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 508767008570 trimer interface [polypeptide binding]; other site 508767008571 active site 508767008572 substrate binding site [chemical binding]; other site 508767008573 CoA binding site [chemical binding]; other site 508767008574 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 508767008575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 508767008576 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 508767008577 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 508767008578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767008579 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 508767008580 Walker A motif; other site 508767008581 ATP binding site [chemical binding]; other site 508767008582 Walker B motif; other site 508767008583 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 508767008584 synthetase active site [active] 508767008585 NTP binding site [chemical binding]; other site 508767008586 metal binding site [ion binding]; metal-binding site 508767008587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 508767008588 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 508767008589 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767008590 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767008591 dimer interface [polypeptide binding]; other site 508767008592 putative CheW interface [polypeptide binding]; other site 508767008593 Stage II sporulation protein; Region: SpoIID; pfam08486 508767008594 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 508767008595 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 508767008596 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 508767008597 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 508767008598 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 508767008599 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 508767008600 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 508767008601 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 508767008602 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 508767008603 putative active site [active] 508767008604 putative metal binding site [ion binding]; other site 508767008605 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 508767008606 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 508767008607 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 508767008608 active site 508767008609 HIGH motif; other site 508767008610 dimer interface [polypeptide binding]; other site 508767008611 KMSKS motif; other site 508767008612 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508767008613 RNA binding surface [nucleotide binding]; other site 508767008614 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 508767008615 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 508767008616 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 508767008617 Spore germination protein; Region: Spore_permease; cl17796 508767008618 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 508767008619 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 508767008620 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 508767008621 active site 508767008622 HIGH motif; other site 508767008623 dimer interface [polypeptide binding]; other site 508767008624 KMSKS motif; other site 508767008625 Cache domain; Region: Cache_1; pfam02743 508767008626 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767008627 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767008628 dimer interface [polypeptide binding]; other site 508767008629 putative CheW interface [polypeptide binding]; other site 508767008630 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 508767008631 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 508767008632 active site 508767008633 tetramer interface; other site 508767008634 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 508767008635 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 508767008636 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 508767008637 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 508767008638 Bacterial sugar transferase; Region: Bac_transf; pfam02397 508767008639 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 508767008640 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 508767008641 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 508767008642 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 508767008643 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 508767008644 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 508767008645 active site 508767008646 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 508767008647 homodimer interface [polypeptide binding]; other site 508767008648 O-Antigen ligase; Region: Wzy_C; pfam04932 508767008649 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 508767008650 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 508767008651 NAD(P) binding site [chemical binding]; other site 508767008652 homodimer interface [polypeptide binding]; other site 508767008653 substrate binding site [chemical binding]; other site 508767008654 active site 508767008655 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 508767008656 active site 508767008657 LicD family; Region: LicD; pfam04991 508767008658 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 508767008659 active site 508767008660 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 508767008661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767008662 dimer interface [polypeptide binding]; other site 508767008663 conserved gate region; other site 508767008664 putative PBP binding loops; other site 508767008665 ABC-ATPase subunit interface; other site 508767008666 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 508767008667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767008668 dimer interface [polypeptide binding]; other site 508767008669 conserved gate region; other site 508767008670 putative PBP binding loops; other site 508767008671 ABC-ATPase subunit interface; other site 508767008672 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 508767008673 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 508767008674 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 508767008675 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 508767008676 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767008677 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508767008678 active site 508767008679 motif I; other site 508767008680 motif II; other site 508767008681 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 508767008682 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767008683 dimerization interface [polypeptide binding]; other site 508767008684 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 508767008685 PAS fold; Region: PAS_3; pfam08447 508767008686 putative active site [active] 508767008687 heme pocket [chemical binding]; other site 508767008688 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508767008689 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508767008690 metal binding site [ion binding]; metal-binding site 508767008691 active site 508767008692 I-site; other site 508767008693 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 508767008694 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 508767008695 EamA-like transporter family; Region: EamA; cl17759 508767008696 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767008697 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 508767008698 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 508767008699 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 508767008700 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 508767008701 active site 508767008702 metal-binding site 508767008703 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 508767008704 active site 508767008705 metal-binding site 508767008706 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 508767008707 Phosphotransferase enzyme family; Region: APH; pfam01636 508767008708 active site 508767008709 ATP binding site [chemical binding]; other site 508767008710 substrate binding site [chemical binding]; other site 508767008711 dimer interface [polypeptide binding]; other site 508767008712 YcxB-like protein; Region: YcxB; pfam14317 508767008713 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508767008714 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508767008715 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767008716 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 508767008717 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767008718 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767008719 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767008720 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767008721 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 508767008722 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 508767008723 active site 508767008724 metal binding site [ion binding]; metal-binding site 508767008725 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 508767008726 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767008727 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767008728 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767008729 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767008730 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 508767008731 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 508767008732 active site 508767008733 metal binding site [ion binding]; metal-binding site 508767008734 ATP cone domain; Region: ATP-cone; pfam03477 508767008735 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767008736 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508767008737 active site 508767008738 motif I; other site 508767008739 motif II; other site 508767008740 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767008741 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 508767008742 dimer interface [polypeptide binding]; other site 508767008743 pyridoxal binding site [chemical binding]; other site 508767008744 ATP binding site [chemical binding]; other site 508767008745 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 508767008746 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 508767008747 catalytic residues [active] 508767008748 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 508767008749 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 508767008750 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 508767008751 active site 508767008752 Cache domain; Region: Cache_1; pfam02743 508767008753 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767008754 dimerization interface [polypeptide binding]; other site 508767008755 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767008756 dimer interface [polypeptide binding]; other site 508767008757 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 508767008758 putative CheW interface [polypeptide binding]; other site 508767008759 Cache domain; Region: Cache_1; pfam02743 508767008760 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767008761 dimerization interface [polypeptide binding]; other site 508767008762 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767008763 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767008764 dimer interface [polypeptide binding]; other site 508767008765 putative CheW interface [polypeptide binding]; other site 508767008766 putative oxidoreductase; Provisional; Region: PRK12831 508767008767 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508767008768 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508767008769 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508767008770 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 508767008771 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 508767008772 FAD binding pocket [chemical binding]; other site 508767008773 FAD binding motif [chemical binding]; other site 508767008774 phosphate binding motif [ion binding]; other site 508767008775 beta-alpha-beta structure motif; other site 508767008776 NAD binding pocket [chemical binding]; other site 508767008777 Iron coordination center [ion binding]; other site 508767008778 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508767008779 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 508767008780 putative active site [active] 508767008781 metal binding site [ion binding]; metal-binding site 508767008782 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 508767008783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767008784 Walker A motif; other site 508767008785 ATP binding site [chemical binding]; other site 508767008786 Walker B motif; other site 508767008787 arginine finger; other site 508767008788 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 508767008789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 508767008790 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 508767008791 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 508767008792 G1 box; other site 508767008793 putative GEF interaction site [polypeptide binding]; other site 508767008794 GTP/Mg2+ binding site [chemical binding]; other site 508767008795 Switch I region; other site 508767008796 G2 box; other site 508767008797 G3 box; other site 508767008798 Switch II region; other site 508767008799 G4 box; other site 508767008800 G5 box; other site 508767008801 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 508767008802 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767008803 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767008804 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 508767008805 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508767008806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 508767008807 binding surface 508767008808 TPR motif; other site 508767008809 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508767008810 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 508767008811 GAF domain; Region: GAF_3; pfam13492 508767008812 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508767008813 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508767008814 metal binding site [ion binding]; metal-binding site 508767008815 active site 508767008816 I-site; other site 508767008817 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508767008818 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508767008819 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767008820 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508767008821 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508767008822 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767008823 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508767008824 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767008825 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767008826 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767008827 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767008828 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767008829 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 508767008830 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 508767008831 HAMP domain; Region: HAMP; pfam00672 508767008832 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767008833 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767008834 dimer interface [polypeptide binding]; other site 508767008835 putative CheW interface [polypeptide binding]; other site 508767008836 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767008837 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 508767008838 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 508767008839 DNA binding residues [nucleotide binding] 508767008840 dimerization interface [polypeptide binding]; other site 508767008841 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767008842 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767008843 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508767008844 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508767008845 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508767008846 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767008847 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767008848 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508767008849 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508767008850 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767008851 middle domain of the stomatal closure-related actin binding protein1; Region: SCAB1_middle; cd11675 508767008852 PH domain interface [polypeptide binding]; other site 508767008853 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767008854 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767008855 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767008856 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767008857 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767008858 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 508767008859 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 508767008860 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 508767008861 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 508767008862 active site 508767008863 Zn binding site [ion binding]; other site 508767008864 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 508767008865 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 508767008866 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 508767008867 active site 508767008868 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 508767008869 acyl carrier protein; Provisional; Region: PRK07081 508767008870 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 508767008871 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 508767008872 acyl-activating enzyme (AAE) consensus motif; other site 508767008873 AMP binding site [chemical binding]; other site 508767008874 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 508767008875 catalytic triad [active] 508767008876 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 508767008877 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 508767008878 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 508767008879 active site 508767008880 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 508767008881 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 508767008882 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 508767008883 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 508767008884 putative NAD(P) binding site [chemical binding]; other site 508767008885 putative catalytic Zn binding site [ion binding]; other site 508767008886 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 508767008887 substrate binding site; other site 508767008888 dimer interface; other site 508767008889 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 508767008890 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 508767008891 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 508767008892 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 508767008893 Walker A/P-loop; other site 508767008894 ATP binding site [chemical binding]; other site 508767008895 Q-loop/lid; other site 508767008896 ABC transporter signature motif; other site 508767008897 Walker B; other site 508767008898 D-loop; other site 508767008899 H-loop/switch region; other site 508767008900 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 508767008901 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 508767008902 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 508767008903 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 508767008904 NADP binding site [chemical binding]; other site 508767008905 active site 508767008906 putative substrate binding site [chemical binding]; other site 508767008907 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 508767008908 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 508767008909 active site 508767008910 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 508767008911 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 508767008912 NAD binding site [chemical binding]; other site 508767008913 substrate binding site [chemical binding]; other site 508767008914 homodimer interface [polypeptide binding]; other site 508767008915 active site 508767008916 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 508767008917 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 508767008918 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 508767008919 substrate binding site; other site 508767008920 tetramer interface; other site 508767008921 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 508767008922 Bacterial sugar transferase; Region: Bac_transf; pfam02397 508767008923 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 508767008924 O-Antigen ligase; Region: Wzy_C; pfam04932 508767008925 Protein of unknown function DUF86; Region: DUF86; pfam01934 508767008926 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 508767008927 active site 508767008928 NTP binding site [chemical binding]; other site 508767008929 metal binding triad [ion binding]; metal-binding site 508767008930 antibiotic binding site [chemical binding]; other site 508767008931 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767008932 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767008933 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767008934 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767008935 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767008936 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767008937 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508767008938 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 508767008939 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 508767008940 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 508767008941 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 508767008942 AP (apurinic/apyrimidinic) site pocket; other site 508767008943 DNA interaction; other site 508767008944 Metal-binding active site; metal-binding site 508767008945 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 508767008946 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 508767008947 intersubunit interface [polypeptide binding]; other site 508767008948 active site 508767008949 Zn2+ binding site [ion binding]; other site 508767008950 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 508767008951 active site 508767008952 P-loop; other site 508767008953 phosphorylation site [posttranslational modification] 508767008954 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 508767008955 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 508767008956 active site 508767008957 phosphorylation site [posttranslational modification] 508767008958 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 508767008959 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 508767008960 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 508767008961 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508767008962 putative DNA binding site [nucleotide binding]; other site 508767008963 putative Zn2+ binding site [ion binding]; other site 508767008964 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 508767008965 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 508767008966 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 508767008967 active site 508767008968 metal binding site [ion binding]; metal-binding site 508767008969 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 508767008970 Cation efflux family; Region: Cation_efflux; pfam01545 508767008971 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 508767008972 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 508767008973 PYR/PP interface [polypeptide binding]; other site 508767008974 dimer interface [polypeptide binding]; other site 508767008975 TPP binding site [chemical binding]; other site 508767008976 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 508767008977 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 508767008978 TPP-binding site [chemical binding]; other site 508767008979 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 508767008980 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767008981 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767008982 dimer interface [polypeptide binding]; other site 508767008983 putative CheW interface [polypeptide binding]; other site 508767008984 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 508767008985 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 508767008986 Walker A/P-loop; other site 508767008987 ATP binding site [chemical binding]; other site 508767008988 Q-loop/lid; other site 508767008989 ABC transporter signature motif; other site 508767008990 Walker B; other site 508767008991 D-loop; other site 508767008992 H-loop/switch region; other site 508767008993 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 508767008994 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 508767008995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508767008996 dimer interface [polypeptide binding]; other site 508767008997 conserved gate region; other site 508767008998 putative PBP binding loops; other site 508767008999 ABC-ATPase subunit interface; other site 508767009000 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 508767009001 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 508767009002 substrate binding pocket [chemical binding]; other site 508767009003 membrane-bound complex binding site; other site 508767009004 hinge residues; other site 508767009005 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 508767009006 Part of AAA domain; Region: AAA_19; pfam13245 508767009007 Family description; Region: UvrD_C_2; pfam13538 508767009008 FtsH Extracellular; Region: FtsH_ext; pfam06480 508767009009 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 508767009010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767009011 Walker A motif; other site 508767009012 ATP binding site [chemical binding]; other site 508767009013 Walker B motif; other site 508767009014 arginine finger; other site 508767009015 Peptidase family M41; Region: Peptidase_M41; pfam01434 508767009016 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 508767009017 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 508767009018 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 508767009019 Catalytic site [active] 508767009020 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 508767009021 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 508767009022 Catalytic site [active] 508767009023 diaminopimelate decarboxylase; Region: lysA; TIGR01048 508767009024 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 508767009025 active site 508767009026 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 508767009027 substrate binding site [chemical binding]; other site 508767009028 catalytic residues [active] 508767009029 dimer interface [polypeptide binding]; other site 508767009030 Lysine riboswitch 508767009031 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 508767009032 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 508767009033 amidase catalytic site [active] 508767009034 Zn binding residues [ion binding]; other site 508767009035 substrate binding site [chemical binding]; other site 508767009036 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767009037 dimerization interface [polypeptide binding]; other site 508767009038 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767009039 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767009040 dimer interface [polypeptide binding]; other site 508767009041 putative CheW interface [polypeptide binding]; other site 508767009042 aspartate aminotransferase; Provisional; Region: PRK06836 508767009043 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508767009044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767009045 homodimer interface [polypeptide binding]; other site 508767009046 catalytic residue [active] 508767009047 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 508767009048 metal ion-dependent adhesion site (MIDAS); other site 508767009049 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 508767009050 Protein of unknown function (DUF2572); Region: DUF2572; pfam10833 508767009051 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 508767009052 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 508767009053 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 508767009054 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 508767009055 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 508767009056 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 508767009057 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 508767009058 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 508767009059 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 508767009060 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 508767009061 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 508767009062 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 508767009063 Walker A motif; other site 508767009064 ATP binding site [chemical binding]; other site 508767009065 Walker B motif; other site 508767009066 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 508767009067 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 508767009068 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767009069 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767009070 dimer interface [polypeptide binding]; other site 508767009071 putative CheW interface [polypeptide binding]; other site 508767009072 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 508767009073 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 508767009074 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 508767009075 metal-binding site [ion binding] 508767009076 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 508767009077 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 508767009078 metal-binding site [ion binding] 508767009079 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 508767009080 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 508767009081 metal-binding site [ion binding] 508767009082 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508767009083 Soluble P-type ATPase [General function prediction only]; Region: COG4087 508767009084 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 508767009085 putative homodimer interface [polypeptide binding]; other site 508767009086 putative homotetramer interface [polypeptide binding]; other site 508767009087 putative allosteric switch controlling residues; other site 508767009088 putative metal binding site [ion binding]; other site 508767009089 putative homodimer-homodimer interface [polypeptide binding]; other site 508767009090 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 508767009091 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 508767009092 metal binding site [ion binding]; metal-binding site 508767009093 dimer interface [polypeptide binding]; other site 508767009094 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 508767009095 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 508767009096 catalytic triad [active] 508767009097 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 508767009098 Predicted amidohydrolase [General function prediction only]; Region: COG0388 508767009099 active site 508767009100 catalytic triad [active] 508767009101 dimer interface [polypeptide binding]; other site 508767009102 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 508767009103 heme-binding site [chemical binding]; other site 508767009104 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 508767009105 heme-binding site [chemical binding]; other site 508767009106 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 508767009107 heme-binding site [chemical binding]; other site 508767009108 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 508767009109 heme-binding site [chemical binding]; other site 508767009110 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 508767009111 heme-binding site [chemical binding]; other site 508767009112 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 508767009113 heme-binding site [chemical binding]; other site 508767009114 Protein of unknown function (DUF454); Region: DUF454; cl01063 508767009115 hypothetical protein; Provisional; Region: PRK10410 508767009116 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 508767009117 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 508767009118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767009119 Walker A/P-loop; other site 508767009120 ATP binding site [chemical binding]; other site 508767009121 Q-loop/lid; other site 508767009122 ABC transporter signature motif; other site 508767009123 Walker B; other site 508767009124 D-loop; other site 508767009125 H-loop/switch region; other site 508767009126 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 508767009127 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 508767009128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767009129 Walker A/P-loop; other site 508767009130 ATP binding site [chemical binding]; other site 508767009131 Q-loop/lid; other site 508767009132 ABC transporter signature motif; other site 508767009133 Walker B; other site 508767009134 D-loop; other site 508767009135 H-loop/switch region; other site 508767009136 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 508767009137 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 508767009138 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 508767009139 TraX protein; Region: TraX; cl05434 508767009140 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 508767009141 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508767009142 RNA binding surface [nucleotide binding]; other site 508767009143 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 508767009144 active site 508767009145 uracil binding [chemical binding]; other site 508767009146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508767009147 salt bridge; other site 508767009148 non-specific DNA binding site [nucleotide binding]; other site 508767009149 sequence-specific DNA binding site [nucleotide binding]; other site 508767009150 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 508767009151 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 508767009152 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 508767009153 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 508767009154 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 508767009155 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 508767009156 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 508767009157 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 508767009158 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 508767009159 Ligand binding site; other site 508767009160 metal-binding site 508767009161 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 508767009162 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 508767009163 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 508767009164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767009165 S-adenosylmethionine binding site [chemical binding]; other site 508767009166 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 508767009167 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 508767009168 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 508767009169 domain interfaces; other site 508767009170 active site 508767009171 6-phosphofructokinase; Provisional; Region: PRK03202 508767009172 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 508767009173 active site 508767009174 ADP/pyrophosphate binding site [chemical binding]; other site 508767009175 dimerization interface [polypeptide binding]; other site 508767009176 allosteric effector site; other site 508767009177 fructose-1,6-bisphosphate binding site; other site 508767009178 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 508767009179 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 508767009180 active site 508767009181 PHP Thumb interface [polypeptide binding]; other site 508767009182 metal binding site [ion binding]; metal-binding site 508767009183 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 508767009184 generic binding surface II; other site 508767009185 generic binding surface I; other site 508767009186 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 508767009187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 508767009188 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 508767009189 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 508767009190 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 508767009191 putative substrate binding pocket [chemical binding]; other site 508767009192 dimer interface [polypeptide binding]; other site 508767009193 phosphate binding site [ion binding]; other site 508767009194 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 508767009195 shikimate kinase; Provisional; Region: PRK13947 508767009196 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 508767009197 FAD binding domain; Region: FAD_binding_4; pfam01565 508767009198 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 508767009199 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 508767009200 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 508767009201 GIY-YIG motif/motif A; other site 508767009202 active site 508767009203 catalytic site [active] 508767009204 putative DNA binding site [nucleotide binding]; other site 508767009205 metal binding site [ion binding]; metal-binding site 508767009206 UvrB/uvrC motif; Region: UVR; pfam02151 508767009207 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 508767009208 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 508767009209 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 508767009210 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 508767009211 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 508767009212 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 508767009213 phosphopeptide binding site; other site 508767009214 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 508767009215 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 508767009216 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 508767009217 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 508767009218 excinuclease ABC subunit B; Provisional; Region: PRK05298 508767009219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767009220 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508767009221 Walker A/P-loop; other site 508767009222 ATP binding site [chemical binding]; other site 508767009223 ATP binding site [chemical binding]; other site 508767009224 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508767009225 nucleotide binding region [chemical binding]; other site 508767009226 ATP-binding site [chemical binding]; other site 508767009227 Ultra-violet resistance protein B; Region: UvrB; pfam12344 508767009228 UvrB/uvrC motif; Region: UVR; pfam02151 508767009229 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 508767009230 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 508767009231 protein binding site [polypeptide binding]; other site 508767009232 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 508767009233 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 508767009234 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 508767009235 protein binding site [polypeptide binding]; other site 508767009236 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 508767009237 Catalytic dyad [active] 508767009238 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 508767009239 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 508767009240 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 508767009241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508767009242 Walker A/P-loop; other site 508767009243 ATP binding site [chemical binding]; other site 508767009244 Q-loop/lid; other site 508767009245 ABC transporter signature motif; other site 508767009246 Walker B; other site 508767009247 D-loop; other site 508767009248 H-loop/switch region; other site 508767009249 Uncharacterized conserved protein [Function unknown]; Region: COG1284 508767009250 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508767009251 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 508767009252 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 508767009253 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 508767009254 PYR/PP interface [polypeptide binding]; other site 508767009255 dimer interface [polypeptide binding]; other site 508767009256 TPP binding site [chemical binding]; other site 508767009257 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 508767009258 transketolase; Reviewed; Region: PRK05899 508767009259 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 508767009260 TPP-binding site [chemical binding]; other site 508767009261 dimer interface [polypeptide binding]; other site 508767009262 PemK-like protein; Region: PemK; pfam02452 508767009263 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 508767009264 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 508767009265 putative substrate binding site [chemical binding]; other site 508767009266 putative ATP binding site [chemical binding]; other site 508767009267 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 508767009268 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 508767009269 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 508767009270 dimer interface [polypeptide binding]; other site 508767009271 ssDNA binding site [nucleotide binding]; other site 508767009272 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508767009273 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 508767009274 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 508767009275 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 508767009276 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 508767009277 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 508767009278 putative trimer interface [polypeptide binding]; other site 508767009279 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 508767009280 putative CoA binding site [chemical binding]; other site 508767009281 putative trimer interface [polypeptide binding]; other site 508767009282 putative active site [active] 508767009283 putative substrate binding site [chemical binding]; other site 508767009284 putative CoA binding site [chemical binding]; other site 508767009285 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 508767009286 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 508767009287 inhibitor-cofactor binding pocket; inhibition site 508767009288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508767009289 catalytic residue [active] 508767009290 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 508767009291 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 508767009292 Predicted methyltransferases [General function prediction only]; Region: COG0313 508767009293 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 508767009294 putative SAM binding site [chemical binding]; other site 508767009295 putative homodimer interface [polypeptide binding]; other site 508767009296 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 508767009297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508767009298 S-adenosylmethionine binding site [chemical binding]; other site 508767009299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 508767009300 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 508767009301 NlpC/P60 family; Region: NLPC_P60; pfam00877 508767009302 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 508767009303 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 508767009304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508767009305 motif II; other site 508767009306 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 508767009307 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 508767009308 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 508767009309 ligand binding site [chemical binding]; other site 508767009310 active site 508767009311 UGI interface [polypeptide binding]; other site 508767009312 catalytic site [active] 508767009313 Protein of unknown function (DUF3785); Region: DUF3785; pfam12653 508767009314 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 508767009315 MPT binding site; other site 508767009316 trimer interface [polypeptide binding]; other site 508767009317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 508767009318 Predicted transcriptional regulator [Transcription]; Region: COG2378 508767009319 HTH domain; Region: HTH_11; pfam08279 508767009320 WYL domain; Region: WYL; pfam13280 508767009321 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 508767009322 putative active site [active] 508767009323 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508767009324 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 508767009325 NAD-dependent deacetylase; Provisional; Region: PRK00481 508767009326 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 508767009327 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 508767009328 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 508767009329 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 508767009330 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 508767009331 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 508767009332 E3 interaction surface; other site 508767009333 lipoyl attachment site [posttranslational modification]; other site 508767009334 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 508767009335 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 508767009336 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508767009337 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 508767009338 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 508767009339 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508767009340 MarR family; Region: MarR_2; pfam12802 508767009341 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 508767009342 CAAX protease self-immunity; Region: Abi; pfam02517 508767009343 Competence-damaged protein; Region: CinA; pfam02464 508767009344 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 508767009345 catalytic core [active] 508767009346 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 508767009347 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 508767009348 nucleotide binding site [chemical binding]; other site 508767009349 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 508767009350 elongation factor G; Reviewed; Region: PRK12740 508767009351 G1 box; other site 508767009352 putative GEF interaction site [polypeptide binding]; other site 508767009353 GTP/Mg2+ binding site [chemical binding]; other site 508767009354 Switch I region; other site 508767009355 G2 box; other site 508767009356 G3 box; other site 508767009357 Switch II region; other site 508767009358 G4 box; other site 508767009359 G5 box; other site 508767009360 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 508767009361 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 508767009362 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 508767009363 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 508767009364 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 508767009365 Sulfatase; Region: Sulfatase; pfam00884 508767009366 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 508767009367 Sulfatase; Region: Sulfatase; pfam00884 508767009368 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 508767009369 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 508767009370 Predicted integral membrane protein [Function unknown]; Region: COG5652 508767009371 FMN-binding domain; Region: FMN_bind; cl01081 508767009372 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 508767009373 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 508767009374 ligand binding site; other site 508767009375 oligomer interface; other site 508767009376 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 508767009377 dimer interface [polypeptide binding]; other site 508767009378 N-terminal domain interface [polypeptide binding]; other site 508767009379 sulfate 1 binding site; other site 508767009380 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 508767009381 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 508767009382 ligand binding site; other site 508767009383 oligomer interface; other site 508767009384 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 508767009385 dimer interface [polypeptide binding]; other site 508767009386 N-terminal domain interface [polypeptide binding]; other site 508767009387 sulfate 1 binding site; other site 508767009388 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 508767009389 homodimer interface [polypeptide binding]; other site 508767009390 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 508767009391 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 508767009392 active site 508767009393 homodimer interface [polypeptide binding]; other site 508767009394 catalytic site [active] 508767009395 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 508767009396 homodimer interface [polypeptide binding]; other site 508767009397 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 508767009398 active site pocket [active] 508767009399 glycogen synthase; Provisional; Region: glgA; PRK00654 508767009400 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 508767009401 ADP-binding pocket [chemical binding]; other site 508767009402 homodimer interface [polypeptide binding]; other site 508767009403 glycogen branching enzyme; Provisional; Region: PRK12313 508767009404 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 508767009405 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 508767009406 active site 508767009407 catalytic site [active] 508767009408 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 508767009409 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 508767009410 HPr interaction site; other site 508767009411 glycerol kinase (GK) interaction site [polypeptide binding]; other site 508767009412 active site 508767009413 phosphorylation site [posttranslational modification] 508767009414 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 508767009415 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 508767009416 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508767009417 active site turn [active] 508767009418 phosphorylation site [posttranslational modification] 508767009419 CAT RNA binding domain; Region: CAT_RBD; smart01061 508767009420 transcriptional antiterminator BglG; Provisional; Region: PRK09772 508767009421 PRD domain; Region: PRD; pfam00874 508767009422 PRD domain; Region: PRD; pfam00874 508767009423 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 508767009424 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 508767009425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 508767009426 flagellin; Reviewed; Region: PRK08869 508767009427 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 508767009428 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 508767009429 Global regulator protein family; Region: CsrA; pfam02599 508767009430 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 508767009431 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 508767009432 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 508767009433 putative ATP binding site [chemical binding]; other site 508767009434 putative substrate interface [chemical binding]; other site 508767009435 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 508767009436 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767009437 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767009438 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508767009439 YibE/F-like protein; Region: YibE_F; pfam07907 508767009440 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 508767009441 PHP domain; Region: PHP; pfam02811 508767009442 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 508767009443 generic binding surface II; other site 508767009444 generic binding surface I; other site 508767009445 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767009446 RecX family; Region: RecX; cl00936 508767009447 Predicted integral membrane protein [Function unknown]; Region: COG5652 508767009448 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508767009449 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 508767009450 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 508767009451 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 508767009452 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 508767009453 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 508767009454 active site 508767009455 tetramer interface; other site 508767009456 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 508767009457 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 508767009458 NAD binding site [chemical binding]; other site 508767009459 substrate binding site [chemical binding]; other site 508767009460 homodimer interface [polypeptide binding]; other site 508767009461 active site 508767009462 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 508767009463 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 508767009464 NADP binding site [chemical binding]; other site 508767009465 active site 508767009466 putative substrate binding site [chemical binding]; other site 508767009467 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 508767009468 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 508767009469 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 508767009470 substrate binding site; other site 508767009471 tetramer interface; other site 508767009472 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 508767009473 classical (c) SDRs; Region: SDR_c; cd05233 508767009474 NAD(P) binding site [chemical binding]; other site 508767009475 active site 508767009476 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 508767009477 active site 508767009478 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 508767009479 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 508767009480 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 508767009481 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 508767009482 active site 508767009483 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 508767009484 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 508767009485 active site 508767009486 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 508767009487 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 508767009488 trimer interface [polypeptide binding]; other site 508767009489 active site 508767009490 substrate binding site [chemical binding]; other site 508767009491 CoA binding site [chemical binding]; other site 508767009492 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 508767009493 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 508767009494 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 508767009495 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 508767009496 Substrate binding site; other site 508767009497 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 508767009498 Bacterial sugar transferase; Region: Bac_transf; pfam02397 508767009499 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 508767009500 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 508767009501 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 508767009502 Nucleotide binding site [chemical binding]; other site 508767009503 DTAP/Switch II; other site 508767009504 Chain length determinant protein; Region: Wzz; cl15801 508767009505 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 508767009506 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 508767009507 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 508767009508 Domain of unknown function DUF21; Region: DUF21; pfam01595 508767009509 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 508767009510 Transporter associated domain; Region: CorC_HlyC; pfam03471 508767009511 Uncharacterized conserved protein [Function unknown]; Region: COG4198 508767009512 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 508767009513 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 508767009514 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 508767009515 putative ligand binding site [chemical binding]; other site 508767009516 NAD binding site [chemical binding]; other site 508767009517 dimerization interface [polypeptide binding]; other site 508767009518 catalytic site [active] 508767009519 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 508767009520 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508767009521 catalytic residue [active] 508767009522 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 508767009523 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 508767009524 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 508767009525 Walker A/P-loop; other site 508767009526 ATP binding site [chemical binding]; other site 508767009527 Q-loop/lid; other site 508767009528 ABC transporter signature motif; other site 508767009529 Walker B; other site 508767009530 D-loop; other site 508767009531 H-loop/switch region; other site 508767009532 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 508767009533 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 508767009534 recombination protein RecR; Reviewed; Region: recR; PRK00076 508767009535 RecR protein; Region: RecR; pfam02132 508767009536 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 508767009537 putative active site [active] 508767009538 putative metal-binding site [ion binding]; other site 508767009539 tetramer interface [polypeptide binding]; other site 508767009540 hypothetical protein; Validated; Region: PRK00153 508767009541 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 508767009542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767009543 Walker A motif; other site 508767009544 ATP binding site [chemical binding]; other site 508767009545 Walker B motif; other site 508767009546 DNA polymerase III subunit delta'; Validated; Region: PRK08485 508767009547 arginine finger; other site 508767009548 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 508767009549 thymidylate synthase; Reviewed; Region: thyA; PRK01827 508767009550 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 508767009551 dimerization interface [polypeptide binding]; other site 508767009552 active site 508767009553 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 508767009554 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 508767009555 folate binding site [chemical binding]; other site 508767009556 NADP+ binding site [chemical binding]; other site 508767009557 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 508767009558 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 508767009559 active site 508767009560 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 508767009561 nucleoside/Zn binding site; other site 508767009562 dimer interface [polypeptide binding]; other site 508767009563 catalytic motif [active] 508767009564 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 508767009565 Domain of unknown function DUF21; Region: DUF21; pfam01595 508767009566 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 508767009567 Transporter associated domain; Region: CorC_HlyC; smart01091 508767009568 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 508767009569 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 508767009570 putative substrate binding site [chemical binding]; other site 508767009571 putative ATP binding site [chemical binding]; other site 508767009572 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 508767009573 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 508767009574 substrate binding [chemical binding]; other site 508767009575 active site 508767009576 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 508767009577 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508767009578 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508767009579 DNA binding site [nucleotide binding] 508767009580 domain linker motif; other site 508767009581 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 508767009582 dimerization interface [polypeptide binding]; other site 508767009583 ligand binding site [chemical binding]; other site 508767009584 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 508767009585 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508767009586 active site turn [active] 508767009587 phosphorylation site [posttranslational modification] 508767009588 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 508767009589 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 508767009590 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 508767009591 phosphate binding site [ion binding]; other site 508767009592 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 508767009593 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508767009594 putative active site [active] 508767009595 metal binding site [ion binding]; metal-binding site 508767009596 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722 508767009597 phosphate binding site [ion binding]; other site 508767009598 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 508767009599 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 508767009600 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 508767009601 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 508767009602 substrate binding site [chemical binding]; other site 508767009603 ATP binding site [chemical binding]; other site 508767009604 Isochorismatase family; Region: Isochorismatase; pfam00857 508767009605 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 508767009606 catalytic triad [active] 508767009607 conserved cis-peptide bond; other site 508767009608 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 508767009609 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 508767009610 TM-ABC transporter signature motif; other site 508767009611 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 508767009612 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 508767009613 TM-ABC transporter signature motif; other site 508767009614 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 508767009615 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 508767009616 Walker A/P-loop; other site 508767009617 ATP binding site [chemical binding]; other site 508767009618 Q-loop/lid; other site 508767009619 ABC transporter signature motif; other site 508767009620 Walker B; other site 508767009621 D-loop; other site 508767009622 H-loop/switch region; other site 508767009623 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 508767009624 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 508767009625 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 508767009626 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 508767009627 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508767009628 DNA-binding site [nucleotide binding]; DNA binding site 508767009629 UTRA domain; Region: UTRA; pfam07702 508767009630 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 508767009631 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508767009632 DNA-binding site [nucleotide binding]; DNA binding site 508767009633 UTRA domain; Region: UTRA; pfam07702 508767009634 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 508767009635 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508767009636 Soluble P-type ATPase [General function prediction only]; Region: COG4087 508767009637 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 508767009638 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 508767009639 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 508767009640 putative acyl-acceptor binding pocket; other site 508767009641 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 508767009642 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 508767009643 ATP binding site [chemical binding]; other site 508767009644 Mg++ binding site [ion binding]; other site 508767009645 motif III; other site 508767009646 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508767009647 nucleotide binding region [chemical binding]; other site 508767009648 ATP-binding site [chemical binding]; other site 508767009649 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 508767009650 RNA binding site [nucleotide binding]; other site 508767009651 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 508767009652 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 508767009653 putative dimer interface [polypeptide binding]; other site 508767009654 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508767009655 Zn2+ binding site [ion binding]; other site 508767009656 Mg2+ binding site [ion binding]; other site 508767009657 Phosphotransferase enzyme family; Region: APH; pfam01636 508767009658 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 508767009659 active site 508767009660 substrate binding site [chemical binding]; other site 508767009661 ATP binding site [chemical binding]; other site 508767009662 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 508767009663 hypothetical protein; Provisional; Region: PRK06851 508767009664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767009665 Walker A motif; other site 508767009666 ATP binding site [chemical binding]; other site 508767009667 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 508767009668 G1 box; other site 508767009669 GTP/Mg2+ binding site [chemical binding]; other site 508767009670 G2 box; other site 508767009671 Switch I region; other site 508767009672 G3 box; other site 508767009673 Switch II region; other site 508767009674 G5 box; other site 508767009675 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 508767009676 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 508767009677 putative ligand binding residues [chemical binding]; other site 508767009678 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 508767009679 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 508767009680 Walker A/P-loop; other site 508767009681 ATP binding site [chemical binding]; other site 508767009682 Q-loop/lid; other site 508767009683 ABC transporter signature motif; other site 508767009684 Walker B; other site 508767009685 D-loop; other site 508767009686 H-loop/switch region; other site 508767009687 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 508767009688 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508767009689 ABC-ATPase subunit interface; other site 508767009690 dimer interface [polypeptide binding]; other site 508767009691 putative PBP binding regions; other site 508767009692 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 508767009693 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508767009694 ABC-ATPase subunit interface; other site 508767009695 dimer interface [polypeptide binding]; other site 508767009696 putative PBP binding regions; other site 508767009697 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508767009698 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508767009699 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 508767009700 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 508767009701 Sulfate transporter family; Region: Sulfate_transp; pfam00916 508767009702 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 508767009703 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 508767009704 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 508767009705 dimer interface [polypeptide binding]; other site 508767009706 active site 508767009707 catalytic residue [active] 508767009708 Lysine riboswitch 508767009709 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 508767009710 hypothetical protein; Provisional; Region: PRK10621 508767009711 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 508767009712 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 508767009713 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 508767009714 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 508767009715 active site 508767009716 nucleophile elbow; other site 508767009717 PEP synthetase regulatory protein; Provisional; Region: PRK05339 508767009718 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 508767009719 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 508767009720 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 508767009721 G1 box; other site 508767009722 GTP/Mg2+ binding site [chemical binding]; other site 508767009723 Switch I region; other site 508767009724 G2 box; other site 508767009725 Switch II region; other site 508767009726 G3 box; other site 508767009727 G4 box; other site 508767009728 G5 box; other site 508767009729 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 508767009730 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 508767009731 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 508767009732 ligand binding site [chemical binding]; other site 508767009733 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 508767009734 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 508767009735 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 508767009736 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 508767009737 NAD binding site [chemical binding]; other site 508767009738 dimer interface [polypeptide binding]; other site 508767009739 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508767009740 substrate binding site [chemical binding]; other site 508767009741 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508767009742 dimerization interface [polypeptide binding]; other site 508767009743 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508767009744 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508767009745 dimer interface [polypeptide binding]; other site 508767009746 putative CheW interface [polypeptide binding]; other site 508767009747 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508767009748 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 508767009749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508767009750 ATP binding site [chemical binding]; other site 508767009751 Mg2+ binding site [ion binding]; other site 508767009752 G-X-G motif; other site 508767009753 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508767009754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508767009755 active site 508767009756 phosphorylation site [posttranslational modification] 508767009757 intermolecular recognition site; other site 508767009758 dimerization interface [polypeptide binding]; other site 508767009759 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508767009760 DNA binding site [nucleotide binding] 508767009761 FtsX-like permease family; Region: FtsX; pfam02687 508767009762 FtsX-like permease family; Region: FtsX; pfam02687 508767009763 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508767009764 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 508767009765 Walker A/P-loop; other site 508767009766 ATP binding site [chemical binding]; other site 508767009767 Q-loop/lid; other site 508767009768 ABC transporter signature motif; other site 508767009769 Walker B; other site 508767009770 D-loop; other site 508767009771 H-loop/switch region; other site 508767009772 Transcriptional regulators [Transcription]; Region: MarR; COG1846 508767009773 MarR family; Region: MarR; pfam01047 508767009774 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 508767009775 catalytic residues [active] 508767009776 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 508767009777 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508767009778 Zn2+ binding site [ion binding]; other site 508767009779 Mg2+ binding site [ion binding]; other site 508767009780 TIGR03987 family protein; Region: TIGR03987 508767009781 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508767009782 MarR family; Region: MarR_2; pfam12802 508767009783 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 508767009784 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 508767009785 PYR/PP interface [polypeptide binding]; other site 508767009786 dimer interface [polypeptide binding]; other site 508767009787 TPP binding site [chemical binding]; other site 508767009788 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 508767009789 transketolase; Reviewed; Region: PRK05899 508767009790 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 508767009791 TPP-binding site [chemical binding]; other site 508767009792 dimer interface [polypeptide binding]; other site 508767009793 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 508767009794 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 508767009795 active site 508767009796 P-loop; other site 508767009797 phosphorylation site [posttranslational modification] 508767009798 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 508767009799 active site 508767009800 phosphorylation site [posttranslational modification] 508767009801 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 508767009802 HTH domain; Region: HTH_11; pfam08279 508767009803 PRD domain; Region: PRD; pfam00874 508767009804 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 508767009805 active site 508767009806 P-loop; other site 508767009807 phosphorylation site [posttranslational modification] 508767009808 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 508767009809 active site 508767009810 phosphorylation site [posttranslational modification] 508767009811 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 508767009812 catalytic residues [active] 508767009813 dimer interface [polypeptide binding]; other site 508767009814 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 508767009815 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 508767009816 Ca binding site [ion binding]; other site 508767009817 active site 508767009818 catalytic site [active] 508767009819 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 508767009820 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 508767009821 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508767009822 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508767009823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508767009824 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 508767009825 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 508767009826 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 508767009827 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 508767009828 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 508767009829 active site 508767009830 catalytic site [active] 508767009831 metal binding site [ion binding]; metal-binding site 508767009832 Flavodoxin domain; Region: Flavodoxin_3; pfam12641 508767009833 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 508767009834 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 508767009835 active site 508767009836 FMN binding site [chemical binding]; other site 508767009837 substrate binding site [chemical binding]; other site 508767009838 Transcriptional regulators [Transcription]; Region: MarR; COG1846 508767009839 MarR family; Region: MarR_2; pfam12802 508767009840 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 508767009841 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 508767009842 ATP binding site [chemical binding]; other site 508767009843 Mg++ binding site [ion binding]; other site 508767009844 motif III; other site 508767009845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508767009846 nucleotide binding region [chemical binding]; other site 508767009847 ATP-binding site [chemical binding]; other site 508767009848 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508767009849 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 508767009850 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 508767009851 hypothetical protein; Provisional; Region: PRK05590 508767009852 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 508767009853 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 508767009854 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 508767009855 hinge; other site 508767009856 active site 508767009857 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 508767009858 metal binding site [ion binding]; metal-binding site 508767009859 Protein of unknown function, DUF606; Region: DUF606; pfam04657 508767009860 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 508767009861 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 508767009862 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 508767009863 active site 508767009864 catalytic residues [active] 508767009865 G5 domain; Region: G5; pfam07501 508767009866 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 508767009867 Peptidase family M23; Region: Peptidase_M23; pfam01551 508767009868 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 508767009869 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 508767009870 DNA replication protein DnaC; Validated; Region: PRK06835 508767009871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 508767009872 Walker A motif; other site 508767009873 ATP binding site [chemical binding]; other site 508767009874 flavoprotein, HI0933 family; Region: TIGR00275 508767009875 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508767009876 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 508767009877 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 508767009878 active site 508767009879 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 508767009880 active site 2 [active] 508767009881 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 508767009882 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 508767009883 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 508767009884 GDP-binding site [chemical binding]; other site 508767009885 ACT binding site; other site 508767009886 IMP binding site; other site 508767009887 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 508767009888 Malic enzyme, N-terminal domain; Region: malic; pfam00390 508767009889 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 508767009890 putative NAD(P) binding site [chemical binding]; other site 508767009891 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 508767009892 pyrroline-5-carboxylate reductase; Region: PLN02688 508767009893 replicative DNA helicase; Provisional; Region: PRK05595 508767009894 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 508767009895 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 508767009896 Walker A motif; other site 508767009897 ATP binding site [chemical binding]; other site 508767009898 Walker B motif; other site 508767009899 DNA binding loops [nucleotide binding] 508767009900 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 508767009901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508767009902 Walker A motif; other site 508767009903 ATP binding site [chemical binding]; other site 508767009904 Walker B motif; other site 508767009905 arginine finger; other site 508767009906 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 508767009907 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 508767009908 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 508767009909 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 508767009910 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 508767009911 DHH family; Region: DHH; pfam01368 508767009912 DHHA1 domain; Region: DHHA1; pfam02272 508767009913 MazG-like family; Region: MazG-like; pfam12643 508767009914 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 508767009915 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 508767009916 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 508767009917 dimer interface [polypeptide binding]; other site 508767009918 ssDNA binding site [nucleotide binding]; other site 508767009919 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508767009920 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 508767009921 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 508767009922 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 508767009923 Mechanosensitive ion channel; Region: MS_channel; pfam00924 508767009924 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 508767009925 LysE type translocator; Region: LysE; cl00565 508767009926 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 508767009927 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 508767009928 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508767009929 catalytic residue [active] 508767009930 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 508767009931 ParB-like nuclease domain; Region: ParBc; pfam02195 508767009932 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 508767009933 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 508767009934 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 508767009935 P-loop; other site 508767009936 Magnesium ion binding site [ion binding]; other site 508767009937 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 508767009938 Magnesium ion binding site [ion binding]; other site 508767009939 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 508767009940 ParB-like nuclease domain; Region: ParB; smart00470 508767009941 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 508767009942 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 508767009943 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 508767009944 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508767009945 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 508767009946 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 508767009947 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 508767009948 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 508767009949 trmE is a tRNA modification GTPase; Region: trmE; cd04164 508767009950 G1 box; other site 508767009951 GTP/Mg2+ binding site [chemical binding]; other site 508767009952 Switch I region; other site 508767009953 G2 box; other site 508767009954 Switch II region; other site 508767009955 G3 box; other site 508767009956 G4 box; other site 508767009957 G5 box; other site 508767009958 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 508767009959 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 508767009960 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 508767009961 G-X-X-G motif; other site 508767009962 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 508767009963 RxxxH motif; other site 508767009964 putative inner membrane protein translocase component YidC; Provisional; Region: PRK00145 508767009965 ribonuclease P; Reviewed; Region: rnpA; PRK00499 508767009966 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399